Articles de revues sur le sujet « Secoli 17/18 »

Self-medication is the use of drugs to treat self-diagnosed diseases or symptoms. The purpose of the following work was to determine self-medication in nursing students of the Universidad Católica de Cuenca - Azogues during the period 2020 - 2021. A non-experimental design, descriptive-correlational and prospective cross-sectional study was conducted, with a quantitative approach, with a sample of 168 students who were studying during the academic period: October 2020 - February 2021. The most prevalent sex was female (89.5%); the mean age was 21.65 years, the percentage of self-medication in the last year was (78.6%); the most used drugs were (NSAIDs) with (47.7%). Among the factors found were: source of information: own knowledge, consultation with friends and family, internet; according to the place where it is acquired: pharmacy. Conclusion: the practice of self-medication is high in the university population. Keywords: practice, self-medication, university students. 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Field studies were conducted in 2016 and 2017 in Tallassee, AL, to evaluate the effect of preemergence (PRE) herbicide applications pre- and postcrimp in a cereal rye (Secale cereale) cover crop for control of escape weeds in watermelon (Citrullus lanatus). Treatments were arranged in a randomized complete block design with an augmented factorial treatment arrangement with four replications. The augmented factorial arrangement included three levels of PRE herbicides, two levels of application timing, and a nontreated control. PRE herbicide treatments included ethalfluralin (18 oz/acre), fomesafen (2.5 oz/acre), and halosulfuron (0.56 oz/acre). Application timings were precrimp (herbicide applied before crimping and rolling of the cover crop) and postcrimp (herbicide applied after crimping and rolling of the cover crop). A nontreated cover crop only treatment was also included. There were no interactions among application timing and herbicide. Results indicated application timing influenced total weed coverage but not watermelon yield. Total weed coverage was lowest in precrimp applied treatments at 2, 4, and 6 weeks after treatment (WAT). Comparing individual treatments revealed no significant differences among herbicides with respect to watermelon yield; however, all herbicides increased yield compared with the nontreated.

Introductions: The termination of second trimester pregnancy is challenging due unfavorable cervix. This study evaluate the efficacy and maternal side effects of intravaginal misoprostol for termination of second trimester pregnancy. Methods: During one year period from 15th June 2011 to 14th June 2012, Department of Obstetrics and Gynaecology of Patan Hospital, women admitted for second trimester termination of pregnancy for fetal congenital anomalies and intrauterine fetal demise were studied using the International Federation of Gynaecology and Obstetrics recommended doses of vaginal misoprostol. For congenital anomalies, 400 mcg 3 hourly to a maximum of 5 doses were used. For fetal demise, gestational age of 13-17 weeks received 200 mcg every 6 hourly to a maximum of 4 doses, and 18-26 weeks dose was adjusted to 100 mcg. Main outcome measures included success rate of abortion within 48 hours, induction to delivery interval and maternal side effects. Results: There were 40 patients during study period. Success rate for termination of 2nd trimester pregnancy within 48 hours was 88.8% for congenital anomalies. For fetal demise, success of termination was 90.9% at 13-17 weeks and 100% at 18-26 weeks. Median time from induction to delivery was 26.8 hours for congenital anomalies. For fetal demise, it was 18 hours for 13-17 weeks was and 24 hours at 18 to 26 weeks respectively. Abdominal pain was seen in all doses of misoprostol. Conclusions: Vaginal misoprostol is an effective method for termination of second trimester pregnancy. Plain Language Summary: The study was conducted to see the effectiveness of vaginal misoprostol for termination of second trimester pregnancy. The success rate of termination for congenital abnormality and fetal demise was high. Vaginal misoprostol was an effective method for termination of second trimester pregnancy. DOI: http://dx.doi.org/10.3126/jpahs.v1i1.13010 Journal of Patan Academy of Health Sciences. 2014 Jun;1(1):16-19

Abstract Purpose To explore the efficacy and safety of using radiofrequency ablation (RFA) combined with transarterial chemoembolization (TACE) for treating hepatocellular carcinoma (HCC) adjacent to the second hepatic hilus. Methods Between February 2011 and June 2013, 17 patients with HCC underwent combination therapy of TACE and RFA under DSA and CT guidance at our institution. The 17 patients had a total of 23 hepatic tumors, 17 of which were adjacent to the second hepatic hilus. Results TACE combined with RFA was performed successfully in all 17 patients with no mortalities or major morbidities. During the 1-month follow-up, tumors of 15 patients (88.2%) were completely ablated after one therapy session and 2 patients had detectable tumor residue. During the follow-up time period (range 6–52 months), local tumor progression developed in 1 patient (1/17, 5.9%) and both local tumor progression and new tumors appeared in 1 patient (1/17, 5.9%). Also, new tumors developed in the untreated portions of the liver in 8 patients (8/17, 47.1%). No distant metastasis was found. Of the 17 patients, 6 (35.3%) died due to tumor progression (3/17, 17.6%), liver failure (2/17, 11.8%), or massive hemorrhage of the gastrointestinal tract (1/17, 5.9%). The overall survival rates were 94.1% (16/17), 82.4% (14/17), and 61.8% (11/17) at 12, 18, and 24 months, respectively, and the median survival time was 25 months (95% CI 18–27). Conclusion Treatment using combination of TACE and RFA is an effective and safe therapeutic strategy for treating HCC with tumor(s) adjacent to the second hepatic hilus.

The second sentence of line 18 (= line 1 on the east side of the first stele) of the Tunyukuk Inscription has been amended as [: eki] süm[üz b]oltï or [biz eki sü b]oltï ‘We had two armies’. Considering the second sentence of line 17, the information from the first and second sentences of line 18 would be that the peoples around us joined us and thus the number of our soldiers, which was 2,000, increased. If that is the case, the second sentence may be hypothetically amended as [: bir] tüm[än b]oltï ‘It (= the number of our soldiers) became 10,000’ or [: eki] tüm[än b]oltï ‘It (= the number of our soldiers) became 20,000’.

Настоящая работа является первым общим описанием на русском языке двух некрополей Кампокиаро (Кампобассо, Италия) – Виченне и Морионе, датируемых последней третью VII в. – началом VIII в. Культурное содержание некрополей показывает прочные связи с населением центральноазиатского происхождения. Важнейшим признаком некрополей являются захоронения с конем, соответствующие евразийскому кочевому погребальному обряду. Автор поддержал выводы европейских исследователей о том, что с большой долей вероятности некрополи оставлены булгарами дукса–гаштальда Алзеко, зафиксированными Павлом Диаконом в VIII в. на территориях Бояно, Сепино и Изернии. Аналогии некрополей Кампокиаро с погребениями Аварского каганата показывают присутствие в аварском обществе булгар со схожим погребальным обрядом. Из тысяч погребений с конем, оставленных аварским населением, булгарам могла принадлежать большая часть. Авары и булгары составляли основу и правящую верхушку каганата. 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Spatial and temporal variability and bloom formation of the potentially toxic diatom Pseudo-nitzschia spp. was investigated weekly to monthly from October 2009 to October 2010 in a eutrophic estuary, the Golden Horn. Pseudo-nitzschia spp. were detected in 195 of 512 samples (38%) collected throughout the year. Two species, P. calliantha and P. pungens, were identified based on the SEM examination. Blooms of Pseudo-nitzschia occurred in the lower and middle estuary in January and May. The bloom in January mainly comprised P. calliantha. In the bloom in early May, P. calliantha made up 72% of the Pseudo-nitzschia cells and P. pungens 28%. However, the contribution of P. pungens increased to 83% in late May. The Pseudo-nitzschia blooms occurred at low temperature (9–15°C) and moderate salinity (17–18), and for P. calliantha a significant negative correlation was found with temperature and a significant positive correlation with salinity. The percentage of Pseudo-nitzschia cells decreased gradually from lower to upper estuary (59–14%), correlating with a decrease in Secchi depth (5.5–0.5 m). Principal components analyses (PCA) were used to explore the spatial and temporal variability of environmental factors in relation to Pseudo-nitzschia abundances, and showed that NH4, pH, Secchi depth and DO values were the most important factors reflecting spatial differences, while temperature, salinity, Chl-a and Si:N were more important factors showing temporal differences. High abundances of P. pungens correlated mainly with pH, Secchi depth and DO values, whereas P. calliantha also correlated with NO3 + NO2. Low light availability due to high concentrations of suspended material and very variable environmental conditions (e.g. pH, DO and NH4) may have limited growth of Pseudo-nitzschia in the upper estuary. Regular monitoring of Pseudo-nitzschia is important for improving the understanding of the influence of environmental parameters on bloom dynamics in the study area.

Two new acentric isoxazolone-based organic crystals of C₂₄H₁₇NO₃ (MPFI) and C₁₈H₁₅NO₃S (MPMI) were designed and synthesized by a structure fine-tuning strategy.

A new species of the uranoscopid genus Kathetostoma Günther, 1860, is described from New Zealand waters, where it is broadly sympatric with its sole local congener K. giganteum Haast, 1873. The new species is readily recognised by its broad, saddle-like dark bands that cross the body dorsally (versus bands absent or only faintly developed), rather robust and short body (vs slender and elongate), and fewer numbers of vertebrae (30–31 versus 33–34), dorsal fin rays (15–17 versus 17–19) and anal fin rays (15–16 versus 17–18). Although both species have extremely broad depth distributions, the new species appears to be restricted to less than about 500 m, with its greatest abundance at 100–300 m, while K. giganteum reaches over 1000 m, and has its greatest abundance at 200–400 m. A brief redescription of K giganteum is also provided. Kathetostoma fluviatilis Hutton, 1972, the oldest New Zealand name that applies to this genus, is regarded as a nomen dubium.

On 1983 May 10–11 we undertook simultaneous λ3.6 and λ13 cm Mark III VLBI observations of the quasars 1038+528 A,B. Our experimental conditions (i.e., synthesized band, uv-coverage, etc.) were almost identical to those we used on 1981 March 17–18. Thus, we could make a direct comparison of the results from both epochs.

Since the work of Sanders, the question of participation has been at the center of Pauline soteriological debates. In this article, we argue that the salvation-historical and apocalyptic aspects of Paul's thought can be integrated by means of what might be called “cultic theosis.” We begin by looking at the way the cult figured prominently in Jewish eschatological hopes (e.g., Isa 2:2–3; 56:3–7; Ezek 40–48; Mal 3:1–3). We also show that in certain texts it was linked to participation in divine realities or what could broadly be described as “theosis” (e.g., Sir 50:1–22; Philo, Somn. 2.188–89; 2.231–32; 4Q511 XXXV, 3–5; 1QHᵃ XI, 21–22; 4Q400 II, 1). It is against this background that we investigate Paul's cultic language in 1 Corinthians. Not only does Paul view the church as the eschatological temple (1 Cor 3:16–17; 6:19), according to him it is through the ongoing cultic life of the church that believers participate in the body of “the man from heaven” (1 Cor 10:16–17; 15:47–49) and enter into the presence of heavenly realities (1 Cor 11:10). Moreover, our survey of Jewish texts illuminates Paul's account of the Lord's Supper (1 Cor 11:23–26), which itself evokes cultic imagery (e.g., Exod 24:3–11). Specifically, it explains the way Paul describes participation (κοινωνία) in Christ through the eucharist (1 Cor 10:16–17) in terms of Israel's sacrificial worship, through which the people become “sharers” (κοινωνοί) in the altar (1 Cor 10:18).

Since the work of Sanders, the question of participation has been at the center of Pauline soteriological debates. In this article, we argue that the salvation-historical and apocalyptic aspects of Paul's thought can be integrated by means of what might be called “cultic theosis.” We begin by looking at the way the cult figured prominently in Jewish eschatological hopes (e.g., Isa 2:2–3; 56:3–7; Ezek 40–48; Mal 3:1–3). We also show that in certain texts it was linked to participation in divine realities or what could broadly be described as “theosis” (e.g., Sir 50:1–22; Philo, Somn. 2.188–89; 2.231–32; 4Q511 XXXV, 3–5; 1QHᵃ XI, 21–22; 4Q400 II, 1). It is against this background that we investigate Paul's cultic language in 1 Corinthians. Not only does Paul view the church as the eschatological temple (1 Cor 3:16–17; 6:19), according to him it is through the ongoing cultic life of the church that believers participate in the body of “the man from heaven” (1 Cor 10:16–17; 15:47–49) and enter into the presence of heavenly realities (1 Cor 11:10). Moreover, our survey of Jewish texts illuminates Paul's account of the Lord's Supper (1 Cor 11:23–26), which itself evokes cultic imagery (e.g., Exod 24:3–11). Specifically, it explains the way Paul describes participation (κοινωνία) in Christ through the eucharist (1 Cor 10:16–17) in terms of Israel's sacrificial worship, through which the people become “sharers” (κοινωνοί) in the altar (1 Cor 10:18).

Abstract Background: Newborn screening for congenital adrenal hyperplasia (CAH) involves measurement of 17α-hydroxyprogesterone (17-OHP), usually by immunoassay. Because this testing has been characterized by high false-positive rates, we developed a steroid profiling method that uses liquid chromatography–tandem mass spectrometry (LC-MS/MS) to measure 17-OHP, androstenedione, and cortisol simultaneously in blood spots. Methods: Whole blood was eluted from a 4.8-mm (3/16-inch) dried-blood spot by an aqueous solution containing the deuterium-labeled internal standard d8-17-OHP. 17-OHP, androstenedione, and cortisol were extracted into diethyl ether, which was subsequently evaporated and the residue dissolved in LC mobile phase. This extract was injected into a LC-MS/MS equipped with pneumatically assisted electrospray. The steroids were quantified in the selected-reaction monitoring mode by use of peak areas in reference to the stable-isotope-labeled internal standard. We analyzed 857 newborn blood spots, including 14 blood spots of confirmed CAH cases and 101 of false-positive cases by conventional screening. Results: Intra- and interassay CVs for 17-OHP were 7.2–20% and 3.9–18%, respectively, at concentrations of 2, 30, and 50 μg/L. At a cutoff for 17-OHP of 12.5 μg/L and a cutoff of 3.75 for the sum of peak areas for 17-OHP and androstenedione divided by the peak area for cortisol, 86 of the 101 false-positive samples were within reference values by LC-MS/MS, whereas the 742 normal and 14 true-positive results obtained by conventional screening were correctly classified. Conclusion: Steroid profiling in blood spots can identify false-positive results obtained by conventional newborn screening for CAH.

Abstract Naturally infested early-blister-stage field corn was treated 22 Jul. Three insecticides and one untreated control were replicated 4 times. All plots consisted of 4 contiguous rows, each 12 m long with 76-cm row spacing. Sprays were applied in water (20 gal/acre) with a CO2-powered system held above the canopy on a modified backpack frame. Each treated row received spray applied at 40 psi from 1 nozzle suspended over the row, perpendicular to the row (tip size HC-6). The growing season was characterized by severe drought and extreme temperatures. No rain fell for 18 d after the plots were treated. Twenty plants from the 2 center rows were destroyed and examined 16-17 Aug. Tunnels/20 plants and larvae/20 plants were recorded for each plot.

The purpose of the article is to analyze the influence of the «female factor» in the family of General Judge Vasyl Kochubey (about 1640–1708), to trace the role of women in supporting the socio-political activity of this family in the elite environment of the Hetmanate. Based on historical sources, contemporary reports and historical intelligence, the author paints a portrait of his wife Lyubov Kochubey and daughters. The methodology of the research his based on a combination of general scientific (analysis, synthesis, generalization) and special-historical methods (historical-structural, historical-anthropological, historical-comparative, prosopographic) with the principles of historicism and objectivity. The application of these methods made it possible to conduct a systematic analysis of the sources, which in their interconnection helped to characterize the activities of the "female" component of the Kochubey family, to analyze the relationships between family members and their environment. Scientific novelty of the work is that for the first time a comprehensive analysis of the situation of women from the family of V. Kochubey has been made, their role in the socio-political and economic sphere was determined. The history of the acquisition and return of Kochubei land holdings during the second half of the 17th–18th centuries is traced from new positions. Conclusions. Research and reproduction of the biography of the Cossack-officer family Kochubey, showed that its representatives were part of the elite stratum of society of the Hetmanate. Successful marital contacts led to the enrichment of the family, the formation of its property potential, provided political and economic support. The members of the family became related to Zhuchenko, Skoropadsky, Obidovsky, Mazepa, Chuykevych, Apostol, Sulima, Zabila, through whose ties vital issues were resolved. During the investigation initiated after V. Kochubey’s denunciation of Hetman I. Mazepa, his wife L. Kochubey supported the family, defending her rights and interests using family ties. It is observed that the «female factor» played a major role in the return of land holdings, which were selected by order of Russian Tsar Peter I.

Abstract Purpose: To compare efficacy and safety of BDbortezomib and dexamethasone in multiple myeloma as first-line, second-line or third-line treatment. Patients and methods: 18 patients(pts) treated with BD (bortezomig 1.3mg/m2 on d 1,4,8,11 and dexamethasone 20mg on d 1–4 in a 21-day cycle). Responses were evaluated by the criteria of EBMT but a nCR was included. Adverse events were graded by the WHO criteria. Results: The median age was 52.5 years, and 13 (72.2%) were male. Ig subtypes were IgG, (8 pts, 44.4%), IgA (4 pts, 22.2%), light chain (2 pts, 11.1%), and IgD (1 pts, 5.9%). Durine/Salmon staging: IIA 5.9% (1/18), IIB 5.9% (1/18), IIIA 72.2% (13/18), IIIB16.6% (3/18). BD was administered in first-line (4 pts, 22.2%), second-line (7 pts 38.9%) and third-line (7 pts, 38.9%). The median number of BD cycles was 2.5 (range, 1–6 cycles). 17 pts could be evaluated, overall response was 88.3%, including CR in 2 pts (11.7%), nCR in 5 pts (29.4%), PR in 7 pts (41.2%), MR in 1 pts(5.9%), NC in 1 pts(5.9%), PD in 1 pts(5.9%). Pts in the first-line group received a response of 100%(4/4), including nCR in 1 pts (25.0%), PR in 2 pts (50.0%), MR in 1 pts(25.0%). The second-line group received a response of 100%(7/7), including CR in 1 pts(14.3%), nCR in 3 pts (42.9%), PR in 3 pts (42.9%). Those received BD as third-line or more got a response of 66.7% (4/6), including CR in 1 pts(16.7%), nCR in 1 pts (16.7%), PR in 2 pts (33.3%). Aderse events included diarrhea 44.4% (8/18; grade IV: 2/18), thrombocytopenia 44.4% (8/18; grade III–IV: 7/18), fatigue 44.4% (8/18; grade IV: 1/18), peripheral neuropathy 33.3% (6/18, grade II:1/18), pyrexia 22.2%, infection 16.7% (3/18), headache 11.1%(2/18), parageusis 11.1%(2/18), hypotension 5.9%(1/18), hypoglycemia 5.9%(1/18) while combining with glipizide. The median time to minimum counts of platets was 14 days. The median time to most serious peripheral neuropathy appeared after treatment of 3 cycles. In 1 pts the therapy was disrupted by toxicity. Conclusion: BD demonstrated better response as first-line or second-line therapy than as third or more line therapy. Toxicities were torelated and manegable. There were no treatment related deaths.

In its judgment issued on 17 January 2005, in Prosecutor v. Vidoje Blagojević and Dragan Jokić, Trial Chamber I, Section A, found that genocide had been committed against the Bosnian Muslim population following the fall of the Srebrenica ‘safe area’ in July 1995. The Trial Chamber's findings that forcible transfer, when combined with other acts, can constitute an underlying act of genocide (namely, causing serious mental harm to members of a group) contributes to a growing body of jurisprudence on genocide. The Trial Chamber found the accused guilty of such serious crimes as complicity in genocide, extermination, persecutions and murder. It determined that the appropriate mode of liability for each was aiding and abetting rather than committing through participation in a joint criminal enterprise, Accordingly the Trial Chamber sentenced Vidoje Blagojević to 18 years' imprisonment and Dragan Jokić to nine years' imprisonment.

Objective: To evaluate the ability of second-trimester placental volume and vascular indices to predict small-for-gestational-age (SGA) birth weight pregnancies. Material and Methods: Women with singleton pregnancies were prospectively evaluated at 17-20 weeks of gestation. Second-trimester placental volume and vascular indices were obtained and calculated using volume organ computer-aided analysis and three-dimensional (3D) power Doppler ultrasound. Participants were followed until delivery and their medical records were reviewed, including maternal age, parity and pregestational body weight and body height, as well as the gestational age, birth weight and gender of the fetus. Results: Of the 163 women with complete follow-up, 20 gave birth to SGA and 143 to appropriate-for-gestational-age (AGA) neonates. The mean second-trimester placental volume was significantly lower in the SGA than in the AGA group (170.6 ± 49.8 vs. 213.5 ± 75.8 cm3, p = 0.015). None of the vascular indices, including the vascularization index, flow index and vascularization flow index, differed significantly between the two groups. We also found that the optimum cutoff for placental volume at a gestational age of 17-18 weeks was 189.7 cm3. Discussion: Second-trimester placental volume was positively correlated with neonatal birth weight. Second-trimester placental volume measured on 3D ultrasound may be predictive of SGA neonates.

Presented at the Second Language Research Forum, Michigan State University, USA; 30 October 2009Recent years have brought increasing attention to studies of language acquisition in a country where the language is spoken, as opposed to formal language study in classrooms. Research on language learners in immersion contexts is important, as the question of whether study abroad is valuable is still somewhat controversial among researchers (DeKeyser 2007; Sunderman & Kroll 2009). In the introduction to a pioneering volume on language study abroad, Freed (1995, pp. 17–18) noted that a vital question concerns the relative linguistic benefits of a summer, a semester or a year in the foreign environment. Our purpose in this colloquium, which was organized by Lynne Hansen, was to introduce a new line of research which allows comparisons of L2 attainment over these exposure times as well as longer periods. Tens of thousands of young missionaries for the Church of Jesus Christ of Latter-day Saints (also known as the LDS or Mormon Church), advanced speakers of some fifty languages, return home annually after two years of language learning abroad. This natural sample of learners, in its relative uniformity of learner characteristics and learning contexts, allows for the control of variables in SLA research which can be problematic in studies of more heterogeneous groups.

The Diagnostic Value of the Second Generation Anti-CCP Test in Rheumatoid ArthritisThe purpose of this research was to compare the diagnostic values of laboratory variables, to present quantitative evaluations of the diagnostic test with reference to sensitivity, and specificity, the predictive value of the positive and negative test and precision of the test for anti-cyclic citrullinated peptide (anti-CCP 2) antibodies, rheumatoid factor (RF), C-reactive protein (CRP), DAS 28 index, in early diagnosis of untreated rheumatoid arthritis (RA). Using the ELISA technology of DIA-STAT™Anti-CCP (Axis-Shield Diagnostics), the serum has been examined in 70 participants (35 RA who were not treated, 35 healthy controls). RF was defined with the test for agglutination (Latex RF test) in the same participants. In 23 of the 35 examined patients with RA, we found presence of anti-CCP 2 antibodies (sensitivity of the test 65.71%), while RF appeared in 17 patients (sensitivity of the test 48.57%). Twelve patients were anti-CCP 2 and RF positive, 11 were anti-CCP 2 positive but RF negative. Five patients were anti-CCP 2 negative and RF positive. Out of 18 RF negative patients, 11 were anti-CCP 2 positive. In 17 RF positive patients, anti-CCP 2 antibodies were positive in 12 patients. In the healthy control group, 1 patient was anti-CCP 2 positive, while 2 patients were RF positive. Anti-CCP 2 antibodies have higher sensitivity and specificity than RF in RA.

Abstract Abstract 1300 Introduction: Around 20–30% patients (pts) with primary myelofibrosis (PMF) experience relapses within 3 years after dose-reduced conditioning followed by allogeneic stem cell transplantation (HSCT). The prognosis for those pts is unclear, and standard treatment recommendations have not yet been proposed. Early withdrawal of post-transplant immunosuppression, use of dose escalating donor lymphocyte infusions (DLIs), and/or 2nd HSCT have been suggested as therapeutic options for pts relapsing after HSCT. Although DLIs were found to be effective in certain disease as salvage approach, the role of 2nd HSCT for non-responding patients remains controversial. Here we report on our multicenter experience on the use of a two-stage salvage strategy including DLIs and a 2nd RIC-HSCT in pts with post-transplant relapse of PMF. It was planned to start salvage therapy with DLI and only non-responding patients as well as patients with transformation to blast crisis and complete loss of donor chimerisms were assigned to receive a second allogeneic stem cell transplantation. Responses were evaluated using the International Working Group consensus criteria for treatment response in myelofibrosis. Additionally, the JAK2V617F mutation level (in 1 case, the MPLW515mut level) and donor chimerism were used to assess the molecular remission status. Patients/Methods: Thirty pts with morphologic (n=24) or molecular (n=6) relapse of PMF after 1st HSCT were proceeded to a salvage strategy, including DLIs and/or 2nd RIC-HSCT. Median time from transplantation to relapse was 9 months (range, 2–62). 26 pts received a median of 3 (range, 1–5) DLIs. The initial median dose was 1.2×106 (range, 0.3×104 – 8×107) consequently being increased up to 4×107 CD3+ cells/kg (range, 1×107 – 1.3×108). As a second stage, 13 non-responding pts as well as those who received no DLIs (transformation to blast phase, n=1; complete loss of donor chimerism, n=3) underwent a 2nd RIC-HSCT. The median interval between 1st and 2nd HSCTs was 17 months (range, 11–77). The majority of the patients received a reduced busulfan/fludarabine conditioning regimen for the 1st HSCT. Conditioning regimen at the 2nd RIC-HSCT for most pts (12/17, 71%) consisted of a combination of treosulfan (30-36 g/m2) with fludarabine (150-180 mg/m2), and anti-thymocyte globuline (Thymoglobulin®, 2.5–8 mg/kg). The majority of pts (15/17, 82%) received 2nd allografts from alternative unrelated (HLA-matched, n=8; mismatched, n=5), related (matched, n=1), and haploidentical donors (n=1). Results: After DLIs, responses were observed in 10/26 pts (39%; complete remission (CR): n=8; CRu (unconfirmed: no bone marrow histology: n=2). All pts maintain the response during a median follow-up of 31 months (range, 13–45). Acute (grade II-IV) and chronic GvHD occurred in 3/26 (12%) and 7/25 (28%) pts, respectively There were no cases of non-relapsed mortality (NRM), while 3/26 pts expired from progression. Seventeen pts received a 2nd RIC-HSCT and engraftment was documented in 16/17 pts (leukocytes: median, d +14; platelets: median, d +18). Responses were observed in 12/15 evaluable pts (80%; CR, n=8; CRu, n=1; partial remission (PR), n=3). Acute (II-IV) and chronic GvHD were observed in 8/17 (47%) and 6/14 pts (43%), respectively. The 1-year cumulative incidence of NRM was 6% (95% CI: 0%-18%). The cumulative incidence of relapse at 1 year was 24% (95% CI: 0%-50%). Overall for whole study population, after a median follow-up of 27 mo (range, 9 – 61), the 2-year probabilities of OS and PFS was 80% (95% CI: 62% - 98%) and 72% (95% CI: 52% - 92%), respectively. Conclusions: DLIs and/or 2nd HSCT are effective and well tolerated salvage approaches, which resulted in the majority of patients in long-term freedom from disease. Disclosures: No relevant conflicts of interest to declare.

e13080 Background: A number of population-based epidemiological studies have been conducted to estimate incidence rates of SPM (newly detected malignancies) among cancer survivors, including those with prostate cancer. However, such data in patients with CRPC are limited. This study was conducted to estimate the incidence of SPM and overall survival (OS) in men with CRPC in the US. Methods: In the SEER-Medicare database, men aged > 65 years with prostate cancer diagnosed in 2000 through 2011 were eligible for the study if they had no other prior malignancy, had surgical or medical castration, and met the protocol-defined criteria for ascertaining castration resistance based on subsequent treatment with any of these therapies: abiraterone, cabazitaxel, docetaxel, enzalutamide, mitoxantrone, or sipuleucel-T. First SPM were identified in Medicare data as 1 inpatient claim, 2 outpatient claims, or 2 physician claims; or in SEER data as 1 diagnosis. Follow-up data ended in 2013. We estimated incidence of SPM as events per 100 person-years (py) with 95% confidence intervals (CI) and survival by the Kaplan-Meier method. Results: Among 2,234 men with CRPC (83.6% white; mean age, 76.6 years; 80.4% with bone metastases), we identified 172 with SPM, of which 20 (11.6%) were in SEER data. The incidence of all first SPM was 5.9 per 100 py (95% CI, 5.0-6.8). The most common of these were lung (n = 29), bladder (n = 22), colorectal (n = 21), other genitourinary cancers (n = 18), and non-colorectal gastrointestinal cancers (n = 17). Mean (SD) time from CRPC ascertainment to SPM was 1.0 (1.1) year. Median OS for the entire study population was 1.2 years (95% CI, 1.1-1.3) after CRPC ascertainment; estimated survival probabilities (95% CI) at 1, 3, and 5 years were 56% (54%-58%), 17% (15%-18%), and 9% (7%-11%), respectively. Conclusions: Most CRPC patients had claims for a diagnosis of bone metastasis when CRPC was ascertained. SPM were common among the study population and occurred relatively soon after CRPC. Most SPM were identified in Medicare rather than SEER data. These results provided context for the incidence of SPM in men with CRPC up to 2013.

The Wood Turtle, Glyptemys insculpta, population at River Denys, Inverness County, Cape Breton Island, Nova Scotia, was unknown except locally until listed in a provincial survey in 1995. Subsequently a hatchling was photographed at McLennan Brook on 17 September 1999, and three adult males were photographed between 14 and 19 September 2000. Two adult females were photographed at South Side River Denys on 18 June 2001. An excavated nest and empty egg shells were located at the same time on a stony-gravel bank at the outflow of McLennan Brook, and one sub-adult male was found at the edge of a hay field on 19 August 2001. Additional observations made of a nesting site and five basking sites, mostly along the main branch of River Denys, provide further evidence that a breeding population of Wood Turtles exists in River Denys watershed.

The aim of this study was to evaluate the recovery of functional status and effectiveness of the second-stage rehabilitation depending on the degree of cognitive impairment in stroke patients. Material and Methods. The study sample comprised 226 stroke patients at the Viršužiglis Hospital of Rehabilitation, Hospital of Lithuanian University of Health Sciences. Functional status was evaluated with the Functional Independence Measure, cognitive function with the Mini-Mental Status Examination scale, and severity of neurologic condition with the National Institutes of Health Stroke Scale. The patients were divided into 4 study groups based on cognitive impairment: severe, moderate, mild, or no impairment. Results. More than half (53%) of all cases were found to have cognitive impairment, while patients with different degree of cognitive impairment were equally distributed: mild impairment (18%), moderate impairment (17%), and severe impairment (18%). Improvement of functional status was observed in all study groups (P<0.001). In the patients with moderate and severe cognitive impairment, cognitive recovery was significantly more expressed than in other study groups (P<0.001). Insufficient recovery of functional status was significantly associated with hemiplegia (OR, 11.15; P=0.015), urinary incontinence (OR, 14.91; P<0.001), joint diseases (OR, 5.52; P=0.022), heart diseases (OR, 4.10; P=0.041), and severe cognitive impairment (OR, 15.18; P<0.001), while moderate and mild cognitive impairment was not associated with the recovery of functional status. Conclusions. During the second-stage rehabilitation of stroke patients, functional status as well as cognitive and motor skills were improved both in patients with and without cognitive impairment; however, the patients who were diagnosed with severe or moderate cognitive impairment at the beginning of second-stage rehabilitation showed worse neurological and functional status during the whole second-stage rehabilitation than the patients with mild or no cognitive impairment.

Abstract Abstract 3323 Poster Board III-211 Allogeneic hematopoietic stem cell transplantation (SCT) for patients who have previously undergone allogeneic or autologous SCT is potentially curative, but dangerous. In order to identify patient, disease and treatment characteristics associated with outcome, we analyzed prognostic factors in 101 consecutive patients who underwent second transplants using allogeneic donors at the Cleveland Clinic between May 1987 and October 2008. Inclusion criteria included age ≥ 18, first SCT either autologous or allogeneic, and second SCT allogeneic. The second transplant was myeloablative (MA) in 65.3% of patients and non-myeloablative (NMA) in 34.7%. Relative to NMA second transplants, patients who underwent MA second transplants were younger (median 34 vs. 45 years, P<0.001), were more likely to have undergone autologous first transplant (34.8% vs. 71.4%, P<0.001), and were more likely to have undergone their second transplant for a diagnosis of acute leukemia (56.1% vs. 17.1%, P<0.001). Patients whose second transplant was MA had higher rates of non-relapse mortality (NRM) (63.5% vs. 28.6%, P=0.008) and shorter survival than patients whose second transplant was NMA (median 3.2 vs. 20.5 months, P<.001; figure). Using recursive partitioning analysis, we found that 17 patients transplanted within 3 months of first transplant had higher NRM (hazard ratio [HR] 4.28, P<0.001) and worse survival (HR 3.03, P<0.001) than those transplanted >3 months after first transplant. 16 of these 17 patients underwent MA second transplant. Among all 17 patients transplanted within 3 months of first transplant, 1 year mortality was 91.4% and median survival was 2.3 months. Death was almost exclusively due to non-relapse causes. In multivariable analysis, we found that relative to undergoing second transplant more than 3 months after first transplant, transplant within 3 months of first transplant carried a higher rate of death and NRM (HR 2.97, P=0.001 and HR 4.58, P<0.001, respectively). Relative to NMA second transplant, MA second transplant carried higher risk of death and NRM (HR 3.69, P<0.001 and HR 4.81, P<0.001, respectively). This difference was also significant for patients transplanted more than 3 months after first transplant (HR 2.68, P<0.001 for death, and HR 3.24, P = 0.002 for NRM). Relative to autologous first transplant, having undergone myeloablative allogeneic first transplant was also prognostic for both death and NRM in multivariable analysis (HR 1.95, P = 0.024 and HR, 2.48, P = 0.018, respectively). Age, gender, diagnosis, disease status, and donor relationship were not prognostic for survival or NRM. Figure: Overall Survival of Second Transplant by Type Figure:. Overall Survival of Second Transplant by Type Kaplan-Meier estimates of overall survival for patients after MA allogeneic second transplant (thick line) or NMA allogeneic second transplant (thin line). We conclude that MA transplantation within 3 months of prior SCT carries an unacceptably high rate of NRM and should not be performed. Despite a lower incidence of relapse, MA second transplants were associated with substantially more NRM and significantly worse survival than NMA second transplants. Disclosures No relevant conflicts of interest to declare.

Abstract Sweet corn was planted at South Deerfield, Mass., on 17 Jun in blocks of 4 rows by 7.6 m with 76 cm between-row and 15 cm in-row spacing. A randomized complete block design with 4 replicates was used. ECB traps (two Heliothis Scentry traps, baited with Trecé lures for Iowa or NY strains) were present from the beginning of the experiment. FAW (Multipher bucket trap with Trecé lure) and CEW traps (Texas wire cone trap, Hereon lure) were both installed on 8 Jul. Traps indicated that second-generation ECB flight began by 3 Aug, and remained strong from 18 Aug until the trial ended. FAW moths were captured only from 22 Jul to 10 Aug. No CEW flight was detected until 31 Aug. Corn was scouted at pretassel on 13 Aug to assess percent infestation with ECB (8 plants/plot from outer 2 rows). Insecticide treatments were initiated on 15 Aug after finding 7.8% infestation of ECB and FAW. Sprays during silking were initiated at 10% silk emergence (20 Aug) and were applied twice weekly on 24, 27, and 31 Aug and 4 Sep.

ABSTRACTIn this study we investigated adopted Chinese girls' expressive English language outcomes in relation to their age at adoption, chronological age, length of exposure to English and developmental risk status at the time of adoption. Vocabulary and phrase utterance data on 318 girls were collected from the adoptive mothers using the Language Development Survey (LDS) (Achenbach & Rescorla, 2000). The girls, aged 18–35 months (M=26·2 months, SD=4·9 months), were adopted at ages ranging from 6·8 to 24 months (M=12·6 months, SD=3·1 months), and had been exposed to English for periods ranging from 1·6 to 27·6 months (M=13·7, SD=5·7). Findings suggest that vocabulary and mean length of phrase scores were negatively correlated with age at adoption but positively correlated with chronological age and length of exposure to English. Developmental risk status at the time of adoption was not correlated with language outcomes. The gap between their expressive language and that of same-age girls from the US normative sample was wider for children aged 18–23 months but was closed for children aged 30–35 months. About 16% of the children met the LDS criteria for delays in vocabulary and 17% met the LDS criteria for delays in mean length of phrase. Speech/language interventions were received by 33·3% of the children with delays in vocabulary and 25% with delays in phrase.

AbstractIt has been suggested that feeding motivation, and hence the incidence of certain abnormal behaviours, may be reduced by the gastro-intestinal distension which results from the ad libitum provision offoods with a high water-holding-capacity (WHO. Therefore, the aim of this experiment was to test the hypothesis that feeding motivation is inversely proportional to the WHC of meals which supply the same level of nutrients. Eight male pigs (initial body weight 54·0 (s.d. 5·76) kg) were offered a series of four foods which possessed increasing WHC due to a linearly increasing inclusion of dried citrus-pulp (2·18, 3·52, 5·60 and 6·92 g water per g dry food for LB, MLB, MHB and HB), but all with similar ratios of digestible energy (DE) to crude protein and minerals. The experimental treatments were allocated in two 4X4 Latin squares with blocks of 6 days separated by a 4-day change-over period. On each day the pigs were given food twice (09.00 h and 16.00 h) to provide the same level of scaled DE across the meals of each treatment. The resulting level offeeding motivation was measured in two successive tests at 30-min intervals before, and eight successive tests at 30-min intervals after, the ingestion of the first meal using a second-order operant conditioning schedule; a methodology which requires pigs to press a paddle to obtain a feeding-related stimuli (CS). It was found that the number ofCS earned pre-feeding was not affected by treatment (17·2, 17·2, 17·6 and 17·5 (s.e.d. 1·58) CS per test for LB, MLB, MHB and HB; P > 0·05), whereas, the number of CS earned post feeding was significantly affected by treatment (16·6, 15·5, 14·6 and 13·8 (s.e.d. 1·15) CS per test for LB, MLB, MHB and HB; P < 0·001). Within each treatment, the number ofCS earned did not alter significantly across any of the time-periods post feeding. As the number of CS earned has been shown to be a reliable indicator of feeding motivation, the results from this experiment support the hypothesis that feeding motivation is inversely proportional to the WHC of iso-energetic meals.

<p><strong>Objective: </strong>The aim of the study was to evaluate the frequency of distal caries in the second molar influenced by the angulation of the third molar adjacent on panoramic radiographs in a clinical dental radiology. <strong>Material and</strong><strong> Methods: </strong>A descriptive and quantitative study that examined 750 panoramic radiographs, of this total, 120 were in accordance with the inclusion criteria of the study was conducted.<strong> Results: </strong>157 seconds and third molars analyzed the prevalence of caries in the distal of the second molar was 25.5%. The most prevalent angle position of the third molar was 57.3% with the vertical, but the position with the highest percentage of decayed molar second distal mesioangular was 50% of the cases. The elements listed, males obtained 40% of second molar distal caries versus 17% for females. People aged 35 or older had the highest incidence with 50% distal caries while other bands obtained 16.21% in the group 18-24 years, and 23.52% in 25-34 years. <strong> Conclusion: </strong>It was possible to establish a sliding scale on the indication for prophylactic removal of mandibular third molar according to the angulation of Winter: horizontal, mesioangular, vertical and distoangular. One can also see a greater relevance to the indication of prophylactic removal of male individuals aged over 35 years.</p>

The aim of this study was to determine MB2 canal detectability in maxillary first and second molars obtained from a Saudi population using micro-CT. Maxillary first (n=35) and second (n=30) molars were scanned with micro-CT technology. The number of canals was recorded, and in case of having more than one canal, the level of extracanal detection was analyzed. The presence of extracanal was categorized based on the level they were first detected. Among the maxillary first molars, 28 (80%) and six (17%) teeth had two and three MB canals, respectively. Among the maxillary second molars, 24 (80%) and four (13%) teeth had two and three MB canals, respectively. The MB2 canal was detected at the chamber floor in 70% and 61% of the maxillary first and second molars, respectively. At 1 mm depth, the MB2 canal was found in 15% and 18% of the maxillary first and second molars, respectively. At 2 mm depth, the MB2 canal was found in 3% and 18% of the maxillary first and second molars, respectively. The remaining teeth had the MB2 canal at levels deeper than 2 mm. The MB2 canal was detected in 97% and 93%% of maxillary first and second molars, respectively. Among them, the MB2 canal could be immediately detected in 70% and 61% of the maxillary first and second molars, respectively, once the pulp chamber is exposed. However, the rest of the MB2 were observed at deeper levels in the root and this requires troughing preparation in the chamber floor.

AbstractSubstantial evidence links socioeconomic status to internalizing and externalizing behavior problems. However, it is unclear how these two categories of behavior problems relate to specific components of socioeconomic status (e.g., income, educational attainment, and occupational prestige) or overall social status. In this study, we conducted a second-order meta-analysis to estimate the average associations of income, education, occupation, and overall socioeconomic status with internalizing and externalizing behavior problems, and to examine if age, sex, and race/ethnicity moderated these associations. Our systematic search in PsycINFO, PubMed, Google Scholar, Web of Science, and ProQuest Dissertations and Theses Global identified 12 meta-analyses (17% unpublished), including approximately 474 primary studies and 327,617 participants. In relation to internalizing, we found small average associations with income,r+= –.18, 95% confidence interval (CI) [–.31, –.04], and education,r+= –.12, 95% CI [–.15, –.09]. In relation to externalizing, we found smaller associations with income,r+= –.02, 95% CI [–.15, .10], education,r+= –.03, 95% CI [–.16, .10], and overall socioeconomic status,r+= –.05, 95% CI [–.11, .01], but these CIs included zero. Only sex composition of the samples moderated the latter association. We provide recommendations for best practices and future research directions.

Objective: To determine caries frequency in mandibular second molars in proportion to level of angulation and depth of impaction of mandibular third molars established on winters and Pell and Gregory classification system. Study Design: This was a Cross-sectional study. Place and Duration of Study: This study was regulated in Department of Oral and Maxillofacial Surgery at Islamic International Dental Hospital, Islamabad from 1 January 2018 to 30th June 2018. Materials and Methods: An overall 100 cases of caries were investigated on clinical and radiographic basis in mandibular second molars. Each panoramic radiograph was studied for the presence of carious lesion in lower second molars. The depth and angulation of impacted third molars was being assessed using Pell and Gregory and winter's grouping respectively. Chi square test was applied for analysis of data. Results: The participants in this study had age range from 18 to 60 years old. Mean age was 39.24 ±9.77 years. Majority of the patients 59 (59.0%) were between the ages 18 and 40. Among these patients, males were 83 (83.0%) and females 17 (17.0%) having a 4.9:1 male-to-female ratio. Caries at the distal aspect of mandibular second molars were seen in 39 percent of individuals with impacted lower third molars and mesioangularly impacted teeth most resulted in caries. Conclusion: This study concluded that 39% of the patients with impacted mandibular third molars caused distal cervical caries in second molars, with mesioangular impaction being the most prominent type causing caries. So, an attentive follow up of impacted mandibular third molars should be considered as health of lower mandibular second molar is influenced by pattern of impaction.

Background The introduction of the partial second toe pulp free flap has enabled superior aesthetic and functional results for fingertip reconstruction in adults. Children undergoing fingertip amputation for various reasons have limited options for reconstruction. Conventional treatment could shorten the finger, leading to poor cosmesis and function. We report 18 years of our experiences with fingertip reconstruction using partial second toe pulp free flaps in patients in early childhood.Methods Medical charts of children who had undergone fingertip reconstruction using partial second toe pulp free flaps from 2001 to 2018 were retrospectively reviewed. The surgical procedures were identical to those for adults, except for the usage of 11-0 nylon sutures. Patients’ demographic data, vessel size, flap dimensions, length of the distal phalanx, and functional outcomes over the course of long-term follow-up were documented. The statistical analysis was performed with the Student t-test, the Mann-Whitney U test, and Pearson correlation analysis.Results Eighteen toe pulp flaps in 17 patients (mean age, 3.0 years) were identified. All the flaps survived without any major complications. In long-term follow-up, the flap-covered distal phalanges showed growth in line with regular development. There was no donor-site morbidity, and all children adapted to daily life without any problems. In two-point discrimination tests, the fingertip sensation recovered to almost the same level as that in the contralateral finger.Conclusions Partial second toe pulp free flaps are an excellent option for fingertip reconstruction in young children, as well as in adults.

Abstract Abstract 781FN2 Introduction: Data on second line therapy with second generation tyrosine kinase inhibitors (TKI) in CML treatment were generated mainly from phase II/III industry initiated trials (Review Hehlmann Exp Op. 2011). 24-month overall survival (OS) varies between 88% and 94% after intolerance and/or resistance to imatinib for chronic phase (CP) and between 67% and 72% for accelerated phase (AP) or blast crisis (BC). Intention to treat analyses including outcome of patients after discontinuation of first line therapies have not been available as yet. We thought to evaluate overall and progression-free survival (OS and PFS) of imatinib intolerant vs. resistant patients under second line TKI with long-term follow-up within an investigator initiated trial. Methods: We analyzed data of the German CML study IV, a randomized 5-arm trial to optimize imatinib therapy on an intention to treat basis. According to protocol, follow-up of patients on and after second generation TKI after imatinib intolerance and/or resistance was continued for OS and PFS. Analysis of PFS was only relevant, if intolerance and resistance to imatinib therapy occurred while a patient was still in chronic phase (CP). Patients were censored at the time of allogeneic stem cell transplantation (allo-SCT). Results: From July 2002 to December 2010, 1,502 patients with Philadelphia chromosome and /or BCR-ABL positive CML in CP were randomized. 129 patients of the “imatinib after interferon arm” and 36 other patients had to be excluded (14 due to incorrect randomization or withdrawal of consent, 22 with missing baseline information). 1337 were randomized to primary imatinib treatment (imatinib 400 mg vs. imatinib 800 mg vs. imatinib in combination with either interferon alpha or araC). Of these, 234 (17%) discontinued imatinib therapy. 156 patients were treated with 2nd generation TKI, 61 were directly referred to allo-SCT, 17 patients received other regimens (including interferon alpha only or hydroxyurea). 120 of 156 patients started second generation TKI therapy (nilotinib, n=41, dasatinib, n=75, bosutinib, n=2, nilotinib and dasatinib, n=2) within 3 months after stopping imatinib, received treatment for at least one week and were evaluable for PFS and OS. 36 patients received second TKI later (median 10 months, range 3.5–61.4). Median age was 50 years (range 16–78), 42.5% were female. 48 patients were intolerant, 48 failed imatinib within CP and 24 after loss of CP (accelerated phase, n=10, blast crisis, n=14). Median time to second generation TKI was 17 months (range 1.4–97 months) and median follow-up after start of second-line TKI 31 months (range 0.2–71 months). Risk stratification according to the EUTOS Score was high in 20 patients (17%) and low in 94 patients (78%) and unknown in 6 patients (5%). OS for all 120 patients 3 years after start of second generation TKI was 73%, 96% for intolerant and 80% for resistant patients in CP and 19% for resistant patients in advanced disease (s. Fig. 1). According to EUTOS score, 3-year OS was 78% for low and 56% for high risk patients. Probability of PFS of the 96 patients in 1st CP after 3 years was 96% for intolerant and 76% for resistant patients. After 2nd generation TKI, 18 patients received an allo-SCT: all were in CP, 2 patients after imatinib intolerance, 16 patients after imatinib resistance. Conclusion: Survival on second generation TKI is high for imatinib intolerant patients in first CP but much lower for resistant patients in first CP or for patients with advanced disease phases. Alternative treatment strategies are warranted for these patient groups. Disclosures: Krause: Micromet: Research Funding. Kneba:Hoffmann La Roche: Honoraria. Hochhaus:Novartis: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding; BMS: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding; Pfizer: Honoraria, Membership on an entity's Board of Directors or advisory committees; Ariad: Consultancy, Membership on an entity's Board of Directors or advisory committees, Research Funding. German CML Study Group:Deutsche Krebshilfe: Research Funding; Novartis: Research Funding; BMBF: Research Funding; EU: Research Funding; Roche: Research Funding; Essex: Research Funding.

Abstract This experiment was conducted in furrow-irrigated corn in Finney County, Kans. Standard and simulated chemigation applications of corn borer insecticides were made to evaluate their efficacy under 2 methods of application. Untreated and miticide-treated (Di-Syston) plots were included as controls. Treatments were arranged in a randomized complete block design with 4 replicates. The plots were 4 rows wide (10 ft) and 45 ft long. The standard insecticide applications were made with a high-clearance sprayer using a 10-ft boom with 3 nozzles directed at each row (one nozzle directly over the row and 2 suspended on 18-inch drop hoses). The sprayer was calibrated to deliver 40 gal/acre with 30 psi of CO2 pressure. The simulated chemigation applications were made using 3 Delvan 100/140, 3/4-inch raindrop nozzles mounted on the high-clearance sprayer at tassel height between the rows. This system was calibrated to deliver 5,400 gal/acre on the 2 center rows (equivalent to a 0.2-inch irrigation). Chemicals were added to 200 gal of water in the main tank of the sprayer and agitated by recirculation and applied within 20 min of mixing. The treatments were applied on 4 Aug and some were retreated on 12 and 17 Aug. The timing of applications was based on the Kansas State University SWCB and ECB models and the presence of corn borer eggs in the field. Evaluations were made 21-27 Sep by dissecting 10 corn plants from each plot (5 consecutive corn plants from each of the 2 center rows). The number of larvae of each species and the length of tunneling was recorded for each plant.

Abstract Background Overall survival (OS) in glioblastoma (GBM) is poor at an average of 14 to 18 months, and long-term survivors (LTS) of GBM are rare. LTS of GBM, defined as surviving >5 years postdiagnosis, represent only 2% to 10% of all GBM patients. LTS of cancer are at high risk of developing second primary neoplasms. This study looks at occurrences of second primary neoplasms in LTS of GBM. Methods Records from adult patients newly diagnosed with GBM between January 1, 1998 and February 8, 2010, were retrospectively reviewed to identify LTS, defined as patients who survived ≥5 years. We focused on the identification of a new diagnosis of cancer occurring at least 2 years after the initial GBM diagnosis. Results We identified 155 LTS of GBM, with a median OS of 11.0 years (95% CI: 9.0 to 13.1 years) and a median follow-up of 9.6 years (95% CI: 8.7 to 10.7 years). In this cohort of patients, 13 (8.4%) LTS of GBM developed 17 secondary cancers. Eight could potentially be attributed to previous radiation and chemotherapy (skin cancer in radiation field [n = 4], leukemia [n = 2], low-grade glioma [n = 1], and sarcoma of the scalp [n = 1]). The other 9 cases included melanoma (n = 2), prostate cancer (n = 2), bladder cancer (n = 1), endometrioid adenocarcinoma (n = 1), basal cell carcinoma (n = 1), and renal cell carcinoma (n = 1). Conclusions Although second primary cancers are rare in GBM LTS, providers should continue close monitoring with appropriate oncologic care. Moreover, this highlights the need for survivorship care of patients with GBM.

AbstractObjectiveTo systematically review the existing evidence regarding the efficacy and safety of phytotherapeutic compounds used to treat men with symptomatic benign prostatic hyperplasia (BPH).DesignRandomized trials were identified searching MEDLINE (1966–1997), EMBASE, Phytodok, the Cochrane Library, bibliographies of identified trials and review articles, and contact with relevant authors and drug companies. The studies were included if men had symptomatic benign prostatic hyperplasia, the intervention was a phytotherapeutic preparation alone or combined, a control group received placebo or other pharmacologic therapies for BPH, and the treatment duration was at least 30 days. Key data were extracted independently by two investigators.ResultsA total of 44 studies of six phytotherapeutic agents (Serenoa repens, Hypoxis rooperi, Secale cereale, Pygeum africanum, Urtica dioica, Curcubita pepo) met inclusion criteria and were reviewed. Many studies did not report results in a method allowing meta-analysis. Serenoa repens, extracted from the saw palmetto, is the most widely used phytotherapeutic agent for BPH. A total of 18 trials involving 2939 men were reviewed. Compared with men receiving placebo, men taking Serenoa repens reported greater improvement of urinary tract symptoms and flow measures. Serenoa repens decreased nocturia (weighted mean difference (WMD)=−0.76 times per evening; 95% CI=−1.22 to −0.32; n=10 studies) and improved peak urine flow (WMD=1.93 ml s−1; 95% CI=0.72 to 3.14, n=8 studies). Men treated with Serenoa repens rated greater improvement of their urinary tract symptoms versus men taking placebo (risk ratio of improvement=1.72; 95% CI=1.21 to 2.44, n=8 studies). Improvement in symptoms of BPH was comparable to men receiving the finasteride. Hypoxis rooperi (n=4 studies, 519 men) was also demonstrated to be effective in improving symptom scores and flow measures compared with placebo. For the two studies reporting the International Prostate Symptom Score, the WMD was −4.9 IPSS points (95% CI=−6.3 to −3.5, n=2 studies) and the WMD for peak urine flow was 3.91 ml s−1 (95% CI=0.91 to 6.90, n=4 studies). Secale cereale (n=4 studies, 444 men) was found to modestly improve overall urological symptoms. Pygeum africanum (n=17 studies, 900 men) may be a useful treatment option for BPH. However, review of the literature has found inadequate reporting of outcomes which currently limit the ability to estimate its safety and efficacy. The studies involving Urtica dioica and Curcubita pepo are limited although these agents may be effective combined with other plant extracts such as Serenoa and Pygeum. Adverse events due to phytotherapies were reported to be generally mild and infrequent.ConclusionsRandomized studies of Serenoa repens, alone or in combination with other plant extracts, have provided the strongest evidence for efficacy and tolerability in treatment of BPH in comparison with other phytotherapies. Serenoa repens appears to be a useful option for improving lower urinary tract symptoms and flow measures. Hypoxis rooperi and Secale cereale also appear to improve BPH symptoms although the evidence is less strong for these products. Pygeum africanum has been studied extensively but inadequate reporting of outcomes limits the ability to conclusively recommend it. There is no convincing evidence supporting the use of Urtica dioica or Curcubita pepo alone for treatment of BPH. Overall, phytotherapies are less costly, well tolerated and adverse events are generally mild and infrequent. Future randomized controlled trials using standardized preparations of phytotherapeutic agents with longer study durations are needed to determine their long-term effectiveness in the treatment of BPH.

Here, we describe Araucariocladus amfractus sp. nov., and compare it to the previously monotypic type-species, A. hiems. The new species can be distinguished from A. hiems by the following combination: colour pattern overall dark-brown; pedicel three times shorter than antennomere III and slightly wider than long; distance between antennal sockets as wide as 3/5 clypeal width; labial palpomere III with sides divergent towards apex, apical margin longer than dorsal and shorter than ventral margin; pronotum 1.5x wider than long, anterior margin somewhat sinuose, with a shallow angle anteriad, posterior margin almost straight. A. amfractus sp. nov. is, prima facie, endemic to the Itatiaia Massif, part of the Mantiqueira Mountain Range, Southeastern Brazil. We provide illustrations of the diagnostic features, and an occurrence map for the Araucariocladus species. Finally, we report a previously unrecognized intra-specific variation in the antennomere numbers of A. hiems, a feature also present in Araucariocladus amfractus sp. nov., and adjust the generic diagnosis to include species with 17 or 18 antennomeres. [Zoobank LSID: urn:lsid:zoobank.org:act:C335B064-FBD4-4256-983D-B17DF06BAA0D]

4540 Background: Up to now the value of 2nd-line therapy for metastatic gastric cancer is unclear. So far there are no randomized phase III data comparing 2nd-line chemotherapy to BSC. Irinotecan has proven activity in 1st-line therapy. In this randomized phase III study we compared irinotecan to BSC to evaluate the value of 2nd- line chemotherapy for gastric cancer. Methods: Prospective multicenter randomized phase III study, open label. Eligibility: Metastatic or locally advanced gastro-esophageal junction or gastric adenocarcinoma. Objective tumor progession (PD) within 6 months after 1st- line chemotherapy. ECOG PS 0–2. Statistics: Primary endpoint: Overall survival (OS). Hypothesis: H1: OS(Irinotecan)>OS(BSC). Calculated number of pts needed (power 80%, alpha error 5%): 60 pts per arm. Stratification for a) PD less versus (vs) more than 3 months after 1st line chemotherapy, b) ECOG PS 0/1 vs 2. Treatment: Arm A: Irinotecan 250mg/m2 q3w (1st cycle) to be increased to 350 mg/m2, depending on toxicity. Arm B: BSC Results: Between Oct 2002 and Dec 2006 40 pts were randomized. The study was closed prematurely due to poor accrual. Arm A:21 pts, arm B 19 pts. Median age A: 58 yrs (43–73), B: 55 yrs (35–72); PD less vs more than 3 months after 1st-line chemotherapy: A: 18 / 3, B: 17 / 2pts. ECOG PS 0/1 vs 2: A: 17/ 4, B: 14/ 5pts. Pre-treatment with cisplatin: A: 21, B:19 pts. Arm A: 68 cycles administered in 21 pts. Toxicity: (main CTC grade 3/ 4): Nausea 1 pt, vomiting 1 pt, diarrhoea: 5 pts, neutropenic fever: 2 pts, data incomplete 6 pts. In 37% of 19 evaluable pts irinotecan dose was escalated to 350mg/m2. Response (19 pts evaluable): No objective responses, SD 58%, PD 42%. Improvement of tumor related symptoms: 44% of pts in arm A, 5% in arm B. Survival: (evaluable pts arm A 21, arm B 18): median survival arm A: 123 days (95%CI 95–216), arm B 72.5 days (95%CI 41–106); OS: HR=2.85 (95%CI 1.41–5.79), Logrank test (two-sided): p=0.0027. Conclusions: To our knowledge this is the first randomized phase III study investigating 2nd- line chemotherapy in gastric cancer. Irinotecan as 2nd-line chemotherapy significantly prolongs overall survival compared to BSC. 2nd-line chemotherapy can now be considered as a proven option in gastric cancer. [Table: see text]

Introduction: To evaluate whether maternal serum α-fetoprotein (MSAFP) improves the detection rate for open neural tube defects (ONTDs) and ventral wall defects (VWD) in patients undergoing first-trimester and early second-trimester fetal anatomical survey. Material and Methods: A cohort of women undergoing screening between 2005 and 2012 was identified. All patients were offered an ultrasound at between 11 weeks and 13 weeks and 6 days of gestational age for nuchal translucency/fetal anatomy followed by an early second-trimester ultrasound at between 15 weeks and 17 weeks and 6 days of gestational age for fetal anatomy and MSAFP screening. All cases of ONTD and VWD were identified via query of billing and reporting software. Sensitivity and specificity for detection of ONTD/VWD were calculated, and groups were compared using the Fisher exact test, with p < 0.05 as significance. Results: A total of 23,790 women met the criteria for inclusion. Overall, 15 cases of ONTD and 17 cases of VWD were identified; 100% of cases were diagnosed by ultrasound prior to 18 weeks' gestation; none were diagnosed via MSAFP screening (p < 0.001). First-trimester and early second-trimester ultrasound had 100% sensitivity and 100% specificity for diagnosing ONTD/VWD. Discussion: Ultrasound for fetal anatomy during the first and early second trimester detected 100% of ONTD/VWD in our population. MSAFP is not useful as a screening tool for ONTD and VWD in the setting of this ultrasound screening protocol.

e19005 Background: MKC-1 is a novel oral cell cycle inhibitor with preclinical activity against NSCLC cell lines including multi-drug resistant lines, and single agent activity in NSCLC pts. Binding targets of MKC-1 include microtubules, members of the importin-β family and AKT-mTOR. This phase 1/2 study evaluated MKC-1 in combination with PEM as second-line therapy in pts with advanced NSCLC. Methods: Eligible pts had NSCLC previously treated with one regimen for metastatic disease or disease progression within one year following adjuvant and neoadjuvant therapy. Phase 1 dose escalation used 3+3 design. Phase 2 pts were treated with MKC-1 at 75 mg/m2 given p.o. BID for 14 days along with PEM at 500 mg/m2 given i.v. on day 1 of each 21 day cycle. Following 4 cycles of combined treatment, single agent MKC-1 was continued as maintenance therapy. An interim analysis after 17 pts in phase 2 would allow accrual to continue provided one response was confirmed. Results: 27 pts were enrolled (8 in phase 1 and 19 in phase 2). Median age/PS for phase 2 is 64/1 and 89% had adenocarcinoma. Total # of treatment cycles to date for phase 2 pts is 95, with a median of 4 cycles. Of the 19 phase 2 pts, 18 were evaluable for tumor response. The best response was confirmed PR, noted in 3 pts. 5 additional pts (4 confirmed) had minor responses (>10% but <30% shrinkage). One additional pt continues on study with stable disease for >18 months. In phase 2 (n=19), all grade toxicities were anorexia (59%), fatigue (63%), nausea (58%), and dyspnea (48%). Grade 3/4 toxicities included fatigue (26%); neutropenia (22%); dyspnea, anorexia, AST and ALT elevation (11% each); nausea and constipation (5% each). 7 pts had at least one dose reduction of both PEM and MKC-1 and 3 additional pts had only MKC-1 reduced. Median PFS was 86 days with two pts continuing on study (treated for 530+ days and 140+ days, respectively). Conclusions: The phase 2 dose of MKC-1 (75 mg/m2 BID) and PEM (500 mg/m2) has been defined. The combination is well tolerated with 17% of patients achieving a confirmed PR thus far. A decision to proceed with additional accrual in this single arm study versus initiating a randomized phase 2 study of this combination is pending. [Table: see text]

Objective.To determine whether second-line intraarticular glucocorticoid (IAGC) injection improves outcomes in children with persistently active Lyme arthritis after initial antibiotics.Methods.We conducted an observational comparative effectiveness study through chart review within 3 pediatric rheumatology centers with distinct clinical approaches to second-line treatment of Lyme arthritis. We primarily compared children receiving second-line IAGC to children receiving a second course of antibiotics alone. We evaluated the risk of developing antibiotic-refractory Lyme arthritis (ARLA) using logistic regression and the time to clinical resolution of Lyme arthritis using Cox regression.Results.Of 112 children with persistently active Lyme arthritis after first-line antibiotics, 18 children received second-line IAGC (13 with concomitant oral antibiotics). Compared to children receiving second-line oral antibiotics alone, children treated with IAGC had similar baseline characteristics but lower rates of ARLA (17% vs 44%; OR 0.3, 95% CI 0.1–0.95; p = 0.04) and faster rates of clinical resolution (HR 2.2, 95% CI 1.2–3.9; p = 0.01). Children in IAGC and oral antibiotic cohorts did not differ in treatment-associated adverse events. Among children receiving second-line IAGC, outcomes appeared similar irrespective of use of concomitant antibiotics. Outcomes were also similar between intravenous (IV) and oral antibiotic-treated cohorts, but older children seemed to respond more favorably to IV therapy. IV antibiotics were also associated with higher rates of toxicity.Conclusion.IAGC injection appears to be an effective and safe second-line strategy for persistent Lyme arthritis in children, associated with rapid clinical resolution and reduced need for additional treatment.

Abstract Autologous HCT (autoHCT) salvages many patients (pts) with relapsed lymphomas but few relapsing after an autoHCT are cured. We determined feasibility of stem cell collection, engraftment kinetics, treatment-related mortality (TRM), progression free survival (PFS), and overall survival (OS) for a second autoHCT (HCT2) for lymphoma relapsing after prior HCT (HCT1). We studied 35 pts, 20 with HL and 15 with diffuse or follicular large cell and immunoblastic NHL, receiving a HCT2 for relapse between 1986 and 2003 and reported to the CIBMTR. Median (range) age at HCT2 was 36 yrs (16–61); 61% had a performance score less than 90. HCT2 was performed >1 year after HCT1 in 80%. Median (range) time from diagnosis to HCT1 was 20 mo (4–162 mo), from HCT1 to relapse, 17 mo (3–68 mo), and from relapse to HCT2, 5 mo (1–40 mo). 83% underwent a 2nd stem cell / marrow harvest prior to HCT2. Median time to ANC >0.5 x 109/L was 11d. CBV or BEAM were the conditioning regimens for HCT1 in 80% and for HCT2 in 60%. The best response to HCT2 was complete remission in 22 pts and partial remission in 5; 8 pts had either no response or progressive disease. At a median follow up of 92 mo (32–124 mo) after HCT2, 26 pts (74%) have died with 17 (65%) dying of relapsed lymphoma. Two (6%) patients developed therapy-related MDS. The probability of TRM at day 100 was 12% (95% CI, 3–25%). The 1, 3 and 5 yr probability of PFS were 45% (95% CI, 29–62%), 33% (95% CI, 18–50%) and 30% (95% CI, 15–46%), respectively. The 1, 3 and 5 yr probability of OS were 63% (95% CI, 46–78%), 34% (95% CI, 19–50%) and 31% (95% CI, 17–47%), respectively. There were no differences in outcomes between HL or NHL. Pts relapsing >6mo after HCT1 appeared to have better OS (fig 1 and 2). In summary, HCT2 is feasible in pts with lymphoma after relapsing an HCT1. Stem cells harvested prior to HCT2 resulted in rapid engraftment with a day 100 TRM (12%) lower than that reported for alloHCT in this setting. Relapse is the primary reason for failure, but approximately one-third of pts enjoy long-term disease free survival. HCT2 should be considered for young pts with relapsed HL or NHL post-HCT1 without alternative transplant options. HCT1 (%) HCT2 (%) Sensitive disease status pre-HCT 26 (79) 24 (75) Stem cell source BM 15 (43) 10 (29) PBSC 13 (37) 21 (60) Both 7 (20) 4 (11) Median days to platelet recovery ≥ 20 x 109 /L 17 (7–376) 20 (1–101) Stem cell harvest between HCT1 and HCT2 29 (83) Different conditioning regimen for HCT2 25 (74) Outcomes TRM @ 1 yr 21 (9–37) PFS @ 5yrs 30 (15–46) OS @ 5 yrs 31 (17–47) Figure 1 Figure 1. Figure 2 Figure 2.

Abstract Second allogeneic hematopoietic cell transplant (HCT) may be indicated for relapsed hematological malignancies or graft failure. However, there are limited data in the literature concerning outcome post second allogeneic HCT. The purpose of the presented study was to investigate parameters that may influence outcome post second allogeneic HCT. This single centre retrospective study at the Princess Margaret Cancer Centre examined 92 patients that underwent second HCT from 1980-2015. First HCT was done for patients with median age 35 years (range 9-68), for various hematological diseases (AML 26 patients, CML 28 patients, aplastic anemia 14 patients, ALL 11 patients, other diseases 13 patients). Donors were related for 78 patients (85%) versus unrelated for 14 (15%). Graft was bone marrow for 71 patients (77%) versus peripheral blood stem cells (PBSC) for 21 (23%). For the second HCT, median age was 40 years (range 16-69, age ≤40 n=46, >40 n=46). The indication for second HCT was either relapsed hematologic malignancy for 59 patients (64%, 12 patients relapsed ≤6 months post first HCT), versus graft failure for 33 patients (36%). The median time from first HCT until relapse or graft failure was 11 months (1-206 months). The median time from first HCT until second HCT was 18 months (range 1-212). Year second HCT was performed was grouped into 1980-1995 (n=28), 1996-2005 (n=42), 2006-2015 (n= 22). Fifty-two patients (57%) had ECOG 0-1 versus 40 patients (43%) with ECOG 2-3. Preparative regimen was myeloablative (MA) for 47 (51%) versus 45 with other regimens (49%). Calcineurin inhibitor-based GVHD prophylaxis was used in 75 patients (82%). Eighty-three patients (90%) used the same donor versus only 9 patients (10%) which had a different donor. The type of graft at second HCT was PBSC in 54 patients (59%) versus BM for 38 patients (41%). Among the 82 patients with count recovery data, median neutrophil count ≥0.5/µL was 18 days (range 8-54), and platelet recovery ≥20/µL was 16 days (range 10-88). Among the 66 patients that died, cause of death was relapse in 17 patients (26%), infection in 18 patients (27%), GVHD in 6 patients (9%), graft failure in 6 patients (9%) and other complications in 19 patients (29%). Median follow up of survivors was 120 months (range 5-286). Three-year overall survival (OS) of the entire cohort was 35% (95% CI=25-45) (Figure 1). Univariate analysis for OS examined second HCT indication (3-year OS 43% for relapse versus 20% for graft failure, p=0.02), ECOG score (3-year OS 48% for ECOG 0-1 versus 18% for ECOG ≥2, p=0.0006, Figure 2), time from first HCT to relapse/graft failure (3-year OS for <12 months 21% versus ≥12 months 46%, p=0.009), preparative regimens (3-year OS for MA 42% versus other regimens 23%, p=0.08). Age at second HCT (≤40 versus >40 years, p=0.2), time period second HCT was performed (p=0.7), use of different donor (p=0.3) and graft source for second HCT (p=1.0) were not significant. Multivariable analysis for OS demonstrated ECOG score at second HCT (HR=2.15 for ECOG ≥2, 95% CI=1.32-3.51, p=0.002) and indication for second HCT (HR=1.67 for graft failure, 95%CI=1.02-2.75, p=0.04) to be the only independent prognostic variables influencing survival in this cohort. In conclusion, second HCT may provide prolonged survival, particularly for patients transplanted for relapsed disease following first HCT, and with a favorable performance status. Disclosures Lipton: Pfizer: Consultancy, Research Funding; Novartis: Consultancy, Research Funding; BMS: Consultancy, Research Funding; Ariad: Consultancy, Research Funding.

Abstract Abstract 1701 Mutations within the BCR-ABL domain are the most frequent mechanism of imatinib (IM) resistance. The second generation inhibitors (SGI) are indicated for imatinib intolerance or resistance and the initials trials showed similar response rates in IM resistant patients after IM failure, independent of mutation status, with exception of T315I. The aim of this work was to report the frequency of BCR-ABL mutations in chronic myeloid leukemia (CML) patients of a Latin American population and to evaluate the clinical impact of the presence and type of mutations in overall survival (OS), progression free survival (PFS) and in the response to second generation inhibitors (SGI). Methods: retrospective analysis of 17 centers from Latin America. A total of 529 CML patients with mutation analysis performed in samples collected between 2002 and 2011 were included. Mutations were detected by direct sequencing from bone marrow or peripheral blood samples, collected from CML patients. After imatinib resistance, patients were treated with SGI (69%) or other treatments. Overall survival (OS) was calculated from date of mutation detection until last follow-up or death, and progression-free survival (PFS) from date of mutation detection until progression to accelerated phase or blast crisis, last follow-up or death. Survival curves were calculated using the log-rang test (SPSS 14.0 software).Results: the median age of patients at diagnosis was 45 years (5–87). 81% were in chronic phase (CP), 13% in accelerated phase (AP), 6% in blast crisis (BC). According to Sokal score, patients were stratified in low (36%), intermediate (30%) and high risk (34%); 36% had previously used Interferon. The median time from diagnosis until Imatinib treatment was 8 months (0–310) and from Imatinib start until mutation detection was 31 months (1–104). Mutations were found in 188 patients, in the following sites: P-loop (75/40%), nucleotide contact site (34/18%), catalytic domain (44/23%), A-loop (11/6%) and others (24/13%). The most frequent mutations detected were: T315I (30/16%), F359V/C/I (27/14%), M244V (18/9.6%), E255K/V (17/9%), G250E (17/9%), Y253H/F/Y (15/8%), M351T/L (12/6%); Ten patients presented concomitant mutations. On dasatinib treatment 29 mutations (27% T315I) were detected whereas 18 during nilotinib (16.5% T315I). Overall survival in the total group was 61% (95%CI: 51–71%) with a median time of 12 months. There was a significant difference in OS and PFS between non-mutated and mutated patients (76% vs 44% and 64% vs 44% respectively (P= 0.008 and P= 0.001). There was no difference in survival comparing P-loop mutations and others, excluding T315I. Patients with T315I mutations had a poorer outcome in comparison with other mutations (OS 21% vs 62%; PFS 35% vs 55%) (P= 0.04 and 0.06, respectively). In the group with BCR-AL mutations, OS was superior in patients that received a SGI in comparison with other treatments after resistance (50% vs 36% P= 0.007). One hundred patients (19%) died due to: disease progression (72), infections (8), graft versus host disease (2), central nervous system bleeding (2), cardiac failure (1), second neoplasia (1). 14 causes were not reported. Conclusions: Patients with BCR-ABL mutations had an inferior OS and PFS. T315I mutations were associated to a poor outcome. Treatment with SGI prolonged survival of patients after imatinib failure. Disclosures: Pagnano: Novartis: Speakers Bureau; Bristol Myers Squibb: Speakers Bureau. Boquimpani:Novartis: Speakers Bureau; Bristol Myers Squibb: Speakers Bureau. Pasquini:Novartis: Membership on an entity's Board of Directors or advisory committees, Speakers Bureau; Bristol Myers Squibb: Speakers Bureau. Spector:Novartis: Membership on an entity's Board of Directors or advisory committees.