Littérature scientifique sur le sujet « RNA-Targeted small molecules »
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Articles de revues sur le sujet "RNA-Targeted small molecules"
Costales, Matthew G., Haruo Aikawa, Yue Li, Jessica L. Childs-Disney, Daniel Abegg, Dominic G. Hoch, Sai Pradeep Velagapudi et al. « Small-molecule targeted recruitment of a nuclease to cleave an oncogenic RNA in a mouse model of metastatic cancer ». Proceedings of the National Academy of Sciences 117, no 5 (21 janvier 2020) : 2406–11. http://dx.doi.org/10.1073/pnas.1914286117.
Texte intégralNagano, Konami, Takashi Kamimura et Gota Kawai. « Interaction between a fluoroquinolone derivative and RNAs with a single bulge ». Journal of Biochemistry 171, no 2 (16 novembre 2021) : 239–44. http://dx.doi.org/10.1093/jb/mvab124.
Texte intégralSun, Saisai, Jianyi Yang et Zhaolei Zhang. « RNALigands : a database and web server for RNA–ligand interactions ». RNA 28, no 2 (3 novembre 2021) : 115–22. http://dx.doi.org/10.1261/rna.078889.121.
Texte intégralTadesse, Kisanet, et Raphael I. Benhamou. « Targeting MicroRNAs with Small Molecules ». Non-Coding RNA 10, no 2 (14 mars 2024) : 17. http://dx.doi.org/10.3390/ncrna10020017.
Texte intégralWu, Liping, Jing Pan, Vala Thoroddsen, Deborah R. Wysong, Ronald K. Blackman, Christine E. Bulawa, Alexandra E. Gould et al. « Novel Small-Molecule Inhibitors of RNA Polymerase III ». Eukaryotic Cell 2, no 2 (avril 2003) : 256–64. http://dx.doi.org/10.1128/ec.2.2.256-264.2003.
Texte intégralAngelbello, Alicia J., Suzanne G. Rzuczek, Kendra K. Mckee, Jonathan L. Chen, Hailey Olafson, Michael D. Cameron, Walter N. Moss, Eric T. Wang et Matthew D. Disney. « Precise small-molecule cleavage of an r(CUG) repeat expansion in a myotonic dystrophy mouse model ». Proceedings of the National Academy of Sciences 116, no 16 (29 mars 2019) : 7799–804. http://dx.doi.org/10.1073/pnas.1901484116.
Texte intégralAlagia, Adele, Jana Tereňová, Ruth F. Ketley, Arianna Di Fazio, Irina Chelysheva et Monika Gullerova. « Small vault RNA1-2 modulates expression of cell membrane proteins through nascent RNA silencing ». Life Science Alliance 6, no 6 (10 avril 2023) : e202302054. http://dx.doi.org/10.26508/lsa.202302054.
Texte intégralFrancois-Moutal, Liberty, David Donald Scott et May Khanna. « Direct targeting of TDP-43, from small molecules to biologics : the therapeutic landscape ». RSC Chemical Biology 2, no 4 (2021) : 1158–66. http://dx.doi.org/10.1039/d1cb00110h.
Texte intégralSmola, Matthew J., Krista Marran, Sarah E. Thompson, Brittani Patterson, Roheeth K. Pavana, Caleb Sutherland, Jessica A. Sorrentino et Katherine D. Warner. « Abstract 680 : Leveraging an RNA-targeting platform for the discovery of cell-active c-MYC mRNA-binding small molecules ». Cancer Research 84, no 6_Supplement (22 mars 2024) : 680. http://dx.doi.org/10.1158/1538-7445.am2024-680.
Texte intégralMirón-Barroso, Sofía, Joana S. Correia, Adam E. Frampton, Mark P. Lythgoe, James Clark, Laura Tookman, Silvia Ottaviani et al. « Polymeric Carriers for Delivery of RNA Cancer Therapeutics ». Non-Coding RNA 8, no 4 (2 août 2022) : 58. http://dx.doi.org/10.3390/ncrna8040058.
Texte intégralThèses sur le sujet "RNA-Targeted small molecules"
Panei, Francesco Paolo. « Advanced computational techniques to aid the rational design of small molecules targeting RNA ». Electronic Thesis or Diss., Sorbonne université, 2024. http://www.theses.fr/2024SORUS106.
Texte intégralRNA molecules have recently gained huge relevance as therapeutic targets. The direct targeting of RNA with small molecule drugs emerges for its wide applicability to different classes of RNAs. Despite this potential, the field is still in its infancy and the number of available RNA-targeted drugs remains limited. A major challenge is constituted by the highly flexible and elusive nature of the RNA targets. Nonetheless, RNA flexibility also presents unique opportunities that could be leveraged to enhance the efficacy and selectivity of newly designed therapeutic agents. To this end, computer-aided drug design techniques emerge as a natural and comprehensive approach. However, existing tools do not fully account for the flexibility of the RNA. The project of this PhD work aims to build a computational framework toward the rational design of compounds targeting RNA. The first essential step for any structure-based approach is the analysis of the available structural knowledge. However, a comprehensive, curated, and regularly updated repository for the scientific community was lacking. To fill this gap, I curated the creation of HARIBOSS ("Harnessing RIBOnucleic acid - Small molecule Structures"), a database of all the experimentally-determined structures of RNA-small molecule complexes retrieved from the PDB database. HARIBOSS is available via a dedicated web interface (https://hariboss.pasteur.cloud), and is regularly updated with all the structures resolved by X-ray, NMR, and cryo-EM, in which ligands with drug-like properties interact with RNA molecules. Each HARIBOSS entry is annotated with physico-chemical properties of ligands and RNA pockets. HARIBOSS repository, constantly updated, will facilitate the exploration of drug-like compounds known to bind RNA, the analysis of ligands and pockets properties and, ultimately, the development of in silico strategies to identify RNA-targeting small molecules. In coincidence of its release, it was possible to highlight that the majority of RNA binding pockets are unsuitable for interactions with drug-like molecules, attributed to the lower hydrophobicity and increased solvent exposure compared to protein binding sites. However, this emerges from a static depiction of RNA, which may not fully capture their interaction mechanisms with small molecules. In a broader perspective, it was necessary to introduce more advanced computational techniques for an effective accounting of RNA flexibility in the characterization of potential binding sites. In this direction, I implemented SHAMAN, a computational technique to identify potential small-molecule binding sites in RNA structural ensembles. SHAMAN enables the exploration of the target RNA conformational landscape through atomistic molecular dynamics. Simultaneously, it efficiently identifies RNA pockets using small probe compounds whose exploration of the RNA surface is accelerated by enhanced-sampling techniques. In a benchmark encompassing diverse large, structured riboswitches as well as small, flexible viral RNAs, SHAMAN accurately located experimentally resolved pockets, ranking them as preferred probe hotspots. Notably, SHAMAN accuracy was superior to other tools working on static RNA structures in the realistic drug discovery scenario where only apo structures of the target are available. This establishes SHAMAN as a robust platform for future drug design endeavors targeting RNA with small molecules, especially considering its potential applicability in virtual screening campaigns. Overall, my research contributed to enhance our understanding and utilization of RNA as a target for small molecule drugs, paving the way for more effective drug design strategies in this evolving field
Chung, Janet. « Investigation of small molecule - SL1 RNA interactions and implications in drug design targeted at HIV-1 genomic dimer maturation ». Diss., Search in ProQuest Dissertations & ; Theses. UC Only, 2009. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3390040.
Texte intégralLivres sur le sujet "RNA-Targeted small molecules"
Slabý, Ondřej. MicroRNAs in solid cancer : From biomarkers to therapeutic targets. Hauppauge, N.Y : Nova Science, 2011.
Trouver le texte intégralChapitres de livres sur le sujet "RNA-Targeted small molecules"
Fladung, Matthias, Hely Häggman et Suvi Sutela. « Application of RNAi technology in forest trees. » Dans RNAi for plant improvement and protection, 54–71. Wallingford : CABI, 2021. http://dx.doi.org/10.1079/9781789248890.0007.
Texte intégralFladung, Matthias, Hely Häggman et Suvi Sutela. « Application of RNAi technology in forest trees. » Dans RNAi for plant improvement and protection, 54–71. Wallingford : CABI, 2021. http://dx.doi.org/10.1079/9781789248890.0054.
Texte intégralUrsu, Andrei, Matthew G. Costales, Jessica L. Childs-Disney et Matthew D. Disney. « Chapter 15. Small-molecule Targeted Degradation of RNA ». Dans Protein Degradation with New Chemical Modalities, 317–36. Cambridge : Royal Society of Chemistry, 2020. http://dx.doi.org/10.1039/9781839160691-00317.
Texte intégralDamski, Caio, et Kevin V. Morris. « Targeted Small Noncoding RNA-Directed Gene Activation in Human Cells ». Dans Methods in Molecular Biology, 1–10. New York, NY : Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4939-0931-5_1.
Texte intégralWilson, W. David, et Ananya Paul. « Reversible Small Molecule–Nucleic Acid Interactions ». Dans Nucleic Acids in Chemistry and Biology, 477–521. The Royal Society of Chemistry, 2022. http://dx.doi.org/10.1039/9781837671328-00477.
Texte intégralOktay, Yavuz. « Metabolomiks ve Uygulamaları ». Dans Moleküler Biyoloji ve Genetik, 311–28. Türkiye Bilimler Akademisi, 2023. http://dx.doi.org/10.53478/tuba.978-625-8352-48-1.ch12.
Texte intégralHampson, Ian, Gavin Batman et Thomas Walker. « RNA interference technology ». Dans Tools and Techniques in Biomolecular Science. Oxford University Press, 2013. http://dx.doi.org/10.1093/hesc/9780199695560.003.0006.
Texte intégralIqbal, Nashra, Priyanka Vishwakarma et Vidya Meenakshi. « NEXT GENERATION SEQUENCING FOR CANCER DIAGNOSIS ». Dans Futuristic Trends in Biotechnology Volume 3 Book 21, 137–51. Iterative International Publishers, Selfypage Developers Pvt Ltd, 2024. http://dx.doi.org/10.58532/v3bkbt21p1ch11.
Texte intégralScarpino, Stefania, et Umberto Malapelle. « Liquid Biopsy : A New Diagnostic Strategy and Not Only for Lung Cancer ? » Dans Histopathology and Liquid Biopsy [Working Title]. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.94838.
Texte intégralActes de conférences sur le sujet "RNA-Targeted small molecules"
Kahen, Elliot J., Darcy Welch, Jamie Teer, Andrew S. Brohl, Sean J. Yoder, Yonghong Zhang, Ling Cen et Damon Reed. « Abstract 3010 : Osteosarcoma cell lines display both shared and unique vulnerabilities to 140 targeted small molecules with RNA-seq revealing putative mechanisms ». Dans Proceedings : AACR Annual Meeting 2019 ; March 29-April 3, 2019 ; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.am2019-3010.
Texte intégralKahen, Elliot J., Darcy Welch, Jamie Teer, Andrew S. Brohl, Sean J. Yoder, Yonghong Zhang, Ling Cen et Damon Reed. « Abstract 3010 : Osteosarcoma cell lines display both shared and unique vulnerabilities to 140 targeted small molecules with RNA-seq revealing putative mechanisms ». Dans Proceedings : AACR Annual Meeting 2019 ; March 29-April 3, 2019 ; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.sabcs18-3010.
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