Thèses sur le sujet « Right PPC »

La Stimolazione transcranica a Corrente Diretta continua (tDCS) è una tecnica di neurostimolazione non invasiva in grado di generare alterazioni dell’eccitabilità neuronale dipendenti dalla plasticità. Negli ultimi anni si sta assistendo a un crescente interesse nell’utilizzo di questa tecnica, sia in settings clinici che sperimentali. In particolare, la possibilità di indurre effetti a lungo termine rende la tDCS interessante nel trattamento di deficit cognitivi associati a disturbi sia neuropsicologici che psichiatrici. Nonostante la sua crescente diffusione, si sa ancora poco riguardo i meccanismi neurofisiologici alla base del suo funzionamento, soprattutto per quanto riguarda gli effetti su regioni cerebrali che sottostanno a funzioni cognitive di ordine superiore. Una conoscenza più approfondita dei meccanismi alla base della tDCS potrebbe quindi essere cruciale per riuscire a definire e migliorare i protocolli di stimolazione sia clinici che di ricerca. A questo scopo, uno studio sistematico degli effetti corticali della tDCS appare ancora più necessario. In questo progetto abbiamo quindi esplorato gli effetti di plasticità corticale indotti dalla stimolazione catodica in soggetti sani, sia a riposo che durante l’esecuzione di un compito, utilizzando il sistema integrato di Stimolazione Magnetica Transcranica ed Elettroencefalografia (TMS-EEG). Il TMS-EEG è una tecnica molto efficace in quando permette di misurare direttamente la modulazione dell’eccitabilità corticale su tutta la corteccia. In questa tesi sono riportati tre studi. Nel primo, partendo dai risultati sulla tDCS anodica già precedentemente pubblicati, sono stati esplorati gli effetti della tDCS catodica sulla Corteccia Parietale Posteriore (PPC) destra a riposo. Nel secondo studio, abbiamo indagato gli effetti comportamentali indotti dalla tDCS catodica sulla PPC destra, durante l’esecuzione di due compiti: uno di memoria di lavoro visuospaziale e uno di orientamento dell’attenzione visuospaziale. Nel terso studio, infine, abbiamo utilizzato nuovamente il TMS-EEG per tracciare gli effetti neurofisiologici della tDCS catodica sulla PPC di destra mentre i partecipanti erano impegnati nell’esecuzione dei compiti individuati nello studio precedente. I risultati per la tDCS catodica a riposo non hanno mostrato effetti di modulazione dell’eccitabilità corticale, sia a livello dei sensori che a livello delle sorgenti, sia a livello locale che globale. I risultati precedentemente ottenuti con la tDCS anodica, hanno invece mostrato un aumento diffuso dell’eccitabilità corticale lungo un network bilaterale frontoparietale, che rispecchia le connessioni strutturali tra le aree d’interesse. Durante l’esecuzione di un compito, invece, la stimolazione catodica, così come quella anodica, ha mostrato una modulazione nell’eccitabilità corticale solo in quelle aree che sono coinvolte nell’esecuzione del compito. In conclusione, in questo lavoro di tesi emergono diversi interessanti risultati. Innanzitutto, questi dati mostrano un effetto non lineare della tDCS sull’eccitabilità corticale a riposo, che non possono essere completamente spiegati dal semplice dualismo anodico-eccitatorio catodico-inibitorio. Un altro risultato rilevante è dato dal ruolo cruciale giocato dai differenti stati ti attivazione corticale (a riposo Vs attivo). Questi risultati sembrano mostrare che il livello di attivazione corticale di base contribuisca a modulare gli effetti della stimolazione, in accordo con l’ipotesi “attività-selettività”. Lo stato di attivazione di base deve quindi essere preso in considerazione, in particolare se si vogliono osservare degli effetti di neuromodulazione con tDCS catodica. In generale, tutte queste osservazioni contribuiscono a costruire quel corpus di conoscenze necessario soprattutto per la definizione dei parametri tDCS sia per esperimenti di neuroscienze cognitive che per protocolli riabilitativi.<br>Transcranial direct current stimulation (tDCS) is a non-invasive neuromodulatory technique able to induce plasticity-related alterations in neuronal excitability. There is a growing interest in the use of tDCS in both experimental and clinical settings; in particular, the chance to induce long-term effects fostered the used of the technique to treat cognitive impairments associated with different neuropsychological and psychiatric disorders. Although tDCS is increasingly used, presently little is still known about its neurophysiological underpinnings, particularly concerning the activity on the brain regions that underlie high cognitive brain functions. In these cases, optimal tDCS stimulation parameters also have yet to be clearly defined. A deeper understanding of the mechanisms underpinning this technique would be crucial to achieving a better refinement of stimulation protocols for clinical and research purposes. For this reason, a systematic and comprehensive study of its cortical effects acquires a critical relevance. In the last years, there has been indeed a keen interest in understanding the working mechanisms of this technique. To address this issue, in this project we explored the cortical plasticity modulation induced by cathodal stimulation on healthy subjects while resting or during task execution, using an integrated system of Transcranial Magnetic Stimulation and Electroencephalography (TMS-EEG), which allows to directly measure cortical excitability modulation all over the cortex and effective connectivity. In the first study, starting from the previous results with anodal tDCS, the effects of cathodal stimulation over the right Posterior Parietal Cortex (PPC) were explored during resting state. The contralateral homologue brain area, namely the left posterior parietal cortex (PPC), was targeted with TMS before, during, and after cathodal stimulation. In the second study, we explored the behavioural effects induced by the application of cathodal tDCS over right PPC during the execution of two tasks, one of visuospatial working memory and a second tapping visual attention reorienting, which are known to involve this brain area. The aim was to find tasks sensitive to the effect of cathodal tDCS over the right PCC, to be used in the third study. A disruption of the performance was found for the Posner Cueing Task. In the third study, we employed again TMS-EEG to track the neurophysiological effects of cathodal tDCS on right PPC at an active state, i.e. while the participants were performing the task tested on the second study. The results at resting state for cathodal tDCS, both at sensors and cortical sources levels, converge in showing no differences during and after tDCS compared to pre-stimulation sessions, both at a global and local level. The previous results with anodal tDCS, instead, reported a widespread rise of cortical excitability along with a bilateral frontoparietal network, following structural connections. On the other hand, at an active state, cathodal, as well as anodal, tDCS induced modulation of cortical excitability only in the task-relevant brain regions. Several significant findings emerged from this empirical work. First of all, these data highlight a non-linear impact of anodal and cathodal stimulation on cortical excitability at rest that is not depicted by the simplistic view of anodal-excitatory and cathodal-inhibitory effects. Another relevant point is the crucial role played by the different cortical states (resting vs active). These results seem to point out that the level of cortical state can contribute to modulate the tDCS effects, in line with “activity-selectivity” hypothesis. The level of cortical state needs to be taken into account, especially to observe neuromodulatory effects also with cathodal tDCS. All these findings hold relevant implications for tDCS setup in both cognitive neuroscience experiments and rehabilitation protocols.

Esta dissertação analisa a trajetória do Partido Progressista Brasileiro (PPB), atualmente rebatizado de Partido Progressista (PP), desde a época do regime militar, sob a denominação de ARENA. O trabalho investiga o desempenho eleitoral e as estratégias que o partido vem utilizando para sobreviver em um ambiente democrático e multipartidário. Nascido dentro do Estado no período autoritário o PPB enfrentou uma série de dificuldades para manter-se com a transição para a democracia. O partido que nasceu grande e descentralizado vem ao longo do tempo assumindo outro perfil: um partido menor e mais centralizado. Apesar de ter perdido influência o PPB têm se mantido entre os maiores partidos do Brasil concentrando cerca de 10% dos cargos políticos em disputa. O trabalho trata também dos deputados, federais e estaduais, do PPB, analisando o posicionamento destes acerca de questões importantes para a política nacional.<br>This dissertation analyses the trajectory of the Brazilian Progressive Party (recently renamed of Progressive Party - PP), since its creation during the military regimen under the denomination of ARENA (Renovadora National Alliance). The work investigates the electoral performance and the strategies developed by the party to survive under a democratic and multiparty environment. Having been born within of the State, BPP faced many difficulties to survive after the end of the authoritarian regime. After having developed a large and decentralized struture, this party have changed into: a centralized and small organization. Although having lost most of its influence, the BPP has kept its position among the largest parties concentrating about 10% of the elected offices in the country. The work also examines the BPP´s members of the houses of representatives, analysing their positioning regarding important issues of Brazilian policy.

L’asymétrie Droite-Gauche (DG) est responsable de l’empaquetage et l’enroulement stéréotypé des organes internes au cours du développement. Chez la Drosophile, l’intestin postérieur adulte (AHG) se développe asymétriquement selon l’axe DG en formant une boucle dextrale. Comme pour tous les organes asymétriques DG de la Drosophile, la mise en place de l’axe DG nécessite l’expression de la myosine non conventionnelle de type I : MyoID. Cette myosine se lie à la DE-Cadherine au niveau des jonctions adhérentes (AJ) pour mettre en place l’axe DG, mais le mécanisme moléculaire qui transforme la chiralité de MyoID en une morphogenèse asymétrique DG est totalement inconnu. Le AHG est un long tube situé au milieu de l’abdomen, qui présente une boucle dextrale dans sa partie proximale. Il se développe à partir d’un groupe de progéniteurs formés de deux populations de cellules : H1 et H2. Dans cette étude, nous avons mis en évidence que MyoID contrôle la formation de la boucle dextrale du AHG grâce à son interaction avec la cadhérine atypique Dachsous dans les cellules H1. De plus, nous avons pu mettre en évidence que la signalisation Dachsous-Fat est activée à travers les cellules H2 entrainant leur polarisation du coté droit, et ainsi formant l’enroulement du AHG. Les cellules H1 sont transitoires, elles disparaissent lors des premières heures de la métamorphose. Cependant, l’information dextrale générée dans les cellules H1 perdure dans les cellules H2 grâce à l’action coordonnée des composants de la polarité planaire. Nous montrons que la polarité planaire contrôle l’établissement de l’asymétrie DG en aval de MyoID, en transmettant l’information DG dans le AHG<br>Stereotyped left right (LR) asymmetry ensures proper looping of internal organs. In Drosophila, the adult hindgut (AHG) has a clear stereotypical dextral loop and, like all LR asymmetric organs, require MyoID for correct orientation. MyoID is an unconventional myosin type I that binds to DE-Cadherin, this association is required for proper LR establishment; however the mechanism that translates MyoID chirality into proper morphogenesis remains unknown. The AHG is a long tube coiled dextrally and located in the middle of the abdominal region. It develops from a cluster of progenitors containing two different populations of cells, H1 and H2. Here, we show that MyoID controls the AHG dextral loop by binding to the atypical cadherin Dachsous in H1 cells. Further, Ds-Fat signaling propagates towards the H2 cells which in turn become polarized towards the right and consequently loop. H1 is a transient population of cells that wear off in the first hours of metamorphosis; nevertheless the dextral information generated in H1 is maintained in H2 cells due to the cooperative action of PCP components. We demonstrate that the molecular basis of the LR establishment downstream of MyoID action lies in the PCP system, which has a double role transmitting and maintaining a dextral signal in the AHG. Thus, we provide for the first time a link in L/R morphogenesis between Drosophila and vertebrates in which PCP mutants result in L/R defects. Furthermore, in our attempts to better understand the evolution of L/R morphogenesis we found the recently co-Appearance of a myoID cis-Regulatory element and the AHG dextral loop, during Drosophila evolution, suggesting that changes in myoID express

Right ventricular dysfunction is the most frequent cause of death in patients with pulmonary arterial hypertension. Although abnormal energy substrate use has been implicated in the development of chronic left heart failure, data describing such metabolic remodeling in failing right ventricular tissue remain incomplete. In the present dissertation we sought to characterize metabolic gene expression changes and mitochondrial dysfunction in functional and dysfunctional RV hypertrophy. Two different rat models of RV hypertrophy were studied. The model of right ventricular failure (SU5416/hypoxia) exhibited a significantly decreased gene expression of peroxisome proliferator-activated receptor- coactivator-1α, peroxisome proliferator- activated receptor-α and estrogen-related receptor-α. The expression of multiple peroxisome proliferator-activated receptor- coactivator-1α target genes required for fatty acid oxidation was similarly decreased. Decreased peroxisome proliferator-activated receptor- coactivator-1α expression was also associated with a net loss of mitochondrial protein and oxidative capacity. Reduced mitochondrial number was associated with a downregulation of transcription factor A, mitochondrial, and other genes required for mitochondrial biogenesis. Electron microscopy demonstrated that, in right ventricular failure tissue, mitochondria had abnormal shape and size. Lastly, respirometric analysis demonstrated that mitochondria isolated from right ventricular failure tissue had a significantly reduced ADP- stimulated (state 3) rate for complex I. Conversely, functional right ventricular hypertrophy in the pulmonary artery banding model showed normal expression of peroxisome proliferator-activated receptor- coactivator-1α, whereas the expression of fatty acid oxidation genes was either preserved or unregulated. Moreover, pulmonary artery banding-right ventricular tissue exhibited preserved transcription factor A mitochondrial expression and mitochondrial respiration despite elevated right ventricular pressure-overload. We conclude that right ventricular dysfunction, but not functional right ventricular hypertrophy in rats, demonstrates a gene expression profile compatible with a multilevel impairment of fatty acid metabolism and significant mitochondrial dysfunction, partially independent of chronic pressure-overload.

La fatigue est un symptôme fréquent chez les patients atteints de sclérose en plaques (SEP). Malgré la gravité de ce symptôme, sa physiopathologie demeure vague et ses traitements sont insatisfaisants dans la majorité des cas. L’objectif de ce travail était de comprendre les mécanismes sous-jacents de la fatigue liée à la SEP, et tester les effets de la stimulation électrique transcrânienne (tDCS) sur ce symptôme. Dans une première étude (revue de littérature), on a analysé les données disponibles sur la physiopathologie de la fatigue dans la SEP, et on a identifié une boucle cortico-striato-thalamo-corticale associée à ce symptôme. On a trouvé que, sur le plan neuropsychologique, les symptômes affectifs sont les corrélats les plus pertinents. Cependant, les corrélats neurophysiologiques de ce symptôme sont peu étudiés et une discordance existe dans la littérature quant aux résultats rapportés par les divers travaux. Ensuite, dans une deuxième étude, on a effectué une évaluation physiopathologique de la fatigue chez 38 patients atteints de SEP. Les patients fatigués avaient, par rapport à ceux non fatigués, une symptomatologie affective plus prononcée, une inhibition intracorticale plus élevée et des anomalies cortico-sous-corticales touchant les noyaux caudés et le cortex pariétal. Les résultats neuropsychologiques de ce travail suggèrent des mécanismes sous-jacents communs ainsi que des relations bidirectionnelles entre la fatigue et les symptômes affectifs. Les résultats neurophysiologiques reflètent des processus de plasticité mal adaptative à l’origine de la fatigue. Les résultats radiologiques soutiennent la présence d’une boucle cortico-sous-corticale à la base de la perception de la fatigue dans la SEP. Dans une troisième étude, on s’est intéressé à étudier, chez 27 patients, la neurophysiologie des symptômes affectifs associés à la fatigue dans la SEP. Une association significative a été observée entre l'alexithymie et la période de silence corticale. Les résultats mettent en évidence la relation entre l'alexithymie et une transmission gabaergique défectueuse, et concordent avec des travaux antérieurs réalisés chez des sujets sains et des patients souffrant de troubles de la personnalité. Dans une quatrième étude, on a effectué une revue de la littérature sur la place de la tDCS dans le traitement de la fatigue de la SEP, et on a identifié quelques travaux qui ont rapporté des résultats prometteurs obtenus en réponse à une stimulation anodique des régions sensorimotrices. Ensuite, dans une cinquième étude, on a évalué la place de la tDCS anodique préfrontale gauche ou pariétale droite dans le traitement de la fatigue liée à la SEP. 10 patients fatigués atteints de SEP ont été inclus dans une étude croisée randomisée contrôlée en double aveugle (stimulation anodique réelle ou placebo ciblant le cortex préfrontal gauche ou pariétal droit). Seule la stimulation active préfrontale gauche s’est avérée efficace sur la fatigue. Enfin, du fait de la possibilité de prolonger et de potentialiser les effets en multipliant les séances de stimulation, on a appliqué dans une dernière étude, 14-19 séances de tDCS anodique préfrontale gauche chez deux patients ; cette intervention a permis de maintenir, sur plusieurs semaines, les effets bénéfiques de la tDCS sur la fatigue et améliorer d’autres mesures cognitives et affectives. Compte tenu du caractère handicapant de la SEP, des projets futurs pourraient tester l’application de la tDCS à domicile, avec un outil de stimulation bien sécurisé et un contrôle technique supervisé à distance afin de s’assurer du bon déroulement des séances et maximiser les bénéfices. Aussi, un couplage de la tDCS à des techniques de psychothérapie, notamment la thérapie cognitivo-comportementale, semble avoir une place dans l’arsenal thérapeutique de ce symptôme et mérite d’être évalué dans l’avenir proche<br>Fatigue is a common symptom that dramatically affects the quality of life of patients with multiple sclerosis (MS). Despite the severity of this symptom, its pathophysiology remains vague and diverse, and its available treatments are unsatisfactory in the majority of cases. The aim of this work was to understand the underlying mechanisms of fatigue in MS, and then to conduct a therapeutic study to assess the effects of transcranial direct current stimulation (tDCS) on fatigue in MS patients.In a first study (literature review), the available data on the pathophysiology of fatigue in MS were analyzed, and a cortico-striato-thalamo-cortical loop associated with this symptom was identified. Affective symptoms constitute the most pertinent neuropsychological correlates. Neurophysiological data are scarce and inconsistent across the studies. Then, in a second study, a multidisciplinary assessment of fatigue was performed in 38 MS patients. Compared to non-fatigued patients, fatigued ones had higher scores of affective symptoms; higher intracortical inhibition; and cortico-subcortical abnormalities (caudate nuclei and parietal cortex). The neuropsychological findings suggest common underlying mechanisms as well as bidirectional relationships between fatigue and affective symptoms. The neurophysiological findings may reflect maladaptive plasticity processes behind the generation of fatigue. The radiological findings support the existence of a cortico-subcortical loop at the basis of MS fatigue. In a third study, the neurophysiology of affective symptoms associated with MS fatigue was assessed in 27 patients. A significant association was found between alexithymia and the cortical silent period. These results highlight the relationship between alexithymia and defective GABAergic transmission and are consistent with previous work in healthy subjects and patients with personality disorders.In a fourth study, a literature review was conducted on the use of tDCS to treat MS fatigue, and a few studies targeting the sensorimotor regions, and yielding promising antifatigue effects were identified. In a fifth study, the place of anodal prefrontal or parietal tDCS in the treatment of fatigue was assessed in 10 fatigued MS patients in a crossover randomized controlled double-blind study (active or sham anodal tDCS over the left prefrontal or right parietal cortex). Only active left prefrontal stimulation improved fatigue. This work proposes tDCS as a potential therapeutic tool for treating MS fatigue. Finally, based on recent literature supporting the idea of a cumulative effect following the repetition of stimulation sessions, several sessions of left prefrontal anodal tDCS (14-19 sessions) were performed in two patients; this intervention led to a long-term improvement of fatigue as well as an amelioration of other cognitive and affective manifestations.Since MS is a debilitating disease, future projects could test the application of home-based tDCS using a well-secured stimulation setting and a remotely supervised technical control in order to ensure a successful session performance and maximize the clinical benefits. In addition, coupling tDCS with some psychotherapeutic approaches, notably the cognitive-behavioral therapy, could have a place in the therapeutic armamentarium of MS fatigue and merits in-depth assessment in the near future

This thesis discusses Slot antennas that are based in gap waveguide technology, which allows them to work with high frequency signals. It contains theoretical findings about antennas and waveguides, which are later used in the design. The practical section of this thesis concentrates on designing a specific gap waveguide for 10 and 24 GHz frequencies, starting with modeling and parameter optimalization. This gap waveguide is then used as a base for slot antenna design. The final antenna is designed for frequency of 10 GHz, for both linear and right-handed circular polarizations. With right-handed circular polarization, the achieved band was approximately 1.41 GHz, while the gain was 7,6 dB.

Nas circunstâncias atuais do cenário político brasileiro, a necessidade de mudanças na estrutura política se mostra premente. Assim, mais uma vez a sociedade brasileira está diante do tema Reforma Política. As modificações ocorridas nos últimos anos na estrutura política não contribuíram para o aprimoramento da representatividade no Congresso Nacional, tanto isso é verdade que o Brasil enfrenta uma grave crise de representatividade democrática. Houve, entretanto, mudanças pontuais, como a possibilidade da reeleição para os cargos do Poder Executivo, a necessidade de prestações de contas dos candidatos durante o processo eleitoral e ao final dele, uma maior transparência sobre os financiadores das campanhas eleitorais, prazos diferenciados de permanência mínima nos partidos políticos por parte daqueles que desejam concorrer a cargos eletivos. Após esse debate sobre a democracia, haverá um segundo momento onde será abordada a releitura da teoria da soberania popular realizada por Roberto Viciano Pastor e Rubén Martinez Dalmau conhecida como novo constitucionalismo latino-americano. Para tanto, serão utilizadas, como subsídio, as experiências de mudanças constitucionais ocorridas no Equador, Venezuela e Bolívia, a fim de demonstrar como um processo de reforma política consistente pode favorecer o processo de consolidação da democracia no Brasil. O debate social surgido após as eleições de 2014, conhecidas perante a Justiça Eleitoral como Eleições Gerais (Presidente da República, Governador de Estado, Senadores, Deputados Federais, Estaduais e Distritais), não apresentou ainda o resultado esperado pelo Brasil, qual seja, a tentativa de moralização das campanhas eleitorais e da gestão política como um todo. Escândalos de corrupção, principalmente sobre o financiamento privado por meio de doações às campanhas eleitorais, foram o verdadeiro motor para movimentar uma engrenagem obsoleta encontrada no Congresso Nacional. Os diversos projetos de lei, bem como as diversas propostas de emenda à Constituição tratavam exclusivamente de pontos oriundos do Direito Eleitoral, a exemplo do voto distrital e suas diversas ramificações e compreensões jurídicas, financiamento das campanhas eleitorais, voto proporcional e possibilidade de reeleição para os chefes do Poder Executivo. E, dentro dessa perspectiva, um terceiro capítulo abordará a reforma política em trâmite no Congresso Nacional, por meio da Comissão Especial criada para debater esse tema, bem como a proposta de emenda à Constituição Federal que servirá de norte para as futuras modificações constitucionais e legislativas. Ter-se-á, nas considerações finais, o resultado das pesquisas empreendidas sobre o texto base utilizado na referida comissão, a PEC n 113/2015 da Câmara Federal e suas consequências, caso seja aprovada da maneira como se encontra redigida.<br>In Brazils current political scenario, there is a pressing need for change in political structure. Thus, once more Brazilian society faces the topic of Political Reform. The alterations that happened during the past few years in the countrys political structure did not contribute towards improving representation in National Congress; such reality causes Brazil to face a serious crisis in democratic representation. There were, however, specific alterations, such as the possibility of reelection for Executive seats; the need for legal accountability reports for candidates undergoing electoral process, and at its end, greater transparency regarding electoral campaign financers; different time of affiliation in political party requirements for those intending to run for office. After this debate on democracy, there will be a moment where a reinterpretation on the theory of popular sovereignty made by Roberto Viciano Pastor and Rubén Martinez Dalmau, known as Latin-America new constitutionalism, shall be addressed. To do so, the experiences on constitutional changes in Venezuela, Ecuador e Bolivia will be used as subsidy for demonstrating an alternative to political reform process. The social debate that surfaced after the 2014 elections, known to Electoral Justice as General Elections (Country President, State Governors, Senators, Federal, State and Federal District Congressmen), did not yet show any of the results Brazil expected, such as the attempt to moralize political campaigns and political management as a whole. Corruption scandals, especially regarding private funding through donations to electoral campaigns, were the real engine powering obsolete gears found in National Congress. Many bills, as well as many Constitution amendment proposals dealt solely with points that came from Electoral Law, such as district voting and its many juridical understandings and ramifications, electoral campaign funding, proportional vote and the possibility of reelection for Executive leading seats. And, within this perspective, a third chapter will address the political reform currently being processed in National Congress, by means of the Special Committee created to discuss this topic, as well as the proposal of an amendment to the Federal Constitution which shall guide future constitutional and legislative modifications. By the end, there shall be, within final considerations, the results of research undertaken on the base text used in the aforementioned committee, PEC n. 113/2005 from Federal Congress, and its consequences in the event of it being approved the way it is currently written.

Made available in DSpace on 2017-06-01T18:18:35Z (GMT). No. of bitstreams: 1 jose_guerra_andrade_lima_neto.pdf: 527698 bytes, checksum: 56c7d2ea10979b90507eada0a6d4e83c (MD5) Previous issue date: 2016-03-31<br>In Brazil s current political scenario, there is a pressing need for change in political structure. Thus, once more Brazilian society faces the topic of Political Reform. The alterations that happened during the past few years in the country s political structure did not contribute towards improving representation in National Congress; such reality causes Brazil to face a serious crisis in democratic representation. There were, however, specific alterations, such as the possibility of reelection for Executive seats; the need for legal accountability reports for candidates undergoing electoral process, and at its end, greater transparency regarding electoral campaign financers; different time of affiliation in political party requirements for those intending to run for office. After this debate on democracy, there will be a moment where a reinterpretation on the theory of popular sovereignty made by Roberto Viciano Pastor and Rubén Martinez Dalmau, known as Latin-America new constitutionalism, shall be addressed. To do so, the experiences on constitutional changes in Venezuela, Ecuador e Bolivia will be used as subsidy for demonstrating an alternative to political reform process. The social debate that surfaced after the 2014 elections, known to Electoral Justice as General Elections (Country President, State Governors, Senators, Federal, State and Federal District Congressmen), did not yet show any of the results Brazil expected, such as the attempt to moralize political campaigns and political management as a whole. Corruption scandals, especially regarding private funding through donations to electoral campaigns, were the real engine powering obsolete gears found in National Congress. Many bills, as well as many Constitution amendment proposals dealt solely with points that came from Electoral Law, such as district voting and its many juridical understandings and ramifications, electoral campaign funding, proportional vote and the possibility of reelection for Executive leading seats. And, within this perspective, a third chapter will address the political reform currently being processed in National Congress, by means of the Special Committee created to discuss this topic, as well as the proposal of an amendment to the Federal Constitution which shall guide future constitutional and legislative modifications. By the end, there shall be, within final considerations, the results of research undertaken on the base text used in the aforementioned committee, PEC n. 113/2005 from Federal Congress, and its consequences in the event of it being approved the way it is currently written.<br>Nas circunstâncias atuais do cenário político brasileiro, a necessidade de mudanças na estrutura política se mostra premente. Assim, mais uma vez a sociedade brasileira está diante do tema Reforma Política. As modificações ocorridas nos últimos anos na estrutura política não contribuíram para o aprimoramento da representatividade no Congresso Nacional, tanto isso é verdade que o Brasil enfrenta uma grave crise de representatividade democrática. Houve, entretanto, mudanças pontuais, como a possibilidade da reeleição para os cargos do Poder Executivo, a necessidade de prestações de contas dos candidatos durante o processo eleitoral e ao final dele, uma maior transparência sobre os financiadores das campanhas eleitorais, prazos diferenciados de permanência mínima nos partidos políticos por parte daqueles que desejam concorrer a cargos eletivos. Após esse debate sobre a democracia, haverá um segundo momento onde será abordada a releitura da teoria da soberania popular realizada por Roberto Viciano Pastor e Rubén Martinez Dalmau conhecida como novo constitucionalismo latino-americano. Para tanto, serão utilizadas, como subsídio, as experiências de mudanças constitucionais ocorridas no Equador, Venezuela e Bolívia, a fim de demonstrar como um processo de reforma política consistente pode favorecer o processo de consolidação da democracia no Brasil. O debate social surgido após as eleições de 2014, conhecidas perante a Justiça Eleitoral como Eleições Gerais (Presidente da República, Governador de Estado, Senadores, Deputados Federais, Estaduais e Distritais), não apresentou ainda o resultado esperado pelo Brasil, qual seja, a tentativa de moralização das campanhas eleitorais e da gestão política como um todo. Escândalos de corrupção, principalmente sobre o financiamento privado por meio de doações às campanhas eleitorais, foram o verdadeiro motor para movimentar uma engrenagem obsoleta encontrada no Congresso Nacional. Os diversos projetos de lei, bem como as diversas propostas de emenda à Constituição tratavam exclusivamente de pontos oriundos do Direito Eleitoral, a exemplo do voto distrital e suas diversas ramificações e compreensões jurídicas, financiamento das campanhas eleitorais, voto proporcional e possibilidade de reeleição para os chefes do Poder Executivo. E, dentro dessa perspectiva, um terceiro capítulo abordará a reforma política em trâmite no Congresso Nacional, por meio da Comissão Especial criada para debater esse tema, bem como a proposta de emenda à Constituição Federal que servirá de norte para as futuras modificações constitucionais e legislativas. Ter-se-á, nas considerações finais, o resultado das pesquisas empreendidas sobre o texto base utilizado na referida comissão, a PEC nº 113/2015 da Câmara Federal e suas consequências, caso seja aprovada da maneira como se encontra redigida.

Conselho Nacional de Desenvolvimento Científico e Tecnológico<br>O PLC 122/2006 configurou um projeto de lei que visava criminalizar atos de preconceito e discriminação motivados por gênero, sexo, orientação sexual, identidade de gênero, idade e deficiência humana, alterando a Lei n 7.716, de 5 de janeiro de 1989, que criminaliza o preconceito motivado por raça, cor, etnia, religião ou procedência nacional. Desde perspectivas teológicas, a dissertação apresenta o PLC 122 a partir do seu nascedouro na Câmara dos Deputados em 2001, até a culminância do apensamento do PLC 122/2006 ao Projeto de Lei do Senado que intenta a reforma do Código Penal (PLS 236/2012) em 2013. No primeiro capítulo, foram elencados dados estatísticos e conceituais sobre a homofobia, programas governamentais que buscam a erradicação da homofobia no Brasil e no mundo, bem como uma contextualização histórica do PLC 122/2006. No segundo capítulo, elaborou-se um levantamento discursivo em torno da posição de grupos religiosos que se revelaram contrários ao PLC 122/2006, a saber, a Bancada Evangélica, a Conferência Nacional dos Bispos do Brasil (CNBB) e a Associação Brasileira de Instituições Educacionais Evangélicas (ABIEE). Essas vozes rebateram o PLC 122/2006 com argumentos que giraram em torno de uma possível restrição da liberdade religiosa caso o PLC fosse aprovado, o que gerou um conflito de direitos entre as partes que lutavam pró ou contra o projeto. A seguir, ilustrou-se o estudo com um breve levantamento acerca do discurso oficial e posicionamentos de outras vozes religiosas (sobretudo protestantes) que têm se pronunciando frente ao tema. No terceiro capítulo, abordou-se de que forma o embate exposto conversa com o estabelecimento da laicidade do Estado e a construção dos direitos humanos, identificando um conflito de direitos gerado a partir da denúncia de que a intervenção de vozes religiosas na política e na implementação das políticas públicas fere a noção de Estado laico. Em contrapartida, para os evangélicos, grupo que explicitamente se ergue em defesa da "moral cristã e da família normativa de um país de maioria cristã, esse rechaço fere, igualmente, a democracia e a constituição brasileira (1988), que assegura a todo/a cidadão/ã a liberdade religiosa e de expressão. Em direito outorgado pela constituição e em missão evocada pela confissão de fé cristã que ensina a defender a vida em sua diversidade acima de qualquer lei ou dogma, outras vozes eclesiais, a(s) teologia(s) pública(s) cristã(s) e as entidades ecumênicas são participantes públicas a contribuir para com o debate e a luta por direitos humanos das pessoas LGBT. Ao fim e ao cabo, defende-se o contínuo diálogo sobre a urgência em criminalizar a homofobia no Brasil, assumindo que a labuta é árdua, conflituosa e até dolorosa, mas o silêncio que oprime precisa ser quebrado e denunciado diariamente pela sociedade civil, pelas igrejas (em sua diversidade), teologias públicas e entidades ecumênicas e, não por último, pelos/as representantes do povo no Congresso Nacional para uma construção humana dos direitos humanos LGBT.<br>PLC 122/2006 was a bill aimed at criminalizing acts of prejudice and discrimination motivated by gender, sex, sexual orientation, gender identity, age and human disability, amending Law No. 7.716, of January 5, 1989, which criminalizes bias motivated by race, color, ethnicity, religion or national origin. From theological perspectives, the dissertation presents the bill from its emergence in the House of Representatives in 2001, to the culmination of the attachment of PLC 122/2006 to PLS 236/2012 in 2013 (a Senate bill that intends to amend the Penal Code). In the first chapter, we have provided conceptual and statistical data on homophobia, listed government programs that seek to eradicate homophobia in Brazil and in the world, and offered a historical overview of PLC 122/2006. In the second chapter, we have elaborated a discursive survey on the position of religious groups that were contrary to PLC 122/2006, namely evangelicals and Roman Catholics. These voices countered PLC 122/2006 with arguments that revolved around a possible restriction of religious freedom if the bill were approved, which created a conflict of rights between the parties that fought for or against it. Next, the study has been illustrated with a brief survey about the official discourse and positions of other religious voices (specifically the Protestant) that have been debating the issue. In the third chapter, we have addressed the question on how this clash relates to the establishment of the Secular State and the construction of human rights, identifying a conflict of rights generated from the complaint that the intervention of religious voices in politics and in the implementation of public policy injures the concept of Secular State. In contrast, for the evangelicals, a group that explicitly stands in defense of a "Christian morality" and a normative family" of a country with a Christian majority, this rejection also injures democracy and the Brazilian Constitution of 1988, which ensures all the citizen religious freedom and expression. As a right granted by the constitution and a mission evoked by the Christian confession of faith that teaches to uphold life in its diversity above any law or dogma, other church voices, Christian public theologies and ecumenical entities are called to contribute to the debate and the struggle for the human rights of LGBT people. After all, we advocate the ongoing dialogue on the urgent need to criminalize homophobia in Brazil assuming that the work is hard, conflicted and even painful, but the silence that oppresses needs to be broken and reported daily by civil society, churches (in their diversity), public theologies and ecumenical bodies, and, not least, by the representatives of people in Congress for a human construction of human rights of LGBT people.

Dans un premier temps, nous avons observé la chronologie des altérations de la biogenèse et de la fonction mitochondriale dans les ventricules droit (VD) et gauche (VG) et le muscle gastrocnémien (GAS) dans un modèle animal d'hypertension artérielle pulmonaire (HTAP). Nous avons constaté une diminution précoce des facteurs impliqués dans la biogénèse mitochondriale du GAS. Plus tard, les mêmes anomalies apparaissaient dans le VD. Au stade décompensé de l'insuffisance cardiaque droite s'ajoutaient une diminution de la protéine PGC-1 , de l'activité de la citrate-synthase et de la respiration mitochondriale. L'expression des ARNm et la respiration mitochondriale du VG n'étaient pas modifiées de façon significative.Dans un deuxième temps, nous avons étudié l'effet de l'entraînement en mode excentrique sur le même modèle d'HTAP. La survie des rats entraînés n'était pas différente de celle des rats sédentaires et la tolérance hémodynamique évaluée par échocardiographie et cathétérisme cardiaque a été bonne. Le bénéfice de l'entraînement s'est traduit par une augmentation de la vitesse maximale de course dans les deux groupes entraînés, malades et témoins.

Abstract The focus of this thesis is to study direction of arrival (DoA) estimation algorithms for reconfigurable leaky-wave antennas and advanced antenna arrays. Directional antennas can greatly improve the spectrum reuse, interference avoidance, and object and people localization. DoA estimation algorithms have also been shown to be useful for applications such as positioning for user tracking and location-based services in wireless local area networks (WLANs). The main goal is to develop novel DoA estimation algorithms for both advanced antenna arrays and composite right/left-handed (CRLH) leaky-wave antennas (LWAs). The thesis introduces novel modifications to existing DoA estimation algorithms and shows how these can be modified for real-time DoA estimation using both antenna types. Three modified DoA estimation algorithms for CRLH-LWAs are presented: 1) modified multiple signal classification (MUSIC), 2) power pattern cross-correlation (PPCC), and 3) adjacent power pattern ratio (APPR). Additionally, the APPR algorithm is also applied to advanced antenna arrays. The thesis also presents improvements to the modified MUSIC and APPR algorithms. The complexity of the algorithms is reduced by selecting a smaller number of received signals from different directions. The results show that the selection of the radiation patterns is very important and that the proposed algorithms can successfully estimate the DoA, even in a real-world environment. Based on the results, this thesis provides a good starting point for future research of DoA estimation algorithms to enhance the performance of future-generation wireless networks and the accuracy of localization<br>Tiivistelmä Tässä väitöskirjassa tutkitaan suunnanestimointialgoritmeja uudelleen konfiguroituville vuotoaaltoantenneille (LWA, leaky wave antenna) ja kehittyneille antenniryhmille. Suuntaavilla antenneilla voidaan parantaa huomattavasti spektrin uudelleen käyttöä ja esineiden ja ihmisten sijaintipaikannusta sekä pienentää häiriöitä. Suunnanestimointialgoritmit ovat myös osoittautuneet hyödylliseksi esimerkiksi seuranta- ja sijaintipaikannuspalvelusovelluksille langattomissa lähiverkoissa. Työn päätavoite on kehittää uusia suunnanestimointialgoritmeja sekä kehittyneille antenniryhmille että vuotoaaltoantenneille (composite right/left-handed (CRLH) LWA). Työssä osoitetaan, miten olemassa olevia suunnanestimointialgoritmeja voidaan muokata uudella tavalla, jotta ne soveltuisivat molemmille antennityypeille reaaliaikaiseen suunnanestimointiin. Vuotoaaltoantennille on kehitetty kolme erilaista suunnanestimointialgoritmia: 1) muunneltu MUSIC- (multiple signal classification), 2) säteilykyvioiden tehojen ristikorrelaatio- (PPCC, power pattern cross correlation) ja 3) vierekkäisten säteilykuvioiden tehosuhdealgoritmi (APPR, adjacent power pattern ratio). APPR-algoritmia on myös käytetty kehittyneelle antenniryhmälle. Työssä esitetään myös parannuksia muunnelluille MUSIC- ja APPR-algoritmeille. Algoritmien kompleksisuutta voidaan pienentää valitsemalla vähemmän vastaanotettuja signaaleja. Tulokset osoittavat, että signaalien valinta on hyvin tärkeää ja ehdotetut algoritmit estimoivat onnistuneesti saapuvan signaalin suunnan todellisessa mittausympäristössä. Yhteenvetona voidaan sanoa, että tämä väitöstyö on hyvä lähtökohta suunnanestimointialgoritmitutkimukselle, jonka tavoitteena on parantaa tulevien sukupolvien langattomien verkkojen suorituskykyä ja paikannuksen tarkkuutta

Abstract Neuropsychiatric illnesses usually become overtly manifest in adolescence and early adulthood. A critical long-term aim is to be able to prevent the development of such illnesses, which requires instruments to identify subjects at high risk of illness and to offer them effective interventions. There is an indisputable need for more sophisticated methods to enable more precise detection of adolescents and young adults who are at high risk of developing psychosis. Abnormal function in brain networks has been reported in people with schizophrenia and other psychotic disorders. Similar abnormalities have been found also in people at risk for developing psychosis, but it is not known whether this applies also to spontaneous resting state activity in young people with a familial risk for psychosis. We conducted resting-state functional MRI (R-fMRI) in 72 (29 male) young adults with a history of psychosis in one or both parents (FR) but without psychosis themselves, and 72 (29 male) similarly healthy control subjects without familial risk for psychosis. Both groups in the Oulu Brain and Mind study were drawn from the Northern Finland Birth Cohort 1986. All volunteers were 20–25 years old. Parental psychosis was established using the Care Register for Health Care. R-fMRI data was pre-processed using independent component analysis (ICA). A dual regression technique was used to detect between-group differences with p &lt; 0.05 threshold corrected for multiple comparisons at voxel level. FR subjects demonstrated significantly decreased activity compared to control subjects in the default mode network and in the central executive network and increased activity in the cerebellum. The findings clarify previously controversial literature on the subject. The finding suggests that abnormal activity in these brain networks in rest may be associated with increased vulnerability to psychosis. The findings maybe helpful in developing more precise methods for detecting young people at highest risk for developing psychosis<br>Tiivistelmä Psykoottisiin häiriöihin sairastutaan yleensä nuoruudessa tai varhaisaikuisuudessa. Psykoositutkimuksen tavoitteena on löytää uusia menetelmiä, joiden avulla kyettäisiin tunnistamaan suurimmassa psykoosiriskissä olevat nuoret, jotta heille voitaisiin tarjota sairautta ennaltaehkäiseviä hoitokeinoja. Skitsofreniaan ja muihin psykoottisiin häiriöihin sairastuneilla on havaittu aivotoiminnan poikkeavuuksia. Samankaltaisia aivotoiminnan poikkeavuuksia on havaittu myös nuorilla, jotka ovat vaarassa sairastua psykoosiin. Toistaiseksi on ollut epäselvää, onko psykoosiin sairastuneiden henkilöiden lapsilla aivohermoverkkojen toiminnan poikkeavuuksia lepotilassa. Suoritimme aivojen lepotilan MRI-tutkimuksen (R-fMRI) 72:lle (29 miestä) nuorelle aikuiselle, joiden jompikumpi vanhempi oli sairastunut psykoosin sekä 72:lle (29 miestä) nuorelle aikuiselle, joiden vanhemmat eivät olleet sairastaneet psykoosia. Molemmat tutkimusryhmät tässä Oulu Brain and Mind -tutkimuksessa olivat Pohjois-Suomen 1986 syntymäkohortin jäseniä. Tutkittavat olivat 20–25 vuoden iässä. Lepotilan toiminnallinen magneettikuvaus suoritettiin 1.5 Teslan Siemensin magneettikuvantamislaitteella. Tutkimuskohteiksi valittiin lepotilan toiminnallinen aivohermoverkko, toiminnan ohjauksesta vastaava aivohermoverkko ja pikkuaivot. Kuvantamisdataan sovellettiin itsenäisten komponenttien analyysia aivohermoverkkojen määrittämistä varten. Ryhmien välisen eron havaitsemiseen käytettiin ei-parametristä permutaatiotestiä, joka kynnystettiin tilastollisesti merkitsevään tasoon (p &lt; 0.05). Lepotilan oletushermoverkossa ja toiminnanohjauksesta vastaavassa aivohermoverkoissa havaittiin vähäisempää aktiivisuutta ja pikkuaivoissa kohonnutta aktiivisuutta perinnöllisessä psykoosiriskissä olevilla nuorilla aikuisilla verrattuna verrokkeihin. Tutkimustulokset selkeyttivät aiempaa ristiriitaista kirjallisuutta tutkimusaiheesta. Tutkimuksessa havaittujen aivoalueiden poikkeava toiminta lepotilassa voi liittyä kohonneeseen psykoosin puhkeamisriskiin. Tutkimuslöydösten avulla voidaan todennäköisesti edesauttaa parempien kuvantamismenetelmien kehittämistä suurimmassa psykoosiriskissä olevien nuorten tunnistamiseen

Submitted by Leandro Silva (leandro.buenavila@gmail.com) on 2016-12-22T11:42:56Z No. of bitstreams: 1 dissertacao_leandrosilva.pdf: 1508186 bytes, checksum: d14f17c817d0ebaa8881d51690a3d8e8 (MD5)<br>Approved for entry into archive by ÁUREA CORRÊA DA FONSECA CORRÊA DA FONSECA (aurea.fonseca@fgv.br) on 2017-01-03T13:50:05Z (GMT) No. of bitstreams: 1 dissertacao_leandrosilva.pdf: 1508186 bytes, checksum: d14f17c817d0ebaa8881d51690a3d8e8 (MD5)<br>Made available in DSpace on 2017-01-18T12:16:36Z (GMT). No. of bitstreams: 1 dissertacao_leandrosilva.pdf: 1508186 bytes, checksum: d14f17c817d0ebaa8881d51690a3d8e8 (MD5) Previous issue date: 2016-11-29<br>Este trabalho constitui-se de uma análise e uma proposta de intervenção sobre a transparência das informações sobre as políticas públicas propostas pelo Governo do Estado do Rio de Janeiro. Entende-se como essas informações, aquelas relativas a elaboração e execução dos bens e serviços entregues à sociedade, e que constam no Plano Plurianual (PPA). Historicamente, o Rio de Janeiro possui uma administração centralizada com fortes traços patrimonialistas, fraca tradição em planejamento e grande restrição ao acesso à informação. Tendo essas questões como pano de fundo, decorrem algumas inconsistências visíveis tanto em nível estratégico de governo quanto em nível mais específico no âmbito dos órgãos da administração pública fluminense, cuja análise foi realizada sob três dimensões: física, intelectual e comunicacional. Disto, propõe-se o desafio de contribuir para a transparência das informações sobre políticas públicas, a partir das determinações constantes nas normas vigentes sobre transparênca, dos estudos já realizados sobre o tema, das boas práticas no setor público e das inconsistências encontradas no governo fluminense. Dessas análises, foram propostas ações e recomendações para melhoria, e elencados os benefícios esperados decorrentes dessa intervenção.<br>This paper consists of an analysis and a proposal for intervention on the transparency of information of public policies proposed by the state government of Rio de Janeiro. It´s understood as such information, those related to development and implementation of products and services delivered to society, included in the Plano Plurianual (PPA), a four year long-term plan. Historically, Rio de Janeiro has a centralized administration with strong patrimonial traits, weak tradition in planning and serious restriction on access to information. Having these issues as a backdrop, there´s some inconsistencies visible both at the strategic and specific level of the Rio de Janeiro government, whose analysis was performed in three dimensions: physical, intellectual, and communicational. From this analisys, comes the challenge to contribute to improve the transparency of information of public policies, consider studies and determinations in the current regulations on transparency, good practices in the public sector and inconsistencies detected in the Rio de Janeiro state government. Finally, the paper suggest actions and recommendations for improving transparency and list the expected benefits resulting from such intervention.

La notion d’universalité se présente sous l’angle d’une distinction entre l’universalité de droit et l’universalité de fait. Cette opposition, héritage de la tradition, a été, en droit moderne, coulée dans des objets juridiques nouveaux. L’universalité de droit, assimilée à la notion de patrimoine, s’identifie grâce à l’idée de corrélation actif/passif ; l’universalité de fait à l’idée de collection de biens qui se réifie. Devenue familière, cette distinction souffre de quelques paradoxes qui compliquent son insertion dans le droit civil. Contrairement à l’idée affirmée en doctrine, la corrélation actif/passif n’est pas le seul élément d’identité de l’universalité de droit. Comprise, en droit moderne, à partir de la théorie du patrimoine d’Aubry et Rau, elle se différencie également de l’idée de bien. Toutefois, le législateur contemporain, à travers les mécanismes de l’EIRL et de la Fiducie, a consacré l’idée d’une universalité cessible, donc objet de droit.La convergence des deux formes d’universalités vers l’idée de choses appropriées justifie de revenir sur la théorie des universalités et d’interroger le bienfondé de cette distinction. De cette analyse, il ressort que le siège réel de l’universalité correspond à l’idée d’ensemble de biens, qui se réifie. Ce résultat est rendu possible grâce à la communauté d’affectation déterminée par le propriétaire des biens. Il va, par ce fait, créer une interdépendance fonctionnelle entre les différents biens.La structure de l’universalité rend délicate l’appréhension de son régime. Toutefois, sa qualification de bien permet de constater qu’elle s’insère facilement dans la théorie générale des biens, même si quelques ajustements sont nécessaires du fait de son caractère universel. C’est tout un pan du droit des biens qui se trouve saisi par une conception monolithique de l’universalité<br>In French law, the issue of universitas is usually approached from the universitas juris versus universitas rerum perspective. Universitas juris is the totality of the rights and liabilities of a person regarding its asset; by contrast, universitas rerum is understood as a totality of objects treated in one or more respects as a whole in law. However, in modern law, this traditional dichotomy merged into new subject-matters.Indeed, through the mechanisms such as “Individual Enterprises of Limited Responsibility” and “Trust”, French legislation dedicated, as a new subject-matter, the concept of “transferable” universitas. As a consequence, contrary to the prevailing doctrine, the interrelationship between asset and liability appears not to be the only element of identification of universitas juris. Based on that observation, the commonly enforced distinction between universitas juris and universitas rerum raises legal paradoxes and reveals not to be fit to the modern french civil law.The convergence of the two forms of universitas emphasizes the relevance of the “theory of universitas” while questioning the merits of such dualism. It thus appears that the focal point of universitas must be located in the notion of “proprietary rights”. This is made possible through the upstream definition of a special-purpose asset by the owner, allowing a functional interdependence between different goods treated as an indivisible whole by the law.Concerning its regime, the universitas qualification as a “proprietary right” shows that it fits easily into “the general theory of property law”, even if some adjustments are necessary. It is an entire branch of property law grasped by a monolithic conception of universitas

This thesis examines the relation between Brazil's slavery past and the adoption of Constitutional Amendment Bill Nº 72, better known as "PEC das domésticas", which extended domestic workers' labor rights in Brazil. Being predominantly executed by black, poor women under precarious conditions, domestic work in Brazil is often portrayed as a continuation of relations of dominance and oppressional dynamics that have their origin in the country's colonial and slavery past. For a long time, domestic workers have been at the margins of Brazil's government policies and lacked proper legal protection and recognition, naturalizing their subaltern status as "second-class-citizen". Based on qualitative interviews with unionized domestic workers and representatives of the former government which passed the PEC in 2013, this work aims to analyze the role played by Brazil’s slavery legacy in the promotional process of the law. The thesis uses the concepts of intersectionality and the coloniality of power and gender to explore the core origin of domestic workers' enduring marginalization and discrimination. I argue that the debate about the living slavery legacy that domestic work carries played a significant double role in the PEC promotional process: on the one hand, the claim for the PEC involved the overarching objective to challenge persistent gender, class, and race asymmetries associated to the country's colonial and slavery past. On the other hand, the debate over the legacy of slavery was instrumentalized in the collective fight of domestic workers and their political allies to make their voices heard and push the law through.<br>Esta tese explora a relação entre o passado escravocrata do Brasil e a aprovação da Emenda Constitucional Nº 72, mais conhecida como "PEC das Domésticas", que ampliou os direitos laborais das trabalhadoras domésticas no país. Sendo predominantemente executado por mulheres negras e pobres em condições precárias, o trabalho doméstico no Brasil é frequentemente retratado como uma continuação das relações de poder e opressão cuja origem remonta ao passado colonial e escravocrata do país. Durante muito tempo, as domésticas estiveram à margem da política do Estado brasileiro e careciam de proteção e reconhecimento jurídico adequado, legitimando o seu estatuto subalterno de "cidadão de segunda classe". Com base em entrevistas qualitativas com domésticas sindicalizadas e representantes do governo na altura da aprovação da PEC em 2013, este trabalho visa analisar o papel do legado do passado escravocrata brasileiro na promoção da lei. A tese utiliza os conceitos de interseccionalidade e a colonialidade de poder e de género para explorar a origem da marginalização e discriminação permanente das domésticas. Defendo que o debate sobre o legado vivo da escravidão que o trabalho doméstico representa desempenhou um papel com duplo significado no processo promocional da PEC: por um lado, a reivindicação da PEC tinha como objectivo maior desafiar as assimetrias persistentes de género, classe e raça associadas ao passado colonial e escravocrata do país. Por outro lado, o debate sobre o legado da escravidão foi instrumentalizado na luta coletiva das domésticas e respetivos aliados políticos para forçar a aprovação da lei.

Dissertação de mestrado em Direitos Humanos<br>A presente dissertação tem por objetivo afirmar a dimensão jusfundamental do direito à proteção de dados pessoais no ordenamento jurídico brasileiro, perspectivando-o como o direito fundamental que efetivamente é. Apesar da ausência de consagração expressa neste sentido – algo que será brevemente ultrapassado por força de emenda constitucional em tramitação no Congresso Nacional (PEC n.º 17/2019) – o direito à proteção de dados pessoais possui inegável dimensão jusfundamental, sob pena da sua fragilização no confronto com outros direitos fundamentais. Nesta medida, analisaremos todo o percurso do direito à proteção de dados pessoais no ordenamento brasileiro, desde as primeiras formulações associadas à proteção da vida privada, até a atual iminência de reconhecimento formal pelo constituinte, procurando identificar o que distingue o direito à proteção de dados pessoais do direito à proteção da privacidade – ou seja, qual o seu âmbito de aplicação, o que protege, o que proíbe. Para tanto, foi adotada a metodologia indutiva, com base no estudo de fontes primárias (instrumentos normativos de âmbito internacional – tratados internacionais de proteção aos direitos humanos –, normas constitucionais, leis infraconstitucionais, jurisprudências) e fontes secundárias (doutrinas, artigos e trabalhos acadêmicos de autores brasileiros e estrangeiros). A dissertação está dividida em três capítulos. No primeiro capítulo será abordada a recepção dos direitos humanos no ordenamento jurídico brasileiro desde o direito à vida privada até o direito à proteção de dados pessoais. No segundo capítulo será apresentado o conceito de dados pessoais – inclusivamente no que tange aos dados de caráter sensível e aos dados anônimos –, bem como a relevância dos mesmos para o mercado digital, salientando ainda a importância da regulamentação do direito à proteção de dados pessoais em decorrência da sua dimensão jusfundamental. No terceiro capítulo será demonstrado como encontra-se disposto o direito à proteção de dados pessoais no ordenamento jurídico brasileiro, desde a Constituição da República Federativa do Brasil (CRFB) de 1988 até a Lei Geral de Proteção de Dados Pessoais (LGPD). Por fim, no capitulo final, será apresentado os impactos do COVID-19 sobre a LGPD, com ênfase final na Proposta de Emenda à Constituição (PEC) n.º 17/2019 e a decisão inédita do STF em discussão do Direito Fundamental à Proteção de Dados Pessoais.<br>This dissertation aims to affirm the fundamental dimension of the right to protection of personal data in the Brazilian legal system, viewing it as the fundamental right that it effectively is. Despite the absence of express consecration in this sense – something that will soon be overcome due to a constitutional amendment pending in the National Congress (PEC n.º 17/2019) – the right to the protection of personal data has an undeniable jusfundamental dimension, under penalty of its fragility in the confrontation with other fundamental rights. To this extent, we will analyze the entire path of the right to protection of personal data in the Brazilian system, from the first formulations associated with the protection of private life, to the current imminence of formal recognition by the constituent, seeking to identify what distinguishes the right to data protection. personal rights to the protection of privacy – that is, what is its scope, what protects, what it prohibits. For that, the inductive methodology was adopted, based on the study of primary sources (normative instruments of international scope – international treaties for the protection of human rights –, constitutional norms, infraconstitutional laws, jurisprudence) and secondary sources (doctrines, articles and academic works Brazilian and foreign authors). The dissertation is divided into three chapters. The first chapter will address the reception of human rights in the Brazilian legal system, from the right to private life to the right to the protection of personal data. In the second chapter, the concept of personal data will be presented – including with regard to sensitive data and anonymous data -, as well as their relevance to the digital market, also emphasizing the importance of regulating the right to protection of personal data. due to its fundamental dimension. In the third chapter, it will be demonstrated how the right to protection of personal data is provided for in the Brazilian legal system, from the Constitution of the Federative Republic of Brazil (CRFB) of 1988 to the General Law of Protection of Personal Data (LGPD). Finally, in the final chapter, the impacts of COVID-19 on the LGPD will be presented, with final emphasis on the Proposed Amendment to the Constitution (PEC) n.º 17/2019 and the unprecedented decision of the STF in discussion of the Fundamental Right to Protection Personal Data.