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Littérature scientifique sur le sujet « Resistance-to-time »

Auteur : Grafiati

Publié le 9 mars 2023

Mis à jour le 10 mars 2023

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Articles de revues sur le sujet "Resistance-to-time"

The Lancet. « Time to contain artemisinin resistance ». Lancet 383, n^o 9927 (avril 2014) : 1438. http://dx.doi.org/10.1016/s0140-6736(14)60700-5.

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Woods, Anne. « Antibiotic resistance : Time to fight back ». Dimensions of Critical Care Nursing 20, n^o 3 (mai 2001) : 56. http://dx.doi.org/10.1097/00003465-200105000-00014.

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Howarth, Frank, et David Poulter. « Vancomycin resistance : time to ban avoparcin ? » Lancet 347, n^o 9007 (avril 1996) : 1047. http://dx.doi.org/10.1016/s0140-6736(96)90187-7.

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Munro, Rob. « Antimicrobial resistance - time to start spending ». Prescriber 28, n^o 1 (janvier 2017) : 4. http://dx.doi.org/10.1002/psb.1527.

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Stebbing, Justin, et Tim Crook. « Cytotoxic-free treatment designs : time to resistance ». Nature Clinical Practice Oncology 4, n^o 1 (janvier 2007) : 1. http://dx.doi.org/10.1038/ncponc0695.

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Babkin, Sergey, et Anna Epishkina. « One-Time Passwords : Resistance to Masquerade Attack ». Procedia Computer Science 145 (2018) : 199–203. http://dx.doi.org/10.1016/j.procs.2018.11.040.

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Liu, Yong-Biao, Bruce E. Tabashnik, Timothy J. Dennehy, Amanda L. Patin et Alan C. Bartlett. « Development time and resistance to Bt crops ». Nature 400, n^o 6744 (août 1999) : 519. http://dx.doi.org/10.1038/22919.

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Yerly, Sabine, et Alexandra Calmy. « Time to overcome pretreatment HIV drug resistance ». Lancet Infectious Diseases 18, n^o 3 (mars 2018) : 239–40. http://dx.doi.org/10.1016/s1473-3099(17)30709-0.

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Swartz, Bradford L. « Resistance of Voice Onset Time Variability to Intoxication ». Perceptual and Motor Skills 75, n^o 2 (octobre 1992) : 415–24. http://dx.doi.org/10.2466/pms.1992.75.2.415.

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Voice onset times of /d/ and /t/ were measured for 16 adult subjects (age range 21 to 26 years) under conditions of sobriety and intoxication. Subjects consumed beer to reach intoxication levels between 0.075 and 0.100% as measured using a portable breathalyzer test. Analysis indicated consistent variabilities over time for each subject and resistance of VOT variability to alcohol influence.

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The Lancet. « Antimicrobial resistance : time to repurpose the Global Fund ». Lancet 399, n^o 10322 (janvier 2022) : 335. http://dx.doi.org/10.1016/s0140-6736(22)00091-5.

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Thèses sur le sujet "Resistance-to-time"

Ouyang, Quinglin. « Time to purchase your ownhouse : The resistance of housing investments againstmacroeconomic shocks ». Thesis, KTH, Fastigheter och byggande, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-277084.

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Housing is both a durable good and an investment vehicle, which makes it importantin people’s daily life aswell as for a nation’s economy. This thesis innovatively applies the Sharpe ratio on evaluating the performance of the US residentialhousing market within the time period from 2005:Q1 to 2019:Q3, andinvestigates how this performance would react upon macroeconomic shocks,including sudden changes in GDP growth rate and personal income growthrate, by establishing a vector auto-regression model with the lag order of four.The main results are that: (1)in the long run, direct residential investments are not significantly more profitable than treasury bills but not disappointing compared to the market portfolio of Dow Jones Industrial Average; (2)the performance of residential investments seem to slightly and positively co-move withGDP and personal income growth rate; (3)the long-term impacts that sudden GDP and personal income growths have on the performance seem inconspicuous and tend to mitigate within about three years and (4) limited evidence supports the hypothesis that current housing market performance can help predictfuture GDP growth rate. Based on housing’s two purpose of consumption andinvestment and the empirical results showing that direct investments on residentialproperties have similar risk-adjusted return level to short-term treasurybills, I suggest that financially feasible households purchase their own houseinstead of renting for a long time, and that speculative investors avoid puttingmoney in residential properties unless they have access to inside information.
Bostäder kan betraktas både som en hållbar vara och som ett investeringsinstrument.De är essentiella för människors vardag och har en viktig roll förett lands ekonomi. Denna avhandling använder innovativt Sharpe-förhållandet för att utvärdera hur den amerikanska bostadsmarknaden presterade under perioden2005: kvartal 1 till 2019: kvartal 3. Den försöker även undersöka om denna prestation påverkas av makroekonomiska chocker inklusive plötsligaförändringar i BNP-tillväxttakt och personliga inkomsttillväxthastighet. Detta görs genom att upprätta en vektor autoregression modell med en fördröjningsordningför fyra. De viktigaste resultaten är att: (1) på långsikt är direktabostadsinvesteringar inte betydligt mer lönsamma än statsskuldväxlar dock är det hellre inte en besvikelse jämfört med en marknadsportföljen av Dow JonesIndustrial Average; (2) Prestationen av bostadsinvesteringar verkar vara svagt och samverkar positivit både med BNP och tillväxttakten för personinkomst.(3) De långsiktiga effekterna av plötsliga tillväxter av BNP och personliga inkomster har på utvecklingen verkar vara vaga och tenderar att mildra inomcirka tre år och (4) begränsade bevis stöder hypotesen om att nuvarande bostadsmarknadsresultat kan bidra till att förutsäga framtida BNP-tillväxttakten.Baserat på bostädernas två syften inom konsumtion och investeringar, visar deempiriska resultaten att direkta investeringar i bostadsfastigheter har en liknande riskjusterad avkastningsnivå som kortfristiga statsskuldväxla. Därför föreslår jag att ekonomisk stabila hushåll borde köpa ett eget hus istället för att hyraunder en lång tid, och att spekulativa investerare borde undvika att satsa pengar inom bostadsfastigheter såvida de inte har tillgång till insider-information.

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Pipes, Candice L. « It's Time To Tell : Abuse, Resistance, and Recovery in Black Women's Literature ». The Ohio State University, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=osu1278001806.

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Arthur, Kimberly Ann. « Pentobarbital Sleep Time in Mouse Lines Selected for Resistance and Susceptibility to Fescue Toxicosis ». Thesis, Virginia Tech, 2002. http://hdl.handle.net/10919/9694.

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In previous work with mouse lines selected for resistance (R) and susceptibility (S) to fescue toxicosis, R mice had higher activities of Phase II liver enzymes glutathione S-transferase and uridine diphosphate glucuronosyl-transferase than S mice. Objectives of this study were: 1. to determine whether selection for toxicosis response had also caused divergence between lines in hepatic Phase I enzyme activity (as assessed by sleep time following sodium pentobarbital anesthesia), 2. to determine whether sleep time differences between lines were modulated by fescue toxins or enzyme inducers in the diet, and 3. to determine whether sleep time differences among individual mice were correlated with the impact of a toxin-containing diet on their post-weaning growth. In experiment 1, five dietary treatments were assigned to 24 male mice in each line: rodent food control, E+ (50% endophyte-infected fescue seed, 50% control), E+P (E+ with 1000 ppm phenobarbital), E- (50% endophyte-free fescue seed, 50% control), and E-P (E- with 1000 ppm phenobarbital). After four weeks on these diets, mice were challenged with a sleep time test. All mice were then switched to a pelleted rodent food diet. Each mouse then received a second sleep time test, a random 1/4 of the population after one, two, three, and four weeks on the standard diet. Results demonstrated that, regardless of dietary treatment, R mice had a shorter sleep time than S mice, suggesting higher activity of liver Phase I microsomal enzymes. Mice that were fed phenobarbital had significantly shorter sleep time than those whose diets did not include this microsomal enzyme inducer. Time interval between the first and second sleep time did not significantly impact the second sleep time, confirming line differences in the absence of toxins and inducers and with advancing age. In experiment 2, male and female R and S mice were fed an E- diet for 2 weeks, then an E+ diet for 2 weeks, followed by a pelleted rodent food diet for 2 weeks. Mice were then administered a sleep time test. Their growth rate response to fescue toxicosis was quantified as the proportional reduction in gain during two weeks on the E+ diet, compared to gain on E- during the previous two weeks. Sleep time was significantly influenced by line but not by sex or the line x sex interaction. As in Experiment 1, S mice slept longer than their R counterparts. The residual correlation between reduction in gain associated with the E+ diet and sleep time was only 0.04. Thus, under these experimental conditions an individual animal's Phase 1 enzyme activity did not predict how severely its growth rate would be depressed by a toxin-containing diet. Based upon these and previous studies, divergent selection for toxicosis response in mice was successful partially by causing divergence between lines both in Phase I and Phase II liver detoxification enzyme activities. If a heritable, practical, and economical criterion could be identified to quantify such differences in livestock species, then selection for toxicosis resistance might contribute to the solution of this important problem for American agriculture.
Master of Science

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Springer, Keith. « Exploring resistance to the placement of female graduates of Indiana Wesleyan University in full-time ministry positions in the Wesleyan Church ». Online full text .pdf document, available to Fuller patrons only, 2002. http://www.tren.com.

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Akiyama, Reiko. « Life History and Tolerance and Resistance against Herbivores in Natural Populations of Arabidopsis thaliana ». Doctoral thesis, Uppsala universitet, Växtekologi och evolution, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-159688.

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In this thesis, I combined observational studies with field and greenhouse experiments to examine selection on life history traits and variation in tolerance and resistance against herbivores in natural populations of the annual herb Arabidopsis thaliana in its native range. I investigated (1) phenotypic selection on flowering time and plant size, (2) the effects of timing of germination on plant fitness, (3) the effect of leaf damage on seed production, and (4) correlations between resistance against a specialist and a generalist insect herbivore. In all three study populations, flowering time was negatively related to plant fitness, but in only one of the populations, significant selection on flowering time was detected when controlling for size prior to the flowering season. The results show that correlations between flowering time and plant fecundity may be confounded by variation in plant size prior to the reproductive season. A field experiment detected conflicting selection on germination time: Early germination was associated with low seedling survival, but also with large leaf rosette before winter and high survival and fecundity among established plants. The results suggest that low survival among early germinating seeds is the main force opposing the evolution of earlier germination, and that the optimal timing of germination should vary in space and time as a function of the relative strength of selection acting during different life-history stages. Experimental leaf damage demonstrated that tolerance to damage was lowest among vegetative plants early in the season, and highest among flowering plants later in the season. Given similar damage levels, leaf herbivores feeding on plants before flowering should thus exert stronger selection on defence traits than those feeding on plants during flowering. Resistance against larval feeding by the specialist Plutella xylostella was negatively correlated with resistance against larval feeding by the generalist Mamestra brassicae and with resistance against oviposition by P. xylostella when variation in resistance was examined within and among two Swedish and two Italian A. thaliana populations. The results suggest that negative correlations between resistance against different herbivores and different life-history stages of herbivores may contribute to the maintenance of genetic variation in resistance.

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Harshman, D. K., B. M. Rao, J. E. McLain, G. S. Watts et J. Y. Yoon. « Innovative qPCR using interfacial effects to enable low threshold cycle detection and inhibition relief ». AAAS, 2015. http://hdl.handle.net/10150/621255.

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UA Open Access Publishing Fund
Molecular diagnostics offers quick access to information but fails to operate at a speed required for clinical decision-making. Our novel methodology, droplet-on-thermocouple silhouette real-time polymerase chain reaction (DOTS qPCR), uses interfacial effects for droplet actuation, inhibition relief, and amplification sensing. DOTS qPCR has sample-to-answer times as short as 3 min 30 s. In infective endocarditis diagnosis, DOTS qPCR demonstrates reproducibility, differentiation of antibiotic susceptibility, subpicogram limit of detection, and thermocycling speeds of up to 28 s/cycle in the presence of tissue contaminants. Langmuir and Gibbs adsorption isotherms are used to describe the decreasing interfacial tension upon amplification. Moreover, a log-linear relationship with low threshold cycles is presented for real-time quantification by imaging the droplet-on-thermocouple silhouette with a smartphone. DOTS qPCR resolves several limitations of commercially available real-time PCR systems, which rely on fluorescence detection, have substantially higher threshold cycles, and require expensive optical components and extensive sample preparation. Due to the advantages of low threshold cycle detection, we anticipate extending this technology to biological research applications such as single cell, single nucleus, and single DNA molecule analyses. Our work is the first demonstrated use of interfacial effects for sensing reaction progress, and it will enable point-of-care molecular diagnosis of infections.

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Mårtensson, Gustav. « The effect of lifting speed on factors related to resistance training : A study on muscle activity, amount of repetitions performed, and time under tension during bench press in young males ». Thesis, Högskolan i Halmstad, Bio- och miljösystemforskning (BLESS), 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:hh:diva-28522.

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Abstract Background Many different variables are important to consider when creating resistancetraining programs. However the lifting speed that exercises are performed with has not beenstudied as extensively as many of the other factors. Some research has indicated that trainingwith specific lifting speeds results in improved strength or hypertrophy adaptations comparedto other lifting tempos, but more research is needed to reach better knowledge on what liftingspeeds are optimal for specific goals.Aim The aim of this study was to analyze the effect of various lifting speeds on differentfactors known to influence resistance training. The measured variables were muscle activity,maximum amount of repetitions performed and time under tension during bench press.Method Thirteen males performed bench press at their individual 6 RM. The exercise wasperformed to fatigue with three different lifting tempos (4 second repetitions, 6 secondrepetitions and repetitions intentionally performed as fast as possible). Number of repetitions performed and total time under tension for each test was recorded in seconds. Surfaceelectromyography (EMG) was used to register muscle activity of pectoralis major anddeltoideus anterior. Reference values were gathered using MVIC (Maximum voluntaryisometric contraction) tests.Results EMG amplitudes were higher in pectoralis major when a fast lifting speed (60.1 ± 7.3% of MVIC) was used compared to the medium (54.8 ± 10.2) and slow (54.3 ± 7.1)conditions. More repetition were performed with faster lifting speeds. The time under tensionwas longer for the slow and medium lifting tempos than for the fast lifting tempo.Conclusion The result from this study can be considered when designing resistance trainingprograms. Based on the increased performance and muscle activity associated with the fastlifting tempo, faster lifting speeds may be beneficial when the training goal is to increasestrength levels. It is difficult to draw any conclusions regarding the optimal lifting tempo forspecific training designed to increase hypertrophy, but the time under tension appears to belonger for slower lifting speeds.

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CICIOTTI, FULVIO. « Oscillator-Based CMOS Readout Interfaces for Gas Sensing Applications ». Doctoral thesis, Università degli Studi di Milano-Bicocca, 2019. http://hdl.handle.net/10281/241089.

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Il rilevamento di gas tossici e pericolosi è sempre stato necessario per motivi di sicurezza. Negli ultimi anni, in particolare, l’attenzione per lo sviluppo di sistemi portatili e a basso costo per il rilevamento dei gas è aumentata notevolmente. Questa tesi presenta circuiti CMOS versatili, veloci, ad alta precisione e basso consumo per applicazioni portatili di rilevamento di gas. I sensori target sono i Metal Oxide Semiconductor (MOX). Questi sensori sono ampiamente utilizzati per la loro intrinseca compatibilità con le tecnologie MEMS integrate. Le tipologie di lettura scelte sono basate su un oscillatore controllato dalla resistenza del sensore stessa, in modo da ottenere una conversione resistenza-tempo. Ciò garantisce un ampio range dinamico, una buona precisione e la capacità di far fronte alle grandi variazioni di resistenza del sensore MOX. Quattro diversi prototipi sono stati sviluppati e testati con successo. Sono state anche eseguite misurazioni chimiche con un vero sensore SnO2 MOX, validando i risultati ottenuti. Le misure hanno mostrato come il sensore e l’interfaccia sia in grado di rilevare fino a 5ppm di CO in aria. Gli ASIC sono in grado di coprire 128 dB di DR a 4Hz di output data rate digitale, o 148 dB a 0.4Hz, garantendo un errore relativo percentuale sempre migliore dello 0,4% (SNDR> 48 dB). Le prestazioni target sono state raggiunte con aggressive strategie di progettazione e ottimizzazione a livello di sistema. È stata utilizzata una tecnologia CMOS a 130nm fornita da Infineon Technologies AG. La scelta di un nodo tecnologico così scalato (rispetto alle tipiche implementazioni in questo settore) ha consentito di ridurre ulteriormente i consumi fino a circa 450 μA. Inoltre, questo lavoro introduce la possibilità di utilizzare la stessa architettura basata su oscillatore per eseguire la lettura di sensori capacitivi. I risultati delle misurazioni con sensori capacitivi MEMS hanno mostrato 116 dB di DR, con un SNR di 74 dB a 10Hz di velocità di trasmissione dati digitale. Le architetture sviluppate in questa tesi sono compatibili con gli standard moderni nel settore del rilevamento del gas per dispositivi portatili.
Detection of toxic and dangerous gases has always been a need for safety purpose and, in recent years, portable and low-cost gas sensing systems are becoming of main interest. This thesis presents fast, high precision, low-power, versatile CMOS interface circuits for portable gas sensing applications. The target sensors are Metal Oxide Semiconductor (MOX) sensors which are widely used due to their inherent compatibility with integrated MEMS technologies. The chosen readout typologies are based on the time-domain Resistor-Controlled Oscillator. This guarantees wide dynamic range, good precision and the ability to cope with the large MOX sensor resistance variations. Four different prototypes have been successfully developed and tested. Chemical measurements with a real SnO2 MOX sensor have also been performed to validate the results, showing a minimum CO detection capability in ambient air of 5 ppm. The ASICs are able to cover 128 dB of DR at 4 Hz of digital output data rate, or 148 dB at 0.4 Hz, while providing a relative error always better than 0.4% (SNDR >48 dB). Target performances have been achieved with aggressive design strategies and system-level optimization, and using a scaled (compared to typical implementations in this field) 130nm CMOS technology provided by Infineon Technologies AG. Power consumption is about 450 μA. Moreover, this work introduces the possibility to use the same oscillator-based architecture to perform capacitive sensors readout. Measurement results with capacitive MEMS sensors have shown 116 dB of DR in CSENS mode, with an SNR of 74 dB at 10 Hz of digital output data rate. The architectures developed in this thesis are compatible with the modern standards in the portable gas sensing industry.

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Ainegren, Mats. « Roller skis' rolling resistance and grip characteristics : influences on physiological and performance measures in cross-country skiers ». Doctoral thesis, Mittuniversitetet, Institutionen för teknik och hållbar utveckling, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:miun:diva-16446.

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The aim of this thesis was to investigate roller ski characteristics; classical and freestyle roller skis’ rolling resistance coefficients (μR) and classical style roller skis’ static friction coefficients (μS), and to study the influence of different μR and μS on cross-country skiers’ performance and both physiological and biomechanical indices. The aim was also to study differences in skiing economy and efficiency between recreational skiers, female and male junior and senior elite cross-country skiers.The experiments showed that during a time period of 30 minutes of rolling on a treadmill (warm-up), μR decreased significantly (p<0.05) to about 60-65 % and 70-75 % of its initial value for freestyle and classical roller skis respectively. Also, there was a significant influence of normal force on μR, while different velocities and inclinations of the treadmill only resulted in small changes in μR.The study of the influence on physiological variables of a ~50 % change in μR showed that during submaximal steady rate exercise, external power, oxygen uptake, heart rate and blood lactate were significantly changed, while there were non-significant or only small changes to cycle rate, cycle length and ratings of perceived exertion. Incremental maximal tests showed that time to exhaustion was significantly changed and this occurred without a change in maximal power, maximal oxygen uptake, maximal heart rate and blood lactate, and that the influence on ratings of perceived exertion was non-significant or small.The study of classical style roller skis μS showed values that were five to eight times more than the values of μS reported from on-snow skiing with grip-waxed cross-country skis.The subsequent physiological and biomechanical experiments with different μS showed a significantly lower skiing economy (~14 % higher v̇O2), higher heart rate, lower propulsive forces coming from the legs and shorter time to exhaustion (~30 %) when using a different type of roller ski with a μS similar to on-snow skiing, while there was no difference between tests when using different pairs of roller skis with a (similar) higher μS.The part of the thesis which focused on skiing economy and efficiency as a function of skill, age and gender, showed that the elite cross-country skiers had better skiing economy and higher gross efficiency (5-18 %) compared with the recreational skiers, and the senior elite had better economy and higher efficiency (4-5 %) than their junior counterparts, while no differences could be found between the genders.
Syftet med denna avhandling var att undersöka fristils- och klassiska rullskidors rullmotståndskoefficienter (μR) och klassiska rullskidors statiska friktionskoefficienter (μS) samt effekter av olika μR och μS på längdskidåkares prestation vid rullskidåkning på rullande band. Syftet var även att undersöka s.k. åkekonomi och mekanisk verkningsgrad mellan motionärer och kvinnliga och manliga junior- och seniorlängdskidåkare på elitnivå.Experimenten visade att under en period av 30 minuters kontinuerligt rullande, på rullande band, så sjönk μR signifikant (p<0.05) till 60-65 % och 70-75 % av initiala värden, för fristils- respektive klassiska rullskidor. Undersökandet av olika normalkrafter, hastigheter och lutningars påverkan på μR resulterade i en signifikant, negativ korrelation för μR som funktion av normalkraft, medan olika hastigheter och lutningar endast medförde små förändringar av μR.Studien som undersökte fysiologiska effekter av olika μR visade, vid submaximala konstanta arbetsbelastningar, att yttre effekt, syreupptagning, hjärtfrekvens och blodlaktat förändrades signifikant vid ~50 % förändring av μR. Försökspersonernas frekvens och sträcka per frekvens samt skattning av upplevd ansträngning resulterade dock i mestadels icke signifikanta eller små förändringar. Protokollen med successivt ökande arbetsbelastning (maxtest) resulterade i signifikant förändrad tid till utmattning, vid ~50 % förändring av μR. Detta inträffade utan signifikant skillnad i maximal syreupptagning, hjärtfrekvens och blodlaktat, vilket även mestadels gällde för skattning av upplevd ansträngning.Experimenten som undersökte klassiska rullskidors μS visade att dessa erhöll värden som är fem till åtta gånger högre än vad som rapporterats från studier av μS på snö med fästvallade skidor.Den efterföljande studien som undersökte fysiologiska och biomekaniska influenser av olika μS visade, vid submaximala konstanta arbetsbelastningar, att åkekonomin försämrades (~14 % högre syreförbrukning), hjärtfrekvensen ökade, den framåtdrivande kraften från benen på rullskidorna minskade samt att det blev kortare tid till utmattning (~30 %), vid maxtest, när skidåkarna använde rullskidor med en μS i likhet med vad som rapporterats för skidåkning på snö. För arbetsförsöken med olika rullskidor av olika fabrikat med en högre, och likartad, μS förelåg ingen skillnad i de undersökta variablerna.Studien som undersökte åkekonomi och mekanisk verkningsgrad som funktion av prestationsnivå, ålder och kön, visade att elitskidåkarna hade bättre åkekonomi och verkningsgrad (5-18 %) i jämförelse med motionärerna, att seniorerna hade bättre åkekonomi och verkningsgrad (4-5 %) än juniorerna och att ingen skillnad kunde konstateras mellan könen.

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Rosa, Regis Goulart. « Desfechos clínicos em neutropenia febril ». reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2015. http://hdl.handle.net/10183/119418.

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Neutropenia febril (NF) constitui complicação frequente do tratamento quimioterápico do câncer e está associada a altas taxas de morbimortalidade. O reconhecimento dos principais fatores associados ao desenvolvimento de desfechos clínicos desfavoráveis na NF é fundamental, uma vez que estes podem ser utilizados como marcadores prognósticos ou alvos terapêuticos. Este estudo objetiva determinar os principais fatores associados com mortalidade, tempo de hospitalização, incidência de bacteremia por patógenos multirresistentes e incidência de choque séptico no início da febre em pacientes hospitalizados com NF secundária à quimioterapia citotóxica para o câncer. Na presente coorte prospectiva composta por 305 episódios consecutivos de NF (em 169 pacientes com câncer) realizada em um hospital terciário no período de outubro de 2009 a agosto de 2011, as seguintes questões de pesquisa foram avaliadas: impacto do tempo de início da antibioticoterapia na mortalidade em 28 dias; fatores relacionados com tempo de hospitalização; impacto dos fatores microbiológicos da bacteremia no desenvolvimento de choque séptico no início do episódio de NF; fatores de risco para bacteremia por patógenos multirresistentes; impacto da bacteremia por Staphylococcus coagulase-negativo na mortalidade em 28 dias. Em 5 publicações distintas, os seguintes resultados foram notados: o atraso do início da antibioticoterapia está associado a maiores taxas de mortalidade em 28 dias; neoplasia hematológica, regimes quimioterápicos de altas doses, duração da neutropenia e bacteremia por Gram-negativos multirresistentes estão associados com períodos prolongados de internação por NF; infecção de corrente sanguínea polimicrobiana, bacteremia por Escherichia coli e bacteremia por Streptococcus viridans estão associados a choque séptico no início do episódio de NF; idade avançada, duração da neutropenia e presença de cateter venoso central estão associados com bacteremia por patógenos multirresistentes; bacteremia por Staphylococcus coagulase-negativo está associada a menores taxas de mortalidade em 28 dias quando comparado à bacteremia por outros patógenos.
Febrile neutropenia (FN) is a common complication of cancer chemotherapy and is associated with high morbidity and mortality rates. Recognition of the main factors associated with the development of adverse clinical outcomes in FN is crucial, given that these factors can be used as prognostic markers or therapeutic targets. This study aims to determine the main factors associated with mortality, length of hospital stay, incidence of bacteremia by multidrug-resistant pathogens and incidence of septic shock at the onset of fever in hospitalized patients with FN secondary to cancer cytotoxic chemotherapy. In the present prospective cohort of 305 FN episodes (in 169 cancer patients) conducted at a tertiary hospital from October 2009 to August 2011, the following research questions were evaluated: impact of time to antibiotic administration on 28-day mortality; factors associated with length of hospital stay; impact of microbiological factors of bacteremia on the development of septic shock at the onset of FN; risk factors for bacteremia by multidrug-resistant pathogens; impact of coagulasenegative Staphylococcus bacteremia on 28-day mortality. In 5 distinct publications, the following results were noted: delay of antibiotic administration is associated with higher 28-day mortality rates; hematologic malignancy, high-dose chemotherapy regimens, duration of neutropenia and bacteremia by multidrug-resistant Gram-negative bacteria are associated with prolonged length of hospital stay; polymicrobial bloodstream infection, bacteremia by Escherichia coli, and bacteremia by viridans sreptococci are associated with septic shock at the onset of FN; advanced age, duration of neutropenia and presence of indwelling central venous catheters are associated with bacteremia by multidrug-resistant pathogens; coagulase-negative Staphylococcus bacteremia is associated with lower 28-day mortality rates compared with bacteremia by other pathogens.

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Livres sur le sujet "Resistance-to-time"

A time to fight back : True stories of wartime resistance. Boston : Houghton Mifflin Co., 1996.

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Maya resistance to Spanish rule : Time and history on a colonial frontier. Albuquerque : University of New Mexico Press, 1989.

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Hill, C. J. Erasing time. New York, NY : Katherine Tegen Books, 2012.

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Time for revolution. New York : Continuum, 2003.

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Space-time talk : New Testament hermeneutics : a philosophical and theological approach. Virginia Beach, Va., U.S.A : Heritage Research House, 1988.

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Hill, C. J. Echo in time. New York, NY : Katherine Tegen Books, an imprint of HarperCollinsPublishers, 2014.

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Joan, McAlpine, dir. A time to rage. Edinburgh : Polygon, 1994.

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M'Gee, Thomas D'Arcy. A history of the attempts to establish the Protestant Reformation in Ireland : And the successful resistance of that people (time, 1540-1830). Boston : Patrick Donahoe, 1986.

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Murray, Martin J. South Africa : Time of agony, time of destiny ; the upsurge of popular protest. London : Verso, 1987.

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Time for revolution. London : Bloomsbury, 2013.

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Chapitres de livres sur le sujet "Resistance-to-time"

Felippi, Vera. « Handloom : Resistance to Time and Challenges ». Dans Sustainable Textiles : Production, Processing, Manufacturing & ; Chemistry, 1–19. Singapore : Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-16-5272-1_1.

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López-Lozano, José-María, Dominique L. Monnet, Pilar Campillos Alonso, Alberto Cabrera Quintero, Nieves Gonzalo Jiménez, Alberto Yagüe Muñoz, Claudia Thomas, Arielle Beyaert, Mark Stevenson et Thomas V. Riley. « Applications of Time-series Analysis to Antibiotic Resistance and Consumption Data ». Dans Antibiotic Policies, 447–63. Boston, MA : Springer US, 2005. http://dx.doi.org/10.1007/0-387-22852-7_24.

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Kim, Han-Seul, Jae-Gyu Shin, Won-Sup Chung et Sang-Hee Son. « A Resistance Deviation-To-Time Interval Converter Using Second Generation Current Conveyors ». Dans Communications in Computer and Information Science, 131–36. Berlin, Heidelberg : Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-35594-3_18.

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Ahn, Sang-Won. « Evaluation of Genetic Resistance to Rice Blast : Searching for Varietal Resistance Stable over Space and Durable over Time ». Dans Major Fungal Diseases of Rice, 131–43. Dordrecht : Springer Netherlands, 2001. http://dx.doi.org/10.1007/978-94-017-2157-8_10.

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De Marcellis, A., C. Di Carlo, G. Ferri, V. Stornelli, A. Depari, A. Flammini et D. Marioli. « A Novel Calibration-Less CCII-Based Resistance-to-Time Front-End for Gas Sensor Interfacing ». Dans Lecture Notes in Electrical Engineering, 279–84. Dordrecht : Springer Netherlands, 2009. http://dx.doi.org/10.1007/978-90-481-3606-3_54.

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Tanaka, Takeyoshi, et Tensei Mizukami. « A Method for Translating Compartment Fire Durations to Equivalent Fire Resistance Time at Standard Fire Test Condition ». Dans The Proceedings of 11th Asia-Oceania Symposium on Fire Science and Technology, 521–34. Singapore : Springer Singapore, 2019. http://dx.doi.org/10.1007/978-981-32-9139-3_38.

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Ndayihanzamaso, Privat, Sheryl Bothma, Diane Mostert, George Mahuku et Altus Viljoen. « An Optimised Greenhouse Protocol for Screening Banana Plants for Fusarium Wilt Resistance ». Dans Efficient Screening Techniques to Identify Mutants with TR4 Resistance in Banana, 65–77. Berlin, Heidelberg : Springer Berlin Heidelberg, 2022. http://dx.doi.org/10.1007/978-3-662-64915-2_5.

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AbstractFusarium wilt, caused by the soil-borne fungus Fusarium oxysporum f. sp. cubense (Foc), is considered one of the most devastating diseases of banana in the world. Effective management of Fusarium wilt is only achieved by planting banana varieties resistant to Foc. Resistant bananas, however, require many years of breeding and field-testing under multiple geographical conditions. Field evaluation is reliable but time consuming and expensive. Small plant screening methods are, therefore, needed to speed up the evaluation of banana varieties for Foc resistance. To this end, a small plant screening method for resistance to banana Fusarium wilt is presented. The method proposes the planting of 2- to 3-month-old banana plants in soil amended with 10 g Foc-colonised millet seeds. Rhizome discoloration is then evaluated to rank the disease resistance response. The optimized millet seed technique could be useful in mass screening of newly developed genotypes for resistance to Foc.

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Marti, Irene. « Space, Time, Embodiment ». Dans Doing Indefinite Time, 95–110. Cham : Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-031-12590-4_3.

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AbstractThis chapter presents the theoretical framework of the study. In this book, the prison and the experience of imprisonment are analysed using space, time and embodiment as key concepts. The study adopts a phenomenological and pragmatist perspective, drawing on the notion of inhabiting. The chapter argues that this analytical approach provides a unique and fruitful perspective on the prison and the subjective experience of incarceration. First, it allows us to understand the prison not as a space in the sense of a (pre-defined) container, but as a formally established set of arrangements of space and time that are lived. Second, the concept of inhabiting enables us to refocus the lens of prison studies away from the often-applied framework of power and resistance and, instead, to explore prisoners’ embodied, agentic and practical engagement with imprisonment.

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Bhavani, Sridhar, Ravi P. Singh, David P. Hodson, Julio Huerta-Espino et Mandeep Singh Randhawa. « Wheat Rusts : Current Status, Prospects of Genetic Control and Integrated Approaches to Enhance Resistance Durability ». Dans Wheat Improvement, 125–41. Cham : Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-90673-3_8.

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AbstractThe three rusts are the most damaging diseases of wheat worldwide and continue to pose a threat to global food security. In the recent decades, stem rust races belonging to the Ug99 (TTKSK) and Digalu (TKTTF) race group resurfaced as a major threat in Africa, the Middle East and Europe threatening global wheat production. In addition, the evolution and migration of new aggressive races of yellow rust adapted to warmer temperatures into Europe and Asia from Himalayan region are becoming a significant risk in several wheat production environments. Unique and complex virulence patterns, continuous evolution to overcome effective resistance genes in varieties, shifts in population dynamics, transboundary migration have resulted in localized/regional epidemics leading to food insecurity threats. This underscores the need to identify, characterize, and deploy effective rust resistant genes from diverse sources into pre-breeding lines and future wheat varieties. The use of genetic resistance and deployment of multiple race specific and pleiotropic adult plant resistance genes in wheat lines can enhance resistance durability. Recent advances in sequencing annotated wheat reference genome with a detailed analysis of gene content among sub-genomes will not only accelerate our understanding of the genetic basis of rust resistance bread wheat, at the same time wheat breeders can now use this information to identify genes conferring rust resistance. Progress in genetic mapping techniques, new cloning techniques and wheat transformation methods over the last two decades have not only resulted in characterizing new genes and loci but also facilitated rapid cloning and stacking multiple genes as gene cassettes which can be future solution for enhancing durable resistance.

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Smith, Richard D., et Joanna Coast. « The Economics of Resistance Through an Ethical Lens ». Dans Ethics and Drug Resistance : Collective Responsibility for Global Public Health, 279–94. Cham : Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-27874-8_17.

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Abstract Economics is concerned with the analysis of choice and the efficient use of resources. Markets for antibiotics are heavily affected by their ‘public good’ nature and the externality that results from their consumption in terms of resistance. The non-excludability and non-rivalry associated with knowledge production in antibiotic development also has implications for the supply of antibiotics. On the demand side there are ethical issues associated with free-riding by consumers, free-riding across nations and free-riding across time. On the supply side, the lack of a pipeline for new antibiotics for the future causes both ethical and economic issues – and from both perspectives, efforts should perhaps focus more on alternatives to antibiotics and adjustments to heath care systems to reduce reliance on antibiotics. Indeed, unlike many areas of health care, where economics and ethical perspectives may differ, antimicrobial resistance is a case where the two perspectives align in terms of ensuring efficient and sustainable development and use of this precious resources. All strategies for dealing with resistance should share the same goals of achieving an optimal balance in the use of antimicrobial agents and explicit consideration of the distributional implications.

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Actes de conférences sur le sujet "Resistance-to-time"

Hunasekattte, Dhruva. « A Resistance-to-time Convertor to enhance Resistive Sensitivity of Embedded Systems ». Dans 2020 4th International Conference on Electronics, Communication and Aerospace Technology (ICECA). IEEE, 2020. http://dx.doi.org/10.1109/iceca49313.2020.9297378.

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Park, Ji-Man, et Sung-Ik Jun. « A resistance deviation-to-time interval converter for resistive sensors ». Dans 2008 IEEE International SOC Conference (SOCC). IEEE, 2008. http://dx.doi.org/10.1109/socc.2008.4641488.

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GRASSI, MARCO, PIERO MALCOVATI, GIANPIERO DE IACO et ANDREA BASCHIROTTO. « AN INTEGRATED WIDE-RANGE RESISTANCE-TO-TIME CONVERTER WITH DECOUPLED OSCILLATOR ». Dans Proceedings of the 10th Italian Conference. WORLD SCIENTIFIC, 2008. http://dx.doi.org/10.1142/9789812833532_0104.

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Kurppa, R., H. Seppänen, A. Meriläinen, M. Oinonen, E. Hæggström, Donald O. Thompson et Dale E. Chimenti. « REAL-TIME NONDESTRUCTIVE CONTACT RESISTANCE METHOD TO ESTIMATE WIRE BOND PULL FORCE ». Dans REVIEW OF PROGRESS IN QUANTITATIVE NONDESTRUCTIVE EVALUATION VOLUME 29. AIP, 2010. http://dx.doi.org/10.1063/1.3362259.

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Di Natale, G., M. L. Flottes et B. Rouzeyre. « Evaluation of Resistance to Differential Power Analysis : Execution Time Optimizations for Designers ». Dans 2010 Fifth IEEE International Symposium on Electronic Design, Test & Applications. IEEE, 2010. http://dx.doi.org/10.1109/delta.2010.50.

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Barenghi, Alessandro, Guido Bertoni, Fabrizio De Santis et Filippo Melzani. « On the Efficiency of Design Time Evaluation of the Resistance to Power Attacks ». Dans 2011 14th Euromicro Conference on Digital System Design (DSD). IEEE, 2011. http://dx.doi.org/10.1109/dsd.2011.103.

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Nakagawa, Shuya, Kaito Horikoshi et Hiroki Ishikuro. « A High-Resolution Time-Based Resistance-to-Digital Converter with TDC and Counter ». Dans 2018 IEEE 61st International Midwest Symposium on Circuits and Systems (MWSCAS). IEEE, 2018. http://dx.doi.org/10.1109/mwscas.2018.8623991.

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Zahangir, M., Sheroz Khan, I. Adam, K. Abdul Kadir, A. N. Nordin et S. N. Ibrahim. « A proposed resistance-to-time converter with switching impulse calibrators for resistive bridge sensors ». Dans 2017 IEEE 4th International Conference on Smart Instrumentation, Measurement and Application (ICSIMA). IEEE, 2017. http://dx.doi.org/10.1109/icsima.2017.8312017.

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Haque, Md Nafiul, et Murad Y. Abu-Farsakh. « Development of Empirical Models to Estimate the Increase in Pile Resistance (Set-Up) with Time ». Dans Geotechnical Frontiers 2017. Reston, VA : American Society of Civil Engineers, 2017. http://dx.doi.org/10.1061/9780784480465.020.

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« Does adding a spatial component to a herbicide resistance population model improve understanding and predictions of the buildup of herbicide resistance over time ? » Dans 21st International Congress on Modelling and Simulation (MODSIM2015). Modelling and Simulation Society of Australia and New Zealand, 2015. http://dx.doi.org/10.36334/modsim.2015.b4.somerville.

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Rapports d'organisations sur le sujet "Resistance-to-time"

Olek, J., Menashi Cohen et Charles Scholer. Use of Modulus of Rupture, Fatigue Resistance and Maturity in Determining Opening to Traffic Time for Concrete Pavements. West Lafayette, IN : Purdue University, 2003. http://dx.doi.org/10.5703/1288284313341.

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Davis, Eric L., Yuji Oka, Amit Gal-On, Todd Wehner et Aaron Zelcer. Broad-spectrum Resistance to Root-Knot Nematodes in Transgenic Cucurbits. United States Department of Agriculture, juin 2013. http://dx.doi.org/10.32747/2013.7593389.bard.

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Root-knot nematodes (RKN), Meloidogyne spp., are extremely destructive pathogens of cucurbit crops grown in the United States and Israel. The safety and environmental concerns of toxic nematicides, and limited sources of natural cucurbit resistance to the four major species of Meloidogyne that threaten these crops in Israel and the U.S., have emphasized the use of biotechnology to develop cucurbits with novel RKN resistance. The U.S. scientists have identified over 40 unique RKN parasitism genes that encode nematode secretions involved in successful plant root infection by RKN, and they have demonstrated that expression of a double-stranded RNA (dsRNA) complementary to a RKN parasitism gene (called 16DIO) in Arabidopsis thaliana induced RNA interference (RNAi)-mediated silencing of the RKN16DlO gene and produced transgenic plants with strong resistance to all four major RKN species. The expression 8D05 parasitism gene was found to coincide with the timing of upregulation of NtCel7 promoter (identified to be upregulated in giantcells by US scientists). NtCel7 promoter was used to express the genes at the right time (early stages of infection) and in the right place (giant-cells) in transgenic plants. US partners produced NtCel7 (nematode-induced promoter)-driven 16DlO-RNAi and 8DOS-RNAi constructs, pHANNIBAL 4D03-RNAi construct and modified 16DlO-RNAi construct (for increased RNAi expression and efficacy) for cucurbit transformation in Israel. In Arabidopsis, some 16DlO-RNAi plant lines show greater levels of resistance to M. incognita than others, and within these lines resistance of greater than 90% reduction in infection is observed among almost all replicates in US. The level of observed nematode resistance is likely to be directly correlated with the level of RNAi expression in individual plants. In Israel, all the RKN parasitism genes-RNAi constructs were successfully transformed into cucumber and melon. The transgenic lines were evaluated for expression of the transgene siRNA in leaves and roots. Those displaying transgene siRNA accumulation were passed on for nematode resistance analysis. Rl seedlings from different lines were subjected to evaluation for resistance to M. javanica. None of the lines was resistant to the nematode in contrast with US partner's results in Arabidopsis. This could be for the following reasons: a) The level of transgene siRNA was insufficient in cucumber and tomato to cause resislance. b) 111e nemalode species on cucwnber IIlay be different ur act in a different manner. c) The assay was performed in soil with a high level of nematode inoculation, and not in petri dish, which may not permit the observation of a low level of resistance.

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Currier, Brad, Jonathan Mcleod et Stuart Phillips. The Influence of Resistance Exercise Training Prescription Variables on Muscle Mass, Muscle Strength, and Physical Function in Healthy Adults : An Umbrella Review. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, février 2022. http://dx.doi.org/10.37766/inplasy2022.2.0028.

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Review question / Objective: To determine how resistance training prescription variables (load, sets, frequency, time under tension, etc) affect muscle mass, muscle strength, and physical function in healthy adults. Condition being studied: To determine how resistance training prescription variables (load, sets, frequency, time under tension, etc) affect muscle mass (hypertrophy), muscle strength, and physical function in healthy adults. Information sources: OVID MEDLINE, SPORTDiscus, Web of Science.

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Jorgensen, Frieda, John Rodgers, Daisy Duncan, Joanna Lawes, Charles Byrne et Craig Swift. Levels and trends of antimicrobial resistance in Campylobacter spp. from chicken in the UK. Food Standards Agency, septembre 2022. http://dx.doi.org/10.46756/sci.fsa.dud728.

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Campylobacter spp. are the most common bacterial cause of foodborne illness in the UK, with chicken considered to be the most important vehicle of transmission for this organism. It is estimated there are 500,000 cases of campylobacteriosis in the UK annually, with Campylobacter jejuni (C. jejuni) and Campylobacter coli (C. coli) accounting for approximately 91% and 8 % of infections, respectively. Although severe infection in humans is uncommon, treatment is seldom needed for human infection but usually involves the administration of a macrolide (e.g., azithromycin) or a fluoroquinolone (e.g., ciprofloxacin). An increased rate of resistance in Campylobacter in chicken to such antimicrobials could limit effective treatment options for human infections and it is therefore important to monitor changes in rates of resistance over time. In this report we analysed trends in antimicrobial resistance (AMR) in C. jejuni and C. coli isolated from chicken in the UK. The chicken samples were from chicken reared for meat (ie. broiler chicken as opposed to layer chicken (ie. egg-laying chicken)) and included chicken sampled at slaughterhouses as well as from retail stores in the UK. Datasets included AMR results from retail surveys of Campylobacter spp. on chicken sampled in the UK from various projects in the time period from 2001 to 2020. In the retail surveys, samples were obtained from stores including major and minor retail stores throughout the UK (in proportion to the population size of each nation) and Campylobacter spp. testing was performed using standard methods with the majority of isolates obtained from direct culture on standard media (mCCDA). Data from national scale surveys of broiler chicken, sampling caecal contents and carcase neckskins at slaughterhouses, undertaken by APHA in 2007/2008, and between 2012 and 2018 were also included in the study. In the APHA-led surveys, Campylobacter were isolated using standard culture methods (culture onto mCCDA) and antimicrobial susceptibility testing was performed by a standard microbroth dilution method to determine the minimum inhibitory concentration (MIC) of isolates. Care was taken when comparing data from different studies as there had been changes to the threshold used to determine if an isolate was susceptible or resistant to an antimicrobial in a small number of scenarios. Harmonised thresholds (using epidemiological cut-off (ECOFF) values) were employed to assess AMR with appropriate adjustments made where required to allow meaningful comparisons of resistance prevalence over time. Data from additional isolates where resistance to antimicrobials were predicted from genome sequence data were also considered.

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El Badawy, Amro, et Ashraf Rahim. Evaluation of Nanoclay Additives for Improving Resistance to Moisture Damage in Hot Mix Asphalt (HMA). Mineta Transportation Institute, janvier 2023. http://dx.doi.org/10.31979/mti.2023.2151.

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Transportation has an enormous impact on the U.S. economy and on the lives of all Americans. Many modes of transportation rely on pavement, but pavement conditions deteriorate over time because of the combined effects of traffic and climate. Exposure to moisture often causes premature failure of asphalt pavements as it reduces the stiffness of the asphalt and enables stripping of the asphalt from the aggregate. This research evaluates the effectiveness of clay nanomaterials (i.e., nanoclays) in improving the resistance of hot mix asphalt (HMA) to moisture damage and compares the enhancement results to anti-stripping additives commonly used in pavement construction. Two types of surface-modified nanoclay, lime-treated aggregate, and two amine-based liquid antistripping agents (HP Plus and LOF 6500) were evaluated for improving HMA’s moisture resistance. All additives tested for reducing moisture damage resulted in dry and wet tensile strength of the modified mixes higher than the minimum specified by Caltrans 2018 Standard Specifications (100 psi for dry tensile strength and 70 psi for wet tensile strength). The Tensile Strength Ratio (TSR) of all HMA modified mixes was higher than 0.80, which is the minimum specified by the Superpave mix design method (Asphalt Mix Design Methods MS-2, Asphalt Institute) and exceeded the TSR of the control mix. The TSR for HMA mixes modified using nanoclays were comparable to those for HMA mixes modified using liquid antistripping and lime slurry treated aggregate. Liquid antistripping agents tested herein were the least costly additive at an approximately $2.0/ton added cost. This research can be used to better understand pavement deterioration to enable the most efficient and cost-effective construction and preservation of our nation's critical transportation infrastructure.

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McCarthy, Noel, Eileen Taylor, Martin Maiden, Alison Cody, Melissa Jansen van Rensburg, Margaret Varga, Sophie Hedges et al. Enhanced molecular-based (MLST/whole genome) surveillance and source attribution of Campylobacter infections in the UK. Food Standards Agency, juillet 2021. http://dx.doi.org/10.46756/sci.fsa.ksj135.

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This human campylobacteriosis sentinel surveillance project was based at two sites in Oxfordshire and North East England chosen (i) to be representative of the English population on the Office for National Statistics urban-rural classification and (ii) to provide continuity with genetic surveillance started in Oxfordshire in October 2003. Between October 2015 and September 2018 epidemiological questionnaires and genome sequencing of isolates from human cases was accompanied by sampling and genome sequencing of isolates from possible food animal sources. The principal aim was to estimate the contributions of the main sources of human infection and to identify any changes over time. An extension to the project focussed on antimicrobial resistance in study isolates and older archived isolates. These older isolates were from earlier years at the Oxfordshire site and the earliest available coherent set of isolates from the national archive at Public Health England (1997/8). The aim of this additional work was to analyse the emergence of the antimicrobial resistance that is now present among human isolates and to describe and compare antimicrobial resistance in recent food animal isolates. Having identified the presence of bias in population genetic attribution, and that this was not addressed in the published literature, this study developed an approach to adjust for bias in population genetic attribution, and an alternative approach to attribution using sentinel types. Using these approaches the study estimated that approximately 70% of Campylobacter jejuni and just under 50% of C. coli infection in our sample was linked to the chicken source and that this was relatively stable over time. Ruminants were identified as the second most common source for C. jejuni and the most common for C. coli where there was also some evidence for pig as a source although less common than ruminant or chicken. These genomic attributions of themselves make no inference on routes of transmission. However, those infected with isolates genetically typical of chicken origin were substantially more likely to have eaten chicken than those infected with ruminant types. Consumption of lamb’s liver was very strongly associated with infection by a strain genetically typical of a ruminant source. These findings support consumption of these foods as being important in the transmission of these infections and highlight a potentially important role for lamb’s liver consumption as a source of Campylobacter infection. Antimicrobial resistance was predicted from genomic data using a pipeline validated by Public Health England and using BIGSdb software. In C. jejuni this showed a nine-fold increase in resistance to fluoroquinolones from 1997 to 2018. Tetracycline resistance was also common, with higher initial resistance (1997) and less substantial change over time. Resistance to aminoglycosides or macrolides remained low in human cases across all time periods. Among C. jejuni food animal isolates, fluoroquinolone resistance was common among isolates from chicken and substantially less common among ruminants, ducks or pigs. Tetracycline resistance was common across chicken, duck and pig but lower among ruminant origin isolates. In C. coli resistance to all four antimicrobial classes rose from low levels in 1997. The fluoroquinolone rise appears to have levelled off earlier and among animals, levels are high in duck as well as chicken isolates, although based on small sample sizes, macrolide and aminoglycoside resistance, was substantially higher than for C. jejuni among humans and highest among pig origin isolates. Tetracycline resistance is high in isolates from pigs and the very small sample from ducks. Antibiotic use following diagnosis was relatively high (43.4%) among respondents in the human surveillance study. Moreover, it varied substantially across sites and was highest among non-elderly adults compared to older adults or children suggesting opportunities for improved antimicrobial stewardship. The study also found evidence for stable lineages over time across human and source animal species as well as some tighter genomic clusters that may represent outbreaks. The genomic dataset will allow extensive further work beyond the specific goals of the study. This has been made accessible on the web, with access supported by data visualisation tools.

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Sessa, Guido, et Gregory Martin. Role of GRAS Transcription Factors in Tomato Disease Resistance and Basal Defense. United States Department of Agriculture, 2005. http://dx.doi.org/10.32747/2005.7696520.bard.

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The research problem: Bacterial spot and bacterial speck diseases of tomato are causedby strains of Xanthomonas campestris pv. vesicatoria (Xcv) and Pseudomonas syringae pv.tomato (Pst), respectively. These bacteria colonize aerial parts of the plant and causesignificant losses in tomato production worldwide. Protection against Xcv and Pst bycultural practices or chemical control has been unsuccessful and there are only limitedsources of genetic resistance to these pathogens. In previous research supported in part byBARD IS-3237-01, we extensively characterized changes in tomato gene expression uponthe onset of spot and speck disease resistance. A remarkable finding of these studies wasthe inducibility in tomato leaves by both Xcv and Pst strains of genes encodingtranscriptional activator of the GRAS family, which has not been previously linked todisease resistance. Goals: Central goals of this research were to investigate the role of GRAS genes in tomatoinnate immunity and to assess their potential use for disease control.Specific objectives were to: 1. Identify GRAS genes that are induced in tomato during thedefense response and analyze their role in disease resistance by loss-of-function experiments.2. Overexpress GRAS genes in tomato and characterize plants for possible broad-spectrumresistance. 3. Identify genes whose transcription is regulated by GRAS family. Our main achievements during this research program are in three major areas:1. Identification of tomato GRAS family members induced in defense responses andanalysis of their role in disease resistance. Genes encoding tomato GRAS family memberswere retrieved from databases and analyzed for their inducibility by Pst avirulent bacteria.Real-time RT-PCR analysis revealed that six SlGRAS transcripts are induced during theonset of disease resistance to Pst. Further expression analysis of two selected GRAS genesshowed that they accumulate in tomato plants in response to different avirulent bacteria orto the fungal elicitor EIX. In addition, eight SlGRAS genes, including the Pst-induciblefamily members, were induced by mechanical stress in part in a jasmonic acid-dependentmanner. Remarkably, SlGRAS6 gene was found to be required for tomato resistance to Pstin virus-induced gene silencing (VIGS) experiments.2. Molecular analysis of pathogen-induced GRAS transcriptional activators. In aheterologous yeast system, Pst-inducible GRAS genes were shown to have the ability toactivate transcription in agreement with their putative function of transcription factors. Inaddition, deletion analysis demonstrated that short sequences at the amino-terminus ofSlGRAS2, SlGRAS4 and SlGRAS6 are sufficient for transcriptional activation. Finally,defense-related SlGRAS proteins were found to localize to the cell nucleus. 3. Disease resistance and expression profiles of transgenic plants overexpressing SlGRASgenes. Transgenic plants overexpressing SlGRAS3 or SlGRAS6 were generated. Diseasesusceptibility tests revealed that these plants are not more resistant to Pst than wild-typeplants. Gene expression profiles of the overexpressing plants identified putative direct orindirect target genes regulated by SlGRAS3 and SlGRAS6. Scientific and agricultural significance: Our research activities established a novel linkbetween the GRAS family of transcription factors, plant disease resistance and mechanicalstress response. SlGRAS6 was found to be required for disease resistance to Pstsuggesting that this and possibly other GRAS family members are involved in thetranscriptional reprogramming that takes place during the onset of disease resistance.Their nuclear localization and transcriptional activation ability support their proposed roleas transcription factors or co-activators. However, the potential of utilizing GRAS familymembers for the improvement of plant disease resistance in agriculture has yet to bedemonstrated.

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Allende López, Marcos, Diego López, Sergio Cerón, Antonio Leal, Adrián Pareja, Marcelo Da Silva, Alejandro Pardo et al. Quantum-Resistance in Blockchain Networks. Inter-American Development Bank, juin 2021. http://dx.doi.org/10.18235/0003313.

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This paper describes the work carried out by the Inter-American Development Bank, the IDB Lab, LACChain, Cambridge Quantum Computing (CQC), and Tecnológico de Monterrey to identify and eliminate quantum threats in blockchain networks. The advent of quantum computing threatens internet protocols and blockchain networks because they utilize non-quantum resistant cryptographic algorithms. When quantum computers become robust enough to run Shor's algorithm on a large scale, the most used asymmetric algorithms, utilized for digital signatures and message encryption, such as RSA, (EC)DSA, and (EC)DH, will be no longer secure. Quantum computers will be able to break them within a short period of time. Similarly, Grover's algorithm concedes a quadratic advantage for mining blocks in certain consensus protocols such as proof of work. Today, there are hundreds of billions of dollars denominated in cryptocurrencies that rely on blockchain ledgers as well as the thousands of blockchain-based applications storing value in blockchain networks. Cryptocurrencies and blockchain-based applications require solutions that guarantee quantum resistance in order to preserve the integrity of data and assets in their public and immutable ledgers. We have designed and developed a layer-two solution to secure the exchange of information between blockchain nodes over the internet and introduced a second signature in transactions using post-quantum keys. Our versatile solution can be applied to any blockchain network. In our implementation, quantum entropy was provided via the IronBridge Platform from CQC and we used LACChain Besu as the blockchain network.

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Wisniewski, Michael E., Samir Droby, John L. Norelli, Noa Sela et Elena Levin. Genetic and transcriptomic analysis of postharvest decay resistance in Malus sieversii and the characterization of pathogenicity effectors in Penicillium expansum. United States Department of Agriculture, janvier 2014. http://dx.doi.org/10.32747/2014.7600013.bard.

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Blue mold of apple caused by Penicilliumexpansumis a major postharvest disease. Selection for postharvest disease resistance in breeding programs has been ignored in favor of fruit quality traits such as size, color, taste, etc. The identification of postharvest disease resistance as a heritable trait would represent a significant accomplishment and has not been attempted in apple. Furthermore, insight into the biology of the pathogenicity of P. expansumin apple could provide new approaches to postharvest decay management. Hypothesis: Postharvest resistance of apple to P. expansumcan be mapped to specific genetic loci and significant quantitative-trait-loci (QTLs) can be identified that account for a major portion of the population variance. Susceptibility of apple fruit to P. expansumis dependent on the ability of the pathogen to produce LysM effectors that actively suppress primary and/or secondary resistance mechanisms in the fruit. Objectives: 1) Identify QTL(s) and molecular markers for blue mold resistance in GMAL4593 mapping population (‘Royal Gala’ X MalussieversiiPI613981), 2) Characterize the transcriptome of the host and pathogen (P. expansum) during the infection process 3) Determine the function of LysM genes in pathogenicity of P. expansum. Methods: A phenotypic evaluation of blue mold resistance in the GMAL4593 mapping population, conducted in several different years, will be used for QTL analysis (using MapQTL 6.0) to identify loci associated with blue mold resistance. Molecular markers will be developed for the resistance loci. Transcriptomic analysis by RNA-seq will be used to conduct a time course study of gene expression in resistant and susceptible apple GMAL4593 genotypes in response to P. expansum, as well as fungal responses to both genotypes. Candidate resistance genes identified in the transcriptomic study and or bioinformatic analysis will be positioned in the ‘Golden Delicious’ genome to identify markers that co-locate with the identified QTL(s). A functional analysis of LysM genes on pathogenicity will be conducted by eliminating or reducing the expression of individual effectors by heterologous recombination and silencing technologies. LysMeffector genes will also be expressed in a yeast expression system to study protein function. Expected Results: Identification of postharvest disease resistance QTLs and tightly-linked genetic markers. Increased knowledge of the role of effectors in blue mold pathogenic

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Rodriguez, Russell, et Stanley Freeman. Characterization of fungal symbiotic lifestyle expression in Colletotrichum and generating non-pathogenic mutants that confer disease resistance, drought tolerance, and growth enhancement to plant hosts. United States Department of Agriculture, février 2005. http://dx.doi.org/10.32747/2005.7587215.bard.

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Fungal plant pathogens are responsible for extensive annual crop and revenue losses throughout the world. To better understand why fungi cause diseases, we performed gene-disruption mutagenesis on several pathogenic Colletotrichum species and demonstrated that pathogenic isolates can be converted to symbionts (mutualism, commensalism, parasitism) expressing non-pathogenic lifestyles. The objectives of this proposal were to: 1- generate crop-specific mutants by gene disruption that express mutualistic lifestyles, 2- assess the ability of the mutualists to confer disease resistance, drought tolerance, and growth enhancement to host plants, 3- compare fslm1 sequences and their genomic locations in the different species, and 4- document the colonization process of each Colletotrichum species.It was demonstrated that wildtype pathogenic Colletotrichum isolates, can be converted by mutation from expressing a pathogenic lifestyle to symbionts expressing non-pathogenic lifestyles. In the US, mutants of Colletotrichum were isolated by homologous gene disruption using a vector containing a disrupted FSlm1 sequence while in Israel, C. acutatum mutants were selected by restriction enzyme mediated integration (REMI) transformation. One group (US) of non-pathogenic mutants conferred disease protection against pathogenic species of Colletotrichum, Fusarium, and Phytophthora; drought tolerance; and growth enhancement to host plants. These mutants were defined as mutualists and disease resistance correlated to a decrease in the time required for hosts to activate defense systems when exposed to virulent fungi. The second group (Israel) of non-pathogenic mutants did not confer disease resistance and were classified as commensals. In addition, we demonstrated that wildtype pathogenic Colletotrichum species can express non-pathogenic lifestyles, including mutualism, on plants they colonize asymptomatically. The expected long term contribution of this research to agriculture in the US and Israel is threefold. Host-specific mutualists will be utilized in the various crops to confer (1) disease resistance to reduce dependence on chemical fungicides; (2) drought tolerance to reduce water consumption for irrigation; (3) growth enhancement to increase yields.

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