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Thèses sur le sujet « Reproductive cell »

Auteur : Grafiati

Publié le 9 mars 2023

Mis à jour le 31 juillet 2025

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1

Hofsten, Jonas von. "Developmental and reproductive regulation of NR5A genes in teleosts." Doctoral thesis, Umeå : Univ, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-374.

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Giedt, Michelle Suzanne. "JAK/STAT SIGNALING REGULATES GAMETOGENESIS AND AGE-RELATED REPRODUCTIVE MAINTENANCE." UKnowledge, 2018. https://uknowledge.uky.edu/biology_etds/52.

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Cell signaling is central to integration of internal and external cues that regulate development and homeostasis. Most development is thought of as pre-adult, but limited developmental processes occur in adults. Gametogenesis incorporates elements of both these facets, with a distinct developmental plan for gamete synthesis which is regulated by integration of homeostatic inputs such as nutrient status, and environmental cues. Signaling pathways integrate and transduce information from these cues to evoke a response. A decline in homeostasis and subsequent cues occurs over time, in the case of

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3

Van, Praet Oliver. "Co-expression and interaction of cubilin and megalin in the adult male rat reproductive system." Thesis, McGill University, 2002. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=29485.

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Cubilin is a peripheral membrane protein that co-operates with the endocytic receptor megalin to mediate the endocytosis of ligands in various polarized epithelia. Megalin is expressed in the male reproductive tract where is has been implicated in the process of sperm membrane remodeling. A potential role for cubilin in the male reproductive tract has not been explored. Using RT-PCR, we found that cubilin and megalin mRNAs are expressed in the efferent ducts, corpus and cauda epididymides, and proximal and distal vas deferens. Immunohistological analysis revealed that cubilin was expressed in

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4

Mercurio, S. "ROLE OF STEROID HORMONES IN ECHINOID REPRODUCTIVE BIOLOGY." Doctoral thesis, Università degli Studi di Milano, 2014. http://hdl.handle.net/2434/230752.

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Echinoid reproductive cycle has been extensively studied in several species but the mechanisms regulating gametogenesis processes are still scarcely understood. Apart from environmental factors, different research have suggested a steroid role in gonad maturation and growth. Particularly, in echinoderms steroid involvement in reproduction has been suggested by both studies on seasonal changes of steroid levels during the gonadal cycle and experiments of hormone administration. Nevertheless, the steroid function in echinoid reproductive processes has not been clearly identified, probably due to

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5

Chen, Hsin-Ying. "T CELL RESPONSE TO INFECTION BY THE PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS." NCSU, 2005. http://www.lib.ncsu.edu/theses/available/etd-01062005-170050/.

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The purpose of the research has been to characterize the response of naïve or virus-specific swine T lymphocytes from different lymphoid compartments to Porcine Reproductive and Respiratory Syndrome Virus (PRRSV). Peripheral blood mononuclear cells (PBMCs), tracheobronchial lymph node (TLN) and lateral retropharyngeal lymph node (LLN) cells were labeled with PKH67 green fluorescence dye to measure cell proliferation and surface phenotypes were examined using anti-CD4, anti-CD8 or anti-CD25 monoclonal antibodies. Stimulation with Concanavalin A was also included as a positive control. Our resul

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6

Dias, Tânia Isabel Rodrigues Amaral. "Evaluation of cell death markers and reproductive parameters in models of diabetes mellitus." Master's thesis, Universidade da Beira Interior, 2012. http://hdl.handle.net/10400.6/1121.

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Diabetes mellitus (DM) represents one of the greatest threats to modern global health and its incidence is rapidly rising worldwide. It describes a metabolic disorder characterized by hyperglycaemia resulting from defective insulin secretion, resistance to insulin action, or both. There are two types of DM, type-1 DM (T1DM) and type-2 DM (T2DM), both associated with male infertility. T1DM is associated with insulin deprivation and although the overall in vivo effects in the reproductive function is well known, there is a lack of studies concerning about the insulin control over the physiologic

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7

Ismail, Rubina Siddiqi. "Expression, hormonal regulation and function of Kit ligand, the ligand for thec-Kit receptor, in the rat reproductive system." Thesis, University of Ottawa (Canada), 1998. http://hdl.handle.net/10393/4364.

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Mice having mutations at the Kit and Mast Cell Growth Factor loci suffer from severe development abnormalities in gametogenesis suggesting that the protein products produced at these loci, Kit receptor and kit ligand (KL), serve an essential role in the reproductive system. The purposes of this study were: (1) to identify the expression Kit and KL in the ovary which is the organ in which gametogenesis occurs in the female animal, (2) to determine the expression of Kit and KL in the female reproductive tract, (3) to determine the influence of hormones and growth factors on the expression of Kit

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8

Perrini, C. "EQUINE AND BOVINE MICROVESICLES DERIVED FROM AMNIOTIC PROGENITOR CELLS IN REGENERATIVE AND REPRODUCTIVE TOPICS." Doctoral thesis, Università degli Studi di Milano, 2017. http://hdl.handle.net/2434/490022.

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Durante questo progetto di dottorato sono stati condotti studi per comprendere la capacità delle cellule mesenchimali amniotiche (AMCs) di agire attraverso meccanismi paracrini. La prima fase del disegno sperimentale ha valutato l’efficacia delle AMCs sulla proliferazione delle cellule endometriali (EDCs) in assenza di un contatto cellula-cellula. Le EDCs sono state co-coltivate in un sistema trans-well con le AMCs o sono state coltivate in presenza del loro medium condizionato (CM). In entrambe le condizioni sperimentali è stato osservato un aumento del tasso di proliferazione delle EDCs defi

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9

Uebler, Susanne [Verfasser], Thomas [Akademischer Betreuer] Dresselhaus, and Reinhard [Akademischer Betreuer] Sterner. "Analysis of cell-cell communication during reproductive processes by EA1-like peptides in maize / Susanne Uebler ; Thomas Dresselhaus, Reinhard Sterner." Regensburg : Universitätsbibliothek Regensburg, 2015. http://d-nb.info/1122354932/34.

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10

Uebler, Susanne Verfasser], Thomas [Akademischer Betreuer] [Dresselhaus, and Reinhard [Akademischer Betreuer] Sterner. "Analysis of cell-cell communication during reproductive processes by EA1-like peptides in maize / Susanne Uebler ; Thomas Dresselhaus, Reinhard Sterner." Regensburg : Universitätsbibliothek Regensburg, 2015. http://d-nb.info/1122354932/34.

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11

Lyons, Rachel Ann. "Studies on aspects of cell biology and response to humoral factors of epithelial cells in the human reproductive tract." Thesis, Queen Mary, University of London, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.510918.

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12

Corrigan, Laura. "Regulation and reproductive functions of membrane-bound vesicles secreted by the Drosophila male accessory gland." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:673d46a5-ba88-42d2-9361-51f04d61e01b.

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Membrane-bound vesicle secretion provides a novel intercellular communication mechanism, whose roles and regulation remain poorly characterised, particularly in vivo. I have identified two classes of lipid-containing, vesicle-like structures secreted into seminal fluid by epithelial cells of the Drosophila male accessory gland (AG). Exosomes, one class of membrane-bound vesicle formed inside late endosomal multivesicular bodies, are specifically secreted by secondary cells (SCs). The unusual cell biology of SCs allowed me to develop a powerful new high resolution in vivo system to characterise

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13

Jiwakanon, Jatesada. "The porcine endosalpinx at different reproductive stages : morphology, immune cell infiltration and cytokine expression /." Uppsala : Dept. of Clinical Sciences, Swedish University of Agricultural Sciences, 2009. http://epsilon.slu.se/200912.pdf.

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14

Pellegrino, Giuliana. "Cell neogenesis in the postnatal hypothalamus as a new mechanism of control of the reproductive function." Thesis, Lille 2, 2017. http://www.theses.fr/2017LIL2S042.

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Malgré sa complexité, le cerveau intègre en permanence de nouvelles cellules – à la fois neuronales et gliales – au-delà du développement embryonnaire et ce, tout le long de la vie. La période postnatale est caractérisée par une gliogenèse intense. A l’âge adulte, de nouveaux neurones et cellules gliales sont produits dans des régions restreintes à partir de cellules souches/progénitrices (CSP) localisées dans des niches. Les deux niches de CSP adultes les mieux décrites sont la zone sous-ventriculaire des ventricules latéraux, qui produit de nouveaux interneurones olfactifs, et la zone sous-g

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15

Bonetto, Valentina. "From cell to organism: an overview of responses to simulated hypergravity and microgravity." Doctoral thesis, Università del Piemonte Orientale, 2022. http://hdl.handle.net/11579/144698.

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16

Zabida, Omer Saleh. "The effect of methamphetamine on the blood-testis barrier." University of the Western Cape, 2018. http://hdl.handle.net/11394/6775.

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>Magister Scientiae - MSc<br>Introduction The blood-testis barrier (BTB) is formed by tight junctions between adjacent Sertoli cells. The barrier formed by these tight junction helps to create a specialized environment for spermatogenesis and provide an immunological barrier to protect developing germ cells. Methamphetamine (Meth) is known as neurotoxin however, its effects on the male reproductive system, especially on Sertoli cells and, the BTB are not well established. Therefore, this study aimed to determine the effects of Meth on the TM4 mouse testis Sertoli cell line and on the integrit

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17

Le, Nhung Xuan Hong. "ASSOCIATION OF IMMUNE DYSFUNCTION WITH MICROBIAL DYNAMICS AND ABERRANT ESTROGEN METABOLISM IN REPRODUCTIVE DISORDERS." OpenSIUC, 2021. https://opensiuc.lib.siu.edu/dissertations/1918.

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Chronic inflammation is associated with the pathophysiology of obstetrical disorders (e.g. preterm birth [PTB]) and gynecological diseases (e.g. endometriosis); however, the exact mechanism(s) for these conditions are unknown. Numerous immunological conditions and disease states (e.g. inflammatory bowel disease, Crohn’s disease, systemic lupus erythematomus) also disrupt the microbiome homeostasis by inducing a number of changes in the microbial flora when compared to that of healthy individuals. Furthermore, the gastrointestinal (GI) microbiome is one of the principal regulators of circulatin

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Alhabhbeh, Ammar, Purva Sharma, Mohammad Ali Khan, Koyamangalath Krishnan, and Devapiran Jaishanker. "Adenocarcinoma of Prostate with Small Cell Differentiation Presenting As Refractory Hypokalemia." Digital Commons @ East Tennessee State University, 2020. https://dc.etsu.edu/asrf/2020/presentations/29.

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Prostate cancer is among the most common malignancies in males in the United States and adenocarcinoma accounts for 95% of all malignancies of prostate. Rarely prostate cancer can also present as small cell carcinoma. Pure small cell carcinoma is rare at time of initial diagnosis (<2%) however neuroendocrine differentiation into small cell carcinoma may emerge in men who have had previous treatment with ADT for prostate adenocarcinoma. These tumors, sometimes called treatment-related neuroendocrine prostate cancers or aggressive-variant prostate cancers, are increasingly recognized in the cast

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19

Erasmus, Nicolete. "Investigations on the in vitro effects of aqueous Eurycoma longifolia Jack extract on male reproductive functions." Thesis, University of Western Cape, 2012. http://etd.uwc.ac.za/index.php?module=etd&action=viewtitle&id=gen8Srv25Nme4_2238_1375971626.

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<p>Eurycoma longifolia (Tongkat Ali<br>TA) is a Malaysian shrub used to treat various illnesses including male infertility. Considering that TA is also used to improve male fertility and no report&nbsp<br>regarding its safety has been published, this study investigated the effects of a patented, aqueous TA extract on various sperm and testicular functions. Materials and Methods This study&nbsp<br>encompasses two parts (part 1: on spermatozoa<br>part 2: on TM3-Leydig and TM4-Sertoli cells). Part 1: Semen samples of 27 patients and 13 fertile donors were divided into two groups,&nbsp<br>washed a

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20

Blake, Crystal. "The Effects of Prenatally Administered Phytoestrogens on the Reproductive and Behavioral Development of Long-Evans Rats." BYU ScholarsArchive, 2008. https://scholarsarchive.byu.edu/etd/2364.

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Equol is known to be a selective androgen modulator and has the ability to bind and inhibit 5-alpha dihydrotestosterone (5α-DHT). Equol is also a selective estrogen receptor modulator and is able to bind beta estrogen receptors with high affinity. As estrogen receptors are found in the hypothalamus, pituitary, and gonads, prenatally administered equol could affect the morphological and reproductive development of offspring. To test this hypothesis, during gestational days 14 to 20, forty-two pregnant Long-Evans rats were given one of six treatments: 1) no treatment, 2) injection with dimethyl

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Stefansdottir, Agnes. "Development and use of an in vitro technique to investigate the effect of pharmaceutical agents on female germ cell development." Thesis, University of Edinburgh, 2015. http://hdl.handle.net/1842/16209.

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With meiosis spanning from embryonic development to the end of reproductive life in females, scientists have faced considerable limitations in studying female meiosis and the effects of toxicants on the developing oocyte. Over the last half century, various culture methods have been developed with the aim of studying the mechanisms of early ovary development, as well as for use in reproductive toxicology. However, very few of the established embryonic ovary culture systems have been used to investigate potential reproductive toxicants on the embryonic ovary, in particular when compared with th

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Cheng, Becky. "The Role of the Dosage Compensation Complex as a Pathway for Spiroplasma to Induce Male Lethality in Drosophila melanogaster." Scholarship @ Claremont, 2017. http://scholarship.claremont.edu/cmc_theses/1540.

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Drosophila melanogaster and many other insects harbor intracellular bacterial symbionts that are transmitted vertically from infected host mothers to their offspring. Many of these bacteria alter host reproductive developmental processes in order to increase their transmission success. For example, Spiroplasma, a spirochete that naturally infects D. melanogaster, selectively kills males during mid-embryogenesis while sparing females. Previous studies suggested that Spiroplasma interacts genetically with the male-specific dosage compensation pathway, which causes ~2-fold up-regulation of most g

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23

Gunnarsson, David. "Reproductive toxicology of endocrine disruptors : effects of cadmium, phthalates and phytoestrogens on testicular steroidogenesis." Doctoral thesis, Umeå : Department of Molecular Biology, Umeå University, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1876.

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Somani, Imtiaz Habib. "Gene knockout mouse models of human Tay-Sachs and Sandhoff diseases and their effects on the male reproductive system." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape16/PQDD_0006/MQ29790.pdf.

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Cecere, Thomas E. "Porcine circovirus associated disease: Modulation of the host immune response to PCV2 and PRRSV by regulatory T cells." Diss., Virginia Tech, 2012. http://hdl.handle.net/10919/77098.

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Porcine circovirus associated disease (PCVAD) is currently one of the most economically important diseases facing the global swine industry. Porcine circovirus type 2 (PCV2) is the primary and essential causative agent of PCVAD, but development of clinical disease typically requires co-infection with other swine pathogens such as porcine reproductive and respiratory syndrome virus (PRRSV). The specific mechanisms of co-infection that lead to clinical disease are not fully understood, but immune modulation by the co-infecting viruses is thought to play a critical role. The ability of dendritic

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Swanepoel, Magdaleen. "Embryonic stem cell research and cloning a proposed legislative framework in context of legal status and personhood /." Diss., Pretoria : [s.n.], 2006. http://upetd.up.ac.za/thesis/available/etd-07312007-150150/.

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Fabick, Kimberly Michelle. "The Effects of a Resveratrol Derivative on Regulatory Behaviors and Reproductive Health in Male and Female Long-Evans Rats." BYU ScholarsArchive, 2008. https://scholarsarchive.byu.edu/etd/2839.

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Phytoestrogens are chemicals produced by plants that act like estrogens and have the ability to bind to the mammalian estrogen receptor system. The purpose of this study is to evaluate a new phytoestrogen analog called 4-acetoxy Resveratrol. Resveratrol is a phytoestrogen that has been found in the skin of grapes. Resveratrol has been shown to be able to bind to the estrogen receptors and has a similar molecular structure as estradiol. Resveratrol has been shown to have many positive health benefits such as improving cardiovascular health, serving as a neuroprotective agent, acting as an anti-

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Cao, Qian. "Novel approaches to enhance the protective immune responses of vaccines against Porcine Reproductive and Respiratory Syndrome Virus." Diss., Virginia Tech, 2018. http://hdl.handle.net/10919/92694.

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Since late 1980s, porcine reproductive and respiratory syndrome virus (PRRSV) has emerged as the most economically important swine pathogen affecting pig industries worldwide. Vaccination is the principal means that have been used for prevention of PRRSV infection. However, the currently available vaccines for PRRSV are generally considered as not very effective. One of the major obstacles for developing an effective modified live-attenuated vaccine (MLV) with broad protection is the delayed and insufficient immune responses mounted by PRRSV, and the problem is further exacerbated by the antig

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Pineyro, Pineiro Pablo Enrique. "Novel approaches towards vaccine developments against porcine circovirus type 2 and porcine reproductive and respiratory syndrome virus." Diss., Virginia Tech, 2015. http://hdl.handle.net/10919/77542.

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Porcine circovirus type 2 (PCV2) is the causative agent of porcine circovirus-associated disease (PCVAD). Porcine reproductive and respiratory syndrome (PRRS) is caused by PRRS virus (PRRSV). Both PCV2 and PRRSV have caused devastating diseases in the swine industry worldwide, resulting in immense economic losses. One of the most common co-infections in the swine industry is PCV2 and PRRSV. The aim of this dissertation research is to explore different experimental approaches to develop novel vaccines against the two major pathogens affecting swine production and study the basic mechanisms that

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Crozier, Tamara May. "The effects of reproductive experience on prefrontal cortex dependent learning and memory and pyramidal cell morphology in the rat dam." Thesis, University of British Columbia, 2010. http://hdl.handle.net/2429/29544.

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Pregnancy, parturition, and motherhood, collectively known as reproductive experience, bring about profound and enduring changes in the hormonal, neural, and behavioral profile of the female rat. Much of the research to date investigating the effects of reproductive experience on learning and memory and cellular morphology in the rat dam has focused on the hippocampus. These studies revealed enhancements in spatial working and reference memory as well as alterations in pyramidal cell morphology following reproductive experience. Interestingly, it has long been established that other brain regi

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NOTARSTEFANO, VALENTINA. "Development of new molecular tools for the characterization of human Granulosa cells: new implications for the research on human infertility." Doctoral thesis, Università Politecnica delle Marche, 2018. http://hdl.handle.net/11566/252927.

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Nella routine della riproduzione assistita, la selezione degli ovociti si basa sulle loro caratteristiche morfologiche, nonostante la scarsa correlazione tra tali parametri e la competenza dell’ovocita. Pertanto, la ricerca si sta concentrando sull’identificazione di marker che possano supportare l’attuale metodica di valutazione, in particolare studiando le cellule della Granulosa (GCs), che svolgono compiti fondamentali all’interno del microambiente del follicolo: produzione di estradiolo e progesterone, regolazione dell’avanzamento della meiosi e dell’attività trascrizionale dell’ovoci

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Shaan, Lakshmanappa Yashavanth. "Development and Evaluation of Efficacy of Novel Porcine Reproductive and Respiratory Syndrome (PRRS) Virus Vaccine Candidates in Pigs." The Ohio State University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=osu1532064253191032.

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Madouasse, Aurélien. "An evaluation of milk recording, somatic cell counts and reproductive performance in a large cohort of dairy herds in England and Wales." Thesis, University of Nottingham, 2010. http://eprints.nottingham.ac.uk/11203/.

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Milk recording consists in the regular, usually monthly, collection of a milk sample from all the lactating cows of a dairy herd. A large sample of milk recording data collected in England and Wales between 2004 and 2006 was used in this thesis. A sample of 8,211,988 recordings in 2,128 herds, representing 16 % of the dairy herds in activity in December 2006, were described and analysed. Calvings followed a seasonal pattern with 80 % more calving in September than in May. Milk production was highest in May (26.5 kg) and lowest in October (24.1 kg). Butterfat was stable, close to 4 % from Octob

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Bowers, Hannah Elizabeth, and Jennifer Hall. "THE EFFECTS OF ESTROGEN-INDUCED STROMAL CELL EFFECTORS, OSTEOPONTIN AND VIMENTIN, ON CHLAMYDIA INFECTIONS IN A NON-POLARIZED CELL CULTURE MODEL." Digital Commons @ East Tennessee State University, 2018. https://dc.etsu.edu/asrf/2018/schedule/98.

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Chlamydia is the most reported sexually transmitted infection in the US and is caused by the obligate intracellular bacterium Chlamydia trachomatis. Typically, this presents as a lower genital tract infection (cervicitis or urethritis), but can ascend to the upper genital tract, causing pelvic inflammatory disease, tubal infertility, epididymitis, or ectopic pregnancy. While chlamydia infections can be cured with a single-dose oral antibiotic, repeat infections are common and having multiple chlamydial infections increases a woman’s risk of developing serious chronic conditions. Previous resea

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Lu, Zhigang [Verfasser]. "Towards an in-depth view of the reproductive biology of Schistosoma mansoni : from gonad isolation to sub-transcriptomics and cell culture / Zhigang Lu." Gießen : Universitätsbibliothek, 2016. http://d-nb.info/1082503878/34.

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Mokhtar, Helen. "Characterisation of the T cell response to the porcine reproductive and respiratory syndrome virus and its application towards the development of improved vaccines." Thesis, University of Surrey, 2015. http://epubs.surrey.ac.uk/807548/.

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Porcine reproductive and respiratory syndrome (PRRS) is one of the most important pig diseases worldwide. The causative PRRS virus (PRRSV) is rapidly evolving and there is an urgent need for the development of safer and more efficacious vaccines to improve PRRS control. Immunity to PRRSV is not well understood but there are data suggesting that virus-specific T cell IFN-γ responses play an important role. Therefore, this project focussed on characterising the T cell response PRRSV and applied this knowledge to develop a novel vaccine strategy. The first part of the project aimed to identify th

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Jent, Karen Ingeborg. "Making stem cell niches : an ethnography of regenerative medicine in Scotland and the United States." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/279088.

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This thesis presents the findings from an ethnography of stem cell science based on fieldwork with researchers in two connected laboratories in Scotland and the United States. It explores stem cell scientists' complicated interactions with live stem cell cultures within national projects of translational regenerative medicine. This analysis both draws upon and contributes to the social studies of biomedicine, reproductive studies and science and technology studies. I examine how stem cell scientists, involved in an international research initiative, navigate the challenging landscapes of trans

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Richmond, Owen Benjamin. "Immune modulation mechanisms of porcine circovirus type 2." Diss., Virginia Tech, 2015. http://hdl.handle.net/10919/73766.

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Porcine circovirus associated disease (PCVAD) is an umbrella term for a multitude of diseases and syndromes that have a negative impact on the health and economics of pig production operations throughout the world. Porcine circovirus type 2 is the causative agent of PCVAD; however the presence of PCV2 alone is rarely enough to cause clinical disease. In order for the full development of PCVAD the presence of a co-infecting pathogen is required. The mechanisms by which co-infection leads to disease remain ongoing areas of research, but it is thought that host immune modulations by PCV2 or a co-

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Gaynor, Louise Michelle. "Immunogenetic regulation of Natural Killer cell function in pregnancy." Thesis, University of Cambridge, 2017. https://www.repository.cam.ac.uk/handle/1810/270329.

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Uterine NK (uNK) cells are a distinct subset of NK cells in the decidua of humans and rodents during pregnancy, which are essential for remodelling of the spiral arteries supplying the feto-placental unit. Similarly to peripheral NK cells, uNK cells express Natural Killer receptors (NKRs) that engage MHC class I molecules. Evidence from human genetic association studies suggests that, in the presence of allogeneic cognate paternal MHC class I ligands, inhibitory uterine NKRs are associated with disorders of pregnancy arising from impaired decidual vascular remodelling. Conversely, enhancement

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Dean, Afshan. "Androgens and the masculinisation programming window." Thesis, University of Edinburgh, 2012. http://hdl.handle.net/1842/6516.

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The commonest reproductive disorders of young men (namely low sperm counts, testicular germ cell cancer) may originate in fetal life similar to established disorders (cryptorchidism, hypospadias) that manifest at birth. These disorders are interlinked and may comprise a testicular dysgenesis syndrome (TDS), a concept supported by animal model studies. The latter have identified the likely time-frame within which TDS disorders may be induced, namely within the so-called masculinisation programming window (MPW). During this critical period, sufficient testosterone (androgen) must be produced by

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Liu, Yanhe. "Human oocytes and embryos viewed by time-lapse videography, and the development of an embryo deselection model." Thesis, Edith Cowan University, Research Online, Perth, Western Australia, 2016. https://ro.ecu.edu.au/theses/1787.

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Despite its wide application today, in vitro fertilization (IVF) treatment continues to have relatively low efficacy, largely due to inaccuracy in selecting the best quality embryo(s) from the cohort for transfer. Novel methodologies for improved selection are being developed, and time-lapse observation of human embryos is gaining increasing popularity due to the more detailed morphokinetic information obtained plus uninterrupted culture conditions. The morphokinetic information enables the use of quantitative timings in developmental milestones of embryos and qualitative measures of abnormal

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Taylor, Jacqueline Susan. "The Effect of Pyrethroid Compounds on the Expression of Estrogen Receptors in Mouse Sertoli Cells and Implications for Male Infertility." Thesis, University of Canterbury. Biological Sciences, 2006. http://hdl.handle.net/10092/1482.

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Male fertility is largely controlled by the hypothalamic-pituitary axis, a careful balance between stimulating and suppressing gene expression and the secretion of hormones. The critical factors for male fertility have in the past been thought to be limited to testosterone and the gonadotropins. Estrogen has only recently been demonstrated to be both a crucial requirement for fertility and a cause of infertility. Reports in the early 1990s demonstrated a decrease in mean sperm counts over the last 50 years. A hypothesis for this observation is the increase of xenoestrogens in the environment t

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PERRINO, STEFANIA PIA. "La natura giuridica dell'embrione." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2021. http://hdl.handle.net/10281/314067.

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Il problema qualificatorio dell’embrione costituisce il banco di prova per il civilista dinanzi all’irrompere delle innovazioni in ambito bio-tech. Se lo status del concepito ha rappresentato il terreno di contesa tra le tesi dottrinali più disparate e della giurisprudenza più recente, lo statuto giuridico dell’embrione extra-corporeo costituisce un tema nuovo ma ugualmente controverso. L’elaborato muove da una considerazione generale: non esiste una disciplina unitaria a tutela dell’embrione, fatta eccezione per una serie di laconiche disposizioni normative e sanzioni, penali ed amministrati

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Gawriluk, Thomas R. "Targeted Knockout of Beclin-1 Reveals an Essential Function in Ovary and Testis." UKnowledge, 2014. http://uknowledge.uky.edu/biology_etds/19.

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An estimated 12% of couples worldwide are infertile. The contributing factor is approximately equal between men and women with nearly 25% diagnosed as idiopathic. Despite the increasing numbers of couples seeking assistance from infertility clinics, few molecular mechanisms have been identified for treatment. Autophagy is an evolutionarily conserved cellular process for bulk degradation and recycling of cytosolic components through the lysosome to maintain homeostasis. Several studies have observed increased levels of autophagy during ovarian folliculogenesis and gonadal steroidogenesis; howev

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Le, Ciclé Charles. "Régulation moléculaire et cellulaire des cellules gonadotropes hypophysaires durant le développement embryonnaire et le cycle sexuel femelle." Electronic Thesis or Diss., Université Paris Cité, 2025. http://www.theses.fr/2025UNIP5018.

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Chez les vertébrés, la fonction de reproduction est placée sous le contrôle de l'axe gonadotrope, constitué de l'hypothalamus, de l'hypophyse et des gonades. Sous l'influence majeure de la neurohormone hypothalamique GnRH, les cellules gonadotropes hypophysaires synthétisent et libèrent les deux gonadotropines LH et FSH, qui régulent la gamétogenèse et la stéroïdogenèse des gonades. Mes travaux de thèse ont porté sur l'étude des mécanismes moléculaires et cellulaires régulant les cellules gonadotropes hypophysaires et se déclinent en deux axes principaux. Le premier axe porte sur les mécanisme

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Hadjisavas, Michael. "Induction of mitogenesis and cell-cell adhesion by porcine seminal plasma." Title page, contents and abstract only, 1992. http://web4.library.adelaide.edu.au/theses/09PH/09phh1293.pdf.

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Includes list of publications by the author. Includes bibliographical references (leaves 103-123) Evaluates the nature of the interactions occurring between semen and cells of the uterus that occur following mating in pigs. Describes a novel ability of porcine seminal plasma to induce dose dependent cell-cell adhesion and mitogenesis amongst peripheral blood lymphocytes in vitro.

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Fraga, Cecília Archer de Menezes Castro. "Medicina da produção leiteira : estudos de relação entre o desempenho reprodutivo e as mastites." Master's thesis, Universidade de Lisboa, Faculdade de Medicina Veterinária, 2018. http://hdl.handle.net/10400.5/15046.

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Dissertação de Mestrado Integrado em Medicina Veterinária<br>O impacto das mastites na eficiência reprodutiva dos bovinos leiteiros, tem sido estudado ao longo dos últimos anos, por diversos autores. O objetivo do presente estudo, foi analisar a possível associação causal entre a ocorrência de mastites subclínicas e a alteração do desempenho reprodutivo. Recorrendo a uma base de dados de contraste leiteiro, na qual existiam registos provenientes de 9 explorações nacionais, introduzidos entre 1996 e 2016, procedeu-se à análise da relação da contagem de células somáticas, com o intervalo parto-

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Kieckbusch, Jens. "How do natural killer cells contribute to reproductive success?" Thesis, University of Cambridge, 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.708449.

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Sazzad, TM Shahriar. "An automated approach to identify nongrowing follicles using digitized images of type P63 histopathology ovarian slides." Thesis, Edith Cowan University, Research Online, Perth, Western Australia, 2017. https://ro.ecu.edu.au/theses/2032.

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Many developing countries are still facing challenges with limited access to fertility health services. Women face problems in conceiving due to many factors such as increasing age. In vitro fertilization (IVF) treatments can assist these women but are considered too expensive. Medical pathology laboratories are searching for novel technologies that can improve microscopic slide testing of female ovarian reproductive tissues. Current electronic methods for the assessment of human ovaries are not suitable for analysis of ovarian reproductive tissues. Ultrasound method cannot be used to identify

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Pangestu, Mulyoto 1963. "Drying biological material for use in assisted reproductive technology." Monash University, Institute of Reproduction and Development, 2002. http://arrow.monash.edu.au/hdl/1959.1/7879.

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