Thèses sur le sujet « Receptor, IGF Type 2 »
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O'Reilly, Kathryn Elizabeth. « Integration of mtor and IGF-1 signaling : feedback upregulation of survival pathways in human cancer cells / ». Access full-text from WCMC:, 2007. http://proquest.umi.com/pqdweb?did=1296100571&sid=11&Fmt=2&clientId=8424&RQT=309&VName=PQD.
Texte intégralLuey, Brendan Charles. « Targeting the type 1 IGF receptor in oestrogen-responsive breast cancer ». Thesis, University of Newcastle upon Tyne, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.709848.
Texte intégralGodefroy, Anastasia. « Nouvelle stratégie d'enzymothérapie substitutive ciblant le récepteur du mannose 6-phosphate pour les maladies lysosomales ». Thesis, Montpellier, 2019. http://www.theses.fr/2019MONTT030.
Texte intégralLysosomal diseases form a heterogeneous group of about fifty rare diseases. At present, only 9 lysosomal diseases have a specific treatment, mainly by enzyme replacement therapy but the beneficial effects appear often limited. The lack of targeting for the Mannose 6-Phosphate Receptor (M6PR), responsible for internalization into the lysosomes, would partly explain this moderate efficiency of the therapeutic enzymes. In this context, we have developed an innovative targeting approach based on Mannose 6-Phosphate Synthetic Analogues Functionalized at the Aglycone position (called AMFAs) to address the unmet needs of current treatments.The work of this thesis focuses mainly on Pompe disease which is a myopathy caused by the deficiency of a lysosomal enzyme, Acid Alpha Glucosidase (GAA), responsible for the conversion of glycogen into glucose. In order to improve the targeting of the therapeutic enzyme to lysosomes via the M6PR, we have functionalized the human recombinant GAA (rhGAA) with the AMFAs. Our studies on aged mice model of the adult form of the disease have demonstrated a significant increase of the enzyme internalization and for the first time, the restoration of muscle health and the significant improvement in motor function (article 1). We then investigated the properties of rhGAA-AMFA. We have proved that the effectiveness of rhGAA-AMFA is not only due to a better cell uptake but also to a more complete intracellular processing of the enzyme (article 2). Indeed, our results demonstrated that in myoblasts of patients affected by Pompe disease there is an overexpression of ACP2 and ACP5 acid phosphatases. These phosphatases can destroy the mannose 6-phosphate signal (M6P) naturally present on the enzyme, therefore possibly interrupting its processing into the active form. AMFA, unlike M6P, is insensitive to this degradation and thus ensures the stability of enzyme addressing in vitro, but also in vivo.All together, these results suggest that the grafting of the AMFAs on recombinant enzymes represents a new therapeutic solution for the treatment of Pompe disease and potentially for other lysosomal diseases
Vincent, Karla Kristine. « Transactivation of Beta 2 Adrenergic Receptor by Bradykinin type 2 Receptor via heterodimerization ». Diss., Georgia Institute of Technology, 2009. http://hdl.handle.net/1853/37117.
Texte intégralHower, Amy Elizabeth. « Receptor Functions of the Receptor-Type Protein Tyrosine Phosphatase PTPRO ». Scholarly Repository, 2008. http://scholarlyrepository.miami.edu/oa_dissertations/303.
Texte intégralPatel, Dhaval Subhas. « Analysis of the daf-2 insulin/igf-1 receptor gene in Caenorhabditis elegans ». Thesis, University College London (University of London), 2006. http://discovery.ucl.ac.uk/1445066/.
Texte intégralHatcher-Solis, Candice N. « PHARMACOLOGICAL IMPLICATIONS OF ADENOSINE 2A RECEPTOR- DOPAMINE TYPE 2 RECEPTOR HETEROMERIZATION ». VCU Scholars Compass, 2016. http://scholarscompass.vcu.edu/etd/4458.
Texte intégralPhillips, Timothy Trevor. « A study of metabotropic glutamate receptor type 2 ». Thesis, University of Cambridge, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.624330.
Texte intégralDE, DOMENICO EMANUELA. « Role of type-2 cannabinoid receptor in reproduction ». Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2016. http://hdl.handle.net/2108/202948.
Texte intégralDaws, Michael Rory. « Hormone responsiveness in breast cancer cell growth : the role of the type I IGF receptor ». Thesis, University of Newcastle Upon Tyne, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.284225.
Texte intégralSophocleous, Antonia. « Role of type 2 cannabinoid receptor in bone metabolism ». Thesis, University of Edinburgh, 2009. http://hdl.handle.net/1842/5940.
Texte intégralNetherland, Courtney Denise. « Role of Type 2 Cannabinoid Receptor (CB2) in Atherosclerosis ». Digital Commons @ East Tennessee State University, 2011. https://dc.etsu.edu/etd/1392.
Texte intégralVasilcanu, Radu. « Regulation of insulin-like growth factor-1 receptor expression and signaling / ». Stockholm, 2007. http://diss.kib.ki.se/2007/978-91-7357-244-6/.
Texte intégralStrömberg, Thomas. « The regulation of growth and survival in human multiple myeloma cells by IGF-I receptor signaling / ». Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3586.
Texte intégralKnowlden, Janice M. « Role of insulin-like growth factor-type 1 receptor (IGF-IR) signalling in tamoxifen-resistant breast cancer ». Thesis, Cardiff University, 2008. http://orca.cf.ac.uk/55695/.
Texte intégralLong, Li. « Regulation of tumor cell invasion and metastasis by the type I insulin-like growth factor receptor (IGF-1R) ». Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape11/PQDD_0018/NQ44499.pdf.
Texte intégralMarsh, Andrew. « Characterisation of the type I IGF receptor binding surfaces of insulin-like growth factor 1 using protein engineering ». Thesis, University of Newcastle Upon Tyne, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.245705.
Texte intégralde, Bock Charles Edo St George Clinical School UNSW. « Novel protein interactors of urokinase-type plasminogen activator receptor ». Awarded by:University of New South Wales. St George Clinical School, 2005. http://handle.unsw.edu.au/1959.4/23009.
Texte intégralFulmer, Makenzie. « Role of Cannabinoid Receptor Type 2 (CB2) in Late Stage Atherosclerosis ». Digital Commons @ East Tennessee State University, 2017. https://dc.etsu.edu/etd/3328.
Texte intégralGirnita, Ada. « Targeting insulin-like growth factor-1 receptor in cancer / ». Stockholm, 2004. http://diss.kib.ki.se/2004/91-7140-041-9/.
Texte intégralRodríguez, Eduardo. « Virion- and VAP-receptor recognition in the human adenovirus type 2 system ». Lund : Lund University, 1998. http://catalog.hathitrust.org/api/volumes/oclc/68945080.html.
Texte intégralMoir, Michael. « The Design and Synthesis of Novel Selective Cannabinoid Receptor Type 2 Ligands ». Thesis, The University of Sydney, 2019. https://hdl.handle.net/2123/21946.
Texte intégralMercado-Matos, Jose R. « A Mechanistic Investigation of Insulin Receptor Substrate 2 Function in Breast Cancer Progression ». eScholarship@UMMS, 2017. http://escholarship.umassmed.edu/gsbs_diss/918.
Texte intégralVasilcanu, Daiana. « IGF-1R inhibition : a tool for functional studies of insulin-like growth factors family in malignant cells / ». Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-643-3/.
Texte intégralEhrnborg, Christer. « Growth hormone in athletes / ». Göteborg : Department of Internal Medicine, Institute of Medicine, The Sahlgrenska Academy at Göteborg University, 2007. http://hdl.handle.net/2077/4709.
Texte intégralStumpf, Alexander [Verfasser]. « Cannabinoid type 2 receptor-mediated cell type-specific self-inhibition in hippocampal and cortical neurons / Alexander Stumpf ». Berlin : Freie Universität Berlin, 2019. http://d-nb.info/1190087871/34.
Texte intégralColón, Eugenia. « Autocrine and paracrine regulation of Leydig cell survival in the postnatal testis / ». Stockholm : Karolinska institutet, 2007. http://diss.kib.ki.se/2007/978-91-7357-275-0/.
Texte intégralMetcalfe, Beverly Lynn. « Defining the role of the angiotensin ii type 2 receptor in cardiovascular disease ». [Gainesville, Fla.] : University of Florida, 2004. http://wwwlib.umi.com/cr/ufl/fullcit?p3136977.
Texte intégralTypescript. Title from title page of source document. Document formatted into pages; contains 136 pages. Includes Vita. Includes bibliographical references.
Bhandari, R. N. B. « Characterization of a cell adhesion receptor on rat lung alveolar type 2 cells ». Thesis, Imperial College London, 1988. http://hdl.handle.net/10044/1/46962.
Texte intégralChu, Yatson. « Herpes simplex virus type 2 regulates the IFN-gamma receptor expression and function ». Thesis, University of Ottawa (Canada), 2003. http://hdl.handle.net/10393/26460.
Texte intégralFranklin, Zara Jane. « Evaluation and characterisation of novel glucagon receptor antagonists for type 2 diabetes therapy ». Thesis, University of Ulster, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.588499.
Texte intégralMa, Ching-man, et 馬靜雯. « Molecular epidemiology and characterization of the receptor binding ofporcine circovirus type 2 (PCV2) ». Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2006. http://hub.hku.hk/bib/B38227204.
Texte intégralLi, K. « Interactions of complement receptor type 2 with C3d and factor H with C3u ». Thesis, University College London (University of London), 2010. http://discovery.ucl.ac.uk/769696/.
Texte intégralSouto, Maior Mourão Sá D. « Characterisation of the C-type lectin receptor CLEC-2 : expression, ligands and functions ». Thesis, University College London (University of London), 2011. http://discovery.ucl.ac.uk/1302407/.
Texte intégralSeta, Koichi. « Study on mechanisms for angiotensin 2 type 1 receptor-mediated tyrosine kinase activation ». Kyoto University, 2008. http://hdl.handle.net/2433/135926.
Texte intégralGoto, Masahisa. « Growth-Dependent Induction of Angiotensin II Type 2 Receptor in Rat Mesangial Cells ». Kyoto University, 2001. http://hdl.handle.net/2433/150550.
Texte intégralSehat, Bita. « SUMO and ubiquitin ; the yin and yang of IGF-1R function / ». Stockholm, 2007. http://diss.kib.ki.se/2007/978-91-7357-360-3/.
Texte intégralRosengren, Linda. « Targeting the GH/IGF-1 axis with novel, small molecule inhibitors / ». Stockholm : Karolinska institutet, 2007. http://diss.kib.ki.se/2007/978-91-7357-346-7/.
Texte intégralBode-Rhoads, Michelle Lynn. « Regulation of the growth hormone receptor, insulin-like growth factor (IGF) I and IGF binding protein 2 in reproductive tissues of dairy cattle during lactation and associated effects on fertility ». free to MU campus, to others for purchase, 2004. http://wwwlib.umi.com/cr/mo/fullcit?p3164490.
Texte intégralDigirolamo, Douglas J. « Growth hormone signaling and action in osteoblasts ». Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2008. https://www.mhsl.uab.edu/dt/2009r/digirolamo.pdf.
Texte intégralBoulle, Nathalie. « Analyse du système des insulin-like growth factors (IGF) et du fibroblast growth factor-2 (FGF-2) dans la tumorigenèse corticosurrenalienne ». Paris 11, 2000. http://www.theses.fr/2000PA11T006.
Texte intégralLn adrenocortical tumors, malignant phenotype is associated with abnormalities at the 11p15 locus and overexpression of the IGF-11 gene. Here, we show that IGF-11 mRNA is efficiently translated and that malignant adrenocortical tumors contain large amounts of IGF-11 protein, mainly in its prohormone form. The same tumors exhibit a high content in IGFBP-2 protein, an IGFBP being frequently expressed in tumor cells. The H295R cell line, which is derived from a human adrenal carcinoma, express high levels of both IGF-11 and IGFBP-2 and represents a suitable in vitro model to study adrenocortical tumorigenesis. Using this cell line, we could demonstrate that IGF-11 is involved in the proliferation of adrenocortical tumor cells, after binding to the type 1 IGF receptor. The interest of plasma IGFBP-2 as a marker for adrenocortical carcinoma was evaluated. Our results show that high levels of IGFBP-2 are specifically detected in the plasma of patients with malignant adrenocortical tumors. However, the increase in IGFBP-2 levels occur at a late stage of tumor progression (metastatic stage). This indicates a poor sensitivity for plasma IGFBP-2, which may limit its interest as a tumor marker. We also studied the effects of FGF-2 on adrenocortical tumor cells. Our results indicate that FGF-2 is mitogenic for H295R cells, although it inhibits the expression of both IGF-11 and IGFBP-2 by these cells. The inhibition of IGFBP-2 expression occur at the transcriptional levels. Ln contrast, FGF-2 inhibits the secretion and the last steps of maturation of the IGF-11 precursor. Altogether, these results suggest that in malignant adrenocortical tumors, various factors may modulate the expression (FGF-2) or the effects (IGFBP-2) of IGF-11 on adrenocortical tumor cells
Adachi, Yuichiro. « Angiotensin 2 type 2 receptor deficiency exacerbates heart failure and reduces survival after acute myocardial infarction in mice ». Kyoto University, 2006. http://hdl.handle.net/2433/144310.
Texte intégralRuch, Claudia. « Structure / function analysis of the extracellular domain of vascular endothelial growth factor receptor-2 (VEGFR-2) / ». Zürich : ETH/PSI, 2007. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=17030.
Texte intégralMa, Ching-man. « Molecular epidemiology and characterization of the receptor binding of porcine circovirus type 2 (PCV2) ». Click to view the E-thesis via HKUTO, 2006. http://sunzi.lib.hku.hk/hkuto/record/B38227204.
Texte intégralSurovy, André Martin. « Toll like Receptor 2 is highly expressed in lesions of Acne Inversa and colocalizes with C-type Lectin Receptor expression / ». Bern : [s.n.], 2007. http://www.ub.unibe.ch/content/bibliotheken_sammlungen/sondersammlungen/dissen_bestellformular/index_ger.html.
Texte intégralPickel, Lara Michelle. « Study of the role of the Angiotensin II (Ang II) type 2 receptor (AT[subscript]2) in lung tumorigenesis ». Thesis, Manhattan, Kan. : Kansas State University, 2008. http://hdl.handle.net/2097/788.
Texte intégralCosaceanu, Daria. « The use of IGF-IR inhibitors in cancer therapy - a potential approach for sensitizing tumor cells to ionizing radiation / ». Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-911-4/.
Texte intégralRibeiro, Tamaya Castro. « Análise da expressão e do silenciamento do receptor tipo 1 do fator de crescimento semelhante à insulina em tumores adrenocorticais humanos ». Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/5/5166/tde-16032015-161040/.
Texte intégralIntroduction: The insulin-like growth factor (IGF) system plays a key role in normal cell growth and development. IGF1R overexpression has been demonstrated in several tumors suggesting that its expression is a prerequisite for cell transformation. We demonstrated IGF1R overexpression in pediatric adrenocortical tumors. Objectives: To induce IGF1R silencing by siRNA in a human adrenocortical cell line NCI H295R and evaluate its effects on cell proliferation and apoptosis. Additionally, evaluate the expression of IGF-1R protein and microRNAs related to its transcription in human adrenocortical tumors. Patients and methods: The human adrenocortical tumor cell line NCI H295R was cultured and treated with 2 specific IGF1R siRNA. All experiments were carried out in four groups: (1) untreated NCI H295R cells, (2) NCI H295R cells transfected with specific IGF1R siRNA # 1, (3) NCI H295R cells transfected with specific IGF1R siRNA # 2 and (4) NCI H295R cells transfected with a negative control. IGF-1R gene and protein expression was determined by the techniques of real-time PCR and Western blot, respectively. We assessed the effects of IGF-1R silencing on cell proliferation and apoptosis. Moreover, 202 patients with adrenocortical tumors were selected for the study of IGF-1R protein expression by immunohistochemistry. In the analysis of microRNAs that are related to IGF1R (miR-100, 375, 145 e 126) by real time PCR, 32 out 202 patients were selected. Results: IGF-1R levels were significantly decreased in cells that were treated with IGF-1R siRNA # 1 and siRNA # 2. The relative values of IGF1R mRNA decreased approximately 50% and Western blot analysis revealed a 30% of reduction in IGF-1R protein. Downregulation of this gene was accompanied by a reduction in 40% of cell growth in vitro and an increase in 45% of apoptosis. The analysis of microRNAs demonstrated that IGF1R expression is not correlated with the expression of these small RNAs. Additionally, the analysis of IGF-1R protein expression in human adrenocortical tumors revealed that strong expression (20%) of IGF-1R was more common in adult carcinomas. Moreover, the nuclear IGF-1R was more frequent in carcinomas diagnosed in adults (19%) when compared to adenomas. Conclusions: These data demonstrate the importance of IGF-1R in tumorigenic pathways of malignant neoplasms of the adrenocortical gland. IGF-1R silencing could inhibit tumor growth in vitro by reducing cell proliferation and increasing apoptosis in a cell line of human adrenocortical carcinoma. Furthermore, nuclear IGF-1R expression was more frequent in carcinomas diagnosed in adults, suggesting that IGF-1R may be a biological marker of this neoplasia
Girnita, Leonard. « Growth factor pathways in human cancer : functional and therapeutic implications / ». Stockholm, 2002. http://diss.kib.ki.se/2002/91-7349-307-4.
Texte intégralXie, Yuntao. « The biological role and clinical impact of SYT-SSX fusion gene and IGF-1R in synovial sarcoma / ». Stockholm, 2002. http://diss.kib.ki.se/2002/91-628-5298-1.
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