Littérature scientifique sur le sujet « Re-différenciation »
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Articles de revues sur le sujet "Re-différenciation"
Braverman, Louis, et Aurore Loretti. « La santé face aux inégalités et aux discriminations ». Emulations - Revue de sciences sociales, no 35-36 (30 décembre 2020) : 1–19. http://dx.doi.org/10.14428/emulations.03536.01.
Texte intégralBeauregard, Caroline, Garine Papazian-Zohrabian et Cécile Rousseau. « Mouvement des frontières identitaires dans les dessins d’élèves immigrants ». Alterstice 7, no 2 (10 octobre 2018) : 105–16. http://dx.doi.org/10.7202/1052573ar.
Texte intégralRodrigues Durães, Bruno José. « O TRABALHO INFORMAL DE RUA RECONFIGURADO : sua função como agente da acumulação ». Caderno CRH 33 (19 décembre 2020) : 020023. http://dx.doi.org/10.9771/ccrh.v33i0.28167.
Texte intégralHorton, David. « Social deixis in the translation of dramatic discourse ». Babel. Revue internationale de la traduction / International Journal of Translation 45, no 1 (23 juillet 1999) : 53–73. http://dx.doi.org/10.1075/babel.45.1.05hor.
Texte intégralMaulini, Olivier, et Cynthia Mugnier. « Entre éthique de l’intégration et pratiques de la différenciation : (re)penser l’organisation du travail scolaire ? » Recherches en éducation, Hors série n°4 (1 juin 2012). http://dx.doi.org/10.4000/ree.9004.
Texte intégralThèses sur le sujet "Re-différenciation"
Marie, Corentine. « The role of Chd7 & ; Chd8 chromatin remodelers in oligodendrogenesis and (re)myelination ». Thesis, Paris 6, 2017. http://www.theses.fr/2017PA066365/document.
Texte intégralOligodendrocytes (OLs) are myelin-forming cells of the central nervous system wrapping axons and allowing the saltatory conduction of action potentials. In Multiple sclerosis (MS), myelin sheath is destroyed and effective remyelination by oligodendrocyte precursor cells (OPCs) diminishes with disease progression. Therefore, a better understanding of the mechanisms controlling OPC generation and differentiation is essential to develop efficient remyelinating therapies. Oligodendrogenesis, involving the steps of OPC generation, OPC differentiation and maturation of OLs, is a process controlled by specific transcription factors including Ascl1, Olig2 and Sox10 but the mechanisms involved are poorly understood. As it is known that chromatin remodelers are regulatory factors necessary in the formation of the promoter-enhancer loop prior to transcription, we focused our study on Chd7 (Chromodomain-Helicase-DNA-Binding 7), a member of the CHD protein family. In a first study, we showed that Chd7 is highly enriched in the oligodendroglial lineage cells with a peak of expression during OL differentiation and that Chd7 OPC-conditional deletion impairs OL differentiation during (re)myelination. In a second study, we used unbiased genome wide technics in purified OPCs to study Chd7 regulation of genes involved in OPC differentiation, proliferation and survival. To this aim, we have generated OPC-specific inducible Chd7 knock-out (Chd7-iKO) and analyse the transcriptome (RNA-seq) of purified OPCs from P7 mouse cortices compared to control littermates. We found that Chd7 promote the expression genes involved in OPC differentiation and myelination and inhibits apoptosis, without affecting OPC proliferation. Furthermore, we investigated Chd8, a paralog of Chd7, showing that it is expressed in the oligodendroglial lineage with a peak of expression in differentiating oligodendrocytes, similar to Chd7. Genome wide binding (ChIP-seq) profiling for Chd7 and Chd8 indicate that these two chromatin remodelers bind to common genes related to OPC differentiation, survival and proliferation. Integrating these datasets with other key transcriptional regulators of oligodendrogenesis (Olig2, Ascl1 & Sox10), we have built a model accounting for the time-controlled regulate expression of genes involved in each step of OL differentiation
Radom, Mickaëlle. « Rôle de la NADPH oxydase 4 (NOX4) dans la dédifférenciation des cellules tumorales thyroïdiennes porteuses de la mutation BRAFV600E ». Electronic Thesis or Diss., université Paris-Saclay, 2024. http://www.theses.fr/2024UPASL012.
Texte intégralThe radioiodine therapy (RAI) constitutes the main treatment for differentiated thyroid cancer (DTC). This metabolic radiotherapy is based on the expression at thyroid cell basal membrane of the iodine transporter (NIS) encoded by SLC5A5 gene. BRAFV600E oncogene driver mutation is present in 40 to 60% of DTC. Locally advanced and metastatic papillary thyroid cancer (PTC) harboring BRAFV600E mutation have poor prognosis. BRAFV600E oncogene is a strong activator of MAPK signaling leading to a dedifferentiation process, which is associated with SLC5A5 gene repression and radioiodine therapy refractoriness. The RAI uptake constitutes a major challenge for treatment of patients and in this sense a new therapeutic approach consists of thyroid cell redifferentiation strategy. Our previous studies showed that BRAFV600E controls the NADPH oxidase (NOX4) expression and NOX4- derived ROS repress SLC5A5 gene. NOX4 inhibition reinduces NIS expression and the reversibility suggests a contribution to an epigenetic mechanism. The objective of the thesis was to determine the molecular and mechanistic events induced by NOX4-derived ROS that contribute to the repression of genes involved in differentiation process and in the efficiency of metabolic radiotherapy. Our results showed that NOX4 generates specific oxidative damage to DNA, which promotes the retention of epigenetic actors such as DNMTs through interaction with DNA repair proteins, thereby disrupting the DNA binding of thyroid differentiation transcription factors, PAX8 and NKX.2.1, and preventing gene transcription for prolonged periods. We also demonstrated an effect of BRAF/MEK inhibitors used clinically in NOX4- dependant epigenetic mechanism and a clinical interest of NOX4 inhibition in addition to BRAF/MEK inhibition in thyroid differentiation gene reinduction