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Littérature scientifique sur le sujet « Quantitative magnetization transfer-MRI »

Auteur : Grafiati

Publié le 9 mars 2023

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Articles de revues sur le sujet "Quantitative magnetization transfer-MRI"

A.G. Teixeira, Rui Pedro, Shaihan J. Malik et Joseph V. Hajnal. « Fast quantitative MRI using controlled saturation magnetization transfer ». Magnetic Resonance in Medicine 81, n^o 2 (14 septembre 2018) : 907–20. http://dx.doi.org/10.1002/mrm.27442.

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Cercignani, Mara, et Daniel C. Alexander. « Optimal acquisition schemes for in vivo quantitative magnetization transfer MRI ». Magnetic Resonance in Medicine 56, n^o 4 (10 août 2006) : 803–10. http://dx.doi.org/10.1002/mrm.21003.

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Rovaris, Marco, Elda Judica, Jaume Sastre-Garriga, Alex Rovira, Maria Pia Sormani, Beatrice Benedetti, Tijmen Korteweg et al. « Large-scale, multicentre, quantitative MRI study of brain and cord damage in primary progressive multiple sclerosis ». Multiple Sclerosis Journal 14, n^o 4 (21 janvier 2008) : 455–64. http://dx.doi.org/10.1177/1352458507085129.

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Although the mechanisms underlying the accumulation of disability in primary progressive (PP) multiple sclerosis (MS) are still unclear, a major role seems to be played by `occult' tissue damage. We investigated whether conventional and magnetization transfer (MT) MRI may provide complementary information for the assessment of PPMS severity. Conventional and MT MRI scans from 226 PPMS patients and 84 healthy controls were collected for centralized analysis. The expanded disability status scale (EDSS) score was rated at the time of MRI acquisition. T2 lesion volume, normalized brain volume (NBV) and cervical cord cross-sectional area (CSA) were measured. Magnetization transfer ratio (MTR) histograms from whole brain tissue, normal-appearing white matter and grey matter (NAGM) were also obtained. Mean NBV, CSA and MTR histogram-derived metrics showed significant inter-centre heterogeneity. After correcting for the acquisition centre, pooled average MTR and histogram peak height values were different between PPMS patients and controls for all tissue classes ( P-values between 0.03 and 0.0001). More severe brain and cord atrophy and MT MRI-detectable NAGM damage were found in patients who required walking aids than in those who did not ( P-values: 0.03, 0.001 and 0.016). A composite score of NBV, CSA, whole brain and NAGM MTR histogram peak height z-scores was correlated with patients' EDSS ( r = 0.37, P 0.001). Magnetization transfer MRI might provide information complementary to that given by conventional MRI when assessing PPMS severity. Sequence-related variability of measurements makes the standardization of MT MRI acquisition essential for the design of multicentre studies. Multiple Sclerosis 2008; 14: 455—464. http://msj.sagepub.com

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Sled, John G., et G. Bruce Pike. « Quantitative Interpretation of Magnetization Transfer in Spoiled Gradient Echo MRI Sequences ». Journal of Magnetic Resonance 145, n^o 1 (juillet 2000) : 24–36. http://dx.doi.org/10.1006/jmre.2000.2059.

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Li, Weiguo, Zhuoli Zhang, Jodi Nicolai, Guang-Yu Yang, Reed A. Omary et Andrew C. Larson. « Quantitative magnetization transfer MRI of desmoplasia in pancreatic ductal adenocarcinoma xenografts ». NMR in Biomedicine 26, n^o 12 (12 août 2013) : 1688–95. http://dx.doi.org/10.1002/nbm.3004.

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Alcaide-Leon, Paula, Kateryna Cybulsky, Stephanie Sankar, Courtney Casserly, General Leung, Marika Hohol, Daniel Selchen, Xavier Montalban, Aditya Bharatha et Jiwon Oh. « Quantitative spinal cord MRI in radiologically isolated syndrome ». Neurology - Neuroimmunology Neuroinflammation 5, n^o 2 (18 janvier 2018) : e436. http://dx.doi.org/10.1212/nxi.0000000000000436.

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ObjectivesTo assess whether quantitative spinal cord MRI (SC-MRI) measures, including atrophy, and diffusion tensor imaging (DTI) and magnetization transfer imaging metrics were different in radiologically isolated syndrome (RIS) vs healthy controls (HCs).MethodsTwenty-four participants with RIS and 14 HCs underwent cervical SC-MRI on a 3T magnet. Manually segmented regions of interest circumscribing the spinal cord cross-sectional area (SC-CSA) between C3 and C4 were used to extract SC-CSA, fractional anisotropy, mean, perpendicular, and parallel diffusivity (MD, λ⊥, and λ||) and magnetization transfer ratio (MTR). Spinal cord (SC) lesions, SC gray matter (GM), and SC white matter (WM) areas were also manually segmented. Multivariable linear regression was performed to evaluate differences in SC-MRI measures in RIS vs HCs, while controlling for age and sex.ResultsIn this cross-sectional study of participants with RIS, 71% had lesions in the cervical SC. Of quantitative SC-MRI metrics, spinal cord MTR showed a trend toward being lower in RIS vs HCs (p = 0.06), and there was already evidence of brain atrophy (p = 0.05). There were no significant differences in SC-DTI metrics, GM, WM, or CSA between RIS and HCs.ConclusionThe SC demonstrates minimal microstructural changes suggestive of demyelination and inflammation in RIS. These findings are in contrast to established MS and raise the possibility that the SC may play an important role in triggering clinical symptomatology in MS. Prospective follow-up of this cohort will provide additional insights into the role the SC plays in the complex sequence of events related to MS disease initiation and progression.

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Adler, J., P. Schmiedlin-Ren, P. Higgins, T. Verrot et E. Zimmermann. « Magnetization transfer MRI for quantitative assessment of intestinal fibrosis in Crohnʼs disease ». Inflammatory Bowel Diseases 13, supplement (mai 2007) : 648–49. http://dx.doi.org/10.1097/00054725-200705001-00020.

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Adler, J., P. Schmiedlin-Ren, P. Higgins, T. Verrot et E. Zimmermann. « Magnetization transfer MRI for quantitative assessment of intestinal fibrosis in Crohnʼs disease ». Inflammatory Bowel Diseases 13 (mai 2007) : 648. http://dx.doi.org/10.1097/00054725-200705005-00020.

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Smith, Alex K., Richard D. Dortch, Lindsey M. Dethrage et Seth A. Smith. « Rapid, high-resolution quantitative magnetization transfer MRI of the human spinal cord ». NeuroImage 95 (juillet 2014) : 106–16. http://dx.doi.org/10.1016/j.neuroimage.2014.03.005.

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Fatemi, Ali, Mary Ann Wilson, Andre W. Phillips, Michael T. McMahon, Jiangyang Zhang, Seth A. Smith, Edwin J. Arauz et al. « In vivo Magnetization Transfer MRI Shows Dysmyelination in an Ischemic Mouse Model of Periventricular Leukomalacia ». Journal of Cerebral Blood Flow & ; Metabolism 31, n^o 10 (4 mai 2011) : 2009–18. http://dx.doi.org/10.1038/jcbfm.2011.68.

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Periventricular leukomalacia, PVL, is the leading cause of cerebral palsy in prematurely born infants, and therefore more effective interventions are required. The objective of this study was to develop an ischemic injury model of PVL in mice and to determine the feasibility of in vivo magnetization transfer (MT) magnetic resonance imaging (MRI) as a potential monitoring tool for the evaluation of disease severity and experimental therapeutics. Neonatal CD-1 mice underwent unilateral carotid artery ligation on postnatal day 5 (P5); at P60, in vivo T2-weighted (T2w) and MT-MRI were performed and correlated with postmortem histopathology. In vivo T2w MRI showed thinning of the right corpus callosum, but no significant changes in hippocampal and hemispheric volumes. Magnetization transfer MRI revealed significant white matter abnormalities in the bilateral corpus callosum and internal capsule. These quantitative MT-MRI changes correlated highly with postmortem findings of reduced myelin basic protein in bilateral white matter tracts. Ventriculomegaly and persistent astrogliosis were observed on the ligated side, along with evidence of axonopathy and fewer oligodendrocytes in the corpus callosum. We present an ischemia-induced mouse model of PVL, which has pathologic abnormalities resembling autopsy reports in infants with PVL. We further validate in vivo MRI techniques as quantitative monitoring tools that highly correlate with postmortem histopathology.

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Thèses sur le sujet "Quantitative magnetization transfer-MRI"

Sled, John G. « Quantitative imaging of magnetization transfer parameters in vivo using MRI ». Thesis, McGill University, 2000. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=37841.

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Magnetization transfer (MT) imaging is a relatively new magnetic resonance imaging (MRI) technique that generates contrast dependent upon the phenomenon of magnetization exchange between semi-solid macromolecular protons and water protons. This technique has the ability to indirectly image semi-solids, such as protein matrices and cell membranes, whose magnetization dies away too quickly to be imaged directly. Preliminary in vitro and in vivo results suggest that MT quantification may allow improved characterization of the pathologically heterogeneous lesions of multiple sclerosis (MS) by providing a measure of demyelination. However, MT imaging, as currently applied, is only a semi-quantitative technique that reflects a complex combination of tissue and experimental parameters in addition to MT.
In this thesis a novel quantitative imaging technique is described that yields all of the observable properties of the binary spin bath model for MT. Based on a new model of the steady-state behavior of the magnetization during a pulsed MT weighted imaging sequence, as well as new methodological developments in MRI relaxometry, this approach yields parametric images of the fractional size of the restricted pool, the magnetization exchange rate, the T2 of the restricted pool and the relaxation times in the free pool. Validated experimentally on agar gels and samples of uncooked beef, the method is demonstrated in studies of two normal subjects and a patient with multiple sclerosis.

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Shah, Tejas Jatin. « Rapid and Quantitative MRI of Chemical Exchange and Magnetization Transfer ». Case Western Reserve University School of Graduate Studies / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=case1279943930.

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Clark, Daniel James. « Chemical Exchange Saturation Transfer and Quantitative MRI Methods : Applications for Osteoarthritis and Cartilage Injury ». The Ohio State University, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=osu1431016691.

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TURATI, LAURA. « Quantitative Magnetization Transfer imaging for in vivo analysis of myelin content in experimental model of demyelination ». Doctoral thesis, Università degli Studi di Milano-Bicocca, 2014. http://hdl.handle.net/10281/55300.

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La demielinizzazione è un processo patologico in cui le guaine mieliniche, che rivestono gli assoni, sono danneggiate. La demielinizzazione del sistema nervoso centrale (SNC) è la conseguenza di un insulto diretto o indiretto agli oligodendrociti, cellule del SNC deputate alla produzione ed al mantenimento delle guaine mieliniche. La remielinizzazione è invece l’evento naturale che dovrebbe ripristinare la conduzione dell’impulso elettrico assonale e risolvere i deficit funzionali. Nella sclerosi multipla (SM) la perdita di mielina, in particolare in prossimità delle regioni internodali, è associata al blocco della conduzione nervosa e non è compensata da adeguata remielinizzazione. Lo sviluppo di terapie in grado di controllare il processo di demielinizzazione e la valutazione della loro efficacia è in parte complicato dalla difficoltà di valutare in modo non invasivo lo stato della mielina. Nel presente studio, la tecnica ‘quantitative magnetization transfer-MRI’ (qMT-MRI) è stata utilizzata per valutare il grado di de/remielinizzazione nel modello murino sperimentale indotto da cuprizone, un agente chelante del rame a cui gli oligodendrociti sono particolarmente sensibili. L’ipotesi di base dello studio è che il valore di ‘macromolecular pool size ratio’ (F) sia una stima accurata della densità mielinica in vivo; la correlazione tra analisi in MRI ed istologia è stata finora confermata prevalentemente su campioni di SNC ex vivo. Le corrispondenze tra il parametro F, che risulta dall’interpolazione di differenti misure qMT-MRI, con l’intensità di colorazione per fibre mieliniche (mediante Black Gold II), e con l’intensità di immunofluorescenza per la proteina basica della mielina e per la proteina citoscheletrica neuronale beta-tubulina sono state valutate a differenti time-points, in uno studio sperimentale longitudinale. Topi C57BL/6 e SJL/J sono stati trattati con cuprizone al fine di causare perdita selettiva della mielina, che è seguita da spontanea remielinizzazione dopo la sospensione del trattamento. I risultati hanno confermato una correlazione statisticamente significativa delle misure di F con il contenuto di mielina, e dimostrano l’applicabilità di analisi MRI in vivo nei modelli sperimentali di SM, come strumento per il monitoraggio dello stato della mielina.
Demyelination is a pathological process in which myelin sheaths, around axons, are damaged. Demyelination of the central nervous system (CNS) is the consequence of a direct or indirect insult to oligodendrocytes, specific cells in the CNS that produce and sustain the myelin sheaths. Instead, remyelination is a spontaneous event in which myelin sheaths are restored in demyelinated nerve regions, thus recovering saltatory signal conduction and resolving functional deficits. In multiple sclerosis (MS), the loss of myelin particularly in internode regions is associated with block of nerve conduction and it is not compensated by adequate remyelination. The development of therapies able to control the process of demyelination and the evaluation of their effectiveness is partially complicated by the difficulty in assessing myelin status non-invasively. In the present study, 'quantitative magnetization transfer MRI' (qMT-MRI) technique is used to assess the degree of de/remyelination in an experimental murine model induced by cuprizone, a copper chelator to which oligodendrocytes are preferentially susceptible. The basic hypothesis of the study is that the in vivo measurement of ‘macromolecular pool size ratio’ (F) could be an accurate estimation of myelin density; the correlation between MRI and histology analysis has so far been confirmed mainly on ex vivo CNS samples. The correspondences between the parameter F, which is interpolated from qMT-MRI measures, with the intensity of staining for myelinated fibers (using Black Gold II), and with the intensity of myelin basic protein and neuronal cytoscheletric protein beta-tubulin immunofluorescences were evaluated at different time-points, in an experimental longitudinal study. C57BL/6 and SJL/J mice were fed with cuprizone in order to cause selective myelin loss, which is followed by spontaneous remyelination upon treatment suspension. The results confirmed a statistically significant correlation between F measures and myelin content, and demonstrated the in vivo applicability of MRI analysis to experimental models of MS, as a tool for monitoring myelin status.

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Pantel, Pia Marie. « Innovative MRT-Kontraste zur in-vivo-Differenzierung von Patienten mit typischem idiopathischen Parkinson und atypischen Parkinsonsyndromen ». Doctoral thesis, 2013. http://hdl.handle.net/11858/00-1735-0000-0022-60A1-A.

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HINTERGRUND/ ZIELSETZUNG: Vom idiopathischen Parkinsonsyndrom (IPS) können so genannte „atypische“ Parkinsonsyndrome (APS) mit einem Anteil von ca. 20% bezogen auf die Gesamtinzidenz unterschieden werden. Neben zusätzlichen Krankheitssymptomen und einem progredienteren Verlauf zeichnen sie sich durch eine schlechtere Prognose aus, die häufig auf einem Nichtansprechen auf eine dopaminerge Therapie beruht. Eine frühzeitige, korrekte Diagnose ist daher sehr entscheidend, aber im Einzelfall auch für Spezialisten äußerst schwierig. Trotz anerkannter klinischer Diagnosekriterien gibt es besonders im Frühstadium eine hohe Rate an Fehldiagnosen. Das zur Zeit vorherrschende Verfahren in der bildgebenden Diagnostik ist die Magnetresonanztomographie, wobei die konventionelle, qualitative MRT bislang keine zufriedenstellenden Ergebnisse bezüglich ihrer Spezifität und Sensitivität gezeigt hat. Die vorliegende Arbeit untersucht in einer direkten Vergleichsstudie das differenzialdiagnostische Potential der sogenannten „erweiterten“ quantitativen MRT-Verfahren. MATERIAL UND METHODEN: Ein Gesamtkollektiv von insgesamt 44 Probanden (IPS/ APS/ gesunde Kontrollen) durchlief ein umfassendes quantitatives MRT- Protokoll (R1/R2(*)-, DTI-, MTR- Mapping) um in manuell bilateral markierten, definierten Regionen (ROIs) in den Basalganglienkernen quantitative Parameter zu erheben. ERGEBNISSE: Die beste hochsignifikante Trennung der MSA-P- Patienten sowohl von IPS- Patienten (p = 0,001) als auch von Kontrollen (p = 0,004) konnte anhand des R2 * - Mappings im Putamen erreicht werden. Es zeigte sich eine Vorhersagekraft AUC von > / = 0,96 mit einer Sensitivität von 77,8 % (bei einer Spezifität von 100 %). Dies bestätigt die große Bedeutung der Eisensensitivität des R2*-Mappings bei der Identifizierung von MSA-P- Patienten. Auch anhand des MTR-Mappings konnte eine MSA-P anhand der putaminalen (p = 0,005) und nigralen (p = 0,003) Signalveränderungen signifikant vorhergesagt werden. Die beste signifikante Abgrenzung der PSP- Patienten von den Kontrollen gelang anhand der DTI- Messungen in der Substantia nigra (p = 0,001) sowie im Globus pallidus (p = 0,004). Für die diagnostische Vorhersage eines IPS konnten keine nutzbaren Signalunterschiede festgestellt werden. Insbesondere in der Substantia nigra zeigten sich gegenüber Kontrollen keine signifikanten Gruppenunterschiede. FAZIT: Unter den angewandten MRT- Verfahren zeigt das R2*-Mapping die beste Vorhersagekraft zur Differenzierung der MSA von IPS- Patienten und das DTI- Mapping zur Identifizierung der PSP- Patienten. Das Besondere unseres Arbeitsansatzes war, im Gegensatz zu vorherigen Studien, die Durchführung der Untersuchung an nur einer Kohorte. Dadurch konnte die Güte der verschiedenen MRT-Verfahren direkt und quantitativ miteinander verglichen werden. Insgesamt unterstreichen die Erkenntnisse dieser Arbeit den Stellenwert und die mögliche klinische Relevanz der quantitativen MRT, insbesondere bei der Identifizierung atypischer Parkinsonsyndrome.

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Thiessen, Jonathan. « Development and application of quantitative MRI methods for assessing white matter integrity in the mouse brain ». 2012. http://hdl.handle.net/1993/9221.

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Healthy white matter in the brain and spinal cord is composed primarily of myelinated axons and glial cells. Myelinated axons transfer information between the peripheral nervous system and the central nervous system (CNS) as well as between centres within the CNS. Demyelination, a hallmark of neurodegenerative autoimmune diseases such as multiple sclerosis (MS), can cause nerve damage and degrade signal propagation. Magnetic resonance imaging (MRI) methods thought to assess myelin integrity and the structural integrity of axons are improving both the diagnosis and understanding of white matter diseases such as MS. Current methods, however, are sensitive to many different pathologies, making the interpretation of individual MRI results difficult. For this dissertation, several quantitative MRI methods were developed and compared, including single component T1 and T2 relaxometry, multicomponent T2 relaxometry, diffusion tensor imaging (DTI), and quantitative magnetization transfer imaging (qMTI). These methods were tested on agarose gels, fixed rat spinal cords, healthy control mice, and the cuprizone mouse model of demyelination. Quantitative MRI measurements were correlated to ultrastructural measurements of white matter to determine the influence myelin content and axonal structure have on different MRI methods. Cellular distributions measured in electron micrographs of the corpus callosum correlated strongly to several different quantitative MRI metrics. The largest Spearman correlation coefficient varied depending on cellular type: longitudinal relaxation rates (RA/T1) vs. the myelinated axon fraction ( r = 0.90/-0.90), the qMTI-derived bound pool fraction (f) vs. the myelin sheath fraction ( r = 0.93), and the DTI-derived axial diffusivity vs. the non-myelinated cell fraction (r = 0.92). Using Pearson’s correlation coefficient, f was strongly correlated to the myelin sheath fraction (r = 0.98) with a linear equation predicting myelin content (5.37f −0.25). Of the calculated MRI metrics, f was the strongest indicator of myelin content while longitudinal relaxation rates and diffusivity measurements were the strongest indicators of changes in tissue structure. Multiparametric MRI measurements of relaxation, diffusion, and magnetization transfer give a more complete picture of white matter integrity.

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Chapitres de livres sur le sujet "Quantitative magnetization transfer-MRI"

Kim, Mina, et Mara Cercignani. « Magnetization Transfer ». Dans Quantitative MRI of the Spinal Cord, 164–80. Elsevier, 2014. http://dx.doi.org/10.1016/b978-0-12-396973-6.00012-5.

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« Magnetization Transfer and Chemical Exchange Saturation Transfer Imaging in Cancer Imaging ». Dans Quantitative MRI in Cancer, 118–25. CRC Press, 2011. http://dx.doi.org/10.1201/b11379-14.

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Actes de conférences sur le sujet "Quantitative magnetization transfer-MRI"

Casella, Chiara, Jose Bourbon-Teles, Sonya Bells, Elizabeth Coulthard, Greg D. Parker, Anne Rosser, Derek K. Jones et Claudia Metzler-Baddeley. « E06 Drumming motor sequence training induces apparent myelin remodelling in huntington’s disease : a longitudinal diffusion MRI and quantitative magnetization transfer study ». Dans EHDN Abstracts 2021. BMJ Publishing Group Ltd, 2021. http://dx.doi.org/10.1136/jnnp-2021-ehdn.41.

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