Bibliographies thématiques / Qt 104

Littérature scientifique sur le sujet « Qt 104 »

Auteur : Grafiati

Publié le 26 juillet 2024

Mis à jour le 27 juillet 2024

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Articles de revues sur le sujet "Qt 104"

Etingof, Pavel, Nate Harman et Viktor Ostrik. « $p$-adic dimensions in symmetric tensor categories in characteristic $p$ ». Quantum Topology 9, n^o 1 (1 février 2018) : 119–40. http://dx.doi.org/10.4171/qt/104.

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Hunnicutt, Jennifer L., Chris M. Gregory, Michelle M. McLeod, Shane K. Woolf, Russell W. Chapin et Harris S. Slone. « Quadriceps Recovery After Anterior Cruciate Ligament Reconstruction With Quadriceps Tendon Versus Patellar Tendon Autografts ». Orthopaedic Journal of Sports Medicine 7, n^o 4 (1 avril 2019) : 232596711983978. http://dx.doi.org/10.1177/2325967119839786.

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Background: Quadriceps tendon (QT) autografts are being increasingly used for anterior cruciate ligament reconstruction (ACLR). A paucity of studies exist that compare QT autografts with alternative graft options. Additionally, concerns exist regarding quadriceps recovery after graft harvest insult to the quadriceps muscle-tendon unit. Purpose/Hypothesis: The purpose of this study was to compare quadriceps recovery and functional outcomes in patients with QT versus bone–patellar tendon–bone (BPTB) autografts. The hypothesis was that those with QT autografts would demonstrate superior outcomes. Study Design: Cohort study; Level of evidence, 3. Methods: Active patients with a history of primary, unilateral ACLR with soft tissue QT or BPTB autografts participated. Quadriceps recovery was quantified using variables of strength, muscle size, and activation. Knee extensor isometric and isokinetic strength was measured bilaterally with an isokinetic dynamometer and normalized to body weight. Quadriceps activation was measured with the superimposed burst technique. The maximal cross-sectional area of each quadriceps muscle was measured bilaterally using magnetic resonance imaging. Assessors of muscle size were blinded to the graft type and side of ACLR. Functional tests included hop tests and step length symmetry during walking, measured via spatiotemporal gait analysis. Self-reported function was determined with the International Knee Documentation Committee (IKDC) questionnaire. Neuromuscular and functional outcomes were expressed as limb symmetry indices (LSIs: [surgical limb/nonsurgical limb]*100%). Wilcoxon rank-sum tests were used to compare the LSIs and IKDC scores between groups. Results: There were 30 study participants (19 male, 11 female; median age, 22 years [range, 14-41 years]; median time since surgery, 8 months [range, 6-23 months]), with 15 patients in each group. There were no significant between-group differences in demographic variables or outcomes. LSIs were not significantly different between the QT versus BPTB group, respectively: knee extensor isokinetic strength at 60 deg/s (median, 70 [range, 41-120] vs 68 [range, 37-83]; P = .285), activation (median, 95 [range, 85-111] vs 92 [range, 82-105]; P = .148), cross-sectional area of the vastus medialis (median, 79 [range, 62-104] vs 77 [range, 62-95]; P = .425), single-leg hop test (median, 88 [range, 35-114] vs 77 [range, 49-100]; P = .156), and step length symmetry (median, 99 [range, 93-104] vs 98 [range, 92-103]; P = .653). The median IKDC scores between the QT and BPTB groups were also not significantly different: 82 (range, 67-94) versus 83 (range, 54-94); respectively ( P = .683). Conclusion: Patients with QT autografts demonstrated similar short-term quadriceps recovery and postsurgical outcomes compared with patients with BPTB autografts.

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Holmgren, David, Shiba Noory, Eva Moström, Hege Grindem, Anders Stålman et Tobias Wörner. « Weaker Quadriceps Muscle Strength With a Quadriceps Tendon Graft Compared With a Patellar or Hamstring Tendon Graft at 7 Months After Anterior Cruciate Ligament Reconstruction ». American Journal of Sports Medicine 52, n^o 1 (janvier 2024) : 69–76. http://dx.doi.org/10.1177/03635465231209442.

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Background: Impaired quadriceps muscle strength after anterior cruciate ligament reconstruction (ACLR) is associated with worse clinical outcomes and a risk of reinjuries. Yet, we know little about quadriceps muscle strength in patients reconstructed with a quadriceps tendon (QT) graft, which is increasing in popularity worldwide. Purpose: To describe and compare isokinetic quadriceps strength in patients undergoing ACLR with a QT, hamstring tendon (HT), or bone–patellar tendon–bone (BPTB) autograft. Study Design: Cross-sectional study; Level of evidence, 3. Methods: We included patients with QT grafts (n = 104) and matched them to patients with HT (n = 104) and BPTB (n = 104) grafts based on age, sex, and associated meniscal surgery. Data were collected through clinical strength testing at a mean of 7 ± 1 months postoperatively. Isokinetic strength was measured at 90 deg/s, and quadriceps strength was expressed as the limb symmetry index (LSI) for peak torque, total work, torque at 30° of knee flexion, and time to peak torque. Results: Patients with QT grafts had the most impaired isokinetic quadriceps strength, with the LSI ranging between 67.5% and 75.1%, followed by those with BPTB grafts (74.4%-81.5%) and HT grafts (84.0%-89.0%). Patients with QT grafts had a significantly lower LSI for all variables compared with patients with HT grafts (mean difference: peak torque: −17.4% [95% CI, −21.7 to −13.2], P < .001; total work: −15.9% [95% CI, −20.6 to −11.1], P < .001; torque at 30° of knee flexion: −8.8% [95% CI, −14.7 to −2.9], P = .001; time to peak torque: −17.7% [95% CI, −25.8 to −9.6], P < .001). Compared with patients with BPTB grafts, patients with QT grafts had a significantly lower LSI for all variables (mean difference: peak torque: −6.9% [95% CI, −11.2 to −2.7], P < .001; total work: −7.7% [95% CI, −12.4 to −2.9], P < .001; torque at 30° of knee flexion: −6.3% [95% CI, −12.2 to −0.5], P = .03; time to peak torque: −8.8% [95% CI, −16.9 to −0.7], P = .03). None of the graft groups reached a mean LSI of >90% for peak torque (QT: 67.5% [95% CI, 64.8-70.1]; HT: 84.9% [95% CI, 82.4-87.4]; BPTB: 74.4% [95% CI, 72.0-76.9]). Conclusion: At 7 months after ACLR, patients with QT grafts had significantly worse isokinetic quadriceps strength than patients with HT and BPTB grafts. None of the 3 graft groups reached a mean LSI of >90% in quadriceps strength.

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Martinelli, Marianna, Chiara Giubbi, Laura Saderi, Rosario Musumeci, Federica Perdoni, Biagio Eugenio Leone, Robert Fruscio et al. « Evaluation of Human Papilloma Virus (HPV) Genotyping and Viral Load Determination as Diagnostic Biomarkers of Cervical Cancer Risk ». International Journal of Molecular Sciences 24, n^o 2 (10 janvier 2023) : 1320. http://dx.doi.org/10.3390/ijms24021320.

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HPV testing in cervical cancer screening programs offers the possibility of introducing molecular standardized biomarkers for the triage of HPV-positive women. This study aimed to evaluate the role of HPV genotyping and viral load as possible diagnostic biomarkers of high-grade cervical lesions (CIN2+) by performing a preliminary evaluation of a new HPV test. Cervical specimens were obtained from 200 women referred for a colposcopy. Samples were tested using both Anyplex™ II HR-HPV as well as OncoPredict HPV® Screening (SCR) and quantitative typing (QT). Using a cycle threshold cutoff (Ct) of 36.8 for the SCR assay and 1.27 log10 (viral copies/104 cells) for the QT assay, relative clinical sensitivity for CIN2+ and relative clinical specificity for CIN2− as compared to Anyplex™ II HR-HPV were, respectively, 0.92 and 1.00 for SCR and 1.35 and 1.24 for QT. The distribution of high-risk HPV (HR-HPV) genotypes (p = 0.009) as well as the viral copy numbers (CIN2−: 3.7 log10 (viral copies/104 human cells); CIN2+: 4.3 log10 (viral copies/104 human cells); p = 0.047) were found to differ in women with high- and low-grade cervical lesions, suggesting a possible role of HPV genotyping and normalized viral load as potential biomarkers to identify women at increased risk of cervical lesions.

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Shao, Yan, Haitao Yu, Yan Yang, Min Li, Li Hang et Xinrong Xu. « A Solid Dispersion of Quercetin Shows Enhanced Nrf2 Activation and Protective Effects against Oxidative Injury in a Mouse Model of Dry Age-Related Macular Degeneration ». Oxidative Medicine and Cellular Longevity 2019 (7 novembre 2019) : 1–12. http://dx.doi.org/10.1155/2019/1479571.

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Age-related macular degeneration (AMD) represents a major reason for blindness in the elderly population. Oxidative stress is a predominant factor in the pathology of AMD. We previously evaluated the effects of phospholipid complex of quercetin (Q-PC) on oxidative injury in ARPE-19 cells, but the underlying mechanisms are not fully understood. Herein, the solid dispersion of quercetin-PC (Q-SD) was prepared with solubility being 235.54 μg/mL in water and 2.3×104 μg/mL in chloroform, which were significantly higher than that of quercetin (QT) and Q-PC. Q-SD also exhibited a considerably higher dissolution rate than QT and Q-PC. Additionally, Q-SD had Cmax of 4.143 μg/mL and AUC of 12.015 μg·h/mL in rats, suggesting better bioavailability than QT and Q-PC. Then, a mouse model of dry AMD (Nrf2 wild-type (WT) and Nrf2 knockout (KO)) was established for evaluating the effects of Q-SD in vivo. Q-SD more potently reduced retinal pigment epithelium sediments and Bruch’s membrane thickness than QT and Q-PC at 200 mg/kg in Nrf2 WT mice and did not work in Nrf2 KO mice at the same dosage. Additionally, Q-SD significantly decreased ROS and MDA contents and restored SOD, GSH-PX, and CAT activities of serum and retinal tissues in Nrf2 WT mice, but not in Nrf2 KO mice. Furthermore, Q-SD more potently increased Nrf2 mRNA expression and stimulated its nuclear translocation in retinal tissues of Nrf2 WT mice. Q-SD significantly increased the expression of Nrf2 target genes HO-1, HQO-1, and GCL of retinal tissues in Nrf2 WT mice, not in Nrf2 KO mice. Altogether, Q-SD had improved physicochemical and pharmacokinetic properties compared to QT and Q-PC and exhibited more potent protective effects on retina oxidative injury in vivo. These effects were associated with activation of Nrf2 signaling and upregulation of antioxidant enzymes.

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Romanova, V. A., A. S. Goncharov, N. N. Terebilina et V. S. Moiseev. « Cardiac damage in liver cirrhosis in alcohol abusers ». Terapevticheskii arkhiv 88, n^o 8 (15 août 2016) : 99–104. http://dx.doi.org/10.17116/terarkh201688899-104.

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Aim. To estimate the contribution of liver cirrhosis (LC) to the development of heart diseases in alcohol abusers. Subjects and methods. The investigation included 80 patients with alcoholic LC without a history of cardiovascular and respiratory diseases and, as a control group, 32 alcohol abusers without a history of chronic diseases of the liver and cardiovascular and respiratory systems; 45 patients with alcoholic cardiomyopathy (ACM) and congestive heart failure without a history of coronary heart disease and valvular diseases, among whom 11 patients were found to have LC. In addition to standard clinical examination, all the patients underwent electrocardiography, by estimating the corrected QT interval (QTc), standard echocardiography; and those without ACM underwent estimation of left ventricular (LV) kinetics using speckle-tracking echocardiography. Results. The patients with alcoholic LC were found to have a higher LV ejection fraction and a more obvious impairment of LV global longitudinal deformity, and more commonly LV diastolic dysfunction. 16 of the 80 patients with LC were observed to have moderate pulmonary hypertension while the mean pulmonary artery pressure (MPAP) was within the normal range in all the patients without LC. A prolonged QTc interval was revealed in the patients with LC. The duration of QTc was directly correlated with the MELD severity of LC. The patients with chronic heart failure in the presence of ACM and CL showed a more obvious LV diastolic dysfunction, as estimated by E/E’, a greater LV mass index, and a higher MPAP than those with ACM without LC. Conclusion. The LC patients both with ACM and without a history of diseases of the heart were noted to have its more evident disorders as diastolic dysfunction and elevated MPAP. Those without ACM were observed to have impaired LV global deformity and a prolonged QTc interval.

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Yildiz, Alaattin, Vakur Akkaya, Sevgi Sahin, Tufan Tükek, Mine Besler, Semra Bozfakioglu et Ferruh Korkut. « Qt Dispersion and Signal-Averaged Electrocardiogram in Hemodialysis and Capd Patients ». Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis 21, n^o 2 (mars 2001) : 186–94. http://dx.doi.org/10.1177/089686080102100213.

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Objective The aim of this study was to compare QT dispersion (QTd) and signal-averaged electrocardiogram (SA-ECG) parameters that may predict risk of malignant arrhythmias in patients on hemodialysis (HD), on continuous ambulatory peritoneal dialysis (CAPD), and in controls. Setting Controlled cross-sectional study in a tertiary- care setting. Patients 28 HD (M/F 18/10; mean age 32 ± 9 years), 29 CAPD (M/F 17/12; mean age 34 ± 10 years), and 29 healthy controls (M/F 17/12; mean age 32 ± 8 years) were included. Interventions On ECG, minimum (QTmin) and maximum (QTmax) QT duration and their difference (QTd) were measured. In SA-ECG, duration of filtered QRS, HFLA signals less than 40 μV, and RMS voltage (40 ms) were also measured. Results Higher serum Ca2+ and lower K+ levels were found in CAPD compared to HD. All QT parameters were increased in HD and CAPD compared to controls. QT dispersion was significantly prolonged in HD compared to CAPD. In HD, QTd was correlated with left ventricular (LV) mass index ( r = 0.53, p = 0.004), but not in CAPD ( r = -0.09, p = 0.63). QT dispersion was significantly prolonged in patients with LV hypertrophy compared to patients without hypertrophy on HD (68 ± 18 ms vs 49 ± 18 ms, p = 0.008). In the analysis of SA-ECG, 3 of the 28 (11%) HD and 2 of the 29 (7%) CAPD patients had abnormal late potentials. Patients on HD and CAPD had significantly higher filtered-QRS duration compared to controls (105 ± 15 ms and 104 ± 12 ms vs 95 ± 5 ms, respectively, p = 0.04). Patients with LV hypertrophy had higher filtered-QRS duration compared to patients without hypertrophy (109 ± 12 ms vs 95 ± 8 ms, p < 0.001). Conclusion Dialysis patients had prolonged QTd and increased filtered-QRS duration in SA-ECG compared to controls. Patients on HD had longer QTd than patients on CAPD. QTd has been correlated to LV mass index in HD, but not in CAPD. This difference might be due to the effect of different dialysis modalities on electrolytes, especially the higher serum Ca2+ levels.

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Saib, Anis, Walid Amara, Pascal Wang, Simon Cattan, Azeddine Dellal, Kais Regaieg, Stephane Nahon, Olivier Nallet et Lee S. Nguyen. « Lack of efficacy of hydroxychloroquine and azithromycin in patients hospitalized for COVID-19 pneumonia : A retrospective study ». PLOS ONE 16, n^o 6 (9 juin 2021) : e0252388. http://dx.doi.org/10.1371/journal.pone.0252388.

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Background Hydroxychloroquine combined with azithromycin (HCQ/AZI) has initially been used against coronavirus disease-2019 (COVID-19). In this retrospective study, we assessed the clinical effects of HCQ/AZI, with a 28-days follow-up. Methods In a registry-study which included patients hospitalized for COVID-19 between March 15 and April 2, 2020, we compared patients who received HCQ/AZI to those who did not, regarding a composite outcome of mortality and mechanical ventilation with a 28-days follow-up. QT was monitored for patients treated with HCQ/AZI. Were excluded patients in intensive care units, palliative care and ventilated within 24 hours of admission. Three analyses were performed to adjust for selection bias: propensity score matching, multivariable survival, and inverse probability score weighting (IPSW) analyses. Results Overall, 203 patients were included: 60 patients treated by HCQ/AZI and 143 control patients. During the 28-days follow-up, 32 (16.3%) patients presented the primary outcome and 23 (12.3%) patients died. Propensity-score matching identified 52 unique pairs of patients with similar characteristics. In the matched cohort (n = 104), HCQ/AZI was not associated with the primary composite outcome (log-rank p-value = 0.16). In the overall cohort (n = 203), survival and IPSW analyses also found no benefit from HCQ/AZI. In the HCQ/AZI group, 11 (18.3%) patients prolonged QT interval duration, requiring treatment cessation. Conclusions HCQ/AZI combination therapy was not associated with lower in-hospital mortality and mechanical ventilation rate, with a 28-days follow-up. In the HCQ/AZI group, 18.3% of patients presented a prolonged QT interval requiring treatment cessation, however, control group was not monitored for this adverse event, making comparison impossible.

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Gao, Yuanfeng, Wenling Liu, Cuilan Li, Xiaoliang Qiu, Xuguang Qin, Baojing Guo, Xueqin Liu et al. « Common Genotypes of Long QT Syndrome in China and the Role of ECG Prediction ». Cardiology 133, n^o 2 (24 octobre 2015) : 73–78. http://dx.doi.org/10.1159/000440608.

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Objectives: Genetic testing, a gold standard for long QT syndrome (LQTS) diagnosis, is time-consuming and costly when all the 15 candidate genes are screened. Since genotype-specific ECG patterns are present in most LQT1-3 mutation carriers, we tested the utility of ECG-guided genotyping in a large cohort of Chinese LQTS patients. Methods and Results: We enrolled 230 patients (26 ± 17 years, 66% female) with a clinical diagnosis of LQTS. Genotypes were predicted as LQT1-3 based on the presence of ECG patterns typical for each genotype in 200 patients (85 LQT1, 110 LQT2 and 5 LQT3). Family-based genotype prediction was also conducted if gene-specific ECG patterns were found in other affected family members. Mutational screening identified 104 mutations (44% novel), i.e. 46 KCNQ1, 54 KCNH2 and 4 SCN5A mutations. The overall predictive accuracy of ECG-guided genotyping was 79% (157/200) and 79% (67/85), 78% (86/110) and 80% (4/5) for LQT1, LQT2 and LQT3, respectively. The predictive accuracy was 98% (42/43) when family-based ECG assessment was performed. Conclusions: From this large-scale genotyping study, we found that LQT2 is the most common genotype among the Chinese. Family-based ECG-guided genotyping is highly accurate. ECG-guided genotyping is time- and cost-effective. We therefore recommend it as an optimal approach for the genetic diagnosis of LQTS.

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Gur, Ali, et Zeynep Ulutas. « Characteristic Electrocardiography Findings of COVID-19 Patients ». Archives of Iranian Medicine 24, n^o 9 (1 septembre 2021) : 706–12. http://dx.doi.org/10.34172/aim.2021.103.

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Background: Determining a relationship between coronavirus disease 2019 (COVID-19) and the ECG findings of the patients with this disease can assist in early diagnosis and patient management based on these findings. This study aimed to investigate whether COVID-19 patients had characteristic ECG findings in the acute period. Methods: A total of 124 patients were divided into two groups as those diagnosed with COVID-19 and controls. The ECGs of these patients were evaluated in terms of rate, rhythm, presence of ST changes, PR interval, QRS width, QTc and QT interval, and presence of right and left bundle branch blocks. Results: On the ECG, the median heart rate of the COVID-19 patients was 104/min (IQR: 99–114), and there was a significant difference compared to the control group (P<0.001). The median PR interval was 157/ms, the QRS width was 86 ± 9/ms in the COVID-19 patients, with no significant difference compared to the controls (P = 0.161 and P = 0.631, respectively). The median QT interval of the COVID-19 patients was normal (400/ms), but a significant difference was detected compared to the controls (P = 0.005). The QTc, ST change, AF, and presence of right and left bundle branch blocks were not significantly different between the two groups. Conclusion: Considering the importance of ECG findings in order to diagnose COVID-19 disease early, we can state that sinus tachycardia is very common in COVID-19 patients, but there is no characteristic ECG finding for COVID-19, including tachycardia.

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Chapitres de livres sur le sujet "Qt 104"

Ludin, Anwar. « C++, Qt, and Cascades ». Dans Learn BlackBerry 10 App Development, 59–98. Berkeley, CA : Apress, 2014. http://dx.doi.org/10.1007/978-1-4302-6158-2_3.

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Feather, Leonard, et Ira Gitler. « m ». Dans The Biographical Encyclopedia of Jazz, 425–89. Oxford University PressNew York, NY, 1999. http://dx.doi.org/10.1093/oso/9780195074185.003.0013.

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Abstract Mabern, harold jr., pno, comp; b. Memphis, TN, 3/20/36. Started on dms., pl. w. Frank Strozier while in hs. Pursued serious pno. study after hearing Phineas Newborn Jr. Moved to Chi. 1954; pl. w. Morris Ellis bb; Walter Perkins’ MJT+3; Bob Cranshaw; Frank Strozier; Bobby Bryant; Willie Thomas. Moved to NYC ’59; pl. w. Harry “Sweets” Edison ’59; Lionel Hampton ’60; Art Farmer–Benny Golson Jazztet ’61–2; Roy Haynes, Irene Reid, Arthur Prysock ’62; Miles Davis in Calif.; J. J. Johnson ’63–5; Wes Montgomery ’64; Joe Williams ’66–7; Lee Morgan ’67; Walter Bolden Trio ’73–4. Member of Stanley Cowell’s 7-pno. Piano Choir ’70. Pl. and/or rec. in ’70s w. George Coleman; Danny Moore; Billy Harper; Roy Haynes; Freddie Hubbard; R. R. Kirk; Hank Mobley; Clark Terry; Joe Newman; and many others. Regular member of G. Coleman’s qt. since the ’80s. Taught pno. and improv. at William Paterson Coll. since ’71. In ’90 and ’91 Mabern toured Japan w. the 100 Gold Fingers of Jazz, a gp. comprising 10 top jazz pnsts. “Music is my love,” says Mabern. “I never take it for granted.” A strong bebop-based, blues-grounded player, he has been unjustly neglected through much of his career. Favs: Phineas Newborn Jr., Ahmad Jamal; arr: Thad Jones. Polls: BMI Jazz Pioneer. Fests: Eur., Jap. w. Coleman, J. Newman. TV: Jazz Set w. Bobbi Humphrey ’71; Soul w. Lucky Thompson ’70s. CDs: Col.; Sack.; Prest.; w. G. Coleman (Evid.); Betty Carter (Cap.); Lee Morgan; Mobley; Hubbard (BN); J. J. Johnson (Imp.); Contemp. Pno Ens. (Evid.; Col.); Cecil Payne; Jimmy Forrest; Eric Alexander (Del.); Kirk (Merc.); Strozier; Louis Smith (Steep.); J. Griffin (Gal.); G. Benson (CTI).

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Actes de conférences sur le sujet "Qt 104"

Yu, Cun, Yanhong Shen, Lijun Huang, Haoran Huang, Xin Zhang, Shuaifeng Jia et Jia Liu. « The implementation of IEC60870-5-104 based on UML statechart and Qt state machine framework ». Dans 2015 5th International Conference on Electronics Information and Emergency Communication (ICEIEC). IEEE, 2015. http://dx.doi.org/10.1109/iceiec.2015.7284566.

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Rodrigues, António Filipe Pinto, et Bruno Tiago Madeira Morais Valentim. « Acquired long QT Syndrome : Case report ». Dans III SEVEN INTERNATIONAL MULTIDISCIPLINARY CONGRESS. Seven Congress, 2023. http://dx.doi.org/10.56238/seveniiimulti2023-107.

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Long QT syndrome, whether genetic or acquired, is closely associated with arrhythmogenic potential and consequently with syncope or even sudden death. This case report concerns a 77-year-old female who attended the emergency department for right-sided hemiparesis, diagnosed with ischemic stroke. She underwent Holter monitoring for paroxysmal atrial fibrillation, where an increase in the QT interval was found, which triggered a Torsades de Pointes by R on T phenomenon. After investigating the cause, it was found that the origin of the increase in the QT interval was iatrogenic. The drug that was influencing this change was Sotalol, which after being removed from the therapeutic table, reverted the QTc interval to within normal values.

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Черная, М. Е., А. А. Нерсесян, А. Р. Волкова et Ю. Ш. Халимов. « ПРЕДВАРИТЕЛЬНЫЕ РЕЗУЛЬТАТЫ ОЦЕНКИ ПОКАЗАТЕЛЕЙ СЕРДЕЧНОГО РИТМА ; У ПАЦИЕНТОВ С САХАРНЫМ ДИАБЕТОМ 1 ТИПА ПРИ РАЗЛИЧНЫХ УРОВНЯХ ГЛИКЕМИИ ». Dans X (XXIX) НАЦИОНАЛЬНЫЙ КОНГРЕСС ЭНДОКРИНОЛОГОВ с международным участием «Персонализированная медицина и практическое здравоохранение». ФГБУ «НМИЦ эндокринологии» Минздрава России, 2023. http://dx.doi.org/10.14341/cong23-26.05.23-108.

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ЦЕЛЬ: изучить показатели сердечного ритма и проводимости у пациентов с сахарным диабетом (СД) 1 типа при разных уровнях гликемии. МАТЕРИАЛЫ И МЕТОДЫ: в исследование включено 12 пациентов с СД 1 типа, из них 5 мужчин. Средний возраст составил 39,5±13 лет. Длительность СД составила 16,3±12,1 лет. Средний уровень глики- рованного гемоглобина - 7,8 ± 0,7%. Терапию шприц-ручками получало 5 пациентов, помповую инсулиноте- рапию - 7 пациентов. Проведено кардиоглюкомониторирование – одновременно выполнялось монитори- рование уровня глюкозы (система FreeStyle Libre) и холтеровское мониторирование ЭКГ (Кардиотехника-07, ИНКАРТ). Анализ показателей сердечного ритма и проводимости (частота сердечных сокращений (ЧСС), интервалы PQ, QT, нарушения ритма) проводился у пациентов в период их пребывания в диапазоне тяже- лой гипогликемии (<3,0 ммоль/л), легкой гипогликемии (3,0-3,9 ммоль/л), эугликемии (4,0-10,0 ммоль/л), легкой гипергликемии (10,1-14,0 ммоль/л). Также проведен анализ показателей сердечного ритма при колебаниях гликемии с невысокой скоростью изменения гликемии (2-5 ммоль/л/час) и при резких коле- баниях гликемии (>5 ммоль/л/час). РЕЗУЛЬТАТЫ: средняя ЧСС в течение периода наблюдения составила 80±9,7 сокр/мин. Средняя ЧСС в период пребывания в диапазоне тяжелой гипогликемии составила 65±15,3 сокр/мин, в период легкой гипогликемии – 87,8±24,1 сокр/мин, в период эугликемии – 69,8±20,2 сокр/мин, в период легкой гипер- гликемии – 90,3±9,3 сокр/мин. Средняя длительность интервала PQ в период пребывания в диапазоне тяжелой гипогликемии составила 172,0±36,7 мс, в период легкой гипогликемии – 146,8±34,4 мс, в период эугликемии – 157,7±29,5 мс, в период легкой гипергликемии – 154±39,3 мс. Средняя длительность QT в пе- риод пребывания в диапазоне тяжелой гипогликемии составила 431,1±11,8 мс, в период легкой гипоглике- мии – 423,6±13,7 мс, в период эугликемии – 427,3±17,7 мс, в период легкой гипергликемии – 421,0±15,6 мс. В период колебаний гликемии с невысокой скоростью средняя ЧСС составила 80,6±22,1 сокр/мин, средняя длительность интервала PQ 155,7±27,1 мс, средняя длительность интервала QT 422,2±11,0 мс. При резких колебаниях гликемии средняя ЧСС была существенно выше, чем при невысокой скорости колебаний гликемии, и составила 98,6±28,8 сокр/мин. Средняя длительность интервала PQ при резких колебаниях гликемии составила 145,0±26,1 мс, средняя длительность интервала QT – 443,8±9,5 мс. При резких изменениях гликемии (>5 ммоль/л/час) у пациентов зафиксированы аритмии, которые не выявлялись при нерезких изменениях гликемии (скорость 2-5 ммоль/л/час). У 1 пациента выявлен па- роксизм наджелудочковой тахикардии, у 2 пациентов – парные наджелудочковые экстрасистолы. Данные изменения выявлены при большой скорости колебаний гликемии (>5 ммоль/л/час) в диапазоне легкой гипогликемии и эугликемии. Также при резких изменениях гликемии зафиксированы эпизоды удлинения корригированного интервала QT >470 мс у 3 пациентов. ВЫВОДЫ: резкие колебания гликемии могут быть ассоциированы с увеличением ЧСС, возникновением нарушений сердечного ритма и проводимости.

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Кудинова, А. К., Н. Г. Варламова, Я. Э. Азаров et Е. Р. Бойко. « Динамика QT интервала ЭКГ элитных лыжников-гонщиков в тесте с максимальной физической нагрузкой ». Dans IX Vserossijskaja konferencija s mezhdunarodnym uchastiem «Mediko-fiziologicheskie problemy jekologii cheloveka». Publishing center of Ulyanovsk State University, 2023. http://dx.doi.org/10.34014/mpphe.2023-211-214.

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Изучена динамика длительности интервала QT и его корригированных форм (Bazett - QTc, Fridericia - QTf, Sagie/Framingham - QTs) у элитных лыжников-гонщиков во время прохождения максимального нагрузочного теста. Измерение ЭКГ и потребления кислорода проводили на системе Oxycon Pro, начиная с 120 Вт до отказа от нагрузки (шаг 40 Вт). Динамика QT представлена относительно потребления кислорода в процентах от максимального потребления кислорода (МПК). Длительности QTf и QTs обладали сходной динамикой, снижались при 60-100 % от МПК, однако значение QTс увеличилось при 40-50 % от МПК, далее не отличалось от исходного. Отмечено, что применение формулы Bazett для коррекции приводит к увеличению QTс, превышающему критические нормы. Ключевые слова: электрокардиограмма, реполяризация, спортсмены, максимальная физическая нагрузка.

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Fahal, AH, ES Ahmed, SM Bakhiet, OE Bakheet, LA Fahal, AA Mohamed, ESW Mohhamedelamin et al. « Once-weekly repurposed fosravuconazole versus daily itraconazole, with surgery, in patients with eumycetoma in Sudan : a randomised, double-blind, phase 2, proof-of-concept superiority trial ». Dans MSF Scientific Days International 2024. NYC : MSF-USA, 2024. http://dx.doi.org/10.57740/jznxuiaji7.

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INTRODUCTION Treatment options for the highly neglected fungal tropical disease eumycetoma are limited and poorly adapted to patients’ contexts, with surgery often required. The first-line treatment, itraconazole, thought to be 40% effective, must be taken twice daily for ≥12 months with food, making adherence difficult. An effective, affordable, context-appropriate treatment is urgently needed. The Drugs for Neglected Diseases Initiative (DNDi) repurposed the broad-spectrum antifungal agent fosravuconazole, developed by Eisai Ltd for onychomycosis. We aimed to compare two different doses of weekly fosravuconazole with standard-of-care daily itraconazole in patients with eumycetoma. METHODS This phase 2, randomised, double-blind, active-controlled, superiority trial was done at the Mycetoma Research Centre, Soba University Hospital, Sudan. Patients aged ≥15 years with a small-to-medium lesion (≥2 to <16 cm) caused by M mycetomatis requiring surgery were randomly assigned (1:1:1) to receive either 300 mg fosravuconazole weekly (group 1), 200 mg fosravuconazole weekly (group 2), or 400 mg itraconazole daily (group 3), for 12 months, together with surgery at 6 months in all groups. The primary efficacy endpoint, assessed in all patients receiving at least one dose of study drug (modified intention to treat), was complete cure at 12 months (absence of eumycetoma mass and sinuses and discharge with normal imaging; or a negative fungal culture if mass present). Safety was assessed in patients who received at least one dose of study drug. This study is registered with ClinicalTrials.gov (NCT03086226). RESULTS Between 9 May, 2017, and 10 June, 2021, 104 patients were randomised (34 to group 1, 34 to group 2, and 36 to group 3).Median age was 29.0 (IQR22.0–33.0), 23.0 (20.0–29.0) and 24.5 (19.5–33.0) years for Groups 1, 2, and 3 respectively. Complete cure rates at end of treatment were 50.0% (95% CI 32.4–67.6), 64.7% (46.5–80.3), and 75.0% (57.8–87.9) with Groups 1, 2 and 3, respectively, showing no superiority of fosravuconazole over the standard-of-care (p=0.030 for Group 2 vs Group 3; and p=0.347 for Group 1 vs Group 3; with significance level set at 0.022). Treatment-emergent adverse drug reactions were reported in one (3%) of 34 patients in group 2 (nausea or vomiting) and three (8%) of 36 patients in group 3 (cortisol decreased, QT prolonged). CONCLUSION Although not superior, fosravuconazole 200 mg seemed to have similar efficacy to itraconazole, coupled with advantages such as a weekly, not daily, administration, no food effect, and low risk for drug-drug interactions. An early access programme is under review by authorities in Sudan and a regulatory dossier and global access plan are under preparation.

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McCormick, Liam F., Nitika Gupta, Ohm Prakash, Lu-Yun Lian, Caroline Dart et Nordine Helassa. « BS10 Long QT syndrome-associated calmodulin mutations disrupt KV7.1 voltage-gated potassium channel function ». Dans British Cardiovascular Society Annual Conference, ‘100 years of Cardiology’, 6–8 June 2022. BMJ Publishing Group Ltd and British Cardiovascular Society, 2022. http://dx.doi.org/10.1136/heartjnl-2022-bcs.190.

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Gupta, Nitika, Liam F. McCormick, Ohm Prakash, Lu-Yun Lian, Caroline Dart et Nordine Helassa. « BS12 Calmodulin mutations associated with long QT syndrome impair L-type calcium channel regulation ». Dans British Cardiovascular Society Annual Conference, ‘100 years of Cardiology’, 6–8 June 2022. BMJ Publishing Group Ltd and British Cardiovascular Society, 2022. http://dx.doi.org/10.1136/heartjnl-2022-bcs.192.

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Chung, Cheuk To, Tong Liu, Wing Tak Wong, Oscar Chou, Keith Leung, Shuk Han Cheng, Sharen Lee et al. « 114 Attendance-related healthcare resource utilisation and costs in patients with long qt syndrome in hong kong : a retrospective cohort study ». Dans British Cardiovascular Society Annual Conference, ‘Future-proofing Cardiology for the next 10 years’, 5–7 June 2023. BMJ Publishing Group Ltd and British Cardiovascular Society, 2023. http://dx.doi.org/10.1136/heartjnl-2023-bcs.114.

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Xiaolin Zhou, Xin Zhu, Hui Wang et Daming Wei. « Measurement of QT interval prolongation : A comparative evaluation of six algorithms using simulated electrocardiograms ». Dans 2010 IEEE Region 10 Conference (TENCON 2010). IEEE, 2010. http://dx.doi.org/10.1109/tencon.2010.5686605.

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Charalambous, Christos, Praveetha Patalay, James Moon, Alun Hughes, Nishi Chaturvedi et Gaby Captur. « 93 Insulin resistance is associated with QT prolongation in the 1946 british birth cohort ». Dans British Cardiovascular Society Virtual Annual Conference, ‘Cardiology and the Environment’, 7–10 June 2021. BMJ Publishing Group Ltd and British Cardiovascular Society, 2021. http://dx.doi.org/10.1136/heartjnl-2021-bcs.92.

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