Littérature scientifique sur le sujet « Ptk2b »
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Articles de revues sur le sujet "Ptk2b"
Pallarès, Victor, Montserrat Hoyos, M. Chillón, Eva Barragán, M. Prieto Conde, Marta Llop, Aïda Falgàs et al. « Focal Adhesion Genes Refine the Intermediate-Risk Cytogenetic Classification of Acute Myeloid Leukemia ». Cancers 10, no 11 (13 novembre 2018) : 436. http://dx.doi.org/10.3390/cancers10110436.
Texte intégralPorter, Tyrel, Miguel Mayol del Valle et Lilia Kucheryavykh. « Ethnicity-Based Variations in Focal Adhesion Kinase Signaling in Glioblastoma Gene Expression : A Study of the Puerto Rican Hispanic Population ». International Journal of Molecular Sciences 25, no 9 (1 mai 2024) : 4947. http://dx.doi.org/10.3390/ijms25094947.
Texte intégralChen, Cui, Zhen Tao, Ya Li, Jie Li et Yang Xu. « MicroRNA214 expression inhibits HCC cell proliferation through PTK2b/ Pyk2 ». Cellular and Molecular Biology 68, no 1 (22 mai 2022) : 20–25. http://dx.doi.org/10.14715/cmb/2022.68.1.4.
Texte intégralLuo, Jinping, Lynda K. McGinnis, Carol Carlton, Hilary E. Beggs et William H. Kinsey. « PTK2b function during fertilization of the mouse oocyte ». Biochemical and Biophysical Research Communications 450, no 3 (août 2014) : 1212–17. http://dx.doi.org/10.1016/j.bbrc.2014.03.083.
Texte intégralN'Songo, Aurelie, Minerva M. Carrasquillo, Xue Wang, Jeremy D. Burgess, Thuy Nguyen, Yan W. Asmann, Daniel J. Serie et al. « African American exome sequencing identifies potential risk variants at Alzheimer disease loci ». Neurology Genetics 3, no 2 (avril 2017) : e141. http://dx.doi.org/10.1212/nxg.0000000000000141.
Texte intégralGiralt, Albert, Benoit de Pins, Carmen Cifuentes-Díaz, Laura López-Molina, Amel Thamila Farah, Marion Tible, Vincent Deramecourt et al. « PTK2B/Pyk2 overexpression improves a mouse model of Alzheimer's disease ». Experimental Neurology 307 (septembre 2018) : 62–73. http://dx.doi.org/10.1016/j.expneurol.2018.05.020.
Texte intégralNi, Bin, Jared S. Farrar, Shanshan Chen, Joseph C. Lownik et Francesco S. Celi. « A novel role for PTK2B in cultured beige adipocyte differentiation ». Biochemical and Biophysical Research Communications 501, no 4 (juillet 2018) : 851–57. http://dx.doi.org/10.1016/j.bbrc.2018.05.021.
Texte intégralChu, Weiwei, Lili Guan, Dihua Huang, Yuezhong Ren et Yan Zhou. « Lovastatin exerts protective effects on endothelial cells via upregulation of PTK2B ». Experimental and Therapeutic Medicine 12, no 3 (26 juillet 2016) : 1741–49. http://dx.doi.org/10.3892/etm.2016.3547.
Texte intégralPiaggio, Francesca, Veronica Tozzo, Cinzia Bernardi, Michela Croce, Roberto Puzone, Silvia Viaggi, Serena Patrone et al. « Secondary Somatic Mutations in G-Protein-Related Pathways and Mutation Signatures in Uveal Melanoma ». Cancers 11, no 11 (30 octobre 2019) : 1688. http://dx.doi.org/10.3390/cancers11111688.
Texte intégralLiu, Zhen, Kai-Min Hao, Hao-Yu Wang et Wen-Xiu Qi. « Histone deacetylase-6 modulates amyloid beta-induced cognitive dysfunction rats by regulating PTK2B. » NeuroReport 31, no 10 (21 mai 2020) : 754–61. http://dx.doi.org/10.1097/wnr.0000000000001481.
Texte intégralThèses sur le sujet "Ptk2b"
Melo, de Farias Ana Raquel. « Probing the Alzheimer’s disease risk gene PTK2B using human-derived induced neurons ». Electronic Thesis or Diss., Université de Lille (2022-....), 2023. http://www.theses.fr/2023ULILS062.
Texte intégralAlzheimer's disease (AD) is the main type of dementia and poses a significant global public health challenge. It is characterized by a progressive decline in cognition, memory, and behavioral functions and affects more than 55 million people worldwide. At the molecular level, AD is defined by the presence of aggregated neurofibrillary tangles within neurons and the accumulation of amyloid-β (Aβ) plaques in the brain. These pathological features are associated with alterations in neuronal activity, synapse loss, gliosis, and neuroinflammation, leading to irreversible neurodegeneration. AD etiology and pathophysiology involves a complex interplay between genetic and environmental factors. Genome-Wide Association Studies have identified several loci carrying single nucleotide polymorphisms (SNPs) associated with AD risk. Among these loci, the one harboring the Protein Tyrosine Kinase 2β (PTK2B) is highlighted in the present work. This gene encodes a protein tyrosine kinase that is involved in calcium-induced regulation of ion channels and activation of numerous signaling pathways, such as MAP kinase. Non-synonimous genetic variations in the PTK2B locus have been associated with an increased risk of AD and are thought to regulate PTK2B expression. However, both the physiological and pathophysiological roles of PTK2B are not fully understood. In the human brain, PTK2B expression is mainly observed in glutamatergic neurons. Its expression declines during AD progression and may contribute to neuronal dysfunctions observed in the disease, such as increased electrical excitability and synaptic alterations. Therefore, understanding the role of PTK2B in human neurons may contribute to reveal the mechanisms of neuronal dysfunctions in AD. Considering that, the aims of this thesis are to uncover the cellular processes and molecular pathways regulated by PTK2B in human neurons. To that, we took advantage of isogenic human induced-pluripotent stem cells (hiPSCs) to generate neurons expressing different levels of PTK2B. Next, we employed functional and molecular assays to probe the consequences of altered PTK2B expression both in a physiological and in an AD-like context. We show that reduced PTK2B expression leads to increased TAU phosphorylation at various epitopes associated with AD pathology, suggesting a central role of PTK2B in regulating TAU aggregation. Using single-cell transcriptomics, we also show that reduced PTK2B expression leads to specific transcriptional alterations related to neuronal electrical activity and synaptic transmission mainly in glutamatergic neurons. Calcium imaging experiments indicate that PTK2B downregulation contributes to increased calcium spikes frequency without affecting synchronization, indicating an elevated neuronal electrical activity. Additionally, results from electrophysiological recordings from multi-electrode array (MEA) show increased electrical activity and disrupted bursting patterns in PTK2B mutant neurons. Overall, this work sheds light on the involvement of PTK2B in AD-related cellular processes, providing insights into the molecular mechanisms and functional alterations associated with PTK2B dysregulation in human iPSC-derived neural cells
Schmachtenberg, Anna-Juliane. « Differentielle Expression des Tyrosin-Kinoms bei akuter lymphatischer Leukämie des erwachsenen Alters ». Doctoral thesis, Humboldt-Universität zu Berlin, 2018. http://dx.doi.org/10.18452/19369.
Texte intégralTyrosine kinases (TK) are key regulators of cellular signal transduction and affect cell cycle, cell survival, apoptosis, proliferation and differentiation. Dysregulation of TK activity contributes to the development of leukemia and other malignancies. So are 25 % of adult acute lymphoblastic leukemias (ALL) driven by the BCR-ABL1 translocation. Despite intensive therapy, the 5-year overall survival of adult patients with ALL is about 50 %. In contrast to conventional chemotherapeutic agents, the use of specific-acting TK-inhibitors offers an individualized therapeutic approach with less side-effects and a better outcome. To identify possible new therapeutic targets, a systematic survey of expression changes of the entire tyrosine kinome was carried out. A variety of different tyrosine kinases showed great changes in the expression profile of ALL-cells. Part of these expression changes can be attributed to a changed methylation profile in adult ALL. EPHA7 and PTK2 are potential markers for B-line ALL and the NTRK3, ERBB4 and ZAP70 for T-lines ALL. The interindividual varying expression of the tyrosine kinases EPHA3, EPHB3, KIT, ZAP70 and PDGFRB presumably allows a more precise risk classification. In particular, the tyrosine kinases ABL1, DDR1, EPHA7, FGFR1, ERBB4, FLT1, FLT3, FLT4, LCK, LTK, PTK2, PTK2B, PTK7, SRC, TEC and TYK2 are promising therapeutic targets, which promotes proliferation and/or inhibits apoptosis in the hematopoietic system. A proliferation promoting effect of overexpressed FLT4 could be shown for the first time. The variety of changes in the tyrosine kinase expression seems to play an important role in the development of ALL and TK could be promising new therapeutic targets.
LI, PETRI Giovanna. « SYNTHESIS AND BIOLOGICAL EVALUATION OF NEW IMIDAZO[2,1-b][1,3,4]THIADIAZOLE DERIVATIVES AS ANTICANCER AND ANTIBIOFILM AGENTS, AND PRECLINICAL INVESTIGATION OF ANTI-LDH-A COMPOUNDS AGAINST MALIGNANT MESOTHELIOMA ». Doctoral thesis, Università degli Studi di Palermo, 2020. http://hdl.handle.net/10447/395253.
Texte intégralChapitres de livres sur le sujet "Ptk2b"
Beck, T., A. Danneberg et V. Friedberg. « Wertigkeit histomorphologischer Befunde für die Ergebnisse operativer Therapie des Zervixkarzinom im Stadium pT2b ». Dans Gynäkologie und Geburtshilfe 1988, 560–61. Berlin, Heidelberg : Springer Berlin Heidelberg, 1989. http://dx.doi.org/10.1007/978-3-642-74784-7_282.
Texte intégralVernetti, Lawrence A., A. Jay Gandolfi et Raymond B. Nagle. « Selective Alteration of Cytokeratin Intermediate Filament by Cyclosporine A is a Lethal Toxicity in PTK2 Cell Cultures ». Dans Advances in Experimental Medicine and Biology, 847–51. Boston, MA : Springer New York, 1991. http://dx.doi.org/10.1007/978-1-4684-5877-0_119.
Texte intégral« PTK2 ». Dans Encyclopedia of Signaling Molecules, 4286. Cham : Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-67199-4_103157.
Texte intégralSafer, Daniel, et Vivianne T. Nachmias. « Thymosin β4 ». Dans Guidebook to the Cytoskeletal and Motor Proteins, 149–51. Oxford University PressOxford, 1999. http://dx.doi.org/10.1093/oso/9780198599579.003.0049.
Texte intégralFrederick, K. « Irrigation efficiency, a key issue ». Dans Water Crisis, 105–18. Taylor & Francis, 2006. http://dx.doi.org/10.1201/9781439834275.pt2b.
Texte intégral« Conclusion to Part II ». Dans XML Databases and the Semantic Web, 171. CRC Press, 2002. http://dx.doi.org/10.1201/9781420000023.pt2b.
Texte intégral« Some problems in the use of language in economics ». Dans Economics of Legal Relationships, 165–74. Routledge, 2007. http://dx.doi.org/10.4324/9780203964675.pt2b.
Texte intégralCarvalho, D., J. Paschoalin Filho et P. Albuquerque. « Behavior of continuous flight auger piles subjected to uplift load tests in unsaturated diabasic soil ». Dans Deep Foundations on Bored and Auger Piles - BAP V, 197–204. CRC Press, 2008. http://dx.doi.org/10.1201/9780203882870.pt2b.
Texte intégralRoovers, G., I. Rocabado et M. Huygens. « Future flood risks and comprehensive flood management ». Dans Water and Urban Development Paradigms, 251–56. CRC Press, 2008. http://dx.doi.org/10.1201/9780203884102.pt2b.
Texte intégral« Conclusion to Part II ». Dans Managing and Mining Multimedia Databases, 139. CRC Press, 2001. http://dx.doi.org/10.1201/9781420042559.pt2b.
Texte intégralActes de conférences sur le sujet "Ptk2b"
Ono, Matthew D., Daryl Preece, Michelle L. Duquette et Michael W. Berns. « Mitotic Tethers Connect Sister Chromosomes During Anaphase A in PtK2 Cells ». Dans Optical Trapping Applications. Washington, D.C. : OSA, 2017. http://dx.doi.org/10.1364/ota.2017.otm4e.4.
Texte intégralSkinner, Heath D., Uma Giri, John S. Yordy, Michael D. Story, Jing Wang, Lauren A. Byers, Michelle D. Williams et al. « Abstract 3441 : Proteomic profiling identifies PTK2/FAK as a targetable marker of radioresistance in head and neck cancer ». Dans Proceedings : AACR 106th Annual Meeting 2015 ; April 18-22, 2015 ; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-3441.
Texte intégralGomard, Guillaume, Donie Yidenekachew, Radwanul Hasan Siddique, Ruben Huenig, Hendrik Hoelscher, Karsten Bittkau, Valérie Depauw et al. « Controlling disorder for improved light management in solar cells ». Dans Optical Nanostructures and Advanced Materials for Photovoltaics. Washington, D.C. : OSA, 2015. http://dx.doi.org/10.1364/pv.2015.pth2b.1.
Texte intégralIsabella, O., R. Vismara, A. Ingenito et M. Zeman. « Decoupled front/back dielectric textures for flat ultrathin c-Si solar cells ». Dans Optical Nanostructures and Advanced Materials for Photovoltaics. Washington, D.C. : OSA, 2015. http://dx.doi.org/10.1364/pv.2015.pth2b.2.
Texte intégralAbass, Aimi, et Carsten Rockstuhl. « Analytical Model of Guided Modes in Structures with Rough Surfaces ». Dans Optical Nanostructures and Advanced Materials for Photovoltaics. Washington, D.C. : OSA, 2015. http://dx.doi.org/10.1364/pv.2015.pth2b.3.
Texte intégralDing, H., L. Lalouat, B. Gonzalez-Acevedo, A. Harouri, R. Orobtchouk, V. Depauw, E. Drouard et C. Seassal. « Pseudo-disordered design assists mono-crystalline Si thin film solar cells ». Dans Optical Nanostructures and Advanced Materials for Photovoltaics. Washington, D.C. : OSA, 2015. http://dx.doi.org/10.1364/pv.2015.pth2b.4.
Texte intégralSchumann, M. F., A. Abass, S. Wiesendanger, C. Rockstuhl et M. Wegener. « Cloaking of Contact Fingers on Solar Cells Enabled by Transformation Optics ». Dans Optical Nanostructures and Advanced Materials for Photovoltaics. Washington, D.C. : OSA, 2015. http://dx.doi.org/10.1364/pv.2015.ptu2b.3.
Texte intégralLi, Juntao, Kezheng Li, Christian Schuster, Rongbin Su, Xuehua Wang, Ben-Hur V. Borges, Thomas F. Krauss et Emiliano R. Martins. « Fourier analysis and Spatial resolution of light trapping nanostructures ». Dans Optical Nanostructures and Advanced Materials for Photovoltaics. Washington, D.C. : OSA, 2015. http://dx.doi.org/10.1364/pv.2015.pth2b.5.
Texte intégralKrč, Janez, et Marko Topič. « Nanostructures for light trapping in photovoltaic devices – approaches and challenges ». Dans Optical Nanostructures and Advanced Materials for Photovoltaics. Washington, D.C. : OSA, 2015. http://dx.doi.org/10.1364/pv.2015.ptu2b.1.
Texte intégralMellor, A., N. P. Hylton, F. Shirley, T. Thomas, K. H. Lee, Y. Al-Saleh, A. Braun et al. « Nanostructured Solar Cells : Surface Textures and Quantum Dots ». Dans Optical Nanostructures and Advanced Materials for Photovoltaics. Washington, D.C. : OSA, 2015. http://dx.doi.org/10.1364/pv.2015.ptu2b.2.
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