Littérature scientifique sur le sujet « Psoraleni »
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Articles de revues sur le sujet "Psoraleni"
Diekmann, Janina, Isabell Theves, Kristoffer A. Thom et Peter Gilch. « Tracing the Photoaddition of Pharmaceutical Psoralens to DNA ». Molecules 25, no 22 (10 novembre 2020) : 5242. http://dx.doi.org/10.3390/molecules25225242.
Texte intégralJamalis, Joazaizulfazli, Faten Syahira Mohamed Yusof, Subhash Chander, Roswanira Abd Wahab, Deepak P. Bhagwat, Murugesan Sankaranarayanan, Faisal Almalki et Taibi Ben Hadda. « Psoralen Derivatives : Recent Advances of Synthetic Strategy and Pharmacological Properties ». Anti-Inflammatory & ; Anti-Allergy Agents in Medicinal Chemistry 19, no 3 (3 septembre 2020) : 222–39. http://dx.doi.org/10.2174/1871523018666190625170802.
Texte intégralDa Silva, Vinicius Barreto, Daniel Fábio Kawano, Ivone Carvalho, Edemilson Cardoso Conceição, Osvaldo Freitas et Carlos Henrique Tomich de Paula Silva. « Psoralen and Bergapten : In Silico Metabolism and Toxicophoric Analysis of Drugs Used to Treat Vitiligo ». Journal of Pharmacy & ; Pharmaceutical Sciences 12, no 3 (9 décembre 2009) : 378. http://dx.doi.org/10.18433/j3w01d.
Texte intégralPatel, Kanika, Vikas Kumar, Amita Verma, Mahfoozur Rahman et Dinesh Kumar Patel. « Health Benefits of Furanocoumarins ‘Psoralidin’ An Active Phytochemical of Psoralea corylifolia : The Present, Past and Future Scenario ». Current Bioactive Compounds 15, no 4 (4 juillet 2019) : 369–76. http://dx.doi.org/10.2174/1573407214666180511153438.
Texte intégralHuseyn A. Abiyev et Khayala R. Mammadova. « Effects of α-tocopherol on phototoxicity of 8 - methoxypsoralene ». Magna Scientia Advanced Biology and Pharmacy 2, no 1 (30 mars 2021) : 01–08. http://dx.doi.org/10.30574/msabp.2021.2.1.0005.
Texte intégralZhao, Gen-hua, Cui-ping Yan, Zi-sheng Xu, Qian-qian Gao, Zhi-peng Chen et Wei-dong Li. « The Effect of Salt-Processed Psoralea corylifolia on Generative Organ Targeting ». Journal of Analytical Methods in Chemistry 2016 (2016) : 1–12. http://dx.doi.org/10.1155/2016/7484202.
Texte intégralChen, Yuling, Rong Wang et Zilin Chen. « Sensitive determination of psoralen and isopsoralen in Fructus Psoraleae by online solid phase microextraction with a porphyrin-based porous organic polymer modified capillary ». Analytical Methods 11, no 1 (2019) : 29–35. http://dx.doi.org/10.1039/c8ay01885e.
Texte intégralThomas, D. C., D. L. Svoboda, J. M. Vos et T. A. Kunkel. « Strand specificity of mutagenic bypass replication of DNA containing psoralen monoadducts in a human cell extract. » Molecular and Cellular Biology 16, no 5 (mai 1996) : 2537–44. http://dx.doi.org/10.1128/mcb.16.5.2537.
Texte intégralGrass, Joshua A., Derek J. Hei, Ken Metchette, George D. Cimino, Gary P. Wiesehahn, Laurence Corash et Lily Lin. « Inactivation of Leukocytes in Platelet Concentrates by Photochemical Treatment With Psoralen Plus UVA ». Blood 91, no 6 (15 mars 1998) : 2180–88. http://dx.doi.org/10.1182/blood.v91.6.2180.
Texte intégralGrass, Joshua A., Derek J. Hei, Ken Metchette, George D. Cimino, Gary P. Wiesehahn, Laurence Corash et Lily Lin. « Inactivation of Leukocytes in Platelet Concentrates by Photochemical Treatment With Psoralen Plus UVA ». Blood 91, no 6 (15 mars 1998) : 2180–88. http://dx.doi.org/10.1182/blood.v91.6.2180.2180_2180_2188.
Texte intégralThèses sur le sujet "Psoraleni"
Silva, Lidércia Cavalcanti Ribeiro Cerqueira e. « Desenvolvimento de estratégias analíticas para determinação de flavanonas e psoraleno por CLAE-DAD em sucos de laranjas de diferentes procedências ». reponame:Repositório Institucional da UFBA, 2009. http://www.repositorio.ufba.br/ri/handle/ri/9877.
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CAPES
Este trabalho foi desenvolvido no âmbito do PRONEX – NQA e descreve o estudo através da técnica da Cromatografia Líquida de Alta Eficiência acoplada a detector de arranjo de diodos - CLAE-DAD nas análises de amostras de sucos de laranja obtidos por processos extrativos diversificados (espremidos a mão, extração em condições industriais com posterior comercialização em longo prazo e obtido através de máquinas tipo fresh-in-squeeze) para a identificação de flavonóides e psoraleno. Os diversos sucos foram submetidos às etapas de extração líquido-líquido e posterior análises por CLAE-DAD. Estes procedimentos permitiram identificar e quantificar algumas flavanonas e psoraleno presentes nos sucos cítricos. Dentre as flavanonas se determinou hesperidina, naringina, naringenina e poncirina. As faixas de concentrações destes compostos variaram de 17,8 - 245 mg 100 g-1 para hesperidina, 0,01 – 0,08 mg 100 g-1 para naringina, 0,05 – 0,170 mg 100 g-1 para naringenina e de 0,06 – 0,36 mg 100 g-1 para poncirina. Quanto ao psoraleno, em algumas amostras dos sucos, as concentrações estavam abaixo do limite de quantificação (< 0,02) e variou de < 0,02 – 0,05 mg 100 g-1. Estes resultados sugerem que o modo de obtenção dos sucos e os critérios de extração dos constituintes podem influenciar tanto nos teores dos flavonóides no suco como nas detecções de suas concentrações através da técnica aplicada. Para exames das informações geradas foram empregadas metodologias estatísticas multivariadas por meio de Análises de Componentes Principais (PCA) e Análise de Agrupamentos Hierárquicos (HCA) executando o estudo exploratório dos dados para avaliar tendências e discriminar amostras dos sucos de laranja quanto a sua origem, tipos de tratamentos de extração e características químicas para os teores de flavonóides e psoraleno.
Salvador
Miranda, Amanda Rodrigues. « Estudo da eficácia, segurança e tolerabilidade do Brosimum gaudichaudii Trécul em indivíduos adultos portadores de vitiligo ». Universidade Federal de Goiás, 2014. http://repositorio.bc.ufg.br/tede/handle/tede/6126.
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Vitiligo is a chronic disease of skin, acquired and idiopathic, characterized by circumscribed depigmented macules or patches. The treatment is still a challenge and don´t have an effective treatment that may improve all patients. The traditional psoralen photosensitizers are options for the treatment of vitiligo. In the Brazilian cerrado is popularly known action of Brosimum gaudichaudii Trécul (BGT), or mamacadela, which is an herbal psoralen. The goal of this study was evaluate the efficacy, safety and tolerability of BGT in adult patients with vitiligo, in topical and systemic presentations. A randomized controlled trial, double-blind and placebo-controlled was conducted. Of the 58 selected patients, 33 were randomized, 17 in the treatment group (G1) and 16 in the placebo group (G2). These remained until the end of the study 10 patients in G1 and G2 in 6 patients. The interventions were 800 mg / day of medication per orally and use of the ointment for 22 weeks, together with graded and daily photoexposure. The effectiveness of the BGT was assessed using the Vitiligo Area Score Index (VASI), applied by a dermatologist at all clinic visits. Already the safety and tolerability were assessed by laboratory tests before and during treatment, and observation of adverse events. All patients were classified with generalized vitiligo. The group that received the medication (G1) improved significantly VASI in intra-group evaluation (p <0.05) and also a higher proportion of repigmentation compared to G2. The VASI don´t have association with the analysis variables (gender, age, skin type, previous treatment, education, emotional stress, time of diagnosis, treatment adherence) (p> 0.05). Adherence to photoexposure was irregular in both groups, and don´t have statistically significant relationship with changes of VASI (p > 0.05). Laboratory tests showed no significant changes. Adverse events were mild and transient and the most common being erythema, and occurred predominantly in G1 patients. Therefore, it can be concluded that the BGT is effective in the treatment of vitiligo, with safe and well tolerated in the long term.
O vitiligo é dermatose crônica adquirida, idiopática, que se manifesta por manchas acrômicas e bem delimitadas. Seu tratamento ainda é um desafio e não existe até o momento intervenção completamente eficaz. Os psoralenos são fotossensibilizantes tradicionais utilizados para o tratamento do vitiligo. No cerrado brasileiro é popularmente conhecida a ação da planta mamacadela (Brosimum gaudichaudii Trécul (BGT)) devido a presença de derivados psoralênicos em sua composição . O presente estudo teve como objetivo avaliar a eficácia, segurança e tolerabilidade de formulações farmacêuticas contendo extrato de raízes de BGT em pacientes adultos portadores de vitiligo, nas apresentações tópica e sistêmica. Foi realizado ensaio clínico randomizado, duplo-cego e placebo-controlado. Dos 58 pacientes selecionados, 33 foram randomizados, sendo 17 no grupo 1 (G1), de tratamento, e 16 no grupo 2 (G2), placebo. Destes, permaneceram até o final do estudo 10 pacientes no G1 e 6 pacientes no G2. Foram administrados 800 mg/dia da medicação, via oral, além da pomada, durante 22 semanas, associados a fotoexposição diária e gradativa. A eficácia do BGT foi avaliada através do Vitiligo Area Score Index (VASI), aplicado por dermatologista em todas as visitas clínicas. Já a segurança e tolerabilidade foram avaliadas pela realização de exames laboratoriais, antes e durante o tratamento, além da observação de eventos adversos. Todos os pacientes foram classificados com vitiligo generalizado. O grupo que recebeu a medicação (G1) apresentou melhora significativa do VASI na avaliação intragrupos (p<0,05) e também maior proporção de repigmentação quando comparado ao G2. O VASI não demonstrou associação com as variáveis de análise (sexo, idade, fototipo, tratamento prévio, escolaridade, estresse emocional, tempo de diagnóstico, adesão ao tratamento) (p>0,05). A adesão à fotoexposição foi irregular em ambos os grupos e não apresentou relação estatisticamente significante com as alterações do VASI (p>0,05). Em consonância, os exames laboratoriais não apresentaram alterações significativas. Os eventos adversos foram leves e transitórios, sendo mais comum o eritema, e ocorreram predominantemente nos pacientes do G1. Portanto, pode-se concluir que o BGT é eficaz no tratamento do vitiligo, sendo seguro e bem tolerado a longo prazo.
Nguyen, Christophe. « Contribution à l'étude de la production de psoralène (furocoumarine) par la culture in vitro de plantes du genre psoralea (leguminosae) ». Vandoeuvre-les-Nancy, INPL, 1992. http://www.theses.fr/1992INPL085N.
Texte intégralSilva, Filho Omar Paulino. « Obtenção de pellets a partir dos extratos líquidos padronizados de Brosimum gaudichaudii Trécul (Moraceae) ou Lafoensia pacari A. St.-Hil. (Lythraceae) ». Universidade Federal de Goiás, 2014. http://repositorio.bc.ufg.br/tede/handle/tede/7463.
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES
Pellets are spherical solid oral dosage forms that can be used in the development of new pharmaceutical products with standardized plant extracts. Brosimum gaudichaudii Trécul (Moraceae) and Lafoensia pacari A. St.-Hil. (Lythraceae) are typical species from the Cerrado biome. The extract obtained from the roots of B. gaudichaudii is traditionally used in the treatment of vitiligo, its effectiveness is due to the presence of the chemical markers psoralen and bergapten. As for L. pacari, the barks of the branches and trunk are traditionally used in the treatment of gastric ulcers, highly valued for there anti-inflammatory and wound healing because of there ellagic acid content. For each of these species optimal extractive methods exist to obtain standardized liquid extracts. However there are no studies that propose the development of solid oral dosage forms from them. Thus, the present study is aimed at obtaining pellets from the standardized liquid extract of the B. gaudichaudii roots, furthermore to determine the efficiency of a photoprotector coating on the stability of psoralen and bergapten and also obtaining pellets with standardized liquid extract of the L. pacari barks from the branches and trunk. The B. gaudichaudii roots were collected in the city of Jussara, Goiás, and the L. pacari barks in Niquelândia, Goiás. Separately, the raw materials were cleaned, dried in an oven with forced air circulation, then subsequently milled for the extractive process. After the standard liquid extract of B. gaudichaudii had been obtained, six formulas were developed at bench scale. Among these, one stood out by the homogeneity of the lot and the sphericity of its pellets. This formula had been selected to be sacaled-up and it`s composition had been formed by 49.5% (w/w) of microcrystalline cellulose (MCC), 1% (w/w) of hydroxypropylmethyl cellulose (HPMC) and 49.5% (w/w) of that extract. The pellets obtained from the scaled formula were divided into two portions, one of them had been coated with a photoprotective layer and both were subjected to a photostability test. The degradation of the markers had been evident only in the uncoated pellets. The reduction of 1.87% (w/w) in the content of psoralen and 8.1% (w/w) in bergapten content had been observed after 3 J/cm2 exposure to UVB radiation. After exposing to 30 J/cm2 of UVA, there had been a reduction of 24.1% (w/w) of psoralen and 28.48% (w/w) of bergapten. Therefore, the application of the photoprotective coating had been an effective alternative and ensured the stability of the chemical markers after the test. With respect to the liquid extract of L. pacari, 13 formulas were obtained among which only two formed pellets whose batch homogeneity had been greater than 70%. Among them, only one had been chosen to obtain the first scaled-up model. With the production of the scaled-up batch, it had been observed that formulas prepared with a lower proportion of standardized liquid extract of L. pacari had enabled us to obtaing more homogeneous, spherical and a smoother pellets. Based on these results and due to the innovative character of the studies, this work can be used as a model for future trials designed to obtain pellets with standardized liquid extract of B. gaudichaudii or L. pacari.
Pellets são formas farmacêuticas sólidas orais esféricas que podem ser utilizadas no desenvolvimento de novos produtos farmacêuticos a partir de extratos vegetais padronizados. Brosimum gaudichaudii Trécul (Moraceae) e Lafoensia pacari A. St.-Hil. (Lythraceae) são espécies típicas do bioma Cerrado. O extrato obtido das raízes de B. gaudichaudii é utilizado tradicionalmente no tratamento de vitiligo, cuja eficácia se deve pela presença dos marcadores químicos psoraleno e bergapteno. Quanto à espécie L. pacari, são tradicionalmente utilizados as cascas dos galhos e do tronco no tratamento de úlceras gástricas, cuja ação anti-inflamatória e cicatrizante é atribuída ao ácido elágico. Para cada uma destas espécies existem métodos extrativos otimizados para obtenção de extratos líquidos padronizados nos respectivos marcadores químicos. No entanto, não há estudos que proponham o desenvolvimento de formas farmacêuticas sólida orais a partir destes. Assim, o presente trabalho teve como objetivo obter pellets a partir do extrato hidroalcoólico das raízes de Brosimum gaudichaudii, padronizado em psoraleno e bergapteno, determinar a eficácia do revestimento fotoprotetor na estabilidade do psoraleno e bergapteno, além de obter pellets com o extrato hidroalcoólico das cascas dos galhos e do tronco de Lafoensia pacari, padronizado em ácido elágico. As raízes de B. gaudichaudii foram coletadas no município de Jussara, Goiás, e as cascas dos galhos e do tronco de L. pacari em Niquelândia, Goiás. Separadamente, as matérias-primas vegetais foram limpas, secas em estufa com circulação forçada de ar, posteriormente trituradas para a obtenção dos respectivos extratos líquidos padronizados. A partir do extrato líquido padronizado de B. gaudichaudii, foram obtidas seis fórmulas em escala de bancada. Dentre estas, uma se destacou pela homogeneidade do lote e pela esfericidade dos pellets. Deste modo, a fórmula que se destacou foi selecionada e escalonada, sua composição é formada pela mistura de XX% (m/m) de celulose microcristalina (CMC), X% (m/m) de hidroxipropilmetilcelulose (HPMC) e 49,5% deste extrato. Os pellets obtidos a partir da fórmula escalonada foram divididos em duas partes, em uma foi aplicado o revestimento fotoprotetor e ambas foram submetidas ao ensaio de fotoestabilidade. Desse modo, a degradação dos marcadores foi evidente apenas nos pellets sem o revestimento, cuja redução de no teor de psoraleno e bergapteno foi igual a 1,87% (m/m) e 8,1% (m/m), após a exposição a 3 J/cm2 de radiação UVB. Após a exposição a 30 J/cm2 de UVA, houve a redução de 24,1% (m/m) de psoraleno e 28,48% (m/m) de bergapteno. Portanto, a aplicação do revestimento fotoprotetor foi uma alternativa eficaz e garantiu a estabilidade dos marcadores químicos após o ensaio. Com relação ao extrato líquido de L. pacari, foram obtidas 13 fórmulas, dentre as quais apenas duas formaram pellets cuja homogeneidade dos lotes foi superior a 70% e apenas uma foi escolhida como modelo para a obtenção do lote piloto. Com a produção do lote piloto foi observado que fórmulas elaboradas com menor proporção do extrato padronizado de L. pacari e a mecanização do processo de mistura dos componentes da fórmula, possibilitam a obtenção de pellets mais esféricos, homogêneos e com superfície menos irregular. Diante dos resultados obtidos e devido ao caráter inovador dos estudos realizados, este trabalho pode ser utilizado como modelo para ensaios futuros destinados a obtenção de pellets com o extrato líquido padronizado de B. gaudichaudii ou L. pacari.
Sándor, Zoltán. « Mutagenic properties of psoralen-modified triple helix forming oligonucleotides ». Lund : Dept. of Medical Microbiology, Malmö General Hospital, Lund University, 1998. http://catalog.hathitrust.org/api/volumes/oclc/39774150.html.
Texte intégralKrieger, Célia. « Identification moléculaire et caractérisation fonctionnelle d'une nouvelle sous-famille de cytochromes P450, CYP71AZ, impliquée dans la synthèse de furanocoumarines et coumarines chez Pastinaca sativa ». Thesis, Université de Lorraine, 2014. http://www.theses.fr/2014LORR0185/document.
Texte intégralFuranocoumarins (FCs) are secondary metabolites mainly synthetized in four botanical families deriving from the phenylpropanoid biosynthetic pathway. These phytoalexins are involved in plant defense mechanisms and present strong therapeutic potential. Early studies in the 1960s based on cell cultures and the use of radiolabeled precursors have shown that many enzymes involved in this pathway belong to the cytochrome P450 family (P450s). Only two of them had been identified from a molecular point of view at the beginning of this thesis. In order to generate information regarding the genome of plants producing FCs, we sequenced the mRNA extracted from leaves of Pastinaca sativa, Ruta graveolens, and Cullen cinereum. In silico analysis of these three libraries identified nearly 800 cDNA fragments encoding for P450s. Previous studies in the laboratory and comparative transcriptome analysis of these three plants have led us to focus on the subfamily CYP71AZ through a detailed study of CYP71AZ3 and CYP71AZ4. Functional characterization of these enzymes was performed in an eukaryote heterologous expression system: Saccharomyces cerevisiae. The results showed that CYP71AZ4 had a broad substrate specificity enough as it could metabolize one FC and 4 coumarins. The analysis and comparison of the kinetic constants for each of these substrates indicate, however, that the preferred substrate is psoralen. The functional characterization of CYP71AZ3 showed that this enzyme could hydroxylate esculetin, a coumarin, but played no role in the synthesis of FCs. This study highlights the functional diversity within a single enzyme subfamily and allows to issue new hypotheses about the emergence of this biosynthetic pathway in Apiaceae on one hand, and among other botanical families on the other hand
Doerper, Sébastien. « Modification de la synthèse des furocoumarines chez Ruta graveolens L. par une approche de génie métabolique ». Thesis, Vandoeuvre-les-Nancy, INPL, 2008. http://www.theses.fr/2008INPL070N/document.
Texte intégralGarden Rue (Ruta graveolens L.) is a plant known as being particularly rich in secondary metabolites and in particular producing molecules of pharmaceutical interest like furocoumarines. By the use of a metabolic engineering approach, we tried to increase the content of furocoumarines produced in these plants but also to better understand the regulation mechanisms of the phenylpropanoïd biosynthesis pathway. To achieve these goals we transformed Ruta plants with various genes placed under the control of a strong constitutive promoter, CaMV 35S promoter. The plants we obtained were analyzed for their ability to overproduce furocoumarines but also other phenylpropanoïds like ferulate, umbelliferone, scopoletine or rutin. Using Real Time PCR experiments, a correlation was carried out with the level of expression of each transgene and several endogenous genes. Plants overexpressing either the Ruta or the Arabidopsis Coumaroyl ester 3 '-Hydroxylase (CYP98A22 and CYP98A3 respectively) display both a significant increase (3 time level) of the furocoumarin. However if the S-98A22 plants are characterized by a reduction in the production of rutin and umbelliferone, S-98A3 transgenic plants display a significant increase scopoletine and umbelliferone content. These results suggest the coexistence of two C3'H having different functions in Ruta. One of them might be involved more specifically in the synthesis of scopoletine. If the transformation of Ruta with genes belonging to the CYP98A family generates an enlarged of the secondary metabolism, we also showed that the overexpression of a gene belonging to the furocoumarins biosynthesis pathway (CYP71AJ1, the psoralen synthase) allowed a specific stimulation. Indeed a 4 time increase of the content of furocouramins was noticed in these transgenic plant lines. This work made it possible to make evidence of the interest of a metabolic engineering approach to generate plants of interest for the production of pharmaceutical molecules
Reis, Karinna Bannach. « Extrato padronizado de Ruta graveolens L. : avaliação de seu potencial no controle da brusone em arroz ». Universidade Federal de Goiás, 2013. http://repositorio.bc.ufg.br/tede/handle/tede/3066.
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Ruta graveolens has been successfully applied for many human diseases treatment and promises a well succeed alternative for plant diseases control because it has also phytoalexins in its composition. The aim of this study was to standardise the R. graveolens liquid extract and evaluate its potential for controlling rice (Oryza sativa) leaf blast (Magnaporthe oryzae). The drug has been characterized, the liquid extract obtained and the methodology for quantifying the standards components, furanocoumarins psoralen and bergapten, validated by high performance liquide chromatography. The components of essential oil obtained from standardized liquid extract were characterized by gas chromatography-mass spectrometry. In a completely randomized design, conducted in artificial hydrophobic surface with three replications and eleven treatments composed of M. oryzae conidial suspension (105 con.ml-1) mixed with R. graveolens standardized extract (0.01 to 0.10 g.mL-1), or furocoumarins psoralen (0.18 to 1.82 μg. mL-1), or bergapten (0.29 to 2.91 μg. mL-1), or water (control). It was evaluated the inhibition of conidial germination and appressorium formation and the median lethal dose (LD50). A second assay, in a completely randomized design in three replications was conducted in greenhouse conditions. It was composed of 21 days old rice plants, which were sprayed with a mixture containing M. oryzae conidial suspension (3x105 con.ml-1) and R. graveolens extract, without dilution, or furocoumarins psoralen (18.26 μg. mL-1), or bergapten (29.14 μg. mL-1), or water (control). Nine days after inoculation, leaf blast severity was scored with a diagrammatic scale, the data were statistically analyzed and means compared. The standardized plant extract inhibited M. oryzae conidial germination (LD50=0.237mg) and appressorium formation (LD50=0.121 mg) up to 100% and reduced 80.84% of leaf blast. By fluorescence microscopy it was possible to observe that standardized plant extract did not damage M. oryzae cell wall and plasma membrane, indicating another type of interaction to inhibit conidia development. Isolated standards furanocoumarins psoralen and bergapten did not inhibit conidial germination and appressorium formation and reduce leaf blast severity proportionally, suggesting that synergistic interactions between extract and essential oil components were responsible for the success of R. graveolens in suppressing rice disease, making it an alternative to compose rice blast management.
Ruta graveolens é utilizada com sucesso no tratamento de diversas patologias humanas e possui potencial para o controle alternativo de fitopatógenos, pois também apresenta fitoalexinas em sua composição. O objetivo deste estudo foi padronizar o extrato vegetal líquido de R. graveolens e avaliar seu potencial para o controle da brusone foliar. O material vegetal foi caracterizado, o extrato líquido obtido e a metodologia para a quantificação dos padrões psoraleno e bergapteno foi validada por cromatografia líquida de alta eficiência. Os componentes do óleo essencial obtidos a partir do extrato líquido padronizado foram caracterizados por cromatografia gasosa acoplada à espectrometria de massas. No ensaio conduzido em superfície hidrofóbica artificial, com três repetições e onze tratamentos, 10 μL da suspensão de conídios de Magnaporthe oryzae (105 con/mL) foram misturadas com o extrato vegetal padronizado (0,01 a 0,10 g/mL), ou as furanocumarinas psoraleno (0,18 a 1,82 μg/mL) e bergapteno (0,29 a 2,91 μg/mL), ou água (controle). Avaliou-se a inibição da germinação conidial e da formação dos apressórios determinando-se a dose letal capaz de inibir 50% dos indivíduos (DL50). No experimento conduzido em casa de vegetação e com três repetições, plantas de arroz com 21 dias após plantio foram pulverizadas com uma suspensão de conídios de M. oryzae (3x105 com/mL) misturada com extrato vegetal padronizado sem diluição, ou psoraleno (18,26 μg/mL), ou bergapteno (29,14 μg/mL), ou água (controle). Após nove dias da inoculação, avaliou-se a severidade de brusone foliar com uma escala de 10 graus, os dados foram analisados estatisticamente e as médias comparadas. O extrato vegetal padronizado inibiu a formação de tubo germinativo (DL50= 0,237 mg) e a formação de apressório (DL50= 0,121 mg) de M. oryzae em até 100%, e reduziu a severidade de brusone nas folhas em 80,84%. Através de microscopia de fluorescência, não foi observada ação do extrato padronizado em membrana plasmática e parede celular de M. oryzae, o que indica outro tipo de interação para inibir o desenvolvimento do conídio. Os padrões psoraleno e bergapteno não inibiram proporcionalmente a germinação e a formação de apressório, como também não reduziram a severidade de brusone nas folhas em sua forma isolada, o que sugere que interações sinérgicas entre os diversos componentes do extrato e do óleo essencial de R. graveolens foram responsáveis pelo sucesso do extrato padronizado em suprimir a brusone foliar, tornando-o uma alternativa para compor o manejo de brusone em arroz.
Holland, Julie. « Studies on the genetic and biochemical properties of a PUVA hyper-resistant mutant of Escherichia coli ». Thesis, Nottingham Trent University, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.259195.
Texte intégralBUSSEY, CECILE. « Composes bifonctionnels derives du psoralene : synthese et activite cutanee ». Université Louis Pasteur (Strasbourg) (1971-2008), 1992. http://www.theses.fr/1992STR13098.
Texte intégralLivres sur le sujet "Psoraleni"
P, Gasparro Francis, dir. Psoralen DNA photobiology. Boca Raton, Fl : CRC Press, 1988.
Trouver le texte intégralNational Toxicology Program (U.S.) et National Cancer Institute (U.S.), dir. Photobiologic, toxicologic, and pharmacologic aspects of psoralens. Bethesda, Md : U.S. Dept. of Health and Human Services, Public Health Service, National Institutes of Health, National Cancer Institute, 1986.
Trouver le texte intégralUgent, Steven Jay. Antisense oligonucleotides : Psoralen photoreactivity and enzymatic resistance. [S.l : s.n.], 1991.
Trouver le texte intégralB, Fitzpatrick T., dir. Psoralens : Past, present and future of photochemoprotection and other biological activities : proceedings of the International Congress "Psoralens in 1988", Paris (France) April 15th-16th 1988. London : John Libbey Eurotext, 1989.
Trouver le texte intégralHeidel, Bonnie L. Survey for Psoralea hypogaea in the Great Falls Resource Area, Lewistown District, Bureau of Land Management, Montana. Helena, Mont : Montana Natural Heritage Program, 1994.
Trouver le texte intégralExtracorporeal photochemotherapy : Clinical aspects and the molecular basis for efficacy. Austin : R.G. Landes, 1994.
Trouver le texte intégralIARC Working Group on the Evaluation of the Carcinogenic Risk of Chemicals to Humans. Some naturally occurring and synthetic food components, furocoumarins, and ultraviolet radiation. Lyon, France : World Health Organization, International Agency for Research on Cancer, 1986.
Trouver le texte intégralPer, Svendsen, et Hau Jann, dir. Handbook of laboratory animal science. Boca Raton, FL : CRC Press, 1994.
Trouver le texte intégral(Editor), Thomas B. Fitzpatrick, P. Forlot (Editor), M. A. Pasthak (Editor) et F. Urbach (Editor), dir. Psoralens. John Libbey & Co Ltd, 1989.
Trouver le texte intégralGasparro, Francis P. Psoralen DNA Photobiology. Sous la direction de Francis P. Gasparro. CRC Press, 2018. http://dx.doi.org/10.1201/9781351076128.
Texte intégralChapitres de livres sur le sujet "Psoraleni"
Fassihi, Hiva. « Psoralens ». Dans Handbook of Systemic Drug Treatment in Dermatology, 220–27. 3e éd. London : CRC Press, 2022. http://dx.doi.org/10.1201/9781003016786-32.
Texte intégralBährle-Rapp, Marina. « Psoralene ». Dans Springer Lexikon Kosmetik und Körperpflege, 460. Berlin, Heidelberg : Springer Berlin Heidelberg, 2007. http://dx.doi.org/10.1007/978-3-540-71095-0_8630.
Texte intégralDall’Acqua, F. « Psoralens : A Review ». Dans Photosensitisation, 269–78. Berlin, Heidelberg : Springer Berlin Heidelberg, 1988. http://dx.doi.org/10.1007/978-3-642-73151-8_38.
Texte intégralForlot, Paul E. « Pigmentogenic Effects of Psoralens ». Dans Photosensitisation, 241–44. Berlin, Heidelberg : Springer Berlin Heidelberg, 1988. http://dx.doi.org/10.1007/978-3-642-73151-8_33.
Texte intégralWagner, Hildebert, Rudolf Bauer, Dieter Melchart et Anton Staudinger. « Fructus Psoraleae – Buguzhi ». Dans Chromatographic Fingerprint Analysis of Herbal Medicines Volume IV, 47–57. Cham : Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-32328-2_6.
Texte intégralMcKenna, K. E. « PUVA, Psoralens and Skin Cancer ». Dans Skin Cancer and UV Radiation, 416–24. Berlin, Heidelberg : Springer Berlin Heidelberg, 1997. http://dx.doi.org/10.1007/978-3-642-60771-4_46.
Texte intégralAzimova, Shakhnoza S., et Anna I. Glushenkova. « Psoralea bituminosa L. » Dans Lipids, Lipophilic Components and Essential Oils from Plant Sources, 597. London : Springer London, 2012. http://dx.doi.org/10.1007/978-0-85729-323-7_1952.
Texte intégralAzimova, Shakhnoza S., et Anna I. Glushenkova. « Psoralea corylifolia L. » Dans Lipids, Lipophilic Components and Essential Oils from Plant Sources, 597. London : Springer London, 2012. http://dx.doi.org/10.1007/978-0-85729-323-7_1953.
Texte intégralAzimova, Shakhnoza S., et Anna I. Glushenkova. « Psoralea drupaceae Bunge. » Dans Lipids, Lipophilic Components and Essential Oils from Plant Sources, 597–98. London : Springer London, 2012. http://dx.doi.org/10.1007/978-0-85729-323-7_1954.
Texte intégralKhare, C. P. « Psoralea corylifolia Linn. » Dans Indian Medicinal Plants, 1. New York, NY : Springer New York, 2007. http://dx.doi.org/10.1007/978-0-387-70638-2_1295.
Texte intégralActes de conférences sur le sujet "Psoraleni"
Cheplya, V. S., et S. N. Shahab. « QUANTUM CHEMICAL ANALYSIS OF THE SORPTION INTERACTION BETWEEN PSORALENE AND CARBON DIOXIDE (II) ». Dans SAKHAROV READINGS 2021 : ENVIRONMENTAL PROBLEMS OF THE XXI CENTURY. International Sakharov Environmental Institute, 2021. http://dx.doi.org/10.46646/sakh-2021-1-358-360.
Texte intégralGasparro, Francis P. « Psoralen photobiology and photochemotherapy : perspectives and prospects ». Dans SPIE Institutes for Advanced Optical Technologies 6, sous la direction de Charles J. Gomer. SPIE, 1990. http://dx.doi.org/10.1117/12.2283677.
Texte intégralJacques, Steven L., Lisa A. Buckley, Scott A. Prahl et Kenton W. Gregory. « Quantifying psoralen in tissues by fluorescence : dosimetry for psoralen administration followed by ultraviolet A irradiation (PUVA) to block restenosis ». Dans OE/LASE '94, sous la direction de George S. Abela. SPIE, 1994. http://dx.doi.org/10.1117/12.179911.
Texte intégralBryantseva, Natalya G. « Photophysical and spectral properties of new psoralen photosensitizers ». Dans SPIE Proceedings, sous la direction de Valery V. Tuchin. SPIE, 2006. http://dx.doi.org/10.1117/12.697353.
Texte intégralBryantseva, N. G., et I. V. Sokolova. « Theoretical investigation of absorption spectra from excited states of psoralens ». Dans SPIE Proceedings, sous la direction de Gelii A. Zherebtsov et Gennadii G. Matvienko. SPIE, 2006. http://dx.doi.org/10.1117/12.675192.
Texte intégralLysenko, Eugene P., Alla A. Kyagova et Alexander Y. Potapenko. « Mechanism of photobiological effects of psoralens : the involvement of photo-oxidized psoralens as reactive intermediate species in induction of photosensitized hemolysis and skin erythema ». Dans Saratov Fall Meeting 2001, sous la direction de Valery V. Tuchin. SPIE, 2002. http://dx.doi.org/10.1117/12.475620.
Texte intégralRocha, M. S., et O. N. Mesquita. « Variation of entropic elasticity of DNA-Psoralen complex under UV light ». Dans Optics & Photonics 2005, sous la direction de Kishan Dholakia et Gabriel C. Spalding. SPIE, 2005. http://dx.doi.org/10.1117/12.619128.
Texte intégralKyagova, Alla A., Mekhriban I. Ismailova, Mikhail V. Malakhov et Alexander Y. Potapenko. « Hemolysis induced by psoralen previously photo-oxidized in ethanol or aqueous solutions ». Dans SPIE Proceedings, sous la direction de Valery V. Tuchin. SPIE, 2004. http://dx.doi.org/10.1117/12.578949.
Texte intégralKotzerke, J., R. Runge, T. Rosenberg, R. Freudenberg et C. Brogsitter. « Psoralen als Photosensitizer für die Photodynamische Therapie mit Cherenkov-Licht in vitro ». Dans 60. Jahrestagung der Deutschen Gesellschaft für Nuklearmedizin. Georg Thieme Verlag KG, 2022. http://dx.doi.org/10.1055/s-0042-1746000.
Texte intégralBuckley, Lisa A., Kenton W. Gregory, Deborah T. Bahlman, HanQun Shangguan, Henner Fahrenbach, Eli Rosenthal et Peter C. Block. « Photochemotherapy of intimal hyperplasia using psoralen activated by uv light in porcine model ». Dans Photonics West '96, sous la direction de R. Rox Anderson. SPIE, 1996. http://dx.doi.org/10.1117/12.239996.
Texte intégralRapports d'organisations sur le sujet "Psoraleni"
Shi, Yun-bo. Photochemistry of psoralen-DNA adducts, biological effects of psoralen-DNA adducts, applications of psoralen-DNA photochemistry. Office of Scientific and Technical Information (OSTI), mars 1988. http://dx.doi.org/10.2172/5069947.
Texte intégralSpielmann, Peter Hans. The application of psoralens to the study of DNA structure, function and dynamics. Office of Scientific and Technical Information (OSTI), avril 1991. http://dx.doi.org/10.2172/10115059.
Texte intégralMateeva, Valeria, Doncho Etugov et Grisha Mateev. Efficacy of Systemic PUVA (Psoralen Plus Ultraviolet Light-A) in Bulgarian Patients with Mycosis Fungoides. "Prof. Marin Drinov" Publishing House of Bulgarian Academy of Sciences, novembre 2018. http://dx.doi.org/10.7546/crabs.2018.11.15.
Texte intégralPerera, Anthonige. Genes Affecting the Repair and Survival of Escherichia coli Following Psoralen-Induced Damage : a DNA Interstrand Crosslinking Agent. Portland State University Library, janvier 2000. http://dx.doi.org/10.15760/etd.2192.
Texte intégralCheng, S. Repair of psoralen crosslinks in Escherichia coli : In vitro studies with the RecA protein and (A)BC excinuclease. Office of Scientific and Technical Information (OSTI), mai 1990. http://dx.doi.org/10.2172/7192240.
Texte intégralLivingstone, Dena. The Role of Translesion DNA Polymerase(s) in the Survival of Escherichia Coli Exposed to UVA Light in the Presence of Psoralen and Angelicin. Portland State University Library, janvier 2015. http://dx.doi.org/10.15760/honors.199.
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