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1
Ranc, Anne-Gaëlle. « Phenol Soluble Modulins et lipopolysaccharide de Legionella pneumophila : rôle dans la réponse immunitaire innée ». Thesis, Lyon, 2018. http://www.theses.fr/2018LYSE1010/document.
Texte intégralRésumé :
Legionella pneumophila (Lp) est une bactérie ubiquitaire dans les environnements aqueux et responsable d’une pneumopathie potentiellement sévère : la légionellose. La majorité des souches impliquées appartiennent au sérogroupe 1 (Lp1) et à un sous- groupe spécifique de souches portant un épitope particulier dites mAb3/1+. Cependant, la différence de distribution entre les souches retrouvées dans l’environnement et celles impliquées en clinique n’est pas clairement élucidée. Notre travail a porté sur la détection de deux facteurs de virulence de Lp. Nous avons voulu mettre en évidence l’existence de Phenols Soluble Modulines (PSMs), peptides uniquement décrit chez Staphylocoques et avons ainsi pu démontrer l’activité de peptides prédits par analyse in silico chez Lp capables d’activer la réponse inflammatoire par la voie du NF-?B et sont dotés d’une action cytotoxique. Notre deuxième axe d’étude a porté sur le lipopolysaccharide (LPS) de Lp. Afin de vérifier si la prédominance de certaines souches était liée à un biais diagnostique, nous avons voulu tout d’abord vérifier la sensibilité de 3 tests urinaires diagnostiques envers le LPS extrait de souches de différents sous- groupes de Lp1 et sérogroupes de Lp et avons ainsi pu montrer que ces tests sont capables de détecter tous les LPS de Lp1. La sensibilité envers le LPS des autres sérogroupes est très variable mais reste insuffisante pour permettre leur détection. Nous avons ensuite utilisé ces LPS extraits pour vérifier la réponse immunitaire innée en fonction des souches de Lp1. Ainsi les souches mAb3/1+ activent moins le système immunitaire que les souches mAb3/1-, ce qui pourrait expliquer alors une moins bonne clairance de ces souches permettant leur multiplication à l’origine d’une infection. Au final, notre travail a permis d’étudier deux facteurs de virulence potentiels au sein de Lp, pouvant expliquer partiellement la prédominance de certaines souches en pathologie humaineLegionella pneumophila (Lp) is a ubiquitous intracellular bacterium found widely in the environment and is the cause of an opportunistic infection named legionellosis. The majority of the strains involved belong to serogroup 1 (Lp1) and to a specific subgroup named mAb3/1+, linked to a specific epitope expressed at the cell membrane. However the distribution difference between the strains found in the environment and the ones involved in pathology is not fully understood. We here studied two virulence factors of Lp. We first demonstrated the existence of Phenols Soluble Modulines (PSMs), smalls peptides that only have been described for Staphylococcus and found that the peptides that were predicted for Lp by in silico analysis were able to activate the innate immune response by NF-?B pathway and were able to have a cytotoxic activity. We also studied the lipopolysaccharide (LPS) of Lp. To found out if the predominance of some strains was linked to a diagnosis biais, we first evaluated the sensitivity of 3 urinary antigens tests against extracted LPS of strains belonging to all the sous-groups of Lp1 and serogroups of Lp. We then demonstrated that those tests are able to detect all LPS of Lp1, independently of mAb3/1 character. The sensitivities of the 3 tests were very variable for the other serogroups of Lp, but were too low to be able to detect those LPS in practice. We then used these extracted LPS to evaluate the innate immune response for different strains of Lp1. We demonstrated that mAb3/1- strains needed lower dose of LPS to activate the innate immune response than mAb3/1+ strains, which could be linked to a better clearance of the bacteria from the host, which doesn’t develop an infection. This work has studied two potentially virulent factors of Lp, which could partially explain the predominance of some strains of Lp in human pathology
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Mazánová, Veronika. « Short Crack Growth in Materials for High Temperature Applications ». Doctoral thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2019. http://www.nusl.cz/ntk/nusl-409084.
Texte intégralRésumé :
Pokročilá vysoce legovaná austenitická nerezová ocel Sanicro 25 s Fe-Ni-Cr matricí byla studována za podmínek nízkocyklové únavy za pokojové a vysoké teploty 700 °C. Široká škála moderních experimentálních technik byla použita ke studiu vzájemně souvisejících efektů chemického složení slitiny, mikrostrukturních změn a deformačních mechanismů, které určují odolnost materiálu vůči poškození. Hlavní úsilí bylo zaměřeno na studium iniciace únavových trhlin a růstu krátkých trhlin, tedy dvě stádia, která hrají zásadní roli ve výsledné celkové délce únavového života materiálu v provozu. • Vnitřní deformační mechanismy byly korelovány s vývojem povrchového reliéfu, který je pozorován ve formě persistentních skluzových stop na povrchu. Bylo zjištěno, že vysoce planární charakter dislokačního skluzu způsobuje vysokou lokalizaci cyklické plastické deformace do persistentních skluzových pásů, což v důsledku vede k nukleaci “Stage I” trhlin, která je spojena s přítomností persistentních skluzových stop na povrchu ve všech studovaných vzorcích. Bylo zjištěno, že praskání dvojčatových hraníc je taktéž spojeno s přítomností persistentních skluzových stop podél povrchové stopy dvojčatové roviny. • Interkrystalická iniciace únavové trhliny byla pozorována pouze zřídka, a to za podmínek zatěžování amplitudami vysoké deformace. Bylo zjištěno že interkrystalická iniciace je spojena s přítomností persistentních skluzových stop na hranicích zrn. Hranice zrn praskají za podmínek externího tahového zatížení zejména z důvodu vysokého počtu nekompatibilit na hranicích zrn, které jsou způsobené tvarem persistentních skluzových stop. • Mechanismy růstu přirozených krátkých trhlin byly studovány na vzorcích vystavených nízkocyklove únava s nízkou i vysokou deformací. Role mikrostruktury byla analyzována pomocí experimentálních technik a diskutována. • Rychlosti šíření nejdelších trhlin byly měřeny na vzorcích s mělkým vrubem. Výsledky byly analyzovány použitím přístupů lomové mechaniky založených na amplitudě KI a J-integrálu stejně jako na amplitudě plastické deformace. Všechny přístupy byly diskutovány v souvislosti s Mansonovými-Coffinovými křivkami únavové životnosti. Jednoduchý mocninový zákon růstu krátkých trhlin založený na amplitudě plastické deformace ukazuje velice dobrou korelaci se zákonem únavové životnosti. • Byla studována role oxidace v podmínkách cyklického zatěžování za vysokých teplot. Bylo zjištěno, že křehké praskání zoxidovaných hranic zrn hraje hlavní roli v počátečních stádiích nukleace trhlin. Později po iniciaci se dráha růstu trhliny mění preferenčně na transkrystalickou. Dráha šíření trhlin je velmi podobná dráze zjištěné při cyklování za pokojové teploty.
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Zhang, Jueman (Mandy). « Making online HIV/AIDS PSAs more effective ». Related electronic resource : Current Research at SU : database of SU dissertations, recent titles available full text, 2009. http://wwwlib.umi.com/cr/syr/main.
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Ng, Pauline Crystal. « PSSMs : not just roadkill on the information superhighway / ». Thesis, Connect to this title online ; UW restricted, 2002. http://hdl.handle.net/1773/8116.
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Grosof, Isaac (Isaac B. ). « Secure communication : CDS, PIR, PSM ». Thesis, Massachusetts Institute of Technology, 2017. http://hdl.handle.net/1721.1/113150.
Texte intégralRésumé :
Thesis: M. Eng., Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, 2017.This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.
Cataloged from student-submitted PDF version of thesis.
Includes bibliographical references (pages 52-53).
Private Information Retrieval is the problem of querying two servers to nd a value in a database, while keeping the index private. We extend this problem to Generalized Wildcard PIR, where we instead query an aggregate of the entries whose indices match a pattern, called a generalized wildcard, which species what values each segment of the indices may take. We give a construction for this variant with similar communication to that of the best PIR protocols known. We study information theoretic models in cryptography, namely Private Information Retrieval, Conditional Disclosure of Secrets, and Private Simultaneous Messages. We give extensions of PIR and CDS in the area of generalized wildcards, and give constructions for those extensions. We discuss directions towards more ecient protocols, and raise open questions.
by Isaac Grosof.
M. Eng.
6
Woythal, Nadine [Verfasser]. « In vitro Validierung der in vivo PSMA-Expression in der 68Ga-PSMA-PET/CT beim primären Prostatakarzinom durch die Immunohistochemie / Nadine Woythal ». Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2019. http://d-nb.info/1179778480/34.
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Causey, Charles Lawson. « The Effects of PSAS on Trust in Romantic Relationships ». W&M ScholarWorks, 2006. https://scholarworks.wm.edu/etd/1539720284.
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Saunders, Paige F. « Targeting Functions : A New Approach to Anti-Smoking PSAs ». The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1308241861.
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Wang, Linghan. « Race Moderates the Motivational Processing of Anti-Smoking PSAs ». The Ohio State University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=osu1397734531.
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Nosrati, Kamyar. « Substation Reliability Analysis Using PSS/E ». Thesis, KTH, Electromagnetic Engineering, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-48118.
Texte intégralRésumé :
This report documents an MSc Thesis work of sub-transmission reliability study using PSS/Eperformed at Vattenfall. The network that is examined in this thesis is a sub-transmission network.Vattenfall Distribution Sweden is going to invest and rebuild the network in their 70 and 130 kVmeshed sub transmission network. To invest and rebuild in a network is very expensive. The gridowners want a reliable system that has a high reliability at a low cost.The main focus in this thesis is to examine different substation layouts. Calculating the failureintensities and unavailability for the different substation layouts gives the opportunity to do a life cyclecosts (LCC) on the different substations. With help of LCC calculations it is possible to find thesubstation that gives the lowest cost during a life time. Choosing right equipment in the grid will helpthe Vattenfall network company lower their equipment costs.The thesis work consists of mainly three parts as follows. Network modeling in PSS/EA subset of the existing sub transmission network was used in the project. This subset was taken outfrom the complete network model and modeled in PSS/E. Validation of PSS/E reliability modulesPSS/E reliability modules were new and have not been used earlier by the Vattenfall networkcompany. To be sure that the program calculates correctly a validation was performed. The main focusof the validation has been in looking if the program calculates the interrupted power correctly. Reliability analysis of different substation layoutsFor each of the substation layout the reliability was calculated. On component level (e.g. breaker,disconnector) different types of configuration were studied. To find out the best layout from aneconomical point of view a LCC calculation was also performed.The LCC calculation on the different substation layouts showed that the investment costs affect theresult very much. When the active power through the substation is low it is preferred to use asubstation that has low investment costs. At active power that is 30 MW or higher it is preferred to usethe substation with higher reliability (having higher investment cost). The result shows that using acombined breaker and disconnector instead of circuit breaker could lower the failure intensity andunavailability of substations.
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Kowalkowski, Christian, et Daniel Kindström. « Value visualization strategies for PSS development ». Linköpings universitet, Industriell marknadsföring och industriell ekonomi, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-59921.
Texte intégralRésumé :
The concept of value visualization is concerned with the way that firms communicate and demonstrate the value of their product-service systems (PSS), both internally and externally. In this chapter, a visualization strategy framework for PSS development is proposed. It is particularly tailored for industrial companies that are strategically shifting from selling products to becoming providers offering PSS. Value visualization strategies have traditionally focused on external sales activities. However, companies need to have a broader approach to visualization in all PSS development phases, as well as including different visualization techniques. Furthermore, different visualization strategies are needed for each particular development stage of the PSS. Companies need be able to make use of several different visualization strategies, depending on the actual content of the product-service system and its position in the development process. Whereas the product development process is rather heavy at the back, successful PSS development projects with high levels of service need to be heavy at the front (that is, they need to not only develop the system but also ensure its rollout). Examples are provided from eight market-leading companies in different industries, each of which are undertaking a strategic shift from identifying as product sellers toward becoming providers offering PSS. To conclude, value visualization has become vital for winning new contracts and retaining existing ones. It is therefore a strategic resource that managers need to pay attention to, and continuously develop, in order to compete with PSS offerings.Original Publication: Christian Kowalkowski and Daniel Kindström, Value visualization strategies for PSS development, 2009, Chapter in: Introduction to Product/Service-System Design, 159-182, Eds T. Sakao and M. Lindahl. http://dx.doi.org/10.1007/978-1-84882-909-1_8 Copyright: Springer http://www.springerlink.com/
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Qie, Lili. « Performance Improvement of Latex-based PSAs Using Polymer Microstructure Control ». Thesis, Université d'Ottawa / University of Ottawa, 2011. http://hdl.handle.net/10393/19727.
Texte intégralRésumé :
This thesis aims to improve the performance of latex-based pressure-sensitive adhesives (PSAs). PSA performance is usually evaluated by tack, peel strength and shear strength. Tack and peel strength characterize a PSA’s bonding strength to a substrate while shear strength reflects a PSA’s capability to resist shear deformation. In general, increasing shear strength leads to a decrease in tack and peel strength. While there are several commercial PSA synthesis methods, the two most important methods consist of either solvent-based or latex-based techniques. While latex-based PSAs are more environmentally compliant than solvent-based PSAs, they tend to have much lower shear strength, at similar tack and peel strength levels. Therefore, the goal in this thesis was to greatly improve the shear strength of latex-based PSAs at little to no sacrifice to tack and peel strength.
In this study, controlling the polymer microstructure of latexes or their corresponding PSA films was used as the main method for improving the PSA performance. The research was sub-divided into four parts. First, the influence of chain transfer agent (CTA) and cross-linker on latex polymer microstructure was studied via seeded semi-batch emulsion polymerization of butyl acrylate (BA) and methyl methacrylate (MMA). Three techniques were used to produce the latexes: (1) adding CTA only, (2) adding cross-linker only, and (3) adding both CTA and cross-linker. It was found that using CTA and cross-linker simultaneously allows one to expand the range of latex microstructural possibilities. For example, latexes with similar gel contents but different Mc (molecular weight between cross-links) and Mw (molecular weight of sol polymers) could be produced if CTA and cross-linker concentration are both increased. However, for the corresponding PSAs with similar gel contents, the relationship between their polymer microstructure and performance was difficult to establish as almost all of the medium and high gel content PSAs showed very low tack and peel strength as well as extremely large shear strength readings.
In the second part of this thesis, in order to improve the tack and peel strength of medium and high gel content PSAs, the monomer composition and emulsifier concentration were varied. It was found that changing the monomer mixture from BA/MMA to BA/acrylic acid (AA)/2-hydroxyethyl methacrylate (HEMA) while simultaneously decreasing emulsifier concentration dramatically improved the corresponding PSAs’ shear strength as well as tack and peel strength. The addition of polar groups to the PSA increased its cohesive strength due to the presence of strong hydrogen bonding; meanwhile, PSA films’ surface tension increased.
In the third part, two series of BA/AA/HEMA latexes were generated by varying the amounts of CTA either in the absence or presence of cross-linker. The latexes produced in the absence of cross-linker exhibited significantly larger Mc and Mw compared to their counterparts with similar gel contents prepared with cross-linker. The PSAs with the larger Mc and Mw showed much larger shear strengths due to improved entanglements between the polymer chains.
In the final part of the thesis, the performance of the BA/AA/HEMA PSAs was further improved by post-heating. Compared with original latex-based PSAs with similar gel contents, heat-treated PSAs showed not only significantly improved shear strengths, but also much larger tack and peel strengths. The different shear strengths were related to the PSAs’ gel structures, which were discrete in the original PSAs but continuous in the heat-treated PSAs. The improved tack and peel strengths were related to the PSA films’ surface smoothness. During the post-heating process, the PSA polymer flowed, resulting in much smoother surfaces than the original PSA films. In addition, the effect of post-heating was related to the polymer microstructure of the untreated PSAs. Decreasing the amount of very small or very big polymers or simultaneously increasing Mc and Mw could lead to post-treated PSAs with significantly better performance. Moreover, it was found that by optimizing the polymer microstructure of the original latex-based PSAs, it was possible to obtain a treated PSA with similar or even better performance than a solvent-based PSA with similar polymer microstructure.
Our original objective was surpassed: in two cases, not only was shear strength greatly improved, but so were tack and peel strength due to the simultaneous modification of PSA bulk and surface properties.
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Walker, Natalie. « PSMA-1-Doxorubicin Conjugates for Targeted Therapy of Prostate Cancer ». Case Western Reserve University School of Graduate Studies / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=case1554496393458066.
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Feng, Yamiao. « Factors influencing college students’ attitude toward PSAs for recruiting volunteers ». Thesis, Högskolan i Borås, Akademin för bibliotek, information, pedagogik och IT, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:hb:diva-8687.
Texte intégralRésumé :
Background: Public service advertising in China just has two decades years of history and media used for public service advertising mainly focus on print advertising. Compared to commercial advertising, public service advertising is not mature in China whatever in the forms, content variety or media. Chinese internet users have increased rapidly in recent years, so in this situation, the development of online PSAs is especially important. While many researches focus on print media, few are about PSAs on internet. The money of charity organization spent on PSAs is rare, because the donators want their donation spent on important place. So the quality of PSAs is important to attract people’s attention.Purpose: The purpose of this thesis is to investigate the factors influencing college students’ attitude toward online public service advertising for recruiting volunteers.Method: A quantitative method is taken in this thesis. The primary data are collected through questionnaire and the sample is college students in university in Shanghai for science and technology. The secondary data come from mainly E-library, E-journal and books. To analyze the data, hypothesis testing method is used and SPSS is used as statistical analysis tool.Conclusions: Entertainment, informativeness, irritation, credibility and advertising value these factors from Ducoffe’s model are applied to the research on attitude toward PSAs. The result shows that factors of entertainment, informativeness and advertising value have positive influence on college students’ attitude, while factors of irritation and credibility don’t have influence on college students’ attitude toward volunteer recruitment PSAs, thus they have a nearly neutral attitude. Entertainment and informativeness have significant correlation with advertising value separately, and this situation can also be applied to attitude toward PSAs. Advertising value has significant correlation with attitude toward PSAs. So the Ducoffe’s model is not totally appropriate for the research on attitude toward PSAs.
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Neves, Aline da Silva Boschi Martins. « Evid?ncias de Validade da PSS-10 e PSS- 14 : Estudo com An?lise Fatorial e de Rede ». Pontif?cia Universidade Cat?lica de Campinas, 2018. http://tede.bibliotecadigital.puc-campinas.edu.br:8080/jspui/handle/tede/1093.
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Stress is one of the constructs emphasized when evaluating the health-disease process. However, because it is a latent variable, specific instruments are needed to measure it. The Perceived Stress Scale (PSS) is an instrument that has been used to assess the perception of stress in the last month. Despite numerous validations in several countries, their psychometric properties have not been consensual. The main objective of this work was to investigate the internal structure of the PSS-10 and PSS-14 versions, through exploratory factorial (AFE) and network analysis. Thus, two studies were carried out: in Study I, PSS-10 and PSS-14 were analyzed through AFE and, in study II, the scales were analyzed through network analysis. We used: a) the PSS-10 with a sample composed of 686 participants, being 175 (27.3%) men and 466 (72.7%) women (n = 641), with a mean age of 33.9 SD = 11.3) years, ranging from 18 to 73 (n = 632); and (b) the PSS-14 was answered by 690 participants, of which 304 (44.1%) were men and 386 (55.9.7%) were women, with a mean age of 34.72 (SD = 12, 56), with a range of 18 to 65. In both analyzes, the psychometric properties of PSS-10 and PSS-14 were shown to be reliable and confirmed the two-dimensional structure of distress and coping. Also, the network analysis allowed to explore the PSS in the Brazilian context, allowing new association patterns to emerge from the analyzed samples. And, even AFE being a widely used technique in the construction and evaluation of psychometric tests, network analysis has shown to be a promising and much more comprehensive tool at the level of the symptom, accommodating the numerous processes of psychological constructions. In this study, the network analysis showed how the perception of control influences the outcome of stress. Thus, in addition to providing evidence of validity of the PSS-10 and PSS-14, this study demonstrated how much the network analysis has to contribute in the psychology and health area.
O estresse ? um dos construtos enfatizados quando se avalia o processo sa?de- doen?a. No entanto, por ser uma vari?vel latente, instrumentos espec?ficos s?o necess?rios para mensur?-lo. A Escala de Estresse Percebido (Perceived Stress Scale - PSS) ? um instrumento que tem sido utilizado para avaliar a percep??o do estresse no ?ltimo m?s. Apesar de in?meras valida??es em diversos pa?ses, suas propriedades psicom?tricas n?o t?m sido consensuais. O objetivo principal deste trabalho foi investigar a estrutura interna das vers?es PSS-10 e PSS-14, por meio de an?lise fatorial explorat?ria (AFE) e de rede. Assim, dois estudos foram realizados: no Estudo I, a PSS-10 e a PSS-14 foram analisadas atrav?s da AFE e, no estudo II, analisaram-se as escalas por meio da an?lise de rede. Foram utilizadas: a) a PSS-10 com uma amostra composta por 686 participantes, sendo 175 (27,3%) homens e 466 (72,7%) mulheres (n = 641), com m?dia de idade de 33,9 (SD = 11,3) anos, com amplitude de 18 a 73 (n = 632); e b) a PSS-14 que foi respondida por 690 participantes, dos quais 304 (44,1%) s?o homens e 386 (55,9,7%), mulheres, com m?dia de idade de 34,72 (SD = 12,56) anos, com amplitude de 18 a 65. Nas duas an?lises, as propriedades psicom?tricas da PSS-10 e PSS-14 demonstraram-se confi?veis e confirmaram a estrutura bidimensional de distress e coping. Ainda, a an?lise de rede permitiu explorar a PSS no contexto brasileiro, permitindo que novos padr?es de associa??o emergissem das amostras analisadas. E, mesmo a AFE sendo t?cnica muito utilizada na constru??o e avalia??o de testes psicom?tricos, a an?lise de rede demonstra ser uma ferramenta promissora e muito mais abrangente no n?vel do sintoma, acomodando os numerosos processos das constru??es psicol?gicas. Neste estudo, a an?lise de rede evidenciou o quanto a percep??o de controle influencia no desfecho do estresse. Assim, al?m de fornecer evid?ncias de validade da PSS-10 e PSS-14, este estudo demonstrou o quanto ? an?lise de rede tem a contribuir no ?mbito da psicologia e na ?rea da sa?de.
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Ilis, Lars. « Implementering av en PSS i Trängslets kraftstation ». Thesis, Uppsala universitet, Elektricitetslära, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-209381.
Texte intégralRésumé :
The purpose of this master thesis is to implement and validate a Power System Stabilizer (PSS) to a generator at Trängslet hydropower station in Dalarna, Sweden. Problems with local rotor oscillations can occur at the hydropower station when power is transferred on a new power line (130 kV) from Northern to Southern part of Dalarna. To ensure good operation properties on this power line Fortum Generation AB and Fortum Distribution AB wants to activate a PSS on a generator. There have been investigations in which situations and what equipment that contributes to rotor oscillations. When this is known the PSS is tuned to damp these oscillations by choosing a good set of parameters. The most important parameters for good performance are to choose amount of gain and phase compensation. The chosen set of parameters are verified with a test in the power station to ensure that the task is completed. Test results shows that the magnitude of the first swing in rotor oscillation is almost the double than what PSS/E shows, but good correlation five seconds after initialization of the disturbance. The inherent dampening performance of the generator is much better in reality than in simulation. The chosen set of parameters contributes to rotor oscillation dampening in a magnitude approximately equal to simulation results in PSS/E, why the conclusion has been made that the implementation of the PSS is successful. There has also been made simulations with different power outputs and amount of generators synchronized whose results shows that damping is greatly increased with the chosen PSS.
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Marchner, Bartholomäus [Verfasser], et Dirk [Akademischer Betreuer] Hellwig. « Korrelationsanalyse von PSMA-Expression und Mineralisation in Knochenmetastasen von Prostatakarzinomen in vivo gemessen mit Ga-68-HBED-CC-PSMA-PET/CT / Bartholomäus Marchner ; Betreuer : Dirk Hellwig ». Regensburg : Universitätsbibliothek Regensburg, 2021. http://d-nb.info/1227039654/34.
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Bradbury, Robyn. « The interplay between MDM2 and PSMA in metastatic breast cancer cells ». Thesis, Cardiff University, 2016. http://orca.cf.ac.uk/100068/.
Texte intégralRésumé :
Both mouse double minute (MDM2) and prostate-specific membrane antigen (PSMA) are known to be associated with the progressive properties of cancer. Moreover, overexpression of both molecules has been implicated in an increase in the proliferation, migration and invasion of tumour cells. MDM2 is a negative regulator of tumour suppressor of p53 but also is known to play multiple p53-independent roles in many cancer types. PSMA was originally thought to be solely expressed in prostate tissues and overexpression prostatic cancers; however, recently its expression was reported in various other solid tumours, including those of the breast. Our work showed a possible link between these proteins following knockdown of each molecule in breast cancer cell lines, ZR-75.1 and MDA-MB-231, with targeted siRNA molecules. A decrease of MDM2 and PSMA led to a decrease in the proliferative, adhesive, migratory and invasive capacities of the cell lines. Additionally, knockdown of MDM2 and PSMA led to similar changes in secretion of matrix metalloproteinases (MMPs), with decreases in MMP2 and MMP8 being seen from both breast cell lines investigated. It was then seen that a link between the two protein could be mediated through the phosphorylation status of serine 473 on protein kinase B (AKT). PSMA knockdown in both breast cancer cell lines led to a decrease of AKT phosphorylation and thus a decrease in MDM2 serine 188. Additionally, it was found that MDM2 siRNA leads to an increase in c-JUN serine 63 phosphorylation, and that PSMA siRNA can lead to an increase at the same site, depending on the cell line. These results indicate that MDM2, AKT and PSMA may represent a new pathway which could be targeted for therapy for breast tumours and perhaps other types of cancer.
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Aspinall-O'Dea, Mark Kevin. « An investigation of the PsbS protein isolated from spinach chloroplast membranes ». Thesis, University of Sheffield, 2005. http://etheses.whiterose.ac.uk/14485/.
Texte intégralRésumé :
Dissipation of excess light energy in plant photosynthetic membranes plays an important role in the response of plants to the environment, providing short-term balancing between the intensity of sunlight and photosynthetic capacity. The carotenoid zeaxanthin and the photosystem Il subunit PsbS play vital roles in this process, but the mechanism of their action is largely unexplained. This thesis reports a novel procedure for the extraction of the PsbS protein from spinach thylakoids, including a detailed account of the developmental process and characterisation of the isolated protein. The ability of the PsbS protein to bind xanthophyll cycle carotenoids in vitro was assessed, leading to the observation that the isolated protein was able to bind exogenous zeaxanthin, the binding resulting in a strong red shift in the absorption spectrum, and the appearance of characteristic features in the resonance Raman spectrum and a distinct circular dichroism spectrum, indicating pigment-protein, as well as specific pigmentpigment, interaction. A strong shift in the absorption spectrum of PsbS phenylalanine residues after zeaxanthin binding was observed. It is concluded that zeaxanthin binding to PsbS is the origin of the well known energy dissipation-related 535-nm absorption change. The ability of this PsbS-zeaxanthin complex to affect the rate of chlorophyll fluorescence quenching of the major LHcn antenna protein is detailed, revealing an increase in the rate of quenching, whilst the magnitude of quenching remained constant. The altered properties of zeaxanthin and PsbS after in vitro reconstitution and their subsequent effect on LHCnb provide the first direct indication about how they regulate energy dissipation.
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Escudero, Castellanos Alondra. « Radiofármacos oncoteranósticos inhibidores de PSMA dirigidos a la medicina nuclear traslacional ». Tesis de doctorado, Universidad Autónoma del Estado de México, 2020. http://hdl.handle.net/20.500.11799/109500.
Texte intégralRésumé :
El antígeno prostático específico de membrana (PSMA) se expresa normalmente en células epiteliales de la próstata, pero se sobreexpresa en el 95% de los cánceres de próstata metastásicos (mPCa). Es por eso que PSMA es un apropiado objetivo molecular para la obtención de imágenes y radioterapia de mPCa utilizando radiofármacos específicos.
Por otro lado, los radiopéptidos basados en la secuencia Arg-Gly-Asp (RGD) muestran una alta afinidad y selectividad por las integrinas α(v)β(3). Como resultado, estos péptidos son útiles para unirse a tumores debido a la sobreexpresión de integrinas en la neovasculatura tumoral. De forma similar, el péptido bombesina (BN) posee alta expresión en etapas tempranas del cáncer prostático (PCa), el cual se une específicamente al receptor de péptido liberador de gastrina (GRPr), que es sobreexpresado en el 84% del PCa humano. GRPr es clínicamente relevante debido a su alta expresión en etapas de PCa temprano.
Los tumores humanos muestran heterogeneidad intrínseca y cambios en el fenotipo durante la progresión de la enfermedad, lo que implica diferentes niveles de expresión de los receptores de la superficie celular. La investigación sobre nuevos productos farmacéuticos heterodiméricos radiomarcados con Lu-177 que interactúen con dos blancos moleculares diferentes en células tumorales es una estrategia para mejorar el rendimiento radioterapéutico.
Este estudio tuvo como objetivo sintetizar y caracterizar dos nuevos radiofármacos heterobivalentes, el 177Lu-iPSMA-RGD y el 177Lu-iPSMA-BN, así como evaluar su potencial para enlazarse a células cancerosas que sobreexpresan PSMA, integrinas α(v)β(3) y GRPr, respectivamente. Los radiofármacos fueron preparados con una pureza radioquímica >98%, demostrando alta estabilidad en suero humano, reconocimiento específico con afinidad adecuada hacia los receptores correspondientes, así como capacidad para inhibir la proliferación de células cancerosas. En el caso de la presencia del péptido RGD, se demostró la capacidad para inhibir la señalización de VEGF (efecto antiangiogénico). En el caso de 177Lu-iPSMA-BN se observó una alta captación tumoral in vivo por las células LNCaP y PC3. Las imágenes de micro-SPECT/CT demostraron la capacidad del heterodímero para dirigirse a los tumores, sin aumentar la captación de forma significativa, comparado con sus monómeros, pero siendo captado por los distintos fenotipos de tumores y por lo tanto en las diferentes etapas del cáncer. Los resultados obtenidos justifican realizar estudios preclínicos adicionales para establecer la eficacia terapéutica de los radiofármacos heterodiméricos.El presente trabajo de tesis de doctorado se realizó en el Laboratorio Nacional de Investigación y Desarrollo de Radiofármacos (LANIDER) adscrito a la Gerencia de Aplicaciones Nucleares en la Salud del Departamento de Materiales Radiactivos en el Instituto Nacional de Investigaciones Nucleares (ININ), México. Se realizó con financiamiento del proyecto CONACyT-A1-S-38087.
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Marques, Caio Augusto Nunes. « Framework para definir modelos de processos específicos de desenvolvimento de PSS ». Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/18/18156/tde-25092018-110733/.
Texte intégralRésumé :
As empresas historicamente voltadas à produção de bens manufaturados têm enfrentado uma série de desafios ao longo das últimas décadas. Notadamente o acirramento da competitividade nos diversos mercados tem contribuído para com que diversos produtos sejam transformados em commodities com qualidade e desempenho similares. A disputa entre os players deixa de ser baseada em liderança tecnológica e tende a se resumir à busca por menores custos de produção. Paralelamente, cresce a consciência em diversos atores da sociedade em relação às questões ambientais e, consequentemente, a pressão sobre as indústrias para que contribuam com a criação de uma sociedade mais sustentável. A criação de pacotes que combinam produtos e serviços para entregar valor em uso ou via realização de uma função é uma estratégia que tem sido estudada para contornar os desafios citados. A criação e oferta de um Sistema Produto-Serviço (PSS – do inglês Product-Service System) por uma empresa de manufatura tem potencial para contribuir nas três perspectivas da sustentabilidade, mas traz alguns desafios. O desenvolvimento de produtos e de serviços deve ser feito de forma integrada, considerando seus relacionamentos e, muitas vezes, o modelo de negócios da empresa acaba sendo modificado. Para contornar os desafios relacionados ao desenvolvimento, existem modelos genéricos de processo de desenvolvimento de PSS propostos para que as empresas definam seus próprios modelos específicos. Esses modelos foram propostos para diferentes contextos de desenvolvimento e normalmente carregam os vieses de seus autores, apresentando pontos fortes e limitações. O presente trabalho tem como objetivo propor um framework para definir modelos de processos específicos de desenvolvimento de Sistemas Produto-Serviço. Para tanto este trabalho utiliza o paradigma do método hipotético-dedutivo e a abordagem metodológica DRM (Design Research Methodology). Os métodos de pesquisa utilizados são: painel de especialistas, linguística de corpus e semântica de frames, focus group, estudo de caso, revisão bibliográfica sistemática e análise de conteúdo. Foi possível obter três contribuições inéditas: um conjunto de 310 atividades-síntese; a análise de 15 modelos de processo de desenvolvimento de PSS; e o framework propriamente dito. As duas primeiras são contribuições à teoria. As atividades-síntese correspondem a todas as atividades de desenvolvimento de PSS previstas nos modelos de processo de desenvolvimento de PSS disponíveis na literatura, constituindo seu estado da arte. A análise dos modelos de processo evidenciou objetivamente os seus diferentes perfis, com cada modelo priorizando determinadas categorias de atividades em detrimento de outras. O framework criado foi testado em dois projetos de desenvolvimento de PSS em duas startups, e constitui uma contribuição aos praticantes nas indústrias, que podem utilizá-lo para definir seus modelos de processos específicos de desenvolvimento de PSS a partir de uma base mais abrangente de atividades que em qualquer um dos 15 modelos genéricos analisados.Companies historically focused on the production of manufactured goods have faced a number of challenges over the past few decades. Notably, the intensification of competitiveness in the various markets has contributed to the transformation of various products into commodities of similar quality and performance. The dispute between players ceases to be based on technological leadership and tends to be limited to the search for lower production costs. At the same time, rises the awareness of various actors in society regarding environmental issues and, consequently, the pressure on industries to contribute to the creation of a more sustainable society. The creation of products and services bundles to deliver value in use or through the performance of a function is a strategy that has been studied to overcome the aforementioned challenges. The creation and offering of a Product-Service System (PSS) by a manufacturing company has the potential to contribute to the three perspectives of sustainability, but it also poses some challenges. The development of products and services must be done in an integrated way, considering their relationships and, often, the company\'s business model has to be changed. In order to overcome the development challenges, there are generic PSS development process models proposed for companies to define their own specific models. These models have been proposed for different development contexts and usually carry the biases of their authors, thus presenting strengths and limitations. The present work aims to propose a framework for defining specific process models to develop Product-Service Systems. For this, this work uses the paradigm of the hypothetical-deductive method and the DRM (Design Research Methodology) methodological approach. The research methods used are: experts\' panel, corpus linguistics and frame semantics, focus group, case study, systematic literature review and content analysis. It was possible to obtain three unpublished contributions: the set of 310 synthesis activities; the analysis of the 15 PSS development process models; and the framework itself. The first two are contributions to theory. The synthesis activities correspond to all the PSS development activities prescribed by the PSS development process models available in the literature, constituting its state of the art. The analysis of the process models objectively evidenced their different profiles, with each model prioritizing certain categories of activities in comparison to others. The framework created was applied to two PSS design project in two startups, being a contribution to practitioners in industries that can use it to define their specific PSS development processes models from a broader base of activities than in any of the 15 generic models analyzed.
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Axelsson, Daniel, et Daniel Olsson. « Utvärdering av olika dynamiska lastmodeller i PSS/E ». Thesis, Högskolan Väst, Avdelningen för Industriell ekonomi, Elektro- och Maskinteknik, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:hv:diva-11630.
Texte intégralRésumé :
Examensarbetet har utförts på uppdrag åt Vattenfall Eldistribution AB. Syftet med att arbetet har varit att skapa förståelse för dynamiska lastmodeller och klargöra hur de fungerar och hur de kan användas i PSS/E. Målen har varit att utföra simuleringar på kortslutningar och motorstart för två lastmodeller. Även beskrivning av grundprinciperna för asynkronmaskinen ingår för att få en koppling mellan simulering och teori. Asynkronmaskinens teori innehåller information om induktion och strömkrafter som är de grundläggande begreppen för asynkronmotorn. Det innehåller även sambanden mellan moment, varvtal, ström och spänning samt beskrivning av motorns ekvivalenta schema. Programmet IMD är ett program som tillhör PSS/E och har använts för att skapa modellen för asynkronmotorn som använts för simuleringarna. Vid utförande av simuleringarna har instruktioner från handledaren använts och även instruktioner från PSS/Es manualer. Simuleringarna har körts på två av PSS/Es inbyggda lastmodeller, en generell lastmodell och en modell för asynkronmotorer. Kortslutning har simulerats på båda modellerna och motorstart har simulerats med modellen för asynkronmaskiner. Kortslutning har simulerats med två olika feltider 0,15 och 0,4 sekunder, motorstart har simulerats med två olika storlekar på transformator 1,5 och 3,0 MVA och även tre olika tröghetstidskonstanter, 0,7, 1,0 och 1,5 MWs/MVA har använts. Vid kortslutning orsakar längre feltid större strömmar och längre återhämtningstid för båda lastmodeller. Vid motorstart påverkar storleken på transformatorn, i MVA, och tröghetstidskonstanten tiden för motorns startförlopp. Större transformator innebär kortare startförlopp på grund av minskat spänningsfall. Större tröghetstidskonstant innebär längre startförlopp. Är man enbart intresserad av själva spänningssänkningens storlek och inte själva förloppet kan motorns startadmittans användas.This bachelor’s thesis has been performed for Vattenfall Eldistribution AB. The purpose of this work has been to create understanding of dynamic load models and clarify how they function and how they can be used. The aim has been to perform simulations on short circuits and motor starts for two different load models. A part of the work is also to describe the basic principles of the induction motor to create a connection between simulation and theory. The theory of the induction motor contains information about the electric induction that is the basic principle of the induction machine. It also contains the correlations between torque, speed, current and voltage and also a description of the equivalent electric circuit. The IMD program is a program connected to PSS/E and it has been used to create the model for the induction motor that has been used for the simulations. The simulations have been based on instructions from the advisor and instructions from the PSS/E manuals. Simulations have been run with two of the built-in load models in PSS/E, one general load model and one model for induction motors. Short circuits have been simulated on both models and motor starts on the induction motor model. Short circuits have been simulated with two different fault durations 0.15 and 0.4 seconds. Motor starts have been simulated with two different transformer sizes 1.5 and 3.0 MVA and three different values of the inertia time constant 0.7, 1.0 and 1.5 MWs/MVA. At short circuit the fault duration causes larger currents and longer recovery times for both load models. At motor start the size of the transformer, in MVA, and the inertia time constant affects the motors starting time. Larger transformer means shorter time because of lesser drop in voltage. A larger inertia time constant means longer time. If only the size of the voltage drop is of interest and not the course of the event, the motors start admittance can be used instead.
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Stargård, Susanna, et Sara Hassan. « The Success Factors of PSS Development : A Transformation of Traditional Manufacturing Companies ». Thesis, Mälardalens högskola, Akademin för innovation, design och teknik, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:mdh:diva-19520.
Texte intégralRésumé :
The competition and increasing customers‘ demands makes traditional manufacturing companies consider new ways of differentiate themselves. One way of doing this is to develop product service system (PSS) solutions. PSS solutions are a total offering, where the customer purchases the use of a solution instead of a physical product. This bachelor thesis within the School of Innovation Design and Engineering at Mälardalen University aims to determine the success factor of PSS development at ICT and AM, which are two traditional Swedish manufacturing companies. To do this, the main challenges of transforming ICT and AM into PSS providers will be identified. The thesis also aims to determine if there is a need for change of performance measurements and key performance indicators (KPIs) to enable this transformation. A theoretical review is presented to help the readers in the understanding of the thesis areas. Interviews at ICT and AM were made to get a view of the situations at the companies considering PSS development. The information gathered at the interviews stated the major challenges of transforming both companies into PSS developers. With the theoretical framework and the stated challenges, an analysis was made to determine the success factors of PSS development.The identified success factors of PSS development were Senior management clarification of strategic intent, Cultural change management, Teamwork culture, Internal communication mechanisms, External communication mechanism, Customer relationship, Motivating breakthrough ideas, Project core competency, Cross-functional collaboration, Cross-functional development, Allocation of resources, Training and education, Knowledge management, Customer satisfaction data, Risk management, Product positioning, Portfolio of product opportunities, Product functional content, Knowledge of market potential, Product service processes, Product environment, Development process, Responsibilities of team members, Concurrent development, Internal task coordination, Organizational readiness for sales, Internal marketing and External marketing.Based on the theoretical framework and interviews a statement was made; it is crucial to change the performance measurement and KPIs if implementing PSS, to support collaboration between departments and contribute to the overall success for the companies.
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Hively, Myiah Hutchens. « The effects of self-efficacy statements in anti-tobacco fear appeal PSAs ». Online access for everyone, 2006. http://www.dissertations.wsu.edu/Thesis/Spring2006/m%5Fhively%5F042706.pdf.
Texte intégral
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Wilson, Jonathan Robert. « Copper and zinc ligands of Pisum sativum and expression of psMT(_A) ». Thesis, Durham University, 1995. http://etheses.dur.ac.uk/5320/.
Texte intégralRésumé :
The gene, PsMT(_A) is highly expressed in the roots of the garden pea, Pisum sativum. The predicted primary structures of homologues of the PsMT(_A) gene from a range of plant species were compared. Common features are amino and carboxyl terminal domains of approximately 20 residues which are rich in cysteine residues many of which are arranged in the cysteine-Xaa-cysteine (Xaa is not a cysteine) motifs characteristic of metallothionein. The greatest degree of sequence conservation between these predicted gene products occurs within the cysteine rich domains. Two principal (most highly represented in the available sample) categories of sequence were identified on the basis of the arrangement of the cysteine residues within the amino termina domain. A secondary structure motif (β-strand) was predicted (using a computer algorithm) to occur in a conserved position in the central domain linking the two cysteine rich domains of these predicted proteins. This feature is not apparent in the structure of metallothioneins from other species. A recombinant GST-PsMT(_A) fusion protein was isolated from crude lysates of Escherichia coli. containing the plasmid pGEX3X with PsMT(_A) coding sequence. When isolated from Escherichia coli cells grown in zinc supplemented media it was demonstrated that zinc was associated with the PsMT(_A) moiety of the fusion protein. In aqueous solution the PsMT(_A) moiety of the fusion protein formed discreet degradation products. The fusion protein was insoluble at concentrations greater than 20 mg ml(^-1) which rendered it unsuitable for a structural study of the putative metal binding site(s) by (^113)Cd NMR. An antibody to the GST- PsMT(_A) fusion protein was characterised and the epitope was found to lie within the GST moiety. Comparison of the arrangement of cysteines in the amino terminal domains with the different domains of mammalian metallothionein suggested that the two principal categories of predicted plant metallothionein- like gene products may have different affinities for zinc. The predicted products of the metallothionein-like gene highly expressed in the leaves of Arabidopsis thali ana (AtMT-t2) and the PsMT(_A) gene are representative of the two principal categories identified by sequence analysis. The AtMT-t2 coding sequence was amplified from an Arabidopsis thaliana leaf cDNA library and cloned into the pGEX3X plasmid to allow expression of the protein as a fusion to GST in Escherichia coli. Zinc was associated with the AtMT-t2 moiety of the fusion protein. The pH of 50 % displacement for the GST-AtMT-t2 fusion protein with respect to zinc was 0.25 pH units lower than that for the GST-PsMT(_A) fusion protein indicating that putative metallothionein-like protein from Arabidopsis thaliana may have a higher affinity for zinc. It is feasible that this difference allows AtMT-t2 to compete with endogenous ligands of zinc more effectively than PsMT(_A). Expression of the AtMT-t2 gene in a zinc metallothionein deficient strain of Synechococcus (in collaboration with Dr. J.S. Turner) partially restored zinc tolerance to the transformed cells. The similarity of the cysteine rich domains of the predicted metallothionein-like proteins with metallothionein and the demonstration of metal binding in vitro suggested that these genes may be metal regulated. The effect of variations in the exogenous concentration of the trace metals copper zinc and iron on the expression of the PsMT(_A) gene in the roots of Pisum sativum seedlings was investigated by northern analysis. Induction of PsMT(_A) expression was seen with increasing iron concentrations up to 2.0 µM iron chelate. At this concentration of iron chelate, and above, expression of PsMT(_A), decreased. At concentrations of copper above 100 nM induction of PsMT(_A) expression was seen. Below 100 nM copper PsMT(_A) expression increased with decreasing copper concentrations. This response has not been reported for metallothioneins from other species and may be significant for the role of PsMT(_A) in root tissue. In the presence of 2.0 µM iron zinc concentrations above 5.0 µM induced expression of PsMT(_A). The response to changes in exogenous metal concentrations was rapid. Complete repression of PsMT(_A) transcription occurred within 1 h of transfer to media supplemented with 2.0 µM iron. To date no translational products of plant metallothionein-like genes (excluding the E(_c) protein from Tritticum aestivum) have been identified in plant tissue. Two copper and one zinc complex were identified following ion exchange chromatography of soluble extracts from roots of Pisum sativum. The quantity' of the zinc complex eluted from the matrix was reduced by the addition of iron chelate to the growth media. There was no consistent change in the quantity of copper complex recovered in response to iron. Two copper and one zinc component of low molecular weight were identified following gel filtration chromatography of the above complexes. Following polyacrylamide gel electrophoresis of extracts from roots of Pisum sativum, labelled in vivo with (^35)S cysteine, a band was identified with the characteristics predicted for the product of the PsMT(_A) gene. On two dimensional polyacrylamide gels a doublet of spots was identified (migrating to a low pH as predicted for PsMT(_A)) in an extract from roots of seedlings grown in media not supplemented with iron which were not observed on gels of extracts from seedlings grown in media supplemented with iron. The identity of these polypeptides was not established by sequence analysis.
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Zhang, Jerry Jiaer. « PSS : a phonetic search system for short text documents ». Thesis, University of British Columbia, 2008. http://hdl.handle.net/2429/5537.
Texte intégralRésumé :
Finding the right information from the increasing amount of data on the
Internet is not easy. This is why most people use search engines because
they make searching less difficult with a a variety of techniques. In this
thesis, we address one of them called phonetic matching. The idea is to look
for documents in a document set based on not only the spellings but their
pronunciations as well. It is useful when a query contains spelling mistakes
or a correctly spelled one does not return enough results. In these cases,
phonetic matching can fix or tune up the original query by replacing some
or all query words with the new ones that are phonetically similar, and
hopefully achieve more hits. We propose the design of such a search system
for short text documents. It allows for single- and multiple-word queries to
be matched to sound-like words or phrases contained in a document set and
sort the results in terms of their relevance to the original queries. Our design
differs from many existing systems in that, instead of relying heavily on a set
of extensive prior user query logs, our system makes search decisions mostly
based on a relatively small dictionary consisting of organized metadata. Our
goal is to make it suitable for start-up document sets to have the comparable
phonetic search ability as those of bigger databases, without having to wait
till enough historical user queries are accumulated.
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LI, XIN, et YUNLEI ZHANG. « New Business Potential while Embedding PSS Concept to Wanxiang ». Thesis, Blekinge Tekniska Högskola, Institutionen för maskinteknik, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:bth-11707.
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Xu, George Jianzhou. « Influence of PSMC and other mineral admixtures on the properties of cement mortar ». Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp02/NQ30300.pdf.
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Williams, Tiffany L. Kole Ryszard. « Modulation of PSMA splice variants using splice switching oligonucleotides in prostate cancer cells ». Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2006. http://dc.lib.unc.edu/u?/etd,268.
Texte intégralRésumé :
Thesis (Ph. D.)--University of North Carolina at Chapel Hill, 2006.Title from electronic title page (viewed Oct. 10, 2007). "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Curriculum in Genetics and Molecular Biology." Discipline: Genetics and Molecular Biology; Department/School: Medicine.
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Tam, Pui-ching Celine, et 譚佩貞. « Resident participation in management of HOS/PSPS courts : problems encountered and possible solutions ». Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1998. http://hub.hku.hk/bib/B31968466.
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Tam, Pui-ching Celine. « Resident participation in management of HOS/PSPS courts : problems encountered and possible solutions / ». Hong Kong : University of Hong Kong, 1998. http://sunzi.lib.hku.hk/hkuto/record.jsp?B21029076.
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Alcarde, Lais Fernanda. « Estudo de radiomarcação com gálio-68 do inibidor de PSMA baseado em ureia - avaliação comparativa de método automatizado e não automatizado ». Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/85/85131/tde-30112016-103604/.
Texte intégralRésumé :
Os métodos para o diagnóstico clínico de câncer de próstata incluem o toque retal e a dosagem do antígeno prostático específico (PSA). Entretanto, o nível de PSA encontra-se elevado em cerca de 20 a 30% dos casos relacionados a patologias benignas, o que resulta em falsos positivos e leva os pacientes a realização de biópsias desnecessárias. O antígeno de membrana prostático específico (PSMA), ao contrário, é sobre expresso no câncer de próstata e encontrado em baixos níveis em órgãos saudáveis. Em razão disso, estimulou-se o desenvolvimento de pequenas moléculas inibidoras do receptor de PSMA, que carreguem agentes de imagem ao tumor e que não sejam prejudicadas pela microvasculatura deste. Estudos recentes sugerem que o quelante HBED-CC contribui intrinsicamente para a ligação do peptídeo inibidor de PSMA baseado em ureia (Glu-ureia-Lys) ao grupo farmacofórico. Este trabalho descreve os estudos de otimização das condições de radiomarcação do PSMA-HBED-CC com 68Ga, utilizando sistema automatizado (módulo de síntese) e método não automatizado, buscando estabelecer uma condição adequada de preparação deste novo radiofármaco, com ênfase no rendimento da marcação e na pureza radioquímica do produto. Também objetivou avaliar a estabilidade do peptídeo radiomarcado em condições de transporte e estudar a distribuição biológica do radiofármaco em camundongos sadios. O estudo dos parâmetros de radiomarcação possibilitou definir um método não automatizado que resultou em alta pureza radioquímica (> 95%), sem a necessidade de purificação do radiomarcado. Já o método de marcação automatizado foi adaptado para utilizar módulo de síntese e software já disponíveis no IPEN, e também resultou em rendimento de síntese elevado (≥ 90%) e superior aos descritos em literatura, com a vantagem associada de maior controle do processo produtivo em atendimento aos requisitos de Boas Práticas de Fabricação. O estudo dos parâmetros de radiomarcação permitiu a obtenção do PSMA-HBED-CC-68Ga com atividade específica superior à utilizada em estudos clínicos publicados (≥ 140,0 GBq/μmol), com estabilidade suficientemente longa, que permitirá o transporte às clínicas para aplicação na obtenção de imagens diagnósticas. Os perfis de biodistribuição e farmacocinético do peptídeo radiomarcado foram compatíveis com os encontrados na literatura. Conclui-se que o PSMA-HBED-CC-68Ga, é uma importante ferramenta de diagnóstico do câncer de próstata por imagem PET, pode ser produzido tanto por método automatizado ou não automatizado, com alta pureza radioquímica, alto rendimento de síntese e estabilidade do radiofármaco.The methods for clinical diagnosis of prostate cancer include rectal examination and the dosage of the prostatic specific antigen (PSA). However, the PSA level is elevated in about 20 to 30% of cases related to benign pathologies, resulting in false positives and leading patients to unnecessary biopsies. The prostate specific membrane antigen (PSMA), in contrast, is over expressed in prostate cancer and founded at low levels in healthy organs. As a result, it stimulated the development of small molecule inhibitors of PSMA, which carry imaging agents to the tumor and are not affected by their microvasculature. Recent studies suggest that the HBED-CC chelator intrinsically contributes to the binding of the PSMA inhibitor peptide based on urea (Glu-urea-Lys) to the pharmacophore group. This work describes the optimization of radiolabeling conditions of PSMA-HBED-CC with 68Ga, using automated system (synthesis module) and no automated method, seeking to establish an appropriate condition to prepare this new radiopharmaceutical, with emphasis on the labeling yield and radiochemical purity of the product. It also aimed to evaluate the stability of the radiolabeled peptide in transport conditions and study the biological distribution of the radiopharmaceutical in healthy mice. The study of radiolabeling parameters enabled to define a non-automated method which resulted in high radiochemical purity (> 95 %) without the need for purification of the labeled peptide. The automated method has been adapted, using a module of synthesis and software already available at IPEN, and also resulted in high synthetic yield (≥ 90%) specially when compared with those described in the literature, with the associated benefit of greater control of the production process in compliance with Good Manufacturing Practices. The study of radiolabeling parameters afforded the PSMA-HBED-CC-68Ga with higher specific activity than observed in published clinical studies (≥ 140,0 GBq/μmol), with a sufficiently long stability, which will enable transport to clinics for use in diagnostic imaging. Biodistribution and pharmacokinetic profiles of the radiolabeled peptide were consistent with those founded in the literature. We concluded that PSMA-HBED-CC-68Ga, important diagnostic tool for prostate cancer imaging with PET, can be produced by either automated or not automated method with high radiochemical purity, high synthetic yield and stability of the radiopharmaceutical.
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Hrag, Margossian. « VALIDATION OF THE PSS/E MODEL FOR THE GOTLAND NETWORKR ». Thesis, KTH, Elektriska energisystem, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-119577.
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The aim of the project is to revise the load flow and dynamic PSS/E models of the Gotland network and validate them against a set of measurements collected during a major disturbance, a three phase short circuit in the 70 kV system. The main task in revising the model is to convert the induction machine models of the wind turbines into user and manufacturer wind turbine models. The validation of the model is divided into two phases. The first is to use the measurements as well as some assumptions on the wind power generation and load distribution from the time of the fault to validate the dynamic behaviour of the system. The second is to use new measurements during a normal operation day. The latter would not be very helpful to illustrate the dynamic behaviour of the system, because of the lack of a major fault that would drastically affect the system, but it would nevertheless be useful to validate the load flow with greater accuracy.
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Akis, B. Ceylan. « Preparation of Pd-Ag/PSS composite membranes for hydrogen separation ». Link to electronic thesis, 2004. http://www.wpi.edu/Pubs/ETD/Available/etd-0430104-113019.
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Yao, Xiao. « Grayscale patterning of PEDOT : PSS films by multi-photon lithography ». Thesis, Kansas State University, 2008. http://hdl.handle.net/2097/780.
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Master of ScienceDepartment of Chemistry
Daniel A. Higgins
Lithography techniques have been widely used to fabricate optical, electronic and optoelectronic devices with sub-micron scale spatial resolution. In the most common lithographic procedures, a light sensitive polymer, called a photoresist, is exposed and developed to form a binary relief pattern on a substrate. The finest features are produced by X-ray or electron-beam methods, both of which are very expensive to employ. Less expensive methods use ultraviolet (UV) light to expose the photoresist through a photomask. The resolution in these methods is somewhat lower and is governed by diffraction of light by the photomask, the quality of the photomask, and by any chemical/physical development steps subsequently employed. Due to the above limitations, we have been investigating direct-write, ablative multiphoton lithography as an alternative method for preparing high-resolution patterns. With this method, near-IR light from an ultrafast pulsed laser source is focused into a polymer film, leading to depolymerization and vaporization of the polymer. Arbitrary binary patterns can be produced by raster scanning the sample while controlling exposure of the film to the laser. Importantly, high-resolution etching of the polymer film is achieved without the use of a photomask and without chemical development steps. While arbitrary patters are easily prepared, it is also possible to prepare three-dimensional (i.e. grayscale) surface relief structures. In this study, ablative multiphoton photolithography is used to prepare binary and grayscale structures in thin films of PEDOT:PSS, an electrically conductive organic polymer blend. A simple kinetic model is proposed to explain the etching process. Data on the power-dependence of polymer etching can be fit to this model and is used to determine the order of the nonlinear optical process involved. The etch depth as a function of laser focus is also investigated and shown to follow the same kinetic model. The results show that three-dimensional (grayscale) patterns can be prepared by modulating either the laser power or the laser focus. Images of several binary and grayscale structures prepared by this method are presented.
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Thornström, Axel. « Strömbegränsare i synkrongeneratorer : En studie av strömbegränsarmodeller i PSS/E ». Thesis, Uppsala universitet, Elektricitetslära, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-282507.
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It is well known that a crucial factor determining the transmission capacity with regards to the voltage stability limit of a stressed power system, is the limitation of field and stator current of overexcited generators. These limiters are commonly referred to as overexcitation limiters (OEL) and stator current limiters (SCL). This thesis investigates the representation of overexcitation limiters and stator current limiters in the Swedish power system and how they could be implemented in the power system simulator PSS/E. Dynamic simulations in PSS/E are performed to investigate and validate differences between model types and parameters. The thesis compares different types of limiters and presents a representative set of parameters based on the documentation and implements them into PSS/E. The result from the study is a recommendation to migrate to limiter model MAXEX2 for generators without stator current limiters. The MAXEX2 model uses an inverse time characteristic which is becoming more common in installed voltage regulators. This feature makes it possible for extended use of generators before limiter action is applied. The MAXEX2 model is also possible to tune into a fixed time delay to represent older types of limiters.
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Asker, Helene, et Maria Backström. « En psykometrisk utvärdering av frågeformulären PSAS-C och APSQ som mått på sömnrelaterad oro ». Thesis, Örebro University, School of Law, Psychology and Social Work, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-9604.
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Vårt syfte med denna studie var att göra en psykometrisk utvärdering av frågeformulären PSAS-C (Pre sleep arousal scale) och APSQ (Anxiety and preoccupation about sleep questionnaire). Teoretiska modeller har kommit fram till att kognitiv uppvarvning och förvrängd subjektiv perception av sömn skapar oro som kan bidra till utveckling av insomni. För att fånga upp oro vid insomni används idag två frågeformulär, PSAS-C och APSQ. Deltagare från en svensk longitudinell studie (n = 2333) ombads att svara på de två formulären. Båda skalorna visade på en god begreppsvaliditet och intern samstämmighet. Faktoranalyser, korrelationer och jämförelser av medelvärden visar att båda frågeformulären har goda psykometriska egenskaper och kan vara till stor nytta som mätinstrument för att fånga upp oro vid insomni.
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Bird, Stefan Charles, et stbird@seatiger org. « Adaptive Techniques for Enhancing the Robustness and Performance of Speciated PSOs in Multimodal Environments ». RMIT University. Computer Science and IT, 2008. http://adt.lib.rmit.edu.au/adt/public/adt-VIT20081027.122244.
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This thesis proposes several new techniques to improve the performance of speciated particle swarms in multimodal environments. We investigate how these algorithms can become more robust and adaptive, easier to use and able to solve a wider variety of optimisation problems. We then develop a technique that uses regression to vastly improve an algorithm's convergence speed without requiring extra evaluations. Speciation techniques play an important role in particle swarms. They allow an algorithm to locate multiple optima, providing the user with a choice of solutions. Speciation also provides diversity preservation, which can be critical for dynamic optimisation. By increasing diversity and tracking multiple peaks simultaneously, speciated algorithms are better able to handle the changes inherent in dynamic environments. Speciation algorithms often require a user to specify a parameter that controls how species form. This is a major drawback since the knowledge may not be available a priori. If the parameter is incorrectly set, the algorithm's performance is likely to be highly degraded. We propose using a time-based measure to control the speciation, allowing the algorithm to define species far more adaptively, using the population's characteristics and behaviour to control membership. Two new techniques presented in this thesis, ANPSO and ESPSO, use time-based convergence measures to define species. These methods are shown to be robust while still providing highly competitive performance. Both algorithms effectively optimised all of our test functions without requiring any tuning. Speciated algorithms are ideally suited to optimising dynamic environments, however the complexity of these environments makes them far more difficult to design algorithms for. To increase an algorithm's performance it is necessary to determine in what ways it should be improved. While all performance metrics allow optimisation techniques to be compared, they cannot show how to improve an algorithm. Until now this has been done largely by trial and error. This is extremely inefficient, in the same way it is inefficient trying to improve a program's speed without profiling it first. This thesis proposes a new metric that exclusively measures convergence speed. We show that an algorithm can be profiled by correlating the performance as measured by multiple metrics. By combining these two techniques, we can obtain far better insight into how best to improve an algorithm. Using this information, we then propose a local convergence enhancement that greatly increases performance by actively estimating the location of an optimum. The enhancement uses regression to fit a surface to the peak, guiding the search by estimating the peak's true location. By incorporating this technique, the algorithm is able to use the information contained within the fitness landscape far more effectively. We show that by combining the regression with an existing speciated algorithm, we are able to vastly improve the algorithm's performance. This technique will greatly enhance the utility of PSO on problems where fitness evaluations are expensive, or that require fast reaction to change.
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Page, N. L. « Development of a Novel PSMA - Driven Gene Therapy for the Treatment of Prostate Cancer ». Thesis, Queen's University Belfast, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.517530.
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Souza, Diego Trindade de. « Origem de genes recentes, uma abordagem com PSSMs deterioradas e arquiteturas de domínio proteico ». Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/95/95131/tde-16012017-170749/.
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A origem dos novos genes é um processo importante para a evolução dos organismos, pois ela fornece fontes singulares para a inovação evolutiva. As abordagens que mostram como esses novos genes surgem e adquirem novas funções no curso da evolução são de fundamental importância, por exemplo, elas podem ajudar a correlacionar mutações com alterações metabólicas, fisiológicas e/ou morfológicas, indicando quais mutações podem ser importantes funcionalmente. Recentemente, uma nova abordagem, nomeada de filoestratigrafia, foi desenvolvida para estabelecer origem evolutiva dos genes. Neste método a emergência de novas sequências de um nó filogenético particular em uma linhagem ancestral-descente é inferida geralmente utilizando algoritmos de similaridade. No presente trabalho, nós fizemos uma pesquisa filoestratigráfica de dois bancos de dados de domínios proteicos, CATH e Pfam, para todas as entradas humanas descrevemos a origem dos domínios e arquiteturas humanas. Também realizamos uma nova abordagem para refinar os resultados por Male-PSI-BLAST, em um estudo de caso dos domínios príons e ADHs. A análise das duas bases de dados mostrou que existiram três períodos importantes de aparecimento de domínios proteicos humanos: a origem do organismo celular, Eucarioto e Euteleostomi, nos quais há um elevado número de surgimento de novos genes na linhagem ancestral-descente de humanos. Quando analisamos o aparecimento de arquiteturas, elas são evidentemente mais recentes que o aparecimento de domínios, embora, em seu conteúdo, possa haver domínios muito antigos misturados com domínios novos. Não notamos nenhuma tendência de acréscimo de novos domínios para arquiteturas que compreendem domínios antigos ou recentes. Para medir o grau de versatilidade de domínio, nós utilizamos a frequência ponderada de bigrama, uma combinação específica de dois domínios adjacentes. O teste de correlação de Spearman mostrou que existe uma baixa correlação negativa entre a idade de domínios e índices de versatilidade. Em um estudo de caso, demonstramos que é possível caracterizar descontinuidades evolutivas nos resultados de Male-PSI-BLAST entre domínios que surgiram a partir de outros. Pela primeira vez, a origem de todos os domínios e arquiteturas proteicas presentes nas bases de dados estudadas foi descrita, fornecendo um cenário evolutivo que pode ser mais explorado a partir das abordagens aqui desenvolvidas.The origin of new genes is an important process for the evolution of organisms because they provide singular sources for evolutionary innovation. The approaches that show how these new genes arise and acquire new functions in the course of evolution are of fundamental importance: they can help to correlate mutations with metabolic, physiological, and morphological changes, indicating which mutations are likely to be functionally important. Recently, a new approach, named phylostratigraphy, was developed to establish the evolutionary origin of the genes. In this method the emergence of novel sequences at a particular phylogenetic node in a descendent-ancestor lineage is infer usually by using the similarity search algorithm. In the present work, we did a phylostratigraphical search of two protein domain databases, CATH and Pfam, for all human entries and depicted the origin of human domains and architectures. We also conducted a new approach to refine results by Male-PSI-BLAST in a case study of prions and ADH\'s domains. The analysis of two databases showed that there are three important periods of appearance of human gene domains: the origin of cellular organism, Eukaryote, and Euteleostomi appear to be important for production of new genes at the ancestor-descendent lineages that lead to the human species. However, when we analyze the appearance of architectures, they are by far more recent than the appearance of domains, although they might contain very ancient domains mixed with recent ones. We did not notice a bias of addition of new domains to architectures comprising either ancient or recent domains. To measure the degree of domain versatility, we used the weighted bigram frequency, where bigram is defined as a specific combination of two adjacent domains. The Spearman correlation test showed that there is a low negative correlation between the age of domains and versatility indexes. In the study of case, we have demonstrated that it is possible to characterize evolutionary ruptures in results of Male-PSI- BLAST between domains that emerged from others. For the first time the origin of all protein domains and architectures was depicted, providing an evolutionary scenario that can be further explored.
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Thibaut, Annika Leonie [Verfasser]. « PSMA im klarzelligen Nierenzellkarzinom : eine neue Option zur Detektion von Metastasen / Annika Leonie Thibaut ». Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2020. http://d-nb.info/1234451190/34.
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Waschan, Julia [Verfasser]. « Wertigkeit der 68Ga-PSMA-PET/CT als Nachsorgeuntersuchung des metastasierten kastrationssensitiven Prostatakarzinoms / Julia Waschan ». Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2021. http://d-nb.info/1241540152/34.
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Paiva, Hélder Filipe Cardoso. « A qualidade das relações e o ajustamento Pessoa-Organização : o papel mediador da motivação para o serviço público ». Master's thesis, Instituto Superior de Ciências Sociais e Políticas, 2020. http://hdl.handle.net/10400.5/20556.
Texte intégralRésumé :
Dissertação de Mestrado em Gestão e Políticas PúblicasPortugal tornou-se num exemplo recente no contexto Europeu pelas políticas de austeridade que implementou em consequência da crise financeira de 2008 e também pelo impacto que essas políticas tiveram nas condições de trabalho e nos trabalhadores em funções públicas. Algumas das consequências dessa crise ainda se refletem atualmente nas condições de trabalho em funções públicas, pelo que, o presente estudo procura saber como podem os gestores públicos manter o ajustamento dos trabalhadores com a organização, através da qualidade das relações desenvolvidas nos seus contextos de trabalho. O objetivo geral deste estudo foi investigar a influência que a qualidade da relação com a liderança e com os colegas de trabalho exercem na perceção de ajustamento pessoa-organização. Pretendeu-se ainda testar se a influência da liderança e dos colegas é mediada pela motivação do trabalhador para o serviço público. Com a aplicação de um questionário online foram recolhidas 263 respostas de trabalhadores que desempenham funções públicas na administração pública portuguesa. Os resultados deste estudo demonstraram que, as trocas Líder-Membro (LMX) e as trocas Membro-Membro (MMX), estão positivamente correlacionadas com a perceção de ajustamento pessoa-organização (POFIT). No entanto, a motivação para o serviço público (PSM), operacionalizada com as dimensões de atracão pela realização de políticas publicas (APM) e compromisso com o interesse publico (CPI), não apresentou um efeito mediador, ao contrário do previsto. Conclui-se assim que a perceção de ajustamento com a organização é sensível a fatores do contexto mais próximo: os líderes podem intervir na manutenção do ajustamento dos trabalhadores e os colegas de trabalho também podem influenciar esta perceção de ajustamento. Face aos resultados obtidos, conclui-se ainda que os conceitos de ajustamento pessoaorganização e de motivação para o serviço público carecem de uma dimensão cultural que integre as várias camadas de valores que determinam a perceção e a conduta de atuação dos trabalhadores em funções públicas.
Portugal became a recent example in the european context due to the successful implementation of austerity policies after the 2008 financial crisis and the impact those policies had on public services and public servants work conditions. Some consequences of this crisis are still reflected today in public organizations, especially on workers general conditions, therefore the present study tries to understand if public managers can maintain workers personorganization fit using a social exchange approach. This study investigated the antecedents of person-organization fit (PO Fit) in public organizations using leader-member exchange theory (LMX) and member-member exchange (MMX). One individual variable was also included to test if public service motivation (PSM) mediated the effect of these contextual factors in the perception of fit with public organizations. An online questionnaire was applied to a sample of 263 public servants from several subsectors of the portuguese public administration. Results demonstrated the direct effects of LMX and MMX on PO Fit, however the mediation effect of PSM was not confirmed when using dimensions of attraction to policy making (APM) and commitment to public interest (CPI). Overall, these findings suggest that perceptions of personorganization fit go beyond the initial perception of newcomers, as initially conceived. Organizational context can change and individuals can also reevaluate their initial assessment based on these changes. This study demonstrated that PO Fit can be affected by work environment relationships. Specifically, public managers can influence the perception of core organizational values of their subordinates, but also co-workers can act as examples for individual assessment of value congruence with the organization. Finally, in a broader scope of analysis, the findings in this study also suggest that person-organization fit and public service motivation theories need to integrate a cultural dimension in order to capture the multilayered, and sometimes conflicting values in play, within public organizations.
N/A
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Keenan, Luke. « Post-synthetic modification of metal-organic frameworks ». Thesis, University of Bath, 2014. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.619226.
Texte intégralRésumé :
Post-synthetic modification (PSM) of metal-organic frameworks (MOFs) has increased in importance in the last decade, as a pathway to access more complex surfaces in the pores and channels of porous coordination polymers. This thesis will describe new examples of tandem PSM processes leading to new functionalised MOFs that are inaccessible by direct synthesis. Chapter 1 introduces metal-organic frameworks (MOFs) and reviews the literature ranging from the basic building blocks to 3-D infinite networks. Post-synthetic modification (PSM) is introduced and a review of recent literature given. The aims of this report are also detailed at the close of the chapter. Chapter 2 contains an investigation into the conversion of primary amino to secondary amino groups in the pores of MOFs via a tandem PSM reaction. The pendent amino groups of [Zn4O(BDC-NH2)3] (IRMOF-3) and [Cr3O(OH)(OH2)2(BDC)3] (MIL-101(Cr)-NH2) were modified to produce secondary amino functionalised groups protruding into the void space. Several crystal structures are described including two obtained for the products of the PSM reaction on IRMOF-3. Nitrogen and carbon dioxide absorption was carried and high selectivity for CO2 over N2 was observed. Chapter 3 describes a new hydrothermal synthetic method of MIL-101(Cr)-NH2 and the modification, post-synthesis, to form halo- and azo dye-functionalised pore surfaces by a tandem diazotisation reaction. Quantitative yields are reported for the conversion to the halogenated frameworks inaccessible by direct synthesis with the analogous dicarboxylic acid. Gas adsorption studies demonstrated increased selectivity for CO2 over N2. Chapter 4 details the synthesis of new MOFs, with the potential for PSM, and crystallographic information is supplied for each new extended structure. The linkers, based on isophthalic acid, (1,3-benzenedicarboxylic acid) functionalised at the 5- position, were investigated with a range of metal salts and the resulting frameworks exposed to PSM reaction conditions where appropriate. By using a mixed ligand stoichiometry in the MOF synthesis reaction, 4,4’-bipy and BPDC have been incorporated into new extended frameworks. A new, simpler, synthetic route to the amino functionalised honeycomb framework [Zn4(BDC-NH2)3(NO3)2(H2O)2] (PNMOF-3) is also reported.
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Oliveira, Dennis [Verfasser], Björn Michael [Akademischer Betreuer] Kampa, Karl-Josef [Akademischer Betreuer] Langen et Frank [Akademischer Betreuer] Müller. « In vivo imaging of brain tumors using the PSMA-selective PET ligands [68Ga]Ga-PSMA-HBED-CC and [18F]DCFPyL in rat glioma models / Dennis Oliveira ; Björn Michael Kampa, Karl-Josef Langen, Frank Müller ». Aachen : Universitätsbibliothek der RWTH Aachen, 2019. http://d-nb.info/1195150741/34.
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Mensah, Kwaku Sarpong. « Improving Stability of Ghana's Power System Using Power System Stabiliser(PSS) ». Thesis, Norges teknisk-naturvitenskapelige universitet, Institutt for elkraftteknikk, 2009. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-12884.
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Stability of a power system is vital for its reliable operation and maintaining system stability has been a big challenge for engineers over the years. One way of improving system stability is the use of power system stabiliser (PSS). Its main function is to add damping to the generator rotor oscillation by modulating the generator excitation so as to develop a component of electrical torque in phase with the rotor speed deviation. In Ghana, two power stations have their generators equipped with PSS but none of the PSS are activated. The main objective of this study is to assess how the stability of the power system of Ghana can be improved by activating the power system stabilizers (PSS) on the excitation system of some of the generating units. To effectively perform the study the following questions had to be answered.To what extent will the activation of the PSS on some generating units affect the overall system dynamic performance?Where in the power system should the PSS be activated?To what extend can the PSS reduces system oscillation? What improvement can be made to the power system to optimise the performance of the PSS?Data of Ghana and the interconnected systems were first collected, reviewed and all the systems were modelled using PSSE program. Steady state stability studies were then performed to identify the inadequacy in the system during steady state operations. Five base cases including peak and average load condition with and without contingency were used for this study. Dynamic stability studies were also carried out by selecting appropriate dynamic models for generators, exciters and governors that best fit the dynamic behaviour of the generating units in the PSSE program. Appropriate PSS models were selected for units equipped with PSS based on manufacturers recommendation. Series of dynamic simulations were carried out to identify the best location and parameter settings for the PSS. Small signal stability studies were also carried out to complement the results obtained from the transient studies using NEVA. There was however a defect in the NEVA program and full results could not be obtained.In conclusion, Ghanas system is likely to experience voltage collapse during a transmission outage on some critical lines at peak period unless some loads are shed. This risk can be reduced by improving the power factor to 0.95 using more reactive power compensating devices (capacitor bank) at the local substation. Transient stability results also show that the best location for the PSS to effectively damped oscillation is Akosombo GS. Inter-area oscillations of 0.5Hz between Ghana and Ivory Coast systems, local-area oscillation of 0.8Hz between the Akosombo units and Aboadze units in Ghana, were effectively damped within 7sec with PSS at Akosombo GS. It is highly recommended that PSS at Akosombo generation station be activated since their application has a positive impact on the dynamic performance of Ghanas system. Steady state stability be improved by correcting the power factor at the local stations and line relay settings reviewed to accommodate the present operating condition. It is also recommended that the PSS be coordinated effectively with the protection and control devices for optimal performanc
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Karl, Ralph. « PSS Center for Independent Living evaluation of the residential service program / ». Online version, 2008. http://www.uwstout.edu/lib/thesis/2008/2008karlr.pdf.
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Rosa, Ellysson Fernandes. « O perfil do public service motivation (psm) de servidores públicos inovadores ». Universidade Federal de Goiás, 2017. http://repositorio.bc.ufg.br/tede/handle/tede/6969.
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This research intended to know the PSM profile of public servants who submitted their innovative projects in the 1st project contest for government managers of Goiás-Brazil in 2012. Considering the importance of motivation in the context of public administration, as well as the pressing need for innovation to respond to the social demands, this research was concerned to understand the relationship of PSM level with the profile of public servants of strategic level considered innovative. Using the t-test, multiple correspondence analysis (MCA) and hierarchical cluster analysis (HCA), it was concluded that the PSM level of innovative public servants is significantly higher than that of public servants in general, compared to a research that is a reference in the subject in Brazil. As for the public servers profile, it was found that most of the results achieved are in agreement with previous studies in the literature that investigated the profile of public servants with high levels of PSM, highlighting the Information Technology Managers to a greater extent.
Esta pesquisa pretendeu conhecer o perfil da motivação do serviço público (PSM) em gestores governamentais goianos que inscreveram seus projetos inovadores no 1º concurso de projetos dos Gestores Governamentais de Goiás em 2012, promovido pelo SINDGESTOR. Considerando a importância da motivação no contexto da administração pública, bem como, a necessidade premente por inovação para dar respostas às demandas sociais, esta pesquisa se ocupou em entender a relação do índice de PSM com o perfil de servidores públicos de nível estratégico considerados inovadores. Utilizando teste t, análise de correspondência múltipla (MCA) e a análise hierárquica de cluster (HCA) concluiu-se que o nível de PSM destes servidores públicos inovadores é significativamente maior do que os servidores públicos em geral em comparação à uma pesquisa que é referência no tema no Brasil. Quanto ao perfil dos servidores descobriu-se que a maior parte dos resultados alcançados está em consonância com estudos anteriores da literatura que pesquisaram sobre o perfil de servidores públicos com alto índice de PSM, destacando os gestores da tecnologia da informação em maior proporção.
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Nielsen, Nikolaj [Verfasser], et Albrecht [Akademischer Betreuer] Schwab. « Function of ion transport proteins in pancreatic stellate cells (PSCs) / Nikolaj Nielsen ; Betreuer : Albrecht Schwab ». Münster : Universitäts- und Landesbibliothek Münster, 2015. http://d-nb.info/1138281395/34.
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Unger, Clara Marie [Verfasser], et Ingolf [Akademischer Betreuer] Juhasz-Böss. « Die Expression des prostataspezifischen Membranantigens (PSMA) beim Mammakarzinom / Clara Marie Unger ; Betreuer : Ingolf Juhasz-Böss ». Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2020. http://d-nb.info/1213724023/34.
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