Littérature scientifique sur le sujet « Protein interactions (PPI) »
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Articles de revues sur le sujet "Protein interactions (PPI)"
CHUA, HON NIAN, KANG NING, WING-KIN SUNG, HON WAI LEONG et LIMSOON WONG. « USING INDIRECT PROTEIN–PROTEIN INTERACTIONS FOR PROTEIN COMPLEX PREDICTION ». Journal of Bioinformatics and Computational Biology 06, no 03 (juin 2008) : 435–66. http://dx.doi.org/10.1142/s0219720008003497.
Texte intégralKusova, Aleksandra M., Aleksandr E. Sitnitsky, Vladimir N. Uversky et Yuriy F. Zuev. « Effect of Protein–Protein Interactions on Translational Diffusion of Spheroidal Proteins ». International Journal of Molecular Sciences 23, no 16 (17 août 2022) : 9240. http://dx.doi.org/10.3390/ijms23169240.
Texte intégralPoot Velez, Albros Hermes, Fernando Fontove et Gabriel Del Rio. « Protein–Protein Interactions Efficiently Modeled by Residue Cluster Classes ». International Journal of Molecular Sciences 21, no 13 (6 juillet 2020) : 4787. http://dx.doi.org/10.3390/ijms21134787.
Texte intégralVelasco-García, Roberto, et Rocío Vargas-Martínez. « The study of protein–protein interactions in bacteria ». Canadian Journal of Microbiology 58, no 11 (novembre 2012) : 1241–57. http://dx.doi.org/10.1139/w2012-104.
Texte intégralKaur, Rajpreet, Poonam Khullar et Anita Gupta. « Protein-Protein Interactions Followed by in-Situ Synthesis of Gold Nanoparticles ». ECS Transactions 107, no 1 (24 avril 2022) : 16375–90. http://dx.doi.org/10.1149/10701.16375ecst.
Texte intégralYang, Lei, et Xianglong Tang. « Protein-Protein Interactions Prediction Based on Iterative Clique Extension with Gene Ontology Filtering ». Scientific World Journal 2014 (2014) : 1–6. http://dx.doi.org/10.1155/2014/523634.
Texte intégralAbdullah, Syahid, Wisnu Ananta Kusuma et Sony Hartono Wijaya. « Sequence-based prediction of protein-protein interaction using autocorrelation features and machine learning ». Jurnal Teknologi dan Sistem Komputer 10, no 1 (4 janvier 2022) : 1–11. http://dx.doi.org/10.14710/jtsiskom.2021.13984.
Texte intégralOrasch, Oliver, Noah Weber, Michael Müller, Amir Amanzadi, Chiara Gasbarri et Christopher Trummer. « Protein–Protein Interaction Prediction for Targeted Protein Degradation ». International Journal of Molecular Sciences 23, no 13 (24 juin 2022) : 7033. http://dx.doi.org/10.3390/ijms23137033.
Texte intégralKlein, Mark. « Targeting Protein-Protein Interactions to Inhibit Cyclin-Dependent Kinases ». Pharmaceuticals 16, no 4 (31 mars 2023) : 519. http://dx.doi.org/10.3390/ph16040519.
Texte intégralZhang, Jinxiong, Cheng Zhong, Hai Xiang Lin et Mian Wang. « Identifying Protein Complexes from Dynamic Temporal Interval Protein-Protein Interaction Networks ». BioMed Research International 2019 (21 août 2019) : 1–17. http://dx.doi.org/10.1155/2019/3726721.
Texte intégralThèses sur le sujet "Protein interactions (PPI)"
Weimann, Mareike. « A proteome-wide screen utilizing second generation sequencing for the identification of lysine and arginine methyltransferase protein interactions ». Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2012. http://dx.doi.org/10.18452/16581.
Texte intégralProtein methylation on arginine and lysine residues is a largely unexplored posttranslational modification which regulates diverse cellular processes. The development of efficient proteome-wide approaches for detecting protein methylation is limited and technically challenging. We developed a novel workload reduced yeast-two hybrid (Y2H) approach to detect protein-protein interactions utilizing second generation sequencing. The novel Y2H-seq approach was systematically evaluated against our state of the art Y2H-matrix screening approach and used to screen 8 protein arginine methyltransferases, 17 protein lysine methyltransferases and 10 demethylases against a set of 14,268 proteins. Comparison of the two approaches revealed a higher sensitivity of the new Y2H-seq approach. The increased sampling rate of the Y2H-seq approach is advantageous when assaying transient interactions between substrates and methyltransferases. Overall 523 interactions between 22 bait proteins and 324 prey proteins were identified including 11 proteins known to be methylated. Network analysis revealed enrichment of transcription regulator activity, DNA- and RNA-binding function of proteins interacting with protein methyltransferases. The dataset represents the first proteome-wide interaction network of enzymes involved in methylation and provides a comprehensively annotated resource of potential new methylation substrates. An in vitro methylation assay coupled to mass spectrometry revealed amino acid methylation of candidate proteins. Seven of nine proteins tested were methylated including SPIN2B, DNAJA3, QKI, SAMD3, OFCC1, SYNCRIP and WDR42A indicating that the interaction network is likely to contain many putative methyltransferase substrate pairs. The presented protein-protein interaction network demonstrates that protein methylation is involved in diverse cellular processes and can inform hypothesis driven investigation into molecular mechanisms regulated through methylation.
Peri, C. « INVESTIGATING AND PREDICTING THE DETERMINANTS OF PROTEIN-PROTEIN INTERACTIONS THROUGH COMPUTATIONAL-STRUCTURAL BIOLOGY APPROACHES : IMPLICATIONS FOR STRUCTURAL VACCINOLOGY ». Doctoral thesis, Università degli Studi di Milano, 2014. http://hdl.handle.net/2434/243392.
Texte intégralWorseck, Josephine Maria. « Characterization of phosphorylation-dependent interactions involving neurofibromin 2 (NF2, merlin) isoforms and the Parkinson protein 7 (PARK7, DJ1) ». Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2012. http://dx.doi.org/10.18452/16533.
Texte intégralAlterations in phosphorylation-dependent signalling pathways, accumulation of aggregated proteins in the brain and neuronal apoptosis are common to neurodegeneration and implicate overlapping molecular mechanism. To gain insight into involved pathways, a modified yeast-two hybrid (Y2H) system was applied to screen 71 proteins associated with neurological disorders in a proteome-wide manner. For 21 of these proteins interactions were identified including 5 phosphorylation-dependent ones. In total, the network connected 79 proteins through 90 protein-protein interactions (PPIs). A fraction of these Y2H PPIs was tested in secondary interaction assays with a validation rate of 66 %. The described network-based approach successfully identified proteins associated with more than one disorder and cellular functions connected to specific disorders. In particular, the network revealed Ser/Thr kinase-dependent PPIs between the Parkinson protein 7 (PARK7, DJ1) and the E3 ligase components ASB3 and RNF31 (HOIP). The function of these proteins further substantiates the established connection between Parkinson’s disease (PD) and ubiquitination-mediated proteasome (dis)functions. Neurofibromin 2 (NF2, merlin) isoforms and PARK7 were identified as PI3K regulatory subunit p55-gamma (PIK3R3) interactors. These PPIs required Tyr kinase coexpression in the modified Y2H system and functional PIK3R3 pTyr-recognition modules (SH2 domains) in co-IP and Venus PCA experiments. This finding implicates the PI3K/AKT survival pathway in PD-associated neuronal apoptosis and Neurofibromatosis type 2-associated tumour formation. Investigation of PIK3R3, AOF2 (KDM1A, LSD1) and EMILIN1 PPIs on NF2 isoform level revealed preferential isoform 7 binding and cytoplasmic or membrane localisation of these PPIs for isoform 7 or 1, respectively. The generated modification-dependent and isoform-specific PPI network triggered many hypotheses on the molecular mechanisms implicated in neurological disorders.
Lima, Leandro de Araujo. « Uma abordagem integrativa usando dados de interação proteína-proteína e estudos genéticos para priorizar genes e funções biológicas em transtorno de déficit de atenção e hiperatividade ». Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/95/95131/tde-24082015-160400/.
Texte intégralAttention-Deficit/Hyperactivity Disorder (ADHD) is the most common neuro-developmental disorder in children, affecting 5.8% of children and adolescents in the world. Many studies have attempted to investigate the genetic susceptibility of ADHD without much success. The present study aimed to analyze rare and common variants contributing to the genetic architecture of ADHD. We generated exome data from 30 Brazilian trios where the children were diagnosed with sporadic ADHD. We analyzed both single-nucleotide variants (SNVs) and copy-number variants (CNVs) in these trios and across multiple datasets, including a Brazilian sample of 503 children/adolescent controls from the High Risk Cohort Study for the Development of Childhood Psychiatric Disorders, and also previously published results of four CNV studies of ADHD involving children/adolescent Caucasian samples. The results from the Brazilian trios showed 3 major patterns: cases with inherited variations and de novo SNVs or de novo CNVs and cases with only inherited variations. Although the sample size is small, we could see that various comorbidities are more frequent in cases with only inherited variants. After exploring the rare variant composition in our 30 cases we selected genes with variations (SNVs or located in CNV regions) in our trio analysis that are recurrent in the families analyzed or in public data sets. Moreover, using only genes expressed in brain (post-mortem samples from Brain Atlas and The Genotype-Tissue Expression project), we constructed an in silico protein-protein interaction (PPI) network, with physical interactions confirmed by at least two sources. Topological and functional analyses of genes in this network uncovered genes related to synapse, cell adhesion, glutamatergic and serotoninergic pathways, both confirming findings of previous studies and capturing new genes and genetic variants in these pathways.
Alleman, Cécile. « Accès synthétique au châssis [5-8-5] de la fusicoccine-A pour la synthèse d’analogues simplifiés en vue d'étudier les interactions protéine-protéine ». Electronic Thesis or Diss., Université de Rennes (2023-....), 2023. http://www.theses.fr/2023URENS090.
Texte intégralIn biological media, protein-protein interactions (PPI) are of huge importance, as they allow the regulation of many cellular events. PPI classically involve two partners: an adapter protein and its effector protein(s) regulated either in a positive or a negative manner. Inhibition of PPI has thus been considered as a solid therapeutic approach. On the other hand, stabilization of PPI remains scarcely investigated, but may lead to new promising approaches. This project focuses on the 14-3-3 family adapter protein which interacts with more than 200 protein partners. Among them, p53 protein is subjected to a lot of studies as this tumor suppressor protein regulates multiple biological processes (DNA repair, apoptosis). However, those major functions appear to be silenced in most cancer cases, thus allowing tumor cells proliferation. Some studies have shown that stabilization of the 14-3-3/p53 pair with the help of a molecular glue permitted to restore tumor suppressor activity of p53. Among the examined molecular glues, the fusicoccin-A (FC-A) natural product is shown to lodge in the valley formed by 14-3-3 and increases stabilization of the 14-3-3/p53 interaction. In this context, to enlarge the p53/14-3-3 molecular glue library, this project focuses on the access to simplified FC-A analogs through the synthesis of tricyclic scaffold. [6-8-5] analogs from an aromatic substrate are envisaged, as well as [5-8-5] analogs from a cyclopentane derivative, closer to the target structure. Various strategies have been explored in order to access these analogs
Gilker, Eva Adeline Gilker. « INTERACTIONS AND LOCALIZATION OF PROTEIN PHOSPHATASES, YWHA PROTEINS AND CELL CYCLE CONTROL PROTEINS IN MEIOSIS ». Kent State University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=kent1532699317257539.
Texte intégralRavindranath, Velaga M. « Elucidating the role of mitoferrin (Mfrn), iron regulatory proteins (IRP1 and IRP2) and hephaestin (Heph) in iron metabolism by tagSNP and protein-protein interaction (PPI) analysis ». Thesis, London Metropolitan University, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.639414.
Texte intégralJohansson-Åkhe, Isak. « PePIP : a Pipeline for Peptide-Protein Interaction-site Prediction ». Thesis, Linköpings universitet, Institutionen för fysik, kemi och biologi, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-138411.
Texte intégralJohansson, Joakim. « Modifying a Protein-Protein Interaction Identifier with a Topology and Sequence-Order Independent Structural Comparison Method ». Thesis, Linköpings universitet, Bioinformatik, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-147777.
Texte intégralSelim, Khaled [Verfasser]. « Structural and Functional Characterization of PII and PII-like Proteins and their Network of Interactions / Khaled Selim ». Tübingen : Universitätsbibliothek Tübingen, 2021. http://d-nb.info/1233678507/34.
Texte intégralLivres sur le sujet "Protein interactions (PPI)"
Winter, Sherry Lynn. Genetic and functional characterization of the interaction of BRCA1 with the serine/threonine phosphatase, PP1, and the circadian clock proteins, Per1 and Per2. 2006.
Trouver le texte intégralChapitres de livres sur le sujet "Protein interactions (PPI)"
Fernholz, Mikayla M., Leonie M. Windeln, Monika Papayova et Ali Tavassoli. « Chapter 6. Genetically Encoded SICLOPPS Libraries for the Identification of PPI Inhibitors ». Dans Inhibitors of Protein–Protein Interactions, 218–31. Cambridge : Royal Society of Chemistry, 2020. http://dx.doi.org/10.1039/9781839160677-00218.
Texte intégralTuncbag, Nurcan, Ozlem Keskin, Ruth Nussinov et Attila Gursoy. « Prediction of Protein Interactions by Structural Matching : Prediction of PPI Networks and the Effects of Mutations on PPIs that Combines Sequence and Structural Information ». Dans Protein Bioinformatics, 255–70. New York, NY : Springer New York, 2017. http://dx.doi.org/10.1007/978-1-4939-6783-4_12.
Texte intégralYang, Xuan, et Andrey A. Ivanov. « CHAPTER 4. Computational Structural Modeling to Discover PPI Modulators ». Dans Protein–Protein Interaction Regulators, 87–108. Cambridge : Royal Society of Chemistry, 2020. http://dx.doi.org/10.1039/9781788016544-00087.
Texte intégralDoyle, Sean P., Xiulei Mo, Kun Qian, Danielle N. Cicka, Qiankun Niu et Haian Fu. « CHAPTER 3. High Throughput Screening Methods for PPI Inhibitor Discovery ». Dans Protein–Protein Interaction Regulators, 49–86. Cambridge : Royal Society of Chemistry, 2020. http://dx.doi.org/10.1039/9781788016544-00049.
Texte intégralSHI, LEI, XIUJUAN LEI et AIDONG ZHANG. « Protein Functional Module Analysis With Protein-Protein Interaction (PPI) Networks ». Dans Algorithmic and Artificial Intelligence Methods for Protein Bioinformatics, 393–411. Hoboken, NJ, USA : John Wiley & Sons, Inc., 2013. http://dx.doi.org/10.1002/9781118567869.ch20.
Texte intégralHolzinger, Andreas, Anna Saranti, Anne-Christin Hauschild, Jacqueline Beinecke, Dominik Heider, Richard Roettger, Heimo Mueller, Jan Baumbach et Bastian Pfeifer. « Human-in-the-Loop Integration with Domain-Knowledge Graphs for Explainable Federated Deep Learning ». Dans Lecture Notes in Computer Science, 45–64. Cham : Springer Nature Switzerland, 2023. http://dx.doi.org/10.1007/978-3-031-40837-3_4.
Texte intégralKapadia, Paritosh, Saudamini Khare, Piali Priyadarshini et Bhaskarjyoti Das. « Predicting Protein-Protein Interaction in Multi-layer Blood Cell PPI Networks ». Dans Communications in Computer and Information Science, 240–51. Singapore : Springer Singapore, 2019. http://dx.doi.org/10.1007/978-981-15-0111-1_22.
Texte intégralGadde, Sai Gopala Swamy, Kudipudi Pravallika et Kudipudi Srinivas. « Evolutionary, Protein–Protein Interaction (PPI), and Domain–Domain Analyses in Huntington’s Disease ». Dans Lecture Notes in Electrical Engineering, 11–23. Singapore : Springer Nature Singapore, 2023. http://dx.doi.org/10.1007/978-981-99-6690-5_2.
Texte intégralAhuja, Khushi, Aditi Joshi, Navjyoti Chakraborty, Ram Singh Purty et Sayan Chatterjee. « Comparative Analysis of Computational Methods used in Protein-Protein Interaction (PPI) Studies ». Dans Computational and Analytic Methods in Biological Sciences, 63–100. New York : River Publishers, 2023. http://dx.doi.org/10.1201/9781003393238-4.
Texte intégralWang, Wei, et Jinwen Ma. « Density Based Merging Search of Functional Modules in Protein-Protein Interaction (PPI) Networks ». Dans Lecture Notes in Computer Science, 634–41. Berlin, Heidelberg : Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-642-14922-1_79.
Texte intégralActes de conférences sur le sujet "Protein interactions (PPI)"
Lv, Guofeng, Zhiqiang Hu, Yanguang Bi et Shaoting Zhang. « Learning Unknown from Correlations : Graph Neural Network for Inter-novel-protein Interaction Prediction ». Dans Thirtieth International Joint Conference on Artificial Intelligence {IJCAI-21}. California : International Joint Conferences on Artificial Intelligence Organization, 2021. http://dx.doi.org/10.24963/ijcai.2021/506.
Texte intégralGhosh, Supratim, Burcu Guldiken, Maxime Saffon et Michael Nickeson. « Improved emulsification behaviour of pea protein-polysaccharide complexes for beverage application ». Dans 2022 AOCS Annual Meeting & Expo. American Oil Chemists' Society (AOCS), 2022. http://dx.doi.org/10.21748/oniy9265.
Texte intégralKralj, Sebastjan, Milan Hodošček, Marko Jukić et Urban Bren. « A comprehensive in silico protocol for fast automated mutagenesis and binding affinity scoring of protein-ligand complexes ». Dans 2nd International Conference on Chemo and Bioinformatics. Institute for Information Technologies, University of Kragujevac, 2023. http://dx.doi.org/10.46793/iccbi23.674k.
Texte intégralZhao, Ziyuan, Peisheng Qian, Xulei Yang, Zeng Zeng, Cuntai Guan, Wai Leong Tam et Xiaoli Li. « SemiGNN-PPI : Self-Ensembling Multi-Graph Neural Network for Efficient and Generalizable Protein–Protein Interaction Prediction ». Dans Thirty-Second International Joint Conference on Artificial Intelligence {IJCAI-23}. California : International Joint Conferences on Artificial Intelligence Organization, 2023. http://dx.doi.org/10.24963/ijcai.2023/554.
Texte intégralUmbrin, Hina, et Saba Latif. « A survey on Protein Protein Interactions (PPI) methods, databases, challenges and future directions ». Dans 2018 International Conference on Computing, Mathematics and Engineering Technologies (iCoMET). IEEE, 2018. http://dx.doi.org/10.1109/icomet.2018.8346326.
Texte intégralMa, Xiaoke, et Lin Gao. « Detecting protein complexes in PPI networks : The roles of interactions ». Dans 2011 IEEE International Conference on Systems Biology (ISB). IEEE, 2011. http://dx.doi.org/10.1109/isb.2011.6033120.
Texte intégralOviya, I. R., Shanmukha Sravya N et Kalpana Raja. « R2V-PPI : Enhancing Prediction of Protein-Protein Interactions Using Word2Vec Embeddings and Deep Neural Networks ». Dans 2024 Fourth International Conference on Advances in Electrical, Computing, Communication and Sustainable Technologies (ICAECT). IEEE, 2024. http://dx.doi.org/10.1109/icaect60202.2024.10469595.
Texte intégral« PREDICTION OF PROTEIN INTERACTIONS ON HIV-1–HUMAN PPI DATA USING A NOVEL CLOSURE-BASED INTEGRATED APPROACH ». Dans International Conference on Bioinformatics Models, Methods and Algorithms. SciTePress - Science and and Technology Publications, 2012. http://dx.doi.org/10.5220/0003769001640173.
Texte intégralDimitrakopoulos, Georgios Ν., Konstantinos Lazaros, Aristidis G. Vrahatis, Marios Krokidis, Konstantina Skolariki, Panagiotis Vlamos et Themis Exarchos. « A Machine Learning approach combining omics data for Alzheimer’s Disease analysis ». Dans 2nd International Conference on Chemo and Bioinformatics. Institute for Information Technologies, University of Kragujevac, 2023. http://dx.doi.org/10.46793/iccbi23.342d.
Texte intégralSoude, Anne, Martine Barth, Stephanie Bocart, Frederic Thoreau, Philippe Masson, Isabelle Braccini, Christian Montalbetti, Pierre Broqua et Claudia Fromond. « Abstract 894 : Discovery of YAP-TEAD protein-protein interaction (PPI) inhibitors for cancer therapy ». Dans Proceedings : AACR 107th Annual Meeting 2016 ; April 16-20, 2016 ; New Orleans, LA. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.am2016-894.
Texte intégralRapports d'organisations sur le sujet "Protein interactions (PPI)"
Avni, Adi, et Gitta L. Coaker. Proteomic investigation of a tomato receptor like protein recognizing fungal pathogens. United States Department of Agriculture, janvier 2015. http://dx.doi.org/10.32747/2015.7600030.bard.
Texte intégralSessa, Guido, et Gregory Martin. role of FLS3 and BSK830 in pattern-triggered immunity in tomato. United States Department of Agriculture, janvier 2016. http://dx.doi.org/10.32747/2016.7604270.bard.
Texte intégralNelson, Nathan, et Charles F. Yocum. Structure, Function and Utilization of Plant Photosynthetic Reaction Centers. United States Department of Agriculture, septembre 2012. http://dx.doi.org/10.32747/2012.7699846.bard.
Texte intégralDickman, Martin B., et Oded Yarden. Modulation of the Redox Climate and Phosphatase Signaling in a Necrotroph : an Axis for Inter- and Intra-cellular Communication that Regulates Development and Pathogenicity. United States Department of Agriculture, août 2011. http://dx.doi.org/10.32747/2011.7697112.bard.
Texte intégralChristopher, David A., et Avihai Danon. Plant Adaptation to Light Stress : Genetic Regulatory Mechanisms. United States Department of Agriculture, mai 2004. http://dx.doi.org/10.32747/2004.7586534.bard.
Texte intégralMorrison, Mark, Joshuah Miron, Edward A. Bayer et Raphael Lamed. Molecular Analysis of Cellulosome Organization in Ruminococcus Albus and Fibrobacter Intestinalis for Optimization of Fiber Digestibility in Ruminants. United States Department of Agriculture, mars 2004. http://dx.doi.org/10.32747/2004.7586475.bard.
Texte intégralWolf, Shmuel, et William J. Lucas. Involvement of the TMV-MP in the Control of Carbon Metabolism and Partitioning in Transgenic Plants. United States Department of Agriculture, octobre 1999. http://dx.doi.org/10.32747/1999.7570560.bard.
Texte intégralYosef, Carlos M. Production of High Transverse Momentum $\pi^0$ Mesons in Interactions of 530 GeV/c Proton and $\pi^-$ Beams on Beryllium and Copper Targets. Office of Scientific and Technical Information (OSTI), janvier 1990. http://dx.doi.org/10.2172/1426709.
Texte intégralRaghothama, Kashchandra G., Avner Silber et Avraham Levy. Biotechnology approaches to enhance phosphorus acquisition of tomato plants. United States Department of Agriculture, janvier 2006. http://dx.doi.org/10.32747/2006.7586546.bard.
Texte intégralChoudhary, Brajesh Chandra. A Study of High Transverse Momentum Direct Photon Production in Interactions of 500 GeV/c $\pi^{-}$ and Proton Beams on a Beryllium Target. Office of Scientific and Technical Information (OSTI), janvier 1991. http://dx.doi.org/10.2172/1372873.
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