Articles de revues : « PREPOST SELECTOR »

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Hayden, James E. « A Shoemaker Butterfly Prepona laertes (Lepidoptera : Nymphalidae) ». EDIS 2017, n^o 5 (28 septembre 2017) : 5. http://dx.doi.org/10.32473/edis-in1178-2017.

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Originally published on the Featured Creatures website at http://entnemdept.ufl.edu/creatures/bfly/Prepona_laertes.htm Includes: Introduction - Distribution - Description - Hosts - Selected References

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Ryu, Ji Sun, et Jung Hyun Chae. « The Effect of Home Economics Instruction Applying Flipped and Problem-Based Learning on Middle-School Students’ Metacognition Skill ». Family and Environment Research 60, n^o 4 (30 novembre 2022) : 565–76. http://dx.doi.org/10.6115/fer.2022.038.

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The purpose of this study is to identify the effect of Home Economics Instruction applying Flipped and Problem-Based Learning (FPBL) on Korean middle-school students’ metacognition skill. The study uses a prepost design test of the same group. There were 151 participants (77 male and 74 female) who were middleschool students in the third grade. Two hours of classes on ‘Food Selection and Storage’ were given per week for three weeks – a total of six hours. Analysis using the t-test revealed a statistically significant difference between the pre-test and the post-test, supporting the conclusion that participating in the class improved the metacognition, food selection, and storage behavior scores of the middle-school students. All area scores and overall averages of metacognitive sub-elements such as planning, monitoring, regulation, and evaluation also improved after taking FPBL classes. From the results of this study, Home Economics Instruction applying FPBL is an effective teaching method for improving middle-school students’ metacognition.

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Shrestha, Kamei, Shrestha, Aihara, Bhattarai, Bista, Thapa, Kazama et Shindo. « Socioeconomic Impacts of LCD-Treated Drinking Water Distribution in an Urban Community of the Kathmandu Valley, Nepal ». Water 11, n^o 7 (26 juin 2019) : 1323. http://dx.doi.org/10.3390/w11071323.

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Groundwater available in the Kathmandu Valley is not suitable for drinking due to chemical and microbial contamination. We installed a treatment system, which was made with locally available materials and was low-cost, and supplied drinking water to the intervention site where groundwater contains high amounts of ammonia, iron, and turbidity. This research aims to evaluate the socioeconomic impact of treated water distribution. One hundred households were randomly selected and asked to use treated water for drinking, and another 100 households in the nearby community were taken randomly as a control. We conducted questionnaire surveys with the enrolled households before and five months after starting water distribution to assess the water use patterns and quality perceptions. The socioeconomic impact of the intervention was evaluated by a prepost comparison and by the difference-in-difference method. The intervention significantly enhanced most of the parameters of water quality perception, reduced the in-house water treatment, and improved the perceived water stress and quality of life. For the control site, these parameters generally became worse in the post-survey, which suggests that the survey might have affected people’s mindset regarding water security. The system is an option for sustainable management of drinking water in the water-scarce, hard-hit areas in the developing countries.

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Trabelsi, Khaled, Nicola Bragazzi, Sahar Zlitni, Aimen Khacharem, Omar Boukhris, Kais El-Abed, Achraf Ammar et al. « Observing Ramadan and sleep-wake patterns in athletes : a systematic review, meta-analysis and meta-regression ». British Journal of Sports Medicine 54, n^o 11 (1 juin 2019) : 674–80. http://dx.doi.org/10.1136/bjsports-2018-099898.

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ObjectiveTo evaluate the effect of observing Ramadan on athletes’ sleep patterns.DesignSystematic review and meta-analysis.Data sourcesThe entire content of PubMed/MEDLINE and Web of Science.Eligibility criteria for selecting studiesSingle-group, prepost and cross-over design studies conducted in athletes aged ≥18 years, training at least twice a week and published in English before 12 July 2018 were included. Studies assessing sleep quantity, quality, daytime sleepiness and/or daily naps based on objective or subjective methods were deemed eligible.Study appraisalThe methodological quality was assessed using ‘QualSyst’.ResultsOf 13 selected articles, 7 were of strong quality, 3 were moderate and 3 were weak. 11 studies evaluated total sleep time (TST); this decreased during Ramadan in 4 studies, increased in 1 and remained unchanged in 6. Pooled TST findings indicated a moderate effect size (− 0.97, SE=0.37, 95% CI −1.69 to −0.25, t=−2.64, p=0.01) with significant heterogeneity but no publication bias. Meta-regressions showed no effects of study year, age, sample size, type of sport or competition level, but there were effects of country (with France and Tunisia being the most affected countries and Turkey the least affected, Q=32.14, p<0.0001) and study design (Q=7.74, p=0.02). Four studies measured self-reported sleep quality and it decreased in three studies. One study of sleep architecture reported more frequent waking and more light sleep during Ramadan. Daily nap duration was increased in two studies, but daytime sleepiness remained unchanged in four studies.ConclusionWhen athletes continue to train at least two times/week while observing Ramadan, TST is decreased compared with athletes’ baseline levels.

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Banerjee, Jayanta, Annie Aloysius, Karen Mitchell, Ines Silva, Dimitrios Rallis, Sunit V. Godambe et Aniko Deierl. « Improving infant outcomes through implementation of a family integrated care bundle including a parent supporting mobile application ». Archives of Disease in Childhood - Fetal and Neonatal Edition 105, n^o 2 (21 juin 2019) : 172–77. http://dx.doi.org/10.1136/archdischild-2018-316435.

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ObjectiveThe aim of the Integrated Family Delivered Care (IFDC) programme was to improve infant health outcomes and parent experience through education and competency-based training.DesignIn collaboration with veteran parents’ focus groups, we created an experienced co-designed care bundle including IFDC mobile application, which together with staff training programme comprised the IFDC programme. Infant outcomes were compared with retrospective controls in a prepost intervention analysis.Main outcome measuresThe primary outcome measure was the length of stay (LOS).ResultsBetween April 2017 and May 2018, 89 families were recruited; 37 infants completed their entire care episode in our units with a minimum LOS >14 days. From a gestational age (GA) and birth weight-matched retrospective cohort, 57 control infants were selected. Data were also analysed for subgroup under 30 weeks GA (n=20).Infants in the IFDC group were discharged earlier: median corrected GA (36+0 (IQR 35+0–38+0) vs 37+1 (IQR 36+3–38+4) weeks; p=0.003), with shorter median LOS (41 (32–63) vs 55 (41–73) days; p=0.022). This was also evident in the subgroup <30 weeks GA (61 (39–82) vs 76 (68–84) days; p=0.035). Special care days were significantly lower in the IFDC group (30 (21–41) vs 40 (31–46); p=0.006). The subgroup of infants (<30 weeks) reached full suck feeding earlier (median: 47 (37–76) vs 72 (66–82) days; p=0.006).ConclusionThis is the first reported study from a UK tertiary neonatal unit demonstrating significant benefits of family integrated care programme. The IFDC programme has significantly reduced LOS, resulted in the earlier achievement of full enteral and suck feeds.

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Ilyushkin, M. V., et E. S. Kiselev. « Simulation of the processes of drilling polymer composite blanks using digital twins ». Frontier materials & ; technologies, n^o 2 (2023) : 47–57. http://dx.doi.org/10.18323/2782-4039-2023-2-64-1.

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Polycrystalline composite materials made of carbon fiber reinforced plastics have more and more widespread application in mechanical engineering and become the main material for the production of modern types of high-speed transport. Thus, their share has already reached 35–45 % in the structural design of passenger aircrafts. However, the technology of machining surfaces of parts made of these materials, in particular, holes, is characterized by insufficient knowledge, the absence of regulatory standards for cutting modes and is most often based on the production experience of enterprises. When changing the processing conditions and the material, the pre-production engineering duration causes a significant increase in the cost of manufacturing parts due to the need for experimental selection of the cutting mode rational elements. To exclude the empirical selection of rational elements of the machining equipment cutting mode, the authors considered the possibility of using digital twins for studying the processes of drilling holes in the blanks made of composite materials, including those with the ultrasonic field energy introduction into the new surface shaping zone (to improve the processing quality and productivity). When modeling, the LS-DYNA program was used. The authors prepared the models and processed the results using the LS-PrePost 4.8 program. During the study, an explicit modeling method was used with preliminary validation and calibration of the results of tests of composites. The authors carried out calibration on test operations of tension, three-point bending, and interlaminar shear of the ВКУ-39 polymer composite material based on carbon fibers (carbon fiber reinforced plastic) widely used in domestic engineering. The developed finite element computer models allow simulating drilling procedures without carrying out rather complicated and expensive field tests. As a result of modeling, a simulation file was obtained, which reflects the process of drilling holes in a polymer composite material blank, as close as possible to the real-life situation with chip removal.

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Munaro, Nicola. « Complementizer doubling and subject extraction in Italo-Romance ». Linguistic Variation 18, n^o 2 (31 décembre 2018) : 315–35. http://dx.doi.org/10.1075/lv.00020.mun.

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Abstract In this article I analyze the complementizer doubling construction attested in some early and modern Italo-Romance varieties, where a preposed (clausal or non clausal) constituent associated to the selected clause appears in the embedded left periphery preceded and followed by a subordinating complementizer. While the higher complementizer is uncontroversially interpreted as a lexicalization of the head Force°, the lower complementizer has been taken to lexicalize either the functional head Topic° or the functional head Fin°. Relying on previous formal analyses of subject extraction, I argue that in the varieties in which the lower complementizer lexicalizes Fin°, its presence reflects the lexicalization of the mood features encoded by Fin°, and is ultimately due to the extraction of the thematic subject out of the embedded clause through Spec,FinP, a movement strategy made possible by the presence of an expletive pro in the canonical preverbal subject position.

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Zhao, Lu, Ya-jie Sun et Zhi-qiang Pan. « Topical Steroids and Antibiotics for Adult Blepharokeratoconjunctivitis (BKC) : A Meta-Analysis of Randomized Clinical Trials ». Journal of Ophthalmology 2021 (8 janvier 2021) : 1–9. http://dx.doi.org/10.1155/2021/3467620.

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Purpose. A meta-analysis was conducted to evaluate the efficacy and safety of topical treatments (including steroids and antibiotics) for adults with blepharokeratoconjunctivitis (BKC). Methods. The following databases were searched for relevant randomised controlled trials (RCTs): China National Knowledge Infrastructure (CNKI), Web of Science, MEDLINE, PubMed, Embase, and Cochrane Central Register of Controlled Trials database (CENTRAL). Two reviewers selected studies and analyzed the risk of bias independently. The treatments were loteprednol 0.5%/tobramycin 0.3% (LE/T) and dexamethasone 0.1%/tobramycin 0.3% (DM/T). The efficacy outcome measures were change from baseline (CFB) in composite scores of ocular symptoms and signs; the CFB in the signs composite scores for blepharitis, conjunctivitis, and keratitis at each visit; the total ocular adverse event incidence (AEs); and the incidence of intraocular pressure (IOP) increase after treatment. Prepost mean differences (MDs) were compared for continuous outcome variables, and incidences were analyzed for dichotomous data. The pooled effect sizes were analyzed using 95% confidence intervals (CIs) in a fixed-effect model. Heterogeneity was evaluated using the Q-test and I2 statistic. Results. The CFB to final visit in ocular symptoms and signs of BKC was not statistically different between the two treatments (95% CI, −0.33 to 1.50; MD = 0.58; P = 0.21 ). The CFB in signs composite scores for blepharitis (95% CI, −0.16 to 0.48; MD = 0.16; P = 0.32 ), conjunctivitis (95% CI, −0.55 to 1.76; MD = 0.61; P = 0.30 ), and keratitis (95% CI, 0.00–0.28; MD = 0.14; P = 0.05 ) was also similar with the two treatments. LE/T was a safer intervention than DM/T, with fewer overall adverse events (95% CI, 0.34–0.80; RR = 0.52; P = 0.003 ) and significantly less elevation of intraocular pressure (IOP) (95% CI, 0.32–0.70; RR = 0.47; P = 0.0002 ). Conclusions. DM/T and LE/T are both effective treatments for BKC, but LE/T may be a safer intervention.

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Zhao, Lu, Ya-jie Sun et Zhi-qiang Pan. « Topical Steroids and Antibiotics for Adult Blepharokeratoconjunctivitis (BKC) : A Meta-Analysis of Randomized Clinical Trials ». Journal of Ophthalmology 2021 (8 janvier 2021) : 1–9. http://dx.doi.org/10.1155/2021/3467620.

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Purpose. A meta-analysis was conducted to evaluate the efficacy and safety of topical treatments (including steroids and antibiotics) for adults with blepharokeratoconjunctivitis (BKC). Methods. The following databases were searched for relevant randomised controlled trials (RCTs): China National Knowledge Infrastructure (CNKI), Web of Science, MEDLINE, PubMed, Embase, and Cochrane Central Register of Controlled Trials database (CENTRAL). Two reviewers selected studies and analyzed the risk of bias independently. The treatments were loteprednol 0.5%/tobramycin 0.3% (LE/T) and dexamethasone 0.1%/tobramycin 0.3% (DM/T). The efficacy outcome measures were change from baseline (CFB) in composite scores of ocular symptoms and signs; the CFB in the signs composite scores for blepharitis, conjunctivitis, and keratitis at each visit; the total ocular adverse event incidence (AEs); and the incidence of intraocular pressure (IOP) increase after treatment. Prepost mean differences (MDs) were compared for continuous outcome variables, and incidences were analyzed for dichotomous data. The pooled effect sizes were analyzed using 95% confidence intervals (CIs) in a fixed-effect model. Heterogeneity was evaluated using the Q-test and I2 statistic. Results. The CFB to final visit in ocular symptoms and signs of BKC was not statistically different between the two treatments (95% CI, −0.33 to 1.50; MD = 0.58; P = 0.21 ). The CFB in signs composite scores for blepharitis (95% CI, −0.16 to 0.48; MD = 0.16; P = 0.32 ), conjunctivitis (95% CI, −0.55 to 1.76; MD = 0.61; P = 0.30 ), and keratitis (95% CI, 0.00–0.28; MD = 0.14; P = 0.05 ) was also similar with the two treatments. LE/T was a safer intervention than DM/T, with fewer overall adverse events (95% CI, 0.34–0.80; RR = 0.52; P = 0.003 ) and significantly less elevation of intraocular pressure (IOP) (95% CI, 0.32–0.70; RR = 0.47; P = 0.0002 ). Conclusions. DM/T and LE/T are both effective treatments for BKC, but LE/T may be a safer intervention.

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IVCHENKO, Vadim I., Aliaksei V. SHMIALIOU, Aleksey V. TALALUEV et Aleksey V. OMELIUSIK. « METHODOLOGICAL RECOMMENDATIONS ON TOPOLOGICAL OPTIMIZATION OF POWER STRUCTURES USING NUMERICAL MODELING TOOLS ». Mechanics of Machines, Mechanisms and Materials 4, n^o 61 (décembre 2022) : 68–79. http://dx.doi.org/10.46864/1995-0470-2022-4-61-68-79.

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Methodological recommendations are proposed for the development of the process of topological optimization of load carrying structures adapted for the use of additive technologies. The stage of postprocessing of the polygonal geometry of the part generated as a result of optimization is considered in detail. The validation stage is included in the process of topological optimization by comparing the calculated and experimental data to assess the operability (strength) of the optimized structure. For the option of manufacturing load carrying structures by 3D printing, it is planned to conduct studies of the mechanical properties of the material obtained on a 3D printer, taking into account the printing settings and the orientation of the material layers relative to the applied load during testing. An example of approbation of the proposed methodological recommendations is given on the example of a load carrying hook included in the design of a wheeled transport anti-ram device. The optimization was performed in the SolidThinking Inspire software environment (Altair Engineering, USA). The results of the calculated and experimental determination of the destructive load are presented for the initial and optimized hook design. For the experiment, the hooks were made of ABS plastic using FDM technology. Finite element models of hooks were developed in the ANSYS Workbench software package (ANSYS, USA). Assignment of material properties, boundary conditions and applied load is performed in the LS-PrePost application, calculation in the LS-DYNA solver (ANSYS, USA). The calculated and experimental efficiency estimates were 44.4 and 57.8 %, i.e. their difference is within 13.4 %. The zones and the nature of the destruction identified by calculation and experimentally completely coincide. The results obtained confirm the correctness of the proposed methodological recommendations, the selected modeling approaches and the determination of the properties of the material of the structure manufactured by 3D printing.

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O’Connor, Cath, Rod Lawson, Judith Waterhouse et Gary H. Mills. « Is inspiratory muscle training (IMT) an acceptable treatment option for people with chronic obstructive pulmonary disease (COPD) who have declined pulmonary rehabilitation (PR) and can IMT enhance PR uptake ? A single-group prepost feasibility study in a home-based setting ». BMJ Open 9, n^o 8 (août 2019) : e028507. http://dx.doi.org/10.1136/bmjopen-2018-028507.

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ObjectivesThis feasibility study aimed to assess the acceptability of inspiratory muscle training (IMT) in people with chronic obstructive pulmonary disease (COPD) who declined pulmonary rehabilitation (PR) as a potential treatment option or precursor to PR. Objectives were to assess attitudes to IMT, PR and alternatives to PR; factors influencing adherence with IMT and acceptability of outcome measures, research tools and study protocol.DesignA pragmatic, mixed methods, prepost feasibility study was conducted. Recruitment took place over a 4-month period. Participants were followed up for a period of 6 months.SettingsIMT sessions and assessments were conducted in the domiciliary setting.ParticipantsInclusion criteria: people over the age of 35, stable COPD, Medical Research Council Dyspnoea scale of 3 or above, declined PR. Exclusion criteria: history of spontaneous pneumothorax, incomplete recovery from a traumatic pneumothorax, asthma, known recently perforated eardrum, unstable angina, ventricular dysrhythmias, cerebrovascular event or myocardial infarction within the last 2 months. Participants were selected from a purposive sample. Of the 22 potential participants screened, 11 were recruited and interviewed. Ten participants commenced IMT. Seven participants completed the follow-up assessment.InterventionEight weeks of IMT twice a day, 5 days a week with visits once weekly by a physiotherapist. Unsupervised IMT twice a day three times a week until follow-up at 6 months.OutcomesAcceptability of IMT and the study process was explored via semi-structured interviews. Adherence with IMT was assessed by the Powerbreathe K3 device and participant diaries. Uptake of PR was identified.ResultsIMT was found to be acceptable. Adherence was explored. Four people went on to participate in PR.ConclusionsFeasibility was established. A randomised controlled trial is warranted to establish efficacy and cost-effectiveness of IMT in those who decline PR and IMT as an intervention to promote uptake of PR.Trial registration numberNCT01956565; Post-results.

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Muliani, Muliani, et Lisnawati Lisnawati. « The Effect of Kangaroo Mother Care Method toward Weight Gain and Length of Stay among Low Birth Weight Baby ». International Journal of Public Health Science (IJPHS) 7, n^o 2 (1 juin 2018) : 91. http://dx.doi.org/10.11591/ijphs.v7i2.12632.

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Infant mortality needs to get serious attention. Special efforts are relatively easy and inexpensive in the handling and care is through treatment methods can improve the stability ofKangaroo Mother Care(KMC) for babies and breastfeeding.The effort hopefully will contribute to weight gain which take effect on the duration of treatment. The study design was Quasi Experiment with Prepost one group design. Samples were mothers with a history of low birth weight deliveries, with sample selection technique in consecutive sampling and sample number 36 babies. The samples criteria were infants birth weight between 1,000-2,100 gr, weight of infant when KMC was started between 900-2,100 gr, weight of infants post KMC were 1,300-2,500 gr, babies born with premature or small period of pregnancy. KMC method has the potential to improve the Weight on Low Birth Weight (LBW).Duration of KMC has no effect on weight gain but can accelerate the length of LBW in hospital. The longer do KMC, the shorter duration of hospital LBW in hospital. LBW should be treated KMC to accelerate weight gain and reducing the length of hospitalization.

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Strope, Kerry M., et Mark S. Strefeler. « Effects of Heat Stress on Floral and Vegetative Development in New Guinea Impatiens ». HortScience 31, n^o 4 (août 1996) : 570f—571. http://dx.doi.org/10.21273/hortsci.31.4.570f.

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Fifty-three commercial New Guinea Impatiens cultivars (Impatiens hawkeri Bull.) from six different breeding series were tested for level of heat tolerance. Five floral (flower number, flower length, flower width, floral dry weight, and flower bud number) and five vegetative characteristics (leaf dry weight, stem dry weight, total dry weight, number of nodes, and number of branches) were evaluated with emphasis placed on continued flowering under long term heat stress. Significant differences among cultivars were found in each data category (P ≤ .0001). Flower number varied from 0 to 6, flower length varied from 10 to 51 mm, flower width varied from 10 to 47 mm, floral dry weight varied from 0 to 0.5 g, and flower bud number varied from 0 to 14. Four heat tolerant (Celebration Cherry Red, Celebration Rose, Lasting Impressions Shadow, and Paradise Moorea) and three nonheattolerant (Lasting Impressions Twilight, Danziger Blues, and Pure Beauty Prepona) cultivars were identified using a Weighted Base Selection Index. These cultivars were used as parents in a full diallel crossing block with reciprocals and selfs. One hundred seedlings from each of 49 crosses were evaluated for heat tolerance. General and specific combining abilities of the parents were evaluated as was heritability. It was found that the four heat tolerant cultivars had higher general combining abilities. Heat tolerance has low heritability and is controlled by many genes. Superior genotypes were identified (selection intensity of 0.05) and retained for further evaluation and breeding efforts.

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Özkan, Ramazan, et Mustafa Serdar Genç. « Multi-objective structural optimization of a wind turbine blade using NSGA-II algorithm and FSI ». Aircraft Engineering and Aerospace Technology 93, n^o 6 (13 juillet 2021) : 1029–42. http://dx.doi.org/10.1108/aeat-02-2021-0055.

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Purpose Wind turbines are one of the best candidates to solve the problem of increasing energy demand in the world. The aim of this paper is to apply a multi-objective structural optimization study to a Phase II wind turbine blade produced by the National Renewable Energy Laboratory to obtain a more efficient small-scale wind turbine. Design/methodology/approach To solve this structural optimization problem, a new Non-Dominated Sorting Genetic Algorithm (NSGA-II) was performed. In the optimization study, the objective function was on minimization of mass and cost of the blade, and design parameters were composite material type and spar cap layer number. Design constraints were deformation, strain, stress, natural frequency and failure criteria. ANSYS Composite PrepPost (ACP) module was used to model the composite materials of the blade. Moreover, fluid–structure interaction (FSI) model in ANSYS was used to carry out flow and structural analysis on the blade. Findings As a result, a new original blade was designed using the multi-objective structural optimization study which has been adapted for aerodynamic optimization, the NSGA-II algorithm and FSI. The mass of three selected optimized blades using carbon composite decreased as much as 6.6%, 11.9% and 14.3%, respectively, while their costs increased by 23.1%, 29.9% and 38.3%. This multi-objective structural optimization-based study indicates that the composite configuration of the blade could be altered to reach the desired weight and cost for production. Originality/value ACP module is a novel and advanced composite modeling technique. This study is a novel study to present the NSGA-II algorithm, which has been adapted for aerodynamic optimization, together with the FSI. Unlike other studies, complex composite layup, fiber directions and layer orientations were defined by using the ACP module, and the composite blade analyzed both aerodynamic pressure and structural design using ACP and FSI modules together.

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Strope, Kerry M., et Mark S. Strefeler. « Analysis of Heat Tolerance in New Guinea Impatiens (Impatiens hawkeri) Utilizing Diallel Analysis ». HortScience 32, n^o 3 (juin 1997) : 499B—499. http://dx.doi.org/10.21273/hortsci.32.3.499b.

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Four heat-tolerant (`Celebration Cherry Red', `Celebration Rose', `Lasting Impressions Shadow', and `Paradise Moorea') and three non-heat-tolerant (`Lasting Impressions Twilight', `Danziger Blues', and `Pure Beauty Prepona') cultivars were identified using a Weighted Base Selection Index. These cultivars were used as parents in a full diallel crossing block with reciprocals and selfs. Progeny from five parents (25 crosses) were evaluated for heat tolerance. Four floral (fl ower number, flower diameter, flower bud number, and floral dry weight) and five vegetative characteristics (visual rating, leaf size rating, vegetative dry weight, branch number, and node number) were evaluated with emphasis placed on continued flowering under long-term heat stress. In addition, progeny from all seven parents (49 crosses) were evaluated for inheritance of adaxial leaf color, abaxial leaf color, vein color, and flower color. Significant differences were found in each data category (P < 0.001) with the exception of node number, which was not significant. Flower number varied from 0 to 2, flower diameter varied from 0 to 41 mm, floral dry weight varied from 14 to 105 mg, bud number varied from 0 to 12, branch number varied from 5 to 15, and vegetative dry weight varied from 220 to 607 mg. General and specific combining abilities of the parents were evaluated as was heritability. It was found that the four heat-tolerant cultivars had higher general combining abilities. Heat tolerance has low heritability and is controlled by many genes.

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Alcorn, Sara R., Anna W. LaVigne, Christen R. Elledge, Jacob Fiksel, Chen Hu, Lawrence Kleinberg, Adam Levin et al. « Evaluation of the Clinical Utility of the Bone Metastases Ensemble Trees for Survival Decision Support Platform (BMETS-DSP) : A Case-Based Pilot Assessment ». JCO Clinical Cancer Informatics, n^o 6 (octobre 2022). http://dx.doi.org/10.1200/cci.22.00082.

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PURPOSE The Bone Metastases Ensemble Trees for Survival Decision Support Platform (BMETS-DSP) provides patient-specific survival predictions and evidence-based recommendations to guide multidisciplinary management for symptomatic bone metastases. We assessed the clinical utility of the BMETS-DSP through a pilot prepost design in a simulated clinical environment. METHODS Ten Radiation Oncology physicians reviewed 55 patient cases at two time points: without and then with the use of BMETS-DSP. Assessment included 12-month survival estimate, confidence in and likelihood of sharing estimates with patients, and recommendations for open surgery, systemic therapy, hospice referral, and radiotherapy (RT) regimen. Paired statistics compared pre- versus post-DSP outcomes. Reported statistical significance is P < .05. RESULTS Pre- versus post-DSP, overestimation of true minus estimated survival time was significantly reduced (mean difference –2.1 [standard deviation 4.1] v –1 month [standard deviation 3.5]). Prediction accuracy was significantly improved at cut points of < 3 (72 v 79%), ≤ 6 (64 v 71%), and ≥ 12 months (70 v 81%). Median ratings of confidence in and likelihood of sharing prognosis significantly increased. Significantly greater concordance was seen in matching use of 1-fraction RT with the true survival < 3 months (70 v 76%) and < 10-fraction RT with the true survival < 12 months (55 v 62%) and appropriate use of open surgery (47% v 53%), without significant changes in selection of hospice referral or systemic therapy. CONCLUSION This pilot study demonstrates that BMETS-DSP significantly improved physician survival estimation accuracy, prognostic confidence, likelihood of sharing prognosis, and use of prognosis-appropriate RT regimens in the care of symptomatic bone metastases, supporting future multi-institutional validation of the platform.

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Kasaei, Ali, Nuraini Abdul Aziz, Aidin Delgoshaei, Suraya Mohd Tahir et Alireza Rezanoori. « Optimum gas tank locating in van vehicle – front and side crash analysis consideration for passenger safety ». Engineering Solid Mechanics, 2021, 177–220. http://dx.doi.org/10.5267/j.esm.2020.12.002.

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In this research, crash test results from CNG locating method optimization approach for crashworthiness and testing its safety are presented. The locating process is based on principal energy considerations inspired from the current design process in passenger vehicle design development. The potential of the vehicle concept to absorb kinetic energy can be estimated at the very beginning of the design process by the free crash lengths in the different areas of the vehicle and estimates of average forces required in the specific segment and parts of the car body at particular crash phases. Based on the basic principle of vehicle crash analysis using the finite element method, a passenger VAN finite element model was selected to simulate the front and side rear collision test of the VAN, therefore the LS-DYNA software is adopted to calculate the deformation of the car and the acceleration time history curves during the crashing process; the anti-impact capability of the vehicle is evaluated from this simulation. It is important to determine appropriate force distributions and the corresponding loads paths through the whole structure for all relevant crash load in dedicated crash test cases. The results demonstrate that the improvement of local structure and location for the required CNG tanks in safe locations in vehicle chassis can promote the crashworthiness of the car, but the further improvement needs a major change of the vehicle structure. The outcomes are interpreted by using LS-PREPOST to analyze the energy absorption characteristics during crash for different cases at a velocity of 50km/h the duration of 12ms. The result analysis was necessary to derive distinct deformation phases characteristic and following that, the essential crash elements are compared with and without CNG tanks installation in each crash case. At last, the conclusion determines the proposed tank locating model in the selected passenger VAN is within the safe range of crash analysis standards.

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Hood, Katie Y., Hiba Yusuf, Augusto C. Montezano, Jane E. Findlay, Robson A. Santos, Carlos H. Castro, George S. Baillie, Margaret R. MacLean et Rhian M. Touyz. « Abstract 017 : Ang-(1-7) Influences ET-1 Signaling Through MAS : ETBR Interactions : Implications in Pulmonary Hypertension ». Hypertension 66, suppl_1 (septembre 2015). http://dx.doi.org/10.1161/hyp.66.suppl_1.017.

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ACE2 and Ang 1-7 have been shown to protect against pulmonary hypertension (PH). Mechanisms remain unclear. Considering the important role of ET-1 in PH pathophysiology and endothelial dysfunction, we asked whether Ang 1-7 influences ET-1 signaling in endothelial cells and whether Ang 1-7 treatment influences the ET-1 system in PH. Human microvascular endothelial cells (HMEC) were stimulated with ET-1 in absence/presence of Ang 1-7 and showed that Ang 1-7 increased preproET-1 mRNA (250%), ET-1 release (125%) and ETBR protein (50%), p<0.05. ET-1 increases in e-selectin mRNA (400%), VCAM-1 protein (38%) and TNFα production (30%) were blocked by Ang 1-7, p<0.05. Pro-inflammatory effects were dependent on NO. Ang 1-7 increased NO production (257%) in a Mas and ETBR-dependent manner. Mas and ETBR interaction was observed by immunoprecipitation. To characterise physical interactions between Mas/ETBR, we utilised novel technology, employing a library of peptides scanning the MasR sequence, to define sites of ETBR binding. Substitution and truncation identified regions on MasR that confer specificity for ETBR binding. Peptide disruptors to prevent Mas/ETBR interaction were used for in vitro validation. We previously demonstrated in HMEC that Ang 1-7 stimulates Akt phosphorylation (180%), an effect inhibited by pre-incubation with peptide disruptors, p<0.05. To investigate pathophysiological significance of our findings, we investigated whether Ang 1-7 treatment ameliorates PH and whether this is associated with altered ET-1 status. Hypoxia was used to induce PH in mice: normoxic controls (NC), hypoxic PH (HP), normoxic (NA) and hypoxic PH (HA) treated with Ang 1-7 30μg/kg/day. In HP mice, RVSP (18.7 NC vs. 47.6mmHg HP, p<0.05) RVH (0.19 NC vs. 0.28 HP, p<0.01) and ET-1 levels (0.8 NC vs 2.4pg/ml HP, p<0.05) were increased and blocked by Ang 1-7. Hypercontractility and endothelial dysfunction in pulmonary arteries of HP mice was attenuated by Ang 1-7. These findings indicate that vasoprotective effects of Ang 1-7 may be mediated through MAS:ETBR dimerization. In vivo studies support a relationship between Ang 1-7/MAS and ET-1 systems. In conclusion we have identified a novel link between Ang 1-7 and ET-1 through physical interactions between MAS and ETBR.

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Hood, Katie Y., Hiba Yusuf, Jane E. Findlay, Robson A. Santos, Carlos H. Castro, George S. S. Baillie, Augusto C. Montezano C. Montezano, Margaret R. MacLean et Rhian M. Touyz. « Abstract 316 : Angiotensin 1-7 Regulation Of Endothelin-1 System In Pulmonary Arterial Hypertension ». Hypertension 64, suppl_1 (septembre 2014). http://dx.doi.org/10.1161/hyp.64.suppl_1.316.

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Studies suggest that activation of ACE2-Ang-(1-7)-Mas ameliorates vascular, cardiac and lung damage observed in pulmonary hypertension (PAH); a condition where endothelin-1 (ET-1) is important. Here we assessed whether Ang 1-7 regulates ET-1 system in pulmonary hypertension and putative mechanisms. Hypobaric hypoxia was used to induce hypoxic PAH in mice, which were divided in 4 groups: normoxic controls (NC), hypoxic PAH (HP), normoxic (NA) and hypoxic PAH (HA) treated with Ang 1-7 (hydroxypropyl-βcyclodextrin-Ang(1-7) 30μg/kg/day given by oral gavage for 14 days after established hypoxia-induced PAH. In HP mice, RVSP (18.7 NC vs. 47.6mmHg HP, p<0.001), RVH by Fulton Index (0.198 NC vs. 0.279 HP, p<0.01) and urinary ET-1 levels (0.88 NC vs 2.48pg/ml HP, p<0.05 vs NC) were increased, an effect blocked by Ang1-7 treatment. In NA, Ang 1-7 increased urinary levels of ET-1 (2.24pg/ml, p<0.05 vs NC). No changes were observed on ETBR protein expression between all groups. Human microvascular endothelial cells (HMEC) were also used and stimulated with ET-1 in the absence/presence of Ang 1-7. Ang 1-7 stimulation increased preproET-1 mRNA levels (250%), ET-1 release (125%), and ETBR protein levels (50%), p<0.05 vs vehicle. To examine whether the regulation of ET-1 system by Ang 1-7 is beneficial, HMEC were stimulated with ET-1 in the absence/presence of Ang 1-7. ET-1 increased e-selectin mRNA (400%) and VCAM-1 protein (38%) levels, as well as TNFα production (30%); all effects blocked by Ang 1-7 (p<0.05). Ang 1-7 inhibition of ET-1 pro-inflammatory effects was dependent on NO production, since it was blocked by L-NAME and LY294002 (inhibitors of NO pathway). Interestingly, Ang 1-7 increased NO production (257%) through Mas and ETBR-dependent manner. An interaction between Mas and ETbR was observed in HMEC by immunoprecipitation and peptide array protocols. In conclusion, Ang 1-7 modulates ET-1 system in pulmonary hypertension and HMEC. Our findings indicate that Ang 1-7 negatively modulates proinflammatory signalling in human endothelial cells. The protective effect may involve upregulation/crosstalk of/with ETBR. These data identify the ET-1 system as a novel molecular mechanism involved in the putative protective action of Ang 1-7 in pulmonary hypertension.

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