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Littérature scientifique sur le sujet « Pre-neoplastic lesion »

Auteur : Grafiati

Publié le 9 mars 2023

Mis à jour le 10 mars 2023

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Articles de revues sur le sujet "Pre-neoplastic lesion"

Gobran, Mai A., Soheir El-Ghoneimey, Safaa A. S. Ibrahim et Sabah Mohamedhanafy. « Systemic Lupus Erythematosus as a Risk Factor for Cervical Cancer and its Precursor Conditions : Assessment Using Pap Smear and Histopathology ». Gynecology and Obstetrics Research – Open Journal 8, n^o 1 (30 décembre 2022) : 1–7. http://dx.doi.org/10.17140/goroj-8-155.

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Background Cancer of the cervix is a common cause of malignancy. Its association with systemic lupus erythematosus (SLE) is debatable. Objective Early detection of cervical pre-neoplastic lesion in SLE patients. Method A case control study was performed on 64 SLE group and 64 control group using a colposcopy, pap smear and histopathological examination. Conclusion This study revealed that preneoplastic and neoplastic lesions of the cervix were higher in the SLE group.

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Malik, Ayesha Imtiaz, Farrukh Kamal, Munazza Iqbal, Aasmaa Qureshy et Farah Kalsoom. « Distribution of various histopathological patterns of ovarian lesions in different age groups ». Pakistan Journal of Medical and Health Sciences 16, n^o 7 (30 juillet 2022) : 213–16. http://dx.doi.org/10.53350/pjmhs22167213.

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The spectrum of ovarian pathologies embraces wide age range among females because the risk of developing ovarian lesion starts from birth and follows diverse patterns through-out the life.1,2 The rate of development of complications, recurrence, progression to malignancy, morbidity and mortality, also varies according to the age of presentation of various ovarian pathologies.3,4,5 The prevalence of cystic lesions of ovary is more in reproductive age group as compared to post-menopausal women.6,7 Malignant neoplasms have more been observed in an advanced age group.8,9,10 The current study is aimed to observe the distribution of various histopathological patterns of ovarian lesions in different age groups. This study may be beneficial in stratifying patients, into different risk based groups and prognosis associated groups, depending upon the age of patient at the time of presentation. Methods: Total 150 cases of ovarian lesions were selected by convenient sampling in current descriptive study, carried out at Pathology department of Fatima Jinnah Medical University, Lahore from May, 2019 till June, 2020. Routine H & E stained sections, from specimens of total abdominal hysterectomy with unilateral or bilateral salpingo-oophorectomy, unilateral or bilateral oophorectomy and salpingo-oophorectomy procedures, done either for primary ovarian lesion or other than primary ovarian pathology, in all age groups, were included. Results: A majority of ovarian lesions 123 (82%) were observed in the reproductive age group, mostly being non-neoplastic (89.5%). Out of 19 post-menopausal patients, 12 presented with malignant neoplasms. All patients belonging to pre-pubertal age group had non-neoplastic pathologies. Conclusion: The malignant ovarian tumors are prevalent in post-menopausal patients while reproductive age group predominantly exhibits non-neoplastic and benign ovarian lesions. The pre-pubertal age group commonly present with non-neoplastic ovarian pathologies. Keywords: Histopathological patterns of ovarian lesion, Malignant ovarian tumors, Reproductive age group.

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Bagga, Neha, Poonam Elhence, Meenakshi Rao, Aasma Nalwa, Sudeep Khera, Jyotsna Naresh Bharti, Pratibha Singh et Shashank Shekhar. « A prospective study of cervical lesions diagnosed by liquid based cytology in Western Rajasthan, India population ». International Journal of Research in Medical Sciences 7, n^o 12 (27 novembre 2019) : 4573. http://dx.doi.org/10.18203/2320-6012.ijrms20195521.

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Background: Carcinoma cervix is the second most common malignancy of women in India after breast cancer. The present study was conducted to determine the spectrum of cervical lesions by liquid-based cytology in Western Rajasthan population.Methods: It is a Prospective study on 1087 cervical samples carried over a period of 1 year. Cervical samples were taken and processed by SurePath™ LBC.Results: Of total 1087 cases 959 were negative for intraepithelial lesion or malignancy (88.22%). 88 cases (8.09%) were reported as unsatisfactory. Among the non- neoplastic cases- bacterial vaginosis was reported in 209 cases (21.8%), Candida in 77 cases (8.02%), both Candida and bacterial vaginosis in 12 cases (1.25%), reactive cellular changes in 193 cases (20.12%), and Trichomonas vaginalis in 01 case. Among pre-malignant and malignant lesions, 40 cases (4.17%) the distribution was as follows-atypical squamous cells of undetermined significance 16(1.67%), atypical squamous cell-cannot rule out high grade 08 cases (0.83%), Low grade squamous intraepithelial lesion 04 cases (0.42%), high grade squamous intraepithelial lesion 07 cases (0.73%), Atypical glandular cell favoring neoplastic 01 case (0.15%), and squamous cell carcinoma 04 cases (0.42%). Histopathological co-relation of premalignant and malignant lesions was further studied.Conclusions: Liquid based cytology is an effective screening and diagnostic procedure for cervical abnormalities. Among pre-malignant and malignant lesions, histo-pathological correlation increased with increased grade of severity of lesions. To the best of knowledge, this is the largest study of liquid based cytology in the Western Rajasthan.

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Thakkar, Kunal, Swati Ramteke-Jadhav, Rajeev Kasaliwal, Saba Samad Memon, Virendra Patil, Puja Thadani, Nilesh Lomte et al. « Sellar surprises : a single-centre experience of unusual sellar masses ». Endocrine Connections 9, n^o 2 (février 2020) : 111–21. http://dx.doi.org/10.1530/ec-19-0497.

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Background Most common incidentally detected sellar-suprasellar region (SSR) masses are pituitary adenomas, followed by craniopharyngioma, rathke’s cleft cyst, hypophysitis, and meningioma. Besides these, certain unusual SSR lesions can sometimes present as diagnostic challenges, where diagnosis is often made post-operatively on histopathology, the pre-operative suspicion of which might have influenced the management strategies. Series describing such masses are few. Objective To present clinical, biochemical, and radiological characteristics and management outcomes of rare SSR lesions other than pituitary adenomas, craniopharyngioma, rathke’s cleft cyst, hypophysitis, and meningioma. Design, setting, patients Retrospective case record analysis of patients with uncommon SSR masses (from January 2006 to December 2016). Results Our series consisted of ten patients, five with neoplastic and five with non-neoplastic lesions. Neoplastic masses included granular cell tumor (n = 2), astrocytoma (n = 1), malignant peripheral nerve sheath tumor (MPNST, n = 1), and metastasis from occult papillary carcinoma of thyroid (n = 1), while non-neoplastic masses were aspergillus abscess (n = 1), sterile abscess (n = 1), and tubercular abscess (n = 1), aneurysm of left internal carotid artery (n = 1), and ruptured dermoid cyst (n = 1). All patients (except one) presented with headache and/or visual disturbance. Only one patient had acromegaly while most others had hypopituitarism. We describe detailed MRI characteristics of each of the lesion. Seven patients underwent trans-sphenoidal surgery. Post-operatively, five patients had permanent diabetes insipidus, while two patients died in early post-operative period. Conclusion Our series expand the differential diagnostic considerations of SSR lesions. Most of the rare SSR masses present with symptoms of mass effects and hypopituitarism. Except for some non-neoplastic lesions like sellar abscesses, aneurysms, and dermoid cysts which can have some specific imaging characteristics that can provide clue to pre-operative diagnosis, most of the other neoplastic masses have overlapping radiological features, and pre-operative suspicion remains difficult.

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de Godoy Fernandes, Giovana, Bruna Pedrina, Patrícia de Faria Lainetti, Priscila Emiko Kobayashi, Verônica Mollica Govoni, Chiara Palmieri, Veridiana Maria Brianezi Dignani de Moura, Renée Laufer-Amorim et Carlos Eduardo Fonseca-Alves. « Morphological and Molecular Characterization of Proliferative Inflammatory Atrophy in Canine Prostatic Samples ». Cancers 13, n^o 8 (14 avril 2021) : 1887. http://dx.doi.org/10.3390/cancers13081887.

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Proliferative inflammatory atrophy (PIA) is an atrophic lesion of the prostate gland that occurs in men and dogs and is associated with a chronic inflammatory infiltrate. In this study, we retrospectively reviewed canine prostatic samples from intact dogs, identifying 50 normal prostates, 140 cases of prostatic hyperplasia, 171 cases of PIA, 84 with prostate cancer (PC), 14 with prostatic intraepithelial neoplasia (PIN) and 10 with bacterial prostatitis. PIA samples were then selected and classified according to the human classification. The presence of PIA lesions surrounding neoplastic areas was then evaluated to establish a morphological transition from normal to preneoplastic and neoplastic tissue. In addition, the expression of PTEN, P53, MDM2 and nuclear androgen receptor (AR) were analyzed in 20 normal samples and 20 PIA lesions by immunohistochemistry and qPCR. All PIA lesions showed variable degrees of mononuclear cell infiltration around the glands and simple atrophy was the most common histopathological feature. PIA was identified between normal glands and PC in 51 (61%) out of the 84 PC samples. PIA lesions were diffusely positive for molecular weight cytokeratin (HMWC). Decreased PTEN and AR gene and protein expression was found in PIA compared to normal samples. Overall, our results strongly suggest that PIA is a frequent lesion associated with PC. Additionally, this finding corroborates the hypothesis that in dogs, as is the case in humans, PIA is a pre neoplastic lesion that has the potential to progress into PC, indicating an alternative mechanism of prostate cancer development in dogs.

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Akhtar, Zahid Mahmood, Madiha Arshad et Rabia Altaf. « Frequency of Thyroid Lesions at Pathology Department of King Edward Medical University Lahore ». Pakistan Journal of Medical and Health Sciences 16, n^o 3 (26 mars 2022) : 146–48. http://dx.doi.org/10.53350/pjmhs22163146.

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Background: Thyroid gland is notorious for carrying commonest endocrine pathologies and also for commonest endocrine malignancy. It is the 5th most common cancer in human beings. This makes to carry out current study to get insight of frequency of thyroid lesions at tertiary care level. Methods: This was a descriptive cross-sectional study. The study was done at the Department of Pathology, King Edward Medical University Lahore with the collaboration of four surgical units of Mayo Hospital Lahore from 2010 to 2019. Total 1601 cases were included. Information about age, sex and diagnosis was entered in the pre designed proforma. SPSS version 22 was used for data analysis. Descriptive analysis was done and the results were presented as frequencies, percentages and ratios. The results were then studied against local and international data. Results: This study revealed non neoplastic and neoplastic lesions as 1323 (82.63%) and 278 (17.37%) respectively. Bulk of the lesions 61.6% were between the age bracket of 20-39 years. Mean±SD for age was 34.22±11.42 years. Female to male ratio(F:M) was in favour of females as 9.81:1. Among the non neoplastic lesions, MNG 1151(87%) was a dominant lesion followed by TH 82(6%). LT 29(2.19%) and HT 26(1.96%) were other important lesions. F:M ratio was 10.80:1. Neoplastic lesions were divided into benign 178(64%) and malignant tumors 100(36%). FA was the leading benign neoplasm 164(59%). Rest of the benign tumors shared a minor fraction except HCA 12(4.31%). Among the malignant category, Papillary carcinoma 69(24.82%) dominated over MC 12(4.31%). FC 7(2.51%) and AC 6(2.15%) were other significant findings. F:M ratio in malignancy was 3.16:1 which was significantly lower than 13.83:1 in benign tumors. Conclusion: MNG is the dominant lesion among the non neoplastic lesions while in the neoplastic category FA was leading as benign neoplasm. Papillary carcinoma turned out to be the commonest malignant tumor. Major share of all the lesions were seen between 20-39 years. Keywords: MNG, Papillary carcinoma, Follicular adenoma, neoplastic lesions

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Machiwal, Kishan, Bhawika Menghani, Neena Kasliwal et M. P. Sharma. « Histopathological spectrum of lesions in gastrointestinal endoscopic biopsies in Jawahar Lal Nehru Medical College and associated group of Hospitals, Ajmer, Rajasthan ». International Journal of Research in Medical Sciences 10, n^o 12 (25 novembre 2022) : 2831. http://dx.doi.org/10.18203/2320-6012.ijrms20223084.

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Background: The gastrointestinal tract which extends from the esophagus to anus is a common site for numerous pathological processes from non-neoplastic, pre-neoplastic, to neoplastic. Gastrointestinal tumors including both benign and malignant tumors are the major cause of morbidity and mortality worldwide. Endoscopy in combination with endoscopic biopsy plays an important role in detecting early cancers and/or high-grade dysplasia and in the diagnosis of upper and lower gastrointestinal tract neoplasms and therefore aids in their early management.Methods: This study was done for 1 year from July 2018 to June 2019 (retrospectively) and over a period of 1 year from July 2019 to June 2020 (prospectively). All endoscopic biopsies samples were received in the department of pathology at J. L. N. Medical College and Associated Group of Hospital, Ajmer, Rajasthan.Results: The mean age of patients were 51.91±18.86 years and highest incidence of gastrointestinal (GI) disease was seen between the age group of 51-60 years. The male: female (M: F) ratio was 1.46: 1. Non neoplastic lesions are more common than neoplastic lesions. Inflammatory lesion was the most commonly observed lesion followed by malignant lesions. The sensitivity of endoscopy is 96.25%, specificity is 68.67%, the positive predictive value is 74.76% and the negative predictive value is 95%. Accuracy for diagnosis by endoscopy is 82.21%.Conclusions: Endoscopic biopsy correlation reflects important advances in understanding the pathophysiology of disease and prognosis and survival rates after staging in the case of carcinomas. It provides diagnostic information and aids in improving patient management.

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Zhang, Jianjun, Dan Su, Junya Fujimoto, Lisa Ying, Chi-Wan Chow, Wenyong Sun, Jianhua Zhang et al. « Multiregion whole exome seuquencing of pre- and early neoplastic lung lesions. » Journal of Clinical Oncology 35, n^o 15_suppl (20 mai 2017) : e20042-e20042. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.e20042.

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e20042 Background: The widespread use of CT for lung cancer screening and other reasons has resulted in a dramatic increase in the number of indeterminate ground glass opacities (GGOs). While many of GGOs can be resected with minimal morbidity, the cost has been called into question. Furthermore, multifocality is a relatively common, which makes decisions on extent of surgical resection and potential benefit less clear. Chemoprevention is a theoretically appealing approach to reduce lung cancer incidence and mortality. However, randomized trials have been disappointing to date. This may be due to the constellation of many factors including lack of reliable biomarkers to identify high-risk patients, lack of appropriate molecular targets and appropriate drugs because of our rudimentary knowledge on early carcinogenesis of lung cancers. It has been postulated that atypical adenomatous hyperplasia (AAH) represents preneoplastic lesion that can progress to adenocarcinoma in situ (AIS), minimally invasive adenocarcinoma (MIA) and further to frankly invasive adenocarcinoma (ADC). However, the biology of these lesions is poorly understood and the definition and management of these lesions remain controversial. Methods: Study on early carcinogenesis is hampered by the small size of lesions and challenge of obtaining longitudinal samples at different stages of disease progression. Multiregion sequencing can depict genomic events relative to molecular time with early events ubiquitously present in all regions and late mutations confined to spatially separated regions of lesions. Using this approach, our recent work has reported that 20/21 canonical cancer gene mutations were early genetic events. Results: With intent to delineate the pivotal molecular events driving early carcinogenesis of lung cancer, we have collected 154 resected GGOs with including AAH (N = 40), AIS (N = 39), MIA (N = 55) and ADC (N = 20) based on the IASLC/ATS/ERS classification from 89 patients including 38 patients presenting with multifocal GGOs and 18 patients carry more than one type of pathology. Two to five spatially separated regions from each of the 154 lesions are subjected to whole exome sequencing. Conclusions: The data will be ready to present at the meeting.

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Chaudhary, Aishwarya, et Aarti B. Bhattacharya. « The Study on the Clinico-pathological Spectrum of Non-neoplastic and Neoplastic Lesions in Cholecystectomy Specimens at a Tertiary Care Centre ». Annals of Pathology and Laboratory Medicine 9, n^o 2 (5 mars 2022) : A44–49. http://dx.doi.org/10.21276/apalm.3118.

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Background: Most commonly used surgical procedure for gall-bladder pathology is cholecystectomy. Gall-bladder diseases incidence has increased over the past decade and are cause for a number of histopathological changes like pre-neoplastic conditions and ultimately culminating into the neoplasia. Histopathologic examination of the specimen serves as the absolute diagnosis of the non-neoplastic and neoplastic lesions as pre-operative imaging techniques fail to identify the lesions Aim: To analyse the clinico-pathological spectrum of various non- neoplastic and neoplastic lesions occurring in cholecystectomy specimens with and without gall bladder calculus. Materials & Method: An observational, cross-sectional study was conducted between 2019 to 2020 at a tertiary care centre in Safedabad, Barabanki, UP. A total of 135 cholecystectomy specimens were evaluated for histopathological examination. After histopathological reporting all cases were clinicopatholically related. Data was analysed using SPSS software, the demographic data were presented as frequency, percentage; continuous variables with mean and standard deviation. Results: 74.8% were females (n=101) and 25.2% were males (n=34) with mean age of 42.96 years. Gall-bladder stone was present in 85.2% of patients (n=115) and absent in 14.8% patients (n=20). Neoplastic lesion in 7 of the patients, 5 patients with adenocarcinoma, 1 patient with adenosquamous carcinoma and 1 patient with papillary adenocarcinoma. Gall-bladder carcinoma were diagnosed in our study; the poorly differentiated GBC revealed high Ki67 Score. Conclusion: Gall-bladder diseases can have a varied presentation both clinically and histopathologically. Hence, a complete and meticulous macroscopic and microscopic examination of all cholecystectomy specimens should be mandatory for better patient care.

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Kaplanoğlu, Veysel, Deniz Sözmen Ciliz, Hatice Kaplanoğlu et Eda Elverici. « Aneurysmal Bone Cyst of the Calcaneus ». Journal of Clinical Imaging Science 4 (31 octobre 2014) : 60. http://dx.doi.org/10.4103/2156-7514.143732.

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Aneurysmal bone cysts (ABCs) are benign, non-neoplastic, expansile, vascular, locally destructive lesions. The lesion may arise de novo (65%) or secondarily (35%) in pre-existing benign or malignant lesions (giant cell tumor, osteoblastoma, chondroblastoma, angioma, and others). The calcaneus is a rare localization for ABC, comprising only 1.6% of the cases. In this paper, we present a case of a female patient with a 3-month history of heel pain that got worse and was accompanied by swelling and difficulty in walking. The magnetic resonance images of the postero-lateral calcaneus showed a contrast-enhanced cystic lesion located in the medullary cavity; exophytic portion of the tumor extended into the soft tissue causing distinctive cortical thinning. Heterogeneous hyperintense septae formations and blood level components were also detected. After correlation with pathology results, the lesion was diagnosed as an ABC. Since an ABC of the calcaneus is a rarely seen phenomenon, we present the radiologic findings in this case and a review of the literature.

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Thèses sur le sujet "Pre-neoplastic lesion"

FRANCESCHINI, FABIO GIULIO. « Correlazioni esistenti tra parodontologia e medicina orale. Lesioni delle mucose orali versus malattia parodontale. Aspetti diagnostici e terapeutici ». Doctoral thesis, Università degli Studi di Milano-Bicocca, 2011. http://hdl.handle.net/10281/19339.

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Our study describes the relationship between periodontal disease and oral mucosal lesions. At first we analysed classification criteria of oral lesions in order to provide a point of reference for an adequate description. In a second time we started to describe periodontal disease, that is a common pathology all over the world with high costs for therapy and rehabilitations. Also classification of periodontal disease is important, because there are different types of disease, with various clinical aspects. We used the AAP (American Academy of Periodontology) classification of 1999, that reports: gingivitis, chronic periodontitis, aggressive periodontitis, periodontitis related to systemic diseases, necrotizing periodontitis, periodontal abscess, periodontitis associated to endodontic lesions, acquired and developed deformities and conditions. In the second part we described oral mucosal lesions, starting with infective diseases on the basis of etiologic agents: bacterial, viral (with viral neoplasms), fungal, parasitic and syphilitic lesions. In the third part we described autoimmune lesions, in particular the erythema multiform. In the fourth part we analysed the neoplastic and pre-neoplastic diseases, in particular squamous cell carcinoma and leukoplakia. Fifth section is dedicated to “border lesions”, because they are studied both in periodontology and oral medicine. These diseases are the desquamative gingivitis, lichen planus, pemphigoid, pemphigus, linear IgA disease, chronic ulcerative stomatitis and epulid.

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Nicholson, J. « Predicting malignancy in pre-neoplastic lesions detected during screening for pancreatic cancer ». Thesis, University of Liverpool, 2017. http://livrepository.liverpool.ac.uk/3008012/.

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Background: Screening is offered to individuals who have an identified increased risk of pancreatic cancer. Such risks may be increased because of a family history or a known genetic mutation which has been shown to confer increased risk. Amongst those being screened intraductal papillary mucinous neoplasm (IPMN) of the pancreas are increasingly common entities being detected incidentally; their risk of malignancy can be as high as 85%. Consensus guidelines exist for the management of these lesions – the morbidity associated with pancreas resection is as high as 50%. We set out to identify a marker which could be used to identify those IPMN which should be resected and those which may be safely observed. Methods: Individuals were identified from the European Registry of Hereditary Pancreatitis and Familial Pancreatic Cancer (EUROPAC) or patients identified in Liverpool or Hedielberg with cystic lesions and/or pancreatic cancer. Cancer screening was performed by imaging and with molecular analysis (including mutation analysis of TP53) of pancreatic juice obtained by endoscopic retrograde cholangiopancreatography (ERCP). Matched tissue sections and frozen sections of pancreatic tissue from 73 patients who underwent resection for IPMN were assessed histologically and for mutations in TP53 status using a novel limiting dilution Next Generation Sequencing technique. Results were assessed relative to clinical outcomes. Results: Amongst those 29 individuals who were screened with ERCP, 11 had IPMN, 7 IPMN with cancer (IPMC) and 3 pancreatic ductal adenocarcinoma (PDAC). The remaining cases were benign neoplastic or inflammatory conditions. Kaplan-Meier survival analysis at 5 years found that the presence of p53 mutation in the tissue was a better prognostic marker of survival than the histological diagnosis alone (p=0.0152 vs. p=0.0819). Sensitivity and specificity of p53 mutation as a predictor of survival was calculated as 0.89 and 0.95 respectively. There was 100% correlation between the p53 mutational status of the resected tissue and the pancreatic juice obtained at ERCP. When ERCP was assessed as a method for screening, however, there was found to be an unacceptably high incidence of post-ERCP pancreatitis (PEP) 7 cases of PEP in 16 ERCPs (44%). This rate was shown to be significantly reduced to 15% (6/40) with the use of pancreatic stent and diclofenac, but the overall prevalence of PEP was 23.2% over 14 years. There were no cases of PEP amongst those individuals being screened because of hereditary pancreatitis. Of 27 IPMN cases with frozen tissue 23 individuals had TP53 mutations. Seven cases died of pancreatic cancer after resection. Kaplan-Meier survival analysis revealed that one mutation p.L264R predicted survival regardless of histology (p= < 0.0001). The mutation was present in 6 of the 7 cases who died and in none of those who survived to 5 years. Mutation specific PCR was used to validate results showing that p.L264R discriminated between survivors and IPMN cases who died of cancer (AUC = 0.79). Conclusions: IPMN continues to cause concern and uncertainty among those individuals being screened for cancer who are largely well and asymptomatic. The p.L264R mutation could be used to differentiate those IPMN which result in poor survival to facilitate potentially curative surgery. The mutation may be present in pancreatic juice which can be collected endoscopically as a screening tool. The use of prophylactic measures to reduce PEP may be considered sufficient to bring the risk of complications to an acceptable level when compared to the relative certainty of prognosis afforded by a positive test for p.L264R.

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Saffi, Junior Mario Cezar. « Potencial dos fatores de risco associados aos marcadores biomoleculares RNAm IDO E RNAm CDKN2A/p16 na predição das lesões precursoras do câncer de colo uterino ». Universidade Nove de Julho, 2015. http://bibliotecadigital.uninove.br/handle/tede/1300.

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The cervical cancer is the first cancer of the female genital tract in Brazil and HPV is essential factor for carcinogenesis. The Brazilian program tracking proposes conventional cervical cytology as the primary method to detect cervical cancer, despite its low sensitivity. Risk factors associated with the spread of HPV are despised and not rely on a biomolecular tool that can increase the program offered by the Ministry of Health. The aim of this study was to determine whether the risk factors for cervical cancer may contribute to the conventional cervical cytology to increase diagnostic sensitivity and assess whether the mRNA indoleamine 2,3 dioxygenase (IDO) and mRNA CDKN2A / p16 may increase the diagnostic yield of this neoplasm. The logistic regression analysis was based on clinical variables (risk factors), cytological and biomolecular to seek an association with pathological results. The proportion of explained variance (PVE) for each variable studied was calculated by the formula omega, whereas the sensitivity, specificity, positive predictive value and negative predictive value were calculated by the formulas of Galen and Gambino. We conclude that oral contraceptive showed greater predictive power of high-grade lesions compared to other risk factors, and that both the IDO mRNA as CDKN2A mRNA / p16 may help screening of cervical cancer, either when used alone, or in conjunction with conventional cervical cytology, increasing their sensitivity and maintaining a considerable specificity.
O câncer de colo uterino apresenta-se como a principal neoplasia do trato genital feminino no Brasil, sendo o HPV fator essencial para a carcinogênese. O programa brasileiro de rastreamento propõe a citologia oncológica cervical convencional como principal método para detectar o câncer do colo uterino, apesar da sua baixa sensibilidade. Os fatores de risco associados ao contágio do HPV são desprezados e não contamos com uma ferramenta biomolecular que possa incrementar o programa oferecido pelo Ministério da Saúde. O objetivo desse trabalho foi verificar se os fatores de risco para o câncer de colo uterino podem contribuir com a citologia oncológica cervical convencional para aumentar a sensibilidade diagnóstica e avaliar se o RNAm Indoleamine 2,3 dioxigenase (IDO) e o RNAm CDKN2A/p16 podem incrementar a capacidade diagnóstica dessa neoplasia. A análise de regressão logística foi baseada nas variáveis clínicas (fatores de risco), citológicas e biomoleculares a fim de buscar uma associação com o resultado anatomopatológico. A proporção de variação explicada (PVE) por cada uma das variáveis estudada foi calculada pela fórmula ômega, enquanto que a sensibilidade, especificidade, valor preditivo positivo e o valor preditivo negativo foram calculados pelas fórmulas de Galen e Gambino. Concluímos que o uso do contraceptivo oral mostrou um maior poder de predição de lesões de alto grau em relação aos demais fatores de risco, e que tanto a RNAm IDO quanto o RNAm CDKN2A/p16 poderem auxiliar no rastreamento do câncer de colo uterino, seja quando usados de forma isolada, seja conjuntamente com a citologia cervical convencional, elevando sua sensibilidade e mantendo uma considerável especificidade.

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VALENTE, ROBERTO. « Effects of aspirin, ace-inhibitors/sartans and statins on neoplastic and pre- neoplastic lesions of the pancreas ». Doctoral thesis, 2019. http://hdl.handle.net/11573/1210183.

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Aspirin, ace inhibitors/sartans and statins are largely used in primary or secondary cardiovascular prophylaxis. Such drugs have been suggested to play also a role in inhibiting cancer initiation and progression in several clinical and preclinical humoral models. So far, they role in the initiation and progression of pancreatic neoplastic and preneoplastic lesions has been poorly investigated. The aim of the current thesis is to evaluate the effect of such drugs on the progression of pancreatic BD-IPMNs, on the recurrence of cancer after surgery for IPMNs, as well as to evaluate a possible influence in modulating the incidence of pancreas cancer and neuroendocrine tumors.

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Kessler, Jessica Dawn. « Investigating the Fate of Pre-neoplastic Cells in a Mouse Model of Medulloblastoma ». Diss., 2009. http://hdl.handle.net/10161/1186.

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Studying the early stages of cancer can provide important insight into the molecular basis of the disease. In many human cancers, such as prostate, pancreatic, and colon cancer, a pre-neoplastic, or intermediate, stage of the disease has been identified. The pre-neoplastic stage is presumed to be a transition during which normal cells undergo malignant transformation. However, the link between the pre-neoplastic cells and end-stage disease has never been formally established. To investigate the fate of such cells, the patched (ptc) mutant mouse, a model for the brain tumor medulloblastoma was used. Pre-neoplastic cells (PNCs) are found in most ptc mutants during early adulthood, but only 15% of these animals develop tumors. Although PNCs are found in mice that develop tumors, the ability of PNCs to give rise to tumors has never been demonstrated directly, and the fate of cells that do not form tumors remains unknown. Genetic fate mapping and orthotopic transplantation provided definitive evidence that PNCs give rise to tumors and showed that the predominant fate of PNCs that do not form tumors is differentiation. Moreover, N-myc, a gene commonly amplified in medulloblastoma, can dramatically alter the fate of PNCs, preventing differentiation and driving progression to tumors. Importantly, N-myc allows PNCs to grow independently of hedgehog signaling, making the resulting tumors resistant to hedgehog antagonists. These studies provide the first direct evidence that PNCs can give rise to tumors, and demonstrate that identification of genetic changes that promote tumor progression is critical for designing effective therapies for cancer.

Dissertation

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Paula, Arnaud Fabian da Cruz. « Characterization of different breast cancer stem cell phenotypes in proliferative, pre-malignant and neoplastic lesions of the breast : associations with breast cancer behavior and progression ». Doctoral thesis, 2016. https://hdl.handle.net/10216/86451.

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Chapitres de livres sur le sujet "Pre-neoplastic lesion"

Russo, Jose. « The So Called Pre-Neoplastic Lesions and Carcinoma In Situ ». Dans The Pathobiology of Breast Cancer, 21–46. Cham : Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-40815-6_2.

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Terzuoli, L., B. Frosi, B. Porcelli, F. Carlucci, C. Minacci, R. Vernillo, L. Baldi, A. Tabucchi et E. Marinello. « Immunohistochemical Analysis of P185 and ASL Activity in Pre-Neoplastic Lesions and Intestinal Mucosa of Human Subjects ». Dans Advances in Experimental Medicine and Biology, 805–9. Boston, MA : Springer US, 1998. http://dx.doi.org/10.1007/978-1-4615-5381-6_155.

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Actes de conférences sur le sujet "Pre-neoplastic lesion"

Cui, Changxu, Reika Takamatsu, Hiroshi Doguchi, Akiko Matsuzaki, Masanao Saio et Naoki Yoshimi. « Abstract 4416 : The pre-neoplastic lesion, mucin-depleted foci, reveals asde novohigh-grade dysplasia in rat colon carcinogenesis ». Dans Proceedings : AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012 ; Chicago, IL. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/1538-7445.am2012-4416.

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Amorim, Renée Laufer, Carlos Eduardo Fonseca-Alves, Marcela M. p. Rodrigues et Silvia Regina Rogatto. « Abstract 303 : A tissue microarray-based study of the basal cell in canine prostatic hyperplastic, pre-neoplastic and neoplastic lesions. » Dans Proceedings : AACR 104th Annual Meeting 2013 ; Apr 6-10, 2013 ; Washington, DC. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.am2013-303.

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Lowe, Frazer, Xufei Zhang, Hao Wang, Jinchi Zu, Weike Shen et Li Zhong. « Abstract 2360 : A novel auto-antibody test for the detection of pre-neoplastic lung lesions. » Dans Proceedings : AACR 104th Annual Meeting 2013 ; Apr 6-10, 2013 ; Washington, DC. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.am2013-2360.

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Axelrod, D., J. Smith, B. Singh, W. Ruan, S. Lubitz et D. Kleinberg. « Breast Cancer Chemoprevention in Pre-Neoplastic Lesions with a Somatostatin Analog in Nine Women : A Proof of Principle Trial. » Dans Abstracts : Thirty-Second Annual CTRC‐AACR San Antonio Breast Cancer Symposium‐‐ Dec 10‐13, 2009 ; San Antonio, TX. American Association for Cancer Research, 2009. http://dx.doi.org/10.1158/0008-5472.sabcs-09-1044.

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Jamal, S., H. Seddik et A. Benkirane. « PROSPECTIVE STUDY SHOWING THE CORRELATION BETWEEN THE SEVERITY OF HP GASTRITIS AND PRE-NEOPLASTIC LESIONS IN A MOROCCAN POPULATION ». Dans ESGE Days. © Georg Thieme Verlag KG, 2020. http://dx.doi.org/10.1055/s-0040-1704603.

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Ricci, Caterina, Vanda Salutari, Maria Vittoria Carbone, Viola Ghizzoni, Maria Teresa Perri, Elena Giudice, Maria Teresa Evangelista, Rosa De Vincenzo, Giovanni Scambia et Domenica Lorusso. « TP042/#1526 A single arm phase II study on pembrolizumab in pre-neoplastic high grade HPV-related vulvar and cervical lesions ». Dans IGCS 2022 Annual Meeting Abstracts. BMJ Publishing Group Ltd, 2022. http://dx.doi.org/10.1136/ijgc-2022-igcs.551.

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Sharma, Akanksha, Saritha Shamsunder, Geetika Khanna, Neeti Khunger et Vijay Zutshi. « Chronic vulval problems : A gynaecologist’s perspective ». Dans 16th Annual International Conference RGCON. Thieme Medical and Scientific Publishers Private Ltd., 2016. http://dx.doi.org/10.1055/s-0039-1685355.

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Introduction: Chronic vulval symptoms are common complaints in women seeking health care and can significantly interfere with a woman’s sexual function and sense of well being. Many practitioners feel diagnostically challenged, particularly by chronic or recurrent forms of vulval disease. The aim of this study was to assess the role of various diagnostic modalities in evaluation of chronic vulval symptoms. Methods: Between August 2012 and February 2014, 100 women presenting with chronic vulval symptoms (i.e. ≥ 3 months duration) were evaluated. All of them had a thorough clinical history taken including use of vulval washes and creams, a general and gynaecological examination. Patients having chronic vaginal discharge in addition had urethral, vaginal and cervical smear and culture. All women had a careful examination of the vulva with and without magnification. Vulval scrape cytology was taken after moistening the vulva with normal saline and stained by Pap stain. Colposcopy of the vulva was then carried out after applying 5% acetic acid and 1% toluidine blue dye. Vulval biopsy was taken from suspicious areas on colposcopy and further management was based on histopathology report. Results: The mean age of women in our study was 43.57 years (range 22-80 years.), 70% women were pre-menopausal and 30% were post-menopausal. The mean duration of symptoms was 1.625 years (range 6 months - 15 years) and atypical vulval hygiene practices (excessive washing with soaps) was used in 77% of women. The commonest presenting complaint was pruritus in 92% of women; visible lesions on vulva were seen in 20%, pain in 6% and burning sensation in vulva in 5% of women. The histopathology was abnormal in 77 patients; the most common histopathological finding was non-neoplastic epithelial disorders in 64 women {Squamous cell hyperplasia (n=52), Lichen Sclerosus et atrophicus (n=6), other dermatoses including lichen Planus (n=6)}. Vulvar Intra-epithelial Neoplasia (VIN) was seen in 6 patients, 5 were squamous type VIN and 1 was non-squamous type (Paget’s disease). Squamous cell carcinoma was seen in 3 patients; malignant melanoma, benign appendiceal tumor, angiofibroma and neurofibroma in 1 patient. Examination without magnification had sensitivity of 25.97% and with magnification was 29.87% and specificity was 100% for both of them. Cytology had sensitivity and specificity of 75.32% and 86.95% respectively and sensitivity and specificity of colposcopy was 77.92% and 17.39% respectively. Conclusion: Clinical examination with and without magnification had low sensitivity but were highly specific in diagnosing vulvar lesions. A normal vulval smear and colposcopy have a high negative predictive value and are very reassuring. Colposcopy and biopsy is the gold standard for diagnosis, however clinical examination with naked eyes and magnifying glass are invaluable and can diagnose most of the neoplastic lesions.

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Lucena-Cacace, Antonio, Manuel P. Jiménez-García, Irene Ferrer, Blanca Felipe Abrio, Eva M. Verdugo-Sivianes, Daniel Otero Albiol, Marco Perez et al. « Abstract 655 : Determination of the pro-oncogenic role of PIM1/PIM2 kinases in male reproductive system pre-neoplastic lesions by using conditional transgenic murine models ». Dans Proceedings : AACR 107th Annual Meeting 2016 ; April 16-20, 2016 ; New Orleans, LA. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.am2016-655.

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