Articles de revues : « Phytocomplex »

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Landina, L. N. « Standardization of Dry Extract of Pumpkin Pulp Juice, Which Has a Hypolipidemic Effect on the Content of Β-Carotene ». Medicina 9, n^o 1 (2021) : 79–92. http://dx.doi.org/10.29234/2308-9113-2021-9-1-79-92.

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The objective is to standardize the content of β-carotene – one of the principal active substances with sufficient hypolipidemic activity in the resultant original product. Search for natural biologically active substances having a hypolipidemic effect is one of the topical questions in modern pharmacy. Most of the research is carried out by means of isolating individual substances from the plant object. We propose to study a native phytocomplex obtained from pumpkin pulp – a dry extract of pumpkin pulp juice. The following materials and methods were used: laboratory-obtained dry extract of pumpkin pulp juice and methods used to determine the qualitative and quantitative content of β-carotene in an individual substance. It was possible to adapt the methods applied to the analysis of an individual substance in relation to the resulting phytocomplex containing both lipophilic and hydrophilic fractions. The rapid method of quantitative determination of β-carotene described in the scientific literature was corrected. An effective alternative method for spectrophotometric determination of β-carotene in the phytocomplex has been developed. Phytocomplexes standardized for the main active substances can be used to obtain effective drugs and biologically active additives with minimal side effects. In addition, the expansion of the search for alternative natural objects containing complexes haaving a hypolipidemic effect is currently relevant. Based on the literature data, in the future it is planned to conduct a pharmacological study to establish the anti-inflammatory effect of the resulting complex on the state of the vascular wall.

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Babaskina, Liudmila Ivanovna, Tatiana Mikhailovna Litvinova, Dmitrii Vladimirovich Babaskin et Olga Valerevna Krylova. « Control of the Transdermal Delivery Process of Active Substances of the Phytocomplex during Phonophoresis in Model Experiments ». Open Access Macedonian Journal of Medical Sciences 7, n^o 13 (4 août 2019) : 2079–83. http://dx.doi.org/10.3889/oamjms.2019.607.

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BACKGROUND: The scientific substantiation for the selection of therapeutically significant dosage of phytocomplex in the dosage form for phonophoresis, control over the delivery of active substances into the body, and what affects this process require the study of the kinetics of phytocomplex flavonoids delivery during phonophoresis. AIM: The aim was to study the possibilities of controlling the process of transdermal delivery of phytocomplex active substances (flavonoids) during phonophoresis in vitro model experiments. METHODS: Working compositions with different concentrations of phytocomplex for phonophoresis were used. The content of flavonoids in the compositions was determined using the spectrophotometric method and was calculated equivalent to quercetin, the flavonoid prevailing in the phytocomplex. The study of the kinetics of flavonoids delivery from working compositions was carried out using Franz diffusion cells and Carbosyl-P membranes. The authors determined the main parameters of the process and established the dependence of the delivery rate of flavonoids on their initial concentration in the working composition. The authors studied the effect of dimethyl sulfoxide and the base-forming substances of the working composition on the kinetics of phytocomplex flavonoid delivery during phonophoresis. RESULTS: The authors recorded an increase in the rate of delivery of the active substances from working compositions containing dimethyl sulfoxide into the model medium by almost 1.5-2 times during the first ten minutes of the experiment (approximate duration of the phonophoresis procedure). The authors proposed technological techniques for improvement of the phonophoresis method for the phytocomplex. The possibilities of control over the process of transdermal delivery of the phytocomplex active ingredients during phonophoresis in vitro model experiments were shown. CONCLUSION: The obtained results provide information for further pharmacological studies of the nature and mechanism of the effect of phytocomplex flavonoids during phonophoresis in the rehabilitation of patients with osteoarthrosis.

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Babaskina, Liudmila Ivanovna, Tatiana Mikhailovna Litvinova, Dmitrii Vladimirovich Babaskin, Mikhail Valentinovich Kiselevsky, Olga Vladimirovna Savinova et Elizaveta Aleksandrovna Winter. « Influence of Flavonoids on the Cytotoxic Activity of Mononuclear Blood Cells in Model Tests ». Open Access Macedonian Journal of Medical Sciences 7, n^o 12 (2 juillet 2019) : 1900–1904. http://dx.doi.org/10.3889/oamjms.2019.331.

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BACKGROUND: The spread of phytocomplex application and justification of its selective effects on tumour cells (mainly due to the presence of flavonoids) require research of its cytotoxic and immunomodulatory activity. AIM: The goal was to study the direct cytotoxic effect of the phytocomplex and its modulating effect on the cytotoxic activity of the donor's mononuclear blood cells in in vitro experiments. METHODS: The phytocomplex was a dry extract from marsh cinquefoil, creeping alfalfa and common hop; its main active ingredients were flavonoids. Transplantable monolayer cultures of lung adenocarcinoma, colorectal cancer, erythroblastic leukaemia, and fibroblasts were used as target cells. The cytotoxic activity was assessed using a cytotoxic test based on the selective ability to live cells to reduce MTT (3-[4, 5-dimethyltriazol-2-yl]-2, 5 diphenyltetrazolium bromide) to formazan in mitochondria. Quantitative determination of formazan was performed using spectrophotometry. RESULTS: A direct cytotoxic effect of the phytocomplex in concentrations of at least 2.5 mg/ml on tumour cells has been established. Its modulating effect on the cytotoxic activity of mononuclear blood cells at a concentration of 0.05 mg/ml was shown. The phytocomplex in doses of 0.25 and 0.5 mg/ml increased the killer activity of the mononuclear cells in a diseased person's blood, but did not affect these blood cells in a healthy donor. Incubation of lymphocytes with a phytocomplex for 24 hours increased the cytotoxic activity of mononuclear cells by 20-25%. CONCLUSION: The direct cytotoxic effect of the phytocomplex and its modulating effect on the cytotoxic activity of mononuclear blood cells in model experiments in vitro have been established.

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Busato, Isabella, Oriana Bertaiola, Silvio Tundo, Chiara Guarnerio, Marco Lucchetta, Luca Sella, Giovanna Pressi et Francesco Favaron. « A Phytocomplex Obtained from Salvia officinalis by Cell Culture Technology Effectively Controls the Grapevine Downy Mildew Pathogen Plasmopara viticola ». Plants 11, n^o 20 (11 octobre 2022) : 2675. http://dx.doi.org/10.3390/plants11202675.

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The negative impact of using conventional fungicides in plant disease protection has increased the interest in safer alternatives such as plant secondary metabolites, generally having a better toxicological profile. However, cultivation conditions and plant material strongly affect the quality and quantity of secondary metabolites obtained from field grown plants, limiting the standardization needed for industrial production. Plant cell culture technology can provide highly homogeneous biomasses with specific chemical characteristics. A phytocomplex with high rosmarinic acid content (10.12% w/w) was obtained from a selected cell line of Salvia officinalis and was tested against the grapevine downy mildew pathogen, Plasmopara viticola. Grapevine leaf discs were sprayed with the phytocomplex at 5 g/L and then inoculated with P. viticola sporangia. Sporulation level on each disc was assessed after 7 days with an image processing software. The phytocomplex reduced by 95% the sporulation level compared to the control and was also more effective than rosmarinic acid alone, used at the same concentration found in the phytocomplex. Persistence of the phytocomplex was also assessed: when applied 5 days before inoculation, it reduced by 90% the sporulation level compared to the control. These results highlight the possibility to take advantage of cell culture techniques to produce safer pesticides with high quality standards.

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Buriani, Alessandro, Stefano Fortinguerra, Vincenzo Sorrenti, Giada Caudullo et Maria Carrara. « Essential Oil Phytocomplex Activity, a Review with a Focus on Multivariate Analysis for a Network Pharmacology-Informed Phytogenomic Approach ». Molecules 25, n^o 8 (16 avril 2020) : 1833. http://dx.doi.org/10.3390/molecules25081833.

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Thanks to omic disciplines and a systems biology approach, the study of essential oils and phytocomplexes has been lately rolling on a faster track. While metabolomic fingerprinting can provide an effective strategy to characterize essential oil contents, network pharmacology is revealing itself as an adequate, holistic platform to study the collective effects of herbal products and their multi-component and multi-target mediated mechanisms. Multivariate analysis can be applied to analyze the effects of essential oils, possibly overcoming the reductionist limits of bioactivity-guided fractionation and purification of single components. Thanks to the fast evolution of bioinformatics and database availability, disease-target networks relevant to a growing number of phytocomplexes are being developed. With the same potential actionability of pharmacogenomic data, phytogenomics could be performed based on relevant disease-target networks to inform and personalize phytocomplex therapeutic application.

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Babaskin, Dmitrii Vladimirovich, Tatiana Mikhailovna Litvinova et Liudmila Ivanovna Babaskina. « The Effect of the Phytocomplex Electrophoresis on the Clinical Symptomatology and Quality of Life of Patients with the Knee Joint Osteoarthritis ». Open Access Macedonian Journal of Medical Sciences 7, n^o 14 (13 juillet 2019) : 2236–41. http://dx.doi.org/10.3889/oamjms.2019.603.

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BACKGROUND: Improving the effectiveness of rehabilitation of patients with osteoarthritis necessitates the use of drug electrophoresis with sinusoidal modulated currents (SMC-electrophoresis) in conjunction with drug therapy. The phytocomplex is proposed for electrophoresis composed of the compared, alfalfa and hops dry extract, containing flavonoids, coumestans, polysaccharides, steroids, essential amino acids, vitamins, mineral components and causing its possible use in osteoarthritis. AIM: The research aims to study the effect of the phytocomplex SMC-electrophoresis on the clinical symptoms and quality of life of patients with the knee joint osteoarthritis. METHODS: One hundred and eight patients were randomly distributed into 3 groups (n = 36). The phytocomplex SMC-electrophoresis was assigned to the first group, the amplipulse therapy (SMC) – to the second group, and the "basic" drug therapy – to the third group. The drug therapy of the patients of the third group was comparable with the drug treatment of those in the first two groups. The concentration of phytocomplex in the working solution was 10%. The electrotherapy was carried out in the aligned SMC mode in the first and fourth kind of works. Comparative indicators were as follows: WOMAC index, pain level on a visual analogue scale (VAS), Lequesne index, joint range of motion (JROM), articular and tendon indices, quality of life as per Health Assessment Questionnaire (HAQ). RESULTS: The use of the phytocomplex SMC-electrophoresis had a more pronounced positive effect on pain, knee joint function and quality of life of the patients compared with the treatment with drugs alone or using amplitude therapy. This was especially pronounced immediately after the rehabilitation. The analgesic effect was consistently maintained in the patients of the first group for up to 6 – 12 months, the second group – up to 3 – 6 months in terms of the level of pain according to the WOMAC and Lequesne indices, VAS, articular and tendon indices. Stable results have been obtained for improving the functions of the knee joint for up to 6 – 12 months using the phytocomplex SMC-electrophoresis as per the WOMAC and Lequesne indices. In the treatment by the phytocomplex SMC-electrophoresis, no side effects were registered. CONCLUSION: The obtained results give grounds for further research on the evaluation of the effectiveness of using the phytocomplex SMC-electrophoresis in microcirculatory disorders in the affected joint, for correcting connective tissue metabolism and electrolyte metabolism in the patients with the knee joint osteoarthritis.

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Arru, Laura, Francesca Mussi, Luca Forti et Annamaria Buschini. « Biological Effect of Different Spinach Extracts in Comparison with the Individual Components of the Phytocomplex ». Foods 10, n^o 2 (9 février 2021) : 382. http://dx.doi.org/10.3390/foods10020382.

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The Mediterranean-style diet is rich in fruit and vegetables and has a great impact on the prevention of major chronic diseases, such as cardiovascular diseases and cancer. In this work we investigated the ability of spinach extracts obtained by different extraction methods and of the single main components of the phytocomplex, alone or mixed, to modulate proliferation, antioxidant defense, and genotoxicity of HT29 human colorectal cells. Spinach extracts show dose-dependent activity, increasing the level of intracellular endogenous reactive oxygen species (ROS) when tested at higher doses. In the presence of oxidative stress, the activity is related to the oxidizing agent involved (H2O2 or menadione) and by the extraction method. The single components of the phytocomplex, alone or mixed, do not alter the intracellular endogenous level of ROS but again, in the presence of an oxidative insult, the modulation of antioxidant defense depends on the oxidizing agent used. The application of the phytocomplex extracts seem to be more effective than the application of the single phytocomplex components.

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Moroșan, Elena, Ana Andreea Secăreanu, Adina Magdalena Musuc, Magdalena Mititelu, Ana Corina Ioniță, Emma Adriana Ozon, Adriana Maria Dărăban et Oana Karampelas. « Advances on the Antioxidant Activity of a Phytocomplex Product Containing Berry Extracts from Romanian Spontaneous Flora ». Processes 10, n^o 4 (25 mars 2022) : 646. http://dx.doi.org/10.3390/pr10040646.

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The present study aimed to evaluate the antioxidant properties of a phytocomplex product obtained using 10% hydroalcoholic extractive solutions, in equal proportions, from Ribes nigrum, Rubus idaeus, Rubus fruticosus and Fragaria moschata fresh fruits harvested from the spontaneous flora of Romania. These plant products were recognized for their rich antioxidant content. The phytochemical profile was assessed using HPLC chromatography and UV-Vis spectrometry. The obtained results highlighted the presence of complex bioactive compounds with antioxidant actions, namely anthocyanins, proanthocyanins and vitamin C. The antioxidant actions of the hydroalcoholic extractive solutions and the phytocomplex product were evaluated using chemiluminescence, electrochemical and superoxide dismutase (SOD) methods. The experimental results showed evident antioxidant activity in both the hydroalcoholic extracts and the phytocomplex product.

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Pressi, Giovanna, Oriana Bertaiola, Chiara Guarnerio, Elisa Barbieri, Flavia Guzzo, Caroline Durand, Laurent Peno-Mazzarino, Veronica Cocetta, Isabella Giacomini et Alessandra Semenzato. « In Vitro Cultured Melissa officinalis Cells as Effective Ingredient to Protect Skin against Oxidative Stress, Blue Light, and Infrared Irradiations Damages ». Cosmetics 8, n^o 1 (15 mars 2021) : 23. http://dx.doi.org/10.3390/cosmetics8010023.

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Skin is being increasingly exposed to artificial blue light due to the extensive use of electronic devices, which can induce cell oxidative stress, causing signs of early photo aging. The Melissa officinalis phytocomplex is a new standardized cosmetic ingredient obtained by an in vitro plant cell culture with a high content of rosmarinic acid. In this study, we examine the activity of the Melissa officinalis phytocomplex to protect skin against blue light and infrared damages, evaluating the ROS (Radical Oxygen Species) level in keratinocyte cell line from human skin (HaCaT) and Nrf2 (Nuclear factor erythroid 2-related factor 2), elastin, and MMP1 (Matrix Metalloproteinase 1) immunostaining in living human skin explants ex vivo. This phytocomplex demonstrates antioxidant activity by reducing ROS production and thus the oxidant damage of the skin caused by UV and blue light exposure. In addition, it inhibits blue light-induced Nrf2 transcriptional activity, IR-induced elastin alteration, and IR-induced MMP-1 release. This Melissa officinalis phytocomplex is a new innovative active ingredient for cosmetic products that is able to protect skin against light and screen exposure damages and oxidative stress.

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Pressi, Giovanna, Giovanna Rigillo, Paolo Governa, Vittoria Borgonetti, Giulia Baini, Raffaella Rizzi, Chiara Guarnerio et al. « A Novel Perilla frutescens (L.) Britton Cell-Derived Phytocomplex Regulates Keratinocytes Inflammatory Cascade and Barrier Function and Preserves Vaginal Mucosal Integrity In Vivo ». Pharmaceutics 15, n^o 1 (10 janvier 2023) : 240. http://dx.doi.org/10.3390/pharmaceutics15010240.

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In the last years, the medicinal plant Perilla frutescens (L.) Britton has gained scientific interest because leaf extracts, due to the presence of rosmarinic acid and other polyphenols, have shown anti-allergic and skin protective potential in pre-clinical studies. Nevertheless, the lack of standardized extracts has limited clinical applications to date. In this work, for the first time, a standardized phytocomplex of P. frutescens, enriched in rosmarinic acid and total polyphenols, was produced through innovative in vitro cell culture biotechnology and tested. The activity of perilla was evaluated in an in vitro inflammatory model of human keratinocytes (HaCaT) by monitoring tight junctions, filaggrin, and loricrin protein levels, the release of pro-inflammatory cytokines and JNK MAPK signaling. In a practical health care application, the perilla biotechnological phytocomplex was tested in a multilayer model of vaginal mucosa, and then, in a preliminary clinical observation to explore its capacity to preserve vaginal mucosal integrity in women in peri-menopause. In keratinocytes cells, perilla phytocomplex demonstrated to exert a marked activity in epidermis barrier maintenance and anti-inflammatory effects, preserving tight junction expression and downregulating cytokines release through targeting JNK activation. Furthermore, perilla showed positive effects in retaining vaginal mucosal integrity in the reconstructed vaginal mucosa model and in vivo tests. Overall, our data suggest that the biotechnological P. frutescens phytocomplex could represent an innovative ingredient for dermatological applications.

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Simonova, Tatiana, Natalia Efimenko, Vyacheslav Nastyukov et Arthur Mkrtchyan. « Metaphylaxis of urolithiasis in shipboard personnel with rational pharmacotherapy in resort conditions ». Fizioterapevt (Physiotherapist), n^o 1 (1 février 2020) : 4–10. http://dx.doi.org/10.33920/med-14-2002-01.

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The report is dedicated to the new medical technology of sanatorium-resort treatment and metaphylaxis of urolithiasis developed in our resort using Slavyanovskaya mineral water drinking, mineral baths and rational pharmacotherapy (Urolit phytocomplex). Comprehensive SPA therapy of urolithiasis with internal and external (bath) use of Slavyanovskaya mineral water in combination with the Urolit phytocomplex compared to traditional spa treatments contributes to a more pronounced favourable dynamics of the indicators of the functional state of kidneys, correction of metabolic disorders, increased glomerular filtration, increased diuresis and normalization of urodynamics, which are important links in the metaphylaxis of urolithiasis.

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Gilmutdinova, Lira Talgatovna, Rushaniya Ravilievna Kudayarova, Aleksander Mikhailovich Ivanov, Ruslan Ralifovich Garaev, Bulat Rashitovich Gilmutdinov, Ekaterina Alekseevna Marakaeva et Liana Mudarisovna Kamilyanova. « Application of phytocomplex and nordic walking in dyslipidemia ». Fizioterapevt (Physiotherapist), n^o 6 (4 décembre 2021) : 48–54. http://dx.doi.org/10.33920/med-14-2112-05.

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The results of assessing the effectiveness of using the original phytocomplex in combination with physical training in the form of Nordic walking in 78 men with dyslipidemia are presented. It was found that in the main group (n=39), against the background of the use of phytocomplex and physical training, there is a decrease in the content of atherogenic lipid fractions and the atherogenic coefficient, an increase in physical performance, and an improvement in the indicators of the adaptive reserve of the cardiovascular system. In the control group (n=39), against the background of a hypolipidemic diet and climatotherapy, less significant dynamics of the parameters is noted.

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Borgonetti, Vittoria, Paolo Governa, Monica Montopoli et Marco Biagi. « Cannabis sativa L. Constituents and Their Role in Neuroinflammation ». Current Bioactive Compounds 15, n^o 2 (12 mars 2019) : 147–58. http://dx.doi.org/10.2174/1573407214666180703130525.

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The interest in Cannabis sativa L. phytocomplex as a medicinal tool is a recently-emerging topic. Neurodegenerative diseases represent a promising field of application for cannabis and its preparations, as most of this pathologic conditions relies on an inflammatory etiology. Several cannabis constituents display anti-inflammatory effects targeting multiple pathways. In this review, a comprehensive overview of the available literature on C. sativa constituents activities in neuroinflammation is given. On the basis that the anti-inflammatory activity of cannabis is not attributable to only a single constituent, we discuss the possible advantages of administering the whole phytocomplex in order to fully exploit the “entourage effect” in neuroinflammatory-related conditions.

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Ivanovskiy, A. A., et N. A. Latushkina. « APPLICATION OF THE FEED ADDITIVE WITH S.CORONATA IN THE RATION OF CALVES AND COWS ». Vestnik of Ulyanovsk state agricultural academy 230 (25 septembre 2021) : 200–205. http://dx.doi.org/10.18286/1816-4501-2021-3-200-205.

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The aim of the research is to study the effect of “Phytocomplex S. coronata” supplement on clinical and biochemical status of calves, blood morphology and productivity of dairy cows. The content of ecdysteroids in the additive was determined by highly-efficient liquid chromatography. The experiments were organized in Kirov region. One control and three experimental groups of calves at the age of 1.5 months were selected. Each group included 10 heads. Phytocomplex S. coronata was mixed with water and given to calves for 30 days: group 1 - 10 g, group 2 - 20 g, group 3 - 30 g / calf. Phytocomplex S.coronata was given in the experiment on lactating cows once a day for 60 days: group 1 - 50 g, group 2 - 100 g and group 3 - 150 g / head. Animals in the control were kept on the farm ration without additives. Blood tests of calves (total protein, albumin, ALT, urea, total cholesterol, sublimate test, reserve alkalinity) and cows (erythrocytes, leukocytes, hemoglobin) were carried out at the beginning and at the end of the experiments. It was found that the concentration of ecdysteroids is 500 mg / kg in Phytocomplex S. coronata. The amount of total protein in the blood of calves from the experimental groups increased to 65.7 ± 4.2 - 68.0 ± 2.5 g / l (P <0.05), albumin to 31.5 ± 1.2 - 33.2 ± 1.2 g / l (P <0.05). By the end of the experiment, the average daily milk yield of cows in the experimental groups exceeded the result in the control by 3.7%, milk fat by 0.3%, protein by 0.6%. (P <0.05). By the end of the experiment, the number of erythrocytes and hemoglobin in the blood of cows of the experimental groups significantly (P <0.05) exceeded these parameters at the beginning of the experiment, while in the control there were no significant changes (P> 0.05).

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Golovey, V. V., G. N. Vyayzenen et A. V. Golovey. « Water-soluble vitamins in the feed of high-yield lactating cows during the milking period ». BIO Web of Conferences 52 (2022) : 00002. http://dx.doi.org/10.1051/bioconf/20225200002.

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The aim of the work is to show how to increase the productivity of cows, to improve the feeding system, to introduce intensive, promising, effective, resource-saving milk production technologies, including the implementation of measures for the production and use of domestic vitamin feed products (preparations). The studies were carried out by the example of highly productive dairy cows with an annual productivity of over 6000 kg of milk per lactation. The type of feeding is the silage – hayage silage concentrate, the rations are balanced in terms of nutrients, biologically active substances and metabolic energy. It corresponded to the generally accepted norms of animal feeding in the country (M., RAAS, 2003). The diets of cows during the milking period included Vitaminol and a phytocomplex (of 13 medicinal forage herbs), 10 g, 15 g and 20 g per head per day. When milking cows (100 days), fed with Vitaminol, more milk was produced ranging from 2.7 to 9.9 %, the phytocomplex increased milk yield from 8.4 to 16.3 %. The consumption of metabolic energy of diets per 1 kg of milk is lower in cows of the experimental groups when using different doses of Vitaminol ranging from 2.8 to 9.9 %, and the phytocomplex allowed ranging it from 8.3 to 16.1 % compared to the control variant. To increase metabolic processes in the body, productivity and supply of water-soluble vitamins and mineral macronutrients in cows under the conditions of a year-round stable method of keeping, the rations included the optimal dose of Vitaminol and the phytocomplex (separately) amounting to 20 g per head a day. Vitaminol serves to replenish the body of highly productive lactating cows during the period of milk production with missing biologically active substances, vitamin nutritional value of milk, increase the digestibility of organic substances in rations, and improve metabolic processes.

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Sandakova, E. A., Yu V. Rakitina, E. Yu Kapustina, E. Yu Kotovskaya et O. S. Simonova. « Experience of using domestic phytocomplex in treatment of patients with benign hyperplastic processes of reproductive system ». Perm Medical Journal 35, n^o 4 (15 décembre 2018) : 5–13. http://dx.doi.org/10.17816/pmj3545-13.

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Aim. To estimate the clinical efficiency of phytocomplex “Flavopersin”. Materials and methods. Phytotherapy is one of advanced directions in modern medicine. Fifty women with clinicoechographic signs of benign hyperplastic diseases of reproductive system were examined and treated. The methods of study included: registration of complaints and anamnesis data, standard general clinical examination and gynecological study; instrumental methods of investigation included: pelvic and mammary ultrasound using Siemens Sonoline Elegra with vaginal sensor of 6,5 MHz. The methods of study also contained assessment of pelvic pain and mastalgia by Visual Analogue Scale (VAS). Results. After completing the therapy during six menstrual cycles, a positive effect in treatment of dysmenorrhea, significant reduction of mastalgia manifestation as well as reliable decrease in anterior-posterior uterine size and optimization of endometrial structure by pelvic US data was reached. Besides, phytocomplex permitted to reduce anxiety, tension, to raise activity, mood, psychological stress tolerance and social adaptation that improved the quality of life among patients. Conclusions. The therapy, including phytocomplex “Flavopersin” is a method, which promotes intensification of the effect of drug therapy, increases the interval between hormonal therapy courses and, thus, reduces the manifestation of its side effects and improves patients’ health status at the expense of optimization of psycho-emotional status.

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Gurzhenko, Yu M. « MODERN PHYTOTHERAPEUTIC APPROACHES IN ANDROLOGICAL PRACTICE ». Problems of Endocrine Pathology 33, n^o 3 (12 octobre 2010) : 51–56. http://dx.doi.org/10.21856/j-pep.2010.3.08.

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The paper presents a positive experience of using the phytocomplex Kamavit forte by Nutrimed (Ukraine) in the treatment of erectile dysfunction. The efficiency of phytopreparation treatment was 88.9%.

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Carrasco-Gallardo, Carlos, Leonardo Guzmán et Ricardo B. Maccioni. « Shilajit : A Natural Phytocomplex with Potential Procognitive Activity ». International Journal of Alzheimer's Disease 2012 (2012) : 1–4. http://dx.doi.org/10.1155/2012/674142.

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Shilajitis a natural substance found mainly in the Himalayas, formed for centuries by the gradual decomposition of certain plants by the action of microorganisms. It is a potent and very safe dietary supplement, restoring the energetic balance and potentially able to prevent several diseases. Recent investigations point to an interesting medical application toward the control of cognitive disorders associated with aging, and cognitive stimulation. Thus, fulvic acid, the main active principle, blocks tau self-aggregation, opening an avenue toward the study of Alzheimer's therapy. In essence, this is a nutraceutical product of demonstrated benefits for human health. Considering the expected impact ofshilajitusage in the medical field, especially in the neurological sciences, more investigations at the basic biological level as well as clinical trials are necessary, in order to understand how organic molecules ofshilajitand particularly fulvic acid, one of the active principles, and oligoelements act at both the molecular and cellular levels and in the whole organism.

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Malgeri, Andrea, Giuseppe Vassalotti, Raffaele Maglione et Nadia Musco. « Agility Dog : An Innovative Phytocomplex to Improve Performance ». Journal of Nutritional Ecology and Food Research 5, n^o 1 (1 juin 2018) : 71–74. http://dx.doi.org/10.1166/jnef.2018.1176.

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Tomasello, Barbara, Giuseppe Antonio Malfa, Rosaria Acquaviva, Alfonsina La Mantia et Claudia Di Giacomo. « Phytocomplex of a Standardized Extract from Red Orange (Citrus sinensis L. Osbeck) against Photoaging ». Cells 11, n^o 9 (25 avril 2022) : 1447. http://dx.doi.org/10.3390/cells11091447.

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Excessive exposure to solar radiation is associated with several deleterious effects on human skin. These effects vary from the occasional simple sunburn to conditions resulting from chronic exposure such as skin aging and cancers. Secondary metabolites from the plant kingdom, including phenolic compounds, show relevant photoprotective activities. In this study, we evaluated the potential photoprotective activity of a phytocomplex derived from three varieties of red orange (Citrus sinensis (L.) Osbeck). We used an in vitro model of skin photoaging on two human cell lines, evaluating the protective effects of the phytocomplex in the pathways involved in the response to damage induced by UVA-B. The antioxidant capacity of the extract was determined at the same time as evaluating its influence on the cellular redox state (ROS levels and total thiol groups). In addition, the potential protective action against DNA damage induced by UVA-B and the effects on mRNA and protein expression of collagen, elastin, MMP1, and MMP9 were investigated, including some inflammatory markers (TNF-α, IL-6, and total and phospho NFkB) by ELISA. The obtained results highlight the capacity of the extract to protect cells both from oxidative stress—preserving RSH (p < 0.05) content and reducing ROS (p < 0.01) levels—and from UVA-B-induced DNA damage. Furthermore, the phytocomplex is able to counteract harmful effects through the significant downregulation of proinflammatory markers (p < 0.05) and MMPs (p < 0.05) and by promoting the remodeling of the extracellular matrix through collagen and elastin expression. This allows the conclusion that red orange extract, with its strong antioxidant and photoprotective properties, represents a safe and effective option to prevent photoaging caused by UVA-B exposure.

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Tomasello, Barbara, Giuseppe Antonio Malfa, Rosaria Acquaviva, Alfonsina La Mantia et Claudia Di Giacomo. « Phytocomplex of a Standardized Extract from Red Orange (Citrus sinensis L. Osbeck) against Photoaging ». Cells 11, n^o 9 (25 avril 2022) : 1447. http://dx.doi.org/10.3390/cells11091447.

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Excessive exposure to solar radiation is associated with several deleterious effects on human skin. These effects vary from the occasional simple sunburn to conditions resulting from chronic exposure such as skin aging and cancers. Secondary metabolites from the plant kingdom, including phenolic compounds, show relevant photoprotective activities. In this study, we evaluated the potential photoprotective activity of a phytocomplex derived from three varieties of red orange (Citrus sinensis (L.) Osbeck). We used an in vitro model of skin photoaging on two human cell lines, evaluating the protective effects of the phytocomplex in the pathways involved in the response to damage induced by UVA-B. The antioxidant capacity of the extract was determined at the same time as evaluating its influence on the cellular redox state (ROS levels and total thiol groups). In addition, the potential protective action against DNA damage induced by UVA-B and the effects on mRNA and protein expression of collagen, elastin, MMP1, and MMP9 were investigated, including some inflammatory markers (TNF-α, IL-6, and total and phospho NFkB) by ELISA. The obtained results highlight the capacity of the extract to protect cells both from oxidative stress—preserving RSH (p < 0.05) content and reducing ROS (p < 0.01) levels—and from UVA-B-induced DNA damage. Furthermore, the phytocomplex is able to counteract harmful effects through the significant downregulation of proinflammatory markers (p < 0.05) and MMPs (p < 0.05) and by promoting the remodeling of the extracellular matrix through collagen and elastin expression. This allows the conclusion that red orange extract, with its strong antioxidant and photoprotective properties, represents a safe and effective option to prevent photoaging caused by UVA-B exposure.

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Mastellone, Giulia, Arianna Marengo, Barbara Sgorbini, Federica Scaglia, Francesca Capetti, Francesco Gai, Pier Giorgio Peiretti, Patrizia Rubiolo et Cecilia Cagliero. « Characterization and Biological Activity of Fiber-Type Cannabis sativa L. Aerial Parts at Different Growth Stages ». Plants 11, n^o 3 (3 février 2022) : 419. http://dx.doi.org/10.3390/plants11030419.

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Currently, there is a renewed interest in cannabis-related products in different fields because of the rich phytocomplex of this plant, together with its fiber and agricultural features. In this context, the current study aims to chemically characterize different samples of fiber-type Cannabis sativa L. grown in Italy as a potential health promoting source. An ultrasound-assisted solid-liquid extraction (UA-SLE) method was first developed and optimized to obtain a fingerprinting of the investigated phytocomplex. Analyses were carried out through an ultra high performance liquid chromatography equipped with a photodiode array detector in series with triple quadrupole system with an electrospray ionization (ESI) interface (UHPLC-UV-ESI-MS/MS) and showed that the phytocomplex mainly includes flavonoids and non-psychotomimetic cannabinoids. The method was then applied to characterize and compare 24 samples of fiber-type Cannabis sativa L. aerial parts (mainly stems and leaves), which differed for the growth stages (from mid-vegetative to early flowering), growth land plots, and methods of drying (forced-draft oven or freeze-drying). The quali-quantitative analysis showed that a freeze-drying method seems to better preserve the chemical composition of the samples, while the location of the land plot and the growth stage of the plant (which did not comprise inflorescences) had minor influences on the chemical pattern. These results were also supported by spectrophotometric in-vitro assays (scavenging of 2,2-diphenyl-1-picrylhydrazyl (DPPH•) and 2,2′-azinobis-3-ethyl-benzthiazoline-6-sulphonate (ABTS+•) radicals and inhibitory activity against tyrosinase and elastase enzymes) to investigate the potential biological activity of these samples and the contribution of non-psychotomimetic cannabinoids.

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Moskalyuk, O., et A. Haschuk. « DEVELOPMENT OF PÂTÉ USING THE СНОІСЕ PHYTOCOMPLEX OF CEREAL CULTURES ». Scientific Works of National University of Food Technologies 23, n^o 4 (août 2017) : 238–43. http://dx.doi.org/10.24263/2225-2924-2017-23-4-31.

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Di Vito, Maura, Margherita Gentile, Paola Mattarelli, Lorenzo Barbanti, Laura Micheli, Claudia Mazzuca, Stefania Garzoli et al. « Phytocomplex Influences Antimicrobial and Health Properties of Concentrated Glycerine Macerates ». Antibiotics 9, n^o 12 (1 décembre 2020) : 858. http://dx.doi.org/10.3390/antibiotics9120858.

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The purpose of this study was to correlate the chemical composition of four commercial concentrated glycerine macerates (C-GMs), produced through the same extraction method, with their in vitro antimicrobial, antioxidant, and immunomodulatory properties, in order to evaluate their potential for healing upper airway diseases. C-GMs of Carpinus betulus (CB), Ficus carica (FC), Alnus glutinosa (AG) and Ribes nigrum (RN) were studied. The quality was evaluated using HPLC and IM-SPME/GC-MS systems; anti-oxidant and anti-microbial activities were assessed by the respective DPPH test, and micro-broth dilution test performed against 10 strains of Streptococcus pyogenes and 10 probiotic strains. ELISA and MTT tests were used to assess the immunomodulatory activity and the cytotoxicity of C-GMs, respectively. A significant correlation was found between the number of active compounds and the in vitro C-GMs effectiveness. Furthermore, the C-GMs of AG showed the best anti-microbial activity on pathological strains and, together with CB, the best anti-oxidant activity. The ELISA test exhibited a good immunomodulatory activity of RN. In vitro data support the integrated use of C-GMs of CB, AG, and RN in presence of airway diseases, and highlight the importance of standard procedures in cultivation, harvest and post-harvest treatments, as a premise for C-GMs with consistent characteristics.

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Iosio, T., D. Voinovich, B. Perissutti, F. Serdoz, D. Hasa, I. Grabnar, S. Dall’ Acqua, G. P. Zara, E. Muntoni et J. F. Pinto. « Oral bioavailability of silymarin phytocomplex formulated as self-emulsifying pellets ». Phytomedicine 18, n^o 6 (avril 2011) : 505–12. http://dx.doi.org/10.1016/j.phymed.2010.10.012.

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Kravchun, N. A., et Irina Cherniavskaya. « HYPOTHYROIDISM : EPIDEMIOLOGY, DIAGNOSTICS, TREATMENT EXPERIENCE ». Problems of Endocrine Pathology 37, n^o 3 (27 septembre 2011) : 27–34. http://dx.doi.org/10.21856/j-pep.2011.3.05.

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The efficiency of the phytocomplex "Zobofit" was studied in patients with hypothyroidism. It is shown that the use of "Zobofit" improves the structure of the thyroid gland, normalizes the indicators of the functional activity of the pituitary-thyroid system. It is possible to reduce the dosage of thyroid hormones when using “Zobofit” in the complex therapy of hypothyroidism

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Neymark, Aleksandr I., Boris A. Neymark, Nikolay A. Nozdrachev, Michail Y. Gatkin et Yulia S. Fursa. « The effect of the phytocomplex Renotineх® on postoperative period after external shock wave lithotripsy in patients with urolithiasis ». Urology reports (St. - Petersburg) 11, n^o 1 (27 mai 2021) : 49–54. http://dx.doi.org/10.17816/uroved34756.

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INTRODUCTION: Phytopreparations are one of the leading medicines used as preoperative preparation and postoperative management in patients with urolithiasis. THE AIM of the study was to evaluate the nephroprotective effect of Renotinex in patients with urolithiasis after extracorporeal shock wave lithotripsy (ESWL). MATERIALS AND METHODS: The study included 86 patients (43 in the main and the comparison group) with urolithiasis with localization of the stone in the renal pelvis without disturbing the outflow of urine. All patients underwent extracorporeal shock wave lithotripsy (ESWL). After ESWL patients in both groups received spasmodic, anti-inflammatory, antibacterial therapy. Patients of the main group additionally received Renotinex 2 capsules 3 times a day for 14 days before and 14 days after surgery. RESULTS: During the observation a more effective discharge of calculus fragments was noted in patients of the main group while taking the phytocomplex Renotinex, as well as less pronounced damage and faster recovery of the renal parenchyma after ESWL according to the level of enzimuria. CONCLUSION: The results of the study indicate the feasibility of prescribing the phytocomplex Renotinex for nephroprotective and lithokinetic therapy in patients after ESWL.

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Ferron, Lucia, Raffaella Colombo, Barbara Mannucci et Adele Papetti. « A New Italian Purple Corn Variety (Moradyn) Byproduct Extract : Antiglycative and Hypoglycemic In Vitro Activities and Preliminary Bioaccessibility Studies ». Molecules 25, n^o 8 (23 avril 2020) : 1958. http://dx.doi.org/10.3390/molecules25081958.

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The reuse of byproducts from agricultural and food industries represents the key factor in a circular economy, whose interest has grown in the last two decades. Thus, the extraction of bioactives from agro-industrial byproducts is a potential source of valuable molecules. The aim of this work was to investigate the in vitro capacity of byproducts from a new Italian corn variety, named Moradyn, to inhibit the accumulation of advanced glycation end products (AGEs) involved in several chronic age-related disorders. In addition, the hypoglycemic effect of Moradyn was tested by in vitro enzymatic systems. A Moradyn phytocomplex and its purified anthocyanin fraction were able to inhibit fructosamine formation and exhibited antiglycative properties when tested using BSA-sugars and BSA-methylglyoxal assays. These properties could be attributed to the polyphenols, mainly anthocyanins and flavonols, detected by RP-HPLC-DAD-ESI-MSn. Finally, a Moradyn phytocomplex was submitted to a simulated in vitro digestion process to study its bioaccessibility. Moradyn could be considered as a promising food ingredient in the context of typical type 2 diabetes risk factors and the study will continue in the optimization of the ideal formulation to preserve its bioactivities from digestion.

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De Martin, Sara, Daniela Gabbia, Maria Carrara et Nicola Ferri. « The Brown Algae Fucus vesiculosus and Ascophyllum nodosum Reduce Metabolic Syndrome Risk Factors : A Clinical Study ». Natural Product Communications 13, n^o 12 (décembre 2018) : 1934578X1801301. http://dx.doi.org/10.1177/1934578x1801301228.

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Fucus vesiculosus and Ascophyllum nodosum have been traditionally used for the treatment of obesity and several gastrointestinal diseases. We have recently demonstrated that the phytocomplex obtained from these algae (Gdue™) controls postprandial glucose levels in a mouse model of steatohepatitis, a condition often associated with obesity and type 2 diabetes mellitus. We analyzed the effect of Gdue™ on HOMA index, waist circumference, fasting blood glucose and insulin levels in overweight or obese subjects. Waist circumference decreased significantly after 6 months of treatment (112 ± 17 at t0 vs 105 ± 13 cm after 6 months of treatment; p<0.0001). Both blood glucose and insulin levels were significantly reduced after 6 months of treatment with Gdue™ (110 ± 15 at t0 vs 98 ± 15 mg/dL after 6 months for glucose; p<0.0001; 22.6 ± 9.5 at t0 vs 17.8 ± 8.6 μU/mL after 6 months for insulin; p<0.05). Accordingly, HOMA index decreased significantly (6.103 ± 2.548 at t0 vs 4.419 ± 2.382 after 6 months; p<0.01), suggesting an improvement of insulin sensitivity status. This phytocomplex represents a useful dietary supplement for controlling relevant metabolic syndrome risk factors, such as waist circumference, fasting insulin and glucose levels.

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Pressi, Giovanna, Elisa Barbieri, Raffaella Rizzi, Giovanni Tafuro, Alessia Costantini, Elisa Di Domenico et Alessandra Semenzato. « Formulation and Physical Characterization of a Polysaccharidic Gel for the Vehiculation of an Insoluble Phytoextract for Mucosal Application ». Polysaccharides 3, n^o 4 (9 novembre 2022) : 728–44. http://dx.doi.org/10.3390/polysaccharides3040042.

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Maintaining insoluble plant-based ingredients in suspension and ensuring long-term physical stability is particularly challenging for formulators of green cosmetics. This study aimed to evaluate the structure and applicative properties of gel and gel-cream topical formulations suitable for delivering an insoluble phytocomplex on the vaginal mucosa and maintaining its integrity. For this purpose, we studied the compatibility of Perilla frutescens (L.) Britton phytocomplex (PFP), derived from in vitro plant cell cultures and presented as a powder finely dispersed in glycerin, with different classes of natural rheological modifiers (such as xanthan gum, sclerotium gum, succinoglycan, xyloglucan, diutan gum, hydroxypropyl guar gum derivative) in gel and gel-cream formulations, to meet the needs of the cosmetic market for naturalness and biodegradability. Through rheological and texture analyses, we studied the physico–mechanical properties of the samples, comparing the performances of the chosen polysaccharides to those of acrylic polymeric rheological modifiers, evaluating their contribution in terms of stability and applicative properties. Since a weak-gel rheological pattern proved to be the optimal one to keep the actives in suspension, the associations of tamarind seed polysaccharides with succinoglycan or scleroglucan were the most suitable for the formulation of mucoadhesive gels.

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Golovey, V. V., G. N. Vyayzenen et A. V. Golovey. « Use of fat-soluble vitamins and feed additives in cow diets ». BIO Web of Conferences 52 (2022) : 00001. http://dx.doi.org/10.1051/bioconf/20225200001.

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The authors have created modern effective methods for controlling the vitamin content of highly productive lactating cows during the first period of lactation. The results were obtained on the content of vitamins in the diet, milk and blood when feeding with supplements Vitaminol and phytocomplex at 10, 15 and 20 g per animal unit daily separately and with mixed feed. The authors monitored the levels of vitamins A, carotene, D and E in cow's milk and serum. Scientific research was carried out for the agricultural enterprise "Novgorodsky Becon" of the Novgorod region. The cows ration was balanced by 50 nutrients and biologically active substances in accordance with the recommendations for animal feeding (Moscow, Russian Academy of Agricultural Sciences, 2003). Studies of the content of vitamins were carried out using the silage-concentration type of ration fed to lactating black-and-white cows in conditions without grazing. We conducted 2 scientific experiments and 2 physiological experiments with cows during the first 100 days of their lactation. The increase in the level of vitamin A in milk and blood was due to the use of feed additives in the diets. The use of feed additives increased the vitamin D levels in milk and serum. The balance of calcium and phosphorus metabolism in cows is positive. The use of "Vitaminol" together with compound feeds increased the level of calcium by 5.6 6.3 and phosphorus by 4.4 4.9 grams per 1 kg of milk with the natural fat content. The diets were admixed with the "Vitaminol" and phytocomplex ratio of Ca: P (1.3: 1) and Na: K (0.2: 1). With the same doses of feed additives, the ratio of acid and alkaline elements in the diets was the same: Vitaminol was 0.743 and phytocomplex was 0.709. Due to the use of "Vitaminol", the concentration of vitamin E in milk is 4.6-6 times higher than that in the control group, in blood and blood serum.

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Morano, Camillo, Michele Dei Cas, Gabriella Roda, Adalberto Fabbriconi, Eleonora Casagni, Marco Pallavicini, Cristiano Bolchi, Gloria Pallotti, Francesco Romaniello et Pierangela Rovellini. « The Antioxidant Role of Hemp Phytocomplex in Cannabis Oil-Based Extracts ». Pharmaceuticals 15, n^o 9 (4 septembre 2022) : 1102. http://dx.doi.org/10.3390/ph15091102.

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The therapeutic use of Cannabis oil extracts is constantly increasing. However, in Italy, they are allowed to be prepared with only a few methods and matrices. With this work, we aimed to assess how the different processes might affect the chemical composition of two different matrices (olive oils and medium chain triglycerides oils - MCT), accounting as variables for both the presence of Cannabis dried apices of the female flower and the adding of tocopherol acetate as an antioxidant. The macerated oils were prepared with four of the methods allowed according to the Italian legislation (Romano-Hazekamp, Cannazza-Citti, SIFAP and Calvi) and analyzed for normal and oxidized tocopherols, oxidized and conjugated fatty acids and volatile carbonyl compounds (VCCs), all using liquid chromatography coupled to UV or PDA detectors. According to our results, neither normal nor oxidized tocopherols are affected by the addition of antioxidants or Cannabis, while the oxidation state (according to the levels of oxidized and conjugated fatty acids) is often altered in either case. The VCCs concentrations, on the other hand, are never notably altered. These results suggest a worthless use of antioxidants in Cannabis macerated oils preparations, while the dried apices of female flowers might have a protective role in maintaining the oil oxidation state.

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Giordano, Maria, Giovanni Luongo, Sergio Davinelli, Afef Ladhari, Giuseppina Rita Nappo et Maddalena Giordano. « Silybum marianum : not Just Silymarin and Flavonolignans- ». Records of Natural Products 15, n^o 4 (17 avril 2021) : 243–53. http://dx.doi.org/10.25135/rnp.219.20.09.1827.

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The use of Silybum marianum L. for therapeutic purposes has been known since ancient times. Its phytocomplex reduces transaminases and other biohumoral indices in the course of liver disease and also in hepato-renal syndrome. In particular, the flavonolignan component has shown properties that would partially explain the ability of the phytocomplex to induce a certain regeneration of liver cells, stimulate the cellular elimination of toxins and reduce the inflammatory component, present in fatty, alcoholic and hormonal therapies with steroids. S. marianum is also successfully used in the treatment of patients with symptomatic chronic hepatitis, with complete disappearance of clinical symptoms, such as asthenia, loss of appetite, severe meteorism, dyspepsia, and with normalization of transaminases. The same results can be obtained in patients undergoing heavy chemotherapy cycles. Modern herbal medicine uses it in decoction or infusion, however with some caution in patients suffering from hypertension, due to the presence of tyramine. In addition, the extracts of the roots have antioxidant, diuretic and febrifugal properties and those of the leaves have aperitif properties. It is therefore interesting to provide a picture of the different non-flavonolignanic components (terpenes, steroids and essential oils) of the plant and their properties, which have perhaps been wrongly neglected over the past few years.

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Rombolà, Laura, Marilisa Straface, Damiana Scuteri, Tsukasa Sakurada, Shinobu Sakurada, Maria Tiziana Corasaniti, Giacinto Bagetta et Luigi Antonio Morrone. « Antispasmodic Effect of Bergamot Essential Oil on Rat Isolated Gut Tissues ». Pharmaceutics 14, n^o 4 (2 avril 2022) : 775. http://dx.doi.org/10.3390/pharmaceutics14040775.

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Preclinical data indicate that bergamot essential oil (BEO) can modulate the synaptic functions within the central nervous system (CNS). Particularly, several data shows that essential oil is endowed with reproducible analgesic and anxiolytic effects that may derived from the ability to modulate the excitatory and inhibitory neurotransmission in the CNS. Although there are differences in the functional complexity of the enteric nervous system (ENS), it is likely that the phytocomplex has biological properties in gut superimposable to those showed in the CNS. Accordingly, the aim of this study was to investigate ex-vivo the effect of bergamot essential oil and its main constituents on the contractile activity of rat isolated colon, jejunum and ileum induced by different muscle stimulants such as acetylcholine (10−6 M) and potassium chloride (80 mM). Our present data demonstrate that BEO inhibits cholinergically- and non cholinergically-mediated contractions in rat isolated gut and that linalool is the most active component. These results suggest that the phytocomplex might be useful in the treatment of spastic disorders in ENS mainly characterized by the presence of pain; incidentally, irritable bowel syndrome (IBS) is a painful condition in which a role for neurotransmitter dysfunction has been envisaged. More investigation is required for clinical translation of the present data.

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Fodaroni, Giada, Michela Burico, Anna Gaetano, Anna Maidecchi, Rita Pagiotti, Luisa Mattoli, Pietro Traldi et Eugenio Ragazzi. « An Integrated Approach to the Evaluation of a Metabolomic Fingerprint for a Phytocomplex. Focus on Artichoke [Cynara cardunculus subsp. scolymus] Leaf ». Natural Product Communications 9, n^o 4 (avril 2014) : 1934578X1400900. http://dx.doi.org/10.1177/1934578x1400900436.

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The availability of reliable herbal formulations is essential in order to assure the maximal activity and to limit unwanted side-effects. The correct concentration of declared components of herbal products is a matter of health legislation and regulation, but is still a topic under debate in the field of quality control assessment. In the present work specific constituents of artichoke leaf extracts, considered as a test herbal product, were measured by standard spectrophotometric and HPLC methods (for quantitative determination of some components only), and results were correlated with the ESI-MS (showing the full metabolomic fingerprint). Phytocomplex stability over time was also investigated in batches submitted to different storage conditions. The results indicated excellent agreement between the two approaches in the measurement of total caffeoylquinic acids and chlorogenic acid contents, but the metabolomic ESI-MS method approach provides a more complete evaluation and monitoring of the composition of a herbal product, without focusing only on a single/few compound measurements. Therefore, the ESI-MS method can be proposed for the evaluation of the quality of complex matrices, such as those in a phytocomplex. Another aspect lies in the possibility to obtain a broad-spectrum stability control of herbal formulations, requiring minimal sample pre-processing procedures.

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Korchazhkina, Natalia B., et Ruslan V. Kupeev. « Analgesia by laserophoresis of herbal extracts in treatment of patients with lumbosacral dorsopathy ». Russian Journal of Physiotherapy, Balneology and Rehabilitation 20, n^o 3 (15 mai 2021) : 193–98. http://dx.doi.org/10.17816/1681-3456-2021-20-193-198.

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BACKGROUND: The article describes the pharmaco-physiotherapeutic method of analgesia for pain in the lumbosacral spine. The possibilities of introducing the method of transcutaneous analgesia into therapy using laserophoresis of a biological complex of water extracts of field horsetail and St. John's wort are shown. These phytoextracts were used in the laser phoresis method due to the fact that they have analgesic, decongestant and adaptogenic effects, as well as reduce the metabolic activity of chemical agents, including inflammatory ones. AIMS: Study of the analgesic effect of the developed method of phytocomplex laserphoresis in comparison with the standard scheme of nonsteroidal anti-inflammatory drugs. MATERIAL AND METHODS: The study included 48 patients with a confirmed diagnosis of lumbosacral dorsopathy accompanied by pain syndrome were under observation. The main group consisted of 28 people who underwent phytocomplex laserphoresis procedures as a local treatment. The control group consisted of 20 people, where the standard treatment with NSAID drugs was prescribed. The study included observation and control before and after the course of treatment conducted in a polyclinic. To assess the severity of pain was applied to the visual analogue pain scale and the method of tensoalgometry. RESULTS: All patients underwent treatment well, there were no cases of interruption of the course of treatment. As a result of dynamic analysis of indicators performed before and after treatment, pain scale and tenzoalgometry indicators showed results indicating faster and more effective relief of pain in patients of the main study group. When summing up the results of treatment, the improvement in pain scale indicator showed an 83% improvement in the main group (p 0.05), while the improvement in the control group was only 39%. According to the control tensoalgometry, in the main group, pain thresholds improved by 32% (p 0.05), while in the control group the improvement was only 12%. CONCLUSION: The resulting analgesic effect is formed due to the anti-inflammatory effect of low-intensity laser radiation, as well as the therapeutic properties of the phytocomplex used, which can replace the use of NSAIDs for analgesia of pain in the lumbosacral region.

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Kovtun, Elena, Liudmila Pogrebnyak, Eleonora Stepanova, Andrey Pogrebnyak, Yuri Morozov et Dmitry Bokov. « Preparation of components of ultrasonic extract of ginkgo biloba, physico-chemical and pharmacological analysis and molecular design ». Archiv Euromedica 12, n^o 1 (16 janvier 2022) : 26–28. http://dx.doi.org/10.35630/2199-885x/2022/12/1.6.

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The main task arising during the processing of medicinal plant raw materials is the intensification of extraction processes in order to maximize the extraction of groups of biologically active substances. It is of interest to obtain an extract and conduct molecular modeling in order to predict the biological activity of the components of the ginkgo biloba phytocomplex. The range of dosage forms obtained on the basis of dry extract is small, despite the wide range of pharmacological activity. The aim of the study is to optimize the method of obtaining alcohol extract, with the possibility of including it in various dosage forms. Physico-chemical analysis: Confirmation of the alleged pharmacological activity by the method of molecular modeling. Materials and Methods: Ultrasonic extraction, spectrophotometry in the ultraviolet region. Pharmacological studies by modeling cerebral ischemia using simultaneous bilateral occlusion of the common carotid arteries. Changing the speed of cerebral blood flow by Dopplerography. Results and Discussion. Liquid extract of ginkgo bilobar leaves was obtained by ultrasonic extraction. The calculation of the electronic structure and quantum-chemical descriptors of ginkgolide B. was carried out. The assessment of specific pharmacological activity was carried out. Conclusion: The ultrasonic method of extraction of ginkgo biloba leaves was applied. The predicted biological activity of the obtained phytocomplex was confirmed by methods of molecular modeling and experimentally.

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Matuszkiewicz, Jan M. « Ground water as the main factor differentiating the natural vegetion in a landscape phytocomplex ("Grabowy" range in the Kampinos Forest Complex) ». Acta Societatis Botanicorum Poloniae 51, n^o 2 (2014) : 309–21. http://dx.doi.org/10.5586/asbp.1982.028.

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In the period 1973-1975 the depth of the ground water level and the moisture of the surface soil layer were investigated in various plant communities of the "Grabowy" range in the Kampinos Forest Complex (central Poland). The studies included a fragment of a landscape phytocomplex within which eight types of forest plant communities were distinguished. It was found that the plant communities change parallelly to the differences in the soil-water conditions (ground water level, physical properties and moisture of soils) in space.

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Vasarri, Marzia, Emanuela Barletta et Donatella Degl’Innocenti. « Posidonia oceanica (L.) Delile Extract Reduces Lipid Accumulation through Autophagy Activation in HepG2 Cells ». Pharmaceuticals 14, n^o 10 (24 septembre 2021) : 969. http://dx.doi.org/10.3390/ph14100969.

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Posidonia oceanica (L.) Delile is a marine plant traditionally used as an herbal medicine for various health disorders. P. oceanica leaf extract (POE) has been shown to be a phytocomplex with cell-safe bioactivities, including the ability to trigger autophagy. Autophagy is a key pathway to counteract non-alcoholic fatty liver disease (NAFLD) by controlling the breakdown of lipid droplets in the liver. The aim of this study was to explore the ability of POE to trigger autophagy and reduce lipid accumulation in human hepatoma (HepG2) cells and then verify the possible link between the effect of POE on lipid reduction and autophagy activation. Expression levels of autophagy markers were monitored by the Western blot technique in POE-treated HepG2 cells, whereas the extent of lipid accumulation in HepG2 cells was assessed by Oil red O staining. Chloroquine (CQ), an autophagy inhibitor, was used to study the relationship between POE-induced autophagy and intracellular lipid accumulation. POE was found to stimulate an autophagy flux over time in HepG2 cells by lowering the phosphorylation state of ribosomal protein S6, increasing Beclin-1 and LC3-II levels, and decreasing p62 levels. By blocking autophagy with CQ, the effect of POE on intracellular lipid accumulation was clearly reversed, suggesting that the POE phytocomplex may reduce lipid accumulation in HepG2 cells by activating the autophagic process. This work indicates that P. oceanica may be considered as a promising molecule supplier to discover new natural approaches for the management of NAFLD.

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Leonteva, N. V., I. D. Gerbekova, L. V. Borlakova et A. Y. Lyanguzov. « NEPHROPROTECTIVE PROPERTIES OF THE PHYTOCOMPLEX ON THE BASIS OF THE SMALL-LEAVED TANGENT ». Nephrology (Saint-Petersburg) 22, n^o 3 (12 mai 2018) : 65–71. http://dx.doi.org/10.24884/1561-6274-2018-22-3-65-71.

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Carradori, Simone, Francesco Cairone, Stefania Garzoli, Giancarlo Fabrizi, Antonia Iazzetti, Anna Maria Giusti, Luigi Menghini et al. « Phytocomplex Characterization and Biological Evaluation of Powdered Fruits and Leaves from Elaeagnus angustifolia ». Molecules 25, n^o 9 (26 avril 2020) : 2021. http://dx.doi.org/10.3390/molecules25092021.

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Fully ripe fruits and mature leaves of Elaeagnus angustifolia were harvested and analyzed by means of analytical and biological tests to better comprehend the chemical composition and therapeutic/nutraceutical potential of this plant. Fruits and leaves were dried and the obtained powders were analyzed to study their color character and (via headspace gas chromatography) describe the chemical profile. Subsequently, they were submitted to a chloroform–methanol extraction, to a hydroalcoholic extraction procedure assisted or not by microwaves, and to an extraction with supercritical CO2, assisted or not by ethanol as the co-solvent, to detect the polyphenolic and the volatile content. The resulting extracts were evaluated in terms of chlorophyll and carotenoid content, polyphenolic content, volatile fraction, total phenolic content, total flavonoid content, antioxidant activity, radical scavenging activity, and enzymatic inhibition activity. The results confirmed the correlation between the chemical composition and the high antioxidant potential of leaf extracts compared to the fruit extracts in terms of the phenolic and pigment content. A promising effect against tyrosinase emerged for all the extracts, suggesting a therapeutic/nutraceutical use for this plant. Conversely, the volatile content from both natural matrices was similar.

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Russo, Rossella, Maria Tiziana Corasaniti, Giacinto Bagetta et Luigi Antonio Morrone. « Exploitation of Cytotoxicity of Some Essential Oils for Translation in Cancer Therapy ». Evidence-Based Complementary and Alternative Medicine 2015 (2015) : 1–9. http://dx.doi.org/10.1155/2015/397821.

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Essential oils are complex mixtures of several components endowed with a wide range of biological activities, including antiseptic, anti-inflammatory, spasmolytic, sedative, analgesic, and anesthetic properties. A growing body of scientific reports has recently focused on the potential of essential oils as anticancer treatment in the attempt to overcome the development of multidrug resistance and important side effects associated with the antitumor drugs currently used. In this review we discuss the literature on the effects of essential oils in in vitroandin vivomodels of cancer, focusing on the studies performed with the whole phytocomplex rather than single constituents.

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Nanni, Valentina, Gabriele Di Marco, Gianni Sacchetti, Antonella Canini et Angelo Gismondi. « Oregano Phytocomplex Induces Programmed Cell Death in Melanoma Lines via Mitochondria and DNA Damage ». Foods 9, n^o 10 (17 octobre 2020) : 1486. http://dx.doi.org/10.3390/foods9101486.

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Plant secondary metabolites possess chemopreventive and antineoplastic properties, but the lack of information about their exact mechanism of action in mammalian cells hinders the translation of these compounds in suitable therapies. In light of this, firstly, Origanum vulgare L. hydroalcoholic extract was chemically characterized by spectrophotometric and chromatographic analyses; then, the molecular bases underlying its antitumor activity on B16-F10 and A375 melanoma cells were investigated. Oregano extract induced oxidative stress and inhibited melanogenesis and tumor cell proliferation, triggering programmed cell death pathways (both apoptosis and necroptosis) through mitochondria and DNA damage. By contrast, oregano extract was safe on healthy tissues, revealing no cytotoxicity and mutagenicity on C2C12 myoblasts, considered as non-tumor proliferating cell model system, and on Salmonella strains, by the Ames test. All these data provide scientific evidence about the potential application of this food plant as an anticancer agent in in vivo studies and clinical trials.

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Biagi, Marco. « The Importance of the Phytocomplex : The Inspiring and Illuminating Example of Cannabis sativa L. » Current Bioactive Compounds 15, n^o 2 (12 mars 2019) : 146. http://dx.doi.org/10.2174/157340721502190312102202.

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Gorbacheva, I. A., Ju A. Sycheva, I. V. Kyrdyumov, L. P. Egorova et O. V. Makhiaylova. « Correction of the functional condition of the bile excretory system in pathogenetic management of polymorbid patients with atherosclerosis ». Scientific Notes of the I. P. Pavlov St. Petersburg State Medical University 20, n^o 4 (30 décembre 2013) : 19–23. http://dx.doi.org/10.24884/1607-4181-2013-20-4-19-23.

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The aim of the search was development of some methods for improvement of effectiveness of treatment of polymorbid patients with atherosclerosis and disordered bile outflow. Complex phytotherapy (phytocomplex «Hepar») with its hepatoprotective and choleratic effects was prescribed for 33 patients with atherosclerosis and hepatobiliary dysfunction (in addition to dietotherapy and choleratics). Administration of the balanced phytotherapy resulted in significant reduction of the cholesterol level associated with the decrease of the C-reactive protein index in the blood. These changes were followed by decrease of the blood lipids and protein substrates oxidation - the factors meaning suppression of the degree of oxidative stress and of inflammation in the body.

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Миргород, В. С., Н. І. Філімонова, О. Г. Башура et С. Г. Бобро. « Study of the effect of dermatological phytogel on the ability of microorganisms to form a biofilm ». Farmatsevtychnyi zhurnal, n^o 5 (22 octobre 2021) : 68–76. http://dx.doi.org/10.32352/0367-3057.5.21.07.

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The development of many chronic infections, including skin diseases, is caused by bacteria growing in the form of biofilms. Bacterial biofilms provide beneficial survival mechanisms that determine virulence, disease pathogenesis, or resistance of the pathogen to antibiotics. As shown by a large number of studies, biofilms play an important role in the pathogenesis of dermatological diseases, including atopic dermatitis. The close relationship between the microbial biofilm that colonizes the skin surface and the negative consequences for human health makes the skin microbiome an object of therapeutic intervention in dermatological pathogenic processes. The work aims to study the effect of dermatological phytogel on the ability of microorganisms to form biofilms. The objects of research were samples of gel containing dry walnut leaf extract with the sum of tannins in terms of gallic acid and dry matter 30 mg/100 g of gel, dry nettle extract with the sum of hydroxycinnamic acids in terms of chlorogenic acid, and dry matter 20 mg/100 g of gel, dry thyme extract with the sum of flavonoids in terms of rutin and dry matter 35 mg/100 g of gel both monocomponent and combined. The study of the ability of individual plant components of phytogel samples N 1, N 2, N 3 and samples of combined phytogel N 4, N 5, and N 6 to influence biofilm formation have shown that the most pronounced decceleration of biofilms formation was registered in the gel sample with phytocomplex N 4 and was 19.7–20.7% to S. aureus, E. coli, P. aerugenosis and C. albicans respectively. The activity of the gel sample with phytocomplex N 4 was 1.3–1.4 times higher than that of monocomponent gel samples N 1, N 2, and N 3. When determining the ability of the test samples to destroy biofilms, it has been found that the gel sample with phytocomplex N 4 showed the greatest activity, which exceeded the specified properties of samples N 5 and N 6 by an average of 1.2 and 1.8 times. The activity of single-component gel samples N 1, N 2, and N 3 was lower in S. aureus, E. coli, P. aerugenosis and C. albicans biofilm destruction. The conducted studies prove the feasibility of further study of the combined gel with the phyto complex № 4 containing dry walnut leaf extract with the sum of tannins in terms of gallic acid and dry matter 30 mg/100 g of gel, dry nettle extract with the sum of hydroxycinnamic acids in terms of chlorogenic acid, and dry matter 20 mg/100 g of gel, dry thyme extract with the sum of flavonoids in terms of rutin and dry matter 35 mg/100 g of gel.

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Kudo, Risa, Katsuya Yuui et Shogo Kasuda. « Endothelium-Independent Relaxation of Vascular Smooth Muscle Induced by Persimmon-Derived Polyphenol Phytocomplex in Rats ». Nutrients 14, n^o 1 (26 décembre 2021) : 89. http://dx.doi.org/10.3390/nu14010089.

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The vasorelaxant effect of polyphenols is well known, and the mortality rate due to coronary artery disease is low in people who consume polyphenol-containing foods. We aimed to elucidate the mechanism by which polyphenols derived from persimmon juice (PJ) and persimmon leaves (PLs) induce vasorelaxation and suppress vasocontraction in the superior mesenteric arteries isolated from male Sprague Dawley rats. Vasocontraction was induced with 1 µM phenylephrine, and polyphenol-induced vasorelaxation was expressed as a percentage of the previous tone induced by phenylephrine. PJ powder (100 mg/L) induced higher levels of vasorelaxation (mean ± standard error of the mean, 88.6% ± 4.4%) than PLs powder (1 g/L; 72.0% ± 10.8%). Nitric oxide pathway inhibitors (NG-nitro-L-arginine methyl ester + carboxy-PTIO) did not affect persimmon-derived polyphenol-induced vasorelaxation, whereas potassium chloride, tetraethylammonium, and potassium-channel inhibitors did. Vasorelaxation was endothelium independent with both extracts. Phenylephrine-induced vasocontraction was suppressed by pretreatment with PJ and PLs powder, even when inositol triphosphate-mediated Ca2+ release and extracellular Ca2+ influx were inhibited. These results suggest that persimmon-derived polyphenol phytocomplex cause vasorelaxation and inhibit vasocontraction through hyperpolarization of smooth muscle cells. Persimmon-derived polyphenols may be able to prevent cardiovascular diseases caused by abnormal contraction of blood vessels.

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Donno, D., G. L. Beccaro, M. G. Mellano, A. K. Cerutti, V. Marconi et G. Bounous. « Botanicals inRibes nigrumbud-preparations : An analytical fingerprinting to evaluate the bioactive contribution to total phytocomplex ». Pharmaceutical Biology 51, n^o 10 (11 juillet 2013) : 1282–92. http://dx.doi.org/10.3109/13880209.2013.786101.

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Sadi, Sai-Suu S., M. I. Kalimullin et V. M. Poznnyakovskiy. « An innovative technology for natural raw materials processing and phytocomplex production of a functional purpose ». IOP Conference Series : Earth and Environmental Science 395 (27 novembre 2019) : 012089. http://dx.doi.org/10.1088/1755-1315/395/1/012089.

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Hasa, Dritan, Beatrice Perissutti, Stefano Dall’Acqua, Michele R. Chierotti, Roberto Gobetto, Iztok Grabnar, Cinzia Cepek et Dario Voinovich. « Rationale of using Vinca minor Linne dry extract phytocomplex as a vincamine’s oral bioavailability enhancer ». European Journal of Pharmaceutics and Biopharmaceutics 84, n^o 1 (mai 2013) : 138–44. http://dx.doi.org/10.1016/j.ejpb.2012.11.025.

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