Thèses sur le sujet « Physiology and psycology analyses »
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Kerwin, David G. « Force plate analyses of human jumping ». Thesis, Loughborough University, 1997. https://dspace.lboro.ac.uk/2134/7457.
Texte intégralCarneiro, Andrea Almeida. « Analyses of curcurbit P-protein promoters in transgenic plants ». Diss., The University of Arizona, 1998. http://hdl.handle.net/10150/298810.
Texte intégralMuhammad, Belal Abdul-Rahman. « Identification, characterisation and functional analyses of novel beta-catenin associated protein, FLYWCH1 ». Thesis, University of Nottingham, 2013. http://eprints.nottingham.ac.uk/14419/.
Texte intégralHo, Siu-yin Bryan, et 何兆賢. « Genetic analyses of the roles of Sox2 and Sox18 in mouse hair development and growth ». Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/206748.
Texte intégralpublished_or_final_version
Biochemistry
Doctoral
Doctor of Philosophy
Ward, Charlotte. « Application of metabolic flux and transcript analyses to understanding the physiology of engineered Geobacillus thermoglucosidasius ». Thesis, Imperial College London, 2014. http://hdl.handle.net/10044/1/25514.
Texte intégralVarberg, Kaela Margaret. « Kinetic Vasculogenic Analyses of Endothelial Colony Forming Cells Exposed to Intrauterine Diabetes ». Thesis, Indiana University - Purdue University Indianapolis, 2017. http://pqdtopen.proquest.com/#viewpdf?dispub=10601464.
Texte intégralVasculogenesis is a complex process by which endothelial stem and progenitor cells undergo de novo vessel formation. Quantitative assessment of vasculogenesis is a central readout of endothelial progenitor cell functionality. However, current assays lack kinetic measurements. To address this issue, new approaches were developed to quantitatively assess in vitro endothelial colony forming cell (ECFC) network formation in real time. Eight parameters of network structure were quantified using novel Kinetic Analysis of Vasculogenesis (KAV) software. KAV assessment of structure complexity identified two phases of network formation. This observation guided the development of additional vasculogenic readouts, including a tissue cytometry approach to quantify the frequency and localization of dividing ECFCs within cell networks. Additionally, FIJI TrackMate was used to quantify ECFC displacement and speed at the single cell level during network formation. These novel approaches were then applied to determine how intrauterine exposure to maternal type 2 diabetes mellitus (T2DM) impairs fetal ECFC vasculogenesis, and whether increased Transgelin 1 (TAGLN) expression in ECFCs from pregnancies complicated by gestational diabetes (GDM) was sufficient to impair vasculogenesis. Fetal ECFCs exposed to maternal T2DM formed fewer initial network structures, which were not stable over time. Correlation analyses identified that ECFC samples with greater division in branches formed fewer closed network structures and that reductions in ECFC movement decreased structural connectivity. To identify specific cellular mechanisms and signaling pathways altered in ECFCs following intrauterine GDM exposure, these new techniques were also applied in TAGLN expression studies. Similarly, ECFCs from GDM pregnancies and ECFCs overexpressing TAGLN exhibited impaired vasculogenesis and decreased migration. Both ECFCs from GDM pregnancies as well as ECFCs over-expressing TAGLN exhibited increased phosphorylation of myosin light chain. Reduction of myosin light chain phosphorylation via Rho kinase inhibition increased ECFC migration; therefore, increased TAGLN was sufficient to impair ECFC vasculogenic function. Overall, identification of these novel phenotypes provides evidence for the molecular mechanisms contributing to aberrant ECFC vasculogenesis. Determining how intrauterine exposure to maternal T2DM and GDM alters fetal ECFC function will enable greater understanding of the chronic vascular pathologies observed in children from pregnancies complicated by diabetes mellitus.
Hightower, Mary H. (Mary Helen). « Electrophysiological and Morphological Analyses of Mouse Spinal Cord Mini-Cultures Grown on Multimicroelectrode Plates ». Thesis, University of North Texas, 1988. https://digital.library.unt.edu/ark:/67531/metadc798142/.
Texte intégralDeLong, Caroline M. « Object-centered representations in echolocating dolphins evidence from acoustic analyses of object echoes and a human listening study / ». Thesis, University of Hawaii at Manoa, 2003. http://proquest.umi.com/pqdweb?index=0&did=765084621&SrchMode=1&sid=7&Fmt=2&VInst=PROD&VType=PQD&RQT=309&VName=PQD&TS=1233101570&clientId=23440.
Texte intégralScholz, Nicole [Verfasser], Tobias [Gutachter] Langenhan et Christian [Gutachter] Stigloher. « Genetic analyses of sensory and motoneuron physiology in Drosophila melanogaster / Nicole Scholz ; Gutachter : Tobias Langenhan, Christian Stigloher ». Würzburg : Universität Würzburg, 2015. http://d-nb.info/1148279695/34.
Texte intégralKwong, Wai-hang, et 鄺偉恒. « Functional analyses on TGF{221}/BMP signaling and type IIA procollagenin inner ear development ». Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B43815601.
Texte intégralHenriques, Paula Suarez. « Gene expression analyses on adipose tissue of Nellore peripubertal heifers reveal genes that have an impact on reproductive physiology ». Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/11/11139/tde-09082017-113513/.
Texte intégralO desenvolvimento púbere é o resultado da interação de genes que produzem sinais moleculares regulando os mecanismos fisiológicos. A compreensão das mudanças genéticas que permeiam o período peripuberal em novilhas Nelore (Bos indicus) poderia desvendar o porquê das diferenças em idade a puberdade, pois elas atingem a maturidade sexual mais tarde que o gado europeu (Bos taurus). O tecido adiposo regula o metabolismo de energia e é um órgão endócrino que tem participação ativa em processos reprodutivos. O presente estudo teve como objetivo entender as funções do tecido adiposo na época peripubertal em novilhas Nelore. Nossa estratégia foi procurar diferenças em expressão gênica entre animais pré-púberes e púberes. Nós quantificamos a expressão gênica no tecido adiposo de novilhas Nelores precoces ou tardias. A pesquisa foi feita em 30 novilhas Nelore, monitoradas semanalmente a partir do momento em que atingiram 230 kg de peso até a manifestação da puberdade por exame de ultrassom ginecológico. O momento da puberdade foi definido pela presença de corpo lúteo no ovário e concentração sanguínea de progesterona maior que > 1 ng/ml. O tecido adiposo foi coletado por biópsia subcutânea; a primeira biópsia foi feita quando as novilhas alcançaram 230 quilos de peso e subsequentemente uma vez por mês ate que elas entrassem em puberdade. As biópsias foram coletadas de cada novilha que atingiu a puberdade e de sua meia-irmã que não tinha atingido a puberdade. Nós analisamos amostras de seis novilhas púberes precoces e de seis novilhas púberes tardias em dois estágios diferentes: no momento da ovulação e aproximadamente 50 dias antes da ovulação. O RNA foi extraído do tecido das biopsias e a expressão genica quantificada através de sequenciamento de RNA. Encontramos nove genes diferencialmente expressos em novilhas púberes que foram previamente relacionados com características e/ou processos reprodutivos de mamíferos em outros estudos. Esses genes foram APOD, CYP17A1, DNMT3B, AKR1C4, TENM1/ODZ3, HPSE, SMPD3, FAM134B e CYP26B1, já encontrados expressos em adipócitos, hipotálamo, ovários e útero, comprovando conhecimento prévio da conexão existente entre metabolismo de energia, órgãos reprodutivos e influencia neural. Ao medir as mudanças genéticas e correlacioná-las com mecanismos fisiológicos conhecidos em sistema nervoso e órgãos reprodutivos durante a puberdade, nós conseguimos identificar genes expressos em adiposo que são relacionados a modificações no organismo como um todo. Sendo assim, o tecido adiposo pode ser considerado um instrumento para indicar o que está acontecendo durante os processos reprodutivos. .Os resultados apresentados aqui podem ajudar na melhor compreensão de mudanças genéticas durante o período peripuberal.
Savage, Christina R. « FUNCTIONAL ANALYSES OF THE DNA- AND RNA-BINDING PROTEIN SPOVG IN BORRELIA BURGDORFERI ». UKnowledge, 2019. https://uknowledge.uky.edu/microbio_etds/21.
Texte intégralMestriner, Cleber Baessa. « Diversidade e hierarquia : a psicologia de Nietzsche enquanto tipologia hier?rquica ». Universidade Estadual do Oeste do Parana, 2007. http://tede.unioeste.br:8080/tede/handle/tede/2076.
Texte intégralThis dissertation analyses the psychology concept on Nietzsche?s philosophy and its relation to the typology and hierarchy. First of all, it was verified that the meaning of the Nietzsche psychological research is based on the concept of power will which is considered by the German philosopher as an interpretation of the world and not a description. The power will has as mean characteristic to affirm the effectiveness as a come of strengths in fight for more power and depose of truth the metaphysics oppositions. These strengths, or impulses, are understood as power quanta that differ each other and they relate with all of other quanta in order to intensify. Therefore, the power intensity is what differ the strengths. This way, we understand the fight of the strengths as a domination process, which produce impulses complex or hierarchies. The development of these hierarchical configurations of strengths comes from the dynamic establishment of commander and commanded, that is, from dominion relations that are expressed in ways of life, human types. Types, however, are not understood as essential manifestations of a being, but as strength relation?s symptoms and their hierarchical configurations. These symptoms are the object of the psychology proposed by Nietzsche, and not the human soul or conscience. The human types are analyzed by the German philosopher through two great and focused perspectives, one of ascendancy (powerful and heavily hierarchizated impulses) and another of life?s decadence (weak and anarchic impulses). From this general aspect of Nietzsche typology, is verified the importance of the types, considering that for the appearance of a type is necessary the existence of its differentiated, because there is a relation of domination between them. Thus, the job of the nietzschean psychologist is, with grounding in the interpretation of the world as power will, to evaluate the various ways of life and make them hierarchical. Therefore, Nietzsche psychological evaluation corresponds to differ and make hierarchical the humans types, understood as symptoms of strength relations, in affirmation, growth, strength and overcome ways of life and negation, decline, weakness and conservation ways of life. This way, it is concluded that Nietzsche psychology is an evaluation exercise of various human kinds, understood as morphology and theory of the power will improvement
Esta disserta??o analisa o conceito de psicologia na filosofia de Nietzsche e sua rela??o com a tipologia e a hierarquia. Inicialmente, verificamos que o sentido da pesquisa psicol?gica de Nietzsche ? alicer?ado sobre o conceito de vontade de pot?ncia, que ? considerado pelo fil?sofo alem?o uma interpreta??o e n?o uma descri??o do mundo. A vontade de pot?ncia tem como caracter?stica principal afirmar a efetividade enquanto um devir de for?as em luta por mais pot?ncia e destituir de verdade as oposi??es metaf?sicas. Estas for?as, ou impulsos, s?o compreendidas enquanto quanta de pot?ncia que se diferenciam e se relacionam com todos os outros quanta de forma a se intensificar. O que diferencia as for?as, portanto, ? a intensidade de pot?ncia. Assim, entendemos a luta das for?as enquanto um processo de domina??o, o que produz conjuntos de impulsos ou hierarquias. O desenvolvimento destas configura??es hier?rquicas de for?as se d? pelo estabelecimento din?mico de mandantes e mandados, ou seja, por rela??es de dom?nio, que se expressam em modos de vida, tipos humanos. Os tipos, entretanto, n?o s?o entendidos enquanto manifesta??es essenciais de um ser, mas sim enquanto sintomas das rela??es das for?as e suas conseq?entes configura??es hier?rquicas. Esses sintomas s?o o objeto da psicologia proposta por Nietzsche, e n?o a alma ou a consci?ncia humana. Os tipos humanos s?o analisados pelo fil?sofo alem?o mediante duas grandes e centrais perspectivas, uma de ascend?ncia (impulsos potentes e fortemente hierarquizados) e outra de decad?ncia da vida (impulsos fracos e an?rquicos). A partir deste aspecto geral da tipologia de Nietzsche, verificamos a imprescindibilidade dos tipos, sendo que para o surgimento de um tipo ? necess?ria a exist?ncia do seu diferenciado, pois h? rela??o de domina??o entre eles. Assim, a fun??o do psic?logo nietzschiano ?, com base na interpreta??o do mundo enquanto vontade de pot?ncia, avaliar os diversos modos de vida e hierarquiz?-los. A avalia??o psicol?gica de Nietzsche, portanto, corresponde a diferenciar e hierarquizar os tipos humanos, compreendidos enquanto sintomas das rela??es de for?as, em modos de vida de afirma??o, crescimento, for?a, supera??o, e em modos de vida de nega??o, de decl?nio, fraqueza e conserva??o. Conclu?mos, desse modo, que a psicologia de Nietzsche ? um exerc?cio de avalia??o dos diversos tipos humanos, entendida enquanto morfologia e teoria do desenvolvimento da vontade de pot?ncia
Mayberry, Jason Robert. « Through the eyes of bat flies| Behavioral, phylogenetic, and histological analyses of compound eye reduction in bat flies (Streblidae) provide evidence for positive selection ». Thesis, State University of New York at Buffalo, 2015. http://pqdtopen.proquest.com/#viewpdf?dispub=3714642.
Texte intégralIt is often presumed that evolutionary reduction is tantamount to deconstruction, or even destruction, because relaxed selective forces have been insufficient to maintain the organ in its original state. However, studies on reduction are often limited by a lack of diversity, both of related species exhibiting reduction and of the reduced form itself. There have also been very few studies on the reduction of compound eyes, despite the fact that their near ubiquity among arthropods alone makes them perhaps the most common type of eye. Bat flies (Streblidae and Nycteribiidae) are a group of dipterans that exhibit variable degrees of compound eye reduction, and therefore provide the opportunity to study reduction of this organ in a phylogenetic context. The first chapter of this work reports on behavioral experiments demonstrating that the eyes of one bat fly species, Trichobius frequens, are functional, and that they neither exhibit phototaxis typical of other dipteran species, nor move toward a light source. The second chapter uses molecular phylogenetics to identify a correlation between eye and wing morphology. The results also suggest that secondary to their eye reduction, bat flies (at least in the case of New World specie, including Trichobius spp.) have secondarily experienced a shift in the structure of their facets that is convergent with other insects whose eyes have been selected for increased sensitivity. In the final chapter, histological and optical analyses of T. frequens eyes are used to reveal significant structural changes to the microstructure of its ommatidia that increase sensitivity at the expense of acuity. Many of these changes are also convergent with similar adaptations that have been demonstrated to increase sensitivity in organisms that function in reduced light environments. The results of these analyses suggest that reduction in T. frequens eyes may have been part of an active remodeling process resulting from a shift in the relative importance of sensitivity and acuity. As this is a process of reduction not generally considered, the findings here turn our attention to alternative hypotheses that should be considered when studying evolutionary reduction of any organ.
Gentles, Jeremy A. « Analyses of Volume Load and Training Intensity in Competitive Weightlifters Across 5 Months of Training ». Digital Commons @ East Tennessee State University, 2012. https://dc.etsu.edu/etsu-works/3982.
Texte intégralLee, Sengyong. « Analyses of mutants in the 33 kDa manganese stabilizing protein of photosystem II and construction of a deletion mutant in synechococcus PCC 7942 ». Virtual Press, 1993. http://liblink.bsu.edu/uhtbin/catkey/865930.
Texte intégralDepartment of Biology
Fellows, Christopher R. « Analyses of articular cartilage-derived stem cells : identification of cellular markers for stem cells within the healthy and osteoarthritic knee articular cartilage ». Thesis, Cardiff University, 2014. http://orca.cf.ac.uk/70446/.
Texte intégralSchaber, Jörg. « Phenology in Germany in the 20th century : methods, analyses and models ». Phd thesis, Universität Potsdam, 2002. http://opus.kobv.de/ubp/volltexte/2005/50/.
Texte intégralDie Analyse der Pflanzenphänologie in Süddeutschland im 20. Jahrhundert zeigte:
- Die starke Verfrühung der Frühjahrsphasen in dem Jahrzehnt vor 1999 war kein singuläres Ereignis im 20. Jahrhundert. Schon in früheren Dekaden gab es ähnliche Trends. Es konnten Perioden mit unterschiedlichem Trendverhalten identifiziert werden.
- Es gab deutliche Unterschiede in den Trends von frühen und späten Frühjahrsphasen. Die frühen Frühjahrsphasen haben sich stetig verfrüht, mit deutlicher Verfrühung zwischen 1931 und 1948, moderater Verfrühung zwischen 1948 und 1984 und starker Verfrühung zwischen 1984 und 1999. Die späten Frühjahrsphasen hingegen, wechselten ihr Trendverhalten in diesen Perioden von einer Verfrühung zu einer deutlichen Verspätung wieder zu einer starken Verfrühung.
Dieser Unterschied in der Trendentwicklung zwischen frühen und späten Frühjahrsphasen konnte auch für ganz Deutschland in den Perioden 1951 bis 1984 und 1984 bis 1999 beobachtet werden.
Der bestimmende Einfluss der Temperatur auf die Frühjahrsphasen und ihr modifizierender Einfluss auf die Herbstphasen konnte bestätigt werden. Es zeigt sich jedoch, dass
- die Phänologie bestimmende Funktionen der Temperatur nicht mit einem globalen jährlichen CO2 Signal korreliert waren, welches als Index für die globale Erwärmung verwendet wurde
- ein Index für grossräumige regionale Zirkulationsmuster (NAO-Index) nur zu einem kleinen Teil die beobachtete phänologischen Variabilität erklären konnte.
Das beobachtete unterschiedliche Trendverhalten zwischen frühen und späten Frühjahrsphasen konnte auf die unterschiedliche Entwicklung von März- und Apriltemperaturen zurückgeführt werden. Während sich die Märztemperaturen im Laufe des 20. Jahrhunderts mit einer zunehmenden Variabilität in den letzten 50 Jahren stetig erhöht haben, haben sich die Apriltemperaturen zwischen dem Ende der 1940er und Mitte der 1980er merklich abgekühlt und dann wieder deutlich erwärmt.
Es wurde geschlussfolgert, dass die Verfrühungen in der Frühjahrsphänologie in den letzten Dekaden Teile multi-dekadischer Fluktuationen sind, welche sich nach Spezies und relevanter saisonaler Temperatur unterscheiden. Aufgrund dieser Fluktuationen konnte kein Zusammenhang mit einem globalen Erwärmungsignal gefunden werden.
Im Durchschnitt haben sich alle betrachteten Frühjahrsphasen zwischen 1951 und 1999 in Naturräumen in Deutschland zwischen 5 und 20 Tagen verfrüht. Ein starker Unterschied in der Verfrühung zwischen frühen und späten Frühjahrsphasen liegt an deren erwähntem unterschiedlichen Verhalten. Die Blattverfärbung hat sich zwischen 1951 und 1999 für alle Spezies verspätet, aber nach 1984 im Durchschnitt verfrüht. Die VP hat sich in Deutschland zwischen 1951 und 1999 um ca. 10 Tage verlängert.
Es ist hauptsächlich die Änderung in den Frühjahrphasen, die zu einer Änderung in der potentiell absorbierten Strahlung (PAS) führt. Darüber hinaus sind es die späten Frühjahrsphasen, die pro Tag Verfrühung stärker profitieren, da die zusätzlichen Tage länger undwärmer sind als dies für die frühen Phasen der Fall ist. Um die relative Änderung in PAS im Vergleich der Spezies abzuschätzen, müssen allerdings auch die Veränderungen in den Herbstphasen berücksichtigt werden.
Der deutliche Unterschied zwischen frühen und späten Frühjahrsphasen konnte durch die Anwendung einer neuen Methode zur Konstruktion von Zeitreihen herausgearbeitet werden. Der neue methodische Ansatz erlaubte die Ableitung verlässlicher 100-jähriger Zeitreihen und die Konstruktion von lokalen kombinierten Zeitreihen, welche die Datenverfügbarkeit für die Modellentwicklung erhöhten.
Ausser analysierten Protokollierungsfehlern wurden mikroklimatische, genetische und Beobachtereinflüsse als Quellen von Unsicherheit in phänologischen Daten identifiziert. Phänologischen Beobachtungen eines Ortes können schätzungsweise 24 Tage um das parametrische Mittel schwanken.Dies unterstützt die 30-Tage Regel für die Detektion von Ausreissern.
Neue Phänologiemodelle, die den Blattaustrieb aus täglichen Temperaturreihen simulieren, wurden entwickelt. Diese Modelle basieren auf einfachen Interaktionen zwischen aktivierenden und hemmenden Substanzen, welche die Entwicklungsstadien einer Pflanze bestimmen. Im Allgemeinen konnten die neuen Modelle die Beobachtungsdaten besser simulieren als die klassischen Modelle.
Weitere Hauptresultate waren:
- Der Bias der klassischen Modelle, d.h. Überschätzung von frühen und Unterschätzung von späten Beobachtungen, konnte reduziert, aber nicht vollständig eliminiert werden.
- Die besten Modellvarianten für verschiedene Spezies wiesen darauf hin, dass für die späten Frühjahrsphasen die Tageslänge eine wichtigere Rolle spielt als für die frühen Phasen.
- Die Vernalisation spielte gegenüber den Temperaturen kurz vor dem Blattaustrieb nur eine untergeordnete Rolle.
The length of the vegetation period (VP) plays a central role for the interannual variation of carbon fixation of terrestrial ecosystems. Observational data analysis has indicated that the length of the VP has increased in the last decades in the northern latitudes mainly due to an advancement of bud burst (BB). This phenomenon has been widely discussed in the context of Global Warming because phenology is correlated to temperatures.
Analyzing the patterns of spring phenology over the last century in Southern Germany provided two main findings:
- The strong advancement of spring phases especially in the decade before 1999 is not a singular event in the course of the 20th century. Similar trends were also observed in earlier decades. Distinct periods of varying trend behavior for important spring phases could be distinguished.
- Marked differences in trend behavior between the early and late spring phases were detected. Early spring phases changed as regards the magnitude of their negative trends from strong negative trends between 1931 and 1948 to moderate negative trends between 1948 and 1984 and back to strong negative trends between 1984 and 1999. Late spring phases showed a different behavior. Negative trends between 1931 and 1948 are followed by marked positive trends between 1948 and 1984 and then strong negative trends between 1984 and 1999.
This marked difference in trend development between early and late spring phases was also found all over Germany for the two periods 1951 to 1984 and 1984 to 1999.
The dominating influence of temperature on spring phenology and its modifying effect on autumn phenology was confirmed in this thesis. However,
- temperature functions determining spring phenology were not significantly correlated with a global annual CO2 signal which was taken as a proxy for a Global Warming pattern.
- an index for large scale regional circulation patterns (NAO index) could only to a small part explain the observed phenological variability in spring.
The observed different trend behavior of early and late spring phases is explained by the differing behavior of mean March and April temperatures. Mean March temperatures have increased on average over the 20th century accompanied by an increasing variation in the last 50 years. April temperatures, however, decreased between the end of the 1940s and the mid-1980s, followed by a marked warming after the mid-1980s.
It can be concluded that the advancement of spring phenology in recent decades are part of multi-decadal fluctuations over the 20th century that vary with the species and the relevant seasonal temperatures. Because of these fluctuations a correlation with an observed Global Warming signal could not be found.
On average all investigated spring phases advanced between 5 and 20 days between 1951 and 1999 for all Natural Regions in Germany. A marked difference be! tween late and early spring phases is due to the above mentioned differing behavior before and after the mid-1980s. Leaf coloring (LC) was delayed between 1951 and 1984 for all tree species. However, after 1984 LC was advanced. Length of the VP increased between 1951 and 1999 for all considered tree species by an average of ten days throughout Germany.
It is predominately the change in spring phases which contributes to a change in the potentially absorbed radiation. Additionally, it is the late spring species that are relatively more favored by an advanced BB because they can additionally exploit longer days and higher temperatures per day advancement. To assess the relative change in potentially absorbed radiation among species, changes in both spring and autumn phenology have to be considered as well as where these changes are located in the year.
For the detection of the marked difference between early and late spring phenology a new time series construction method was developed. This method allowed the derivation of reliable time series that spanned over 100 years and the construction of locally combined time series increasing the available data for model development.
Apart from analyzed protocolling errors, microclimatic site influences, genetic variation and the observers were identified as sources of uncertainty of phenological observational data. It was concluded that 99% of all phenological observations at a certain site will vary within approximately 24 days around the parametric mean. This supports to the proposed 30-day rule to detect outliers.
New phenology models that predict local BB from daily temperature time series were developed. These models were based on simple interactions between inhibitory and promotory agents that are assumed to control the developmental status of a plant. Apart from the fact that, in general, the new models fitted and predicted the observations better than classical models, the main modeling results were:
- The bias of the classical models, i.e. overestimation of early observations and underestimation of late observations, could be reduced but not completely removed.
- The different favored model structures for each species indicated that for the late spring phases photoperiod played a more dominant role than for early spring phases.
- Chilling only plays a subordinate role for spring BB compared to temperatures directly preceding BB.
Vijayalakshmi, Kolluru. « Physiological and genetic analyses of post-anthesis heat tolerance in winter wheat (Triticum aestivum L.) ». Diss., Manhattan, Kan. : Kansas State University, 2007. http://hdl.handle.net/2097/300.
Texte intégralBartsch, Adam Jesse. « Biomechanical Engineering Analyses of Head and Spine Impact Injury Risk via Experimentation and Computational Simulation ». Case Western Reserve University School of Graduate Studies / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=case1291318455.
Texte intégralRoscoe, Benjamin P. « Analyses of All Possible Point Mutations within a Protein Reveals Relationships between Function and Experimental Fitness : A Dissertation ». eScholarship@UMMS, 2014. https://escholarship.umassmed.edu/gsbs_diss/716.
Texte intégralRoscoe, Benjamin P. « Analyses of All Possible Point Mutations within a Protein Reveals Relationships between Function and Experimental Fitness : A Dissertation ». eScholarship@UMMS, 2003. http://escholarship.umassmed.edu/gsbs_diss/716.
Texte intégralFlores, Nicolas. « Influence des propriétés mécaniques des chaussures sur la performance en course à pied d'endurance : analyses à court terme et lors d'une course à pied de durée prolongée ». Thesis, Aix-Marseille, 2019. http://www.theses.fr/2019AIXM0222.
Texte intégralWhile physiological benefits of baseline running racing shoes are shown in the scientific literature, the specific and controlled effects of some shoe mechanical features remain not well known. The main purpose of this work was to study the effects of the midsole energy return and the shoe longitudinal bending stiffness on the physiological and biomechanical performance during endurance running. In both short-term and prolonged running duration, the metabolic energetic cost (criteria used to evaluate the endurance running performance) was not significantly altered by the tested mechanical features in average over the group of participants. The main finding was that the shoe mechanical features induced different effects on the metabolic energetic cost depending on the participants. Taking into account the participant-specific responses (in both short-term and during a prolonged running duration) enabled to highlight combinations of biomechanical responses and intrinsic participant characteristics explaining the variations of the metabolic energetic cost as a function of shoe mechanical features. A novel strategy has been highlighted in participants benefiting from the shoe longitudinal bending stiffness resulting in descendant redistribution of the muscular coordination from the hip and knee joints to the ankle joint with the running duration. This work showed the importance of considering a footwear design offer suitable to groups of runners with similar biomechanical responses and/or intrinsic characteristics
INNOCENTI, GIOVANNI, et F. Schena. « From biology to training : basis and mechanisms of peak-performance in gymnastics and impact with other sports ». Doctoral thesis, 2015. http://hdl.handle.net/2158/1003945.
Texte intégralScholz, Nicole. « Genetic analyses of sensory and motoneuron physiology in Drosophila melanogaster ». Doctoral thesis, 2017. https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-123249.
Texte intégralIn dieser These wurden zwei grundlegende biologische Aspekte mittels Drosophila melanogaster untersucht, weshalb diese in zwei Teile gegliedert ist. TeiL I: Die Interaktion von Bruchpilot und Complexin vermittelt die Anbindung von synaptischen Vesikeln an die Zytomatrix der aktiven Zone Oft findet man an aktiven Zonen (AZ) von Präsynapsen elektronendichte Matrices, welche meist in physischem Kontakt mit synaptischen Vesikeln (SV) stehen. Dieser als „SV Tethering“ bezeichnete Prozess dient der Anreicherung SV in der unmittelbaren Nähe ihrer Freisetzungszonen, noch bevor diese mit dem SNARE Komplex interagieren, um mit der präsynapti-schen Plasmamembran zu fusionieren (Hallermann und Silver, 2013). In der Taufliege Drosophila melanogaster bildet das AZ Protein Bruchpilot (BRP) Protrusionen, um welche SV akkumulieren (Kittel et al., 2006b; Wagh et al., 2006; Fouquet et al., 2009). Interessan-terweise resultiert bereits eine minimale Verkürzung von BRP (1% der Gesamtlänge) am C-terminalen Ende in einem schwerwiegenden Anbindedefekt von SV, der mit einem Funkti-onsverlust dieser Synapsen einhergeht (brpnude; Hallermann et al., 2010b). Entsprechend diesem Vorbefund resultierte die gewebespezifische Überexpression eines C-terminalen BRP Fragments - mBRPC-tip (entspricht dem fehlenden Fragment der brpnude Mu-tante; m = mobil) - sowohl in Verhaltens- als auch funktionellen Analysen in einer Phänoko-pie der brpnude Mutante. Dies deutet daraufhin, dass mBRPC-tip vermeintliche vesikuläre Interaktionspartner blockiert und so die Anreicherung von SV an motoneuronalen AZ verhindert, was ähnlich wie in brpnude Mutanten zu einem funktionellen Tethering-Defekt führt. Die molekulare Identität eines BRP Partners zur Anreicherung von SV an der Zytomatrix der AZ wurde bisher nicht beschrieben. Weiterhin zeigt diese Arbeit, dass membrangebundene C-terminale BRP Anteile genügen, um SV an Positionen außerhalb von AZ zu binden. Basierend auf diesem Befund wurde ein gene-tischer in vivo Screen zur Identifikation von BRP Interaktoren entwickelt. Dieser Screen identifizierte Complexin (CPX), ein Protein, dessen hemmende beziehungsweise fördernde Wirkung auf die spontane und reizinduzierte Vesikelfusion bekannt ist (Huntwork und Littleton, 2007; Cho et al., 2010; Martin et al., 2011). CPX wurde bisher nicht mit einer Funktion ober-halb von Vesikelpriming und -fusion in Verbindung gebracht. Diese Studie dokumentiert strukturelle und funktionelle Hinweise, die darauf hindeuten, dass CPX mit BRP interagiert, um Vesikelakkumulation an AZ zu fördern und dadurch synaptischer Kurzzeit-Depression entgegen zu wirken. Teil II: Adhäsions-GPCR Latrophilin/CIRL moduliert die Wahrnehmung mechanischer Reize Der Kalzium-unabhängige Rezeptor für α-Latrotoxin (CIRL), oder Latrophilin, ist ein prototypischer Rezeptor der Adhäsions G-Protein gekoppelten Klasse (aGPCR). Identifiziert wurde Latrophilin ursprünglich aufgrund seiner Fähigkeit die α-Komponente von Latrotoxin (α-LTX) zu binden (Davletov et al., 1996; Krasnoperov et al., 1996), welches seine Wirkung am peripheren Nervensystem entfaltet und dort übermäßige Transmitterausschüttung an neuronalen Endigungen induziert (Scheer et al., 1984; Umbach et al., 1998; Orlova et al., 2000). Basierend auf diesem Effekt wurde Latrophilin eine Rolle bei der synaptischen Transmission zugesprochen. Später wurden Latrophiline mit weiteren biologischen Prozessen in Zusammenhang gebracht, darunter Gewebepolarität (Langenhan et al., 2009), Fertilität (Prömel et al., 2012) und Synaptogenese (Silva et al., 2011). Allerdings blieb sowohl die subzelluläre Lokalisation als auch die Identität endogener Liganden, zwei Schlüsselaspekte im Verständnis der in vivo Funktion von Latrophilinen bisher rätselhaft. Drosophila besitzt lediglich ein latrophilin Homolog, dCirl, dessen Funktion bisher nicht untersucht wurde. Diese Arbeit zeigt, dass dCirl in weiten Teilen des larvalen Nervensystems von Drosophila exprimiert ist. dCirl knock-out Mutanten sind lebensfähig und weisen keine Störungen in der Entwicklung und neuronalen Differenzierung auf. Allerdings schien dCirl Einfluss auf die Ausdehnung des postsynaptischen subsynaptischen Retikulums (SSR) zu nehmen, was mit einer erhöhten Menge an Discs-large (DLG) assoziiert war. Die morphologischen und funktionellen Eigenschaften präsynaptischer Motoneurone der Fliegenlarve hingegen, waren durch den Verlust von dCirl funktionell weitestgehend unbeeinträchtigt. Vielmehr ist dCirl notwendig für die Wahrnehmung mechanischer Reize (akustische-, taktile und propriozeptive) durch spezialisierte Vorrichtungen - Chordotonalorgane (Eberl, 1999). Die Befunde deuten daraufhin, dass dCirl die Sensitivität der Chordotonalneurone gegenüber mechanischen Reizen moduliert und dadurch das Input-Output Verhältnis einstellt. Adaptation der molekularen Mechanotransduktionsmaschinerie durch dCirl könnte die molekulare Grundlage für diesen Prozess darstellen, eine Hypothese die durch genetische Interaktionsanalysen gestützt wird. Schlussfolglich enthüllen die experimentellen Befunde dieser These eine unerwartete Funktion von Latrophilin/dCirl bei der Mechanoperzeption und implizieren eine generelle modula-torische Rolle für aGPCR bei der Wahrnehmung mechanischer Reize
Lasswell, Jamie Elizabeth. « Genetic analyses of auxin metabolism and of the transition to flowering in the model plant Arabidopsis thaliana ». Thesis, 2000. http://hdl.handle.net/1911/19525.
Texte intégralJackson, Stephen Mark. « Diversification of the bovine primary immunoglobulin heavy chain repertoire : Ontological and hypermutational analyses in fetal and neonatal animals ». 2002. https://scholarworks.umass.edu/dissertations/AAI3102816.
Texte intégralPethybridge, Heidi Rebecca. « Ecology and physiology of deepwater chondrichthyans off southeast Australia : mercury, stable isotope and lipid analysis = l'ecologie et la physiologie des chondrichthiens des profondeurs du sud-est de l'Australie : les analyses du mercure, des lipides et des isotope de carbone et d'azote ». Thesis, 2010. https://eprints.utas.edu.au/21195/1/whole_PethybridgeHeidiRebecca2010_thesis.pdf.
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