Littérature scientifique sur le sujet « Phosphatidylinositol phosphate analogues »

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Articles de revues sur le sujet "Phosphatidylinositol phosphate analogues"

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Gregory, Mark, Meng-Xin Yin, Malcolm J. McConville, et al. "Synthesis of Highly Water-Soluble Adamantyl Phosphoinositide Derivatives." Australian Journal of Chemistry 68, no. 4 (2015): 543. http://dx.doi.org/10.1071/ch14543.

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Phosphatidylinositol phosphates are key regulators of cell signalling pathways and membrane trafficking in eukaryotic cells, and there is a need for new chemical probes to further understand how they interact with lipid-binding proteins. Here, the synthesis of phosphatidylinositol phosphate analogues containing adamantyl carboxylic ester groups, in place of the natural lipid side chains, is described. These derivatives are considerably more soluble in water than analogues containing other lipid side chains and do not form large aggregates such as liposomes or micelles. These adamantyl analogue
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Ibrahim, Muktar Musa, Adamu Uzairu, Muhammad Tukur Ibrahim, and Abdullahi Bello Umar. "Modelling PIP4K2A inhibitory activity of 1,7-naphthyridine analogues using machine learning and molecular docking studies." RSC Advances 13, no. 6 (2023): 3402–15. http://dx.doi.org/10.1039/d2ra07382j.

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Boronenkov, Igor V., Joost C. Loijens, Masato Umeda, and Richard A. Anderson. "Phosphoinositide Signaling Pathways in Nuclei Are Associated with Nuclear Speckles Containing Pre-mRNA Processing Factors." Molecular Biology of the Cell 9, no. 12 (1998): 3547–60. http://dx.doi.org/10.1091/mbc.9.12.3547.

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Phosphoinositide signal transduction pathways in nuclei use enzymes that are indistinguishable from their cytosolic analogues. We demonstrate that distinct phosphatidylinositol phosphate kinases (PIPKs), the type I and type II isoforms, are concentrated in nuclei of mammalian cells. The cytosolic and nuclear PIPKs display comparable activities toward the substrates phosphatidylinositol 4-phosphate and phosphatidylinositol 3-phosphate. Indirect immunofluorescence revealed that these kinases were associated with distinct subnuclear domains, identified as “nuclear speckles,” which also contained
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Smith, C. D., and K. J. Chang. "Regulation of Brain Phosphatidylinositol-4-phosphate Kinase by GTP Analogues." Journal of Biological Chemistry 264, no. 6 (1989): 3206–10. http://dx.doi.org/10.1016/s0021-9258(18)94052-4.

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Pratt, Clifford, Yue-Jin Liu, Ting-Yi Chu, Karin Melkonian, Burton E. Tropp, and Robert Engel. "Phosphonolipids. 3. Phosphonic acid analogues of phosphatidylinositol and related materials." Canadian Journal of Chemistry 70, no. 8 (1992): 2135–41. http://dx.doi.org/10.1139/v92-268.

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A convergent synthesis of an isosteric phosphonic acid analogue of phosphatidylinositol has been accomplished in which a non-hydrolyzable P—C—C linkage is present in place of the normal P—O—C esteric linkage joining the phosphate and diacylglycerol portions of the molecule. The synthetic route used provides the configuration at each stereogenic center to correspond to that present in the biologically generated phospholipid. In addition, the approach provides asymmetric introduction of acyl functions, placing saturated and unsaturated acyl groups in the terminal and internal positions respectiv
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Morii, Hiroyuki, Tatsuo Okauchi, Hiroki Nomiya, Midori Ogawa, Kazumasa Fukuda, and Hatsumi Taniguchi. "Studies of inositol 1-phosphate analogues as inhibitors of the phosphatidylinositol phosphate synthase in mycobacteria." Journal of Biochemistry 153, no. 3 (2012): 257–66. http://dx.doi.org/10.1093/jb/mvs141.

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Graves, J. D., S. C. Lucas, D. R. Alexander, and D. A. Cantrell. "Guanine nucleotide regulation of inositol phospholipid hydrolysis and CD3-antigen phosphorylation in permeabilized T lymphocytes." Biochemical Journal 265, no. 2 (1990): 407–13. http://dx.doi.org/10.1042/bj2650407.

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A method of membrane permeabilization of T lymphocytes with the bacterial cytotoxin streptolysin O has allowed the effect of guanine nucleotide analogues on phosphatidylinositol metabolism and protein kinase C (PKC) activation to be investigated. The data demonstrate that, in permeabilized cells, phosphorylation of the gamma subunit of the CD3 antigen can be induced in response to the PKC activator phorbol 12,13-dibutyrate, the polyclonal mitogen phytohaemagglutinin (PHA) and the stimulatory guanine nucleotide analogue guanosine 5′-[gamma-thio]triphosphate (GTP[S]). Application of a pseudo-sub
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Xu, Yong, Stephanie A. Lee, Tatiana G. Kutateladze, Diego Sbrissa, Assia Shisheva, and Glenn D. Prestwich. "Chemical Synthesis and Molecular Recognition of Phosphatase-Resistant Analogues of Phosphatidylinositol-3-phosphate." Journal of the American Chemical Society 128, no. 3 (2006): 885–97. http://dx.doi.org/10.1021/ja0554716.

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Taylor, S. J., and J. H. Exton. "Guanine-nucleotide and hormone regulation of polyphosphoinositide phospholipase C activity of rat liver plasma membranes. Bivalent-cation and phospholipid requirements." Biochemical Journal 248, no. 3 (1987): 791–99. http://dx.doi.org/10.1042/bj2480791.

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The effect of the GTP analogue guanosine 5′-[gamma-thio]triphosphate (GTP[S]) on the polyphosphoinositide phospholipase C (PLC) of rat liver was examined by using exogenous [3H]phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)P2]. GTP[S] stimulated the membrane-bound PLC up to 20-fold, with a half-maximal effect at approx. 100 nM. Stimulation was also observed with guanosine 5′-[beta gamma-imido]triphosphate, but not with adenosine 5′-[gamma-thio]triphosphate, and was inhibited by guanosine 5′-[beta-thio]diphosphate. Membrane-bound PLC was entirely Ca2+-dependent, and GTP[S] produced both a d
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Lobasso, Simona, Patrizia Lopalco, Roberto Angelini, et al. "Coupled TLC and MALDI-TOF/MS Analyses of the Lipid Extract of the Hyperthermophilic ArchaeonPyrococcus furiosus." Archaea 2012 (2012): 1–10. http://dx.doi.org/10.1155/2012/957852.

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The lipidome of the marine hyperthermophilic archaeonPyrococcus furiosuswas studied by means of combined thin-layer chromatography and MALDI-TOF/MS analyses of the total lipid extract. 80–90% of the major polar lipids were represented by archaeol lipids (diethers) and the remaining part by caldarchaeol lipids (tetraethers). The direct analysis of lipids on chromatography plate showed the presence of the diphytanylglycerol analogues of phosphatidylinositol and phosphatidylglycerol, theN-acetylglucosamine-diphytanylglycerol phosphate plus some caldarchaeol lipids different from those previously
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Thèses sur le sujet "Phosphatidylinositol phosphate analogues"

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ORSATO, ALEXANDRE. "Studies on tumor drug targeting." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2011. http://hdl.handle.net/10281/19200.

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Tumor drug targeting is one of the most promising therapeutic strategies in oncology. The aim of this PhD work was the study of the essential features required for the assembly of tumor targeting conjugates.This work was focused on the deveploment of ligands for the GRP receptor that should function as carrier molecules for the targeting of tumor cells overexpressing this receptor. For this purpose, non-peptide GRP mimetics were designed, using a computer-based drug design technique, synthesized and tested. Two analogue compounds based on a bicyclic scaffold exerted an antagonist behaviour on
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Chapitres de livres sur le sujet "Phosphatidylinositol phosphate analogues"

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Bruzik, Karol S., Gialih Lin, and Ming-Daw Tsai. "Phosphorothioate Analogues of Phosphatidylinositol and Inositol 1,2-Cyclic Phosphate." In ACS Symposium Series. American Chemical Society, 1991. http://dx.doi.org/10.1021/bk-1991-0463.ch013.

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Schmidt, M., G. Vereb, M. Varsányi, D. Klix, C. E. Dreefs, and L. M. G. Heilmeyer. "Renaturation of Phosphatidylinositol 4- and Phosphatidylinositol 4-Phosphate 5′-Kinases Following Polyacrylamide Gelelectrophoresis in Presence of SDS. Studies on their Substrate Binding Requirements Using Synthetic Substrate Analogues." In Tyrosine Phosphorylation/Dephosphorylation and Downstream Signalling. Springer Berlin Heidelberg, 1993. http://dx.doi.org/10.1007/978-3-642-78247-3_24.

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Actes de conférences sur le sujet "Phosphatidylinositol phosphate analogues"

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de Chaffov de Courcelles, D., F. De Clerck, and P. Roevens. "EVALUATION OF THE PROPOSED FUNCTIONS OF PROTEIN KINASE C IN PLATELET SIGNAL TRANSDUCTION BY THE USE OF A DIACYLGLYCEROL KINASE INHIBITOR." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644632.

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Protein kinase C is suggested to play a major role in propagation as well as in termination of excitatory signal transduction in the platelet. Most of its properties were discovered by the use of synthetic diacylglycerol analogs or phorbol esters that directly stimulate protein kinase C. It is, however, unknown to what extent activation of the protein kinase C by these exogenously added compounds can be compared to that after receptor activation. To evaluate the role of protein kinase C in excitatory signal transduction, we transiently elevated the endogenous diacylglycerol level after recepto
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