Articles de revues : « Phased briefing »

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Purnama, Sita, Pawit M. Yusup et Nuning Kurniasih. « Hubungan perilaku pencarian informasi guru militer dengan hasil pembelajaran pembekalan angkutan TNI AD Cimahi ». Jurnal Kajian Informasi dan Perpustakaan 5, n^o 2 (31 mai 2018) : 191. http://dx.doi.org/10.24198/jkip.v5i2.12337.

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Information needs are necessary for humans to answer questions that are in the mind, in order to enhance their professions or main activities. The needs of each person are influenced by different situations, cognitions and physiological backgrounds. All aspects of human life require information which is expected to continuously support the improvement of life patterns toward increasing complexities. The purpose of this study was to identify and analyze the relationship of information seeking behavior by military instructors with the learning outcomes of transportation briefing of the Indonesian Army in Cimahi. This study used the correlational research method with the Spearman rank statistical test; study results showed: 1) a positive relationship between the information seeking behavior of the initiation phase and learning outcomes of transportation briefing; 2) a positive relationship between the information seeking behavior of the selection phase and the learning outcomes of transportation briefing; 3) a positive relationship between the information retrieval behavior of the exploration stage and the learning outcomes of transportation briefing; 4) a positive relationship between the information seeking behavior of the formulation stage and the learning outcomes of transportation briefing; 5) a positive relationship between the information collection stage collection behavior and the learning outcomes of transportation briefing; and 6) a positive relationship between the information seeking behavior of the presentation stage and the learning outcomes of transportation briefing. In conclusion, there is a positive relationship between information seeking behavior by military instructors and the learning outcomes of transportation briefing.

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Kong, Na-Hyung. « A Critical Analysis of the Regular Briefing on COVID-19 from the Perspective of Disaster Literacy ». Korean Language and Literature 122 (30 novembre 2022) : 33–68. http://dx.doi.org/10.21793/koreall.2022.122.33.

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The purpose of this study is to establish the concept of disaster literacy and to lay the foundation for the formation of disaster literacy discourse by presenting constituent factors. And from the perspective defined in this way, I tried to critically review the text structure and language usage patterns of the regular briefing related to COVID-19 by the Central Disease Control Headquarters. Ultimately, this study attempted to find ways to improve the use of disaster language that fostered disaster literacy capabilities in public areas. This study first defined disaster literacy based on previous studies and clarified the factors constituting disaster literacy to prepare a literacy measurement tool. Through this, this study emphasized that in the case of disaster literacy, the stages of disaster development are diverse, and the contents of the required literacy should be changed according to the phase of the disaster. In this paper, disaster literacy was defined in this way in three dimensions, and based on that point of view, text analysis was conducted on 190 regular briefings related to COVID-19 by the Central Disease Control Headquarters. Through this, this study attempted to examine the structural aspects of the texts, examine the characteristics of the language used in each structure, and derive improvements.

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Kleber, John, Robert Thomas, Cassandra Domingo et Beth Blickensderfer. « Measuring Mental Models : General Aviation Pilots’ Understanding of Preflight Weather ». Proceedings of the Human Factors and Ergonomics Society Annual Meeting 66, n^o 1 (septembre 2022) : 1997–2000. http://dx.doi.org/10.1177/1071181322661216.

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Weather has contributed to hundreds of General Aviation accidents. Research suggests inadequate preflight planning and lack of aviation weather knowledge are contributing factors. This study describes the development of three mental model measures (departure, enroute, and arrival) designed to assess pilots’ understanding of current and forecasted conditions. Each measure requires pilots (n=23) to evaluate weather conditions (flight category) at different regions within the flight area. A two-way mixed ANOVA examined differences in pilots’ understanding of flight category across three preflight weather briefing conditions (flight services call, self-briefing, and a combined condition) and three phases of flight (POF). No significant interaction occurred between briefing condition and POF on pilots’ ability to identify the correct flight category. However, significant differences in pilots’ understanding of weather conditions occurred between phases. Pilots were most effective at assessing flight category/weather on the enroute mental model measure and least effective at assessing weather forecasted surrounding arrival.

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He, Zi Qi. « A Computer-Based Method for Building Design and Construct ». Advanced Materials Research 575 (octobre 2012) : 27–31. http://dx.doi.org/10.4028/www.scientific.net/amr.575.27.

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We have developed a framework for the design of a computer-based LCA tool for the briefing stage of design. The tool helps designer by producing directions, guidelines and concepts for the solution. LCA tool is created using two main phases. First a knowledge-base is created then a computer system is built using the knowledge-base. In this paper we described our approach for building the knowledge-base, and briefly overviewed the computer system which will be described in a sequel paper. The developed tool has several advantages: it provides a systematic way of analysis for the briefing stage and incorporates sustainability issues on it. By sorting information into a hierarchy, it is relatively easy to develop a strategy and research plan for uncovering missing information.

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Deng, Jun, Wang-ru Wei, Wei-lin Xu, Zhong Tian et Fa-xing Zhang. « Briefing : Experimental study on air-phase frequency in self-aerated flow ». Proceedings of the Institution of Civil Engineers - Water Management 168, n^o 4 (août 2015) : 153–61. http://dx.doi.org/10.1680/wama.14.00090.

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Khosrowshahi, Farzad. « Enhanced project brief : structured approach to client-designer interface ». Engineering, Construction and Architectural Management 22, n^o 5 (21 septembre 2015) : 474–92. http://dx.doi.org/10.1108/ecam-10-2014-0128.

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Purpose – The focus of this work is on the client-designer interface where decisions have significant impact over the lifecycle of the project. Therefore, the briefing stage is examined in the context of clients’ needs which is divided into project-based strategy and broader clients’ strategy. The purpose of this paper is to address the pitfalls in the briefing process which has been attributed to the shortcomings in the client-designer communication interfaces. This will be achieved by developing an automated brief generation framework. The research examines the efficiency of standard approaches to modelling and design, and the benefits that these methodologies have offered to the computer industry. The work reviews the similarities between the two industries and argues in support of the potential benefits in adopting a standard methodology in the construction industry. The structure upon which the framework is developed is based on system analysis and design methodology (SSADM) which has proven to be an effective platform used within the software development industry. Design/methodology/approach – SSADM is an established methodology within the software development industry. The paper will demonstrate that due to fundamental similarities between the construction and software development industries, SSADM is likely to offer a viable platform upon which an automated enhanced brief generation model is developed for use in the construction industry. The construction design and construction process will be mapped on SSADM high-level definition before focusing and honing on the design phase. The methodology for the development of the framework will be based on the rationalist approach of generating knowledge through reasoning leading to model-building. Findings – A model that is based on SSADM is proposed for the design development phase of construction projects. In order to shape the project strategy, the model considers the combined role of clients’ requirements with organisation strategy and environmental factors. The paper has shown that it is feasible to increase the automation of the briefing process and enhanced the briefing output. The model here does not diminish the importance of direct communication between the client and the design team. It provides a more structured way of doing so, while taking advantage of vast array of data and technology in order to improve the brief outcome. Research limitations/implications – From practical perspective, the proposed framework is in its formative stage, thus requiring incremental refinement through several case studies. This is particularly true about the AI components of the system which typically rely on extensive data representing the real-case scenarios. Therefore, the work invites further research into the examination of various parts as well as the overall system. Practical implications – There are several ways by which construction projects are procured. There may be fluctuation in their rate of usage, but while there is no indication of any procurement option fading, new ones such as PPP and PFI are periodically introduced. The existence of this diversity is indicative of the fact that the industry tends to respond to problems rather than attempting to instigate a measured solution supported by theoretical underpinning. Subsequently, there have been suggestions of a communication and information discourse between actors and within processes involved in project lifecycle. This project is aimed at addressing the gap in the client-designer communication. The automated approach to brief generation will lead to better briefs while reducing ambiguities as well as the overhead associated with brief generation. Social implications – The quality of project brief has a significant impact on decisions at the design stage. In turn, these decisions will influence all phases of construction project lifecycle. The briefing session and requirement analysis of a construction project can be very difficult for inexperienced clients particularly for complex projects. Therefore, there is potential for the process of client-requirement-analysis to be optimised. The work promises to improve the quality of the briefing process, thus helping clients to realise their intended objectives and minimise resource waste. Originality/value – The work builds on the commonalities of the construction and software development industries and takes advantage of the advancements in the latter. In doing so, project quality is defined quantitatively which is used to develop project strategy in a three-dimensional space. The development of the model was also contingent upon enhancement of artificial neural network structure.

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Adams, Mary, Rick Iedema, Alexander Edward Heazell, Maureen Treadwell, Maria Booker, Charlotte Bevan, Julie Hartley et Jane Sandall. « Investigation of the critical factors required to improve the disclosure and discussion of harm with affected women and families : a study protocol for a qualitative, realist study in NHS maternity services (the DISCERN study) ». BMJ Open 12, n^o 2 (février 2022) : e048285. http://dx.doi.org/10.1136/bmjopen-2020-048285.

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Patients and families are entitled to an open disclosure and discussion of healthcare incidents affecting them. This reduces distress and contributes to learning for safety improvement. Complex barriers prevent effective disclosure and continue in the English NHS, despite a legal duty of candour. NHS maternity services are the focus of significant efforts to improve this. There is limited understanding of how, and to what effect, they are achieving this.Methods and analysisA 27-month, three-phased realist evaluation identifying the critical factors contributing to improvements in the disclosure and discussion of incidents with affected families. The evaluation asks ‘what works, for whom, in what circumstances, in why respects and why?’.Phase 1: establish working hypotheses of key factors and outcomes of interventions improving disclosure and discussion, by realist literature review and in-depth realist interviews with key stakeholders (n=approximately 20]Phase 2: refine or overturn hypotheses, by ethnographic case-study analysis using triangulated qualitative methods (non-participant observation, interviews (n=12) and documentary analysis) in up to 4 purposively sampled NHS trusts.Phase 3: consider hypotheses and design outputs during seven interpretive forums.Ethics and disseminationPhase 1 study approval by King’s College London’s Ethics Panel (BDMRESC 22033) and National Research Ethical Approval for Phases 2–3 (IRASID:262197) (CAG:20/CAG/0121) (REC:20/LO/1152). Study sponsorship by King’s College London (HS&DR 17/99/85).Findings to be disseminated through tailored management briefings; clinician and family guidance (written and video); lay summaries, academic papers, and report with outputs tailored to maximise academic and societal impact. Views of women/family groups are represented throughout.

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PIETREK, Grzegorz. « LEVELS, STRUCTURE AND TASKS OF PUBLIC ADMINISTRATION CRISIS MANAGEMENT ». Scientific Journal of the Military University of Land Forces 161, n^o 3 (1 juillet 2011) : 375–88. http://dx.doi.org/10.5604/01.3001.0002.3126.

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As part of recessionary management, there are bodies as well as other organizations of government and provincial administration subordinated to the governor, and other forces at his/her disposal prepared and concentrated on carrying out tasks in the local area, including the Polish armed forces units and subunits. Security management in an unsafe area is carried out by the leader of the special service, guard or inspection.In the case of other events and competence problems, it is the governor who deals the solution. The procedure of dealing with this management is a decision cycle which includes: the decision phase and stages connected with gaining, changing and using information. The result of this process is supposed to be the decision, the intention and the plan of crisis management as well as the tasks prepared for specific organizations at the disposal of the administrative body.Every decision cycle is divided into four basic, penetrating phases which are connected, the first of which is defined as the decision of placement; then there should be the planning phase consisting of four stages. This is followed by tasking, which aims at obligating the staff to carry out the plan. The most effective way to obligate them is to do it personally to heads, service, inspection or guard commanders by the governor, borough leaders or village heads. It takes place during a special briefing. The last but not least is the phase of controlling.

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Norden, Günther van. « Der politische Karl Barth in den Offenen Briefen ». Evangelische Theologie 63, n^o 1 (1 janvier 2003) : 34–55. http://dx.doi.org/10.14315/evth-2003-0107.

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Zusammenfassung Der Verfasser zeigt in diesem Aufsatz, dass Karl Barth in den verschiedenen Phasen seines Denkens, wie in den Offenen Briefen deutlich wird, die dialektische Position durchgehalten hat: Die Botschaft der Kirche, die Verkündigung des Evangeliums, ist ohne Anknüpfung das Ganz Andere und sie ist zugleich in Anknüpfung an die Lebenswirklichkeit implizit per se politisch. Aber diese Dialektik ist in den verschiedenen Phasen unterschiedlich akzentuiert. Sie verschiebt sich mit dem Anwachsen des nationalsozialistischen Unrechts, also mit der Herausforderung durch die Lebenswirklichkeit immer klarer zu einer expliziten politischen Predigt. Dabei wird deutlich, dass der »theologisch-kirchliche Konflikt« mehr und mehr als »politischer Konflikt« offenbar wird. Entscheidend für politische Bewertungen sind also nicht Theologien, sondern die unterschiedlichen Sozialisations- und Erfahrungsbereiche, die Prägungen durch die historischen Kontexte.

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Schwägele, Sebastian, Birgit Zürn, Heide K. Lukosch et Maria Freese. « Design of an Impulse-Debriefing-Spiral for Simulation Game Facilitation ». Simulation & ; Gaming 52, n^o 3 (15 avril 2021) : 364–65. http://dx.doi.org/10.1177/10468781211006752.

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Background. Simulation gaming sessions can be understood as a sequence of briefing, game play, and debriefing - with feedback loops and iterative steps in between. Often, these sessions are supported by a facilitator, who organizes the session, sets learning goals, and guides the players through briefing, game play and debriefing ( Taylor, Backlund & Niklasson, 2012 ), which we call facilitation. Debriefing is a vital part of the facilitation process, as according to Crookall (2010) and Kriz (2010) , it facilitates learning. Contrary to many traditional models that locate the debriefing phase at the very end of a simulation gaming session, we conceptualize debriefing as reflection moments during the whole session, in which participants have the opportunity to reflect on their game play, experiences, and learnings. Facilitation is the process of enabling participants to address challenging situations of the game play, and make connections between the game play and the real environment the game refers to throughout the simulation gaming session. Method & Results. We analysed existing debriefing literature within the Simulation & Gaming journal. This review revealed that many existing approaches do not sufficiently consider changing needs of participants during a simulation gaming session to allow for a direct reflection on what is happening. Instead, a large number of debriefing approaches focus on a post-action reflection only. Moreover, the approaches analysed in our article often are abstract and only provide scarce practical recommendations. In addition to the literature review, we draw conclusions from observations of our own work in and with simulation gaming sessions. Based on the related and our own work, we propose a new model for simulation game facilitation, which better connects moments of reflection with the game play - the Impulse-Debriefing-Spiral. Conclusions. We provide a holistic understanding of debriefing that helps facilitators when implementing simulation games for learning purposes. Our model, called the Impulse-Debriefing-Spiral, conceptualizes the role of facilitation between briefing and debriefing throughout the whole process of a simulation gaming session - starting with its planning to reacting on emerging needs of the participants in between, up to closing the session as last step before transferring new knowledge and competencies into a new context (learning transfer).

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Jansen, Rob J. G., et Marino van Zelst. « The Multiple Facilitator : Scientists, Sages and Rascals ». Simulation & ; Gaming 52, n^o 3 (28 janvier 2021) : 273–89. http://dx.doi.org/10.1177/1046878121989376.

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Background. Games are designed to help participants think about, understand, sharpen their problem statement as well as the specific objectives to be achieved to escape the problem situation. When participants prepare for the game (briefing), interact in the simulated environment (gameplay), and self- or jointly reflect about the gameplay they faced in terms of intended and unintended learning experiences (debrief), they benefit or suffer from facilitating that can or cannot fully cater to their needs. To support the participants to explore and resolve the problem situation in order to achieve learning goals, we propose that facilitators can make use of role shifts during gameplay. Method. To capture the role shifts in the gameplay phase we studied game runs of the MicroTech game. The MicroTech game is a free-form game in which participants play the role of top management team or division managers in a multiunit organization. Results. We analyzed the role shifts we experienced as facilitators by elaborating on game events and how we could manage those events differently in future game runs if necessary. We show a need for facilitators to be able to embody multiple roles in the case of policy gaming that are in fit with the different phases, while there is a simultaneous need to shift within phases in order to keep participants moving and stimulating them to work towards the learning goals. Conclusion. Gaming/simulation facilitators should explore what multiplicity is required of them to make the game a success. Although this may seem normal practice to well-prepared and professionally trained facilitators, this may be particularly important for novice facilitators.

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Dyson, Lisa, Mary J. Renfrew, Alison McFadden, Felicia McCormick, Gill Herbert et James Thomas. « Policy and public health recommendations to promote the initiation and duration of breast-feeding in developed country settings ». Public Health Nutrition 13, n^o 1 (18 août 2009) : 137–44. http://dx.doi.org/10.1017/s136898000999067x.

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AbstractObjectiveTo develop policy and public health recommendations for implementation at all levels by individuals and organisations working in, or related to, the field of breast-feeding promotion in developed country settings, where breast-feeding rates remain low.DesignTwo research phases, comprising (i) an assessment of the formal evidence base in developed country settings and (ii) a consultation with UK-based practitioners, service managers and commissioners, and representatives of service users. The evidence base included three systematic reviews and an Evidence Briefing. One hundred and ten studies evaluating an intervention in developed country settings were assessed for quality and awarded an overall quality rating. Studies with a poor quality rating were excluded. The resulting seventy studies examined twenty-five types of intervention for breast-feeding promotion. These formed the basis of the second consultation phase to develop the evidence-based interventions into recommendations for practice, which comprised (i) pilot consultation, (ii) electronic consultation, (iii) fieldwork meetings and (iv) workshops. Draft findings were synthesised for two rounds of stakeholder review conducted by the National Institute for Health and Clinical Excellence.ResultsTwenty-five recommendations emerged within three complementary and necessary categories, i.e. public health policy, mainstream clinical practice and local interventions.ConclusionsThe need for national policy directives was clearly identified as a priority to address many of the barriers experienced by practitioners when trying to work across sectors, organisations and professional groups. Routine implementation of the WHO/UNICEF Baby Friendly Initiative across hospital and community services was recommended as core to breast-feeding promotion in the UK. A local mix of complementary interventions is also required.

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Larsen, Jesper Kranker, Lene Faber Ussing, Thomas Ditlev Brunoe et Søren Munch Lindhard. « The Project Management Process of Planning and Budgeting in Public Construction Projects ». International Journal of Information Technology Project Management 6, n^o 4 (octobre 2015) : 20–33. http://dx.doi.org/10.4018/ijitpm.2015100102.

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Budgeting and scheduling are central elements in all projects through diverse estimates that are defining the level of project outcome success. It is therefore relevant to study how large public construction agencies apply cost and time scheduling in their projects. The study objective is firstly, to comprehend the process of cost and time scheduling in the initial phases of a project. Secondly, to discover which factors stimulate budget and deadline increases in publicly funded construction projects. Applied data collection is based on semi-structured interviews with publicly agency employed project and property managers. Findings demonstrate that too early decision making disrupt the deadline and total cost in the client briefing stage. Due to lack of clear defined project scope and user requirements are too optimistic. The subsequent project stages are thus pushed by an earlier decided deadline and budget, where following complications within the project organizations were found to stimulate budget and scheduling increases.

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Wakit, Saipul, et Ainur Rhain. « Lecturer Career Management at Muhammadiyah Higher Education in the Era of Pademi Covid-19 (Case Study at UM Jember) ». Halaqa : Islamic Education Journal 5, n^o 1 (4 avril 2021) : 73–87. http://dx.doi.org/10.21070/halaqa.v5i1.1289.

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The large number of lecturers in Indonesia is clear evidence that there is still a large number of people who choose lecturers as their profession and career. So that the career of a lecturer in a university requires serious and professional management. One of the lecturers' career management processes in tertiary institutions can be done with career management. The purpose of this study has concrete objectives, namely to identify and describe the planning, development and career decision-making processes of lecturers at Muhamamdiyah university in the Covid-19 Pademi Era. The research method used a qualitative approach with a case study design at UM Jember with data collection techniques through interviews, observation and documentation. Lecturer career management at the University of Muhammadiyah during the Covid-19 pandemic includes several stages, namely career planning, career development and career decision making. Each of these stages has an operational process with its own methods and objectives. In lecturer career planning, it is divided into two, namely individual and organizational career planning which consists of several processes, namely the planning phase, the briefing phase, the development phase and the evaluation phase. Of all the stages of career management during the Covid-19 pandemic above, starting from planning, development and decision making, it is not much different from the conditions before the pandemic. But what distinguishes it is in terms of the career development method which in its implementation uses an online system with virtual methods, geogle meet and room zoom.

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Hassanain, Mohammad A., Ameen Bin-Mohanna, Abdul-Mohsen Al-Hammad et Muizz O. Sanni-Anibire. « Challenges to the implementation of building management systems in Saudi Arabia ». Built Environment Project and Asset Management 7, n^o 2 (11 mai 2017) : 130–42. http://dx.doi.org/10.1108/bepam-05-2016-0022.

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Purpose The purpose of this paper is to present an assessment of the challenges to the implementation of building management systems (BMS) in Saudi Arabia, during the life cycle of building projects. Design/methodology/approach Review of literature and interviews were conducted with professionals to identify and synthesize the challenges to the implementation of BMS in Saudi Arabia. This formed the basis of three questionnaire surveys that were designed utilizing a five-point Likert scale, and consisted of 32 challenges. The surveys were assessed by representatives of architectural/engineering (A/E) firms, BMS installation sub-contractors and facilities managers to calculate the effect index of each challenge. Findings The top influential challenges pertaining to the briefing and design phase includes “inappropriate selection of the BMS,” “inappropriate selection of the A/E team”; installation and final acceptance phase includes “inappropriate selection of sub-contractors to install the BMS” and “inappropriate selection of the BMS suppliers,” operation and maintenance phase includes “inadequate initial training for the BMS facility personnel,” “poor operation and maintenance activities.” Practical implications The paper is of practical benefit to stakeholders in the building industry, as it allows for the development of an effective BMS implementation plan. Originality/value The study increases the level of awareness in the building industry about the challenges that influence the implementation of BMS.

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Fazryansyah, M. Irfan, Heriyani Agustina et Nuruzzaman Nuruzzaman. « Manajemen Redaksional Pada Surat Kabar Harian Umum Radar Cirebon (Studi Deskriptif Kualitatif Manajemen Redaksional pada Surat Kabar Harian Umum Radar Cirebon Periode Januari-Mei 2013) ». Jurnal ASPIKOM 2, n^o 2 (20 janvier 2014) : 85. http://dx.doi.org/10.24329/aspikom.v2i2.62.

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Mass media after the era of reform becomes the mass communication facility and instrument shaper of public opinion , it is helping in human life to exchanging ideas, sharing of experience and information in the volume of a relatively large. This research aims to understand planning, organizing, mobilizing and supervision in the management of editorial on daily newspaper of Radar Cirebon. A method of this research is descriptive qualitative, data was gathered by direct interview, observasion and availability of literature studies. Based on covered can be drawn conclusions that ( 1 ) In the planning stages, daily newspaper of Radar Cirebon well to plan, it is seen from the success of meeting and a meeting of the editor. ( 2 ) the organizing stages, the editor management has forming the organization structure and their duty to each personel.( 3 ) The mobilization phase is very important to editor management in daily newspaper of Radar Cirebon, because of mobilizarion, the management of material goes well, start from the reporting process, writing, editing till becoming the news. (4) In the phase supervision in editorial management of daily newspaper of Radar Cirebon conducted in the form of direct briefing to reporters during a news manuscript edited by the editor still experiencing a shortage of data.

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Muharam, Ricky Santoso. « Bimbingan Teknis Kinerja Pengawas Tempat Pemungutan Suara pada Pilkada 2020 di Era Pandemi Covid 19 ». Jurnal Surya Masyarakat 4, n^o 1 (29 novembre 2021) : 10. http://dx.doi.org/10.26714/jsm.4.1.2021.10-17.

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Understanding of duty as a supervisor of polling places certainly needs to be given a thorough of various materials ranging from regulations on the selection of regional heads, regulations on the supervision of regional head elections during the Covid-19 pandemic, the code of ethics and the use of the election surveillance system (SIWASLU) need to be clearly understood. This activity is carried out in two stages, namely technical guidance phase 1 and technical guidance phase 2 starting from the preparatory stage, material briefing, practice, posttest and questionnaire filling. The results of this activity resulted in understanding for members of the polling station supervisor (PTPS) in carrying out their responsibilities from regulatory understanding, supervision of health protocols as supervisors, code of ethics and commitment to contribute to becoming PTPS. PTPS commitment to be able to contribute back to become a member of the TPS election supervisor for the 2024 elections correspondents answered 28 people (47.5%) willing to return to become PTPS in the upcoming elections or local elections, 28 people (47.5%) answer still in doubt or maybe willing to return to become PTPS and 3 people or about (5.1%) do not want to join the PTPS for the 2024 regional elections or presidential elections.

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Poth, Cheryl N., Okan Bulut, Alexandra M. Aquilina et Simon J. G. Otto. « Using Data Mining for Rapid Complex Case Study Descriptions : Example of Public Health Briefings During the Onset of the COVID-19 Pandemic ». Journal of Mixed Methods Research 15, n^o 3 (19 mai 2021) : 348–73. http://dx.doi.org/10.1177/15586898211013925.

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The methodological purpose of this article is to demonstrate how data mining contributes to rapid complex case study descriptions. Our complexity-informed design draws on freely accessible datasets reporting the public health response surrounding the onset of the COVID-19 pandemic in Alberta (Canada) and involves the cross analysis of integrated findings across six periods of fluctuation identified in the initial quantitative phase of a convergent sequential approach. We discuss how our case meta-inferences, informing how public health briefings can build credibility and trust, were derived by attending to three key concepts of complex adaptive systems: emergence, interdependence, and adaptation. This article serves as an essential reference for using data mining within a case study–mixed methods design for studying complex phenomena.

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Seichter, Hartmut, Dirk Donath et Frank Petzold. « TAP – The Architectural Playground : A C++ Framework for Scalable Distributed Collaborative Architectural Virtual Environments ». International Journal of Architectural Computing 1, n^o 1 (janvier 2003) : 24–32. http://dx.doi.org/10.1260/147807703322467306.

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Architecture is built information [1]. Architects have the task of restructuring and translating information into buildable designs. The beginning of the design process, where the briefing is transformed into an idea, is a crucial phase in the design process. It is where the architect makes decisions that influence the rest of the design development process [2]. It is at this stage where most information is unstructured but has to be integrated into a broad context. This is where TAP is positioned – to support the architect in finding solutions through the creation of spatially structured information sets without impairing creative development. We want to enrich the inspiration of an architect with a new kind of information design. A further aspect is workflow in a distributed process where the architect's work becomes one aspect of a decentralised working pattern. The software supports collaborative work with models, sketches and text messages within a uniform environment. The representations of the various media are connected and combined with each other and the user is free to combine them according to his or her needs.

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Geekiyanage, Devindi, Terrence Fernando et Kaushal Keraminiyage. « Mapping Participatory Methods in the Urban Development Process : A Systematic Review and Case-Based Evidence Analysis ». Sustainability 13, n^o 16 (11 août 2021) : 8992. http://dx.doi.org/10.3390/su13168992.

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Despite the fact that vulnerable communities are the most affected by unplanned cities, considerably less attention has been given to involving them in urban development in order to ensure equitable outcomes. In this regard, there is an urgent need for governments to introduce and enforce processes that allow citizens, including vulnerable communities, to participate in development planning and policymaking. However, at present, there is a lack of guidance for practitioners regarding the definition of a clear purpose of community engagement and the selection of appropriate participatory methods to fulfil the set purpose. This study provides a thorough account of the participatory methods that can be used to achieve various engagement goals throughout the urban development process. This structured literature review used 71 reports published from 2000 to 2020. The review revealed 34 participatory methods, wherein most of the methods are devoted to informing, consulting and involving communities, whilst only a few methods are available for interactive public participation that supports true collaboration and empowerment. The study identified 12 purposes of community engagement in urban development, and mapped the 34 participatory methods for achieving them. The analysed case studies showed that the current community engagement practices are mainly in the pre-design and briefing stages of the urban development processes, and that most projects are aiming to achieve the ‘inform’ and ‘consult’ levels of engagement, with a few aiming to achieve the ‘involve’ and ‘collaborate’ levels. This study shows that community engagement is often overlooked during the professional design, development and post-development phases. The paper presents an onion model which can be used by practitioners to choose appropriate participatory methods based on the intended urban development phase, the engagement level and the purpose of the community engagement.

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Liou, Sarah Y., Kimbach T. Tran, Jennifer M. Stephens, Nneka C. Onwudiwe et Marc F. Botteman. « Economic Impact of Adverse Events in Chronic Myelogenous Leukemia : A Cost of Treatment Analysis of Dasatinib. » Blood 108, n^o 11 (16 novembre 2006) : 3309. http://dx.doi.org/10.1182/blood.v108.11.3309.3309.

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Abstract OBJECTIVES: With a greater focus on costs in today’s health care markets, it is important to evaluate overall costs and quality of care associated with new therapies in cost-effectiveness analyses. Adverse events (AEs) associated with cancer therapies often result in substantial economic costs and negative impacts on patient quality of life. AEs may also affect adherence to therapy and result in suboptimal treatment outcomes. Important AEs of dasatinib in chronic myelogenous leukemia (CML) patients who are resistant to imatinib include neutropenia, thrombocytopenia, anemia, gastrointestinal hemorrhage, central nervous system hemorrhage, and fluid retention leading to effusions and heart dysfunction. This study evaluated the total cost of treatment with dasatinib in patients with chronic, accelerated, and myeloid blast phase CML, taking into account both drug and AE-associated costs. METHODS: A literature-based economic model was developed to examine the short-term potential impact of AEs in patients with CML treated with dasatinib. The incidence rates of Grade 3/4 AEs were obtained from the SPRYCEL™ (dasatinib) package insert. The AEs were assumed to occur within the first 6 months of treatment. The costs associated with the AEs were obtained from published medical literature and the 2003 Healthcare Cost and Utilization Project database of mean hospital charges by principal diagnosis, converting to costs using a Medicare cost-to-charge ratio of 0.55. Dasatinib dosing assumptions were based on the FDA briefing documents of the SPRYCEL™ filing submission presented at the June 2, 2006 Oncology Drug Advisory Committee meeting. The initial dose for dasatinib was 70 mg twice daily based on the package insert. Patients were assumed to remain on treatment for 6 months. However, dose interruption of 7–14 days during the first 3 months of treatment and dose reduction to 50 mg twice daily in the second 3 months of treatment were assumed in 46–55% and 9–10% of patients, respectively. Drug costs were based on wholesale acquisition cost. Univariate and multivariate sensitivity analyses were conducted. All costs were adjusted to 2006 U.S. dollars using the medical care component of the consumer price index. RESULTS: In the base case analysis, the expected 6-month per-patient cost of treatment for dasatinib was $31,528 for chronic phase, $44,340 for accelerated phase, and $48,666 for myeloid blast phase. Six-month drug cost alone was $22,284 per patient in each phase. Grade 3/4 AEs accounted for approximately 29%, 50%, and 54% of the total cost of care for chronic, accelerated, and myeloid blast phases, respectively. Sensitivity analysis showed that the 6-month cost of Grade 3/4 AEs may range from $5,235–$10,696 for chronic, $16,109–$23,723 for accelerated, and $12,971–$27,551 for myeloid blast phases. Primary cost drivers were the hematologic AEs. CONCLUSIONS: This study provides an estimate for the total cost of treatment with dasatinib that considers treatment costs for severe AEs associated with therapy. These results highlight the importance of including treatment-related AEs in addition to drug costs when assessing the economic value of treatment options for CML. Future studies should expand the time horizon of the analysis and include recurring AEs to more comprehensively evaluate the overall economic impact of AEs with dasatinib.

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Elf, Marie, Maria Svedbo Engström et Helle Wijk. « Development of the Content and Quality in Briefs Instrument (CQB-I) ». HERD : Health Environments Research & ; Design Journal 5, n^o 3 (avril 2012) : 74–88. http://dx.doi.org/10.1177/193758671200500308.

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Objective: The Content and Quality in Briefs Instrument (CQB-I) was designed to develop a valid and reliable audit instrument to examine the content and quality of information in documents (briefs) created in the early stages of designing healthcare environments. Background: The importance of effective briefing has been emphasized in many research studies during the past two decades. However, there is no developed instrument for auditing the content and quality of these documents. Methods: The study had a methodological and developmental design based on an established methodology for instrument development and validation. The development process consisted of three main phases: (1) item generation and scale construction; (2) assessment of face and content validity, and (3) testing of the reliability. To obtain face and content validity, expert panels reviewed the CQB-I. Content validity was assessed using the Content Validity Index (I – CVI = item level, S – CVI = scale level). Reliability was tested by test-retest and inter-rater reliability. Results: CQB-I was found to have good content validity (I − CVI = 0.78–1.0 and S – CVI = 0.98). Inter-rater reliability was acceptable (Spearman's correlation = 0.62) and stability was considered high for both raters (83% and 88%, respectively).

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Mutamima, Anisa, Nurfatihayati Nurfatihayati, Panca Setia Utama, Edy Saputra, Rozanna Sri Irianty et Feblil Huda. « Optimalisasi Produksi Sari Kedelai Sehat dalam Upaya Pembinaan Ibu Rumah Tangga di Desa Kualu, Kecamatan Tambang, Kabupaten Kampar ». PengabdianMu : Jurnal Ilmiah Pengabdian kepada Masyarakat 7, n^o 6 (28 novembre 2022) : 792–97. http://dx.doi.org/10.33084/pengabdianmu.v7i6.3991.

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Mutiara Ayu is a Micro, Small, and Medium Enterprise (MSME) which was founded by a group of housewives in Mutiara Kualu 8 Housing, Kualu Village, Tambang District, Kampar Regency, which produces Healthy Soybean Extract. Since its establishment in November 2020, MSME Mutiara Ayu has been experiencing various problems in running its business. The University of Riau Abdimas team, in partnership with MSME Mutiara Ayu, provided assistance to solve the problems being faced in the form of increasing knowledge and skills to improve product quality and quantity. The community partnership scheme service program was carried out for two months, namely July – August 2022, involving Real Work Lecture (Kukerta) students. This program was carried out in several stages of implementation, namely: (1) The preparation stage includes coordination with partner MSMEs, analysis of business conditions, recruitment, briefing with the community service team and students, coordination with various related parties, identification of needs, and analysis of instruments, (2) The implementation phase includes the provision of instruments and training, technical guidance, and assistance. (3) The monitoring and evaluation phase includes coordination with partner MSMEs, village parties, and Kukerta students. The results achieved in the Kukerta-integrated Abdimas program are an increase in product quality and quantity as well as an increase in the knowledge and skills of MSME Partners related to production and business management, which is expected to increase Mutiara Ayu's MSME income in the future.

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Katikireddi, Srinivasa Vittal, Daniel Kopasker, Anna Pearce, Alastair H. Leyland, Mikael Rostila et Matteo Richiardi. « Health Equity and Its Economic Determinants (HEED) : protocol for a pan-European microsimulation model for health impacts of income and social security policies ». BMJ Open 12, n^o 7 (juillet 2022) : e062405. http://dx.doi.org/10.1136/bmjopen-2022-062405.

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IntroductionGovernment policies on taxation and social security are important determinants of population health outcomes and health inequalities. However, there is a shortage of evidence to inform policymakers of the health consequences of such policies. The Health Equity and Its Economic Determinants project aims to assess the potential impacts of different taxation and social security policies across Europe on population health and health inequalities using a computer-based simulation that provides projections over multiple health domains.Methods and analysisIn the first phase, key input parameters for the model will be estimated using estimation techniques that control for the effects of prior exposure on time-varying confounders and mediators (g-methods). The second phase will involve developing and validating the microsimulation model for the UK. Policy proposals, developed with policymakers, will be simulated in the third phase to investigate the impacts of income tax and social security changes on population health and health inequalities. In the final phase, the microsimulation model will be extended across other European countries.Ethics and disseminationThis project will use deidentified secondary data for which ethical approval and consents were received by the original data collectors. No further ethical approval will be required for our main analytical datasets. Dissemination plans include academic publications, conference presentations, accessible policy briefings, mass media engagement and a project website. Both the syntax and the underlying synthetic data for the HEED microsimulation model will be made freely available through GitHub and the project website.

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Fotaris, Panagiotis, et Theodoros Mastoras. « Room2Educ8 : A Framework for Creating Educational Escape Rooms Based on Design Thinking Principles ». Education Sciences 12, n^o 11 (29 octobre 2022) : 768. http://dx.doi.org/10.3390/educsci12110768.

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By immersing learners in a playful, interactive, and engaging experience, Educational Escape Rooms (EERs) have been found to enhance learners’ motivation, help them to develop 21st century skills, and improve knowledge acquisition. As research into EERs is still in a preliminary phase, no unified framework about how to design them has been established yet. Additionally, existing frameworks rarely validate the quality and efficacy of the frameworks themselves in terms of usability and usefulness. Therefore, the present paper proposes Room2Educ8, a learner-centred framework for EER design that follows Design Thinking principles. It provides detailed heuristics for empathising with learners, defining learning objectives and constraints, adding narrative, designing puzzles, briefing and debriefing participants, prototyping and playtesting, documenting the whole process, and evaluating the EER experience. A mixed-methods internal validation study based on Instructional Design model validation was conducted with 104 postgraduate students between 2018–2022 to assess the framework’s integrity and use. The study findings suggest that Room2Educ8 can be proposed as a valid tool for developing a wide range of EER types that cover a variety of topics. Its well-described and practical steps make it appropriate for educators regardless of a lack of prior experience in EER design.

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Atmika, I. K. A., I. G. A. K. Suriadi et I. D. G. A. Subagia. « PENINGKATAN PARTISIPASI MASYARAKAT DALAM PENGELOLAAN POTENSI DESA BERBASIS IPTEK DI DESA BALUK ». Buletin Udayana Mengabdi 17, n^o 1 (1 janvier 2018) : 140. http://dx.doi.org/10.24843/bum.2018.v17.i01.p24.

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The themes of the KKN-PPM program in Baluk village are: Empowerment and Improvement ofcommunity participation in the management of the potential of science and technology-basedvillages to Mandiri villages through programs such as: public health programs: householdsanitation counseling and counseling of clean and healthy lifestyle in children. school children.Environmental program: reforestation activities in the area along the village road. Increasedproductivity of community / business groups in the production of soy milk through the introductionand application of blender machine technology. Cost-efficiency with the introduction and application of biogas / biogas portable biogas technology with the use of cow dung for a day-to-dayenergy source. Increased public participation in all KKN-PPM activities. Increased communityself-reliance in continuing every program that has been accompanied during KKN-PPM activities.Method of implementation of activities is divided into three stages. The first stage is preparationand briefing, second phase of implementation of activities in the field, and third stage evaluationand monitoring for correction and refinement of program sustainability. Preparatory phase beginswith field supervisors and students with the village apparatus and community leaders to determinethe priority scale of activities based on the conditions and potentials that exist in the community,this activity was held on July 20, 2017. The implementation of activities carried out withcounseling and practice in the field , as well as mentoring by students participating KKN during thefield. The dedication activity is held for one month starting from July 22, 2017 until August 27,2017. While the third stage is the evaluation and monitoring conducted by the team of fieldsupervisors and coordinators of KKN to see the impact and sustainability of programs that havebeen implemented.

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Smith, E., et H. M. Mclntyre. « Simulation and collective training - creating a total experience ». Aeronautical Journal 106, n^o 1057 (mars 2002) : 129–36. http://dx.doi.org/10.1017/s0001924000012860.

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AbstractThere is a popular misconception that synthetic training is only concerned with time spent in the simulator. If this were so, a training exercise which had focused on the simulation experience alone, might fail to provide the rich learning environment needed to maximise training opportunities and so fall short of expectations in terms of delivery of a complete training experience.This is particularly true when considering collective training for military aircrew; where all mission phases are equally important, and all roles and tasks must be carefully considered when assessing the training need. The training designers must create a scenario that meets the requirements of the total training audience (the collective) throughout all the mission phases; planning, briefing, flying (traditionally the key simulation event) and debriefing. This scenario must allow the trainees to become fully immersed and provide a ‘total experience’ in order for them to obtain maximum benefit from the synthetic training event.Maintenance of such an environment during the training process places an extra burden on those who are providing the training experience. As the number and mix of trainees participating in a synthetic exercise grows so too do the demands placed upon the exercise management team, the trainers and the assessors to provide a rich and rewarding training experience. Not only must these key personnel be carefully selected, their needs must also be taken into account during the training design process. This will help to ensure that transformation of data to information and information flow is optimised for all participants.Recent experience in mission training via distributed simulation has shown that greater training opportunities can be afforded if the training designers address the needs of all the above. Using these experiences as reference points, this paper will discuss synthetic training issues along with the expectations of the trainees and the training providers and suggest some guidelines for creating a total training experience.

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Wiland, P., A. Blauvelt, L. Lemke, O. Von Richter, A. Balfour, F. Furlan et N. Gaylis. « AB0208 DO LOW CONCENTRATIONS OF CITRATE IN AN ADALIMUMAB FORMULATION IMPACT THE INCIDENCE AND/OR INTENSITY OF INJECTION SITE PAIN ? DATA FROM PHASE I AND III STUDIES ASSESSING THE LOCAL TOLERANCE OF GP2017 (ADALIMUMAB BIOSIMILAR, SDZ-ADL) IN HEALTHY VOLUNTEERS, RHEUMATOID ARTHRITIS, AND PSORIASIS PATIENTS ». Annals of the Rheumatic Diseases 80, Suppl 1 (19 mai 2021) : 1130–31. http://dx.doi.org/10.1136/annrheumdis-2021-eular.1045.

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Background:Adalimumab (ADL) is typically self-administered every 2 weeks (W) as a subcutaneous (s.c.) injection by patients (pts) for diverse indications, including rheumatoid arthritis (RA), psoriatic arthritis (PsA), and psoriasis (PsO). Conflicting evaluations of local tolerance to formulations containing citrate buffer have created insecurities among health care professionals and pts.1,2Objectives:To evaluate local tolerance of SDZ-ADL (GP2017), a biosimilar ADL with low citrate concentration (1.2 mM),3 in 466 healthy volunteers (HV) and 408 pts (RA: 177 and PsO: 231 including PsA: 52) from four phase I pharmacokinetic (PK) and two phase III confirmatory studies.Methods:HV evaluated their injection site pain (ISP) using a Visual Analogue Scale (VAS) of 0–100 mm. HV received a single 40 mg/0.8 mL s.c. injection and pts received SDZ-ADL every 2W during 48–51W duration of study. Injection site reactions (ISR) as well as adverse events (AEs) were assessed by investigators during the clinical studies. Details of study designs have been reported previously.4–7Results:Overall, 456 (97.9%) HV experienced no ISR. Ten HV experienced ISR. These were mostly of mild intensity; only 1 (0.2%) had an ISR of moderate intensity. 96.6% of HV experienced no pain (VAS score 0–4 mm)8 at 1-hour post-dose (Figure 1). In the phase III studies, a low number of ISR/ISP events were observed, which decreased during the course of study. Detailed results are provided in Table 1. No ISR/ISP led to treatment or study discontinuation in any study.Conclusion:The proportion of HV and pts experiencing ISR and ISP after administration of SDZ-ADL was low, with no events leading to treatment or study discontinuation. These results call into question the clinical impact of citrate and its concentration in ADL formulations on the incidence and intensity of ISP.References:[1]Nash et al. Rheumatol Ther. 2016;3:257–70.[2]NHS. Regional medicines optimisation committee briefing, best value biologicals: adalimumab update 6. July 2019. https://www.sps.nhs.uk/wp-content/uploads/2019/07/Adalimumab-RMOC-Briefing-6.pdf.[3]https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/761071lbl.pdf.[4]Blauvelt A, et al. Br J Dermatol. 2018;179:623–31.[5]Wiland P, et al. BioDrugs 2020;34:809–23.[6]Richter OV, et al. Expert Opin Biol Ther. 2019;19:1057–64.[7]Richter OV, et al. Expert Opin Biol Ther. 2019;19:1075–83.[8]Hawker GA, et al. Arthritis Care Res. 2011;63:240–52.Figure 1.Proportion of HV with ISP in phase I PK studiesTable 1.ISP and ISR results from phase I PK and phase III confirmatory studiesPhase I PK studiesStudy101(N=73)102(N=108)103(N=178)104(N=107)Pooled studies (N=466)VAS scores (mm) at 1-hour post-doseMean (SD)0.89 (2.07)0.07 (0.52)1.03 (1.71)1.03 (2.49)0.79 (1.84)Median00100ISR scores at 1-hour post-dose, n (%)None73 (100)106 (98.2)178 (100)99 (92.5)456 (97.9)Mild0 (0)1 (0.9)0 (0)8 (7.5)9 (1.9)Moderate0 (0)1 (0.9)0 (0)0 (0)1 (0.2)Phase III confirmatory studiesADACCESS5* (PsO and PsA pts)ADMYRA6* (RA pts)W0–17 (N=231)W0–51 (N=168; including pts re-randomised to continue SDZ-ADL after W17)W0–24 (N=177)W0–48 (N=177; all pts continued SDZ-ADL after W24)DosageInduction 80 mg W0, then 40 mg EoW s.c.40 mg EoW s.c.40 mg EoW s.c.40 mg EoW s.c.Study duration, W17512448AEs - ISR, n (%), events15 (6.5), 349 (5.4), 267 (4.0), 117 (4.0), 12Mild14 (6.1), 309 (5.4), 267 (4.0), 117 (4.0), 12Moderate1 (0.4), 4000AEs - ISP (reported as ISR), n (%)3 (1.3)1 (0.6)2 (1.1)2 (1.1)*ADACCESS and ADMYRA were switch studies, therefore, only pts exposed to SDZ-ADL throughout the study period are included here. EoW, every other week, N, number of HV or ptsDisclosure of Interests:Piotr Wiland Speakers bureau: Celltrion, Celgene, Eli Lilly, Novartis, Pfizer, Sandoz, Sanofi-Aventis, Consultant of: Celltrion, Celgene, Eli Lilly, Novartis, Pfizer, Sandoz, Sanofi-Aventis, Andrew Blauvelt Speakers bureau: AbbVie, Almirall, Arena, Athenex, Boehringer Ingelheim, Bristol-Myers Squibb, Dermavant, Eli Lilly and Company, Evommune, Forte, Galderma, Incyte, Janssen, Leo, Novartis, Pfizer, Rapt, Regeneron, Sandoz, Sanofi Genzyme, Sun Pharma, and UCB Pharma., Consultant of: AbbVie, Almirall, Arena, Athenex, Boehringer Ingelheim, Bristol-Myers Squibb, Dermavant, Eli Lilly and Company, Evommune, Forte, Galderma, Incyte, Janssen, Leo, Novartis, Pfizer, Rapt, Regeneron, Sandoz, Sanofi Genzyme, Sun Pharma, and UCB Pharma., Lena Lemke Employee of: Hexal AG, Oliver von Richter Employee of: Hexal AG, Alison Balfour Employee of: Hexal AG, Fabricio Furlan Employee of: Hexal AG, Norman Gaylis: None declared

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Brodowski, Jan, et Małgorzata Winiarska-Brodowska. « Państwa Kaukazu Południowego w wypowiedziach rzeczniczki prasowej Ministerstwa Spraw Zagranicznych Federacji Rosyjskiej ». Politeja 19, n^o 3(78) (24 novembre 2022) : 35–52. http://dx.doi.org/10.12797/politeja.19.2022.78.03.

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STATES OF THE SOUTH CAUCASUS IN THE STATEMENTS OF THE PRESS SPOKESWOMAN OF THE MINISTRY OF FOREIGN AFFAIRS OF THE RUSSIAN FEDERATION The Russian Federation currently plays a key role in the South Caucasus region. The aim of the article is to attempt to answer the question of how and to what extent Armenia, Azerbaijan and Georgia are present in the message presented by the Russian Ministry of Foreign Affairs. The briefings of the spokesperson of the Ministry of Foreign Affairs of the Russian Federation, which took place between July and December 2020, i.e. during events important for the region, were subject to quantitative and qualitative analysis. The South Caucasus, in the light of the spokesperson’s statements, is not a priority for the Russian diplomatic service, but as a result of the foreign policy it is creating, it appears relatively regularly. The key topics in the analyzed period include the COVID-19 pandemic and the new phase of the conflict over Nagorno-Karabakh. The thought-out narrative of the Russian Ministry of Foreign Affairs, which served to shape the perception of the region and strengthen the Russian position, should be emphasized.

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Scanlon, James V., Benjamin P. Exter, Michael Steinberg et Courtney I. Jarvis. « Ustekinumab : Treatment of Adult Moderate-to-Severe Chronic Plaque Psoriasis ». Annals of Pharmacotherapy 43, n^o 9 (11 août 2009) : 1456–65. http://dx.doi.org/10.1345/aph.1m151.

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Objective: To systematically review the pharmacology, pharmacokinetics, clinical efficacy, and safety profile of ustekinumab to inform pharmacists and other healthcare professionals of this new biologic therapy for psoriasis. Data Sources: A search of PubMed/MEDLINE, EMBASE, and International Pharmaceutical Abstracts was performed through July 2009, limited to publications in English, using the search terms CNTO-1275, ustekinumab, interleukin-12, interleukin-23, and/or psoriasis to identify literature sources. References from the retrieved articles were also evaluated to identify relevant literature. An abstract from a Congress of the European Academy of Dermatology and Venereology and unpublished Phase 3 clinical trials in progress (using www.clinicaltrials.gov ) were also reviewed. The Food and Drug Administration, European Medicines Agency, and Health Canada Web sites were used to retrieve product monographs, regulatory guidances, and advisory committee briefing packets. Study Selection and Data Extraction: All available studies relevant to the pharmacology, pharmacokinetics, and clinical safety/efficacy of ustekinumab for the treatment of psoriasis were included, with preference for human data. Data Synthesis: Ustekinumab, an anti-interleukin-12/23 monoclonal antibody, achieved the primary endpoint of 75% reduction in the Psoriasis Area and Severity Index score in a large proportion of patients in the Phase 3 PHOENIX trials. Commensurate improvements were also seen in the Physician's Global Assessment and Dermatology Life Quality Index scores. These efficacy results were reproduced in the ACCEPT trial, demonstrating superiority of ustekinumab to etanercept. The frequency of adverse events was similar between ustekinumab and placebo; common adverse events reported included nasopharyngitis, upper respiratory tract infection, headache, arthralgia, cough, and injection site reactions. Phase 3 studies indicate that the optimal dosing appears to be 45 mg for patients weighing less than 100 kg or 90 mg for patients weighing more than 100 kg, with both doses administered subcutaneously. In these studies, the second dose was given 4 weeks after the first and then every 8–12 weeks thereafter, based upon response. Conclusions: Ustekinumab, a promising new therapy, reduces the extent and severity of psoriasis and was well tolerated in clinical trials. Ongoing clinical trials will allow clinicians to further assess the efficacy/safety profile of this novel biologic.

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Bruno, R., J. Lu, Y. Sun et L. Claret. « Simulation of survival with first- and second-line non-small cell lung cancer (NSCLC) therapy using a public domain drug-disease modeling framework ». Journal of Clinical Oncology 27, n^o 15_suppl (20 mai 2009) : 8087. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.8087.

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8087 Background: Modeling and simulation approaches are advocated to support drug development decisions. In this study, we evaluated the ability of a drug-disease model recently developed by scientists at the FDA using data from pivotal studies in NSCLC (Wang et al. http://www.fda.gov/ohrms/dockets/ac/08/briefing/2008–4351b1–00-index.htm ) to simulate survival and tumor response for approved therapies in NSCLC. Methods: The modeling framework comprises a longitudinal tumor size model and a survival model relating change in tumor size at first visit (week 8) and patient characteristics (tumor size and ECOG performance status at baseline) to survival time. The tumor size and survival models were used to simulate change in tumor size at first visit and expected survival in the carboplatin/paclitaxel (CP) arm of the E4599 study (first-line NSCLC, N Eng J Med. 2006;355:2542–2550) and in the erlotinib arm in the BR.21 study (second-line NSCLC, N Eng J Med. 2005;353:123–132). The predictive distributions (95% prediction interval [PI]) of survival times were derived from multiple replicates (500) of 400 CP patients and 500 erlotinib patients with similar characteristics to patients in the original studies. Results: There was a high level of concordance between the results of the simulation and the observed results in the two arms, indicating that the modeling framework successfully predicted survival and tumor response. Expected median survival was 9.8 (95% PI, 8.2–11.8) months (vs 10.3 months observed) for the CP arm and 6.8 (95% PI, 5.3–8.9) months (vs 6.7 months observed) for the erlotinib arm. The median change in relative tumor size from baseline at week 8 predicted by the model was 12.1% for the CP arm and 9.5% for the erlotinib arm. Conclusions: The modeling framework can be used to perform simulations of survival of approved treatments. These results suggest that the model could be used to simulate survival for investigational treatments based on tumor shrinkage data observed in early clinical studies (e.g. phase II) to support end-of-phase II decisions and the design of phase III studies. [Table: see text]

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Katz, Eva G., Pauline McNulty, Bennett Levitan, Patricia Treichler, Jadwiga Martynowicz et Carol Jamieson. « U.S. Food and Drug Administration’s Patient-Focused Drug Development Initiative : Experience with Integration of Patient-Experience Data in a New Drug Application for Esketamine Nasal Spray Plus a Newly Initiated Oral Antidepressant for Treatment-Resistant Depression ». Therapeutic Innovation & ; Regulatory Science 56, n^o 1 (8 octobre 2021) : 38–46. http://dx.doi.org/10.1007/s43441-021-00340-6.

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AbstractThe Patient-Focused Drug Development initiative of the U.S. Food and Drug Administration (FDA) aims to ensure that the patient experience of disease and treatment is an integral component of the drug development process. The 21st Century Cures Act and Prescription Drug User Fee Act (PDUFA) VI require the FDA to publicly report the type of patient-experience data reviewed in a new drug application (NDA) to inform regulatory decision-making. This report describes a recent approach adopted at Janssen of integrating patient-experience data into the NDA for esketamine (SPRAVATO®) nasal spray with a newly initiated oral antidepressant (esketamine + AD) for treatment-resistant depression. During the development of esketamine + AD, patient-experience data were collected using several patient-reported outcomes, including the Sheehan Disability Scale and 9-item Patient Health Questionnaire (PHQ-9). Additionally, a patient-preference study assessed the relative importance of benefits and harms that patients allocated to different attributes of treatment. Preferences were collected from patients enrolled in phase 3 esketamine trials and from an online panel of primarily ketamine-naive patients. Patient-experience data were integrated into the esketamine NDA, the FDA advisory committee meeting briefing document, and the Sponsor’s presentation. The FDA acknowledged reviewing the patient-experience data and determined that they supported esketamine + AD for treatment-resistant depression. This report highlights the importance of integrating patient-experience methods early in drug development, their impact on assessing patient-relevant benefits and risks, and how they can help improve clinical program design.

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Lahiri, Ramyajit, Imran Khan et Sudip Banerjee. « Use of Ultrasonography vs Clinical Assessment to Confirm Endotracheal Tube Placement by Emergency Physicians ». Galore International Journal of Health Sciences and Research 8, n^o 1 (30 janvier 2023) : 20–38. http://dx.doi.org/10.52403/gijhsr.20230104.

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Airway management skills are indispensable for an emergency physician. Unrecognized airway accidents such as oesophageal intubation tend to occur more in emergency room, where it is reported as 6%-16%. Various studies have compared methods used for distinguishing between endotracheal and oesophageal placement of the tube. The aim of this study is to assess the diagnostic accuracy and timeliness of ultrasonography by static method only for identification of Endo tracheal tube (ET Tube) placement in trachea in an emergency setting vs existing clinical methods. This prospective study was carried out in the emergency room from March 2020 till end of October 2022. The ultrasonography was performed 120 emergency patients only after the intubation had been completed i.e. static phase. A linear probe was used over neck to identify the predefined signs of ET intubation. Residents who perform ultrasound examination fill a form after assessment of each patient. It was found that Tracheal Intubation-USG Sensitivity was 99.1, Specificity was 91.7, Positive Predictive Value: 99.1, Negative Predictive Value was 91.7 and Accuracy was 98.3%. Ultrasonography can be used as an adjunct tool to verify the ETT position by Emergency Physicians which can be performed easily after a briefing or short-course training. This study demonstrates that US imaging has a high diagnostic accuracy to immediately confirm proper ETT placement post-intubation in an emergency setup. Therefore, it seems that ultrasonography using static technique only is a proper screening tool in determining endotracheal tube placement. Keywords: Endotracheal intubation, emergency, ultrasonography, USG Sensitivity

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Mardewanti, Endah. « PENGEMBANGAN PERANGKAT PEMBELAJARAN DENGAN PENDEKATAN CTL MENGGUNAKAN MODEL KOOPERATIF GROUP INVESTIGATION UNTUK MELATIHKAN KETERAMPILAN BERPIKIR KRITIS SISWA SMA PADA MATERI FLUIDA STATIS ». JPPS (Jurnal Penelitian Pendidikan Sains) 6, n^o 1 (31 janvier 2017) : 1246. http://dx.doi.org/10.26740/jpps.v6n1.p1246-1254.

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This study aims to accustome the ability of critical thinking skills of students who managed CTL approach using model Group Investigation. This study was conducted in two phases, the preparation phase which aims to develop learning package and the second phases of the trail of the device. Learning package developed in the form of lesson plan (RPP), Students worksheet (LKS), text books (BAS), and critical thingking skills test (TBK). Critical thinking skills are trained include formulating the problem, provide argument, analize and conclude. The device was developed with the development step of Borg and Gall, then proceed with the trial in the classroom by using pretest-posttest design. Data collected by expert judgement, observation, testing, and legibility BAS were collected using techniques close procedure. The collected data were then analized using descriptive analysis. Results of data analysis obtained as follows the quality of learning package developed by expert declared valid by validator. extremely high level of legibility and easy to understand, RPP achieve excellent, student activity that stand out is formulating a problem; student activity that stands out is formulating a problem; obstades that occur in the learning process is that students are not familiar investigations, thus requiring a briefing before hand. Critical thinking skills of students in the high category. Students' response to the lessons learned, so of data analysis can be concluded that the learning package by using CTL approach GI type cooperative model in the static fluid material can be used to train students' critical thinking skill Penelitian ini bertujuan untuk menghasilkan perangkat pembelajaran yang dapat digunakan melatihkan keterampilan berpikir kritis siswa yang dikelola dengan pendekatan CTL menggunakan model Group Investigation. Penelitian ini dilaksanakan dalam dua tahap, yaitu tahap persiapan yang bertujuan mengembangkan perangkat pembelajaran dan tahap kedua tahap uji coba perangkat. Perangkat pembelajaran yang dikembangkan berupa Rencana Pelaksanaan Pembelajaran (RPP), Lembar Kerja Siswa (LKS), Buku Ajar Siswa (BAS), dan tes Keterampilan Berpikir Kritis (KBK). Keterampilan berpikir kritis yang dilatihkan meliputi merumuskan masalah, memberikan argumen, menganalisis, dan menyimpulkan. Perangkat dikembangkan dengan langkah-langkah pengembangan dari Borg and Gall, kemudian dilanjutkan dengan uji coba di SMA Plus Sabilur Rosyad di kelas X-IPA1 dan X-IPA2 dengan menggunakan rancangan pretest-postest design. Data dikumpul berdasarkan penilaian validator, observasi, tes, dan keterbacaan BAS yang dikumpul dengan menggunakan teknik close procedure. Data yang terkumpul kemudian dianalisis menggunakan analisis data secara deskriptif. Hasil analisis data diperoleh sebagai berikut: kualitas perangkat pembelajaran yang dikembangkan dinyatakan valid oleh pakar/validator; tingkat keterbacaan BAS sangat tinggi dan mudah dipahami; RPP mencapai keterlaksanaan yang sangat baik; aktivitas siswa yang menonjol adalah merumuskan masalah; kendala yang terjadi dalam proses pembelajaran adalah siswa belum terbiasa melakukan penyelidikan, sehingga membutuhkan pengarahan terlebih dahulu. Keterampilan berpikir kritis siswa masuk dalam kategori tinggi. Respon siswa terhadap pembelajaran baik, sehingga dari hasil analisis data, dapat disimpulkan bahwa perangkat pembelajaran dengan pendekatan CTL menggunakan model kooperatif Group Investigation pada materi fluida statis dapat digunakan untuk melatihkan keterampilan berpikir kritis siswa.

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Bradshaw, Andy, Martina Santarelli, Assem M. Khamis, Kathryn Sartain, Miriam Johnson, Jason Boland, Mark Pearson et Fliss E. M. Murtagh. « Implementing person-centred outcome measures (PCOMs) into routine palliative care : A protocol for a mixed-methods process evaluation of The RESOLVE PCOM Implementation Strategy ». BMJ Open 11, n^o 9 (septembre 2021) : e051904. http://dx.doi.org/10.1136/bmjopen-2021-051904.

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IntroductionPerson-centred outcome measures improve quality of care and patient outcomes but are used inconsistently in palliative care practice. To address this implementation gap, we developed the ‘RESOLVE Implementation Strategy’. This protocol describes a process evaluation to explore mechanisms through which this strategy does, or does not, support the implementation of outcome measures in routine palliative care practice.Methods and analysisMultistrand, mixed-methods process evaluation. Strand one will collect routine outcomes data (palliative Phase of Illness, Integrated Palliative care Outcomes Scale, Australia-modified Karnofsky Performance Status) to map the changes in use of outcome measures over 12 months (July 2021–July 2022). Strand two will collect survey data over the same 12-month period to explore how professionals’ understandings of, skills in using and ability to build organisational practices around, outcome measures change over time. Strand three will collect interview data to understand the mechanisms underpinning/affecting our implementation strategy. Thematic framework analysis and descriptive statistics will be used to analyse qualitative and quantitative data, respectively.Ethics and disseminationFor strand one, ethical approval has been obtained (Cambridge REC, REF: 20/EE/0188). For strands two and three, ethical approval has been obtained from Hull York Medical School ethics committee (2105). Tailored feedback of study findings will be provided to participating sites. Abstracts and papers will be submitted to national/international conferences and peer-reviewed journals. Lay and policy briefings and newsletters will be shared through patient and public involvement and project networks, plus via the project website.

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Kumaji, Syam S., et Abubakar Sidik Katili. « PEMBERDAYAAN MASYARAKAT PETANI JAGUNG (Zea mays L.) MELALUI PENGEMBANGAN KELOMPOK USAHA BERSAMA (KUBE) MELATI ». JURNAL PENGABDIAN KEPADA MASYARAKAT 25, n^o 1 (23 août 2019) : 36. http://dx.doi.org/10.24114/jpkm.v25i1.13937.

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Implementasi program pemberdayaan masyarakat melalui pengolahan jagung melalui kegiatan KKN PPM tahun 2019 dilaksanakan di desa Ilohungayo. Adapun tujuan dari program ini adalah menyerap tenaga kerja, menambah pendapatan masyarakat melalui Usaha Kecil Menengah, meningkatkan kreativitas dan inovasi lokal yang dapat dijadikan produk khas daerah Gorontalo dan meningkatkan nilai jual komoditas Jagung di Desa Ilohungayo, Kecamatan Batudaa Kabupaten Gorontalo. Solusi yang dapat dilakukan yaitu melalui pengolahan bahan mentah jagung menjadi produk yang lezat, bergizi dan disukai serta bisa menjadi produk khas daerah yang dapat bersaing dengan daerah lain. Adapun metode yang digunakan dalam program ini adalah metode penyuluhan dan pelatihan. Program ini bekerja sama dengan KUBE Melati Desa Ilohungayo sebagai mitra dalam pusat pengolahan jagung menjadi stik jagung dan Plaza Amanda Jaya Gorontalo sebagai mitra dalam proses pemasaran produk cemilan. Alur kegiatan meliputi tahap persiapan berupa observasi ke dinas instansi terkait dan pembekalan mahasiswa KKN-PPM. Kemudian tahap pelaksanaan, yaitu penyuluhan dan pelatihan pada masyarakat di 4 dusun yakni Dusun Ilito, Ilito Barat, Hungayo, Hungayo Timur, dan Hungayo Selatan yang berpusat di Desa Ilohungayo. Kata Kunci: Pemberdayaan, Produk, Jagung. Abstract The Implementation of a community service program through the processing of corn through the community service program 2019 is conducted at Ilohungayo Village. This program aims to absorb labors, add community income through small and medium enterprises, improve creativity and local innovation that can be the typical products from Gorontalo and increase the selling value of corn commodities at Ilohungayo Village, Batudaa Sub-district, Gorontalo District. The solution that can be done is through the processing of the raw corn into the delicious, nutritious and preferredproduct as well as to be the typical local product that can compete with products from other areas. The methods used in this program are counseling and training. This program cooperates with Melati joint venture at Ilohungayo village as a partner in the center of corn processing into corn stick as well as Plaza Amanda Jaya Gorontalo as a partner in the marketing process of the snack products. The flow of activities includes a preparation phase in the form of observation to the related institutions and students’ Community Service Program briefing. The next phase is implementation which is counseling and training to the community at 4 orchards; Ilito Orchard, Ilito Barat, Hungayo, Hungayo Timur, and Hungayo Selatan which centered on Ilohungayo Village. Keywords: Empowerment, Product, Corn.

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Kotobuki, Masashi, Qilin Gu, Lei Zhang et John Wang. « Ceramic-Polymer Composite Membranes for Water and Wastewater Treatment : Bridging the Big Gap between Ceramics and Polymers ». Molecules 26, n^o 11 (1 juin 2021) : 3331. http://dx.doi.org/10.3390/molecules26113331.

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Clean water supply is an essential element for the entire sustainable human society, and the economic and technology development. Membrane filtration for water and wastewater treatments is the premier choice due to its high energy efficiency and effectiveness, where the separation is performed by passing water molecules through purposely tuned pores of membranes selectively without phase change and additional chemicals. Ceramics and polymers are two main candidate materials for membranes, where the majority has been made of polymeric materials, due to the low cost, easy processing, and tunability in pore configurations. In contrast, ceramic membranes have much better performance, extra-long service life, mechanical robustness, and high thermal and chemical stabilities, and they have also been applied in gas, petrochemical, food-beverage, and pharmaceutical industries, where most of polymeric membranes cannot perform properly. However, one of the main drawbacks of ceramic membranes is the high manufacturing cost, which is about three to five times higher than that of common polymeric types. To fill the large gap between the competing ceramic and polymeric membranes, one apparent solution is to develop a ceramic-polymer composite type. Indeed, the properly engineered ceramic-polymer composite membranes are able to integrate the advantages of both ceramic and polymeric materials together, providing improvement in membrane performance for efficient separation, raised life span and additional functionalities. In this overview, we first thoroughly examine three types of ceramic-polymer composite membranes, (i) ceramics in polymer membranes (nanocomposite membranes), (ii) thin film nanocomposite (TFN) membranes, and (iii) ceramic-supported polymer membranes. In the past decade, great progress has been made in improving the compatibility between ceramics and polymers, while the synergy between them has been among the main pursuits, especially in the development of the high performing nanocomposite membranes for water and wastewater treatment at lowered manufacturing cost. By looking into strategies to improve the compatibility among ceramic and polymeric components, we will conclude with briefing on the perspectives and challenges for the future development of the composite membranes.

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Thompson, Jennifer L. « Carfilzomib : A Second-Generation Proteasome Inhibitor for the Treatment of Relapsed and Refractory Multiple Myeloma ». Annals of Pharmacotherapy 47, n^o 1 (janvier 2013) : 56–62. http://dx.doi.org/10.1345/aph.1r561.

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OBJECTIVE To review and summarize data on carfilzomib, which was approved by the Food and Drug Administration (FDA) in July 2012 for the treatment of patients with relapsed and refractory multiple myeloma (MM) who received prior bortezomib and thalidomide or lenalidomide. DATA SOURCES A literature search through PubMed was conducted through October 2012 using the terms carfilzomib, PR-171, proteasome inhibitor (PI), and MM. Data were also obtained through the American Society of Clinical Oncology and American Society of Hematology abstracts and FDA briefing documents. STUDY SELECTION AND DATA EXTRACTION The literature search was limited to human studies published in English. Priority was placed on trials of carfilzomib in relapsed and refractory MM. DATA SYNTHESIS Carfilzomib is a new PI that differs in pharmacology and pharmacokinetics from bortezomib, the first-in-class PI. The FDA approval was based on efficacy data from a Phase 2 study of carfilzomib in patients with relapsed and refractory MM (n = 266). All patients had received prior bortezomib and 80% were refractory or intolerant to both bortezomib and lenalidomide. Patients were treated with intravenous carfilzomib 20 mg/m2 (cycle 1) followed by 27 mg/m2 (cycles ≥2) on days 1, 2, 8, 9, 15, and 16 of each 28-day cycle. The overall response rate was 23.7% (18.7–29.4), with a median duration of response of 7.8 (5.6–9.2) months. Safety data from an integrated analysis reported thrombocytopenia, anemia, fatigue, nausea, and diarrhea as the most common adverse events, with minimal dose-limiting neutropenia or peripheral neuropathy (PN) (n = 526). The incidence of grade 3 or higher thrombocytopenia was 24.9%, while that of neutropenia was 11.9%, and the incidence of all grades of treatment-emergent PN was 13%. CONCLUSIONS Carfilzomib is a safe and effective new treatment option for patients with relapsed MM refractory to bortezomib and thalidomide or lenalidomide. Randomized head-to-head trials with bortezomib will assist in formulary and treatment decisions in the context of PIs as a drug class.

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Salimi, Yuszda K., et Citron S. Payu. « PEMBERDAYAAN MASYARAKAT DALAM PENINGKATAN NILAI TAMBAH PENGOLAHAN LIMBAH KULIT PISANG (MUSA PARADISIACA) MENJADI TEPUNG UNTUK MENINGKATKAN PENDAPATAN MASYARAKAT ». JURNAL PENGABDIAN KEPADA MASYARAKAT 25, n^o 1 (23 août 2019) : 42. http://dx.doi.org/10.24114/jpkm.v25i1.13938.

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Progam KKN PPM Desa Barakati Kecamatan Batudaa Kabupaten Gorontalo dilaksanakan dengan tujuan meningkatkan pendapatan masyarakat melalui pengolahan limbah Kulit Pisang. Upaya yang dilakukan adalah melalui pengolahan Kulit Pisang menjadi Tepung yang berkualitas serta memiliki nilai jual yang berkompeten dipasaran. Adapun metode yang digunakan dalam program ini adalah metode penyuluhan, pelatihan, teori dan praktek. Program ini bekerja sama dengan kelompok masyarakat UP. FMA Desa Barakati sebagai mitra dalam pusat pengolahan Kulit Pisang menjadi Tepung. Alur kegiatan meliputi tahap persiapan berupa observasi ke dinas instansi terkait dan pembekalan mahasiswa KKN-PPM. Kemudian tahap pelaksanaan, yaitu penyuluhan dan pelatihan pada masyarakat di 4 dusun yakni Dusun I Hungayo, Dusun II Botuhuwayo, Dusun III Hutamela dan Dusun IV Bontula, yang berpusat di UP-FMA Desa Barakati. Adapun diantara hasil yang telah dicapai adalah 1) meingkatnya pengetahuan dan keterampilan kelompok masyarakat sasaran dalam pengolahan limbah kulit pisang, 2) meningkatnya pendapatan kelompok sasaran sebagai akibat dari penjualan hasil produksi, 3) Mengurangi tingkat pengangguran di tingkat desa. Oleh karena itu program ini telah memberikan dampak positif bagi kelompok masyarakat sebagai sasaran, pemerintah desa setempat, tim dosen pelaksana dan mahasiswa peserta KKN PPM Tahun 2019. Kata Kunci : Pemberdayaan, Pengolahan, Kulit Pisang. AbstractThe community service at Barakati Village, Batudaa Sub-district, Gorontalo District is conducted to improve the community’s income through the processing of banana peel waste. The effort made is through the processing of banana peel into a quality and high selling flour. The methods used are counseling, training, theory,and practice. This program cooperates with a community group of UP. FMA Barakati village as a partner in the center of banana peel processing into flour. The flow of activities includes a preparation phase in the form of observation to the related institutions and students’ Community Service Program briefing. The next phase is implementation which is counseling and training to the community at 4 orchards; Orchard I Hungayo, Orchard II Botuhuwayu, Orchard III Hutamela and Orchard IV Bontula which centered on UP-FMA Barakati Village. The achieved results, among others, are: 1) the increase of knowledge and skill of targeted community group in processing banana peel waste, 2) the increase of targeted community’s income as a result of product sales, 3) decrease the level of unemployment within the village. Therefore, this program has shown a positive impact on the targeted community group, the local village government, the team of implementing lecturers and students who are participants of the community service program 2019. Keywords : Empowerment, Processing, Banana Peel.

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Goodman, William A. « 3D Printed and Additively Manufactured RoboSiC™ for Space, Cryogenic, Laser and Nuclear Environments ». International Symposium on Microelectronics 2018, n^o 1 (1 octobre 2018) : 000099–103. http://dx.doi.org/10.4071/2380-4505-2018.1.000099.

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Abstract Goodman Technologies has been directly responsive to, and focused on, 3D printing and additive manufacturing techniques, and what it takes to manufacture in zero-gravity. During a NASA Phase I SBIR project, using a small multi-printhead machine, we showed that it was possible to formulate and 3D print silicon carbide into shapes appropriate for lightweight mirrors and structures at the production rate of 1.2 square-meter/day. Gradient lattice coupons with feature sizes on the order of 0.8mm were printed and were easily machined to very fine tolerances, ten-thousandths of an inch by Coastline Optics in Camarillo, CA. To further elaborate on the list of achievements, in Phase I, Team GT demonstrated three different ceramization techniques for 3D printing low areal cost, ultra-lightweight Silicon Carbide (SiC) mirrors and structures, radiation shielding, and electronics, several of which could be employed in microgravity The Goodman Technologies briefing presented at 2017 Mirror Technology Days “3D Printed Silicon Carbide Scalable to Meter-Class Segments for Far-Infrared Surveyor: NASA Contract NNX17CM29P along with sample coupons resulted in extreme interest from both Government and the Contractor communities. Our materials, which we call RoboSiC™, is suited for many other applications including heat sinks and radiation shielding for space electronics, and we have already started to make the first parts for these applications. The successful Phase I project suggests that we will meet or exceed all NASA requirements for the primary mirror of a Far-IR Surveyor such as the Origins Space Telescope (OST) and have a high probability solution for the LUVOIR Surveyor in time for the 2020 Decadal Survey. Results indicate that printing on the ground will achieve an areal density of 7.75 kg/square-meter (~39% of a James Webb Space Telescope (JWST) beryllium segment), a cost to print of $60K/segment, and an optical surface that has nanometer-scale tolerances. Printing in the microgravity environment of space we have the potential to achieve an areal density of 1.0–2.0 kg/square meter (<10% of a JWST beryllium segment), with a cost to print of ~$10K/segment. The areal density is 2–15 times better than the NASA goal of 15 kg/square meter, and the costs are substantially better than the NASA goal of $100K/square meter. The encapsulated gradient lattice construction provides a uniform CTE throughout the part for dimensional stability, incredible specific stiffness, and the added benefit of cryo-damping. For the extreme wavefront control required by the Large UV/Optical/IR Surveyor (LUVOIR) the regularly spaced lattice construction should also provide deterministic mapping of any optical distortions directly to the regular actuator spacing of a deformable mirror (DM). Some of our processes will also allow for direct embedding of electronics for active structures and segments. Encapsulation of the lattice structures will allow for actively cooling with helium for unprecedented low emissivity and thermal control. Several decades of experience and testing with SiC have shown that our materials will survive, nay thrive in, the most extreme Space, Cryogenic, Laser and Nuclear Environments.

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Carpiuc, Kim, Khalid El Ouagari, Jennifer Stephens, Marc Botteman, WeiWei Feng et Richard C. Woodman. « Short-Term Cost Per Responder among New Tyrosine Kinase Inhibitors for Imatinib-Resistant CML in Chronic Phase (CML-CP) — Canada and Germany Perspectives. » Blood 110, n^o 11 (16 novembre 2007) : 4587. http://dx.doi.org/10.1182/blood.v110.11.4587.4587.

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Abstract BACKGROUND: For indications such as imatinib-resistant CML where data on durability of response or survival is still emerging, an alternative to modeling long-term cost-effectiveness is to perform a short-term analysis estimating average cost per responder based on cytogenetic responses, as the first 6–12 months have been shown to be a useful surrogate marker for treatment efficacy. This study incorporates cytogenetic response (MCyR or CCyR) with drug and adverse event (AE) costs to compare the 6-month cost per responder between dasatinib and nilotinib in patients with CML-CP. METHODS: The average cost per responder was estimated by dividing the 6-month cost of treatment with cytogenetic response. Total cost of treatment included drug costs only for the primary analysis, but adding the cost of managing grade 3/4 AEs in sensitivity analyses. Based on time to event information, AEs were assumed to occur within the first 6 months of treatment. As no head-to-head comparison studies for nilotinib and dasatinib exist, data were obtained from studies believed to have the most comparable patient populations and similar length of study follow-up. Data on dasatinib were obtained from the published dasatinib phase II START-C study and the dasatinib FDA Oncologic Drug Advisory Committee (ODAC) briefing document. Two alternative cost perspectives were taken representing two cost structures. Dasatinib daily drug cost (140 mg/day) was assumed at Can$150.94 and Germany €146.66. For nilotinib, data were obtained from the nilotinib phase II 120-day efficacy and safety update clinical study reports submitted for registration, with daily drug (800 mg/day) cost based upon price parity with 800 mg/day imatinib. The model was developed from a payer perspective considering direct medical costs only. RESULTS: Short-term (6-month) MCyR and CCyR rates for imatinib-resistant patients treated with 140 mg daily dasatinib were reported to be 31% and 22%. The corresponding numbers for 800 mg daily nilotinib were 51% and 31%, respectively. Primary cost drivers for AEs were myelosuppression events. Excluding the cost of AEs, the 6-month cost per MCyR was estimated to be Can$87,641 for dasatinib and Can$72,226 for nilotinib (Germany: €85,157 for dasatinib, €59,259 for nilotinib). The 6-month cost per CCyR was Can$123,480 for dasatinib, and Can$118,823 for nilotinib (Germany: €119,995 for dasatinib, €97,490 for nilotinib). Costs of treatment-related AEs for dasatinib and nilotinib were estimated at Can$10,429 and Can$4,861, respectively. Including AE costs in sensitivity analyses increased the cost per responder by 39% for dasatinib (7–17% for Germany) and by 13% for nilotinib (6–7% for Germany). CONCLUSION: The average 6-month cost per MCyR and CCyR is lower for nilotinib compared to dasatinib when daily drug costs for nilotinib are assumed at price parity with imatinib 800mg regardless of whether AEs are included. The analysis incorporating AEs may be conservative considering only severe grade 3/4 AEs were included and indirect costs were not addressed. In the absence of head-to-head studies, these analyses should be updated as longer follow-up data become available, with ideal analyses using total costs and cytogenetic response rates at 1 year of follow-up, as well as expansion into long-term cost effectiveness analyses.

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Blayney, Douglas W., Ene Ette, Stephan Ogenstad, Yuankai Shi, Lihua Du, Kenneth Lloyd, Lan Huang et Ramon Mohanlal. « Plinabulin, a Novel Small Molecule in Development for Chemotherapy-Induced-Neutropenia (CIN) Prevention, Mobilizes CD34+ Cells through a Mechanism of Action (MoA) Different from G-CSF and from CXCR4 Inhibition ». Blood 132, Supplement 1 (29 novembre 2018) : 2068. http://dx.doi.org/10.1182/blood-2018-99-113569.

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Abstract Introduction: Hematopoietic cell transplantation (HCT) involves the transplantation of hematopoietic stem and progenitor cells (HSCs/HPCs) from autologous or histocompatible allogeneic donors. HCT restores bone marrow function after conditioning, high dose chemotherapy (Bendall, Cytokine & Growth Factor Reviews 2014). G-CSF, which prevents CIN, is also used to mobilize HSCs/HPCs (CD34+ cells) prior to HCT. Plinabulin (Plin), a small molecule with immune-enhancing anticancer activity, is under clinical development for cancer treatment and CIN prevention. Plin has anticancer activity in lung cancer (NSCLC) patients (pts) (Mohanlal, ASCO-SITC 2017), and patient-derived multiple myeloma (MM) cell lines (Singh, Blood 2011). Single-dose-per-cycle Plin and pegfilgrastim (Peg) are equally effective for the prevention of Docetaxel (Doc)-induced grade 4 Neutropenia in NSCLC pts (Blayney; ASCO 2018; ASH 2016). Plin has a different MoA vs Peg; Plin acts through reversal of Doc-induced hematopoietic stem cell (LSK) maturation arrest in mouse bone marrow (Lloyd, AACR 2016) and increases neutrophil (N) demargination in pts (Blayney, SLB/IEIIS 2018). In contrast to Peg, Plin causes minimal bone pain, Plin ameliorates Doc-induced thrombocytopenia, and Plin does not increase N-to-Lymphocyte ratio (NLR) to immunosuppressive values of >5 in NSCLC pts (Blayney, IASCL 2018, ESMO 2018). Plerixafor (Pler), a chemokine receptor 4 (CXCR4) antagonist, inhibits CXCR4/SDF-1 binding facilitating CD34+ cell mobilization. Plinabulin does not inhibit CXCR4 (19% inhibition at 10μM Plin) in-vitro, thus Plin and Pler also have different MoAs. Although both G-CSF and Pler are effective in mobilizing CD34+ cells, up to 40% of pts fail to adequately mobilize HSCs/HPCs with G-CSF, or Pler combined with G-CSF (Jantunen, Eur J Hematol 2010). Predominantly due to high cost, Pler is not widely used. Since Plin has a different MoA vs G-CSF or Pler, Plin could be a valuable option for the mobilization of CD34+ cells prior to HCT, in particular if CD34+ response to G-CSF or G-CSF/Pler is inadequate. Peak CD34+ blood cell counts with G-CSF was ~6 cells/μL (Zarxio FDA Briefing Book, 2015). In a CIN phase 2 trial in NSCLC pts, designed to study Plin's efficacy to prevent Doc CIN, we also prospectively measured CD34+ peripheral blood cell count to assess whether Plin mobilized HSCs/HPCs. Method: In study BPI-2358-105 (NCT03102606), NSCLC pts received 75 mg/m2 Doc with Plin at 5 mg/m2 (n=14), 10 mg/m2 (n=13) or 20 mg/m2 (n=14) on D1. Blood CD34+ cell counts were measured before (D0) and after (D 2,6,8 of Cycle 1 and D1 of Cycle2) Doc+Plin administration. CD34+ measurements were obtained in at least 9 pts on both D0 and D8 for each Plin dose. No blood draws for CD34+ cells were taken after D8. Results. Predose D0 CD34+ cell counts were comparable among Plin groups (p<0.8; figure 1, left). D8 was the earliest time point that showed increase in CD34+ cell counts. No blood draws for CD34+ after D8 in Cycle 1 was taken. Blood CD34+ cell count (Figure 1, right) on D8 had increased dose-dependently with Plin (p<0.0004; Jonckheere Terpstra test for dose-response). Change in CD34+ cell count from D0 was also increased dose-dependently on D8 (P<0.0004). In the 5 mg/m2 Plin group, median CD34+ cell counts on D8 had slightly declined, presumably due to myelosuppression with concomitant Doc. The frequency of pts with an increase in blood CD34+ cell count on D8 vs D0 was 89%, 60% and 50% in the 20, 10 and 5 mg/m2 Plin groups, respectively (P<0.0001 for dose response). Doc dose intensity was similar in all Plin dose arms. Conclusion: Plin (20 mg/m2), an agent with anticancer activity for MM and NSCLC, mobilized CD34+ cells to clinically relevant blood counts in the vast majority of pts, through a MoA different from G-CSF or Pler. The CD34+ cell counts with Plin in the HCT setting is likely to be higher than observed in this CIN study, since concomitant myelosuppressive Doc was used with Plin. Furthermore CD34+ cell counts after D8 are likely to increase further with Plin, but this was not measured in this study. Based on current data evidence, Plin has the potential to become a viable option for the mobilization of CD34+ cells from the bone marrow prior to HCT, in particular in pts failing to respond to G-CSF or G-CSF/Pler. Disclosures No relevant conflicts of interest to declare.

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Minh, Pham Thi, Bui Thi Tuyet, Tran Thi Thu Thao et Le Thi Thu Hang. « Application of ensemble Kalman filter in WRF model to forecast rainfall on monsoon onset period in South Vietnam ». VIETNAM JOURNAL OF EARTH SCIENCES 40, n^o 4 (18 septembre 2018) : 367–94. http://dx.doi.org/10.15625/0866-7187/40/4/13134.

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This paper presents some results of rainfall forecast in the monsoon onset period in South Vietnam, with the use of ensemble Kalman filter to assimilate observation data into the initial field of the model. The study of rainfall forecasts are experimented at the time of Southern monsoon outbreaks for 3 years (2005, 2008 and 2009), corresponding to 18 cases. In each case, there are five trials, including satellite wind data assimilation, upper-air sounding data assimilation, mixed data (satellite wind+upper-air sounding data) assimilation and two controlled trials (one single predictive test and one multi-physical ensemble prediction), which is equivalent to 85 forecasts for one trial. Based on the statistical evaluation of 36 samples (18 meteorological stations and 18 trials), the results show that Kalman filter assimilates satellite wind data to forecast well rainfall at 48 hours and 72 hours ranges. With 24 hour forecasting period, upper-air sounding data assimilation and mixed data assimilation experiments predicted better rainfall than non-assimilation tests. The results of the assessment based on the phase prediction indicators also show that the ensemble Kalman filter assimilating satellite wind data and mixed data sets improve the rain forecasting capability of the model at 48 hours and 72 hour ranges, while the upper-air sounding data assimilation test produces satisfactory results at the 72 hour forecast range, and the multi-physical ensemble test predicted good rainfall at 24 hour and 48 hour forecasts. The results of this research initially lead to a new research approach, Kalman Filter Application that assimilates the existing observation data into input data of the model that can improve the quality of rainfall forecast in Southern Vietnam and overall country in general.References Bui Minh Tuan, Nguyen Minh Truong, 2013. 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The Third International MAHASRI/HyARC Workshop on Asian Monsoon and Water Cycle, 28-30 August 2013, Da Nang, Viet Nam, 217-224.Richardson L.F., 1922. Weather prediction by numerical process. Cambridge University Press, Cambridge. Reprinted by Dover (1965, New York).Routray, Mohanty U.C., Niyogi D., Rizvi S.R., Osuri K.K., 2008. First application of 3DVAR-WRF data assimilation for mesoscale simulation of heavy rainfall events over Indian Monsoon region. Journal of the Royal Meteorological Society, 1555.Schumacher, R. S., C. A. Davis, 2010. Ensemble-based Forecast Uncertainty Analysis of Diverse Heavy Rainfall Events, 25. Doi: 10.1175/2010WAF2222378.Snyder C., Zhang F., 2003. Assimilation of simulated Doppler radar observations with an Ensemble Kalman filter. Mon. Wea. Rev., 131, 1663.Szunyogh I., Kostelich E.J., Gyarmati G., Kalnay E., Hunt B.R., Ott E., Satterfield E., Yorke J.A., 2008. A local ensemble transform Kalman filter data assimilation system for the NCEP global model. Tellus A., 60, 113-130.Tanaka M., 1992. Intraseasonal oscillation and the onset and retreat dates of the summer monsoon east, southeast Asia and the western Pacific region using GMS high cloud amount data. J. Meteorol. Soc. Japan, 70, 613-628.Tan Tien Tran, Nguyen Thi Thanh, 2011. The MODIS satellite data assimilation in the WRF model to forecast rainfall in the central region. VNU Journal of Science, Natural Sciences and Technology, 27(3S), 90-95.Tao S., Chen L., 1987. A review of recent research on East summer monsoon in China, Monsoon Meteorology. C. P. Changand T. N. Krishramurti, Eds, Oxford University Press, Oxford, 60-92.Tippett M.K., Anderson J.L., Bishop C.H., Hamill T.M., Whitaker J.S., 2003. Ensemble square root filters. Mon. Wea. Rev., 131, 1485.Thuy Kieu Thi, Giam Nguyen Minh, Dung Dang Van, 2013. Using WRF model to forecast heavy rainfall events on September 2012 in Dong Nai River Basin. The Third International MAHASRI/HyARC Workshop on Asian Monsoon and Water Cycle, 28-30 August 2013, Da Nang, Viet Nam, 185-200.Xavier, Chandrasekar, Singh R. and Simon B., 2006. The impact of assimilation of MODIS data for the prediction of a tropical low-pressure system over India using a mesoscale model. International Journal of Remote Sensing 27(20), 4655-4676. https://doi.org/10.1080/01431160500207302. Wang B., 2003. Atmosphere-warm ocean interaction and its impacts on Asian-Australian monsoon variation. J. Climate, 16(8), 1195-1211.Wang B. and Wu R., 1997. Peculiar temporal structure of the South China Sea summer monsoon. J. Climate., 15, 386-396.Wang L., He J., and Guan Z., 2004. Characteristic of convective activities over Asian Australian ”landbridge” areas and its possible factors. Act a Meteorologic a Sinica, 18, 441-454.Wang, B., and Z. Fan, 1999. Choice of South Asian Summer Monsoon Indices. Bull. Amer. Meteor. Sci., 80, 629-638.Webster P.J., Magana V.O., Palmer T.N., Shukla J., Tomas R.A., Yanai M., Yasunari T., 1998. Monsoons: Processes, predictability, and teprospects for prediction, J. Geophys. Res., 103, 14451-14510.Wilks Daniel S., 1997. Statistical Methods in the Atmospheric Sciences. Ithaca New York., 59, 255.Whitaker J.S., Hamill T.M., 2002. Ensemble data assimilation without perturbed observations. Mon. Wea. Rev., 130, 1913.Wu G., Zhang Y., 1998. Tibetan plateau forcing and the timing of the monsoon onset over South Asia and the South China Sea. Mon.Wea.Rev., 126, 913-927.Zhang Z., Chan J.C.L., and Ding Y., 2004. Characteristics, evolution and mechanisms of the summer monsoon onset over Southeast Asia. J.Climatology, 24, 1461-1482.http://weather.uwyo.edu/upperair/sounding.html and http://tropic.ssec.wisc.edu/archive/

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« Transport firm delivers on innovation ». Strategic Direction 33, n^o 10 (9 octobre 2017) : 29–31. http://dx.doi.org/10.1108/sd-07-2017-0106.

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Purpose This paper aims to review the latest management developments across the globe and pinpoint practical implications from cutting-edge research and case studies. Design/methodology/approach This briefing is prepared by an independent writer who adds their own impartial comments and places the articles in context. Findings The results confirm management innovation as a complex project concerning organizational routines which represent a central and fundamental element of organizations. Also, it finds that organizational routines evolve in innovation implementation through a three-phase process consisting of the existing-routine-domination phase, the new-routine-creation phase, and solidification phase, each exhibiting different innovation activities and characteristics of participants’ cognition and behaviors; recreation of new routines is the key for routine evolution and, thus, for success of management innovations. Practical implications The paper provides strategic insights and practical thinking that have influenced some of the world’s leading organizations. Originality/value The briefing saves busy executives and researchers hours of reading time by selecting only the very best, most pertinent information and presenting it in a condensed and easy-to-digest format.

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« Prevention is the best cure : human resource planning in Mergers and Acquisitions ». Human Resource Management International Digest 28, n^o 7 (27 juillet 2020) : 15–19. http://dx.doi.org/10.1108/hrmid-05-2020-0134.

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Purpose This paper aims to review the latest management developments across the globe and pinpoint practical implications from cutting-edge research and case studies. Design This briefing is prepared by an independent writer who adds their own impartial comments and places the articles in context. Findings The study proposes a model for HR involvement in the planning phase of M&A’s based on a case study effectively highlighting the importance of HR involvement and planning for successful M&A outcomes. Originality The briefing saves busy executives and researchers hours of reading time by selecting only the very best, most pertinent information and presenting it in a condensed and easy-to-digest format.

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Graham, Flora. « Daily briefing : WHO abandons second phase of COVID-origins investigation ». Nature, 14 février 2023. http://dx.doi.org/10.1038/d41586-023-00465-8.

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Kowaltowski, Doris Catharine Cornelie Knatz, et Marcella Savioli Deliberador. « A briefing game for school building design ». Pro-Posições 30 (2019). http://dx.doi.org/10.1590/1980-6248-2017-0159.

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Abstract The architectural design process is complex, as new technical, social, environmental and economical requirements are introduced, and this very scenario is applicable for school buildings. The quality of a school building depends on known design criteria, professional knowledge and feedback from building performance assessments. To attain high performance school buildings, the design process should add a multidisciplinary team via an integrated process. This article presents a design tool to structure a school building design briefing process. A participatory architectural programming phase is advocated and tested through a focal group, supported by a game called “Shuffle the School Building Design Deck” (SSBDD). The content of SSBDD and application procedure are based on known facts, needs and global concepts for learning environments in the twenty-first century. The briefing game considers the specific context of Brazil. Validation tests show positive results for productive architectural programming for school buildings. SSBDD has potential for global contexts, including translations for other building types.

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« Enhancing strategy effectiveness ». Strategic Direction 34, n^o 1 (8 janvier 2018) : 25–27. http://dx.doi.org/10.1108/sd-10-2017-0153.

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Purpose This paper aims to review the latest management developments across the globe and pinpoint practical implications from cutting-edge research and case studies. Design/methodology/approach This briefing is prepared by an independent writer who adds their own impartial comments and places the articles in context. Findings Opening up the strategy process to a more diverse range of participants can help increase a firm’s competitiveness. However, it is important to enable appropriate social networks to ensure an optimum degree of openness during each of the three process phases. This should help maximize benefits and guard against the possibility of damaging consequences. Originality/value The briefing saves busy executives and researchers hours of reading time by selecting only the very best, most pertinent information and presenting it in a condensed and easy-to-digest format.

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« Declarative knowledge and product development process ». Development and Learning in Organizations : An International Journal, 15 novembre 2022. http://dx.doi.org/10.1108/dlo-10-2022-0196.

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Purpose This paper aims to review the latest management developments across the globe and pinpoint practical implications from cutting-edge research and case studies. Design/methodology/approach This briefing is prepared by an independent writer who adds their own impartial comments and places the articles in context. Findings Firms are able to enhance their product development process (PDP) by utilizing of a Stage-Gate (SG) system to evaluate its performance. Emphasis on declarative knowledge elements during analysis of critical events at each phase of SG can facilitate learning within and across teams and help achieve the goal of continuous improvement through learning. Originality/value The briefing saves busy executives and researchers hours of reading time by selecting only the very best, most pertinent information and presenting it in a condensed and easy-to-digest format.

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Anh Tam, Ho, et Do Thi Huong Giang. « Research and Development of Mobile Marine Satellite Antenna System in Vietnam ». VNU Journal of Science : Natural Sciences and Technology 35, n^o 2 (28 juin 2019). http://dx.doi.org/10.25073/2588-1140/vnunst.4903.

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Abstract: A second version of the mobile marine satellite communication signal receiver station has been designed, manufactured, assembled and tested using domestically engineered mechanical modules, commercial and low-cost integrated sensors, motors and drivers. The operating mechanical components have been developed in the form of independently operating modules with handling ease and high sensitivity at a “clearance” in the order of 10µm. The sensors are of high and firm integration and good noise compensation facilities. The appropriately developed automatic control algorithms and software allow efficient and safe searching and following the broadcasting satellite of the antenna device installed on a marine transport boat. Compared to the previous version, this new development has more optimal dimensions, is easier and more flexible to start up and operate with operating parameters of pitch: 15-80° (±0.5°), yaw: of 0-360° (±0.25°), and polarization angle of 0-360° (±0.5°). The antenna turn rates are of ~12°/s and 12°/s2. All the components of the complete system are water- and weather proof and packaged to ensure safe operation in marine conditions. Running tests have been successfully taken in real sunny weather conditions on a sea boat speeding at 30 km/h with a wind velocity up to 19 km/h. The article concludes that domestically engineered, the device is more financially efficient than imported counterpart equipments as well as promising in terms of technology transfer to mass production by domestic businesses. Keywords: Satellite receiver antenna, marine satellite antenna, antenna angle controller, sensors. References [1] B. Schneiderman, Executive Roundtable on Maritime and Energy Markets, Satellite Executive Briefing, Vol. 11 No. 8 (2018) 9.[2] L.M. Bradbury, D. Diaconu, S. Molgat Laurin, A.M. Beattie, C. Ma, I.S. Spydevold, H.C. Haugli, R.E. Zee, J. Harr, F. Udnæs, NorSat-2: Enabling advanced maritime communication with VDES, Acta Astronautica, 156 (2019) 44-50[3] Y.J. Song, P.S. Kim, D.G. Oh, et al., Development of mobile broadband interactive satellite access system for Ku/Ka band, International journal of satellite communications and networking, 24 (2007) 101-117. [4] Y.J. Song, M.S. Shin, B.H. Kim, et al, Development of mobile broadband satellite access system for Ka/Ku-band satellite communications, Ieice transactions on communications, e87b (2004) 2152-2161.[5] S. Pekowsky, G Pousset, Y. Levy, MobileTV Receiver Technology with special emphasis on DVB-SH, international journal of satellite communications and networking, 27 (2009) 275-293.[6] http://www.raysat.com/mobile_satellite_television_antennas.[7] Nguyễn Hữu Đức, Bùi Đình Tú, Nguyễn Thị Ngọc, Đồng Quốc Việt, Đỗ Thị Hương Giang, Trạm thu di động thông tin vệ tinh dựa trên sensơ từ trường độ nhạy cao ứng dụng trên tàu biển, Tuyển tập Hội thảo khoa học Công nghệ vũ trụ và ứng dụng, Hà Nội, 2014.[8] M. Geissler, F. Woetzel, M.Böttcher, S. Korthoff, A.Lauer, M.Eube, R. Gieron, Roman, Innovative phased array antenna for maritime satellite communications, EuCAP 2009. 3rd European Conference on Antennas and Propagation, (2009)735-739[9] http://www.orbit-cs.com/modular-maritime-communications-system[10] https://www.digisat.org/maritime-satcom-vsat[11] https://paracomm.co.uk/[12] https://www.intelliantech.com/?lang=en.[13] Nguyễn Hữu Đức, Báo cáo tổng kết đề tài đề tài “Thiết kế và chế tạo trạm thu di động thông tin vệ tinh dựa trên sensơ từ trường độ nhạy cao ứng dụng trên tàu biển”, Chương trình KH&CN quốc gia về Công nghệ vũ trụ giai đoạn 2013-2015, Hà Nội, 2016.

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