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1
Newall, Carol Anne. « Herbal medicines and pharmacy ». Thesis, University College London (University of London), 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.286407.
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Hsiao, I.-Hsuan. « Pharmaceutical patent jurisprudence and the modernization of Chinese herbal medicine ». Thesis, Queen Mary, University of London, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.515514.
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Nolan, J. E. « Investigations on Gor-Kan-Shan-Lien-Tan, a Chinese herbal medicine ». Thesis, Cardiff University, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.372346.
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Sehume, Brian J. « Pharmaceutical evaluation of phela capsules Used as traditional medicine ». Thesis, University of the Western Cape, 2010. http://etd.uwc.ac.za/index.php?module=etd&action=viewtitle&id=gen8Srv25Nme4_6049_1299482219.
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In conclusion, the results obtained firstly indicated that the BP, EMEA and WHO were in fairly good agreement on the criteria and specifications that can be used to assesses the pharmaceutical quality of a traditional plant medicine such as Phela. Secondly, the Phela plant powders were found to have acceptable pharmaceutical properties that did not complicate or adversely affected the capsule manufacture. Thirdly, the Phela capsules produced were generally of acceptable pharmacopoeial standard. Fourthly, HPLC fingerprinting and pattern recognition analysis proved useful to examine the chemical stability of selected marker compounds of Phela and indicated that the capsules had no practical shelf life under elevated temperature and humid conditions. Overall, the Phela capsules should thus be suitable for use in a short time clinical trial, but for use in a long period trial the long term stability of the Phela capsules under ambient conditions must still be confirmed.
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Wen, Wucheng. « Development and Evaluation of Nano-herbal Therapy for Metastatic Breast Cancer Treatment ». Diss., Temple University Libraries, 2018. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/534260.
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Pharmaceutical SciencesPh.D.
Triptolide (TPL), a diterpenoid triepoxide that is extracted from a traditional Chinese herb called Tripterygium Wilfordii (also known as ‘Thunder God Vine’) has recently drawn increasing interests from pharmaceutical and biomedical researchers, especially in the aspect of its potential efficacy on multiple cancer treatment. TPL has shown significant growth and proliferation inhibition activities in a broad range of cancer cell types. Moreover, it has shown the inhibition of osteoclastogenesis by breast cancer bone metastasis. However, due to its limitation in toxicity, solubility and non-specific biodistribution, it is challenging for the application of TPL in clinical study. Besides, TPL can rapidly distribute in most vital organs and no evidences shown tissue accumulation of drug. It is indispensable to overcome those barriers and optimize the properties and performance of the promising drug molecule. Lipid-based nanocarriers such as nanostructured lipid carriers (NLC) have been extensively studied for delivery of poorly-water soluble drug compounds. They also have the potential to optimize the physicochemical properties of the drug and may enhance a targeted delivery of the drug to specific therapeutic site. Alendronate (Fosamax®), an FDA approved bisphosphonate drug for osteoporosis, osteogenesis imperfecta and several other bone diseases, has been used as a bone targeting decoration agent. Breast cancer cell line MDA-MB-231 and other type of cancer cell lines have been used to study the in vitro cytotoxicity of TPL and the carriers while MC3T3-E1 cell line was used for toxicity assessment. Rats have also been used to study the in vivo performance of the drug. After modifying and optimizing the formulation of the particle, the formulation had the ability to remain structurally and functionally stable when being in the bio-simulated media at 37 °C and in water at room temperature with high encapsulation efficiency. In vitro study illustrated that both TPL free drug (stock solution 10mg/mL dissolved in DMSO) and TPL nanoparticle without alendronate (TPL-NP) had similar cytotoxicity on MDA-MB-231 and some other type of cancer cell lines. The ALE decoration on the particle (ALE-NP-TPL) has enhanced the anti-cancer effect especially with breast cancer cell line. The in vivo study shows that after 24 hours of the dose injection at local bone site, the formulation and TPL can remained at the location without random distribution to other organs. TPL-NP has not only successfully optimized the physicochemical properties of the drug, but also shows great enhancement of therapeutic effect both in vitro and in vivo study.
Temple University--Theses
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Thomas, C. M., et John B. Bossaer. « Patient Use of Herbal Supplements in an Outpatient Hematology/Oncology Medical Clinic ». Digital Commons @ East Tennessee State University, 2012. https://dc.etsu.edu/etsu-works/2356.
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Primary Objective: According to the National Center for Health Statistics, many Americans use some type of vitamin or supplement. A recent study of cancer patients in the VA medical system found that a significant number of cancer patients do not mention the use of supplements to their healthcare providers. Many of these supplements were also found to interact with or compound side effects of chemotherapy regimens. The purpose of this study is to determine the incidence of cancer patients taking supplements and to determine the completeness of home medication lists in regard to vitamins or herbal supplements.
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Cai, Xiong. « The anti-arthritic effect and underlying mechanisms of QFGJS, a pharmaceutical preparation from a Chinese herbal formula ». HKBU Institutional Repository, 2006. http://repository.hkbu.edu.hk/etd_ra/722.
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Seneca, Michael J. « Meta-Analysis of Herbal Cannabis Therapy for Chronic Pain ». UNF Digital Commons, 2014. http://digitalcommons.unf.edu/etd/503.
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Since the first so-called “medical marijuana” legislation was passed in California in 1996, a total of twenty states and the District of Columbia have passed laws permitting limited use of cannabis. Despite the changes in state laws, cannabis remains illegal for any purpose under federal law. Changes in state laws have coincided with a renewed interest in the substance for the treatment of a variety of conditions. There has been a significant increase in published data over the past twenty years examining the efficacy of cannabis as an appetite stimulant, antiemetic agent, and analgesic adjuvant. The purpose of this meta-analysis was to synthesize published data on cannabis use as an analgesic agent. Five studies meeting inclusion criteria were located through searches of online databases, review of reference lists, author correspondence, and review of clinical trials databases. Meta-analysis was conducted using fixed-effects modeling. The overall effect of mean reduction of pain intensity was -4.895 (Z-score) with an associated p value of 0.003. The combined standardized mean difference (SMD) was -0.362 (CI -0.507 to -0.217), indicating on average a moderate significant reduction in pain intensity for patients with chronic pain. As the legal status of the substance evolves, additional research is needed to establish evidence-based clinical recommendations regarding the use of medicinal cannabis in pain management.
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Bossaer, John B., et Brian L. Odle. « Probable Etoposide Interaction with Echinacea ». Digital Commons @ East Tennessee State University, 2012. https://dc.etsu.edu/etsu-works/2317.
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Echinacea is an herbal supplement commonly used as an immune system stimulant to prevent infections, such as the common cold or flu. Echinacea has been documented as a cyctochrome P450 (CYP) 3A4 inhibitor in vitro, but no formal studies have been conducted in humans. Etoposide is a cytotoxic, topoisomerase II inhibitor, chemotherapeutic agent used in the treatment of lung cancer. Etoposide is primarily metabolized by CYP 3A4. We report the first possible drug–herbal interaction between Echinacea and etoposide. A 61-year-old gentleman newly diagnosed with nonsmall cell lung cancer began concurrent chemoradiation with cisplatin and etoposide. He was admitted to the hospital on day 8 of his first cycle and found to be thrombocytopenic. His platelet count eventually reached a nadir of 16 × 103/L, requiring platelet transfusion support. Upon admission, it was discovered he was taking Echinacea, which was discontinued. He received his next cycle of chemotherapy without taking Echinacea. His platelet count decreased to a nadir of 44 × 103/L, but he did not require platelet transfusions. Echinacea likely contributed to this patient's profound thrombocytopenia and should be avoided in patients receiving etoposide and possibly other chemotherapeutic drugs that are CYP 3A4 substrates.
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游暢. « 疏水與溶脹材料混合作為溶脹層的水溶性小分子藥物遲釋微丸的製備, 表徵與體內評價 ». Thesis, University of Macau, 2012. http://umaclib3.umac.mo/record=b2590317.
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Wang, Li. « ASSESSMENT OF THE DRUG-DRUG INTERACTION POTENTIAL OF ANIONIC COMPONENTS IN THE DIET AND HERBAL MEDICINES ON ORGANIC ANION TRANSPORTERS (SLC22 FAMILY) ». VCU Scholars Compass, 2013. http://scholarscompass.vcu.edu/etd/3181.
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Numerous natural products are widely used as first-line/alternative therapeutics and dietary supplements in both western and eastern society. However, the safety and efficacy profiles for herbal products are still limited. Organic anion transporters (OATs; SLC22 family) are expressed in many barrier organs and mediate in vivo body disposition of a broad array of endogenous substances and clinically important drugs. As some dietary flavonoids and phenolic acids were previously demonstrated to interact with OATs, it is necessary to explore the potential interaction of such components found in natural products in order to avoid potential OAT-mediated drug-drug interactions (DDIs). The inhibitory effects of 23 natural products were assessed on the function of human (h) OATs, hOAT1 (SLC22A6), hOAT3 (SLC22A7), and hOAT4 (SLC22A11) and/or the murine (m) orthologs mOat1 and mOat3. For compounds exhibiting marked inhibition at initial screening, dose-response curves (IC50 values) and DDI indices were determined. At the initial screening concentrations, 14, 19, and 2 test compounds exhibited significant inhibition on hOAT1, hOAT3, and hOAT4, respectively. Additionally, all test Danshen (a Chinese herbal medicine) hydrophilic components significantly reduced mOat1- and mOat3-mediated substrate uptake at 1 mM. For selected compounds, the IC50 and Ki values were estimated to be in the micromolar or even nanomolar range. Considering the clinical plasma concentration and unbound fraction in plasma, DDI indices for gallic acid, gentisic acid, lithospermic acid, protocatechuic acid, rosmarinic acid, salvianolic acid B, and tanshinol indicated DDIs may occur in vivo in situations of co-administration of these compounds and clinical therapeutics known to be OAT substrates. Finally, a new, rapid, and sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated to quantify gallic acid and gentisic acid in cell lysates in order to measure cellular uptake of these compounds in mOat1- or mOat3-expressing cells. Significant cellular uptake of gallic acid was observed in mOat1-expressing cells, compared with background control cells. The absorptive uptake was completely blocked by probenecid (known OAT inhibitor) at 1 mM. These results indicate that gallic acid is a substrate for mOat1 and suggest that human OAT1 might be involved in the active renal secretion of gallic acid.
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Said, Mazlina Mohd. « Chemometrics study and spectral database development of pharmaceuticals and herbal products : Malaysian perspective ». Thesis, University College London (University of London), 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.550960.
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The issues for drug qualities, distribution of counterfeit and adulterated medicines in the market are not rare globally and rather common in a developing country like Malaysia. Despite stringent legislation and monitoring by the government, the problems still exist and the number of cases kept on increasing each year. This research aimed to design and proposed a strategy that can be used to overcome these problems. A combination of near infrared (NIR), mass spectrometry (MS) and nuclear magnetic resonance (NMR) spectral databases and chemometrics analyses of their spectroscopic fingerprints for product was used for the comparison and classification of samples. A customized spectral database was created and experimental strategy was designed to use this database as a potential tool for a quick screening of product identification and classifications. A direct comparison between different products and their classification without the use of a reference standard was demonstrated. Further analysis by NMR and MS was employed to distinguish similar or ambiguous results. In general, this thesis can be divided into two parts. In the first part, spectral analysis using different techniques were discussed and graphical presentations on these spectra in the database were shown using chemometric analysis. Principal component Analysis (PCA) and soft independent modeling of class analogy (SIMCA) were the main chemometric tools used throughout the research. Details on the development of spectra database were also discussed in this part. This was including the database construction and search methods as well as the determination of the best search algorithms and cut-off values for the most accurate search outcome. The uses of the proposed strategy were demonstrated in the second part. Four main areas discussed including identification of unknown spectra, drug quality study, herbal product analysis and spectroscopic analysis of adulterated and counterfeit samples. The outcomes of this thesis is hoped to be the stepping-stone for further researches on qualitative and quantitative analysis of local pharmaceuticals in Malaysian's Universities. Other than that, the presence of drugs spectral database in particular, means to initiates and assists in quality drug surveillance nation-wide.
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Patnala, Satya Siva Rama Ranganath Srinivas. « Pharmaceutical analysis and quality of complementary medicines : sceletium and associated products ». Thesis, Rhodes University, 2007. http://hdl.handle.net/10962/d1018263.
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There has been an upsurge in the use of Complementary and Alternate Medicines (CAMs) in both developed and developing countries. Although herbal medicines have been in use for many centuries, their quality, safety and efficacy are still of major concern. Many countries are in the process of integrating CAMs into conventional health care systems based on the knowledge and use of traditional medicines. The quality control (QC) of herbal products usually presents a formidable analytical challenge in view of the complexity of the constituents in plant material and the commercial non-availability of appropriate qualified reference standards. Sceletium, a genus belonging to the family Aizoaceae, has been reported to contain psychoactive alkaloids, specifically mesembrine, mesembrenone, mesembrenol and some other related alkaloids. Sceletium is marketed as dried plant powder and as phyto-pharmaceutical dosage forms. Sceletium products and plant material marketed through health shops and on the internet are associated with unjustified claims of specific therapeutic efficacy and may be of dubious quality. Validated analytical methods to estimate Sceletium alkaloids have not previously been reported in the scientific literature and the available methods have focused only on qualitative estimation. Furthermore, since appropriate markers were not commercially available for use as reference standards, a primary objective of this study was to isolate relevant compounds, qualify them as reference standards which could be applied to develop appropriate validated qualitative and quantitative analytical methods for fingerprinting and assay of Sceletium plant material and dosage forms. The alkaloidal markers mesembrine, mesembrenone and ∆⁷ mesembrenone were isolated by solvent extraction and chromatography from dried plant material. Mesembranol and epimesembranol were synthesised by hydrogenation of the isolated mesembrine using the catalyst platinum (IV) oxide and then further purified by semi-preparative column chromatography. All compounds were subjected to analysis by ¹H, ¹³C, 2-D nuclear magnetic resonance and liquid chromatography-tandem mass spectroscopy. Mesembrine was converted to hydrochloride crystals and mesembranol was isolated as crystals from the hydrogenation reaction mass. These compounds were analysed and characterised by X-ray crystallography. A relatively simple HPLC method for the separation and quantitative analysis of five relevant alkaloidal components in Sceletium was developed and validated. The method was applied to determine the alkaloids in plant material and dosage forms containing Sceletium. An LCMS method developed during the study provided accurate identification of the five relevant Sceletium alkaloids. The method was applied for the quantitative analysis and QC of Sceletium plant material and its dosage forms. This LCMS method was found to efficiently ionize the relevant alkaloidal markers in order to facilitate their detection, identification and quantification in Sceletium plant material as well as for the assay and QC of dosage forms containing Sceletium. The chemotaxonomy of some Sceletium species and commercially available Sceletium dosage forms were successfully studied by the LCMS method. The HPLC and LCMS methods were also used to monitor the bio-conversion of some of the alkaloids while processing the plant material as per traditional method of fermentation. Additionally a high resolution CZE method was developed for the separation of several Sceletium alkaloids in relatively short analysis times. This analytical method was used successfully to fingerprint the alkaloids and quantify mesembrine in Sceletium and its products. Sceletium species grown under varying conditions at different locations, when analyzed, showed major differences in their composition of alkaloids and an enormous difference was found to exist between the various species with respect to the presence and content of alkaloids. Sceletium and its products marketed through health shops and the internet may thus have problems with respect to the quality and related therapeutic efficacy. The QC of Sceletium presents a formidable challenge as Sceletium plants and products contain a complex mixture of compounds. The work presented herein contributes to a growing body of scientific knowledge to improve the QC standards of herbal medicines and also to provide vital information regarding the selection of plant species and information on the specific alkaloidal constituents to the cultivators of Sceletium and the manufacturers of its products.
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Dubber, Mary-Jean. « Application of CE, HPLC and LC-MS-MS for the analysis and quality control of Ginkgo biloba dosage forms ». Thesis, Rhodes University, 2006. http://hdl.handle.net/10962/d1003235.
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Natural products are complex mixtures of compounds with therapeutic effects which are often reported to be due to the synergistic action of multiple and sometimes unknown components. Consequently, standardization of these products is complex and a lack of effective quality control (QC) criteria in most countries has led to marketing of commercial products with questionable quality, safety and efficacy (QSE). The aim of this study was therefore to develop qualitative and quantitative analytical methods for use in the QC of Ginkgo biloba solid oral dosage forms. Initially, a micellar electrokinetic chromatography (MEKC) method was developed for the identification of the flavonol glycosides, rutin and quercitrin as well as 3 flavonol aglycones, quercetin, kaempferol and isorhamnetin in crude extracts of 4 Ginkgo biloba solid oral dosage forms using ultraviolet (UV) detection. A reversed-flow cyclodextrin-modified MEKC method was subsequently developed for the simultaneous determination of the aforementioned flavonols as well as ginkgolide A, B, C, J and bilobalide (all positive markers) in Ginkgo commercial products. A non-aqueous capillary electrophoresis (CE) method was also developed for fingerprinting the presence of ginkgolic acids (negative markers) in Ginkgo biloba leaf extracts, which are purported to be associated with toxic properties. This method was also applied to 2 Ginkgo biloba commercial products. Since the flavonols have strong UV absorbing chromophores, a reversed phase high-performance liquid chromatographic (RP-HPLC) method was developed and validated using photo-diode-array (PDA) detection which was then successfully applied to fingerprint commercially available Ginkgo biloba solid oral dosage forms as well as quantify the relevant flavonol markers present in these extracts. Sample preparation was simple, rapid and cost efficient with minimal clean-up and the employment of a minibore column which requires low mobile phase flow rates contributed to the economy of the method. Unlike the conventional QC approach, samples were not hydrolyzed and direct determination of 2 intact flavonol glycosides, together with the usual aglycone markers was facilitated which provided maximal content information for fingerprint comparisons. On the other hand, terpene trilactones possess poor chromophores and an alternative detection method to UV was required in order to obtain suitable sensitivity. RP-HPLC with evaporative light scattering detection (ELSD) was selected for quantification of these non-volatile constituents in Ginkgo dosage forms and this method was deemed suitable for the routine QC analysis of these positive markers in commercial products. Since approximately 33 flavonoids have been identified in Ginkgo biloba leaf extracts, baseline separation using UV/PDA detection normally requires complex gradient programs and long analysis times. In addition, unequivocal identification of the flavonoids with similar UV spectra and elution times cannot be guaranteed. A liquid chromatographic tandem mass spectrometric (LC-MS-MS) method was therefore developed and validated in order to ensure accurate quantification of the selected flavonol marker compounds in Ginkgo commercial products. LC-MS-MS analysis of Ginkgo extracts revealed, in addition to rutin, the possible presence of other quercetin analogues, quercetin-3-Orhamnoside-7-O-glucoside or quercetin-3-O-glucoside-7-O-rhamnoside, previously unreported in Ginkgo biloba leaf extracts or dosage forms. In terms of evaluating the most suitable analytical method for QC, CE shows exceptional potential in the future analysis of Ginkgo biloba dosage forms while HPLC-PDA and HPLC-ELSD are currently the most affordable and practical instruments for the routine analysis of the flavonols and terpenoids, respectively. LC-MS-MS proved to be pivotal for the accurate identification and quantification of the flavonols due to interference by other flavonoid compounds with similar retention times and UV spectra to the peaks of interest. All quantitative and qualitative results revealed large discrepancies in the marker content between the products regardless of which batch was analysed and product labels disclosed little relevant information. Although currently not required by most regulatory agencies, some of the usual quality criteria applied to orthodox medicines was evaluated. In particular, dissolution analysis, disintegration, tablet hardness and weight uniformity were assessed and revealed similar inconsistencies. This thesis emphasises that implementation of effective QC criteria is long overdue and is essential to ensure consistent product QSE of commercially available Ginkgo biloba solid oral dosage forms.
15
Nakamoto, Christine Machiko. « California psychologists' knowledge of medicinal herbs as it relates to discussions and recommendations of them when counseling clients ». Scholarly Commons, 2004. https://scholarlycommons.pacific.edu/uop_etds/2430.
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There has been a tremendous growth in popularity in the use of herbs especially those designed to assist with mental wellness and to reduce psychological ailments. Clients' widespread usage of medicinal herbs for psychologically related symptoms has created a need for psychologists to become more informed about the health risks associated with taking medicinal herbs. It is important that psychologists be familiar with the most current information regarding medicinal herbs to be able to initiate discussions about medicinal herbs with their clients to help mitigate potential health risks. This study was conducted to increase knowledge about psychologist's perceptions and knowledge about medicinal herbs and about psychologist's practices regarding discussions and recommendation of medicinal herbs with their clients. A total of 1963 questionnaires were responded to by licensed psychologists in the state of California. Most psychologists felt they either did not have enough knowledge or that more knowledge was needed about medicinal herbs. The results show that there is a positive association between psychologist's perceived knowledge of medicinal herbs and their willingness to initiate discussions about them. It was also shown that the more perceived knowledge of medicinal herbs by psychologists, the more willing the psychologists were to recommend them. There was hesitancy among some psychologists to talk about herbs as they felt they either did not have the expertise or that it was beyond the scope of their practice to do so. As many medicinal herbs have significant pharmacological activity and thus potential adverse effects and drug interactions, psychologists should be familiar with herbs, their therapeutic modalities, and safety, so they will be better able to discuss these issues with their clients.
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Mngeni, Nasipi Zamanala. « Bioactive compounds from selected medicinal plants used in antidiabetic treatment ». Thesis, Cape Peninsula University of Technology, 2017. http://hdl.handle.net/20.500.11838/2665.
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Thesis (MTech (Chemistry))--Cape Peninsula University of Technology, 2017.The continued use and popularity of plant-based traditional medicine demands scientific validation of the therapeutic potential of the medicinal plants used in disease management and treatment. These medicinal plants are to be evaluated for phytochemical constituents and pharmacologically screened for their bioactivity and include the isolation and identification of their bioactive compounds. The diabetes tea and its eight individual plants constituents were collected from Sing Fefur Herbs in McGregor, Western Cape. The plant material was ground to a fine powder form using a milling machine. The powdered plant material was sequentially extracted with hexane, 1:1 DCM, DCM:MeOH, MeOH and water. The antioxidant activity of the tea and its plants was evaluated with comparison to the antioxidant activity of brewed rooibos tea in literature. The concentration of antioxidants in the plants and the tea were found to be significantly high. The ORAC assay results of the water extracts were significantly higher than that of rooibos tea in all plants. Salvia africana-caerulea water extract ORAC results were 14147.10±1.02 μmol TE/g and this is 10 times better than the brewed rooibos tea results of 1402±44.1 μmol TE/g. The alpha-amylase enzyme inhibition assay showed no significant results while the alpha-glucosidase enzyme inhibition assays showed significant results in some of the extracts. The highest inhibitory activity towards alpha-glucosidase was found in the Urtica urens hexane extract and the Thymus vulgaris hexane extract (69.66% and 68.43%, respectively). This observation suggests that alpha-glucosidase enzyme is inhibited mostly by the less polar or medium polarity chemical components of the plant extracts. The crude plant extracts that showed significant activity in the antidiabetic bioassays were further subjected to cytotoxicity assay to ascertain the safety of extracts. The T. vulgaris DCM extract, Salvia officinalis DCM extract and Salvia officinalis hexane extract showed a cell growth inhibition of 54.91%, 62.14% and 63.87% at 100 μg/ml, respectively. The Salvia africana-caerulea DCM extract showed a cell growth inhibition of 59.10% at 50 μg/ml and 62.14% at 100 μg/ml. In the cytotoxicity analysis Salvia africana-caerulea DCM extract is the only extract that showed cell viability below 50% for both concentrations. Phytochemical screening of selected methanolic and aqueous extracts of the diabetes tea and the Salvia africana-caerulea showed the presence of alkaloids, sugars, flavonoids, glycosides, proteins & amino acids, phenolics & tannins and saponins. Furthermore isolation, purification and analysis of two Salvia africana-caerulea crude extracts (DCM and DCM:MeOH) were done in order to try and obtain pure compounds. The compound characterization was done through the use of chromatographic techniques. Thin layer chromatography (TLC), flash chromatography and column chromatography resulted in the generation of 29 fractions. Spectroscopic techniques utilized for chemical structural elucidation for compounds of interest included Liquid chromatography mass spectrometry and Nuclear Magnetic Resonance Spectroscopy. Of all the fractions generated, DM 23 was the purest and its structural elucidation was attempted.
17
Chow, Jane. « Benefits of incorporating Chinese herbal medicine into current pharmaceutical regimens ». Thesis, 2020. https://hdl.handle.net/2144/42089.
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Chinese Herbal Medicine has been mainstream practice for hundreds of generations, however the merits of herbal therapeutics have been debated in the era of modern medicine. With a shift towards scientific analysis and rigorous testing of conventional pharmaceuticals in the past century, critics have questioned the proclaimed effects of herbal concoctions. Nonetheless, herbal medicines are still used frequently and have spawned clinical studies meant to determine their therapeutic efficacy. This paper aims to evaluate many aspects of Chinese Herbal Medicine applications that have already been analyzed in other papers, then propose a study which explores the effects of the herbal concoction Ban Xia Bai Zhu Tian Ma Pian in lowering blood pressure. Hypertension was chosen as the focus of the study due to its extensive presence in the population and the impact a significant outcome can provide given its prevalence. The ultimate goal is to find a balance between both eastern and western practices of medicine, thus preserving Chinese medical traditions that are concurrently buttressed by scientific research.
18
Gedif, Fenta Teferi. « Herbal medicine in Central Ethiopia : utilisation pattern and its pharmaceutical significance / ». 2003. http://www.gbv.de/dms/bs/toc/361427204.pdf.
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Chang, Ya-Lin, et 張雅玲. « Pharmaceutical property analysis of cosmetic Chinese herbal medicines in ancient Pharmacopoeia ». Thesis, 2013. http://ndltd.ncl.edu.tw/handle/06532874974938931554.
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碩士亞洲大學
保健營養生技學系碩士班
101
Our country's first monograph of herbalism "Shen Nong's Herbal Classic" clearly indicate a cosmetic effect of 63 kinds of Chinese medicine. Sui Chao Yuan Fang Zhu treat patients, "annexed to the" health guidance law on the records of massage and beauty. Tang after the 《emergency preparedness daughter to party》《 Herbal 》《Diet Herbal 》《 Eat a meal 》《 With the interest rate home food spectrum》and so documented a variety of beauty, the beauty of Chinese medicine has excellent long and rich connotations. This study analyzes published by the Committee on Chinese Medicine and Pharmacy, Department of Health in the Republic a hundred years in June [beauty among the classics of Traditional Chinese Medicine literature analysis (Chang, 2011) in ancient Chinese medicine information collected, in which the beauty of Chinese herbal medicines such items up to 384 pens, the beauty in Chinese medicines for up to 28 categories described in the vocabulary of the beauty and efficacy of up to 818. 384 pen of Chinese herbal medicines information in accordance with "drug class", "gas", "weird", "Meridian", "effectiveness" field to compile information on the form and coding, the use of statistical methods to analyze the drug classification "gas", and "flavors", "Meridian" and "cosmetic effect" correlation between the pairwise results. The correlation analysis using the SPSS statistical software, the relevant comparison. The Chinese medicine herbal theory of the four gas, flavors, Meridian and summarized the effectiveness of the role of traditional Chinese medicine, this study for analysis using the wisdom of ancient Chinese medicine, the use of statistical methods and analyzed the relationship of potency and efficacy of 384 pen beauty of traditional Chinese medicines, traditional Chinese medicine. The findings provide further scientific experimental research in the modern study of beauty in Chinese medicines, and forecast the strength of the effectiveness of traditional Chinese medicine in the role of beauty
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Lin, Yu-Fang, et 林妤芳. « The Feasibility Study of Applying RFID on SCM - A Case Study on Chinese Herbal Pharmaceutical Industry in Taiwan ». Thesis, 2008. http://ndltd.ncl.edu.tw/handle/6y79s9.
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碩士崑山科技大學
企業管理研究所
96
Along with the coming of aging society and the implementation of National Health Insurance and relevant medicine regulatory, huge growth of Taiwanese pharmaceutical companies is foreseen in future consumer market due to the increase demand of healthcare product. However, as Taiwan joined WTO in 2002, the price of imported medicine was significantly reduced by tariff-reduction; therefore, the market of domestic medicine has been squeezed. Moreover, numerous cases of adulterated food and counterfeit medicine have caused enormous economic loss to the whole society, and effective food and medicine safety management has thus become a hot topic recently. On the other hand, international retail giants started to request their suppliers to deploy RFID tags since 2005, this study analyzed the evaluation process of employing RFID and identified the consideration factors in employing RFID. Chinese herbal medicine industry is taken as an example to analyze the feasibility of employing RFID technology to supply chain. Based on literature review and integration, this study identified main factors influencing the willingness of Chinese herbal medicine pharmaceuticals employing RFID technology. Analytic hierarchy process was performed on three major items and fifteen minor items to obtain three most important dimensions: cost, application consideration, and data flow. Both domestic Chinese herbal medicine pharmaceuticals and RFID experts recognize the software and hardware equipment cost factor is the most influential factor for overall costs, back-end application system integration is the most influential factor for overall application consideration, and sharing of B2B product data is the most influential factor for overall data flow. In general, the price of software and hardware equipment has been considered as the key factor influencing the willingness of business to employ RFID technology, but different industry has different range of price acceptance. Hence, RFID can play a significant role on some high price and high value-added products.
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Chang, Yi-Jui, et 張益瑞. « Research on Decision Factors for Supply Chain Member to Adopt SCM- A Study on Chinese Herbal Pharmaceutical Industry in Taiwan ». Thesis, 2005. http://ndltd.ncl.edu.tw/handle/23272146318429358928.
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碩士中原大學
資訊管理研究所
93
Abstract Chinese Herbal Pharmaceutical Industry is our heritage and become more and more important during recent years. However, our Chinese Herbal Pharmaceutical Industry is facing big challenge. This industry has many problems such as insufficient resources of itself, small scale of company, low production efficiency, too many items and long period for providing and supplying ingredients and materials which is the most serious problem in our Chinese Herbal Pharmaceutical Industry. To solve above mentioned problems. The government provides subsidies and promotes electronic managements of supply chain in Chinese herbal medicine industries. However, there are a lot of considerations for the development of an inter-organization information system. Although most of Chinese herbal medicine industries agree that it is important to integration, they are not enthusiastic about SCM promotion. What kind of reason can push members to adopt Supply Chain Management (SCM)? Chinese Herbal Pharmaceutical Industry will be our key industry in the future. It is an important topic for strengthening the competitiveness of Chinese Herbal Pharmaceutical Industry by I.T. assistance. Therefore, this research took our Chinese Herbal Pharmaceutical Industry as the subject and tried to realize those factors that members consider if they will adopt SCM or not by having deeply interviews with owners of eight representative companies. This research adopts Theory of Planned Behavior (TPB) proposed by Ajzen (1985, 1989) and proceeded this research by outside variables of attitudes, subjective standards, cognitive action control and so on. This research found that project costs reducing due to government subvention has positive influences on member participation indeed. But the main factor to influence member participation is related to the trust between members of organizations, the industry property, the electronic level of each member and so on. The interaction between the groups formed by members would affect member’s decision as well. Thus, the industry determined to promote SCM has to consider many factors at the same time. Keywords: Supply Chain Management, Chinese Herbal Pharmaceutical Industry, Theory of Planned Behavior (TPB)
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Gil, Joana da Ponte e. Sousa. « Chás e infusões : bebidas funcionais com acção sobre o sistema nervoso central ». Master's thesis, 2013. http://hdl.handle.net/10437/4331.
Texte intégralRésumé :
Orientação: Rute VítorNesta monografia pretende-se aprofundar o tema da utilização de infusões de plantas com acção sobre o sistema nervoso central. De acordo com a Organização Mundial de Saúde (OMS), 80% da população mundial utiliza medicamentos à base de plantas como primeira escolha em cuidados de saúde. Tem-se verificado, nas últimas décadas, um aumento da procura dos chamados “produtos naturais” em detrimento dos medicamentos sintéticos, devido, muitas vezes, à ideia errada de que não apresentam efeitos secundários nefastos. As infusões de plantas são a forma de fitoterapia mais popular em todo o Mundo, sendo utilizada há milhares de anos. Existe uma enorme variedade de plantas com actividade biológica e medicinal acessível a qualquer pessoa, o que nem sempre é um ponto positivo, pois os efeitos fisiológicos podem não ser sempre benéficos, além de existir a possibilidade de interacções com medicamentos. Devido às mudanças no estilo de vida das populações, observa-se uma maior prevalência de sintomas como fadiga, ansiedade e, por vezes, depressão moderada, o que leva à procura de soluções caseiras e “naturais” para combater estes problemas. Assim, são abordadas neste trabalho as plantas que, tendo sido já extensamente estudadas, apresentam efeitos benéficos a nível do sistema nervoso, como a valeriana na ansiedade e insónia, o hipericão na depressão moderada, ou o chá como estimulante.
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Dubber, Mary-Jean. « Application of CE, HPLC and LC-MS-MS for the analysis and quality control of Ginkgo biloba dosage forms / ». 2005. http://eprints.ru.ac.za/294/.
Texte intégral
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Maree, Johanna Elizabeth. « Development of a quality control protocol for Pelargonium sidoides DC using Fourier transform infrared spectroscopy ». Thesis, 2009. http://encore.tut.ac.za/iii/cpro/DigitalItemViewPage.external?sp=1000611.
Texte intégralRésumé :
Thesis (MTech. degree in Pharmaceutical Sciences)--Tshwane University of Technology, 2009.Quality control procedures are vital in the pharmaceutical industry to guarantee the authenticity and quality of products. A major challenge in quality assurance of herbal material is the vast variation of active constituents in plants from the same species. As a result of this variation, the selection of only a few compounds as criteria for quality control is inadequate. Pelargonium (P.) sidoides is indigenous to South Africa and highly valued by traditional healers as a remedy to treat coughs, upper respiratory tract irritations and gastrointestinal conditions. An ethanolic extract of P. sidoides is used in the proprietary herbal tincture known as Umckaloabo®. The composition and concentration of polyphenols are parameters which determine the quality of this herbal medicine because it provides several therapeutic benefits in the non-specific medicinal treatment of infectious diseases. Despite the commercial development of P. sidoides very few studies have been conducted to document the full phytochemical range of variation for natural populations and no study has been published on the development of a fast accurate quality control method for the validation of raw material.
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SMAGADI, Aphrodite. « The utilization of natural plant genetic resources and benefit-sharing for the production and legal protection of medicines : the impact of the implementation of the convention on biological diversity ». Doctoral thesis, 2006. http://hdl.handle.net/1814/6597.
Texte intégralRésumé :
Defence date: 14 November 2006Examining board: Prof. Ernst-Ulrich Petersmann (Supervisor, European University Institute) ; Prof. Francesco Francioni (European University Institute) ; Prof. Thomas Cottier (University of Bern, Switzerland) ; Dr. Graham Dutfield (Queen Mary, University of London)
PDF of thesis uploaded from the Library digitised archive of EUI PhD theses completed between 2013 and 2017