Bibliographies thématiques / Peritumoral

Littérature scientifique sur le sujet « Peritumoral »

Auteur : Grafiati
Publié le 14 mars 2023

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Articles de revues sur le sujet "Peritumoral"

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Péley, Gábor, István Sinkovics, József Tóth, Emil Farkas, Sándor Keresztes et István Köves. « Subareolar Injection of Radioactive Colloid for Sentinel Lymph Node Identification in Breast Cancer Patients ». American Surgeon 70, no 7 (juillet 2004) : 625–29. http://dx.doi.org/10.1177/000313480407000713.

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Sentinel lymph node biopsy (SLNB) is becoming the standard for staging the axilla in breast cancer patients in many institutions. The best method of injection is still questionable. The purpose of this study was to compare the results of SLNB using the peritumoral or the subareolar injection site. Between December 1997 and March 2000, we performed 100 SLNBs. Technecium-labeled colloidal human serum albumin was injected peritumorally (Group A, 31 patients; Group B, 31 patients) or subareolarly (Group C, 38 patients). Patent blue dye was given periareolarly (Group A) or peritumorally (Groups B and C). Preoperative lymphoscintigraphy was performed in all patients. SLNB was successful in 94 patients (94%). The identification rate improved from 80 per cent (first 25 patients) to 99 per cent (last 75). The subareolar injection of the colloid did not adversely influence the results of SLNB compared with the peritumoral injection (identification rate, 100% vs 97%; false negative rate, 6% vs 14%). The subareolar injection of colloid is a simple and at least as accurate technique as the peritumoral one. This technique can also improve the identification rate of SLNB for breast cancer patients.
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Mao, Jiaji, Minghui Cao, Fang Zhang, Jingzhong Zhang, Xiaohui Duan, Liejing Lu, Zehong Yang et al. « Peritumoral administration of IFNβ upregulated mesenchymal stem cells inhibits tumor growth in an orthotopic, immunocompetent rat glioma model ». Journal for ImmunoTherapy of Cancer 8, no 1 (mars 2020) : e000164. http://dx.doi.org/10.1136/jitc-2019-000164.

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BackgroundImmunotherapy with IFNβ is a promising strategy for treating malignant glioma. However, systemic administration of IFNβ is inadequate because of low intratumoral concentration and major adverse effects. This study aimed to determine whether mesenchymal stem cells (MSCs) can be used as cellular vehicles to locally deliver IFNβ for glioma therapy by using in vivo MRI tracking.MethodsA recombinant lentiviral vector encoding IFNβ and ferritin heavy chain (FTH) reporter genes was constructed to transduce MSCs. The effectiveness and safety of transduction were assessed. After the IFNβ and FTH overexpressed MSCs (IFNβ-FTH-MSCs) were transplanted into intracranial orthotopic rat F98 gliomas via peritumoral, intracerebral, intratumoral or intra-arterial injection, MRI was performed to track IFNβ-FTH-MSCs and to evaluate their therapeutic effect on glioma in vivo, as validated by histologic analysis, quantitative PCR and ELISA assays.ResultsMSCs were efficiently and safely transduced to upregulate their IFNβ secretion and FTH expression by the constructed lentivirus. After peritumoral injection, IFNβ-FTH-MSCs appeared as hypointense signals on MRI, which gradually diminished but remained visible until 11 days. Compared with other administration routes, only peritumoral injection of IFNβ-FTH-MSCs showed a remarkable inhibition on the glioma growth. Nearly 30% of IFNβ-FTH-MSCs survived up to 11 days after peritumoral injection, while most of IFNβ-FTH-MSCs injected via other routes died within 11 days. IFNβ-FTH-MSCs grafted peritumorally secreted IFNβ persistently, leading to pronounced Batf3+dendritic cells and CD8+T lymphocyte infiltration within the glioma.ConclusionsMSCs can be used as cellular vehicles of IFNβ to treat malignant glioma effectively via peritumoral injection.
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Kanomata, Naoki. « Peritumoral Muciphage ». American Journal of Surgical Pathology 23, no 7 (juillet 1999) : 863. http://dx.doi.org/10.1097/00000478-199907000-00021.

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Lev, Robert, et Giovanni DePetris. « Peritumoral Muciphage ». American Journal of Surgical Pathology 23, no 7 (juillet 1999) : 863. http://dx.doi.org/10.1097/00000478-199907000-00022.

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Vladimirova, Lyubov, Yevgeniya Nepomnyashchaya, Natalya Podzorova, Inna Novikova, Yelena Ulyanova et Nataliya Abramova. « RECOMBINANT TUMOR NECROSIS FACTOR-THYMOSIN-A1 : THE IMPACT ON THE EFFECTIVENESS OF NEOADJUVANT CHEMOTHERAPY AND ANGIOGENESIS IN BREAST CANCER ». Problems in oncology 63, no 1 (1 janvier 2017) : 76–81. http://dx.doi.org/10.37469/0507-3758-2017-63-1-76-81.

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The article covers the results of clinical application of a domestic drug based on recombinant tumor necrosis factor-alpha-thymosin-alpha1 (TNF-T) combined with chemotherapy FAC and РА during neoadjuvant treatment of patients with breast cancer IIB-IIIB stage. In contrast to the standard subcutaneous application method, the authors proposed peritumoral administration of TNF-T to maximize the drug's action directly on the tumor, peritumoral tissue. TNF-T 200000 IU peritumorally on days 1-5 of each treatment course showed significant increase in objective effect rate, including increase in frequency of complete regressions, and decrease in frequency and intensity of chemotherapy complications. Morphological examination revealed an increase rate of medical pathomorphosis grade III-IV, decreased number of microvessels in tumor in comparison with primary tumors
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IKEDA, Yukio, et Kiyoshi MATSUMOTO. « Peritumoral Brain Edema ». Showa University Journal of Medical Sciences 11, no 3 (1999) : 149–54. http://dx.doi.org/10.15369/sujms1989.11.149.

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Stöcklein, R., R. Dorn, H. Vogt, A. Wischnik, J. Sciuk et G. Holl. « Influence of the injection technique on the false negative rate of SLNE in multifocal breast cancer ». Nuklearmedizin 47, no 05 (2008) : 216–19. http://dx.doi.org/10.3413/nukmed-0174.

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Summary Aim: We investigated the influence of the injection technique on the false negative rate in identifying the sentinel lymph node in multifocal breast cancer. Patients, methods: 958 consecutive patients were divided into unifocal and multifocal breast cancer patients. The scintigrafic and intraoperative detection rate as well as the false negatives were calculated in relation to peritumoral or subareolar injection. Results: In all patients the scintigrafic and intraoperative detection rate exceeded 99%, except in patients with multifocal cancer, who were injected peritumorally. In this group the intraoperative detection rate declined to 96%. In patients with unifocal breast cancer the false negative rate was below 5%, independent of the injection technique. Multifocal breast cancer patients showed a significant dependence on the injection technique. The false negative rate was 26.3% in patients with peritumoral injection and 5.6% in those with subareolar injection. Conclusion: The results clearly demonstrate that in multifocal breast cancer a reliable detection of a SLN is impossible with the peritumoral injection technique. Subareolar injection seems to be a way to operate on multifocal breast cancer with SLNE, but the number of investigated patients is too low for statistic approval. So, prospective studies should be performed to validate these preliminary results before SLNE becomes routine in multifocal breast cancer.
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Chen, Jiao, Xianfang Ming, Zhen Wang et Yu Ye. « Analysis of the Performance of Gadoxetic Acid Disodium MRI in Predicting Microvascular Invasion of Hepatocellular Carcinoma ». Contrast Media & ; Molecular Imaging 2022 (28 septembre 2022) : 1–5. http://dx.doi.org/10.1155/2022/6128845.

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Objective. This study aimed to evaluate the predictive value of gadoxetic acid disodium magnetic resonance imaging (MRI) in the microvascular invasion (MVI) of hepatocellular carcinoma (HCC). Methods. 87 HCC patients (2019-01–2022-01) admitted to the hospital were selected for retrospective analysis, gadoxetic acid disodium MRI scan was performed before surgery, and the patients were divided into two groups according to whether the MVI occurred, including the invasion group (n = 47) and the non-invasion group (n = 40). The influencing factors of MVI in HCC patients were explored, independent risk factors were determined, and the correlation between independent risk factors and MVI in HCC patients was analyzed. Results. There were significant differences in tumor margin, peritumoral low signal (hepatobiliary phase), peritumoral enhancement (arterial phase), and peritumoral hyperintensity ring (arterial phase) between the two groups ( P < 0.05 ). Logistic regression analysis showed that unsmooth tumor margin, peritumoral low signal (hepatobiliary phase), peritumoral enhancement (arterial phase), and peritumoral hyperintensity ring (arterial phase) were independent risk factors for MVI in HCC patients ( P < 0.05 ). The results of Spearman correlation analysis showed that unsmooth tumor margin was negatively correlated with MVI in HCC patients (r = −0.66, P = 0.037 ). Moreover, peritumoral low signal (hepatobiliary phase), peritumoral enhancement (arterial phase), and peritumoral hyperintensity ring (arterial phase) were positively correlated with MVI in HCC patients (r1 = 0.63, r2 = 0.68, r3 = 0.72, P 1 = 0.030, P 2 = 0.023, P 3 = 0.017). Conclusion. Unsmooth tumor margin, peritumoral low signal (hepatobiliary phase), peritumoral enhancement (arterial phase), and peritumoral hyperintensity ring (arterial phase) are significantly correlated with MVI in patients with HCC, which can provide a reference for the formulation and implementation of clinical interventions.
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Gao, Xiang, Haiyan Wang, Shanbao Cai, M. Reza Saadatzadeh, Helmut Hanenberg, Karen E. Pollok, Aaron A. Cohen-Gadol et Jinhui Chen. « Phosphorylation of NMDA 2B at S1303 in human glioma peritumoral tissue : implications for glioma epileptogenesis ». Neurosurgical Focus 37, no 6 (décembre 2014) : E17. http://dx.doi.org/10.3171/2014.9.focus14485.

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Object Peritumoral seizures are an early symptom of a glioma. To gain a better understanding of the molecular mechanism underlying tumor-induced epileptogenesis, the authors studied modulation of the N-methyl-d-aspartate (NMDA) receptor in peritumoral tissue. Methods To study the possible etiology of peritumoral seizures, NMDA receptor expression, posttranslational modification, and function were analyzed in an orthotopic mouse model of human gliomas and primary patient glioma tissue in which the peritumoral border (tumor-brain interface) was preserved in a tissue block during surgery. Results The authors found that the NMDA receptor containing the 2B subunit (NR2B), a predominantly extrasynaptic receptor, is highly phosphorylated at S1013 in the neurons located in the periglioma area of the mouse brain. NR2B is also highly phosphorylated at S1013 in the neurons located in the peritumoral area from human brain tissue containing a glioma. The phosphorylation of the extrasynaptic NMDA receptor increases its permeability for Ca2+ influx and subsequently mediates neuronal overexcitation and seizure activity. Conclusions These data suggest that overexcitation of the extrasynaptic NMDA receptors in the peritumoral neurons may contribute to the development of peritumoral seizures and that the phosphorylated NR2B may be a therapeutic target for blocking primary brain tumor–induced peritumoral seizures.
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Dai, Xiao-Meng, Tao Huang, Sheng-Li Yang, Xiu-Mei Zheng, George G. Chen et Tao Zhang. « Peritumoral EpCAM Is an Independent Prognostic Marker after Curative Resection of HBV-Related Hepatocellular Carcinoma ». Disease Markers 2017 (2017) : 1–8. http://dx.doi.org/10.1155/2017/8495326.

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Accumulating evidence suggests that the tumor microenvironment has a profound influence on tumor initiation and progression, opening a new avenue for studying tumor biology. Nonetheless, the prognostic values of the peritumoral expression of EpCAM and CD13 remain to be elucidated in hepatocellular carcinoma (HCC) patients. In this study, the expression of EpCAM and CD13 was assessed by immunohistochemistry in peritumoral liver hepatocytes from 106 hepatitis B virus- (HBV-) related HCC patients who had undergone curative hepatectomy. The peritumoral EpCAM-positive group had a significantly worse overall survival (OS) (p=0.003) and recurrence-free survival (RFS) (p=0.022) compared to the negative group. Peritumoral CD13-positive patients were also associated with poor OS (p=0.038), while not significantly associated with RFS. The adjusted multivariate COX proportional hazard regression analysis suggested that only the positive expression of peritumoral EpCAM precisely predicted poor OS. Being peritumoral EpCAM positive was also significantly associated with a larger tumor size, liver cirrhosis, and more frequent vascular invasion; however, no statistically significant association was observed between CD13 and any clinicopathological features. Taken together, peritumoral EpCAM and CD13 expression was associated with a poor prognosis, but EpCAM may be a better prognostic marker than CD13 in HBV-related HCC patients. In the future, peritumoral EpCAM could be a good target for adjuvant therapy after curative hepatectomy.
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Thèses sur le sujet "Peritumoral"

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Simis, André. « Edema peritumoral em meningiomas benignos : correlação com fatores clínicos, radiológicos, cirúrgicos e com recorrência tumoral ». Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/5/5138/tde-12022008-132122/.

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INTRODUÇÃO: O edema peritumoral (EP) está presente em aproximadamente 60% dos meningiomas. Os fatores responsáveis pela formação do edema e sua importância clínica permanecem como foco de discussão. OBJETIVOS: Analisar a correlação entre a presença de edema com características clínicas, cirúrgicas, radiológicas e recorrência tumoral. MÉTODOS: Foram selecionados 61 pacientes portadores de meningiomas benignos submetidos a tratamento cirúrgico pelo Grupo de Tumores Encefálicos e Metástases do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo. Foram incluídos no estudo os portadores de meningiomas benignos submetidos a ressecção tumoral completa (Simpson 1 e 2). Foram excluídos pacientes portadores de meningiomas malignos ou atípicos e aqueles localizados em tubérculo selar, seio cavernoso, forame magno, intraventriculares e região petroclival. RESULTADOS: Encontramos correlação entre as maiores medidas de edema peritumoral e recorrência tumoral (p = 0,042) e tumores com margens irregulares (p < 0,011) na análise bivariada. Além disso, os pacientes que apresentaram maiores volumes tumorais apresentaram maiores medidas de edema (p = 0,035) e nos pacientes com menores medidas de edema a localização tentorial foi mais freqüente (p = 0,032). Verificamos que ao estudo de regressão logística, o EP apresenta correlação com tumores maiores que 40 cm3 (Odds ratio=15,977), crises convulsivas (Odds ratio=3,469) e para cada cm3 acrescida ao tamanho tumoral o risco de edema cresce 1,082 vez (Odds ratio). CONCLUSÕES: Considerando os resultados obtidos, o EP esteve associado a maior recorrência tumoral, tumores multilobulados, grandes e a presença de crises convulsivas. A localização tentorial mostrou-se como um fator protetor ao EP. O EP pode estar associado a um potencial invasivo aumentado em meningiomas. Desta forma, o seu estudo aprofundado poderá trazer dados adicionais para o esclarecimento dos mecanismos de formação dos meningiomas e de seu comportamento biológico levando ao melhor manejo clínico dos pacientes.
INTRODUCTION: Approximately 60% of meningiomas are associated with peritumoral edema.Various causative factors have been discussed in the literature. PURPOSES: Investigate the correlation of peritumoral edema with clinical, radiological and surgical aspects, and recurrence rate of meningiomas. METHODS: Sixty one benign meningiomas submitted to surgical treatment by the Group of Brain Tumors and Metastasis of the Division of Neurosurgery of the Hospital das Clínicas of São Paulo Medical School of São Paulo University. All patients underwent complete surgical ressection (Simpson 1 and 2) and were excluded the atypical and malignant hystopathological grades. The tumors located in the cavernous sinus, tuberculum sellae region, foramen magnum region, ventricular space and petroclival region were excluded. RESULTS: Edema extention had a positive correlation with the higher recurrence rates (p = 0,042) and with the presence of irregular margins (p < 0,011) on bivariate analysis. Meningiomas with greater edema sizes also showed correlation with large meningiomas (p = 0,035) and the ones with smaller edema sizes correlated with the tentorial location (p=0,032). Multivariate analysis showed an association between peritumoral brain edema and the presence of seizures (Odds ratio=3,469), large meningiomas (Odds ratio=15,977), and for each cubic centimeter added to its size, the risk of edema increased 1,082 times (Odds ratio). CONCLUSION: Peritumoral brain edema correlated with recurrence, irregular margins, seizures and larger tumors. The tentorial location demonstrated smaller edema sizes. Peritumoral brain edema may be related to meningioma\'s invading potentiality and may play a role in the recurrence pontential of the tumor. As a consequence, it\'s reasonable to consider edema\'s presence as an additional factor to be taken into account when arranging layout of strategies for meningiomas treatment.
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Vieira, Fabricio Le Draper. « Tipagem das células do infiltrado inflamatório peritumoral em carcinoma de células escamosas da mucosa bucal : correlação com expressão de Ki67 ». Universidade do Estado do Rio de Janeiro, 2009. http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=4554.

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O emprego de técnicas imunoistoquímicas, utilizando marcadores biológicos como o Ki67, que permite a avaliação do índice de proliferação celular em neoplasias malignas, vem sendo preconizado como um importante caminho de investigação do comportamento biológico das neoplasias malignas, tendo como consequências contribuições para o estabelecimento do prognóstico e desenvolvimento de novos protocolos terapêuticos. Neste trabalho, utiliza-se o método imunoistoquímico da avidina-biotina-peroxidase avaliada a expressão de Ki67 no parênquima de amostras de carcinomas de células escamosas da mucosa bucal com diferentes graus de diferenciação histológica. Além disso, a quantificação da área de infiltrado inflamatório foi avaliada. Os resultados demonstraram que a resposta imunológica celular é o principal mecanismo de defesa no carcinoma de células escamosas da mucosa bucal, expressada pelo grande número de linfócitos T e macrófagos e a expressão de Ki67 está relacionado ao índice mitótico e, consequentemente, à proliferação celular e, também, à diferenciação da neoplasia.
The utilization of immunohistochemical techniques as biological markers, such as Ki67, that allows the evaluation of the cell proliferation in malignancies, has been advocated as an important way of investigating the biological behavior of cancer, resulting in contributions to the establishment of prognosis and development of new treatment protocols. In this study, using immunohistochemical methods with avidin-biotin-peroxidase, we have assessed the expression of Ki67 in samples of oral squamous cell carcinoma with different patterns of histologic differentiation. The results showed that the cellular immune response is the major deffence mechanisnc in squamous cell carcinoma of the oral mucosa, expressed by the large number of T lymphocytes and macrophages, and expression of Ki67 is related to mitotic index associated with cell proliferation and neoplastic differentiation of tumor.
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Silva, Júlio César Thomé de Souza. « Correlação da localização topográfica e do edema peritumoral em pacientes com glioma recidivo com a resposta terapêutica ao álcool perílico ». Niterói, 2010. https://app.uff.br/riuff/handle/1/4846.

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Universidade Federal Fluminense. Hospital Universitário Antonio Pedro
Hospital Federal de Ipanema
Hospital Municipal Souza Aguiar
Introdução: Gliomas são tumores cerebrais primários caracterizados pelo crescimento difuso e invasivo. Estudo biomatemático de proliferação e migração dos gliomas propõe que o crescimento de tumores na substância cinzenta profunda cerebral teria um intervalo de tempo maior comparado a lesões situadas na substância branca lobar, onde a invasão e migração seriam mais rápidas. Objetivo: Estabelecer uma correlação da topografia tumoral e edema peritumoral com a resposta terapêutica à administração intranasal do álcool perílico (AP) em pacientes com glioblastoma (GBM) recidivo após tratamento convencional. Métodos: A coorte incluiu o estudo retrospectivo de 119 pacientes com glioma recidivo, sendo 52 em tratamento paliativo de suporte (grupo controle não pareado) e 67 que foram incluídos no Estudo Fase I/II do álcool perílico e receberam administração pela via inalatória de 440 mg de AP diariamente durante o período de Janeiro 2005 a Dezembro 2009. Os parâmetros avaliados incluíram aspectos clínicos e de neuroimagem: topografia tumoral, volume tumoral, presença de desvio da linha média e extensão de edema peritumoral; análise dos dados demográficos, sintomas iniciais e sobrevida global. Análise estatística foi realizada usando testes log rank. A sobrevida global foi determinada pelo método de Kaplan-Meier, incluindo intervalos de confiança de 95%. Resultados: Pacientes do grupo controle apresentaram sobrevida reduzida (p < 0,0001) em relação ao grupo tratado com AP. Dentre os 67 pacientes com GBM, 14 (21%) apresentavam localização talâmica e 53 (79%) localização lobar. Pacientes com tumor localizado na região do tálamo sobreviveram significativamente mais tempo do que aqueles com tumor localizado na região lobar (log rank test, p = 0,0003). Pacientes que apresentaram regressão tumoral acompanhada de redução do edema peritumoral apresentaram resposta clínica positiva, enquanto aqueles com regressão tumoral sem redução do edema peritumoral apresentaram evolução clínica desfavorável, independentemente da topografia tumoral. Presença de desvio da linha média (> 1 cm) foi estatisticamente significante como fator de risco para menor sobrevida (log rank test, p = 0,0062). Conclusões: Este estudo sugere que: (1) pacientes com tumor localizado na região profunda (tálamo) apresentaram sobrevida média maior do que pacientes com tumor localizado na região lobar; (2) edema peritumoral foi um fator determinante na sintomatologia, provavelmente implicado na morbidade podendo estar relacionado com a característica de invasividade do glioma maligno. Esses achados apóiam a teoria de que fatores presentes em diferentes microambientes do tecido cerebral (tálamo, córtex) possam contribuir para o processo de progressão tumoral, para o prognóstico clínico e a resposta terapêutica ao álcool perílico administrado pela vias inalatória
Introduction: Gliomas are primary brain tumors are characterized by diffuse and invasive growth. Study biomathematical proliferation and migration of gliomas suggests that the growth of tumors in deep brain gray matter would have a longer time interval compared with lesions in the lobar white matter, where the invasion and migration would be faster. Objective: To establish a correlation of peritumoral edema and tumor topography with the therapeutic response to intranasal administration of perillyl alcohol (PA) in patients with glioblastoma (GBM) relapsing after conventional treatment. Methods: The cohort included a retrospective study of 119 patients with relapsing glioma, 52 palliative care support (control group) and 67 that were included in the Study Phase I / II and received perillyl alcohol administration by inhalation of 440 mg AP daily during the period January 2005 to December 2009. The parameters evaluated included clinical and neuroimaging: topography tumor, tumor volume, presence of midline shift and extent of peritumoral edema, analysis of demographic data, initial symptoms and overall survival. Statistical analysis was performed using log rank tests. Overall survival was determined by Kaplan-Meier, including 95% confidence intervals. Glioma is a primary brain tumor characterized by diffuse growth and invasiveness. The pattern of differential tumor growth and invasiveness suggest that patients with tumoral lesion located in the lobar white matter region present lower survival rate than patients with lesion located in deep brain gray matter (thalamo). Objective: To establish a correlation between tumor topography and peritumoral edema with the therapeutic response to intranasal administration of perillyl alcohol (POH). Methods: This retrospective study analyzed 119 patients with recurrent glioma being 52 under supportive treatment (control group) and 67 included in the Phase I/II clinical trial that received intranasal administration of 440 mg daily AP from January 2005 to December 2009. The following parameters were analyzed: clinical assessment; demographic data, symptoms and overall survival, neuroimage analysis of topography including tumor volume, midline shift and extent of peritumoral edema. Statistical analysis was performed using log rank tests. The overall survival was determined by the Kaplan-Meier method, including 95% confidence intervals. Results: Patients from control group showed reduced overall survival (p < 0,0001) in comparison with patients included in the Phase I/II that received treatment with perillyl alcohol. Among 67 GBM patients, 14 (21%) had tumoral lesion in the thalamic region and 53 (79%) in the lobar region. Patients with thalamic tumor survived significantly longer than those with tumor located in the lobar region (log rank test, p = 0.0003). Patients with tumor regression with reduction of peritumoral edema had positive clinical response, whereas poor prognosis was observed in those with tumor regression but without reduction of peritumoral edema. Presence of midline shift (> 1 cm) was statistically significant as a risk factor for shorter survival (log rank test, p = 0062). Conclusions: This study indicates that: 1) patients with tumoral lesion in the deep region (thalamic) have longer overall survival than GBM patients with tumors in the lobar region; 2) presence of peritumoral edema contributes strongly to symptoms and is likely to influence morbidity and the invading potential of malignant glioma. These findings support the hypothesis that interaction between glioma cells and different brain microenvironment (thalamo, cortex) can influence the process of glioma progression, clinical prognosis and therapeutic response to intranasal delivery perillyl alcohol
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Grochot, Rafael Maciel. « Expressão do PD-L1 em neoplasias cervicais e seu impacto em sobrevida associado à infiltração linfocitária peritumoral e à expressão de FOXP3 ». reponame:Repositório Institucional da UCS, 2018. https://repositorio.ucs.br/11338/3902.

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Mendes, Suzanny Oliveira. « Perfil da expressão de HIF-1α em células linfoides do infiltrado inflamatório peritumoral e intratumoral como marcador prognóstico do carcinoma epidermoide de cavidade oral ». reponame:Repositório Institucional da UFES, 2014. http://repositorio.ufes.br/handle/10/1887.

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O complexo transcricional HIF-1 é responsável por controlar a transcrição de mais de 100 genes envolvidos em resposta celular a hipóxia. A subunidade HIF-1α é estabilizada em condições de hipóxia e dimeriza-se com um a subunidade HIF-1β, formando o complexo HIF-1 transcricionalmente ativo. Em células inflamatórias, uma elevada expressão de HIF-1α pode induzir os linfócitos à imunossupressão, reduzindo o reconhecimento dos antígenos tumorais, permitindo o crescimento tumoral. O presente trabalho objetivou investigar a relação entre a expressão de HIF-1α em linfócitos do infiltrado inflamatório intratumoral e peritumoral de 56 pacientes com carcinoma epidermoide de cavidade oral. Os resultados indicaram um valor prognóstico para esta expressão. Uma elevada expressão da HIF-1α em células do infiltrado inflamatório peritumoral foi significantemente relacionada com o pior prognóstico do paciente, enquanto esta elevada expressão nos linfócitos na região intratumoral foi correlacionado com um melhor prognóstico. Um perfil de risco indicando a chance para a recidiva e óbito foi desenhado baseado na expressão de HIF-1α nos linfócitos do infiltrado inflamatório peritumoral e intratumoral, definindo os riscos baixo, intermediário e alto. Este perfil de risco foi hábil para determinar que a expressão forte de HIF-1α nos linfócitos peritumorais são relacionados com um pior prognóstico, independente da expressão nas células intratumorais. A expressão fraca de HIF-1α nos linfócitos peritumorais e forte nos linfócitos intratumorais foram considerados um perfil de baixo risco, mostrando nenhum caso de recidiva da doença e óbito decorrente da doença. O risco intermediário foi associado com baixa expressão de HIF-1α tanto em infiltrado inflamatório intratumoral como peritumoral. Estes resultados sugerem que a expressão da HIF-1α em células linfoides do infiltrado inflamatório intratumoral e peritumoral pode exercer um papel importante como um marcador prognóstico tumoral.
The HIF-1 transcriptional complex is responsible for controlling transcription of over 100 genes involved in cell hypoxia response. HIF-1α subunit is stabilized in hypoxia conditions, dimerizes with HIF-1β forming the active HIF-1 transcriptional factor. In inflammatory cells, high HIF-1α expression might induce lymphocytic immunosuppression, decreasing tumoral antigen recognition, allowing tumor growth. The present work aimed to investigate the relationship between HIF-1α expression in lymphocytes inflammatory infiltrate from intratumoral and peritumoral region of 56 patients with oral cancer. Data indicates a prognostic value for this expression. High HIF-1α expression in peritumoral inflammatory cells was significantly related to worse patient outcome, whereas high expression in the intratumoral lymphoid cells correlates with a better prognosis. A risk profile indicating the chance of disease relapse and death was designed based on HIF-1α expression in inflammatory infiltrate cells, defining low, intermediate and high risks. This risk profile was able to determine that high HIF-1α expression in peritumoral lymphocytes correlates with worse prognosis, independently of intratumoral inflammatory infiltrate expression. Low HIF-1α in peritumoral lymphocytes and high expression in the intratumoral lymphocytes was considered a low risk profile, showing no cases of disease relapse and disease related death. Intermediate risk was associated with low HIF-1α expression in inflammatory infiltrate intratumoral and peritumoral. in tumor and tumor margins. These results suggest that HIF-1α expression in tumor and peritumoral inflammatory cells may play an important role as prognostic tumor marker.
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MENDES, S. O. « Perfil da Expressão de Hif-1 Alfa em Células Linfoides do Infiltrado Inflamatório Peritumoral e Intratumoral Como Marcador Prognóstico do Carcinoma Epidermoide de Cavidade Oral ». Universidade Federal do Espírito Santo, 2014. http://repositorio.ufes.br/handle/10/4481.

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O complexo transcricional HIF-1 é responsável por controlar a transcrição de mais de 100 genes envolvidos em resposta celular a hipóxia. A subunidade HIF-1α é estabilizada em condições de hipóxia e dimeriza-se com um a subunidade HIF-1β, formando o complexo HIF-1 transcricionalmente ativo. Em células inflamatórias, uma elevada expressão de HIF-1α pode induzir os linfócitos à imunossupressão, reduzindo o reconhecimento dos antígenos tumorais, permitindo o crescimento tumoral. O presente trabalho objetivou investigar a relação entre a expressão de HIF-1α em linfócitos do infiltrado inflamatório intratumoral e peritumoral de 56 pacientes com carcinoma epidermoide de cavidade oral. Os resultados indicaram um valor prognóstico para esta expressão. Uma elevada expressão da HIF-1α em células do infiltrado inflamatório peritumoral foi significantemente relacionada com o pior prognóstico do paciente, enquanto esta elevada expressão nos linfócitos na região intratumoral foi correlacionado com um melhor prognóstico. Um perfil de risco indicando a chance para a recidiva e óbito foi desenhado baseado na expressão de HIF-1α nos linfócitos do infiltrado inflamatório peritumoral e intratumoral, definindo os riscos baixo, intermediário e alto. Este perfil de risco foi hábil para determinar que a expressão forte de HIF-1α nos linfócitos peritumorais são relacionados com um pior prognóstico, independente da expressão nas células intratumorais. A expressão fraca de HIF-1α nos linfócitos peritumorais e forte nos linfócitos intratumorais foram considerados um perfil de baixo risco, mostrando nenhum caso de recidiva da doença e óbito decorrente da doença. O risco intermediário foi associado com baixa expressão de HIF-1α tanto em infiltrado inflamatório intratumoral como peritumoral. Estes resultados sugerem que a expressão da HIF-1α em células linfoides do infiltrado inflamatório intratumoral e peritumoral pode exercer um papel importante como um marcador prognóstico tumoral.
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Makdissi, Fabiana Baroni Alves. « "Análise da expressão de E-caderina, Snail e Hakai em células epiteliais de tumor e tecido peritumoral de mulheres com carcinoma ductal invasivo da mama : correlação com comprometimento linfonodal" ». Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/5/5155/tde-07082006-110753/.

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A expressão de E-caderina (Ecad) pode ser regulada pré ou pós transcricionalmente por Snail e Hakai, respectivamente. Nosso objetivo foi determinar a expressão de Ecad, Snail e Hakai, em células epiteliais (CE) de tecido tumoral e peritumoral de pacientes com carcinoma ductal invasivo da mama e correlacionar sua expressão ao comprometimento linfonodal axilar (LN+). As CE de amostras de tecidos de 45 pacientes (52% LN+) foram extraídas por método imunomagnético, o RNA foi extraído por RT-PCR em tempo real e utilizou-se primers específicos para a moléculas. A expressão de Ecad, Snail e Hakai não variou entre o tecido tumoral e peritumoral e não houve correlação com comprometimento linfonodal
E-cadherin (Ecad) expression may be transcriptionally or post-transcriptionally regulated by Snail and Hakai. Our aim was to determine the expression of Ecad, Snail and Hakai, in epithelial cells (EC) obtained from tumor and its adjacent tissue from women with invasive ductal breast carcinoma (IDC) and evaluate their correlation to the axillary's lymph node (LN+) involvement. Tissue from 45 patients (52% LN+) had their EC recovered by immunomagnetic antibody process, RNA was extracted and real-time RT-PCR was performed using specific primers. Ecad, Snail and Hakai mRNA expression did not vary between tumoral and peritumoral samples and their expression was not correlated to LN involvement
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GIANNICE, RAFFAELLA. « Il microambiente peritumorale nel carcinoma dell'endometrio ». Doctoral thesis, Università degli Studi di Milano-Bicocca, 2012. http://hdl.handle.net/10281/31294.

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INTRODUZIONE Sempre maggiori evidenze scientifiche confermano che il microambiente peri tumorale gioca un ruolo importante nello sviluppo e nel comportamento dei tumori solidi. Nelle ultime decadi la correlazione tra tumore e risposta infiammatoria peritumorale è stata ampiamente accettata indicando il ruolo centrale del sistema immunitario nella progressione tumorale e nella prognosi. Obiettivo primario dello studio è stato analizzare l’espressione dell’mRNA di alcune citochine, chemochine e loro recettori e di alcuni fattori di crescita, estratti da campioni di carcinoma originato da endometrio umano e confrontarli con l’ mRNA estratto da campioni di tessuto endometriale normale omologo al fine di caratterizzare le variazioni del microambiente tumorale del carcinoma endometriale rispetto al tessuto endometriale sano. L’obiettivo secondario è stato evidenziare i fattori più interessanti presenti nell’ambiente peritumorale del carcinoma endometriale per programmare uno studio prospettico con una casistica maggiore. MATERIALE E METODO. Presso l’istituto Clinico di Ricerca a Carattere Scientifico IRCCS Humanitas di Rozzano, da pazienti sottoposte a chirurgia primaria per carcinoma dell’endometrio, sono stati prelevati: un campione di carcinoma endometriale (A) e un campione da tessuto endometriale sano della stessa paziente (B) trattati con RNA later e conservati a –80°C. I parametri clinici e chirurgici sono stati raccolti. L’RNA è stato estratto, quantificato, retrotrascritto in cDNA ed infine quantificato mediante una RQ-PCR. RISULTATI. Dodici pazienti con carcinoma endometriale sono state arruolate nello studio. Nel tessuto tumorale endometriale umano, rispetto al tessuto di controllo sano, sono state osservate i risultati statisticamente significativi che seguono. Un’inibizione del CXCL12 mRNA nelle pazienti con infiltrazione del miometrio > 50% (P= .003). Il CXCL12 era direttamente correlato a quello del CXCR7 nel 100% dei casi (P=0.000). L’mRNA del TNF è risultato down-regolato nel 67% dei casi, ed in particolare, nel 100% delle pazienti in cui l’invasione miometriale era > 50% versus il 50% delle pazienti con infiltrazione del miometrio < 50% (P<.09) . Un basso livello di espressione dell’mRNA dell’ IL6 è stato evidenziato nel 100% degli stadi avanzati versus il 45% degli stadi iniziali nel tessuto tumorale rispetto al tessuto sano, (P< .05). Il MIF mRNA aveva un’ aumentata espressione nel 100% dei casi, (P<.001). L’up-regolazione del MIF mRNA era indirettamente proporzionale a quella del TGFb (P<.05). CONCLUSIONI. In base ai risultati di questo studio, tutti i fattori dell’ambiente peritumorale del carcinoma endometriale esaminati hanno dimostrato livelli di espressione interessanti e meritevoli di approfondimento. Tutti potrebbero essere presi in considerazione quali nuovi target di terapia antitumorale per prolungare l’intervallo libero da malattia o addirittura portare alla guarigione, mediante l’utilizzo di farmaci o anticorpi bloccanti soprattutto nei pazienti a rischio medio-alto ma con stadio del tumore ancora precoce. Il dosaggio dei fattori di crescita, citochine e chemochine esaminati nel nostro studio potrebbe essere utilizzato anchecome fattore prognostico per il tipo di terapia adiuvante, soprattutto negli stadi iniziali. Questi risultati, anche se devono essere confermati in una popolazione piu’ ampia e con un FU maggiore, forniscono un evidenza scientifica che individua nuovi obiettivi per la terapia anti-tumorale per il futuro.
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Lemée, Jean-Michel. « Au delà des frontières du glioblastome : caractérisation de la zone péritumorale des glioblastomes ». Thesis, Angers, 2015. http://www.theses.fr/2015ANGE0001/document.

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Le glioblastome (GB) est une tumeur hétérogène, agressive devant laquelle les possibilités thérapeutiques disponibles restent limitées. L’étude de la zone péritumorale macroscopiquement normale (ZMN) des GB est essentielle à la compréhension de ses mécanismes de progression et de récidive. Le premier objectif de ce travail de Thèse a été de comparer les données de transcriptomique et de protéomique issues de l’analyse de la zone tumorale des GB dans le cadre du Projet Gliome Grand Ouest. Le taux de concordance entre les 2 modalités est faible, retrouvant toutefois comme point commun une dysrégulation de la protéine légère des neurofilaments qui pourrait servir de biomarqueur potentiel des GB. Le deuxième objectif de ce travail de Thèse a été la caractérisation de la ZMN des GB. Nous avons mis en évidence que cette zone, dont l’aspect est similaire à première vue à celui du tissu cérébral sain, n’est pas une simple zone de transition entre le GB et le tissu cérébral sain. En effet, la ZMN est une entité spécifique possédant des caractéristiques qui lui sont propres, comme la présence d’un phénotype particulier de cellules tumorales infiltrantes et de cellules stromales et une sur’expression des protéines CRYAB et H3F3A. Ce travail de Thèse a aussi été l’occasion de développer de nouvelles techniques d’imagerie per-opératoire de la ZMN, afin d’évaluer la présence d’un contingent tumoral et ainsi optimiser la qualité de la résection chirurgicale. La caractérisation de cette ZMN nous permet de mieux appréhender son implication dans la tumorogenèse et la présence de caractéristiques spécifiques de cette zone ouvre la porte à la détection de biomarqueurs spécifiques, ainsi qu’au développement de thérapies ciblées. Ce travail de Thèse a été valorisé par 2 publications, 2 articles soumis et un brevet est en cours de dépôt et d’évaluation par un cabinet de brevet
Glioblastoma (GB) is a heterogeneous andaggressive tumor, before which therapeutic options arelimited. The study of the macroscopically normalperitumoral brain zone (PBZ) of GB is essential tounderstand its mechanisms of progression andrecurrence.The first objective of this thesis work was tocompare the transcriptomic and proteomic data from theGB tumor area obtained through the “Grand Ouest”glioma Project. The concordance rate between the 2modalities is low. However, one of the common featureis the dysregulation of neurofilament light polypeptide,which could serve as a biomarker potential of GB.The second objective of this thesis was thecharacterization of the PBZ. We have shown that thisarea, similar at first glance to that of healthy braintissue, is not a simple transition area between the GBand healthy brain tissue but a specific entity withcharacteristics of its own. For example, the ZMNpresents a particular phenotype of infiltrating GB cellsand stromal cells and a surexpression of CRYAB andH3F3A proteins.This thesis work was also an opportunity todevelop new intraoperative imaging techniques of thePBZ, with the aim to assess the presence of a tumoralinfiltration and optimize the quality of the surgicalresection.The characterization of this PBZ allows us tobetter understand its involvement in tumorigenesis andthe presence of specific characteristics of this areaopens the door for the detection of specific biomarkersand the development of targeted therapies.This thesis work was led to 2 publications, 2articles submitted and a patent being evaluated andredacted by a patent office
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Sarraf, Michel. « Evaluation non-invasive des Gliomes par Imagerie Résonance Magnétique : Effets des traitements anti-angiogéniques (Avastin) sur la microvascularisation et la microarchitecture tumorale et péritumorale ». Thesis, Université Grenoble Alpes (ComUE), 2019. http://www.theses.fr/2019GREAS040.

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En neuro-oncologie, les effets des traitements anti-angiogéniques utilisés pour inhiber la microvascularisation tumorale ne sont pas bien maîtrisés, comme dans le cas des glioblastomes traités par Avastin. Seulement une partie des patients montre une réponse significative au traitement. L’imagerie conventionnelle anatomique ne permet pas d’évaluer l’efficacité de ce traitement. Le défi est de trouver et valider des nouveaux biomarqueurs capables de prédire la réponse tumorale précocement. L’objectif principal de cette thèse est de développer et de mettre en place un protocole préclinique d’imagerie par résonance magnétique (IRM) multiparamétrique, qui est capable de caractériser et de suivre précocement l’évolution après traitement par l’Avastin : la microvascularisation et des microstructures dans la tumeur et sa région péritumorales. Dans ce but, la quantification du volume sanguin (VS), du Kmodel (i.e coefficient apparent d’accumulation de l’agent de contraste (AC)) et l’évaluation de la microarchitecture par la technique d’IRM de diffusion DTI ont été développées et évaluées comme biomarqueurs.Dans un premier temps, nous avons développé et mis en place la méthode Rapid Steady State T1 (RSST1) pour la quantification du VS et du Kmodel dans la tumeur où l’AC s’extravase. Cette technique a été développée initialement pour quantifier le volume sanguin en l’absence d’extravasation de l’AC. Le développement ainsi effectué durant ma thèse repose sur la modélisation du signal d’extravasation RSST1 par un modèle mathématique qui prend en compte l’échange bi-compartimental et unidirectionnel de l’AC du compartiment vasculaire vers le compartiment extravasculaire. Ce développement a permis de quantifier les paramètres vasculaires dans le cas du gliome C6 chez le rat. Les résultats ont été confirmés par d’autres modalités d’imagerie (Technique stationnaire de susceptibilité magnétique et par histologie).Dans un second temps, nous avons étudié la sensibilité de la méthode RSST1 pour le suivi de la réponse tumorale à traitement antiangiogénique dans des conditions proches de la clinique. Pour cette étude, le modèle du gliome humain U87 MG a été utilisé chez la souris sous traitement par Avastin. La méthode RSST1 s’est avérée reproductible pour la mesure du VS et plus sensible que l’imagerie pondérée T1 (avec injection du Gd-DOTA comme AC, T1w-Gd-DOTA) pour détecter et pour suivre la réponse tumorale à l’Avastin notamment à des stades précoces de la progression tumorale. Nos résultats concernant la mesure du VS ont été corrélés aux mesures effectuées par la microscopie à deux photons.Enfin, dans la dernière partie de cette thèse nous avons étudié la capacité de l’imagerie du tenseur de diffusion (DTI), couplée à l’IRM de type FLAIR (fluid-attenuated inversion recovery) et T1w-Gd-DOTA, pour caractériser les régions tumorales, péritumorales et controlatérales dans le modèle U87MG. La quantification des paramètres DTI nous a permis d’évaluer les changements des microstructures dans la région peritumorale avant et pendant l’invasion cellulaire provoquée par l’Avastin pour différents modes d’administration : intraveineux, intratumoral par convection-enhanced delivery. La délinéation des régions péritumorales a été basée sur les images anatomiques, mais nous avons aussi pris en compte la progression intrinsèque de chaque tumeur. Une différence significative des paramètres DTI a été détectée entre les régions tumorales, péritumorales et controlatérales et une évolution différente de ces paramètres a été constatée selon le mode d’injection de l’Avastin
In neuro-oncology, the effects of anti-angiogenic treatments are not predictable, as observed in glioblastomas treated with Avastin. Only a minority of patients show a significant response to treatment. Conventional imaging modalities are not able to evaluate the efficiency in the early phase of the treatment. Thus, the challenge remains to find and to validate new biomarkers that are able to predict the early response to such therapies.The aim of this work is to develop and implement a preclinical multiparametric magnetic resonance imaging (MRI) protocol for the characterization and follow up of early microvascular and microstructural changes in the tumor and its peritumoral regions after treatment with Avastin. For this purpose, the quantification of the blood volume and Kmodel (an apparent coefficient that is related to the contrast agent (CA) uptake rate), and evaluation of brain microarchitecture by diffusion tensor imaging were developed and evaluated as biomarkers.The Rapid Steady State T1 (RSST1) method was initially developed for blood volume quantification in the absence of CA extravasation. In the first part of this thesis, we have implemented and adapted this MRI technique for the quantification of both blood volume and Kmodel in tumors where the CA extravasates. We developed a mathematical model for the RSST1 signals that accounts for the unidirectional bi-compartmental exchange of CA from the vascular towards the extravascular compartment. This development allows to the quantification of vascular parameters in a rat glioma model (C6). The results were confirmed using another MRI modality, the steady state magnetic susceptibility method, and quantitative histology.In the second part, we studied the sensitivity of the RSST1 method for the follow up of the glioma response to anti-angiogenic treatment under clinical conditions. In this study, the effect of Avastin treatment in a murine orthotopic U87 MG glioma model was analyzed. The RSST1 method demonstrated a high reproducibility in the blood volume quantification and a superior sensitivity in comparison to CA enhanced T1-weighted imaging (T1W-Gd-DOTA) for the detection and follow-up of the tumor response to Avastin, especially in early stages of tumor progression. Blood volume quantification by MRI was correlated to measures obtained by two-photon microscopy.In the last part of this thesis, we have studied the capacity of diffusion tensor imaging (DTI) coupled with FLAIR (fluid-attenuated inversion recovery) MRI and T1w-Gd-DOTA, to characterize tumor, peritumoral, and contralateral regions of the U87MG glioma model. We quantified DTI parameters before and during the invasion of tumor cells induced by Avastin in the peritumoral zone for different administration modes: intravenous and intratumoral via Convention-Enhanced Delivery. Therefore, the delineation of peritumoral regions for each tumor in an early stage was based on anatomical images, that took into account the individual tumor progression at later stages. Significant differences were detected for DTI parameters between the tumor, peritumoral, and contralateral regions and a different evolution of these parameters was noticed according to the Avastin injection mode
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Livres sur le sujet "Peritumoral"

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Cherdanceva, Tat'yana, Vladimir Klimechev et Igor' Bobrov. Pathological and molecular biological analysis of renal cell carcinoma. Diagnosis and prognosis. ru : INFRA-M Academic Publishing LLC., 2020. http://dx.doi.org/10.12737/1020785.

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The monograph is devoted to the study of pathomorphological and molecular-biological characteristics of renal cell carcinoma and peritumoral zone depending on the degree of malignancy, and determine prognostic significance of criteria for predicting the postoperative survival of patients. Of interest to urologists, oncologists, pathologists, researchers, graduate students, dealing with the diagnosis of renal cell carcinoma and subsequent prediction of postoperative survival of patients.
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Hatef, Jeffrey, et Russell R. Lonser. Hemangioblastoma. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190696696.003.0007.

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Hemangioblastomas are benign central nervous system tumors that are found primarily (99%) in the cerebellum, brainstem, and spinal cord. They can occur sporadically (67% of cases) or in the context of the familial neoplasia syndrome, von Hippel-Lindau disease (VHL; 33%). These lesions often remain quiescent or grow in a saltatory pattern. When these tumors cause signs or symptoms, the signs or symptoms are often associated with peritumoral cyst formation. Whether the tumor occurs sporadically or in the context of VHL, complete resection is the treatment of choice when necessary. This chapter describes the clinical, imaging, and treatment features of this neoplasm.
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Woolf, Eric C., et Adrienne C. Scheck. Ketogenic Diet as Adjunctive Therapy for Malignant Brain Cancer. Sous la direction de Jong M. Rho. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780190497996.003.0013.

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Malignant brain tumors are devastating, and increased survival requires new therapeutic modalities. Metabolic dysregulation results in an increased need for glucose in tumor cells, suggesting that reduced tumor growth could be achieved with decreased glucose availability either through pharmacological means or use of a high-fat, low-carbohydrate ketogenic diet (KD). KD provides increased blood ketones to support energy needs of normal tissues and has been shown to reduce tumor growth, angiogenesis, inflammation, peritumoral edema, migration, and invasion. Furthermore, this diet can enhance the activity of radiation and chemotherapy in a mouse model of glioma, thus increasing survival. In vitro studies indicate that increasing ketones in the absence of glucose reduction can also inhibit cell growth and potentiate the effects of radiation. Thus, emerging data provide strong support for the use of KD in the treatment of malignant gliomas and thus far has led to a limited number of clinical trials.
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Chapitres de livres sur le sujet "Peritumoral"

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Chang, Han Soo. « Peritumoral Edema ». Dans Meningiomas, 565–71. London : Springer London, 2009. http://dx.doi.org/10.1007/978-1-84628-784-8_60.

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Bradač, Gianni Boris, Ron Ferszt et Brian E. Kendall. « Peritumoral Oedema in Meningiomas ». Dans Cranial Meningiomas, 120–28. Berlin, Heidelberg : Springer Berlin Heidelberg, 1990. http://dx.doi.org/10.1007/978-3-642-72581-4_13.

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Kawamura, Atsufumi, T. Nagashima, K. Fujita et N. Tamaki. « Peritumoral Brain Edema Associated with Pediatric Brain Tumors : Characteristics of Peritumoral Edema in Developing Brain ». Dans Brain Edema IX, 381–83. Vienna : Springer Vienna, 1994. http://dx.doi.org/10.1007/978-3-7091-9334-1_103.

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Gröger, U., P. Huber et H. J. Reulen. « Formation and Resolution of Human Peritumoral Brain Edema ». Dans Brain Edema IX, 373–74. Vienna : Springer Vienna, 1994. http://dx.doi.org/10.1007/978-3-7091-9334-1_100.

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Ide, Mitsunobu, M. Jimbo, O. Kubo, M. Yamamoto, E. Takeyama et H. Imanaga. « Peritumoral Brain Edema and Cortical Damage by Meningioma ». Dans Brain Edema IX, 369–72. Vienna : Springer Vienna, 1994. http://dx.doi.org/10.1007/978-3-7091-9334-1_99.

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Gutwald, J., W. Groth et G. Mahrle. « Erste Ergebnisse mit peritumoral injiziertem I1-2 beim Melanom ». Dans Operative Dermatologie, 65–67. Berlin, Heidelberg : Springer Berlin Heidelberg, 1995. http://dx.doi.org/10.1007/978-3-642-79468-1_12.

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Shirotani, Toshiki, K. Shima et H. Chigasaki. « Resolution of Peritumoral Brain Edema Following Excision of Meningioma ». Dans Brain Edema IX, 416–18. Vienna : Springer Vienna, 1994. http://dx.doi.org/10.1007/978-3-7091-9334-1_113.

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Ito, Umeo, H. Tomita, O. Tone, H. Masaoka et B. Tominaga. « Peritumoral Edema in Meningioma : a Contrast Enhanced CT Study ». Dans Brain Edema IX, 361–64. Vienna : Springer Vienna, 1994. http://dx.doi.org/10.1007/978-3-7091-9334-1_97.

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Ould Ismail, Abdol Aziz, Drew Parker, Moises Hernandez-Fernandez, Steven Brem, Simon Alexander, Ofer Pasternak, Emmanuel Caruyer et Ragini Verma. « Characterizing Peritumoral Tissue Using DTI-Based Free Water Elimination ». Dans Brainlesion : Glioma, Multiple Sclerosis, Stroke and Traumatic Brain Injuries, 123–31. Cham : Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-11723-8_12.

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Ikeda, Y., et S. Nakazawa. « Peritumoral Edema : Analysis of CT Scan and Dynamic CT Scan ». Dans Brain Edema, 479–83. Berlin, Heidelberg : Springer Berlin Heidelberg, 1985. http://dx.doi.org/10.1007/978-3-642-70696-7_72.

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Actes de conférences sur le sujet "Peritumoral"

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Campos, Ingrid, Paulo de Aguiar, Ingrid Campos, Cassiano Marchi et Fábio Nakazone. « Edema cerebral peritumoral em glioblastoma ». Dans XXXII Congresso Brasileiro de Neurocirurgia. Thieme Revinter Publicações Ltda, 2018. http://dx.doi.org/10.1055/s-0038-1672376.

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Yashin, Konstantin S., Ksenia A. Achkasova, Alexander A. Moiseev, Elena B. Kiseleva, Evgenia L. Bederina, Anna A. Epishkina, Anton Y. Ermolaev, Igor A. Medyanik, Elena V. Zagaynova et Natalia D. Gladkova. « Quantification of peritumoral white matter damage using cross-polarization OCT ». Dans Clinical and Translational Neurophotonics 2021, sous la direction de Victor X. D. Yang et Jana M. Kainerstorfer. SPIE, 2021. http://dx.doi.org/10.1117/12.2578274.

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Pilones, Karsten, Silvia Formenti et Sandra Demaria. « Abstract 1416 : Peritumoral IL-15 potentiates radiation-induced anti-tumor immunity ». Dans Proceedings : AACR 107th Annual Meeting 2016 ; April 16-20, 2016 ; New Orleans, LA. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.am2016-1416.

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Karwat, Piotr, Ziemowit Klimonda, Hanna Piotrzkowska-Wroblewska, Katarzyna Dobruch-Sobczak et Jerzy Litniewski. « Quantitative ultrasound examination of peritumoral tissue improves classification of breast lesions ». Dans 2019 IEEE International Ultrasonics Symposium (IUS). IEEE, 2019. http://dx.doi.org/10.1109/ultsym.2019.8925988.

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Trivedi, Megh, Alankrita Raghavan, Paramita Das, Pablo Recinos et Varun Kshettry. « Peritumoral Edema and Surgical Outcome in Secretory Meningiomas : A Matched Cohort Analysis ». Dans 29th Annual Meeting North American Skull Base Society. Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0039-1679459.

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Papadas, Athanasios, Alexander Cicala, Alejandro Rizo, Chelsea Hope, Katerina Politi, Christian Capitini, Kristina Matkowskyj, Scott Abrams et Fotis Asimakopoulos. « 981 Peritumoral stromal remodeling licenses cDC1 through CD40 to elicit T-cell inflammation ». Dans SITC 37th Annual Meeting (SITC 2022) Abstracts. BMJ Publishing Group Ltd, 2022. http://dx.doi.org/10.1136/jitc-2022-sitc2022.0981.

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Williams, T., E. Roman-Perez, JL Rein, KD Amos et MA Troester. « P1-03-07 : Subtype-Specific Gene Expression Signatures in Peritumoral Non-Neoplastic Breast Tissue. » Dans Abstracts : Thirty-Fourth Annual CTRC‐AACR San Antonio Breast Cancer Symposium‐‐ Dec 6‐10, 2011 ; San Antonio, TX. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/0008-5472.sabcs11-p1-03-07.

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Rao, Manasa G., Travis R. Ladner, William H. Shuman, Rui Feng, Johanna T. Fifi, Reade A. D. Leacy, J. Mocco et Raj Shrivastava. « Safety and Efficacy of Preoperative Embolization of Meningioma in Patients with Preoperative Peritumoral Edema ». Dans Special Virtual Symposium of the North American Skull Base Society. Georg Thieme Verlag KG, 2021. http://dx.doi.org/10.1055/s-0041-1725490.

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Rathore, Saima, Hamed Akbari, Martin Rozycki, Michel Bilello, Robert A. Lustig, Christos A. Davatzikos, Jimit Doshi et Gaurav Shukla. « Technical note : a radiomic signature of infiltration in peritumoral edema predicts subsequent recurrence in glioblastoma ». Dans Image-Guided Procedures, Robotic Interventions, and Modeling, sous la direction de Robert J. Webster et Baowei Fei. SPIE, 2018. http://dx.doi.org/10.1117/12.2323331.

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Sebiskveradze, David, Cyril Gobinet, Nathalie CARDOT-LECCIA, Jean-Paul ORTONNE, Michel MANFAIT, Pierre JEANNESSON et Olivier PIOT. « Abstract 4052 : Highlighting intratumoral heterogeneity and peritumoral areas in human melanoma biopsies by infrared spectral microimaging ». Dans Proceedings : AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012 ; Chicago, IL. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/1538-7445.am2012-4052.

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