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1
Gantzer, Justine. « Integrative multi-omics characterization of mesenchymal tumors ». Electronic Thesis or Diss., Strasbourg, 2024. http://www.theses.fr/2024STRAJ056.
Texte intégralRésumé :
Ce travail de thèse s’articule autour de trois projets indépendants dont le but est de mieux caractériser trois tumeurs mésenchymateuses grâce à une approche multi-omique intégrative.Les tumeurs thoraciques indifférenciées SMARCA4-déficientes (SMARCA4-UT), initialement « sarcomes » semblaient répondre aux inhibiteurs de point de contrôle immunitaire (ICIs) comme d’autres tumeurs SWI/SNF déficientes, sans qu’aucune caractérisation de leur microenvironnement tumoral (TME) ne soit faite pour le comprendre. Grâce à des immunomarquages et à une analyse transcriptomique, nous avons mis en évidence un TME désertique avec une efficacité limitée des ICIs, en lien avec la cellule d’origine. Les tumeurs des cellules épithélioïdes périvasculaires (PEComes) forment un ensemble hétérogène de tumeurs coexprimant des marqueurs mélanocytaires et musculaires lisses pour lesquelles deux types génomiques se distinguent. Grâce à notre analyse, nous avons démontré qu’il existait d’autres réarrangements que ceux impliquant TFE3 et qu’il existait une classification transcriptomique pronostique de quatre sous types de PEComes, chacun étant enrichi d’un profil génomique et présentant des vulnérabilités différentes sur le plan thérapeutique. Les tumeurs desmoïdes (TDs) sont des tumeurs bénignes localement agressives dont l’hétérogénéité dans l’évolution tumorale est peu comprise. Grâce à notre analyse, nous avons mis en évidence que plus de 50% des TDs avaient des mutations dans un des gènes remodelant la chromatine et que parmi les deux sous-types transcriptomiques identifiés, le type immuno-myogénique doté d’un programme transcriptomique proche de celui des muscles, activait les voies de l’immunité évoquant un potentiel thérapeutique des ICIsThis thesis work takes the form of three independent projects aimed at better characterizing three mesenchymal tumors through an integrative multi-omics approach.The thoracic undifferentiated SMARCA4-deficient tumors (SMARCA4-UT), initially classified as "sarcomas," appeared to respond to immune checkpoint inhibitors (ICIs) similarly to other SWI/SNF-deficient tumors, despite no characterization of their tumor microenvironment (TME) being done to understand this response. Through immunostaining and transcriptomic analysis, we highlighted a desert-like TME with limited ICI efficacy, linked to the tumor’s cell of origin. Perivascular epithelioid cell tumors (PEComas) form a heterogeneous group of tumors co-expressing melanocytic and smooth muscle markers, with two distinct molecular types identified. Our analysis demonstrated that there are additional rearrangements beyond those involving TFE3 and provided a prognostic transcriptomic classification of four PEComa subtypes, each enriched with a unique genomic profile and presenting different therapeutic vulnerabilities. Desmoid tumors (TDs) are benign, locally aggressive tumors with poorly understood heterogeneity in tumor evolution. Our analyses revealed that more than 50% of TDs had mutations in chromatin remodeling genes and that among the two identified transcriptomic subtypes, the immuno-myogenic subtype, with a transcriptomic program similar to muscles, activated immune pathways suggesting a potential therapeutic benefit from ICIs
2
Liang, Ning. « Regulation of YAP by mTOR and autophagy reveals a therapeutic target of Tuberous Sclerosis Complex ». Thesis, Paris 5, 2014. http://www.theses.fr/2014PA05T055/document.
Texte intégralRésumé :
La sclérose tubéreuse complexe (TSC) est une maladie génétique caractérisée par une croissance des hamartomes dans différents organes y compris le cerveau, les reins, les poumons, la peau et le cœur. Ces lésions sont des sources de morbidité et de mortalité chez les patients TSC, car ils peuvent provoquerl’ épilepsie, l’autisme, le retard de développement et l’insuffisance rénale et pulmonaire. Les causes connues de TSC sont la perte de la fonction et les mutations des gènes TSC1 et TSC2. La majorité des lésions TSC contient plusieurs types cellulaires de la lignée mésenchymateuse, comme dans le cas des angiomyolipomes, l’lymphangioleiomyomatose et les angiofibromes. Un type unique de cellules épithélioïdes périvasculaires nommé (PEC) est constamment présent dans les lésions de TSC mésenchymateuses, comme angiomyolipomes et lymphangioleiomyomatose, basant sur les caractérisations morphologiques et l'expression des marqueurs communs mélanocytaires et myogéniques. Par conséquent, ces lésions sont officiellement classées, ainsi que d'autres tumeurs, comme PEComes. Leur origine cellulaire et les mécanismes moléculaires impliqués dans la pathologie restent à élucider. Ici, nous avons généré un modèle souris mosaïque TSC1 knockout qui développe des lésions rénales mésenchymateuses récapitulant périvasculaire épithélioïde cellules tumorales humaines (Pecoma) observés chez les patients TSC. Nous avons identifié YAP, le co-activateur transcriptionnel de la voie Hippo, a été régulée d'une manière mTOR-dépendante dans les lésions rénales de notre TSC1 knockout souris et les échantillons de l’angiomyolipome humaines. L'inhibition de YAP avec des outils génétiques ou pharmacologiques atténue considérablement la prolifération et la survie des cellules nulles TSC1 in vivo et in vitro. En outre, l’accumulation de YAP dans les cellules déficientes TSC1 / TSC2 pourra être dû à la dégradation de la protéine altéré par le système de l’autophagosome / lysosome. Ainsi, la régulation de YAP par mTOR et l'autophagie est un nouveau mécanisme de contrôle de la croissance, l'activité de YAP correspondant à la disponibilité des éléments nutritifs dans les conditions de croissance permissives. Il pourra servir comme une cible thérapeutique potentielle pour TSC et d'autres maladies avec une activité de mTOR déréguléeThe Tuberous Sclerosis Complex (TSC) is a genetic disease characterized by growth of hamartomas in different organs including brain, kidney, lung, skin, and heart. These lesions are sources of morbidity and mortality in patients with TSC, as they may cause intractable epilepsy, autism, developmental delay, renal and pulmonary failure. Known causes of TSC are loss of function mutations in TSC1 and TSC2 genes. The majority of TSC lesions contain multiple cell types of the mesenchymal lineage, as in the case of angiomyolipomas, lymphangioleiomyomatosis and angiofibromas. A unique cell type named perivascular epithelioid cell (PEC) is constantly present in mesenchymal TSC lesions, such as angiomyolipomas and lymphangioleiomyomatosis, basing on morphological features and the common expression of melanocytic and myogenic markers. Therefore, these lesions are officially classified, along with other tumors, as PEComas. Their cell of origin and the molecular mechanisms underlying their pathogenesis remain poorly defined. Here we generated a novel mosaic Tsc1 knockout mouse model which develop renal mesenchymal lesions recapitulating human Perivascular Epithelioid Cell tumor (PEComa) observed in TSC patients. We identified YAP, the transcriptional coactivator of Hippo pathway, was upregulated in both renal lesions of TSC mouse model and human angiomyolipoma samples in a mTOR-dependent manner. Inhibition of YAP with genetic or pharmacological tools greatly attenuates the proliferation and survival of Tsc1 null cells in vivo and in vitro. Futhermore, we found YAP accumulation in TSC1/TSC2 deficient cells is due to impaired degradation of the protein through the autophagosome/lysosome system. Thus the regulation of YAP by mTOR and autophagy is a novel mechanism of growth control, matching YAP activity with nutrient availability under growth permissive conditions. It may serve as a potential therapeutical target for TSC and other diseases with dysregulated mTOR activity
3
ELASRI, SAID. « Peche et pecheurs d'agadir ». Nantes, 1990. http://www.theses.fr/1990NANT3009.
Texte intégralRésumé :
Agadir est le premier port de peche marocain (181. 164 tonnes en 1985 pour une valeur de 136 280 750 dh). Ce sont les petits pelagiques, et notamment la sardine qui font la fortune de ce port. Aux activites de peche proprement dites, s'ajoute un important secteur de transformation (21 conserveries, 9 unites de congelation et 9 fabriques de sous-produits). Sur le plab social, la filiere halieutique offre l'emploi a 10 000 pecheurs, et fait vivre indirectement environ 60 000 personnes. Les obstacles auxquels se heurte l'industrie des peches a agadir peuvent etre ramenes a deux goulots d'etranglement ; l'expatriation de la flotte hauturiere et la mauvaise valorisation des debarquements realises par la flottille cotiereAgadir is the first moroccan fishing-port (181. 164 tons in 1985 worth 136 280 750 dh). Wealth in this harbour comes from the small pelagians, and among them the sardines. To the actual fishing activities, an important processing sector must be added (21 canneries, 9 freezing units and 9 factories of by-products). On a social point of view, the halieutic branch gives work to 10. 000 fishermen and so provides a living to about 60. 00 peoples. The obstacles met by the fishing industry en agadir can be summed up in two "bottlenecks" : the expatriation of the deep-sea fleet and the bad valorization of the unshipped cargo made by the inshore fishing fleet
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Nobles, Mia S. « Nobles-Pecora dissection manual of human anatomy ». Thesis, California State University, Long Beach, 2016. http://pqdtopen.proquest.com/#viewpdf?dispub=10134002.
Texte intégralRésumé :
This manual was written specifically as a guide for the beginner dissector to complete a prosected cadaver that will serve as an effective teaching and learning tool. The dissections are written in a manner that facilitates the preservation of more superfi- cial structures on the right side of the cadaver and deeper structures that otherwise would have been concealed on the left side of the cadaver. This format is ideal for students learning anatomy for the first time, as multiple planes can be compared on the same cadaver. The level of structures dissected and identified in these chapters was established with the understanding that the dissector’s knowledge of human anatomy is at the level of completion of a general undergraduate anatomy survey course.
5
Cap, Henri. « Comportement et systématique : le cas des Cervidae (Ruminantia, Pecora) ». Toulouse 3, 2006. http://www.theses.fr/2006TOU30189.
Texte intégralRésumé :
La position phylogénétique des Cervidae dans l'infra-ordre des Pecora a longtemps fait l'objet de nombreuses controverses, dont la plus récente est la confrontation des données morphologiques aux données moléculaires. Dans le but d'élargir le débat, notre étude propose d'étudier le répertoire comportemental de douze espèces de Pecora dont neuf Cervidae, afin de préciser leurs relations de parentés. Les résultats de nos observations éthologiques ont ainsi permis d'identifier des « éthotypes hypothétiques ancestraux », qui montrent que les Cervidae forment un groupe monophylétique constitué par deux lignées : la sous-famille des Cervinae ou plésiométacarpaliens qui apparaît comme un groupe naturel et les Cervidae télémétacarpaliens, Hydropotinae et Capreolinae. Ces derniers présentent deux groupes, avec un clade qui correspond aux Odocoileini et aux Rangiferi, et un groupe paraphylétique, constitué par les Hydropotini, les Capreolini et les Alceini. Une origine eurasiatique pour l'ensemble des Cervidae a été avancé, ainsi que la perte secondaire des bois chez Hydropotes. D'autre part, les Moschidae apparaissent comme le groupe frère des Cervidae, et les Bovidae semblent plus apparentés aux Cervoidea que ne le sont les Giraffidae. Une analyse impliquant d'avantage de taxons serait nécessaire, non seulement pour affiner nos résultats et notre méthode d'utilisation des données éthologiques, mais aussi pour discuter des perspectives théoriques qu'engendre l'apport du comportement en systématique phylogénétiqueThe phylogenetic position of Cervidae in the Pecoran infraorder caused many controversies, of which the most recent is the confrontation of the morphological data to the molecular data. With an aim to enlarge the debate, our research proposes to study the behavioral repertory of twelve species of Pecora including nine Cervidae, in order to specify their interrelationships. The results of our ethologic observations thus allowed to identify "ancestral hypothetical éthotypes", which show that Cervidae form a monophyletic group made up by two lineages : plesiometacarpals Cervids or Cervinae which appear as a natural group and telemetacarpals Cervids, Hydropotinae and Capreolinae. The last one presents two groups, with a clade which corresponds to Odocoileini and Rangiferi, and a paraphyletic group, consisted by Hydropotini, Capreolini and Alceini. A eurasiatic origin for Cervidae was advanced, as well as Hydropotes is secondarily antlerless. On the other hand, Moschidae appear as the sister group of Cervidae, and Bovidae seem more related in Cervoidea than are to it Giraffidae. An analysis implying more taxa would be necessary, not only to refine our results and our method of using ethological data, but also to discuss of the theorical prospects generated by the behaviour content in phylogenetic systematics
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KRIECK, HANS. « Le peche et la grace dans les oeuvres (scientifiques) d'eugen drewermann ». Université Marc Bloch (Strasbourg) (1971-2008), 1999. http://www.theses.fr/1999STR20023.
Texte intégralRésumé :
L'exegese corrige les nombreuses vues unilaterales de drewermann qui sont fondees dans sa biographie douloureuse: l'angoisse n'est pas la source du peche; la grace n'est pas efficace sans l'homme; le sacrifice de jesus est indispensable pour une theologie biblique; dieu s'occupe des siens.
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Moura, Pamella. « Vulnerabilidade de aquíferos : uso dos métodos DRASTIC e GOD na porção norte do complexo industrial e portuário do Pecém, Estado do Ceará ». reponame:Repositório Institucional da UFC, 2014. http://www.repositorio.ufc.br/handle/riufc/15023.
Texte intégralRésumé :
MOURA, P. Vulnerabilidade de aquíferos: uso dos métodos DRASTIC e GOD na porção norte do complexo industrial e portuário do Pecém, Estado do Ceará. 2014. 128 f. Dissertação (Mestrado em Geologia) - Centro de Ciências, Universidade Federal do Ceará, Fortaleza, 2014.Submitted by Daniel Eduardo Alencar da Silva (dealencar.silva@gmail.com) on 2015-01-15T17:02:09Z No. of bitstreams: 1 2014_dis_pmoura.pdf: 9527551 bytes, checksum: 1233d6d96206dfa5727fcbfc7fc595fa (MD5)
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This work was carried out in the northern portion of Industrial and Portuary Complex of Pecém, located in Fortaleza Metropolitan Region, Ceará State, Brazil, and aims to evaluate aquifer vulnerability through DRASTIC and GOD methods, and characterization of aquifer pollution hazard. In 2013, four steps of monitoring were made for 24 wells, from which it was possible to identify three main aquifer systems: Dunas, Barreiras and Fraturado. The monitored parameters were: pH, electrical conductivity, total dissolved solids, temperature, salinity, and water table. The pH results allowed classifying the groundwater as acids.Total dissolved solids concentrations are inside of the potability pattern and allowed classifying the groundwater as fresh water. The major acidity and salt concentrations were found during the dry season. The water table has average depth around 5 meters. The DRASTIC method showed indices between very low and very high, with predominance of high and very high vulnerability associated to the Dunas Aquifer, and moderate vulnerability associated to the Barreiras Aquifer. Areas with low and very low vulnerability occur in portions of the Barreiras Aquifer where the water table is most deep, and in the Fraturado Aquifer. Water table, recharge, and vadose zone were the parameters that most influenced these results. The GOD method showed indices between moderate and high, with high vulnerability associated to the Dunas Aquifer, and moderate vulnerability associated to the Barreiras and Fraturado aquifers. Water table was the parameter that most influenced the results of this method. In both methods, the vulnerability mapping showed contours very close to the ones of the geologic map, suggesting strong influence of the lithology in the evaluating process. Activities developed in the area were classified with subsurface contaminant load potential moderate and high. Aquifer pollution hazard obtained by GOD vulnerability and subsurface contaminant load potential indicates the dominance of areas with moderate pollution hazard. The results suggest that aquifer vulnerability and aquifer pollution hazard were underestimated during the construction of the industrial complex, regarding the area where each activity should be building. Comparing both methods, DRASTIC showed better results for studies that requires greater details, as EIAs and Master Plans. The GOD method showed better results for regional studies, as land zonings. The results also reaffirms the environmental fragility of great part of the area intended to the industrial complex, and reinforce the need for monitoring the industrial activities regarding pollution prevention.
Este trabalho foi realizado na porção norte do Complexo Industrial e Portuário do Pecém, localizado na Região Metropolitana de Fortaleza (CE), e teve por objetivo avaliar a vulnerabilidade dos aquíferos por meio dos métodos DRASTIC e GOD e caracterização do perigo de contaminação. Realizou-se quatro etapas de monitoramento em 24 poços ao longo de 2013, onde verificou-se a presença de três sistemas aquíferos: Dunas, Barreiras e Fissural. Os parâmetros monitorados foram: pH, temperatura, condutividade elétrica, sólidos totais dissolvidos, salinidade e nível estático. A medidas de pH permitiram classificar as águas subterrâneas como ácidas. As concentrações de Sólidos Totais Dissolvidos encontram-se dentro dos padrões de potabilidade e permitiram classificar as águas como “águas doces”. O método DRASTIC apresentou índices entre muito baixo a muito alto, com predomínio de vulnerabilidade alta a muito alta, associadas ao Aquífero Dunas, e vulnerabilidade moderada associada ao Aquífero Barreiras. As áreas de baixa e muito baixa vulnerabilidade ocorrem em porções do Barreiras com nível estático mais profundo e no Aquífero Fissural. O nível estático, a recarga e zona vadosa foram os parâmetros que mais influenciaram estes resultados. O método GOD apresentou índices entre moderado e alto, com alta vulnerabilidade associada ao Aquífero Dunas, e vulnerabilidade moderada associada aos Aquíferos Barreiras e Fissural. O nível estático foi o parâmetro que mais influenciou os resultados deste método. Nos dois métodos, o mapeamento da vulnerabilidade apresentou contornos muito próximos aos do mapeamento geológico, o que sugere forte influência da litologia no processo de avaliação. As atividades presentes na área foram classificadas com potencial de carga contaminante entre moderado e elevado. O perigo de contaminação obtido pelo método GOD e pelo potencial de carga contaminante indicou o predomínio de áreas de perigo moderado. Os resultados sugerem que a vulnerabilidade dos aquíferos e o perigo de contaminação foram subestimados na instalação do complexo, no que concerne à área onde cada atividade industrial poderia ser instalada. Na comparação entre os métodos, o método DRASTIC apresentou melhores resultados para estudos que requeiram maior detalhamento, como EIA/Rimas e Planos Diretores. O método GOD apresentou resultados mais satisfatórios para estudos regionais, como zoneamentos territoriais. Os resultados também reiteram a fragilidade ambiental de grande parte da área destinada à instalação do complexo industrial, e reforçam a necessidade de monitoramento das atividades industriais no que diz respeito a prevenção de contaminações.
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Stříž, Michal. « Konstrukční návrh pece ». Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2012. http://www.nusl.cz/ntk/nusl-230111.
Texte intégralRésumé :
This master´s thesis deals with issues of tube furnaces in the process industries, especially with a design of a transfer pipeline, which is one of the main parts of the furnace. According to the requirements, designed pipeline is stress analyzed using the two pipeline programs Japar and Caesar II, that are briefly described. In addition to this design several variants of analysis are performed and the results are compared. Comparison helps to explain the diversity of the programs. For example, the effect of elbows on the stress analysis. The master´s thesis also describes the factors that affect the working life of the furnace.
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PANE, LUBIS ERNANI. « L'organisation et l'amenagement des ports de peche indonesiens - comparaison avec l'organisation et l'amenagement des ports de peche francais et europeens ». Nantes, 1989. http://www.theses.fr/1989NANT3001.
Texte intégralRésumé :
La comparaison de l'amenagement et l'organisation entre des ports de peche indonisiens, francais, belges et allemands met a jour trois modes de gestion differents, soit d'etat, semi-public ou municipal. L'etude de ces trois modes de gestion illustre les differences qui existent dans le domaine socio-culturel, economique, technique ou politique entre un pays developpe et un pays en voie de developpement. La prise en compte de la surface des eaux indonesiennes nous permet de constater que la potentialites sont importantes et que l'amenagement des ports de peche indonesiens doit etre developpe alors qu'aujourd'hui 87,5% des ports sont de type cotier. La presence de ports industriels de type oceanique comme le port de jakarta est indispensable dans un contexte de developpement d'un veritable arriere-pays a l'image de ceux rencontres autour des ports europeens. Ce developpement est favorise par la concentration d'usines de transformation et d'industries annexes. Il ne pourra se faire sans l'organisation des pecheurs et des armateurs, des mareyeurs-conserveurs et des petits commercants, ou bien encore l'amelioration des voies et des moyens de transport. .The comparative study of arrangement and organization of the fishing ports in indonesia, france, belgium and german shows the existence of three different modes of management : management by state; management by state and private; and management by municipality. Intensive study of these modes of management bring forward the differences that exist in social and cultural lives, economy, technology and politic between the developed and the developing countries. Taking account of the vastness of indonesian water surface, we see that indonesia has a fremendous potentialities and that the arrangement of the fishing ports have to improve in the near future; as right now 87,5% of the indonesian ports is the type of coastal ports. The presence of industrial fishing port of oceanic type like that of jakarta is essential in the contex of the favorable development of fishing industry. The existence of the big port can stimulate the distribution network and the development of real hinterland activities in the same manner like that encountered in the european ports. This development is propelled by the concentration of the fish processing facilities and its related industries. .
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Pelaprat, Corinne. « Le cantonnement de peche, un veritable outil de gestion ? exemple du cantonnement de peche de calvi (corse, mdeiterranee nord-occidentale) ». Corte, 2000. http://www.theses.fr/2000CORT3060.
Texte intégralRésumé :
Le monde de la peche est en crise, surtout depuis les annees 90. Pour remedier a ce probleme, differents systemes de gestion ont ete instaures a l'echelle mondiale, soit des mesures visant a diminuer l'effort de peche, soit la creation d'espaces proteges permettant la reconstitution des stocks. Confrontee a une baisse importante des rendements de la peche langoustiere, la corse a ete une des pionnieres en ma matiere en instaurant a la fin des annees 70 la mise en place de 9 cantonnements de peche sur le pourtour insulaire. La creation de ces cantonnements repose sur des mesures prises en etroite collaboration avec les differents pecheurs. Ils se differencient des autres systemes de protection generalement utilises par l'absence de surveillance, leur existence reposant essentiellement sur le respect de chacun. L'etude entreprise ici vise, par le suivi regulier du cantonnement de peche de calvi (de mai 1994 a decembre 1999), a etudier l'influence d'un tel outil de gestion sur un ensemble d'especes cibles. La premiere partie de cette etude a consiste a mettre en evidence, par la technique du comptage visuel sur transects fixes, l'existence d'un effet reserve. Dans les grandes lignes ce dernier c'est revele semblable a celui observe dans les autres systemes de protection plus generalement utilises (parcs nationaux, regionaux, reserves naturelles). Nos resultats ont mis en evidence pour la majorite des especes cibles des changements : ' de structure demographique, avec des proportions de grands individus plus elevees dans la reserve qu'au niveau des zones de peche, ' de densite et de biomasse, avec des valeurs egalement plus elevees au sein du cantonnement de peche, ' de repartition spatiale des individus, avec une remontee vers les faibles profondeurs au sein du cantonnement de peche. La seconde partie de ce travail avait un double but. ' dans un premier temps ; evaluer l'influence des mesures de protection sur les variations saisonnieres naturelles des parametres etudies en premiere partie. Notre etude a permis de mettre en evidence pour les especes cibles une accentuation des variations saisonnieres au sein du cantonnement de peche, avec des regroupements de reproducteurs plus importants durant les periodes de reproduction et un nombre de petits individus plus eleve durant les periodes faisant suite aux phases de recrutement. Ces remarques suggerent qu'en comparaison a un certain nombre de reserve marine, l'effet cascade au sein du cantonnement de peche de calvi est attenue. ' dans un deuxieme temps ; observer sur six annees d'etude l'evolution temporelle de l'effet reserve. A l'exception de la richesse specifique, qui a tendance a diminuer plus rapidement au niveau des zones de peche que dans le cantonnement, l'ensemble des parametres etudies reste relativement constant dans la reserve comme au sin des zones de peche. Une stabilite qui reposerait sur une acceleration de la migration vers les zones de peche des predateurs cotiers (grands individus des especes cibles), rapidement devenus trop nombreux dans un espace protege restreint. Malheureusement ces explications sont encore sous forme d'hypotheses qu'il conviendrait de verifier.
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FOSSAT, BERNARD. « La gestion du pecule a l'hopital psychiatrique public : approches et perspectives ». Aix-Marseille 2, 1989. http://www.theses.fr/1989AIX20146.
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Seidman, Michael Aaron. « An inconvenient truth : leukocyte transendothelial migration without pecam / ». Access full-text from WCMC:, 2008. http://proquest.umi.com/pqdweb?did=1428864521&sid=12&Fmt=2&clientId=8424&RQT=309&VName=PQD.
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Heayn, Michelle Diane. « The Role of Caveolae in PECAM-1 Mechanotransduction ». Diss., Temple University Libraries, 2014. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/263778.
Texte intégralRésumé :
PhysiologyPh.D.
Altered fluid flow, which is found in branches and curvatures of arteries, results in abnormal forces on the endothelial cells (EC). These forces have been shown to alter EC gene expression and phenotype and to activate several cellular structures including G-proteins, ion channels, adhesion molecules, and caveolae. Recently, PECAM-1 has been implicated as the primary sensor of hemodynamic forces in EC. Shear stress rapidly induces tyrosine phosphorylation of PECAM-1 and the recruitment of SHP-2. These events appear to contribute to shear-activation of ERK1/2. Additionally, PECAM-1 has been shown to form a mechanosensory signaling complex with VE-cadherin, VEGFR2, and βcatenin which plays a role in adhesion molecule expression and regulation of NF-κB. Past work has shown that caveolae membrane domains also serve as mechanotransduction sites that regulate many of these same second messengers. Based on these novel observations, we hypothesize that the PECAM-1 mediated mechanotransduction requires caveolar membrane domains to effectively propagate mechano-signals. In this study, we intended to specifically test this hypothesis by 1) evaluating the role of caveolae in shear stress-induced PECAM-1 tyrosine phosphorylation, recruitment of SHP-2, and formation of a signaling complex with VE-cadherin, VEGFR2, and βcatenin and 2) determining the functional significance of PECAM-1 compartmentalization within caveolae with regard to changes in endothelial cell phenotype induced by atherogenic patterns of flow. Here, we have identified a pool of PECAM-1 which localizes within lipid rafts and caveolar membranes. This pool of PECAM-1 was shown to be activated by tyrosine phosphorylation and recruitment of mechanosignaling complex members in response to shear stress. We were also able to demonstrate complex formation in an in vivo model of disturbed blood flow. The significance of PECAM-1 compartmentalization to these membrane microdomains was demonstrated in endothelial cells treated with raft/caveolae disrupting compounds where shear stress-induced PECAM-1 tyrosine phosphorylation was markedly attenuated. Finally, we attempted to generate an adenovirus expressing a mutant form of PECAM-1 which was unable to target to lipid rafts in order to determine the importance of PECAM-1 localization in lipid rafts and caveolae on its downstream signaling in response to shear stress. Results from these studies provide new knowledge as to how endothelial cells respond to changing hemodynamic parameters, which could provide greater insight into how flow influences vascular homeostasis.
Temple University--Theses
14
Harrison, James Burr. « Rock art boundaries : considering geographically limited elements within the Pecos River Style ». Thesis, Texas A&M University, 2004. http://hdl.handle.net/1969.1/501.
Texte intégralRésumé :
This thesis examines six prominent Pecos River Style rock art anthropomorph attributes to determine if they are found in limited geographic districts of the Lower Pecos Region. Both Boyd (2003) and Turpin (2004) have suggested that spatially-segregated motif distributions exist in the rock art and that these patterns are important in understanding regional prehistoric hunter-gatherer lifeways during the Archaic Period. This study verifies that the feather hip cluster motif is geographically limited, identified only in the neighboring Seminole and Painted Canyon systems. As part of this spatial analysis, the previously undocumented principle of intersite stylistic traditions is introduced. Possible explanations for these anthropomorph attributes are also discussed. Finally, structural analyses of the six attributes are presented.
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MINGUY, JEAN-LUC. « Concevoir pour aider a l'action situee. Le travail en passerelle de navires de peche : role de la carte de peche comme representation ». Paris, CNAM, 1995. http://www.theses.fr/1995CNAM0234.
Texte intégralRésumé :
Ce travail de recherche s'inscrit dans la problematique theorique des situations d'activite instrumentee. Le cadre theorique dont on s'inspire propose une approche cognitive des objets et des systemes techniques susceptible de rendre compte et d'interpreter les interactions entre le sujet, les instruments et l'objet du travail. Dans ce travail, l'enrichissement de ce cadre theorique tient compte d'une part de l'emergence de representations pour l'action, d'autre part de la creation d'instruments specifiques par le sujet pour repondre a certaines caracteristiques de l'objet du travail. A bor de navires de peche le travail de capture requiert l'usage de systemes techniques concus pour informer le patron pecheur de certaines aspects du processus de peche et de navigation. On accorde une importance singuliere a certaines specificites du domaine maritime, particulierement celui de la peche au large : conditions d'exploration de l'environnement, conditions d'organisation du travail. L'objet de recherche propose est la carte de peche en tant que representation. C'est un objet qui est a la fois un support a l7expertise concretisee, un outil que les patrons peuvent se transmettre, et la materialisation d'un modele mental de la situation de travail. Les analyses proposees sont centrees sur les operations effectuees sur la carte de peche. Nous proposons la notion de systemes d'instruments pour rendre compte des resultats des analyses d'une carte de peche particuliere, mais egalement pour developper un point de vue sur la dynamique de conception des artefacts. Le modele descriptif que nous presentons est susceptible d'orienter les principes de conception des systemes d'instrumentation. Des recommandations pour la conception sont elaborees et discutees du point de vue des besoins reels des utilisateurs et de l'etat actuel de developpement de certains systemes d'instrumentation de passerelleThis research is based ont he theoretical frame which is nammed "situations d'activite instrumentee". This frame gives us a cognitive approach for objects and technical systems which is able to interpret and account for interaction between the subject, the tools and the working object. Here the enrichment of this theoretical frame takes two major ergonomica l aspects into account : the existence of mental representaions for actions and the design of specific tools made by the user himself in order to comply with the characteristics of the working object. On board fishing vessels catching fish requiers the use of technical systemes designed to inform the skipper on some aspects of the fishing process and navigation. Attention is paid to particular characteristics of the maritime domain, and especially deep-sea fishing : condiitons for the exploration of the environment, and for the organization of the work. Our object of research is the deep-sea charts as a representation. These charts provide an accurate representation of the skipper's expertise. They ar e also tools that skippers are able to transmit themselves. And finally they are mental models of the working situations which is recorded in black and white. We focused analysis on the operations which are carried out on one of the charts by one skipper. We proposed the concept of "tool systems" to account for the results of a specific deep-sea chart analysis. Such a concept allows us to devlop a point of view on the artefacts design process. The descriptive model that we have elaborated could give relevant indications for "tool systems" design process. Recommandations for the design process are elaborated and discussed from the point of vie w of the users'real needs and the current state of development of certain bridge "tool systems"
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Queiroz, Moacir de Araujo. « DeterminaÃÃo do Ãndice de sensibilidade do litoral PecÃm - Mundaà ». Universidade Federal do CearÃ, 2003. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=3259.
Texte intégralRésumé :
Apesar do constante progresso da tecnologia de seguranÃa operacional na exploraÃÃo e no transporte de petrÃleo, temos presenciado, a cada dia, um grande nÃmero de acidentes e de magnitudes diversas, que variam desde pequenos derrames operacionais, como o ocorrido em 04/08/2000 em uma das plataformas de Paracuru onde vazaram 100 litros de Ãleo cru, atà acidentes graves como o vazamento dos 4 milhÃes de litros de Ãleo no Rio IguaÃu-Pr, 2000, ou mesmo o desastre da P-36 em 2002 e do Exxon Valdez, 1989. A proporÃÃo do derramamento de petrÃleo depende parcialmente na direÃÃo que à carregado pelos ventos e das correntes oceÃnicas. Se o derramamento chega ao litoral as conseqÃÃncias na Ãrea costeira geralmente à desastrosa. Um derramamento de petrÃleo pode causar problemas sÃrios nos locais onde ocorre e persistir por dÃcadas, mas de uma maneira geral o ambiente marinho nÃo tem sofrido prejuÃzos irreversÃveis. Estudos realizados sobre derramamento de petrÃleo em regiÃes temperadas e tropicais mostraram que em clima tropical a recuperaÃÃo à mais rÃpida, pois em clima temperados os hidrocarbonetos sÃo mais estÃveis e persistem por mais tempo nas Ãguas frias. Dependendo do volume derramado, das caracterÃsticas do produto e das condiÃÃes oceanogrÃficas no momento do acidente, o Ãleo ou outro subproduto pode alcanÃar a costa e afetar severamente o meio ambiente. Nestes casos, à necessÃrio conhecer detalhadamente tanto os ecossistemas costeiros como suas caracterÃsticas geoambientais, para auxiliar a tomada de decisÃes sobre prioridades de proteÃÃo e minimizar os impactos destes derrames, jà que poderà ocorrer interferÃncia sobre a Qualidade da Ãgua; sobre a Biota Marinha, sobre as Atividades econÃmicas (especialmente as atividades relacionadas ao transporte marÃtimo e atividades de pesca), bem como o turismo da regiÃo afetada.A Ãrea de trabalho enfocada neste estudo foi definida levando em consideraÃÃo os riscos induzidos que geram o Complexo PortuÃrio do PecÃm, o Pier de Paracuru, alÃm dos campos de produÃÃo de petrÃleo de Atum, Espada, Xareu e Curimà e as rotas de navios de transporte de Ãleo, que podem atingir, em caso de derramamento, o litoral de SÃo GonÃalo do Amarante, Paracuru, Paraipaba, Trairi e parte do litoral de Itapipoca.Despite the constant progress of technology, operational safety in the exploitation and transportation of oil, we have witnessed, each day, a large number of accidents and various magnitudes, ranging from small operational spills such as occurred on 04/08/2000 in one of the platforms where Paracuru leaked 100 gallons of crude oil, to serious accidents such as leakage of the 4 million liters of oil into the Rio IguaÃu-Pr, 2000, or even the disaster of the P-36 in 2002 and the Exxon Valdez, 1989. The proportion of the oil spill depends partly on the direction that is loaded by winds and ocean currents. If the spill reaches the coast the consequences in coastal area is generally disastrous. An oil spill can cause serious problems in places where occur and persist for decades, but in general the marine environment has not suffered irreversible damage. Studies on oil spills in tropical and temperate regions that have tropical climate in the recovery is faster, because in temperate climate oils are more stable and persist longer in cold water. Depending on the volume spilled, of product characteristics and oceanographic conditions at the time of the accident, the oil or other product may reach the coast and severely affect the environment. In these cases it is necessary to know as much detail as coastal ecosystems geoambientais features, to help making decisions about priorities for protection and minimize the impacts of these spills, as interference may occur on the Quality of Water, on the Marine Biota on economic activities (especially activities related to shipping and fishing activities) and the tourism region of the desktop afetada.A focused in this study was defined taking into account the risks that generate the induced Port Complex PecÃm of the Pier of Paracuru, beyond the fields of oil production from Tuna, Sword, Xareu and Curimà and the routes of vessels transporting oil, which can reach in case of spill, the coast of SÃo GonÃalo do Amarante, Paracuru, Paraipaba, Trairi and part of the coast of Itapipoca.
17
Koffie-Bikpo, Céline Yolande. « La peche artisanale maritime en cote d'ivoire : etude geographique ». Nantes, 1997. http://www.theses.fr/1997NANT3015.
Texte intégralRésumé :
Sur le plan theorique, le sujet a ete principalement traite selon une approche systemique qui permet une vision globale de l'activite en mettant l'accent sur l'etude des interactions. Une etude bibliographique fouillee, ainsi que l'analyse des donnees statistiques et les enquetes de terrain ont permis d'apporter des reponses complementaires a la bonne analyse du theme. La peche artisanale maritime est une activite qui s'etend spatialement sur tout le littoral ivoirien. Elle se materialise par une multitude d'echouages de differentes tailles et par deux ports. Le lieu de travail, la mer, et leslieux de vie s'echelonnent les uns a la suite des autres. Les pecheurs sont pour la plupart ghaneens, ce qui imprime une physionomie sociale particuliere a leur communaute. Les zones de peche appartiennent a priori a tout le monde ; mais les populations riveraines des littoraux exercent un certain controle sur la mer et sur l'activite par l'octroi des espaces de vie qui sont regis selon le droit coutumier. La peche s'exerce uniquement sur le plateau continental. On observe une production relativement faible qui correspond a 30% de la production nationale. 90% de cette production est le fait des filets. Ces chiffres doivent etre pris avec prudence, car les donnees statistiques sont de mauvaise qualite. Malgre tout, une intense activite se deroule en aval de la filiere et est le fait des femmes. Les circuits de distribution s'etendent d'abord autour des campements de peche ensuite vers la localite la plus proche et enfin vers abidjan. La peche artisanale maritime ivoirienne est dynamique. Neanmoins son exercie cree un certain nombre de problemes lies aux faibles revenus des pecheurs, contrairement a ceux des commercants ; au faible niveau de developpement du secteur, a sa production relativement basse et a des circuits de commercialisation qui n'explorent pas le marche au dela d'une certaine limite. Ces differents problemes trouvent leur explication dans des conditions naturellesdefavorables et une politique de developpement qui tend a ne se preoccuper que de la partie amont de la filiere. Pour autant, le caractere socio-culturel particulier des pecheurs est rarement pris en compte pour apporter une solution aux problemes poses. Des propositions sont presentees pour assurer une meilleure gestion de l'ensemble de l'activiteAt the theoretical level, the topic was treated on the basis of a systemic approach which provides an overall view of the acitivity by highlighting the study of interactions. A thorough bibliographie review, an analysis of statistical data and a field survey provided further answers needed for the analytical work. Artisnal sea fishing is carried out on the entire ivorian coastline. It involves numerous groundings of varying sizes and two harbours. The place of work, the sea and living places are determined in relation to one another. The fishermen are mainly ghanaians and this gives a particular social character to their community. The fishing zones in principle, belong to everyone; but the riverine coastal populations exercice some control over the sea and the activity by granting living quarters that are governed by customary rights. Fishing is mainly conducted on the continental shelf. Production is relatively low representing about 30% of the national production. 90% of the production is by nets. These figures are only tentative as the statistical data is highly unreliable. Be that as it may, there is an intensive activity among the women down stream. Distribution channels primarily centre around fishing settlements spreading out to the nearest towns and eventually abidjan. The ivorian artisanal sea fishing is dynamic. However, it entails a number of problems related to the low incomes of the fishermen, unlike trading, to the weak level of development of the sector, its relatively low production level and the marketing channels which do not explore the market beyond a certain unit. These various problems stem from unfavorable natural conditions and a development policy which tends to focus on the upstream end of the sub-sector. Furthermore, the peculiar socio-cultural context of the fishermen is rarely taken into account in seeking, solutions to the problems encountered. Proposals are made for an enhanced management of the entire activity
18
VEERAVALLI, ROGER. « Etude et developpement d'un sonar multifaisceaux pour la peche ». Paris 6, 1998. http://www.theses.fr/1998PA066695.
Texte intégralRésumé :
Nous presentons ici les resultats d'une etude menee en collaboration avec l'ifremer et portant sur le developpement d'un prototype de sonar multifaisceaux destine a des applications de peche. L'objectif recherche est de fournir en temps reel, une image du plan transversal a la direction d'avancement du bateau. Le mode de representation choisi est une image sectorielle de 32 degres avec une resolution angulaire de 2 degres. La portee maximale recherchee est d'environ 1000 metres. La technique de compression d'impulsion est utilisee pour assurer a la fois grandes portees, un meilleur rapport signal sur bruit et une bonne resolution temporelle. Une compensation dynamique des mouvements de roulis du bateau est assuree. Nous decrivons tout d'abord les differents systemes acoustiques actuellement utilises sur les navires de peche. Les motivations du developpement d'un sonar multifaisceaux de peche sont explicitees. Nous presentons ensuite les caracteristiques propres a l'antenne du sonar. Celle-ci est constituee d'un reseau lineaire de 32 transducteurs, utilise successivement en emission et en reception. La technologie mise en uvre pour elaborer les transducteurs repose sur l'emploi de ceramiques composites utilisees a des frequences voisines de 100 khz. Une modelisation numerique du rayonnement de l'antenne a ete realisee pour permettre d'assurer la formation des voies d'emission et de reception. Les resultats de cette etude ainsi que la validation experimentale sont presentes. Nous decrivons ensuite l'electronique de commande du sonar, quasi entierement numerique. A l'exception de la preamplification des signaux recus (tvg) et leur detection synchrone, la formation de voies et l'ensemble du traitement de signal sont traites a l'aide d'une electronique numerique dediee. Enfin, on expose les resultats de la campagne d'essais en mer. Les images presentees illustrent les bonnes performances du prototype en terme de detection de bancs de poissons.
19
Nam, Samba. « Societe et economie de la peche maritime au senegal ». Toulouse 2, 1988. http://www.theses.fr/1988TOU20070.
Texte intégralRésumé :
L'economie senegalaise est essoufflee par la fragilite de sa couverture alimentaire et la concurrence subie par l'arachide et les phosphates sur le marche international. Cependant, le pays dispose d'une cote poissonneuse, et, d'un secteur peche porteur. Cette activite qui intervient dans l'alimentation, est aussi creatrice d'emplois et, pourvoyeuse de devises. On distingue deux types de peche. La peche artisanale est animee par les communautes de pcheurs de culture et de tradition marine installees tout au long du littoral. Elle a pour objectif la satisfaction des besoins interieurs. La peche industrielle avec comme port d'attache dakar doit aider a reequilibrer la balance commerciale. La peche interesse a la fois les pecheurs, l'etat, la societe et l'economie senegalaisesSenegalese economy is stiffled by the fimsiness of its food cover and the competitive action on pea nut and phosphate on the international market-however the senegalese coast is abounding in fish and its fishing activity is a strong one. This activity which supplies the country with food also creates employment and secures foreign currency. Two different types of fishing can be found : - artisanal fishing is organised by fishermen communities of sea culture and tradition who are settled along the coast. Its purpose is to answer domestic needs. - industrial fishing - based in dakar - must lead to setting the balance of trade. - fishermen, government, senegalese society and economy are all highly concerned by fishing
20
Queiroz, Moacir de Araujo. « Determinação do índice de sensibilidade do litoral Pecém - Mundaú ». reponame:Repositório Institucional da UFC, 2003. http://www.repositorio.ufc.br/handle/riufc/27337.
Texte intégralRésumé :
QUEIROZ, M. de A. Determinação do índice de sensibilidade do litoral Pecém - Mundaú. 2003. 225 f. Dissertação (Mestrado em Ciências Marinhas Tropicais) - Instituto de Ciências do Mar, Universidade Federal do Ceará, Fortaleza, 2003.Submitted by Geovane Uchoa (geovane@ufc.br) on 2017-11-08T12:20:31Z No. of bitstreams: 1 2003_dis_mdeaqueiroz.pdf: 6968438 bytes, checksum: 8161b9596514f07d34084eb2c94e1a42 (MD5)
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This work is part of the Master Science Program in Marine Tropical Sciences at the Institute of Marine Sciences – LABOMAR / Federal University of Ceará, concerning the research theme on Environmental Impacts and Biology of Conservation and has as main goal, the elaboration of an environmental sensibility map at 1: 10.000 scale, using an methodology based by the National Oceanic and Atmospheric Administration - NOAA, which is broadly used for producing environmental sensibility maps for coastal areas and oil spreads. The work area was defined in this study by taking in consideration the induced risks originated from the Complex of Pecém Harbour, the Pier of Paracuru besides the oil camps of Atum, Espada, Xareu and Curimã and ship oil routes that may hazard the coasts of São Gonçalo do Amarante, Paracuru, Paraipaba and part of Trairi municipalities in case of an oil spill. The dissertation focused on the sensibility of coastal ecosystems by means of a coastal sensibility index (ISL). This index hierarchies several types of coastal outlines under an 1 to10 scale being the highest degree, the most sensible. The ISL is based on the geomorphological features of the coastal, the basement for determinations of the degree of impact and the residence of the spilled oil, as well as, in many cases, pointing to types of possible cleaning and relief procedures. Geomorphology is also determinant for the type and density of the biological communities present at the area. The scope of this work contains information directed to far beyond the protection of human life, but to reduce environmental hazards due to oil waste and to make efficient the efforts of isolation and cleaning / remove. This instrument may also be used as technical support to other social – economic activities and environmental management.
Este trabalho de pesquisa é parte integrante do curso de mestrado em Ciências Marinhas Tropicais da Universidade Federal do Ceará / Instituto de Ciências do Mar – LABOMAR, na linha de pesquisa Impacto Ambiental e Biologia da Conservação e tem como objetivo principal a elaboração de um mapa de sensibilidade ambiental, na escala de 1:10.000, utilizando uma metodologia baseada na NOAA – National Oceanic and Atmospheric Administration, sendo internacionalmente utilizada na elaboração de mapas de sensibilidade ambiental costeira a derrames de óleo. A Área de trabalho enfocada neste estudo foi definida levando em consideração os riscos induzidos que geram o Complexo Portuário do Pecém, o Pier de Paracuru, além dos campos de produção de petróleo de Atum, Espada, Xareu e Curimã e as rotas de navios de transporte de óleo, que podem atigir, em caso de derramamento, o litoral de São Gonçalo do Amarante, Paracuru, Paraipaba, Trairi e parte do litoral de Itapipoca. Foi enfocado neste trabalho de pesquisa a sensibilidade dos ecossistemas costeiros utilizando um índice de sensibilidade do litoral (ISL). Este índice hierarquiza os diversos tipos de contorno da costa em uma escala de 1 a 10, sendo o índice tanto maior quanto maior o grau de sensibilidade. O ISL é baseado nas características geomorfológicas da costa, fundamentais para a determinação do grau de impacto e permanência do óleo derramado, assim como, em muitos casos, para os tipos de procedimento de limpeza passíveis de serem empregados. A geomorfologia é, também, determinante para o tipo e a densidade das comunidades biológicas presentes na área. O escopro deste trabalho contem informações que objetivam, além da proteção da vida humana, reduzir as conseqüências ambientais do vazamento e tornar eficientes os esforços de contenção e limpeza / remoção. Por outro lado, é, também, possível a utilização desse instrumento como suporte técnico a outras atividades socio-econômicas e de gestão ambiental.
21
Rafaj, Svatomír. « Rotační sušící a sintrovací pece ». Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2018. http://www.nusl.cz/ntk/nusl-377759.
Texte intégralRésumé :
This thesis deals with rotary drying and sintering kilns. The first part focused upon construction of the kilns, kiln processes and the options of technological arrangement of the kilns. The thesis second part presents two experiments. The first one is targeted to find the relation between residence time, kiln rotary speed and kiln slope in longitudinal direction. The examinations analysed individually the relation between kiln rotary speed and residence time and the relation between kiln slope and residence time. Finally, the regression equation describing the relation between holding time, kiln rotary speed and kiln rake was established. The results given by regression equation much closer to the real one then the results given by literature. The difference between real residence time and the regression one is about one minute. The second one is concerned with producing a set of equations with respect of mass and heat balance in case of drying process. The input material was wet crushed tetra packs. There were established technological conditions of the material, necessary burner energy input, heat losses and distribution of heat between material and flue gas. There were taken away almost 80 percent of heat energy by flue gases. The remaining 20 percent was divided between latent heat, material and heat losses through the shell of the rotary kiln.
22
Brada, Karel. « Bajonetový uzávěr dveří přetlakové pece ». Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2011. http://www.nusl.cz/ntk/nusl-229402.
Texte intégralRésumé :
In this master's thesis a design of door for helium quenching furnace is described. Based on background research, several options for the design have been compared. All calculations were carried out based on structural needs resulting from high pressure gas quenching technology. By the ending of this thesis a mounting procedure and rough cost price estimation is described. Part of master's thesis is also a virtual 3D prototype and a drawing documentation.
23
Sénáši, Martin. « Tepelný výpočet ohřevné trubkové pece ». Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2016. http://www.nusl.cz/ntk/nusl-241884.
Texte intégralRésumé :
The main aim of the thesis is to evaluete properties of a simplified thermal calculation of the direct fired heater published in the journal Applied Energy at 2010 and its application to specific industrial cases. At first, general issues of process heaters are talk over. Second, calculation model in cited article is briefly introduced. After that, custom computational model at program Maple is created in accordance with published article. Subsequently, the model is applied to the existing process furnaces in the form of a check calculation. An integral part of the work is also a detailed discussion of the results obtained.
24
Lamparter, Mathias. « Foxc1 regulates Pecam-1 Expression in embryonic Endothelial Progenitor Cells ». Diss., lmu, 2008. http://nbn-resolving.de/urn:nbn:de:bvb:19-89435.
Texte intégral
25
Dhanjal, Tarvinder Singh. « The role of PECAM-l in platelet function and formation ». Thesis, University of Birmingham, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.487509.
Texte intégralRésumé :
PECAM-I is a 130kDa member ofthe immunoglobulin superfamily, expressed on the surface ofhaematopoietic cells. The cytoplasmic tail contains two immullOreceptor tyrosine based inhibition motifs which can mediate both stimulatory and inhibitory signals. The aim of this thesis is to investigate the function of PECAM-I in the regulation of platelet activation and fonnation. Using PECAM-Io/' mice and cross-linking of PECAM-I using specific antibodies, I demonstrate a minor inhibitory role on platelet responses to the collagen receptor GPVI, the integrin allb~3 and the C-type lectin receptor CLEC-2. Furthennore, the degree of inhibition is considerably less than that produced by P0I2Ã?Â? This weak inhibitory effect ofPECAM-1 on platelet activation indicates that PECAM-I is not a major regulator of platelet activation. Further research reveals an important role in thrombopoiesis. Following induced thrombocytopenia, recovery . . of the peripheral platelet count is impaired in PECAM-l'' mice. A migration defect in PECAM-l'' megakaryocytesis identified in response to a gradient of SDFla. These observations are confinned in vivo with the demonstration of altered spatial localisation of megakaryocytes within the bone marrow in PECAM-Io/- mice. A further chapter considers the various approaches that could be used to establish the molecular basis ofthis effect.
26
Dangerfield, John Paul. « Mechanisms of PECAM-1-Mediated Leukocyte transmigration in murine models ». Thesis, Imperial College London, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.498107.
Texte intégral
27
Martins, Vera LÃcia Freire. « Competitiveness shown between the ports of Fortaleza and the PecÃm ». Universidade Federal do CearÃ, 2009. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=5016.
Texte intégralRésumé :
nÃo hÃThe Plan of Government of Cearà (1987-1990) highlighted how economic hub for Cearà industrial expansion with the installation of new plants with high production scale. Failed to explain clearly, but the deployment of a new port, but to expand the port of Fortaleza to consolidate its integration with Industrial District PajuÃara. With the state policy of strengthening the local economy, but with bias to the external market, the need arose to build a new port complex. Thus, in 1995, appeared the idea of building another port located away from urban centers, with infrastructure capable of providing an industrial metal and petrochemicals, especially with a modern port terminal in a position to offer efficient operations at competitive rates and access roads Free. Opened in 2002, the Industrial and Port Complex PecÃm was modeled to meet the demand for general cargo and containers and be included in the international sea route large ships. Indeed, the creation of the Industrial and Port Complex PecÃm impacted the trade flow from Cearà and modified the movement of goods from the port of Fortaleza. Thus, this study aims to determine the level of competitiveness of the port of Fortaleza in confrontation with the port of PecÃm. Search is thus to examine the hypothesis of complementarity of the activities of the two ports. The methodology consists of the interpretation of descriptive statistics about trade flows and, in analytical terms, the use of indicators of revealed competitive advantage in the tradition of Balassa (1965). The results show that relevant portion of the main products imported and exported through the port of Fortaleza was absorbed by the Port of PecÃm, but that over the study period, there was a significant recovery drive from the port of Fortaleza. Moreover, it appeared certain specialization in relation to economic blocs, whether in respect of export or import. Showed that the initial loss of competitiveness of the port of Fortaleza subsequently was recovered. We conclude that the ports are specializing and becoming complementary ports.
O Plano de Governo do Cearà (1987-1990) destacava como eixo econÃmico para o Cearà a expansÃo industrial com a instalaÃÃo de novas plantas com escala de produÃÃo elevada. NÃo explicitava claramente, no entanto, a implantaÃÃo de um novo porto e sim a expansÃo do porto de Fortaleza para consolidar a sua integraÃÃo com o Distrito Industrial de PajuÃara. Com a polÃtica estadual de fortalecimento da economia local, porÃm, com viÃs para o mercado externo, surgiu a necessidade de construÃÃo de um novo complexo portuÃrio. Assim, em 1995, apareceu a ideia de construir outro porto com localizaÃÃo afastada dos centros urbanos, com infraestrutura capaz de viabilizar um parque industrial metalmecÃnico e petroquÃmico, especialmente com um terminal portuÃrio moderno em condiÃÃes de oferecer operaÃÃes eficientes, com tarifas competitivas e acessos rodoviÃrios livres. Inaugurado em 2002, o Complexo Industrial e PortuÃrio do PecÃm foi modelado para atender a demanda de cargas gerais e contÃineres e ser incluÃndo na rota marÃtima internacional de navios de grande porte. Certamente, a criaÃÃo do Complexo Industrial e PortuÃrio do PecÃm impactou a corrente de comÃrcio cearense e modificou a movimentaÃÃo de mercadorias do porto de Fortaleza. Nesse sentido, este estudo tem como objetivo verificar o nÃvel de competitividade do porto de Fortaleza em confronto com o porto do PecÃm. Busca-se, deste modo, examinar a hipÃtese de complementariedade das atividdes dos dois portos. A metodologia utilizada consiste da interpretaÃÃo de estatÃsticas descritivas sobre a corrente de comÃrcio e, em termos analÃticos, do uso de indicadores de vantagem competitiva revelada, na tradiÃÃo de Balassa(1965). Os resultados mostram que parcela relevante dos principais produtos importados e exportados pelo porto de Fortaleza foi absorvida pelo porto do PecÃm, mas que, ao longo da sÃrie analisada, se verificou uma retomada significativa da movimentaÃÃo do porto de Fortaleza. AlÃm disso, constatou-se certa especializaÃÃo em relaÃÃo aos blocos econÃmicos, seja no aspecto da exportaÃÃo ou da importaÃÃo. Ficou evidenciado que a perda inicial de competitividade do porto de Fortaleza foi sequencialemnte recuperada. Conclui-se que os portos estÃo se especializando e se transformando em portos complementares.
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O'Dwyer, Michael Olivier. « Le peche dans l'oeuvre romanesque et dramatique de julien green ». Paris 3, 1986. http://www.theses.fr/1986PA030091.
Texte intégralRésumé :
Notre etude nous a permis de distinguer quatre etapes dans la formulation de la notion du peche chez green. Dans la premiere etape (1926-1934), il s'agit d'une etude de plusieurs expressions du pharisaisme une mentalite qui met l'accent sur la lettre de la loi, tout en laissant de cote la motivation qui definit l'acte moral. Les peches depeints sont ; la priere formaliste, l'usurpation de la place de dieu en jugeant autrui, l'avarice et l'exploitation d'autrui. Green souligne l'aspect juridique du peche. Dans la deuxieme etape (1940-1947), green presente le peche sous son aspect ontologique. C'est une intellectualisation du sujet, une evolution vers une "theologie". Il decrit l'orgueil intellectuel et le role du diable. Il note la liberte et la responsabilite chez l'homme et les aspects psychologiques du peche comme la solitude, l'ennui, et la rupture avec autrui. Dans la troisieme etape (1950-1960), green presente une analyse du temperament scrupuleux et du peche de la chair. Nous avons affaire a la formation de la conscience du peche chez un jeune homme eleve dans un milieu conformiste et cruel. La vision du peche est negative. Du cote divin, il y a la colere de dieu. Du cote humain, il presente le peche en termes de culpabilite, de scrupulosite et de remords. Dans la quatrieme etape (1960-1971), la vision greenienne est plus optimiste. Le peche permet a l'homme de prendre conscience non seulement de la profondeur de ses defaillances, mais aussi de la grandeur de ses aspirations. Nous remarquons aussi une appreciation de l'amour de dieu pour le pecheur qui se fait sentir a travers les sacrements. L'eglise devient intermediaire de la misericorde de dieu. Finalement, nous avons constate que c'est bien en artiste que green a presente la notion du pecheThis thesis identifies four stages in the formulation of the notion of sin in the works of julien green. In the first stage (1926-1934), green examines several aspects of hypocrisy, a mentality which emphasises the letter of the law, while ignoring the inner motives which define the moral act. Sins studied by green are ; formalism in the practice of religion, abuse of the prayer of petition, avarice, exploitation and various abuses of justice and charity. Green underlines the legal dimension of sin. In the second stage (1940-1947) green examines sin from an ontological viewpoint. An evolution towards a "theology" of sin can be noted. Green focuses on intellectual pride and on the role of satan. He draws attention to man's freedom and responsibility as well as the psychological effects of sin such as isolation, ennui and a sense of void at the core of the sinner's being. In the third stage (1950-1960), green analyses the scrupulous temperament, in regard to sins relating to sexuality. He illustrates the consequences for a conscience formed in a strict conformist environment. The image of divinity is one of cruelty. From a human viewpoint, green underlines guilt, scrupulosity and remorse. In the fourth stage (1960-1971), an optimistic vision of sin emerges. While giving man an insight into his weakness, the experience of sin also provides an awareness of the depth of his aspirations. We notice an awareness of the mercy of christ as well as an appreciation of the love of god communicated through the sacrements. The church mediates the love of god to man. Finally, we concluded that green's presentation of sin was successful from an artistic viewpoint
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Martins, Vera Lúcia Freire. « Competitividade revelada entre os portos de Fortaleza e do Pecém ». reponame:Repositório Institucional da UFC, 2009. http://www.repositorio.ufc.br/handle/riufc/5738.
Texte intégralRésumé :
MARTINS, Vera Lúcia Freire. Competitividade revelada entre os portos de Fortaleza e do Pecém. 2009. 69f. Dissertação (mestrado profissional) - Programa de Pós Graduação em Economia, CAEN, Universidade Federal do Ceará, Fortaleza, CE, 2009.Submitted by Mônica Correia Aquino (monicacorreiaaquino@gmail.com) on 2013-09-04T20:39:54Z No. of bitstreams: 1 2009_dissert_vlfmartins.pdf: 580269 bytes, checksum: a764e2071143cfc1f2d70b9c5151a10a (MD5)
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The Plan of Government of Ceará (1987-1990) highlighted how economic hub for Ceará industrial expansion with the installation of new plants with high production scale. Failed to explain clearly, but the deployment of a new port, but to expand the port of Fortaleza to consolidate its integration with Industrial District Pajuçara. With the state policy of strengthening the local economy, but with bias to the external market, the need arose to build a new port complex. Thus, in 1995, appeared the idea of building another port located away from urban centers, with infrastructure capable of providing an industrial metal and petrochemicals, especially with a modern port terminal in a position to offer efficient operations at competitive rates and access roads Free. Opened in 2002, the Industrial and Port Complex Pecém was modeled to meet the demand for general cargo and containers and be included in the international sea route large ships. Indeed, the creation of the Industrial and Port Complex Pecém impacted the trade flow from Ceará and modified the movement of goods from the port of Fortaleza. Thus, this study aims to determine the level of competitiveness of the port of Fortaleza in confrontation with the port of Pecém. Search is thus to examine the hypothesis of complementarity of the activities of the two ports. The methodology consists of the interpretation of descriptive statistics about trade flows and, in analytical terms, the use of indicators of revealed competitive advantage in the tradition of Balassa (1965). The results show that relevant portion of the main products imported and exported through the port of Fortaleza was absorbed by the Port of Pecém, but that over the study period, there was a significant recovery drive from the port of Fortaleza. Moreover, it appeared certain specialization in relation to economic blocs, whether in respect of export or import. Showed that the initial loss of competitiveness of the port of Fortaleza subsequently was recovered. We conclude that the ports are specializing and becoming complementary ports.
O Plano de Governo do Ceará (1987-1990) destacava como eixo econômico para o Ceará a expansão industrial com a instalação de novas plantas com escala de produção elevada. Não explicitava claramente, no entanto, a implantação de um novo porto e sim a expansão do porto de Fortaleza para consolidar a sua integração com o Distrito Industrial de Pajuçara. Com a política estadual de fortalecimento da economia local, porém, com viés para o mercado externo, surgiu a necessidade de construção de um novo complexo portuário. Assim, em 1995, apareceu a ideia de construir outro porto com localização afastada dos centros urbanos, com infraestrutura capaz de viabilizar um parque industrial metalmecânico e petroquímico, especialmente com um terminal portuário moderno em condições de oferecer operações eficientes, com tarifas competitivas e acessos rodoviários livres. Inaugurado em 2002, o Complexo Industrial e Portuário do Pecém foi modelado para atender a demanda de cargas gerais e contêineres e ser incluíndo na rota marítima internacional de navios de grande porte. Certamente, a criação do Complexo Industrial e Portuário do Pecém impactou a corrente de comércio cearense e modificou a movimentação de mercadorias do porto de Fortaleza. Nesse sentido, este estudo tem como objetivo verificar o nível de competitividade do porto de Fortaleza em confronto com o porto do Pecém. Busca-se, deste modo, examinar a hipótese de complementariedade das atividdes dos dois portos. A metodologia utilizada consiste da interpretação de estatísticas descritivas sobre a corrente de comércio e, em termos analíticos, do uso de indicadores de vantagem competitiva revelada, na tradição de Balassa(1965). Os resultados mostram que parcela relevante dos principais produtos importados e exportados pelo porto de Fortaleza foi absorvida pelo porto do Pecém, mas que, ao longo da série analisada, se verificou uma retomada significativa da movimentação do porto de Fortaleza. Além disso, constatou-se certa especialização em relação aos blocos econômicos, seja no aspecto da exportação ou da importação. Ficou evidenciado que a perda inicial de competitividade do porto de Fortaleza foi sequencialemnte recuperada. Conclui-se que os portos estão se especializando e se transformando em portos complementares.
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Souza, Heverson Inamar Araújo de. « Logística Portuária : Análise "S.W.O.T" dos portos do Mucuripe e Pecém ». reponame:Repositório Institucional da UFC, 2017. http://www.repositorio.ufc.br/handle/riufc/25961.
Texte intégralRésumé :
SOUZA, Heverson Inamar Araújo De. Logística Portuária: Análise “S.W.O.T.” dos Portos do Mucuripe e Pecém / Heverson Inamar Araújo de Souza. – 2017. 84 f. Dissertação (mestrado profissional). - Universidade Federal do Ceará, Programa de Pós Graduação em Economia, CAEN, Fortaleza, 2017.Submitted by Mônica Correia Aquino (monicacorreiaaquino@gmail.com) on 2017-09-19T22:11:41Z No. of bitstreams: 1 2017_dis_hiasouza.pdf: 1218018 bytes, checksum: 0c4846c08640917c303a57580b0d3bf0 (MD5)
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The maritime world trade has followed a vertiginous growth and integration of several global industries, which in their search for the optimization of their processes, efficiency and consequent general reduction of costs, creates an environment of fierce competition between the players of their logistics chains. The ports, as essential transit points of the international trade have obviously been inserted in this context. Within this commerce atmosphere, it is of utmost importance the constant and attentive observation of the particular performance of each business, product and services offered. It is important to be fully aware of own strengths, weakness, new opportunities, as well as the constant threats launched either by the competitors, or by the cycle of life of products and services shorter each day. This paper intends to lecture about the main concepts of the logistics of the ports, their players, the ports of Mucuripe (Fortaleza) and the Industrial and Port Complex of Pecém, their history, motivation, main characteristics, nevertheless with the main objective to appoint their competitive advantages and disadvantages, by means of the SWOT analysis. In the end, we have considered that the terminal of Pecém and the port of Mucuripe, despite their peculiarities, hold an intersection with regard the services they render and their competitive advantages, either due to the geographical proximity, or the pressure of the maritime market with larger ships and consequent demand by better logistics processes, or by the delay on the implementation of their main projects, we mean the first, with the refinery and the steel mill, which has been led to adapt to what has been offered by the market, like the general cargo in containers, the solid (mineral coal and iron ore) and liquid bulk (GNL) and then follow a track that sometimes conflicts with its initial purpose and led to a direct competition with the port of Mucuripe in Fortaleza.
O comércio marítimo mundial tem acompanhado o crescimento e a integração vertiginosa das várias indústrias globais, que na busca por otimização dos processos, eficiência e consequente redução de custos, gera um ambiente de acirrada competição entre todos os atores envolvidos em suas cadeias logísticas. Os portos como pontos de transito essenciais no fluxo de comércio entre as nações são obviamente inseridos nesse contexto. Nessa atmosfera de comércio, faz-se necessária a constante e atenta observação do desempenho particular de cada negócio, produtos e serviços oferecidos. É importante estar completamente ciente de suas potencialidades, fraquezas, das novas oportunidades, bem como as constantes ameaças, seja pelos competidores, seja pelos ciclos de vida dos produtos e serviços cada vez mais curtos. O presente trabalho pretende dissertar sobre os principais conceitos da logística portuária, seus atores, sobre os portos do Mucuripe (Fortaleza) e do Complexo Industrial e Portuário do Pecém, seus históricos, motivação que lhes deu origem, principais características, porém tendo como objetivo principal apontar suas vantagens e desvantagens competitivas e utiliza para tanto a análise SWOT (PFOA). Ao final, consideramos que o terminal do Pecém e o porto do Mucuripe, apesar de suas características peculiares, possuem intersecção de oferta de serviços e vantagens competitivas, seja pela proximidade geográfica, seja por pressão do mercado marítimo, com navios maiores e consequente demanda por melhores processos logísticos, ou mesmo pelo atraso na implementação dos seus projetos âncoras, no caso o primeiro, com a refinaria e siderúrgica, o qual foi levado a adaptar-se ao que o mercado ofertava, a carga geral em containers, o granel sólido (carvão e minério de ferro) e líquido (GNL) e então seguir um caminho que por vezes conflita com seu propósito inicial e o leva a competir de forma direta com o porto do Mucuripe em Fortaleza .
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Boyd, Carolyn E. « The work of art : rock art and adaptation in the lower Pecos, Texas Archaic / ». Ann Arbor (Mich.) : UMI dissertation services, 1999. http://catalogue.bnf.fr/ark:/12148/cb400202055.
Texte intégral
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Deusdará, Cristiane Eleutério Carvalho. « A implantação do complexo industrial e portuário do Pecém e seus reflexos sobre o desenvolvimento local do Município de São Gonçalo do Amarante ». reponame:Repositório Institucional da UFC, 2013. http://www.repositorio.ufc.br/handle/riufc/6391.
Texte intégralRésumé :
DEUSDARÁ, Cristiane Eleutério Carvalho. A implantação do complexo industrial e portuário do Pecém e seus reflexos sobre o desenvolvimento local do Município de São Gonçalo do Amarante. 2013. 50 f. Dissertação (mestrado profissional em economia do setor público) - Programa de Pós Graduação em Economia, CAEN, Universidade Federal do Ceará, Fortaleza-CE, 2013.Submitted by Mônica Correia Aquino (monicacorreiaaquino@gmail.com) on 2013-10-24T22:25:52Z No. of bitstreams: 1 2013_dissert_cecdeusdara.pdf: 1509762 bytes, checksum: e217b56f96e64e533310bec899fa5434 (MD5)
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This study aims to analyze the development of São Gonçalo do Amarante due to the implementation of Industrial and Port Complex of Pecém. Initially, it is made an approach at a conceptual level of Local Economic Development, highlighting some important aspects related to this subject. It should be noted that local government has an important role in the development process getting, excessively, practicable solutions to the socioeconomic problems of the community in search of partnerships between the public and private sectors and society. In this perspective, we seek to show clearly that the decision to build a new enterprise of the size of Industrial and Port Complex of Pecém brought significant impacts to the development of the Municipal District of São Gonçalo do Amarante. The specific reference of this work derives in function of harbour and the largest part of Industrial Complex are located in that territorial area. Finally, this dissertation seeks to highlight, at the light of facts and data, the resultant reflexes from such an enterprise in that municipality.
Este trabalho tem por objetivo fazer uma análise do desenvolvimento do Município de São Gonçalo do Amarante em decorrência da implantação do Complexo Industrial e Portuário do Pecém. Inicialmente, é feita uma abordagem, em nível conceitual, de Desenvolvimento Econômico Local, destacando-se alguns aspectos associados a esse tema. cumpre ressaltar que o governo local tem um papel relevante no processo de desenvolvimento obtendo, sobremaneira, soluções viáveis para os problemas socioeconômicos da comunidade, em busca de parcerias entre os setores público e privado e a sociedade. Nessa perspectiva, procura-se evidenciar que a decisão de construção de um empreendimento do porte do Complexo Industrial e Portuário do Pecém trouxe impactos significativos ao desenvolvimento do Município de São Gonçalo do Amarante. A referência específica deste trabalho a esse município decorre em função do Porto e da maior parte do Complexo Industrial estarem localizados naquela área territorial. Por fim, esta dissertação procura destacar, à luz de fatos e dados, os reflexos decorrentes de tal empreendimento naquele município.
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Paiva, Amarilis Brandão de. « Estudo comparativo das assembleias de ascidias em duas regiões portuárias da costa brasileira ». reponame:Repositório Institucional da UFC, 2013. http://www.repositorio.ufc.br/handle/riufc/13954.
Texte intégralRésumé :
PAIVA, A. B. de. Estudo comparativo das assembleias de ascidias em duas regiões portuárias da costa brasileira. 2013. 86 f. Dissertação (Mestrado em Ciências Marinhas Tropicais) - Instituto de Ciências do Mar, Universidade Federal do Ceará, Fortaleza, 2013.Submitted by Nadsa Cid (nadsa@ufc.br) on 2015-11-12T20:25:50Z No. of bitstreams: 1 2013_dis_abdepaiva.pdf: 2539144 bytes, checksum: 02eaf6062ba30b8a2b146c0c8f1ad616 (MD5)
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The intensification of the maritime transport around the world is coupled with an increase in the harbors and dockings infrastructure. These structures provide hard substrata for a generally abundant and diverse encrusting fauna. It has been demonstrated that artificial substrata in ports and marinas may harbor a considerable amount of exotic species. Ascidians are among the most important groups in such environments, being transported in the hulls or ballast water of ships connecting different regions. The present study investigate the assemblage of ascidians encrusting settling plates in two different harbor areas, distant more than 20º of latitude along the Brazilian coast. The polystyrene settling plates measured 12 x 12 cm were arranged in pairs, forming a “sandwich” with a 2cm space between them, and were kept submerged for periods of three months and one year, while the experiment lasted two years. The species richness of both areas was just slightly different (33 species in Ceará and 31 in São Paulo). On the other hand, Ceará presented a larger species richness per plate than São Paulo. In São Paulo, at the limit of the tropics, a stronger influence of seasonality was detected in terms of species composition between different periods. The compositions of the assemblages from the plates submerged for three months and one year was also different. The assemblage recruiting the internal and external faces of the plates sets were also different in terms of specific composition. The yearly plates presented a lower coverage of ascidians when compared to the quarterly plates, with a corresponding increase in coverage for other groups such as sponges and bryozoans. The internal faces of yearly plates showed a greater abundance of solitary ascidians, mainly Ascidia sydneiensis. The species Rhodosoma turcicum was recorded for the first time in the northern Brazilian coast. The presence of many exotic or cryptogenic species at the studied areas highlights the importance of continuous regular monitoring of the encrusting fauna in harbors and marinas.
A intensificação do transporte marítimo ao redor do mundo vem aumentando junto com a infraestrutura de áreas portuárias. Estas estruturas proporcionam substratos rígidos que passam a abrigar uma fauna incrustante, em geral, rica e abundante. Já se demonstrou que substratos artificiais nestas áreas podem abrigar um contingente considerável de espécies exóticas. Dentre os grupos que recrutam em tais ambientes, as ascídias se destacam, podendo ser transportadas por navios entre diferentes regiões, tanto por água de lastro como por incrustações nos cascos. Neste trabalho foi realizado um levantamento das assembleias de ascídias que incrustam em placas de recrutamento artificiais, em duas regiões portuárias com mais de 20º de diferença latitudinal na costa brasileira. Os experimentos foram realizados no Porto do Pecém – CE e em uma marina no canal de São Sebastião – SP. Foram utilizados pares de placas de polietileno (12 x 12 cm), espaçadas em 2 cm formando “sanduíches”, submersas por períodos de três meses e de um ano para verificar o recrutamento da comunidade incrustante. O experimento teve duração de dois anos. A riqueza de ascídias encontrada em cada local não foi muito diferente (33 espécies no Ceará e 31 em São Paulo). No entanto, o Ceará, região de menor latitude, apresentou uma maior riqueza por placa. Em São Paulo, latitude subtropical, verificou-se uma maior influência da sazonalidade na composição das espécies dos diferentes períodos. Foram observadas diferenças nas composições das placas de três meses com as de um ano de submersão e também diferenças na composição das assembleias de ascídias nas faces internas e externas dos pares de placas. Comparando as placas trimestrais e anuais, foi detectada uma menor porcentagem de cobertura pelas ascídias nas placas anuais externas, ocorrendo aumento de outros grupos, principalmente esponjas e briozoários. Nas faces internas das placas anuais ocorre aumento da abundância de ascídias solitárias, principalmente da espécie Ascidia sydneiensis. A presença da ascídia Rhodosoma turcicum em placas do Ceará caracterizou o primeiro registro desta espécie para o nordeste setentrional brasileiro. A presença de muitas espécies exóticas e criptogênicas nas regiões de estudo alerta para a importância de monitoramentos contínuos das espécies em regiões portuárias.
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Emsley, Stephen Michael. « PECOS : towards an object-orientated virtual ecology of plankton population dynamics ». Thesis, University of Warwick, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.364627.
Texte intégral
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Novotný, Jan. « Zakládací zařízení do víceetážové pekárenské pece ». Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2020. http://www.nusl.cz/ntk/nusl-416617.
Texte intégralRésumé :
This thesis is aimed at the design of a loading device for a multi-storey bakery oven, which is going to be located in a bread production line. The introduction describes a principle of operation of the bread line and defines the parameters of the device. Furthermore, the hygienic, design and material requirements for the machines which are used in a food industry are briefly stated. Next part summarizes the possibilities of design solutions and the chosen concept. The construction part is aimed at the design of the conveyor and the scissor mechanism. In the calculation part, a static calculation of the lifting mechanism and a strength check of its arms and pins is performed. This thesis also includes the design of a hydraulic circuit for a stroke drive. Finally, the method of a control of the stacker and its safety elements are discussed.
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Roberts, Samantha. « PECAM-1 expression by mesenchymal stromal cells is regulated by Notch signalling ». Thesis, University of Manchester, 2014. https://www.research.manchester.ac.uk/portal/en/theses/pecam1-expression-by-mesenchymal-stromal-cells-is-regulated-by-notch-signalling(1259846d-df3b-43c3-8ce0-d25135ccdedd).html.
Texte intégralRésumé :
Mesenchymal stromal cells (MSCs) reside within the perivascular niche and have been shown in vivo to facilitate vascular repair. Previous in vitro studies, have demonstrated the potential of MSCs to differentiate towards an endothelial lineage, when cultured at high cell density; but the characterisation of these cells and the mechanisms directing this important differentiation effect are ill-defined. To resemble a three-dimensional (3D) cellular environment, MSCs were cultured as spheroids and the endothelial characteristics of these cells determined. MSCs cultured as spheroids significantly increased their expression of the endothelial markers; PECAM-1, Tie2, VE-cadherin and vWF, when compared to MSCs cultured in close cell contact as a two-dimensional (2D) monolayer. In addition, MSCs cultured as 3D spheroids behaved as functional endothelial cells in vitro; including the ability to uptake low-density lipoproteins, secretion of nitric oxide and the ability to form network-like structures. MSC spheroids exhibited significantly increased levels of Notch signalling, compared to 2D MSCs in close cell contact, which caused a significant decrease in the endothelial characteristics when inhibited. Conversely, activation of Notch signalling caused a significant and specific increase in the expression of PECAM-1, which was regulated by the Notch ligands Jagged1 and DLL4. Thus, Notch signalling is a crucial pathway that controls PECAM-1 expression and regulates the angiogenic fate of MSCs within spheroids. This study has therefore identified an efficient culture model and key signalling mechanism which may be used to induce MSCs towards an angiogenic fate for vascular repair and regeneration therapies.
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Juda, Lukáš. « Zařízení pro zásyp odpichového otvoru obloukové pece ». Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2015. http://www.nusl.cz/ntk/nusl-232163.
Texte intégralRésumé :
Diploma thesis describes design and function verification of device for filling tap hole of electric arc furnace with tap hole diameter from 190 mm to 250 mm. The theses includes drive design calculation of chute swinging movement and bearing calculations. Another part of the thesis deals with verification of device functions which it is completed with process description of creating DEM simulation in program YADE. The thesis also includes basic experiments for determination angle of internal friction, angle of repose, coefficient of restitution and angle of material friction on a steel surface. Drawing documentation of selected assemblies is part of the thesis.
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Galková, Kristína. « Technicko-ekonomická studie hlavního hořáku rotační pece ». Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2021. http://www.nusl.cz/ntk/nusl-443185.
Texte intégralRésumé :
This master's thesis talks about main burners of clinker rotary kiln. The first part is focused on the review of burners designed by main global producers. Description of the burners M.A.S.© and Turbu-Flex™ used in kiln system CEMMAC a.s. is in the next part. The influence of the replacement of M.A.S.© burner by Turbu-Flex™ burner is analysed in the last part of this thesis.
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Dobai, Szabolcs. « Rekuperace tepla z odpadních plynů tavicí pece ». Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2019. http://www.nusl.cz/ntk/nusl-400518.
Texte intégralRésumé :
This master’s thesis deals with the design of heat recovery system from melting furnace waste gases. The first part is devoted to a brief description of heat exchangers, with the special importance being placed on the shell-and-tube heat exchanger. The second part contains a calculation of stoichiometric combustion, design of geometrical dimensions, calculation of pressure drops and power. At the end of the thesis there are various possibilities of utilization of the obtained waste heat and their basic economic assessment.
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Trachta, Jiří. « Optimalizace provozu indukční pece ve slévárně Vsetín ». Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2011. http://www.nusl.cz/ntk/nusl-219082.
Texte intégralRésumé :
The aim of this work is optimalisation of induction furnace in foundry for company PROMET FOUNDRY a.s. The company has two induction furnances. There are installed as identical construction. They have 2 modes of operation. First mode is founding and second mode is mode, where is temperature in maintain mode. Only one induction furnance can work in the founding mode at a time though. Inducion furnances are in the single-phase connection and they cause unbalance in the distribution network. Near the foundry there is a small network area whitch it is operated by company Zásobování teplem Vsetín a.s. The consumption of electrical energy in foundry so big, that in the year 2009 was made elaborate for Zásobování teplem Vsetín a.s. It was write at Laboratoře diagnostiky výkonů (Laboratory of performance diagnostics), which is a part of Electrotechnic Department at Technical Univarsity of Ostrava. The ordered study was named “Verification of causes of increased reactive energy consumption during transition from electricity delivery to electricity consumption”. The conclusion of this assignment confirms that in distribution network in the Jiráskova area in Vsetín there is unbalance of electrical energy and there is high part of reactive power. The next conclusion is crucial to find the customer who made the unbalance and to set relevant remedy. The last step will be the identification whether such device can actually be effectively balanced. It was subsequently proved that the Promet Foundry was causing the unbalance and that balanced consumption would be reasonable. Promet Foundry thus addressed Autel a.s. company with an inquiry to make a study of removing the causes of the unbalance which is caused by current induction furnaces operation at a minimum possible cost, least possible influence on the performance and minimum construction changes concerning the building. In this thesis there will be some topics. The result of which will be introducing of used heating technology, introducing of company and of effective plant performance and subsequent suggestions of possible unbalance removal or reactive power decrease. Several ways which are being implemented in the industry in order to balance consumption will be described. A suitable balancing plant will be subsequently chosen and its parameters will be calculated.
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Bezerra, Luis Artur Valões. « Influência da variação temporal no controle das teias tróficas em reservatório que abastece o complexo portuário do Pecém (CE) ». reponame:Repositório Institucional da UFC, 2015. http://www.repositorio.ufc.br/handle/riufc/19390.
Texte intégralRésumé :
BEZERRA, L. A. V. Influência da variação temporal no controle das teias tróficas em reservatório que abastece o complexo portuário do Pecém (CE). 2015. Dissertação (Mestrado em Ciências Marinhas Tropicias) - Instituto de Ciências do Mar, Universidade Federal do Ceará, Fortaleza, 2015.Submitted by Geovane Uchoa (geovane@ufc.br) on 2016-09-01T12:29:22Z No. of bitstreams: 1 2015_dis_lavbezerra.pdf: 1387225 bytes, checksum: 13a1dbb8f64f112590eada934c54ec1b (MD5)
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As variações climáticas em ecossistemas do semiárido, ligadas ao controle de teia trófica (top-down, bottom-up, wasp-waist, alternado) são questões-chave para melhorar o manejo da pesca e de ecossistemas aquáticos. Nesse estudo, o papel das chuvas e da estiagem prolongada são simulados no reservatório Sítios Novos, localizado no semiárido brasileiro,considerando teias tróficas compostas espécies nativas e exóticas. Para isso, foram desenvolvidos modelos em períodos de chuvas, estiagem e estiagem prolongada, utilizando o software Ecopath with Ecosim (EwE). O reservatório Sítios Novos está localizado no estado do Ceará, com 16,48 km² e 126,10 m³. Espécies de peixes, tais como Oreochromis niloticus, Atherinella brasiliensis, Cichla monoculus, Plagioscion squamosissimus e Arapaima gigas foram introduzidas nesse ambiente artificial para incrementar a pesca artesanal, exercida em média, por 16 pescadores, ao dia. Os peixes e invertebrados foram amostrados no reservatório por “arrastos de praia” padronizados, rede de plâncton, garrafa Kemmerer e draga de Ekman. Aves foram inventariadas no reservatório e identificadas por especialistas. Os grupos-chave foram peixes, principalmente C. monoculus adulto, A. brasiliensis juvenil e O. niloticus adulto e juvenil. O maior consumo é exercido pelo nível trófico II, em que a detritivoria é duas vezes superior à herbivoria. As interações tróficas de A. brasiliensis juvenis e O. niloticus adultos representam a influência positiva de grupos tróficos intermediários sobre a dieta do predador de topo C. monoculus, considerada do tipo wasp-waist. A sustentação do ecossistema é baseada em fitoplâncton e principalmente detritos, uma vez que o primeiro chega a ter sua biomassa constituída por 96% de cianobactérias. A elevada produtividade fitoplânctonica neste reservatório favorece o controle da teia trófica por C. monoculus, A. brasiliensis e O. niloticus. Ademais, as chuvas ocorreram como um evento natural que provoca um distúrbio sobre a teia trófica exótica, com uma resiliência de 17,05 ton.km-2 .ano -1 . A prolongada estiagem (de 2010 a 2015) intensifica o controle top-down exercido por Cichla sp. e pela pesca no ecossistema, especialmente as interações wasp-waist.
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SILVA, M. A. « CARACTERIZAÇÃO HISTOPATOLÓGICA E IMUNOISTOQUÍMICA DE BEXIGAS DE BOVINOS COM HEMATÚRIA ENZOÓTICA ». Universidade Federal do Espírito Santo, 2012. http://repositorio.ufes.br/handle/10/5101.
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Previous issue date: 2012-02-27A hematúria enzoótica bovina (HEB) é causada pela ingestão crônica de Pteridium aquilinum e caracteriza-se pela presença de sangue na urina e desenvolvimento de lesões na bexiga, sendo responsável por grandes perdas econômicas. A intoxicação por esta planta também pode ocorrer em humanos. Objetivou-se avaliar lesões de bexigas de animais com HEB na região sul do Espírito Santo. Para isto, foram avaliadas 350 bexigas de bovinos em matadouro frigorífico e, destas, selecionadas 46 que apresentavam lesões macroscópicas e/ou hematúria. Amostras de cada bexiga foram fixadas em formol a 10% submetidas ao processamento histológico de rotina e classificadas histomorfologicamente. A imunoistoquímica foi realizada com anti-vimentina, anti-citoqueratina, anti-CD31, anti-VEGF e anti-uroplaquina apenas nas 26 bexigas que revelaram neoplasia. Lesões não neoplásicas foram observadas em 100% das amostras e neoplásicas em 56,52%. A presença de neoplasias foi significativa (p<0,05) na porção caudal da bexiga. As neoplasias encontradas foram carcinoma urotelial; carcinoma in situ, adenocarcinoma, hemangioma, mixoma e hemangiossarcoma. Houve maior frequência de displasia, metaplasia de células claras, inflamação e espessamento vascular em bexigas com neoplasia. A expressão de citoqueratina foi significativa (p<0,05) nas neoplasias epiteliais e vimentina nas mesenquimais. A marcação da uroplaquina III diferiu nos diversos tipos neoplásicos e revelou-se típica e atípica enquanto que a do CD31 foi significativa (p<0,05) nas neoplasias mesenquimais vasculares. Houve diferença significativa (p<0,05) na quantidade de vasos extratumorais marcados pelo VEGF entre os mixomas e adenocarcinomas e nos vasos intratumorais marcados por CD31 e VEGF nos diferentes tipos tumorais. Houve correlação positiva entre os vasos extra e intratumorais nos hemangiomas, hemangiossarcomas e mixomas marcados pelo CD31; nos hemangiomas, mixomas e adenocarcinomas marcados pelo VEGF; entre a expressão de vimentina e CD31 e entre citoqueratina e uroplaquina. Conclui-se que bexigas de bovinos com HEB apresentam lesões não neoplásicas e neoplásicas, isoladas ou associadas. Os biomarcadores auxiliam na diferenciação da histogênese das neoplasias epiteliais e mesenquimais vasculares. Uroplaquina demonstrou-se efetiva para a avaliação da integridade urotelial e os marcadores vasculares (CD31 e VEGF) para a integridade endotelial e para o prognóstico.
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Wagner, Erin K. « Linguam ad Loquendum : Writing a Vernacular Identity in Medieval and Early Modern England ». The Ohio State University, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=osu1429013712.
Texte intégral
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Cicmil, Milenko. « Platelet endothelial cell adhesion in molecule -1 (PECAM-1/CD31) signalling in platelets ». Thesis, University of Reading, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.270922.
Texte intégral
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Aderaldo, JanaÃna Ferreira. « Complexo industrial e portuÃrio do PecÃm : promoÃÃo ou ameaÃa ao desenvolvimento sustentÃvel regional ? » Universidade Federal do CearÃ, 2012. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=9804.
Texte intégralRésumé :
CoordenaÃÃo de AperfeiÃoamento de Pessoal de NÃvel SuperiorA crescente escassez de recursos naturais e maior ocorrÃncia de desastres ambientais fomentaram o debate acerca da importÃncia de analisar previamente as consequÃncias da pressÃo antrÃpica exercida e, neste cenÃrio histÃrico ganhou forma e valia o conceito de desenvolvimento sustentÃvel, que provÃm da reavaliaÃÃo crÃtica da relaÃÃo existente entre a sociedade e seu meio natural e artificial. Mesmo sendo unÃnime o reconhecimento da importÃncia dos indicadores para mensurar o desenvolvimento sustentÃvel, à difÃcil acreditar que haverà alguma fÃrmula de ampla aceitaÃÃo, devido à existÃncia de sÃrias clivagens e bloqueios, tanto conceituais quanto operacionais. Dentre os programas governamentais que visam corrigir as distorÃÃes em todas as dimensÃes, foi elaborado no Cearà o Plano de Desenvolvimento SustentÃvel â PDS do governo estadual, que incorporou a noÃÃo sustentabilidade em seus planos de desenvolvimento a partir de 1995. Esse plano apresentou como objetivo a melhoria na qualidade de vida da populaÃÃo no espaÃo temporal de 25 anos e gerou expectativas de reduÃÃo das desigualdades sociais. Uma das metas presentes no PDS do governo cearense foi a implantaÃÃo do Complexo Industrial e PortuÃrio do PecÃm â CIPP, projeto estadual estruturante que tem como objetivo viabilizar a operaÃÃo de atividades portuÃrias e industriais integradas, imprescindÃveis ao desenvolvimento. Dado o exposto, surgiu o questionamento do modelo de desenvolvimento pretendido pelo Poder PÃblico, cujo discurso define como sustentÃvel, pois este estudo buscou avaliar de que forma o modelo de desenvolvimento proposto e financiado pelo governo no municÃpio de SÃo GonÃalo do Amarante estimula o desenvolvimento. Observou-se que a polÃtica de atraÃÃo de investimentos priorizou os setores industrial e de serviÃos, dentre outras iniciativas, que promoveram, tambÃm, sÃrios problemas sociais (Ãxodo rural, falta de moradia nas cidades, falta de saneamento bÃsico) e ambientais (desmatamento, perda da biodiversidade, comprometimento dos recursos hÃdricos) alÃm de intensificar ainda mais as desigualdades entre as regiÃes urbana e rural ao diminuir as perspectivas de emprego no campo. Sugere-se a adoÃÃo de medidas corretivas possÃveis, como o ordenamento da urbanizaÃÃo, capacitaÃÃo profissional de qualidade para populaÃÃo local, implantaÃÃo de medidas fomentadoras de prÃticas culturais e econÃmicas de carÃter dinÃmico, adoÃÃo de tecnologia limpa em todas as Ãreas de atuaÃÃo como engenharia, arquitetura, transporte, etc.
The growing shortage of natural resources and a greater occurrence of environmental disasters heat up the debate about the importance of previously analysing the consequences of the anthropic pressure made and critically reevaluate the relation between society and its natural and artificial environment in this historical setting, in which the concept of sustainable development takes shape and importance. Even though it is acknowledged the importance of indicators to measure the sustainable development, it is hard to believe that there will be some formula of wide acceptation due the existence of serious operational and conceptual rifts and blocks. Among the governmental programs that aim to correct distortions in all dimensions, it was elaborated, in CearÃ, the plan of sustainable development â PSD of the state government. This plan incorporated the notion of sustainability in its development plans since 1995 and presented as goal the improvement of the quality of life of the population in period of time of 25 years, raising expectations of reduction of social inequalities. One of the goals in the Cearense government PSD is the implementation of the PecÃm Industrial Port Complex â CIPP, a structutural state project that has the objective to make the operation of integrated industrial and portuary activities possible, paramount to the development. In the light of the above, the questioning to the developmental model proposed by the government came up, which discourse defines the model as sustainable. This is study aims to analyze how the developmental model proposed and financed by the government of the municipality of SÃo GonÃalo do Amarante encourages the so called sustainable development. It has been observed that the investment attraction policy has placed a high priority on the service and industrial sectors, among other initiatives, which also promoted serious social (rural exodus, homelessness, lack of basic sanitation.) and environmental (defloration, loss of biodiversity, damage to water resources) problems. In addition, it has intensified even more the inequalities between the urban and rural regions for having diminished the prospects for employment in the countryside. It is suggested the adoption of possible corrective measures, as the planning of urbanization, good professional training for the local population, implementation of measures that encourage cultural and economical practices with dynamic nature, adoption of clean technology in all areas of operation, such as engineering, architecture, transportation, etc.
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Aderaldo, Janaína Ferreira. « Complexo industrial e portuário do Pecém : promoção ou ameaça ao desenvolvimento sustentável regional ? » reponame:Repositório Institucional da UFC, 2012. http://www.repositorio.ufc.br/handle/riufc/16404.
Texte intégralRésumé :
ADERALDO, Janaína Ferreira. Complexo industrial e portuário do Pecém: promoção ou ameaça ao desenvolvimento sustentável regional?. Fortaleza – CE, 2012. xix, 151 f. : Dissertação (mestrado) - Universidade Federal do Ceará, Pró-Reitoria de Pesquisa e Pós –Graduação, PRODEMA - Programa de Pós-Graduação em Desenvolvimento e Meio Ambiente, Fortaleza-CE, 2012.Submitted by Eric Santiago (erichhcl@gmail.com) on 2016-04-20T12:29:55Z No. of bitstreams: 1 2012_dis_jfaderaldo.pdf: 5164310 bytes, checksum: 5e356c246f1d0a6d8b5e4177a1b2f5e8 (MD5)
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The growing shortage of natural resources and a greater occurrence of environmental disasters heat up the debate about the importance of previously analysing the consequences of the anthropic pressure made and critically reevaluate the relation between society and its natural and artificial environment in this historical setting, in which the concept of sustainable development takes shape and importance. Even though it is acknowledged the importance of indicators to measure the sustainable development, it is hard to believe that there will be some formula of wide acceptation due the existence of serious operational and conceptual rifts and blocks. Among the governmental programs that aim to correct distortions in all dimensions, it was elaborated, in Ceará, the plan of sustainable development – PSD of the state government. This plan incorporated the notion of sustainability in its development plans since 1995 and presented as goal the improvement of the quality of life of the population in period of time of 25 years, raising expectations of reduction of social inequalities. One of the goals in the Cearense government PSD is the implementation of the Pecém Industrial Port Complex – CIPP, a structutural state project that has the objective to make the operation of integrated industrial and portuary activities possible, paramount to the development. In the light of the above, the questioning to the developmental model proposed by the government came up, which discourse defines the model as sustainable. This is study aims to analyze how the developmental model proposed and financed by the government of the municipality of São Gonçalo do Amarante encourages the so called sustainable development. It has been observed that the investment attraction policy has placed a high priority on the service and industrial sectors, among other initiatives, which also promoted serious social (rural exodus, homelessness, lack of basic sanitation.) and environmental (defloration, loss of biodiversity, damage to water resources) problems. In addition, it has intensified even more the inequalities between the urban and rural regions for having diminished the prospects for employment in the countryside. It is suggested the adoption of possible corrective measures, as the planning of urbanization, good professional training for the local population, implementation of measures that encourage cultural and economical practices with dynamic nature, adoption of clean technology in all areas of operation, such as engineering, architecture, transportation, etc.
A crescente escassez de recursos naturais e maior ocorrência de desastres ambientais fomentaram o debate acerca da importância de analisar previamente as consequências da pressão antrópica exercida e, neste cenário histórico ganhou forma e valia o conceito de desenvolvimento sustentável, que provém da reavaliação crítica da relação existente entre a sociedade e seu meio natural e artificial. Mesmo sendo unânime o reconhecimento da importância dos indicadores para mensurar o desenvolvimento sustentável, é difícil acreditar que haverá alguma fórmula de ampla aceitação, devido à existência de sérias clivagens e bloqueios, tanto conceituais quanto operacionais. Dentre os programas governamentais que visam corrigir as distorções em todas as dimensões, foi elaborado no Ceará o Plano de Desenvolvimento Sustentável – PDS do governo estadual, que incorporou a noção sustentabilidade em seus planos de desenvolvimento a partir de 1995. Esse plano apresentou como objetivo a melhoria na qualidade de vida da população no espaço temporal de 25 anos e gerou expectativas de redução das desigualdades sociais. Uma das metas presentes no PDS do governo cearense foi a implantação do Complexo Industrial e Portuário do Pecém – CIPP, projeto estadual estruturante que tem como objetivo viabilizar a operação de atividades portuárias e industriais integradas, imprescindíveis ao desenvolvimento. Dado o exposto, surgiu o questionamento do modelo de desenvolvimento pretendido pelo Poder Público, cujo discurso define como sustentável, pois este estudo buscou avaliar de que forma o modelo de desenvolvimento proposto e financiado pelo governo no município de São Gonçalo do Amarante estimula o desenvolvimento. Observou-se que a política de atração de investimentos priorizou os setores industrial e de serviços, dentre outras iniciativas, que promoveram, também, sérios problemas sociais (êxodo rural, falta de moradia nas cidades, falta de saneamento básico) e ambientais (desmatamento, perda da biodiversidade, comprometimento dos recursos hídricos) além de intensificar ainda mais as desigualdades entre as regiões urbana e rural ao diminuir as perspectivas de emprego no campo. Sugere-se a adoção de medidas corretivas possíveis, como o ordenamento da urbanização, capacitação profissional de qualidade para população local, implantação de medidas fomentadoras de práticas culturais e econômicas de caráter dinâmico, adoção de tecnologia limpa em todas as áreas de atuação como engenharia, arquitetura, transporte, etc.
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Silva, Maria Aparecida da. « Caracterização histopatológica e imunoistoquímica de bexigas de bovinos com hematúra enzoótica ». Universidade Federal do Espírito Santo, 2012. http://repositorio.ufes.br/handle/10/5863.
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Previous issue date: 2012-02-27Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
Bovine enzootic hematuria (BEH) is caused by chronic ingestion of Pteridium aquilinum and is characterized by the presence of blood in the urine and development of lesions in the urinary bladder and is responsible for economic losses. Poisoning by this plant can also occur in humans. The objective was to evaluate the lesions in bladders of animals with BEH in the south region of the Espírito Santo. For this, were evaluated 350 bladders of bovines in a slaughterhouse and, of these, selected 46 that had macroscopic lesions and/or hematuria. Samples of each bladder were fixed in formalin 10% submitted to histological processing and classified by histomorphology. The immunohistochemistry was performed with anti-vimentin, anti-cytokeratin, anti-CD31, anti-VEGF and anti-uroplakin only in the 26 bladders that presented neoplastic lesions. Non-neoplastic lesions were observed in 100% of samples and the neoplastic in 56.52%. The presence of tumors was significant (p<0.05) in the caudal portion of the bladder. Detected neoplastic types were urothelial carcinoma, in situ carcinoma, adenocarcinoma, hemangioma, myxoma and hemangiosarcoma. There was a higher frequency of dysplasia, clear cell metaplasia, inflammation and vascular thickening in bladders with neoplasm. The expression of cytokeratin was significant (p<0.05) in epithelial neoplasms and vimentin in mesenchymal neoplasms. Uroplakin III differed in varied types of neoplastic lesions and showed to be typical and atypical while that of CD31 was significantly (p <0.05) in vascular mesenchymal neoplasms. A significant difference (p <0.05) in the number of vessels extratumorais stained by VEGF between myxomas and adenocarcinomas, and in intratumoral vessels stained by CD31 and VEGF in the different tumor types. Positive correlation existed between the number of intra- and extratumoral vessels in hemangiomas, hemangiosarcomas, and myxomas stained by CD31; between hemangiomas, myxomas, and adenocarcinomas stained with VEGF; between the expression of vimentin and CD31 and between cytokeratin and uroplakin. It is concluded that bladders from bovines with BEH have non-neoplastic and neoplastic lesions, isolated or associated. Biomarkers aid in the differentiation of the histogenesis of epithelial and vascular mesenchymal neoplasms. Uroplakin demonstrated to be effective for the assessment of integrity urothelial, and vascular markers (CD31 and VEGF) for endothelial integrity and for prognosis
A hematúria enzoótica bovina (HEB) é causada pela ingestão crônica de Pteridium aquilinum e caracteriza-se pela presença de sangue na urina e desenvolvimento de lesões na bexiga, sendo responsável por grandes perdas econômicas. A intoxicação por esta planta também pode ocorrer em humanos. Objetivou-se avaliar lesões de bexigas de animais com HEB na região sul do Espírito Santo. Para isto, foram avaliadas 350 bexigas de bovinos em matadouro frigorífico e, destas, selecionadas 46 que apresentavam lesões macroscópicas e/ou hematúria. Amostras de cada bexiga foram fixadas em formol a 10% submetidas ao processamento histológico de rotina e classificadas histomorfologicamente. A imunoistoquímica foi realizada com anti-vimentina, anti-citoqueratina, anti-CD31, anti-VEGF e anti-uroplaquina apenas nas 26 bexigas que revelaram neoplasia. Lesões não neoplásicas foram observadas em 100% das amostras e neoplásicas em 56,52%. A presença de neoplasias foi significativa (p<0,05) na porção caudal da bexiga. As neoplasias encontradas foram carcinoma urotelial; carcinoma in situ, adenocarcinoma, hemangioma, mixoma e hemangiossarcoma. Houve maior frequência de displasia, metaplasia de células claras, inflamação e espessamento vascular em bexigas com neoplasia. A expressão de citoqueratina foi significativa (p<0,05) nas neoplasias epiteliais e vimentina nas mesenquimais. A marcação da uroplaquina III diferiu nos diversos tipos neoplásicos e revelou-se típica e atípica enquanto que a do CD31 foi significativa (p<0,05) nas neoplasias mesenquimais vasculares. Houve diferença significativa (p<0,05) na quantidade de vasos extratumorais marcados pelo VEGF entre os mixomas e adenocarcinomas e nos vasos intratumorais marcados por CD31 e VEGF nos diferentes tipos tumorais. Houve correlação positiva entre os vasos extra e intratumorais nos hemangiomas, hemangiossarcomas e mixomas marcados pelo CD31; nos hemangiomas, mixomas e adenocarcinomas marcados pelo VEGF; entre a expressão de vimentina e CD31 e entre citoqueratina e uroplaquina. Conclui-se que bexigas de bovinos com HEB apresentam lesões não neoplásicas e neoplásicas, isoladas ou associadas. Os biomarcadores auxiliam na diferenciação da histogênese das neoplasias epiteliais e mesenquimais vasculares. Uroplaquina demonstrou-se efetiva para a avaliação da integridade urotelial e os marcadores vasculares (CD31 e VEGF) para a integridade endotelial e para o prognóstico
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Vegrichtová, Štěpánka. « Finanční analýza společnosti BVD PECE spol. s r.o ». Master's thesis, Vysoká škola ekonomická v Praze, 2007. http://www.nusl.cz/ntk/nusl-2172.
Texte intégralRésumé :
Diplomová práce je rozdělena na dvě části - teoretickou a praktickou. V teoretické části jsou shrnuty základní medoty, cíle a smysl finanční analýzy. V praktické části jsou pak metody aplikovány na konkrétní data společnosti BVD PECE spol. s r.o. Finanční zdraví firmy je hodnoceno za období 2002 až 2006. Praktická část je zaměřena zejména na horizontální a vertikální analýzu rozvahy a výsledovky, analýzu poměrových ukazatelů a interpretaci souhrnných testů - Kralickova quicktestu a indikátoru bonity.
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Bednár, Anton. « Využití bezdrátového měření teploty pro řízení rotační pece ». Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2013. http://www.nusl.cz/ntk/nusl-230894.
Texte intégralRésumé :
This project tries to find out the possible solution for temperature measurement and control on the rotary calcinations kiln at PRECHEZA company, by using of new wirelessHART temperature transmitters.
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Kolomazník, Milan. « Predikce koroze trubek pece s využitím provozních dat ». Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2014. http://www.nusl.cz/ntk/nusl-231497.
Texte intégralRésumé :
The thesis deals with the modeling and prediction of corrosion of radiation tube snake in the heating furnace. Specifically it is focused on vertical cylindrical furnace which is included in the catalytic hydrocracking unit and serves for heating aggressive circulation gas which is the cause of high temperature corrosion. An important basis for the creation of computational models are available records about the operation of the furnace and about the corrosion and degradation mechanisms during the lifetime of the tube system in furnace. Such information enables the creation of a computational model which is based on the prediction of high-temperature corrosive damage of radiation tube snake. The computational model involving all relevant factors may serve as the basis for a predictive life management system of radiation snakes in the heating furnace.