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Littérature scientifique sur le sujet « PDGR »

Auteur : Grafiati

Publié le 9 mars 2023

Mis à jour le 10 mars 2023

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Articles de revues sur le sujet "PDGR"

Das, Adrian J., et Nathan L. Stephenson. « Improving estimates of tree mortality probability using potential growth rate ». Canadian Journal of Forest Research 45, n^o 7 (juillet 2015) : 920–28. http://dx.doi.org/10.1139/cjfr-2014-0368.

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Tree growth rate is frequently used to estimate mortality probability. Yet, growth metrics can vary in form, and the justification for using one over another is rarely clear. We tested whether a growth index (GI) that scales the realized diameter growth rate against the potential diameter growth rate (PDGR) would give better estimates of mortality probability than other measures. We also tested whether PDGR, being a function of tree size, might better correlate with the baseline mortality probability than direct measurements of size such as diameter or basal area. Using a long-term dataset from the Sierra Nevada, California, U.S.A., as well as existing species-specific estimates of PDGR, we developed growth–mortality models for four common species. For three of the four species, models that included GI, PDGR, or a combination of GI and PDGR were substantially better than models without them. For the fourth species, the models including GI and PDGR performed roughly as well as a model that included only the diameter growth rate. Our results suggest that using PDGR can improve our ability to estimate tree survival probability. However, in the absence of PDGR estimates, the diameter growth rate was the best empirical predictor of mortality, in contrast to assumptions often made in the literature.

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Mikołajczyk, Jarosław, et Barbara Partyńska-Brzegowy. « Employment levels and costs of paid labour on agricultural commodity farms of the Visegrad Group countries ». Problemy Drobnych Gospodarstw Rolnych / Problems of Small Agricultural Holdings 1 (2015) : 19–28. http://dx.doi.org/10.15576/pdgr/2015.1.19.

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Molik, Edyta, et Michał Błasiak. « Alternative use types of sheep as a chance of survival for small farms in mountain and foothill areas ». Problemy Drobnych Gospodarstw Rolnych / Problems of Small Agricultural Holdings 1 (2015) : 29–41. http://dx.doi.org/10.15576/pdgr/2015.1.29.

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Musiał, Wiesław, et Tomasz Wojewodzic. « Theory of small land ownership in the scientific literature of the interwar period ». Problemy Drobnych Gospodarstw Rolnych / Problems of Small Agricultural Holdings 1 (2015) : 43–57. http://dx.doi.org/10.15576/pdgr/2015.1.43.

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Mickiewicz, Antoni, et Bartosz Mickiewicz. « Basic principles of direct payments implemented in the new financial perspective 2015–2020 ». Problemy Drobnych Gospodarstw Rolnych / Problems of Small Agricultural Holdings 1 (2015) : 5–17. http://dx.doi.org/10.15576/pdgr/2015.1.5.

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Szafrańska, Monika. « Determinants of the level of financial literacy among owners of small agricultural holdings in the Małopolskie Voivodeship ». Problemy Drobnych Gospodarstw Rolnych / Problems of Small Agricultural Holdings 1 (2015) : 59–72. http://dx.doi.org/10.15576/pdgr/2015.1.59.

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Wojewodzic, Tomasz, Magdalena Jezowit-Jurek et Piotr Rachwał. « Remuneration for labour on agricultural commodity farms in the Małopolska and Pogórze macroregion ». Problemy Drobnych Gospodarstw Rolnych / Problems of Small Agricultural Holdings 1 (2015) : 73–87. http://dx.doi.org/10.15576/pdgr/2015.1.73.

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Niedziółka, Arkadiusz. « The role of small farms in the development of agritourism services ». Problemy Drobnych Gospodarstw Rolnych Problems of Small Agricultural Holdings 2 (2015) : 17–36. http://dx.doi.org/10.15576/pdgr/2015.2.17.

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Pink, Małgorzata. « Poland as a wine country ? From traditions to emerging opportunities ». Problemy Drobnych Gospodarstw Rolnych Problems of Small Agricultural Holdings 2 (2015) : 37–56. http://dx.doi.org/10.15576/pdgr/2015.2.37.

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Czekaj, Marta. « Skills and training needs relating to the use of computers and the Internet among agricultural producers in the Małopolskie Voivodeship ». Problemy Drobnych Gospodarstw Rolnych Problems of Small Agricultural Holdings 2 (2015) : 5–16. http://dx.doi.org/10.15576/pdgr/2015.2.5.

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Thèses sur le sujet "PDGR"

BADIOLA, SANGA ALEXANDRA. « Study of the role of the SOX2 transcription factor in neural and mammary cancer stem cells using SOX2 conditional knock-out in mouse ». Doctoral thesis, Università degli Studi di Milano-Bicocca, 2014. http://hdl.handle.net/10281/52431.

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The stem cell-determining transcription factor Sox2 is required for the maintenance of normal stem cells. In this study, we investigated the requirement for Sox2 in neural and breast cancer stem-like cells. In the first case, using a conditional genetic deletion mutant in a mouse model of platelet-derived growth factor-induced malignant oligodendroglioma. Taken together, our results showed that Sox2 is essential for tumor initiation by mouse pHGG cells, and we illustrated a Sox2-directed strategy of immunotherapy to eradicate tumor-initiating cells. In the second case, we used a Sox2 conditional deletion by an MMTV-Cre transgene (active in mammary tissue) to address Sox2 requirement within a widely studied mouse model of mammary tumor, produced by expression of a transgene encoding a mutated ErbB2/Neu oncogene, driven to mammary tissue by the MMTV promoter. Our results point to a heterogeneity within mammary tumors regarding Sox2 expression and function, in particular within ErbB2/Neu-positive tumors, that it will be important to consider when hypothesizing therapy approaches.

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Eger, Glenda. « Regulation and Function of MAP Kinases in PDGF Signaling ». Doctoral thesis, Uppsala universitet, Ludwiginstitutet för cancerforskning, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-301057.

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Platelet-derived growth factor (PDGF) is a family of signaling molecules that stimulates cell growth, survival and migration. PDGF is recognized by specific transmembrane proteins, the PDGF receptors, which relay the signals to the cell activating the Mitogen-activated protein (MAP) kinases and other signaling pathways. Aberrant activation of these pathways is frequently detected in cancer. Hence, the study of these processes is essential for identifying potential drug targets or diagnostic markers. In paper I, we identified Receptor Subfamily 4 Group A Member 1 NR4A1 to be regulated by PDGF via MAP kinases, clarifying the role of Extracellular signal–regulated kinases (Erk) 1/2, Erk5 and Nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB) in its regulation. NR4A1 was found to be important for the tumorigenic potential, measured as anchorage-independent growth, of glioblastoma cells. Since the cellular responses elicited by PDGF result from the balance between phosphorylation and dephosphorylation events, we investigated the role of the dual specificity phosphatases DUSP4/MKP-2 and DUSP6/MKP-3. In paper II, we describe the crucial role of Erk1/2 and p53 in the expression of DUSP4/MKP2. Moreover, we observed that DUSP4/MKP-2 downregulation decreases Erk5 activation and accelerates PDGFRβ internalization and downregulation resulting in a specific inhibition of Signal transducers and activators of transcription (Stat) 3, Src and protein kinase C (PKC), and partially of p38, Stat1/5 and Phoshoplipase Cγ (PLCγ). In paper III, we report that DUSP6/MKP-3 creates a negative cross-talk between Erk1/2 and Erk5 and an auto-inhibitory feedback loop on the PI3-kinase/Akt pathway. In paper IV, we identify a new regulative mechanism of the PDGF pathway. PDGF induces Erk5 expression and activation that modulates the PDGFRβ activity. After Erk5 downregulation, the receptor undergoes to a faster and stronger activation that results in a faster internalization and degradation. In conclusion, we present a mechanism through which the PDGF/MAP kinases support tumor growth, and elucidate different regulatory pathways involved in PDGF signaling.

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Zhang, Xiao-Qun. « Functional Studies on the PDGFR α gene promoter and effects of autocrine PDGF-A stimulation in vivo ». Doctoral thesis, Uppsala universitet, Institutionen för genetik och patologi, 2001. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1455.

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Platelet-derived growth factor receptor α (PDGFRα) plays an important role during embryogenesis. After implantation, the patterns of expression of Pdgfrα and its ligand Pdgf-A undergo an "autocrine-paracrine transition", in that Pdgf-A becomes expressed in the ectoderm and epithelia, while Pdgfrα is expressed in the adjacent mesenchymal tissue. In human tumors, such as malignant glioma, both PDGF and PDGFRα are overexpressed within the same tissue, indicating that an autocrine PDGF loop is generated in the tumors. This thesis is focused on the in vivo functionality of the PDGFRα gene (PDGFRA) promoter, arid on the effect of autocrine PDGF-A stimulation in transgenic n-iice during embryogenesis. To test the in vivo promoter function of a human PDGFRA 2.2 kb 5' flanking fragment, we generated transgenic mouse lines and found that the 2.2 kb fragment was able to promote lacZ reporter gene expression in most of the endogenous Pdgfra expressing tissues. Absence of expression and "ectopic" expression of the transgenic lacZ were also observed. To investigate the autocrine PDGF effect, we produced autocrine PDGF-As (A short-chain) transient transgenic embryos. These transgenic embryos carried a 6 kb mouse Pdgfra 5' flanking sequence linked to a human PDGF-As cDNA. The pattern of expression of the PDGF-As transgene mRNA was similar to that of lacZ. Some of the transgenic embryos exhibited severe abnormal phenotypes, such as midline fusion defects in the cephalic and craniofacial region and small body size, and these embryos die at mid-gestation stage. These findings indicate that a paracrine pattern of expression and the dosage of PDGF are important for sustaining normal embryo development, especially with regard to the middline fusion in craniofacial regions. The possible signaling pathways that may be involved in regulating Pdgfra activity were also studied by comparison of patterns of mRNA expression of Gli, Ptc, and Paxl with that of Pdgfra. The results pointed to the possibility that the Shh signaling pathway may be involved in the regulation of Pdgfra expression for example during early bone and foregut development. The specific regulatory mechanisms may vary for different tissues.

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Ma, Haisha. « Regulation of Platelet-Derived Growth Factor Receptor Signaling and its Targeting in Cancer Therapy ». Doctoral thesis, Uppsala universitet, Ludwiginstitutet för cancerforskning, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-248172.

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Overactivity of platelet-derived growth factor receptor (PDGFR) is a frequent event in many types of solid tumors. Therefore, it is of great importance to uncover the mechanisms that regulate PDGF/PDGFR signalling, to develop efficient inhibitors targeting this pathway. The first step of downregulation of PDGFR activity upon ligand binding is internalization; thus we investigated how endocytosis pathways affect PDGFR signaling. We showed that in Ras-transformed fibroblasts, the internalization of PDGFR is shifted from the routine clathrin-dependent endocytosis to macropinocytosis, which results in enhanced PDGFR activity and subsequent downstream signalling, promoting anchorage-independent growth. We were also interested in how intracellular trafficking regulates signalling attenuation of PDGFR. We found that His-domain containing protein tyrosine phosphatase (HD-PTP) positively regulates phosphorylation level of the ubiquitin-ligases c-Cbl and Cbl-b; consistently, silencing of HD-PTP led to a decreased level of PDGFR ubiquitination (paper II). Consequently, internalized PDGFR could not be sorted properly and escaped degradation. This resulted in enhanced activation of phospholipase C γ (PLCγ) and changed kinetics of signal transducer and activator of transcription (STAT) 3 signalling, which further increased colony formation of HD-PTP silenced cells in soft agar, indicating a tumor suppressor role of HD-PTP. Activation of PDGFR leads to stimulation of downstream pathways. We identified Fer kinase as a critical signal transducer downstream of PDGFR in a proteomic screen. We showed that Fer kinase is essential for PDGF-induced STAT3 activation; as a result (paper III), Fer depletion severely blunted the ability of PDGFR signalling to promote anchorage-independent growth in soft agar and delayed tumor initiation in a mouse model. The crosstalk between host and tumor plays a critical role in tumor progression. At present most anti-cancer drugs are targeting tumor cells; we were interested in how targeting tumor host cells affects the efficacy of anti-tumor therapy. We found that selective PDGFRβ inhibition in host cells exerted tumor inhibitory effects on growth and vascularization of tumors with autocrine PDGF signaling, whereas tumors lacking such stimulation show only minor response on tumor growth (paper IV). Meanwhile, we demonstrated that PDGF/PDGFRβ signalling promotes expression of NG2, a marker for pericytes.

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Willetts, Karen Eve. « PDGF A and PDGF RÎ± in mammalian development ». Thesis, University of Oxford, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.318900.

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Hoflack, Bernard, Pierre Jurdic, Thilo Riedl, Anne Gallois et Maria Arantzazu Sanchez-Fernandez. « Osteoclasts control osteoblast chemotaxis via PDGF-BB/PDGF receptor beta signaling ». Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-184120.

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BACKGROUND: Bone remodeling relies on the tightly regulated interplay between bone forming osteoblasts and bone digesting osteoclasts. Several studies have now described the molecular mechanisms by which osteoblasts control osteoclastogenesis and bone degradation. It is currently unclear whether osteoclasts can influence bone rebuilding. METHODOLOGY/PRINCIPAL FINDINGS: Using in vitro cell systems, we show here that mature osteoclasts, but not their precursors, secrete chemotactic factors recognized by both mature osteoblasts and their precursors. Several growth factors whose expression is upregulated during osteoclastogenesis were identified by DNA microarrays as candidates mediating osteoblast chemotaxis. Our subsequent functional analyses demonstrate that mature osteoclasts, whose platelet-derived growth factor bb (PDGF-bb) expression is reduced by siRNAs, exhibit a reduced capability of attracting osteoblasts. Conversely, osteoblasts whose platelet-derived growth factor receptor beta (PDGFR-beta) expression is reduced by siRNAs exhibit a lower capability of responding to chemotactic factors secreted by osteoclasts. CONCLUSIONS/SIGNIFICANCE: We conclude that, in vitro mature osteoclasts control osteoblast chemotaxis via PDGF-bb/PDGFR-beta signaling. This may provide one key mechanism by which osteoclasts control bone formation in vivo.

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Hoflack, Bernard, Pierre Jurdic, Thilo Riedl, Anne Gallois et Maria Arantzazu Sanchez-Fernandez. « Osteoclasts control osteoblast chemotaxis via PDGF-BB/PDGF receptor beta signaling ». PLOS one, 2008. https://tud.qucosa.de/id/qucosa%3A28994.

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Pontén, Annica. « Biological activities of novel platelet-derived growth factors, PDGF-C and PDGF-D / ». Stockholm, 2004. http://diss.kib.ki.se/2004/91-7140-013-3/.

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Kowarik, Markus. « Expression, Lokalisation und funktionelle Bedeutung von PDGF und PDGF-Rezeptoren in der Hypophyse und in Hypophysentumorzellen ». Diss., lmu, 2007. http://nbn-resolving.de/urn:nbn:de:bvb:19-75767.

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Andræ, Johanna. « PDGF in cerebellar development and tumorigenesis ». Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2001. http://publications.uu.se/theses/91-554-4987-5/.

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Livres sur le sujet "PDGR"

Le PDG. Chicoutimi, Québec : Éditions JCL, 2000.

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Guinivan, Phyllis. Platelet-derived growth factor (PDGF). Bethesda, MD : U.S. Dept. of Health and Human Services, Public Health Service, National Institutes of Health, National Cancer Institute, International Cancer Research Data Bank, 1988.

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Company, Medical Economics. PDR medical dictionary. 2^e éd. Montvale, N.J : Medical Economics, 2000.

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George, Spratto, et Woods Adrienne L, dir. PDR nurse's handbook. 2^e éd. Montvale, N.J : Medical Economics, 1997.

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Marjory, Spraycar, et Medical Economics Company, dir. PDR medical dictionary. Montvale, N.J : Medical Economics, 1995.

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Elizabeth, Randolph, dir. PDR nurse's dictionary. Montvale, N.J : Medical Economics, 1994.

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Laos. Constitution of Lao PDR. Law on Government of Lao PDR. Law on Local Administration of Lao PDR. [Vientiane?] : Public Administration and Civil Service Authority, 2005.

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Company, Medical Economics, dir. PDR for nutritional supplements. Montvale, NJ : Medical Economics Co., 2001.

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Boudier, Jean-Pierre. De chômeur à PDG. Paris : Cherche midi, 2004.

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Sūn Khō̜mūn Khāosān Botbāt Ying-Sāi phư̄a Kānphatthanā., dir. Lao PDR gender profile. [Vientiane] : Gender Resource Information & Development Center, 2005.

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Chapitres de livres sur le sujet "PDGR"

Choi, Nahyun, Jung-Hun Moon et Jong-Hyuk Sung. « PDGF ». Dans Encyclopedia of Signaling Molecules, 3840–45. Cham : Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-67199-4_101813.

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Heldin, Carl-Henrik. « PDGF ». Dans Cancer Therapeutic Targets, 603–10. New York, NY : Springer New York, 2017. http://dx.doi.org/10.1007/978-1-4419-0717-2_16.

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Choi, Nahyun, Jung-Hun Moon et Jong-Hyuk Sung. « PDGF ». Dans Encyclopedia of Signaling Molecules, 1–6. New York, NY : Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4614-6438-9_101813-1.

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Heldin, Carl-Henrik. « PDGF ». Dans Cancer Therapeutic Targets, 1–8. New York, NY : Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4614-6613-0_16-3.

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Kuhn, Ferenc. « PDR ». Dans Vitreoretinal Surgery : Strategies and Tactics, 439–43. Cham : Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-19479-0_52.

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Hellberg, Carina, et Carl-Henrik Heldin. « Role of PDGF PDGF in Tumor-Stroma Interactions ». Dans Tumor-Associated Fibroblasts and their Matrix, 257–65. Dordrecht : Springer Netherlands, 2011. http://dx.doi.org/10.1007/978-94-007-0659-0_14.

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Kori, Mayuko, Natsuki Urabe, Shin-ya Katsumata, Kohei Suenaga et Ichiro Hasuo. « The Lattice-Theoretic Essence of Property Directed Reachability Analysis ». Dans Computer Aided Verification, 235–56. Cham : Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-031-13185-1_12.

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AbstractWe present LT-PDR, a lattice-theoretic generalization of Bradley’s property directed reachability analysis (PDR) algorithm. LT-PDR identifies the essence of PDR to be an ingenious combination of verification and refutation attempts based on the Knaster–Tarski and Kleene theorems. We introduce four concrete instances of LT-PDR, derive their implementation from a generic Haskell implementation of LT-PDR, and experimentally evaluate them. We also present a categorical structural theory that derives these instances.

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Hellberg, Carina, Arne Östman et C. H. Heldin. « PDGF and Vessel Maturation ». Dans Angiogenesis Inhibition, 103–14. Berlin, Heidelberg : Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-540-78281-0_7.

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Chitu, Violeta, Cristina I. Caescu, E. Richard Stanley, Johan Lennartsson, Lars Rönnstrand et Carl-Henrik Heldin. « The PDGFR Receptor Family ». Dans Receptor Tyrosine Kinases : Family and Subfamilies, 373–538. Cham : Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-11888-8_10.

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Pieters, B. R., et E. D. Geijsen. « Results of PDR Treatments : The AMC PDR Experience ». Dans Interstitial Prostate Brachytherapy, 203–6. Berlin, Heidelberg : Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-36499-0_17.

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Actes de conférences sur le sujet "PDGR"

Cherry, Michael S., Gregory M. Roach, Jonathan W. Wittwer, Larry L. Howell et Jordan J. Cox. « Reducing Cycle Time and Errors in the Design and Layout of MEMS ». Dans ASME 2003 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. ASMEDC, 2003. http://dx.doi.org/10.1115/detc2003/dac-48740.

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A design methodology is presented which decreases cycle time and opportunities for error through automated execution of a consistent design procedure. The Product Design Generator (PDG) methodology is useful for existing devices with a well-established design process. Two such examples are given, the Thermomechanical In-plane Microactuator (TIM) and the micro force gauge. In both PDGs, the designer inputs a finite set of requirements which automatically updates parametric design models. The necessary analyses are then executed, and product artifacts such as a CAD file, technical document, and test procedures are generated. The application of this method reduces the opportunities for error by ten times for the TIM PDG and five times for the micro force gauge PDG. The design cycle time is reduced from hours to minutes for both devices.

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Huang, Zhenjia (Jerry), et Yu Zhang. « Semi-Empirical Single Realization and Ensemble Crest Distributions of Long-Crest Nonlinear Waves ». Dans ASME 2018 37th International Conference on Ocean, Offshore and Arctic Engineering. American Society of Mechanical Engineers, 2018. http://dx.doi.org/10.1115/omae2018-78192.

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In wave basin model test of an offshore structure, waves that represent the given sea states have to be generated, qualified and accepted for the model test. We normally accept waves in wave calibration tests if the significant wave height, spectral peak period and spectrum match the specified target values. However, for model tests where the responses depend highly on the local wave motions (wave elevation and kinematics) such as wave impact on hull, green water impact on deck and air gap tests, additional qualification checks may be required. For instance, we may need to check wave crest probability distributions to avoid unrealistic wave crest in the test. To date, acceptance criteria of wave crest distribution calibration tests of large and steep waves of three-hour duration (full scale) have not been established. Two purposes of the work presented in the paper are: 1. to define and clarify the wave crest probability distribution of single realization (PDSR) and the probability distribution of wave crest for an ensemble of realizations (PDER) of a given sea state in order to use them appropriately; and 2. to develop semi-empirical probability distributions of nonlinear waves for both PDSR and PDER for easy, practical use. We found that in current practice ensemble and single realization distributions have the potential to be misinterpreted and misused. Clear understanding of the two kinds of distributions will help appropriate offshore design and production unit performance assessments. The semi-empirical formulas proposed in this paper were developed through regression analysis of crest distributions from a large number of sea states and realizations. Wave time series from potential flow simulations, computational fluid dynamics (CFD) simulations and model test results were used to establish the probability distributions. The nonlinear wave simulations were performed for three-hour duration assuming that they were long-crested. The sea states are assumed to be represented by JONSWAP spectrum, where a wide range of significant wave height, peak period, spectral peak parameter, and water depth were considered. Coefficients of the proposed semi-empirical probability distribution formulas, comparisons among crest distributions from numerical simulations and the semi-empirical formulas are presented in this paper.

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Najy, Abdo J., Allen Saliganan, Daniel Bonfil et Hyeong‐Reh C. Kim. « Abstract B10 : A novel mechanism of prostate cancer metastasis through the PDGF D/β‐PDGFR axis ». Dans Abstracts : First AACR International Conference on Frontiers in Basic Cancer Research--Oct 8–11, 2009 ; Boston MA. American Association for Cancer Research, 2009. http://dx.doi.org/10.1158/0008-5472.fbcr09-b10.

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Liu, Qing, Guanglin Wu, Kai Xu, Jack A. Roth et Lin Ji. « Abstract 706 : FUS1-mediated tumor suppression by inhibiting PDGF/ PDGFR signaling pathway in human lung cancer ». Dans Proceedings : AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010 ; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-706.

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Bryckaert, M. C., A. Wasteson, G. Tobelem, F. Rendu et J. P. Caen. « PLATELET DERIVED GROWTH FACTOR (PDGF) BINDS TO HUMAN PLATELETS AND MODULATES PLATELET ACTIVATION ». Dans XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643493.

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PDGF which is released during platelet activation like the other ∝ granule components (fibrinogen, F VIII/vWF, PF4) could bind to platelet membrane Following this hypothesis, we have studied the binding of 125I pure human PDGF to washed human platelets activated by collagen. This binding was specific and time dependent and reached a plateau with 20 μg/ml of collagen. With 200 fold excess of unlabeled PDGF, the binding of 125I-PDGF decreased progressively to 10 .whereas unlabeled Epidermal Growth Factor did not compete with 125I-PDGF. Saturation curve and scatchard analysis have shown one class of sites 3,000 sites/cell with an apparent Kd = 10-8 M. The demonstration of PDGF binding to platelets led us to investigate the effects of PDGF on platelet function. PDGF inhibited the aggregation and 14C serotonin release induced by thrombin or collagen. This inhibition was dose dependent and more effective with human PDGF. A total inhibition of collagen-induced platelet aggregation was obtained with 50 ng/ml of human PDGF and 200 ng/ml of porcine PDGF. The aggregation and 14C serotonin release induced by arachidonic acid were not inhibited by PDGF. The metabolism of phosphoinositide was also investigated on washed human platelets prelabeled with 32P orthophosphate. We found that PDGF (200 ng/ml) induced a decrease of 32P associated with phosphatidylinositol 4 biphosphate (72 %) after 3 min, with a parallel increase of 32P-phosphatidylinositol 4 Phosphate (120 %) and 32P-phosphatidylinositol (120 %).In conclusion i) PDGF binds to activated platelets, ii) PDGF inhibits platelet aggregation and secretion, iii) PDGF modifies phosphoinositide metabolism. These results are in favour of a role of PDGF in a negative feed back control of platelet activation.

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Sakaruassen, K. S., J. S. Powell, E. W. Raines et R. Ross. « SELECTIVE EXPRESSION OF PLATELET-DERIVED GROWTH FACTOR B-CHAIN mRNA BY HUMAN ENDOTHELIAL CELLS AND BY HUMAN PERIPHERAL BLOOD MONOCYTES, BUT NOT BY HUMAN SMOOTH MUSCLE CELLS ». Dans XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643752.

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Vascular injury may occur by a variety of mechanisms. Episodes of local hypoxia or conditions leading to local generation of thrombin may influence local cells to release growthregulatory molecules such as platelet-derivedgrowth factor (PDGF) in the surrounding connective tissue. The roles of the cells and of PDGF in these processes are not entirely understood, and this prompted us to investigate effects of hypoxia (5% O2) on cultured human saphenous vein endothelial cells andhuman thoracic aorta smooth muscle cells. Freshly isolated human peripheral blood monocytes were exposed to 3.0 U/ml a-thrombin. PDGF-A and PDGF-B mRNAs were analyzed by Northern blots, and their levels were assessed by dot blots utilizing 32P nick-translated cDNA probes. Selective expressionof PDGF-B mRNA occurred in endothelial cells during hypoxia and in monocytes exposed to thrombin. Genes coding for PDGF-A and PDGF-B are expressed cons tit utively, in endothelium, and after 48 hr of hypoxia a nine-fold increase of PDGF-B mRNA is detected (9 pg mRNA/ug total RNA). No detectable levels of mRNA encoding PDGF-A and PDGF-B were observed in freshly isolated monocytes; however, a 4-hr exposure to a-thrombin resulted in a selective and transitory increase in PDGF-B mRNA, amountingto 1 pg mRNA/ug toted RNA. No PDGF-B mRNA wasdetected after 20 hr. Hypoxic conditions did not trigger any selective expression of PDGF-B mRNA in smooth muscle, including arterialsmooth muscle derived from 1-day- and 3-month-old individuals, or from adult venous smoot muscle. However, constitutive expression of PDGF-A mRNA was observed in each of these, amounting to 0.4 pg mRNA/ug total RNA in the 1-day- and 3-month-old cells, and 0.2 pg mRNA/ugtotal RNA in the venous smooth muscle. Our datashow that endothelium and monocytes selectively express PDGF-B mRNA in vitro in response to conditions mimicking those encountered during vascular injury in some in-vivo situation.The data imply that both endothelial cells and monocyte/macrophages may be sources for mitogens that induce intimal hyperplasia and eventually plaque formation.

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Huber, L., C. Aderhold, N. Rotter et B. Kramer. « Die Auswirkung von Tyrosinkinaseinhibitoren auf die PDGF-AA/BB und PDGFR-α/β-Expression in HPV-positiven und –negativen Plattenepithelkarzinomzellen ». Dans Abstract- und Posterband – 91. Jahresversammlung der Deutschen Gesellschaft für HNO-Heilkunde, Kopf- und Hals-Chirurgie e.V., Bonn – Welche Qualität macht den Unterschied. © Georg Thieme Verlag KG, 2020. http://dx.doi.org/10.1055/s-0040-1711599.

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Hosoi, Fumihito, Hiromi Yokoi, Daisuke Nameki, Hiroaki Hayashi, Kenjiro Ito, Norio Masuko, Kazuhisa Minamiguchi, Ken-ichi Matsuo et Teruhiro Utsugi. « Abstract B1 : Antitumor activity of TSU-68 in PDGF-BB overexpressing U-87MG xenograft model : contribution of PDGFR blocking action. » Dans Abstracts : AACR-NCI-EORTC International Conference : Molecular Targets and Cancer Therapeutics--Nov 12-16, 2011 ; San Francisco, CA. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/1535-7163.targ-11-b1.

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Chang Li Si, Claire, Kwang Chian Chiew, Kit Teng Chaw, Raja Zuhaili Aimran Raja Zainal Raffik et Ryan Scott Guillory. « Multilayered Water Injection Zonal Allocation Without Intervention : Maximizing Value of a Smart Well by Harnessing Historical Data in Efforts to Expurgate Imprecise Injection Allocation ». Dans SPE Asia Pacific Oil & Gas Conference and Exhibition. SPE, 2022. http://dx.doi.org/10.2118/210752-ms.

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Abstract Field A begun water injection in 2016 via four water injector smart wells, which were equipped with Permanent Downhole Gauges and Inflow Control Valves. The water injection module was housed on a rented MOPU due to space limitation. Amidst the study to revamp the reservoir management plan, the team found multiple discrepancies in the reservoir zonal allocation dating back to start of injection. Inherently, this affects the Voidage Replacement Ratio tracking. Hence, the question remains: How efficient is the water injection in Field A? As Field A injects from a rented facility, the long term RMP strongly influences annual OPEX. This paper explains the journey of reallocating Field A water injection volumes from 2016 until today, and how it affects the outcome of the RMP study. PETRONAS has an offshore monitoring system which visualizes historical pressure and temperature trends at any tagged equipment. Field A water injectors consists of multi-zones completed with ICVs and PDGs. ICVs allow choking and zone changes to happen without intervention, and PDGs show downhole pressure and temperature changes over time. Coupled with the manual database which tracks ICV changes and water injection rates, the team re-modelled the injected volume allocation changes to each zone by anchoring the model on PDG trends, ICV size and choke coefficient, and water injection rates via an advance nodal analysis software. For reservoir characteristics calibration, properties from past FBUS interpreted results were used as a basis. From the modelling journey, at the same injection scheme, results showed that zonal allocation with small PDG pressure changes of less than 5% during stable injection conditions does not significantly affect allocation ratio in the well. Overall, the allocation would change between 0 - 3% in total. As one of the objectives of the exercise was also to gauge expected injected volume allocation to a specific zone when there were obvious pressure changes but no records of changing ICV sizes, this could be achieved via a calibrated model. Once a good anchor was made on reservoir pressure, formation gas-oil ratio, permeability and skin, devoid periods in the past could be modelled for expected ICV sizes by varying the choke size openings till the pressure differential between tubing and annulus pressure was achieved. Hence, modelling the expected zonal allocation during that period. This improved VRR tracking for the injection reservoirs and aided to in the efforts to revamp the reservoir management plan. This paper will explain the lessons learnt of having proper surveillance data as the impact on long term reservoir management plan is significant. In future, fields with smart wells but disorganized data can utilize this alternate method to reallocate production/injection volumes without the need for intervention.

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Bryckaert, M. C., A. Wasteson, M. Lindroth et G. C. Tobelem. « PLATELET DERIVED GROWTH FACTOR (PDGF) BINDS TO HUMAN BONE MARROW FIBROBLASTS AND STIMULATES THEIR PROLIFERATION. » Dans XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643494.

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A role for the Platelet Derived Growth Factor (PDGF) has been suggested in the abnormal proliferation of bone marrow fibroblasts occuring during myelofibrosis. To investigate this hypothesis, human bone marrow fibroblasts were isolated, and the cultures were characterized by immunofluorescent staining and electron microscopy. Electron microscopy eliminated the presence of endothelial cells by the absence of Weibel-Palade-Bodies. A positive intra and extra cellular antifibro-nectin staining was observed by immunofluorescent staining. The cultured cells didn’t show any labeling with specific antibodies for factor VIII von Willebrand factor, desmin or macrophage. Following the characterization of the bone marrow fibroblasts, using human pure 125I-PDGF, a specific binding of 125I-PDGF was demonstrated. The binding reached a plateau after 3 hours at 20°C, and after 4 hours at 4°C. Addition of unlabeled PDGF decreased this binding until 25 %.Saturation curve and scatchard analysis indicated two classes of sites with respectively 21,000 sites/aall and 37.000 sites/cell with an apparent Kd of 0.3 X 10-10 M and 0.5 X 10-9 M. Normal human serum at a concentration of 20 % induced a maximal DNA synthesis measured by-3H thymidine incorporation. When PDGF was added alone to the cultured fibroblasts at a concentration of 15 ng/ml, it induced a maximal DNA synthesis of 400 %.In the presence of 5 % of Platelet Poor Plasma (PPP), the same concentration of PDGF (15ng/ml) increased the incorporation of 3H thymidine up to 900%.In conclusion i) PDGF binds to human bone marrow fibroblasts, ii) PDGF stimulates their proliferation. These results are in favour of a role of PDGF in the proliferation of bone marrow fibroblasts associated with the development of myelofibrosis.

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Rapports d'organisations sur le sujet "PDGR"

Kumar, Avni, Jeremy Kohlitz et Juliet Willetts. Mainstreaming Climate Risks into Rural Sanitation Programming in Lao PDR. Institute of Development Studies, novembre 2022. http://dx.doi.org/10.19088/slh.2022.022.

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Despite climate change being a major concern for the sanitation sector, rural sanitation remains neglected in the wider discussions of climate impacts on WASH services. Also, the voices of vulnerable individuals, households, and communities who are experiencing the effects of climate change in relation to sanitation issues are missing. This learning brief presents learnings from a practitioner’s experience of integrating climate risk considerations into a Community-Led Total Sanitation (CLTS) programme. The interventions were piloted across three districts of Savannakhet province with a focus on villages that have frequently experienced heavy rainfall and flooding in the past. The learning brief is intended to provide inspiration and ideas to WASH experts and practitioners with interest in integrating considerations of climate change into rural sanitation programming.

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Pradesha, Angga. 2014 Social Accounting Matrix for Lao PDR : A Nexus Project SAM. Washington, DC : International Food Policy Research Institute, 2021. http://dx.doi.org/10.2499/p15738coll2.134910.

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Fatatis, Alessandro. Antibody-Mediated Targeting of Alpha PDGF Receptor to Inhibit the Progression of Skeletal Micro-Metastases. Fort Belvoir, VA : Defense Technical Information Center, octobre 2012. http://dx.doi.org/10.21236/ada570817.

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Sychareun, Vanphanom, Viengnakhone Vongxay, Souksamone Thongmixay et Jo Durham. Exposure to barbeque smoke in Vientiane, Lao PDR : Gendered disparities and unequal exposures for grillers. Stockholm Environment Institute, janvier 2023. http://dx.doi.org/10.51414/sei2023.001.

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The Faculty of Public Health at the University of Health Sciences, Lao PDR, in cooperation with SEI, conducted a research project, “Air pollution among grill workers in Lao PDR: Issues of inequalities and gender”. The team analysed the exposure of grill workers to PM2.5 and proposed risk reduction measures. Based on the research findings, this policy brief summarizes key issues related to unequal exposures to air pollution among grill workers in Vientiane, the capital of Lao PDR.

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Wentworth, A., P. Pavelic, S. Kongmany, T. Sotoukee, K. Sengphaxaiyalath, K. Phomkeona, P. Deevanhxay, V. Chounlamany et V. Manivong. Environmental risks from pesticide use : the case of commercial banana farming in northern Lao PDR. International Water Management Institute (IWMI), 2021. http://dx.doi.org/10.5337/2021.207.

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Nietschke, Yung, Anna Dabrowski, Maya Conway et Chaula Pradhika. COVID-19 Education Response Mapping Study : Building Resilience in Lao PDR : Readiness, Response, and Recovery. Australian Council for Educational Research, 2023. http://dx.doi.org/10.37517/978-1-74286-703-8.

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The coronavirus disease 2019 (COVID-19) crisis has caused unprecedented levels of disruption to education systems worldwide. Across the Asia region, it is estimated that around 760 million children were impacted by school closures at the height of the pandemic. Government response strategies have varied across the region, with some countries imposing prolonged school lockdowns while others have had short, repeated closure periods. As countries begin to reopen schools and continue to prepare for subsequent waves of COVID 19 infection, there is a need to develop the greater capability of education systems to safeguard learning and address persistent barriers to learning equality by harnessing the opportunities for systemic change. However, school-based practices and responses that have been effective in supporting the continuity of learning during the COVID-19 pandemic have yet to be well examined, particularly in Asia. This report presents the findings of a document review focused on the Lao People’s Democratic Republic (Lao PDR). This report forms part of a broader study that aims to explore the system and school-level practices that have supported learning continuity in Asia during the pandemic. The report will focus on the practices of policymakers that have the potential to support teaching and learning. Rather than comparing the responses of countries in Asia, this study will identify areas of opportunity and innovations in the system and school policies and programs in Lao PDR and make recommendations for those working to support Lao PDR’s education system.

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Sychareun, Vanphanom, Phonethipsavanh Nouanthong, Souksamone Thongmyxay, Chandavieng Phimmavong, Phouthong Phommavongsa, Vathsana Somphet, Jo Durham et Pauline Oosterhoff. Access to Covid-19 Vaccines and Concerns of Returnee Migrant Workers in Lao PDR During the Covid-19 Pandemic. Institute of Development Studies, juillet 2022. http://dx.doi.org/10.19088/ids.2022.048.

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In Lao PDR (Lao People’s Democratic Republic), out-migration, often to neighbouring Thailand, is an important livelihood pathway for workers. The Covid-19 pandemic, however, had a significant impact on these international migrant workers. As the pandemic evolved, and lockdowns and travel restrictions were implemented, thousands of the estimated 1.3 million Lao nationals living abroad, mostly in Thailand, found themselves unemployed and started returning to Lao PDR. Many of these returning migrants were infected or had been exposed to the Covid-19 virus, raising concerns of the potential for community transmission, especially with migrants returning to rural areas where health facilities are not always easily accessible and access to vaccines severely constrained. This research examined the access Lao international migrants returning to Lao PDR had to Covid-19 vaccination and the practical and ideological barriers returnee migrants faced in obtaining the vaccination.

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Redwine, Jeffrey M. The In Vivo PDGF Response During Remyelination in Mouse Spinal Cord Following Murine Hepatitis Virus Strain AS9-Induced Transient Demyelination. Fort Belvoir, VA : Defense Technical Information Center, août 1998. http://dx.doi.org/10.21236/ad1012058.

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Clement, C., J. Vinckevleugel, P. Pavelic, K. Xiong, L. Valee, T. Sotoukee, B. R. Shivakoti et K. Vongsathien. Community-managed groundwater irrigation on the Vientiane Plain of Lao PDR : planning, implementation and findings from a pilot trial. International Water Management Institute (IWMI), 2018. http://dx.doi.org/10.5337/2018.230.

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Hollingsworth, Hilary, Debbie Wong, Elizabeth Cassity, Prue Anderson et Jessica Thompson. Teacher Development Multi-Year Study Series. Evaluation of Australia’s investment in teacher development in Lao PDR : Interim report 1. Australian Council for Educational Research, 2022. http://dx.doi.org/10.37517/978-1-74286-674-1.

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The Government of Lao People’s Democratic Republic (Lao PDR) is undertaking significant primary education reforms, supported by the Australian Government's Department of Foreign Affairs and Trade (DFAT) through its flagship Basic Education Quality and Access in Laos program (BEQUAL). The Australian Government has commissioned a study to investigate how the BEQUAL program is making a difference to improving teaching quality and student learning outcomes. This research is part of a multi-year study series undertaken by DFAT's Education Analytics Service to investigate teacher and learning development initiatives in three countries: Lao PDR, Timor-Leste and Vanuatu. In 2019, the new curriculum for Lao language and other subjects was introduced for Grade 1 and is being phased in across all five primary grades. The new curriculum promotes teaching practices that support pedagogies focused on student-centred approaches, active learning, assessment of student learning progress, and a phonics approach to teaching reading. Teachers are being provided with teacher guides and other teaching and learning resources, and receive face-to-face orientation on the new curriculum. In BEQUAL-targeted districts, education support grants are also available to facilitate additional in-service support for teachers and principals. This study has provided the opportunity to investigate teaching quality and student literacy outcomes in Lao PDR over two rounds of data collection, with another planned for October 2022. The Baseline Report captured ‘state of play’ information in 2019 prior to major curriculum changes, as well as the onset of the COVID-19 pandemic. This summary provides an overview of findings and recommendations from the second year (2021) of the study, following two years of BEQUAL support for the implementation of the new Grade 1 Lao language curriculum.

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