Articles de revues : « Pathological Institute »

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Shah, Rushabh Jitendra, et Pradeep Vaideeswar. « Candidal endocarditis : a single institute pathological analysis ». Pathology 46 (2014) : S62. http://dx.doi.org/10.1097/01.pat.0000454313.47062.94.

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Vaideeswar, Pradeep. « Candidial Endocarditis : A Single-Institute Pathological Analysis ». Mycopathologia 180, n^o 1-2 (22 février 2015) : 81–87. http://dx.doi.org/10.1007/s11046-015-9876-3.

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Poppe, H., B. Dillinger et S. Lentner. « Pathological gambling and comorbidities ». European Psychiatry 26, S2 (mars 2011) : 92. http://dx.doi.org/10.1016/s0924-9338(11)71803-x.

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Pathological gambling accumulates frequently in connection with other diseases. This is documented both by studies and clinical observations, whereby no causalities can be derived, which underlying disease led to further diseases. Nevertheless different studies show similar results that pathological gambling arises increased in connection with substance dependence, depressive disorders, obsessive compulsive disorders and also personality disorders. These results stated in the literature also reflect the clinical observations of the Anton Proksch Institute.In the following presentation we will try to figure out the results of inpatients with the diagnosis pathological gambling, that were treated in the Anton Proksch Institute in the years 2008, 2009 and 2010. We find a range of comorbititys longing from substance abuse to personality disorders.

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Molochkova, Yulia V., et A. N. Khlebnikova. « Clinical and pathological red flat depriving association ». Russian Journal of Skin and Venereal Diseases 19, n^o 5 (15 octobre 2016) : 286–90. http://dx.doi.org/10.18821/1560-9588-2016-19-5-286-290.

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Knowledge of the morphological structure of atypicalforms of lichen planus is necessaryfor the correct diagnosis of lichen planus. Due to the large number of atypicalforms, diagnosis often requires a histological examination of the affected skin. The article describes pathological features of typical and some atypical forms of lichen planus, observed in recent years in the department of dermatology of Moscow Regional Research and Clinical Institute.

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Tcvetkova, M. M. « The formation and development of pediatrics and pediatric education in Primorye ». Pacific Medical Journal, n^o 4 (5 janvier 2022) : 5–9. http://dx.doi.org/10.34215/1609-1175-2021-4-5-9.

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The article presents historical information about the development of pediatrics and pediatric education in Primorsky Region. It started from the establishment of the pediatric faculty of the Vladivostok Medical Institute in 1969 to the present day. Main directions of scientific and pedagogical activities of pediatric profile departments are highlighted. The departments were reorganized in 2016 into the Institute of Pediatrics; departments of normal and pathological physiology, pathological anatomy, and foreign languages. The article also indicates those people who were at the origins of pediatrics and pediatric education in Primorye.

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Dobrynin, V. A. « 125 years of the Department of Pathological Anatomy at Kazan Medical Institute ». Kazan medical journal 70, n^o 2 (15 avril 1989) : 152–53. http://dx.doi.org/10.17816/kazmj99965.

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According to the June 18, 1863 University Charter, the fourth department of pathological anatomy in Russia (after Moscow, St.Petersburg and Derpt) was created at the Kazan University Medical Faculty. On October 21, 1863 A.V. Petrov (1837-1885) was appointed the first senior lecturer of the Department of Pathiatomy, who left his mark not only as an organizer of educational process, but also as a scientist and public figure. His studies on typhoid fever and uremia are classic. His experimental work, which showed the contagiousness of tuberculosis, anticipated the discovery of Mycobacterium tuberculosis by R. Koch. He gave much strength and energy to the Kazan Society of Physicians, of which he was the chairman for many years.

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Moussa, Sabri, et Wael H. El-Sheshtawy*. « Pathological Pattern of Urinary Bladder Cancer : Data from a Single Egyptian Institute ». Research in Oncology 13, n^o 1 (1 juin 2017) : 14–17. http://dx.doi.org/10.21608/resoncol.2017.869.1023.

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Chandrashekhar, Thotadamane Nagaraja, Anita Mahadevan, Santosh Vani, Thagadur Chickabasaviah Yasha, Somanna Sampath, Bangalore Anantaraman Chandramouli, Bhagavatula Indira Devi, Hanumantapura Ramalingaiah Arvinda et Susarla Krishna Shankar. « Pathological spectrum of neuronal/glioneuronal tumors from a tertiary referral neurological Institute ». Neuropathology 32, n^o 1 (17 mars 2011) : 1–12. http://dx.doi.org/10.1111/j.1440-1789.2011.01206.x.

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Chaudhari, Dr Bharat Muljibhai, et Dr Ashish N. Madiya. « Clinic Pathological Evaluation of Benign Breasts Lesion ». Tropical Journal of Pathology and Microbiology 7, n^o 1 (20 janvier 2021) : 40–43. http://dx.doi.org/10.17511/jopm.2021.i01.06.

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Introduction: Benign breast lesions are more common than malignant tumours. Hence recognizingthem is important from the viewpoints of therapy and prognosis. Methodology: The materials forthe study comprised of resected specimens of breast lesions received in the pathology departmentKarnataka Institute of Medical Sciences, Hubballi from May 2010 to April 2015. Results: A total of600 cases of benign breast lesions were recorded. Fibroadenoma was the commonest benign breastlesions comprising 70.82%, followed by fibrocystic disease 12%, benign phyllodes tumour 8.3%.The majority of benign breast lesions occurred in the 2nd decade and 3rd decade. Conclusion:Benign breast lesions were common. Conclusion: The most frequently encountered breast lesionswere fibroadenomas. So recognizing them is important for therapy and prognosis.

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Ravilov, R. Kh, et I. N. Nikitin. « PROFESSOR BOHL KARL GENRIKHOVICH - PATRIARCH OF VETERINARY SCIENCE AND EDUCATION (1871-1959) ». Scientific Notes Kazan Bauman State Academy of Veterinary Medicine 246, n^o 2 (1 juin 2021) : 177–81. http://dx.doi.org/10.31588/2413-4201-1883-246-2-177-181.

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The article describes the biography of Professor K. G. Bol, his scientific achievements, contribution to the development of the Kazan Veterinary Institute and the Department of Pathological Anatomy. His work is reflected in the Kazan State University, the Kazan State Institute of Advanced Training of Doctors, the Tatar Central Executive Committee, the Kazan City Council of People's Deputies.

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Ukrainets, Roman V., et Julia S. Korneva. « On the life of the defender of the fatherland and pathologist of professor Dmitry Pavlovich Svistelin ». Bulletin of the Russian Military Medical Academy 23, n^o 1 (12 mai 2021) : 243–46. http://dx.doi.org/10.17816/brmma63660.

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Svistelin Dmitry Pavlovich was born on November 27, 1923 in the town Seredina-Buda in the Ukrainian Soviet Socialist Republic. During the Great Patriotic War, he served in the 164th Tank Brigade of the 16th Tank Corps, which took part in the Battle of Kursk. In one of the battles, Dmitry Pavlovich was severely wounded, but after the Victory of the Soviet Union he found the strength and entered the medical faculty of the Lviv State Medical Institute and graduated form it in 1951. Subsequently, Dmitry Pavlovich came to Smolensk, where he became a postgraduate at the Department of Pathological Anatomy of the Smolensk State Medical Institute. From that moment he paid his debt to the Motherland already as a doctor being the head of the pathological department of the Smolensk Regional Psychiatric Hospital. Subsequently, Dmitry Pavlovich began to teach at the Department of Pathological Anatomy and became interested in scientific activities under the guidance of Professor Vladimir Gerasimovich Molotkov, who later guided him for both his candidates and doctoral dissertations. Having achieved a great success in the pathological anatomy and becoming a professor, Dmitry Pavlovich decided to return to practice again. In 1996, he shifted to the post of pathologist in the expert-organizational-advisory department of the Smolensk Regional Institute of Pathology, which even today bears his name due to his outstanding work both for pathological anatomy in general and for Smolensk medicine. For services to the Motherland both as a defender of the Fatherland and as a doctor, Dmitry Pavlovich Svistelin has such awards as the Order of the Patriotic War, 2nd degree, as well as the badge Excellence in Public Health. On June 16, 2006, at the age of 82, Professor Dmitry Pavlovich Svistelin passed away and was buried at the New Cemetery in Smolensk.

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Janković, Radmila, Emilija Manojlović-Gačić, Vladimir Kanjuh, Svetislav Tatić, Dimitrije Brašanac, Nada Tomanović, Sanja Radojević-Škodrić et Sofija Glumac. « History of the Institute of Pathology "Prof. dr Đorđe Joannović" : 100 years of experience and work ». Medicinska istrazivanja 57, n^o 2 (2024) : 103–11. http://dx.doi.org/10.5937/medi57-45370.

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One hundred years after its establishment, the Institute of Pathology "Prof. Dr. Đorđe Joannnović" remains the leading institution in Serbia and the region, where besides educating students and laboratory technicians, various state-of-the-art diagnostic procedures in the fields of histopathology, autopsy, and molecular pathology are conducted. The Department of General Pathology and Pathological Anatomy was also founded in 1922. Dr Đorđe Joannnović was the first full professor and the head of the department. After World War II, a joint department of four subjects was formed. An independent Department of Pathological Anatomy was reestablished in 1978, with academician Prof. Vladimir Kanjuh as the first head of the newly formed department. Teaching at the Department of Pathology has been conducted according to a new program since the academic year 2006/07 academic year. Since its beginings, the Department of Pathology has supported students' scientific research work and has been involved in facilitating professional and scientific international student exchange. Teaching of basic academic medical studies in English at the Department of Pathology has been ongoing since 1997. Within the department, there are specializations in Clinical Pathology and Medical Cytology, and in the academic year 2022/23 academic, the first generation of students in the "Pathological Basis of Diseases" doctoral program was enrolled. Today, the Institute of Pathology is listed among the reference institutions of the Republic of Serbia. It possesses a laboratory for routine histological processing of biopsy and autopsy material, an immunohistochemistry laboratory, and a laboratory for molecular pathology. Members of the Department and the Institute of Pathology are authors of numerous professional and scientific publications. They have been involved in founding and working within important professional, health, and scientific institutions in the country and the region. Owing to its exceptional contributions to the development of medical science and practice, the Institute of Pathology was awarded the Order of St. Sava, 3rd class, in 2017.

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Friend, G. G., T. B. Ponomareva et F. A. Shilova. « Military pages of history : department of pathological anatomy of Molotov medical institute during the Great Patriotic War of 1941–1945 – to the 75th anniversary of victory devoted* ». Perm Medical Journal 37, n^o 3 (16 septembre 2020) : 110–17. http://dx.doi.org/10.17816/pmj373110-117.

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The history of the Department of Pathological Anatomy of Molotov Medical Institute during the Great Patriotic War of 19411945 is presented. The working conditions of the department, the formation of pathological anatomy service in Perm and region, the active work of the department in training personnel for pathology departments, the creation of the society of pathologists, the scientific work of the department are shown.

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Rajković, Stanislav, Lazar Mičeta, Ljubica Simić, Goran Đuričić, Zoran Baščarević, Nenad Lujić et Jelena Sopta. « Skeletal metastases and pathological fractures of long bones ». Medicinska istrazivanja 55, n^o 3 (2022) : 7–12. http://dx.doi.org/10.5937/medi55-38372.

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Introduction. The most common cause of pathological fractures are skeletal metastases. Ten percent of patients with diagnosed skeletal metastases will sustain a pathological fracture. Skeletal metastases can be treated by non-surgical methods, including analgesics, bisphosphonates, and radiotherapy, with the primary goal of relieving pain and slowing down tumor growth. Surgical treatment is indicated for impending or existing fractures. It includes stabilization with internal fixation using various nails, plates, and screws with or without osteoplasty, and endoprosthetic joint replacement, especially in lesions around major joints - hip, knee, and shoulder. Material and Methods. The study included patients operatively treated at the Institute of orthopedics "Banjica" and pathohistologically analyzed at the Institute of pathology in Belgrade during the period from February 2021 to January 2022. Inclusion criteria were an existing or impending pathological fracture of long bones, operative treatment with tissue sampling, and the consequent pathohistological diagnosis of metastatic carcinoma. Patients with biopsy-proven processes other than metastatic carcinomas were excluded from the study. The total number of patients included in the study was 69. Results. The mean age of patients at the pathological fracture occurrence was 67.7 (ranging from 42 to 88). Malignant diseases diagnosed were: breast cancer 36.1%, lung cancer 24.5%, kidney cancer 14.5%, prostate cancer 13.1%, colorectal cancer 2.9%, other cancer (8.9%). The radiological presentation was in the form of lysis in 75.4% and in blastic form in 24.6%. Operative treatment included arthroplasty in 53.6% of patients and stabilization with nail or plate in 46.4%. Conclusion. Pathological fractures represent the final outcome of tumor activity in a bone and cause significant suffering in patients expressed through severe pain and often immobility, which accelerates all the pathological processes and leads to death. Joint methods of contemporary chemotherapy, radiotherapy, and surgery enabled a significant life quality improvement and extension in these patients.

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Sharma, Sourabh, Vikesh Kumar, Konark Thakkar et Yugam Prasad Shandilya. « A clinico-pathological study of minor salivary gland tumors : experience of our institute ». International Journal of Research in Medical Sciences 12, n^o 4 (29 mars 2024) : 1166–70. http://dx.doi.org/10.18203/2320-6012.ijrms20240838.

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Background: Minor salivary glands are found throughout the entire upper aerodigestive tract. Minor salivary gland neoplasms represent less than 25% of intraoral salivary neoplasms. There are no uniform guidelines at present for treatment for minor salivary gland tumors as these are rare entities. The objective of the study was to evaluate the clinicopathological profile of minor salivary gland tumors and to evaluate follow up of patients after treatment. Methods: The present study was a prospective observational study conducted on 11 patients of the Pacific Medical College and Hospital, Udaipur from 1 December 2020 to 31 December 2023 with complaints of intra-oral swelling with biopsy proven MSGT were included. Results: Out of 11 patients, 7 were female and 4 were male. Highest incidence was found in patients in the 4th-5th decade of life. For most patients, painless swelling was the primary presentation. The most common site for minor salivary cancer was the hard palate 55%. The most common histological types were adenocystic carcinoma. In 10 cases complete surgical excision with clear margins was the preferred mode of treatment. In 1 palliative therapy was required. Among 11 patients, 2 required radiotherapy. Conclusions: MSGT are rare, early diagnosed and resection with wide margins/neck dissections + SOS adjuvant therapy is key to treatment.

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Angelovski, Jani. « Thrombophilia in Pathological Pregnancies ». Macedonian Medical Review 70, n^o 3 (1 décembre 2016) : 129–32. http://dx.doi.org/10.1515/mmr-2016-0024.

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Abstract Introduction. Many situations in pregnancy create a thrombophilia, which is believed to have a protective function, which is the result of the hormone influence, primarily by gestagenic hormones. This is a physiological condition and it helps in successful implantation of the embryo and prevention of bleeding. The presence of additional, hereditary or acquired cause of thrombophilia disrupts the natural balance and creates conditions for venous thromboembolism and consequences for pregnancy, such as miscarriage, intrauterine fetal death, delayed intrauterine growth, eclampsia and abruption of the placenta. Methods. The study was designed as a retrospective epidemiological cross-sectional study and was conducted at the Institute of Transfusion Medicine in Skopje in the period from June to October 2016. The study included patients with current pathological pregnancies. The following laboratory analyses were conducted in all patients: hemostasis, D-dimer, antithrombin III, protein C, protein S, antiphospholipid antibodies, lupus anticoagulant, MTHFR, factor V Leiden and prothrombin mutation. Results. The study included 41 patients, of whom 3 were excluded due to an insufficient medical history, 3 who were receiving corticosteroid therapy, 2 due to incomplete laboratory analyses and one patient with proven systemic lupus. Data analysis showed that family history of thrombophilia was present in 25%. The most common MTHFR mutation was recorded in 26 (82%) patients, followed by the factor V mutation present in 18 (55%) of the examined patients. AT III deficiency was detected in only one patient (2%). In 12 patients (35%) a disturbed ratio of DD vs. markedly shortened APTT or inappropriately low levels of DD was registered, which is an indirect indicatorof hypofibrinolysis. Conclusion. Pathologic pregnancy is a condition that is often associated with thrombophilia. Advanced age of a patient, family and personal history of thrombotic conditions indicate a high risk of complications in pregnancy. Due to the current increased frequency of high risk pregnancies associated with circulation problems with the placenta, there is a need for more frequent hemostatic examinations in pregnancy.

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Savitskij, A. G., V. V. Abramchenko et G. A. Savitskij. « Pathological pre-conditions of complicated current of pregnancy at myoma uteri ». Journal of obstetrics and women's diseases 47, n^o 2 (15 août 1998) : 50–54. http://dx.doi.org/10.17816/jowd87248.

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Some results of work, executed in Scientific Research Institute of Obstetrics and Gynecology named after D.O.Ott of RAMS are submitted in the article. A regulation about pathological transformation of the myoma uterus was formulated. It was shown, that the changes in muscular, vascular and nervous systems of the uterus, normally developing and progressive in accordance with an increase of the tumours weight were pathological, biological inexpedient reaction of organ on occurrence into extraneous subject, which has dependence from hormones and possessing weight and scope. Pathological reactions, developed in myoma uteri are created the conditions for adverse current of pregnancy. Representations about morphological state of the uterus and the tumour during the pregnancy was detailed.

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Yeole, Ujwal, K. V. L. Narsinga Rao, Manish Beniwal, Sumitra Sivakoti, Vani Santosh et Sampath Somanna. « Cranial and Spinal Malignant Peripheral Nerve Sheath Tumor : A Pathological Enigma ». Journal of Neurosciences in Rural Practice 12, n^o 04 (28 septembre 2021) : 770–79. http://dx.doi.org/10.1055/s-0041-1735325.

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Abstract Objective Malignant peripheral nerve sheath tumor (MPNST) arises from nerve sheaths, mostly seen in peripheral nerves but rare in craniospinal nerves. The information available in the literature to build up treatment strategy and improve clinical outcomes is scarce. We are reviewing cases from our institute, with emphasis on radiological features for early differentiation from its benign variants. Methods We analyzed pathologically diagnosed cases retrospectively from January 2007 to December 2018 at our institute. Clinicoradiological details and treatment parameters were collected from medical records for evaluation. Each case was contacted telephonically for final clinical follow-up at the time of writing the manuscript. Results A total of seven cases of MPNST were diagnosed in the last 10 years. It included four intracranial and three spinal cases. The mean age for the cohort was 34.3 years, with five females. We could achieve gross total resection (GTR) and subtotal resection in four (57.1%) and two (28.6%) cases, respectively. We could achieve an overall survival of 57.1% in the average follow-up of 28.2 months (range: 8–84 months). Conclusion MPNST is a rare tumor with a bad prognosis. Radical surgical resection is the mainstay of the treatment, but it is not always possible to achieve it because of the inaccessible location and large size of lesions. Preoperative diagnosis is challenging; however, few radiological findings may give a clue toward it. As a disease entity overall, it has a poor outcome with a high rate of fatality.

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Tolpegina, T. B. « Professor Irek Makhmudovich Rakhmatullin ». Kazan medical journal 69, n^o 2 (15 avril 1988) : 152–53. http://dx.doi.org/10.17816/kazmj97271.

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In April 1988, Professor Irek Makhmudovich Rakhmatullin, honored scientist of TASSR, Head of the department of pathological physiology of Kazan Medical Institute named after S.V. Kurashov, Doctor of medical sciences, will be 60 years old and 38 years of his labor activity.

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Fallahi, F., A. Waton, M. Mansha, W. Cope, H. O’Brien et C. F. Young. « Bilateral pathological neck of femur fractures associated with low grade splenic marginal zone lymphoma : Case report, and review of the literature ». International Journal of Diagnostic Imaging 1, n^o 2 (20 avril 2014) : 47. http://dx.doi.org/10.5430/ijdi.v1n2p47.

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We report a case involving a 64 year old lady with bilateral pathological fractures of the neck of the femur secondary to Low Grade Splenic Marginal Zone Lymphoma, a pathology that has not previously been described in clinical literature. This particular case also highlights the value of the diagnosis and management of patients presenting with subtle and unusual symptoms, and supports the current guidance of the National Institute for Health and Care Excellence regarding the investigation of patients with suspected pathological neck of femur fracture.

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Nadi, Enas El, Hanafy Hafez, Alaa Younes, Gehad Ahmed, Mohamed S. Zaghloul, Hala Taha, Naglaa ELkinaai et al. « Survival and factors affecting the outcome of synovial sarcoma in children and adolescents single institute experience ». Journal of Solid Tumors 9, n^o 2 (14 avril 2019) : 6. http://dx.doi.org/10.5430/jst.v9n2p6.

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Introduction: To check the impact of the clinical and pathologic features at diagnosis and treatment given, on the outcome of synovial sarcoma in children and adolescents.Methods: Retrospective analysis of patients below 18 years old diagnosed by synovial sarcoma and treated at Children CancerHospital Egypt 57,357 (CCHE) between July 2007 and December 2016. We reviewed Clinical characteristics, pathological information, treatment modalities and survival data.Results: We included thirty one patients with median age at diagnosis was 14.8 years. Initial surgical excision was possible in 10 patients (58.8%) while 5 (29.4%) patients underwent surgical excision after response to preoperative chemotherapy. Two patients had unresectable tumor, showed no response to chemotherapy and received radiotherapy as the only local control therapy. Adjuvant radiotherapy only was given in 2 patients and 5 patients received chemotherapy without local radiotherapy and 10 patients received both modalities. The estimated 5-year overall survival and failure free survival rates for the entire group were 84.4% ± 7.2% and 63.8% ± 9.7% respectively, the 5-year OS and FFS were studied in correlation to age of patient, tumor size, different pathological types, site of the lesion and methods of local control. In patients with tumor size below 5 cm when compared to size more than 5 cm with OS was (100%) in comparison to (79.3 ± 9.3) who underwent complete surgical excision either initial or post chemotherapy as it was 66.7% versus 55.6% for those with gross or microscopic residual (p-value = .38). Also, the 3-year failure free survival was 75% versus 56.3% for those smaller than or equal 5 cm and those larger than 5 cmrespectively (p-value = .3).Conclusion: Increasing number of patients to increase sample size to assess tumor size and complete surgical excision as important prognostic factors as in our study, we found them statistically insignificant. Preoperative chemotherapy can help for delayed excision in patients presented initially with unresectable tumors

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Strashok, L. A., G. M. Danilenko, E. M. Zavelya, M. Y. Isakova et A. V. Yeshchenko. « About perspectives for the development of school medicine in Ukraine ». Shidnoevropejskij zurnal vnutrisnoi ta simejnoi medicini 2022, n^o 2 (2022) : 11–16. http://dx.doi.org/10.15407/internalmed2022.02.011.

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The article presents the history of the development of school medicine in Ukraine, the birth of national school hygiene as an independent science. It was emphasized that school medical services are very important both in maintaining the health of the younger generation and in providing the best conditions for its formation, health promotion, and prevention of pathological conditions. In 1922–1935, institutes of health care for children and adolescents and institutes for the protection of motherhood and childhood were opened in Ukraine for the scientific development of health care issues for schoolchildren and adolescents. In October 1922, the first Ukrainian State Institute for Maternal and Child Health was opened in Kharkiv, which is now called SI «Institute of Children and Adolescents Health Care of the National Academy of Medical Sciences of Ukraine». The Institute has become a leading research institution in Ukraine, which coordinates research on «Health Care of schoolchildren and adolescents», trains highly qualified personnel, publishes methodological and informational materials for implementation in practice, conducts scientific and practical conferences, and scientific symposiums on topical issues, including school medicine. According to the Resolution of the Cabinet of Ministers of Ukraine № 31 of January 20, 2021 «On approval of the Procedure for providing medical care to students of general secondary education» medical care for students is now provided by a medical worker who is a member of the educational institution. Ways to improve the organization of medical care for students in secondary schools for more effective development of school medicine, the expediency of using the resources of the SI «Institute of Children and Adolescents Health Care of the National Academy of Medical Sciences of Ukraine» are presented. Therefore, only the combined work of educational and health care institutions can provide the most favorable conditions for maintaining the health of students.

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Újhelyi, Mihály, Dávid Pukancsik, Péter Kelemen, Ákos Sávolt, Mária Gődény, Eszter Kovács, Nóra Udvarhelyi et al. « A European Society of Breast Cancer Specialists (EUSOMA) előírásainak megfelelő emlőrákellátás minőségbiztosítási elemzése az Országos Onkológiai Intézetben ». Orvosi Hetilap 157, n^o 42 (octobre 2016) : 1674–82. http://dx.doi.org/10.1556/650.2016.30555.

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Introduction: The European Society of Breast Cancer Specialists has created quality indicators for breast units to establish minimum standards and to ensure specialist multimodality care with the conscious aim of improving outcomes and decreasing breast cancer mortality. Aim: The aim of this study was to analyse the breast cancer care in the National Institute of Oncology according to the European Society of Breast Cancer Specialists requirements and in a large number of cases in order to present representative clinico-pathological data on the incidence of breast cancer in Hungary. Method: According to the European Society of Breast Cancer Specialists uniformed criteria clinico-pathological data of multimodality treated breast cancer cases were retrospectively analysed between June 1, 2011 and May 31, 2012. Results: During the period of interest 906 patients underwent breast surgery for malignant or benign lesions. According to the European Society of Breast Cancer Specialists quality indicators the breast cancer care of the National Institute of Oncology is eligible. Conclusions: The diagnostic modalities and multimodality care of breast cancer of the National Institute of Oncology breast unit meets the critical mass and minimum standards of the European Society of Breast Cancer Specialists criteria. Orv. Hetil., 2016, 157(42), 1674–1682.

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Reshetnikova, I. D., et P. D. Dunaev. « Academician Andrei Dmitrievich Ado and the Kazan Scientific Research Institute of Epidemiology and Microbiology ». Kazan medical journal 102, n^o 1 (10 février 2021) : 115–22. http://dx.doi.org/10.17816/kmj2021-115.

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The article was prepared for the 120th anniversary of the Kazan Scientific Research Institute of Epidemiology and Microbiology and the 110th anniversary of the birth of the academician, laureate of the USSR State Prize, the author of fundamental guidelines on allergology and pathological physiology, an honorary member of scientific societies of many countries Andrei Dmitrievich Ado who is a representative of the famous dynasty of scientists and doctors of Mislawski-Ado. The paper presents materials about the dynasty A.A. Mislavsky, N.A. Mislavsky, A.N. Mislavsky and others; information about the Kazan period of A.D. Ado between 1938 and 1952 during his work at Kazan Scientific Research Institute of Epidemiology and Microbiology (Kazan Institute of Epidemiology and Microbiology until 1942). The article was prepared using documents from the archives of Kazan Scientific Research Institute of Epidemiology, Microbiology, Kazan Medical University, memoirs of their colleagues.

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Redaelli, V., C. Calatozzolo, G. Marucci, V. Pinzi, P. Gaviani, A. Botturi, G. Simonetti, L. Mattei, B. Pollo et A. Silvani. « P11.68.A Hemangiopericytoma, case series and clinic-pathological analysis ». Neuro-Oncology 24, Supplement_2 (1 septembre 2022) : ii74. http://dx.doi.org/10.1093/neuonc/noac174.257.

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Abstract Background Hemangiopericytoma (HPC) is an extremely rare aggressive tumor of mesenchymal origin, which constitutes less than 1% of primary tumors of the central nervous system. Typically it occurs in young adults (mean age at diagnosis 30-50 years). Initially described as gemmangiomas, was first called hemangiopericytoma in 1942 but it was considered as a variant of meningioma until 1993 when it was finally recognized as a distinct clinical-pathological entity by the World Health Organization (WHO). In 2016, there was the unification of both HPC and Solitary Fibrous Tumor (SFT) in a single spectrum of rare and thick mesenchymal tumors due to the identification, in both tumoral types, of a molecular alteration called NAB2-STAT6 fusion. Material and Methods The present study is a case series of patients that received a pathological diagnosis of SFT/HPC at our Institute from 1981 to 2020. Clinical data included: demographic data, tumor characteristics and treatment modality. Hystological diagnosis and immunohistochemistry allowed to confirm diagnosis, based on the 2016 WHO classification. Haematoxylin staining was completed with immunohistochemistry with primary antibodies for STAT 6 and evaluation of presence of tumor necrosis. Statistical analysis was conducted considering age at first diagnosis, treatment modality, extent of tumor resection, presence of necrosis in histological analysis compared to PFS-1, OS and relapses number. Results The case series was composed by 82 patients (46 men and 36 women) with median age of 43 (± 20) that accede to our Institute from 1981 to 2020. Our statistical analysis showed significative correlation between age, extend of tumor resection and presence of necrosis with OS and relapses number. Conclusion Hemangiopericytoma is a very rare cerebral tumors, and for this reason large case series are not disposable in literature. In our study we collected all disposable data of every patient with pathological diagnosis of SFT/HPC acceded to our hospital in the long period of 39 years in the aim to verify the presence of significative correlations. We observed strong correlation between tumor resection and presence of necrosis in tumor tissue with prognosis parameters (OS and number of relapses). This result it could be important to conduct the decisional process about treatment after surgical resection, considering also pathological features, rather than only surgical resection.

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Ibrahim, E. A. « Survival of patients with locally advanced triple-negative breast cancer after neoadjuvant platinum-containing chemotherapy : Experience of a single institute. » Journal of Clinical Oncology 29, n^o 27_suppl (20 septembre 2011) : 274. http://dx.doi.org/10.1200/jco.2011.29.27_suppl.274.

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274 Background: Primary systemic chemotherapy is a standard approach to treating women with locally advanced breast cancers, with higher survival rates reported among patients who attain a pathologic complete response. Triple-negative breast cancer is a special biological entity that remains major challenge to oncologist. Around 12%-20% of breast cancers are triple negative. The current phase II study was conducted to evaluate the pathological complete response (pCR) using cis-platinum containing regimen as neoadjuvant chemotherapy in locally advanced triple negative breast cancer. Methods: Eighteen women with stage III triple negative breast cancer who were recruited between July 2007 and February 2010 at King Fahad Specialist Hospital, Dammam, Saudi Arabia. Neoadjuvant chemotherapy consisted of 4 cycles of AC or FEC 100, followed by 4 cycles consisted of docetaxel-cisplatin every 3 weeks. Primary end point was pathological complete response. Results: Median age: 49 y (24-70); premenopausal: 16; 25% were below 35 years of age; Median tumor size: 9 cm (3.5-19); Grade III: 15; Stage IIIA: 3, IIIB:14, IIIC:1; all but 2 had positive nodes at diagnosis (89%). Clinical evaluation of response by RECIST criteria pre surgery: OR: 17/18 (94%), CR: 9 (50%); PR: 8 (44%).The second sequence with D-Cis-T doubled the rate of clinical CR obtained with AC/FEC. One patient was not operated due to disease progression. Pathological assessment, revealed that 8 (47%) pts had no residual invasive carcinoma in the breast; 3 (18%) had residual occasional scattered tumor cells less than 5 mm (pT1a); 10 (59%) had negative nodes; 8 achieved CpR and 2 nCpR. Patients with residual invasive component and/or nodal involvement had high baseline Ki 67 level. After a median follow up of 24 months, cumulative overall survival at 24 months is 88.9% for whole group. Cumulative overall survival in relation to response was 100% for patients who achieved pCR while overall cumulative survival rate for patients without pCR was 83.3% without statistical significance. Conclusions: This cisplatin based neoadjuvant chemotherapy regimen was well tolerated and achieved a high rate of pCR/npCR.

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Luigetti, Marco, Angela Romano, Andrea Di Paolantonio, Giulia Bisogni, Salvatore Rossi, Amelia Conte, Francesca Madia et Mario Sabatelli. « Pathological Findings in Chronic Inflammatory Demyelinating Polyradiculoneuropathy : A Single-Center Experience ». Brain Sciences 10, n^o 6 (17 juin 2020) : 383. http://dx.doi.org/10.3390/brainsci10060383.

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Objective: Segmental demyelination is the pathological hallmark of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), but other elementary lesions are frequently observed, configuring a series of different pathological pictures. In this article, we review the pathological findings of a large series of sural nerve biopsies from our cohort of CIDP patients. Patients and Methods: Patients with CIDP who underwent nerve biopsy were retrospectively selected from those referred to the Institute of Neurology of the “Università Cattolica del Sacro Cuore” in Rome, Italy, from 1982 to February 2020. Sural nerve biopsy was performed according to standard protocols. Results: Sural nerve biopsy was performed in 43/130 CIDP patients. Demyelinating abnormalities and axonal loss were found in 67.4% and 83.7% of biopsies, respectively. Conversely, onion bulbs and inflammatory infiltrates were rare (18.6% and 4.7%, respectively). In three cases, we observed normal pathological findings. Conclusions: A pathognomonic pathological finding of CIDP cannot be established, but we confirm the utility of nerve biopsy in this setting to confirm the diagnosis (also in atypical phenotypes) and to elucidate pathogenic mechanisms.

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Pietrantonio, Filippo, Jorgelina Clara Coppa, Rosalba Miceli, Massimo Milione, Federica Perrone, Giuseppe Fanetti, Cotsoglou Christian et al. « High pathologic response rate of hepatic colorectal cancer metastases (HCRM) following neoadjuvant bevacizumab (Bev)-based treatment (tx). » Journal of Clinical Oncology 31, n^o 4_suppl (1 février 2013) : 529. http://dx.doi.org/10.1200/jco.2013.31.4_suppl.529.

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529 Background: Pathologic response of HCRM to neoadjuvant tx is associated to better outcome. In retrospective analyses Bev-based tx improved tumor regression grade (TRG), while cetuximab (Cmab) increased RECIST response and R0 resections in prospective studies. The aim of this analysis was to assess the effect of Bev vs Cmab-based tx in terms of HCRM pathological response and outcome. Methods: Fifty-eight pts with HCRM were resected at National cancer Institute of Milan from 2007 to 2012 following Bev (n=30) or Cmab (n=28) based neoadjuvant tx. Pathological response was classified from TRG 1 for pathological complete response (pCR), to TRG5 for no response; TRG 1-3, for histological response; TRG 4-5 for scarce/no response (Rubbia-Brandt L, Ann Oncol 2007). Results: KRAS missing in 9 pts (3 Bev/6 Cmab), mutated in 18 pts (60%) in Bev vs 4 (14%) in Cmab group.Median number of resected metastases: 4.6 vs 3.9; mean TRG: 2.9 (2.2-4) in Bev vs 3.8 (3-5) in Cmab group (p=0.04 at Kruskal-Wallis test). Pathological response rate was higher for Bev vs Cmab (70% vs 39%; p=0.037 at Chi-square test). Bev also increased pCRs (20% vs 0%, p=0.024 at Fisher’s test). With generalized estimating equation for all resected nodules, mean TRG was lower in Bev vs Cmab group: 2.6 (2-4) vs 3.7 (3-4), p<0.001. At univariate analysis, no PFS and OS difference was observed according to tx. Multivariable Cox models shown below: Conclusions: Bev-based tx obtained an excellent pathological response rate, despite the high proportion of KRAS mutated tumors, and further prospective confirmation of these data is planned. [Table: see text]

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Babirad, A. M. « ATTITUDES TOWARDS DISEASE IN PATIENTS WITH CHRONIC PHASE OF ISCHEMIC STROKE BY THE RESULTS OF THE PERSONAL QUESTIONNAIRE OF THE BEKHTEREV INSTITUTE ». East European Journal of Parkinson`s Disease and Movement Disorders 6, n^o 3-4 (30 décembre 2020) : 19–26. http://dx.doi.org/10.33444/2414-0007.6.3-4.19-26.

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Every year, strokes are diagnosed in about 16 million people, of whom 5.7 million die and about the same number become disabled (Feigin V.L., Forouzanfar M.H., Krishnamurthi R., et al., 2014; Virani S.S., Alonso A., Benjamin E.J., et al., 2020; Kim J., Thayabaranathan T., Donnan G.A., et al. 2020). The objective of our research was to study the attitudes towards disease in patients with chronic phase of ischemic stroke. Material and methods. 100 consecutive patients with chronic phase of ischemic stroke and 17 patients with chronic cerebral ischemia were questioned in neurology in-patient department. The types of attitude towards disease were identified with the help of the Personal Questionnaire of the Bekhterev Institute. Results. We found that pathological types of attitude towards disease begin to form before the development of a stroke as a result of chronic cerebral ischemia. Among patients with chronic phase of ischemic stroke, pathological types of attitude towards disease prevailed significantly, and the harmonious type was rare (84.0% vs 16.0%, p < 0.001). The most frequently observed were neurasthenic (36.0%), harmonious (16.0%), anxious (16.0%), ergopathic (10.0%) and sensitive (8.0%) types of attitude towards disease. Our study has shown that any ischemic stroke, even in the case of complete recovery of the lost functions, can be associated with pathological types of attitude towards disease. Keywords: ischemic stroke, the Personal Questionnaire of the Bekhterev Institute, attitudes towards disease.

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Uprety, A., N. Bhatta, R. Shahi, A. Varma, Y. Dhakal, P. Aryal, D. K. Yadav, S. Chaudhary, S. Hamal et D. R. Mishra. « Pulmonary Alveolar Proteinosis : Conducting the first Whole Lung Lavage in Nepal ». Nepalese Respiratory Journal 2, n^o 1 (6 novembre 2023) : 34–37. http://dx.doi.org/10.3126/nrj.v2i1.59616.

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A case of Pulmonary Alveolar Proteinosis, probably secondary in etiology, was diagnosed at our institute based on clinical, radiological, and pathological evidence. Patient was planned for conducting whole lung lavage as per the guidelines. With this case, we report the first instance of conducting Whole lung lavage in Nepal and the logistics involved.

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Ramadan, Mostafa, et Rabie Ramadan. « Clinical Significance of Pathological Nipple Discharge as a Single Breast Symptom : A Single-institute Experience ». Acta Scientific Women's Health 2, n^o 12 (28 novembre 2020) : 34–40. http://dx.doi.org/10.31080/aswh.2020.02.0165.

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Zubritsky, Alexander. « About the pathologist-morphometrist Georgy Gerasimovich Avtandilov ». Vestnik of Saint Petersburg University. Medicine 17, n^o 1 (2022) : 53–62. http://dx.doi.org/10.21638/spbu11.2022.106.

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The article shows the life and creative path of Georgy Gerasimovich Avtandilov, the outstanding domestic pathologist-morphometrist, who for the first time created the Soviet school of quantitative pathological anatomy. A Doctor of Medical Sciences, Professor, Academician of the Russian Academy of Natural Sciences, Honored Doctor of Kabardino-Balkaria, Honored Scientist of the RSFSR and the Republic of North Ossetia-Alania, Avtandilov was born in the town of Kizlyar. After graduating from high school, he entered the Novocherkassk Industrial Institute, but in his second year of studies he was called up to serve in the Workers-Peasant Red Army in the town on the Bialystok ledge of the border, where in 1941 he was captured and held in the Lamsdorf concentration camp almost until the end of the war, having gone through a living hell. After the end of the war and the end of the North Ossetian Medical Institute, the fate of G. G. Avtandilov developed in such a way that the choice was made for life in favor of pathological anatomy.

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Starčević, Darko, Ljubica Simić, Goran Đuričić, Stanislav Rajković et Jelena Sopta. « Clinical pathological characteristics of pelvic bone tumors ». Medicinski podmladak 72, n^o 4 (2021) : 20–26. http://dx.doi.org/10.5937/mp72-33519.

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Introduction: Bone tumors are rare neoplasms whose therapy depends on the location. Pelvic bones represent a special anatomical entity diagnosis and therapy of pelvic tumors in addition to the pathohistological type largely depends on the anatomical specifics of that region. Aim: The aim of this study was to show the frequency, as well as clinical and pathological characteristics of primary and secondary tumors of the pelvic bones. Material and methods: The research as a descriptive study in the period from January 1, to December 31, 2019 at the Institute of Pathology of the Medical Faculty of the University of Belgrade and includes 33 patients. Demographic, clinical and radiological data were obtained from the Bone Tumor Registry. Statistical processing and analysis were done in the Statistical Package for Social Science SPSS Windows version 22 (IBM Chicago, Ilinois, USA). Results: Out of 33 patients, 55% had secondary pelvic tumors, primarily cancer metastases (37%). In 21% of cases, primary malignant bone tumor as diagnosed, and in 12%, primary benign bone tumor. Hematopoietic neoplasms were verified in 12%. Conclusion: Pelvic bone tumors are not common, but these neoplasms, in orthopedic oncology, represents their malignant biological behavior are of great importance. The most common primary malignant tumor in adults is chondrosarcoma, and in children Ewing sarcoma. Highest frequency for pelvic bone metastases has lung cancer. Plasmacytoma in adults, Langerhans cellular histiocytosis in children are hematological neoplasms seen at this site.

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Joseph, JT. « Is Alzheimer Disease a Disease ? » Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 46, s2 (septembre 2019) : S60. http://dx.doi.org/10.1017/cjn.2019.256.

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Problem:Alzheimer disease (AD) is defined as “an irreversible, progressive brain disorder that slowly destroys memory and thinking skills” (National Institute on Aging) and is pathologically characterized by abnormal deposition of neurofibrillary tangles and amyloid plaques. However, these abnormal protein aggregates also accumulate with aging, which complicates the distinction between aging and AD.Results:This presentation will discuss the concepts of disease and then compare and contrast these with the definition of Alzheimer disease. It briefly discusses causality and examines how associations have to be conflated with causality in the pathological diagnoses of neurodegenerative diseases. It also indicates some inherent biases that pathologists have in identifying disease and the pathological changes resulting from diseases. The presentation will present examples from the Calgary Brain Bank of patients without known neurodegenerative disease who die at different ages, as well as different pathological presentations of neurofibrillary tangles and amyloid plaques. Several known causes of AD will be reviewed and contrasted with what is commonly considered “normal aging”.Discussion:This presentation argues that Alzheimer disease pathology represents a final common pattern of changes that results from several or possibly many different aetiologies. Recognizing that these changes have several different causes might better guide future research into late onset dementias.LEARNING OBJECTIVESThis presentation will enable the learner to:1.Consider observational biases used in the diagnoses of different dementias2.Distinguish several aetiologies of Alzheimer-type Neuropathology3.Contemplate how neuropathology has done a disservice in dementia research by focusing on accumulations of abnormal proteins

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Mühlberg, Stephanie. « Die Pathologische Myopie und die Gefahr struktureller Komplikationen mit visuellen Einschränkungen ». Optometry & ; Contact Lenses 1, n^o 2 (30 août 2021) : 57–66. http://dx.doi.org/10.54352/dozv.qgzx4205.

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Purpose. Pathological Myopie (PM) causes structural chan- ges at the posterior segment of the eye that may lead to pathological changes including severe vision loss. The aim of this paper is to describe the pathologies most commonly associated with PM. Material and Methods. The literature review includes the current state of knowledge regarding the structural changes of the posterior segment due to PM, based on theoretical and methodological literature. The selected literature includes nine studies published in 2020 – 2021 as well as reports and assessments of public institutions. Publications by the World Health Organization (WHO), the World Council of Optometry (WCO), the International Myopia Institute (IMI) and the Brien Holden Vision Institute (BHVI) as well as cohort studies with children and adults from China, Singapore, Korea, Taiwan, Japan and Germany were taken into account. Results. Four eye diseases and their relationship to PM are explained and their pathological consequences described. Current therapies to improve the visual acuity in pathologies in the macula are presented. Conclusion. PM often causes structural changes in the macu- lar area. This leads to a significant loss of vision in those affec- ted. Without treatment, PM can lead to blindness. In view of the increase in myopia and the number of myopes worldwide, it is important to sensitize the population to this topic. Keywords myopic retinopathy, lacquer cracks, myopic macular dege- neration (MMD), myopic chorioretinal neovascularization (mCNV), glaucoma

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Sultana, Chowdhury Shamima, Mst Farhana Tarannum Khan, Farjana Islam, Suraiya Khanam, Mst Sharmin Ferdous et Begum Rokeya Anwar. « Clinico-pathological Characteristics and Treatment Modalities of Vulvar Cancer : A Retrospective Analysis ». Bangladesh Medical Research Council Bulletin 48, n^o 1 (5 septembre 2022) : 64–70. http://dx.doi.org/10.3329/bmrcb.v48i1.60662.

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Background: Vulvar cancer is one of the rare malignancies of the female genital tract. Vulvar cancer is predominantly a disease of post-menopausal multiparous women. Objective: The aim of this study was to analyse and report the clinico-pathological features and treatment modalities of patients with vulvar cancer treated at National Institute of Cancer Research and Hospital (NICR&H), Dhaka, Bangladesh. Methods: This was a cross- sectional observational study conducted among 96 vulvar cancer cases treated at National Institute of Cancer Research and Hospital (NICR&H), Dhaka, Bangladesh from 2015 to 2020. The medical records of patients with vulvar cancer were retrospectively reviewed after obtaining approval from the Institutional Review Board (IRB). Clinical details of all vulvar cancer patients and treatment given were collected from the hospital records and were reviewed retrospectively. Results: A total of 96 patients with vulvar cancer were included for this retrospective analysis. The median age was 50 years (range, 12- 85 years) with a mean (±SD) of 50.50±15.12 years. Stages of the disease were: stage I: 27.1% patients; stage II: 22.9% patients; stage III: 30.3% patients; stage IV: 16.7% patients; and unknown stage: 3.1% patient as per International Federation of Gynecology and Obstetrics (FIGO) staging system. Histopathologically, squamous cell carcinoma (SCC) was the most common histologic type (84.4%) followed by adenocarcinoma (5.2%), melanoma (4.2%), basal cell carcinoma (3.1%), and others (3.1%). Most of the patients (45.8%) were treated by surgery with or without adjuvant radiotherapy. About 24.0% of patients were treated primarily by radiotherapy and/or chemo-radiotherapy. Conclusion: Management of vulvar cancer requires multidisciplinary team approach, which is available only in tertiary care centres. The treatment of vulvar cancer is surgery, radiotherapy, chemo- radiotherapy or a combination therapy. Treatment should be individualised based on lesions location and histological type. Bangladesh Med Res Counc Bull 2022; 48(1): 64-70

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Umadevi, F. M., Naresh Moger, Aruna S. Nayak, Namrata D. Hiremath et Nirmala S. Patil. « Identification of Pathological Speech Disorder Using Machine Learning ». Journal of Computational and Theoretical Nanoscience 17, n^o 9 (1 juillet 2020) : 4031–35. http://dx.doi.org/10.1166/jctn.2020.9014.

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Speech is the method of generating specific sounds that convey meaning to the listener. This ability of a person could be hampered due to several reasons leading to speech disorders. A speech disorder refers to any circumstance that affects a person’s capability to create sounds that produce words. According to a survey conducted by All India Institute of Speech and Hearing, Manasgangotri, Mysore, speech impairment is listed as the fifth-highest occurring disability in India. There are different types of speech disorders such as Stuttering, Apraxia, Dysarthria, Dysphonia, that affect a person’s capability to form sounds that permit him/her to converse with other people. Recently computer-based detection of speech disorders has got attention from researchers and doctors as it can be used to detect speech disorders effectively. A similar approach has been proposed in this paper to identify pathological disorders using Support Vector Machines and Gaussian Mixture Model. It can be beneficial to people in rural areas as there is a scarcity of well-trained speech pathologists. Also, equipments needed to identify speech disorders are expensive. Hence there is a need for an automated system to assist a pathologist in detecting speech disorders. In this work, speech dataset from Saarbruecken, related to the above-mentioned diseases was collected and were classified as healthy and unhealthy. An accuracy of 96% was attained using Gaussian Mixture Model.

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Ailamazyan, E. K. « Information about dissertations on obstetrics and gynecology defended at the D.001.21.01 Dissertation Council (Ott Research Institute of Gynecology, Russian Academy of Medical Sciences) in 1999 ». Journal of obstetrics and women's diseases 49, n^o 1 (15 février 2000) : 110–13. http://dx.doi.org/10.17816/jowd89007.

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The results of the thesis research can be recommended for implementation in specialized obstetric hospitals equipped with modern ultrasound devices; in the educational and pedagogical activity of the departments of obstetrics, pediatrics, and pathological physiology of medical universities; and in the lectures for specialists in obstetrics, perinatology, and pathological physiology of the postgraduate medical education academies of Russia.

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Yamatsuji, Tomoki, Naomasa Ishida, Munenori Takaoka, Jiro Hayashi, Kazuhiro Yoshida, Kaori Shigemitsu, Atsushi Urakami, Minoru Haisa et Yoshio Naomoto. « False-Positive Cases of Fluorodeoxyglucose-Positron Emission Tomography/Computed Tomographic Scans in Metastasis of Esophageal Cancer ». Clinical Medicine Insights : Case Reports 10 (1 janvier 2017) : 117954761770340. http://dx.doi.org/10.1177/1179547617703402.

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Of 129 esophagectomies at our institute from June 2010 to March 2015, we experienced three preoperative positron emission tomography-computed tomographic (PET/CT) false positives. Bone metastasis was originally suspected in 2 cases, but they were later found to be bone metastasis negative after a preoperative bone biopsy and clinical course observation. The other cases suspected of mediastinal lymph node metastasis were diagnosed as inflammatory lymphadenopathy by a pathological examination of the removed lymph nodes. Conducting a PET/CT is useful when diagnosing esophageal cancer metastasis, but we need to be aware of the possibility of false positives. Therapeutic decisions should be made based on appropriate and accurate diagnoses, with pathological diagnosis actively introduced if necessary.

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Kakad, Dr Komal, Dr Gajanan Mohniraj Kashid et Dr Harshala Palve. « Clinico-pathological Study and Management of Sinonasal Masses ». VIMS Health Science Journal 9, n^o 5 (30 janvier 2023) : 95–98. http://dx.doi.org/10.46858/vimshsj/9401.

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Background: The Sino nasal tract and para nasal sinuses, in spite of being an anatomically smaller region, have a complex variety of lesions ranging from non- neoplastic to neoplastic. The purpose of this study was to classify various types of non- neoplastic and neoplastic lesions presenting as sinonasal masses at Gajanan ENT Hospital and management of these cases. Methodology: Patients with sinonasal masses, diagnosed at the institute, were included in the study. Previously treated cases, congenital lesions were excluded. Study factors were demographics, diagnostic nasal endoscopy, CT scan PNS, MRI with contrast and histopathology. The data was presented as descriptive statistics with comparing the diagnosis on DNE, CT scan PNS, MRI and histopathology. Diagnosis on histopathological examination was considered to be definitive. Results: A total of 80 patients were included in the study. Demographic data showed equal female and male predominance, with most patients from age group 31-40 years. Nasal obstruction was the most common presenting symptom. 56 patients had non-neoplastic lesions; 20 patients had neoplastic benign lesions while 4 patients had neoplastic malignant lesions. Conclusion: Large number of patients present with different symptoms but need careful examination and appropriate diagnosis. Clinical suspicion and appropriate investigations can guide in timely intervention and management of these patients reducing the morbidity and mortality in these patients. Treatment is to be individualised. Few cases with extensive diseases were managed by medial maxillectomy & Draf 3 procedure.

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Sahu, Arpita, Aditi Venkatesh, Aman Snehil, Abhishek Mahajan, Amit Janu, Ayushi Sahay et Epari Sridhar. « Imaging of supratentorial ependymomas with radio-pathological correlation ». Exploration of Targeted Anti-tumor Therapy 5, n^o 3 (27 juin 2024) : 766–79. http://dx.doi.org/10.37349/etat.2024.00245.

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Aim: Supratentorial ependymoma (STE) is a rare tumor with distinct genetic alterations, whose imaging features have been scarcely studied. This study aims to review the computed tomography (CT) and magnetic resonance imaging (MRI) features of a cohort of histopathologically proven STE to identify the distinguishing features of STE, and look for specific signs of zinc finger translocation associated (ZFTA) fused STEs. Methods: Ethical clearance was obtained from the institutional ethics committee. The magnetic resonance (MR) images, CT images when available, clinical details, and pathological reports of 25 patients from a single institute with histopathologically proven STE were retrospectively reviewed. Imaging features, demographic details, pathological and molecular features, and type of surgical resection were described and tabulated. Relevant associations with imaging features were computed and tabulated. Results: The study showed that STEs are common in the pediatric population with no sex predilection. The periventricular location was the most common. A significant association between periventricular location and the presence of a cystic component (P value = 0.023) and the presence of the periwinkle sign/stellate sign (P value = 0.045) was found. Common features of ZFTA fused STEs included periventricular or intraventricular location, cystic component, necrosis, and the periwinkle sign. A significant association was found between ZFTA fusion and cystic component (P value = 0.048). Conclusions: This study attempts to identify the imaging features of STEs and their associations with molecular pathology and surgical outcome, and the distinguishing features of ZFTA fused STEs.

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Zeidan, Ashraf, Matta Gerges, Shimaa H. Shaban et Mayada Fawzy. « Right and Left Colon Cancer : Clinico-Pathological Features and Treatment Results (South Egypt Cancer Institute Experience) ». Journal of Cancer Therapy 11, n^o 07 (2020) : 433–47. http://dx.doi.org/10.4236/jct.2020.117037.

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Huang, Kuo-How, Shiu-Dong Chung, Shyh-Chyan Chen, Shih-Chieh Chueh, Yeong-Shiau Pu, Ming-Kuen Lai et Wei-Chou Lin. « Clinical and pathological data of 10 malignant pheochromocytomas : Long-term follow up in a single institute ». International Journal of Urology 14, n^o 3 (mars 2007) : 181–85. http://dx.doi.org/10.1111/j.1442-2042.2007.01687.x.

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Raza, Mohd Arshad, Sujoy Mukherjee, Tanmay Prasad et Ranjan Agrawal. « SPECTRUM OF CLINICO - PATHOLOGICAL PRESENTATIONS OF GALLSTONE DISEASES IN A TERTIARY CARE INSTITUTE IN ROHILKHAND REGION ». Journal of Evolution of Medical and Dental Sciences 4, n^o 81 (7 octobre 2015) : 14190–200. http://dx.doi.org/10.14260/jemds/2015/2017.

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Salama, A., A. Abdelrahman, I. Mourad, I. Loay, A. Hussein et E. Ebeid. « Recent multidisciplinary approach In thoraco pulmonary Ewing sarcoma, Clinico - Pathological Study, National Cancer Institute Experience, Cairo ». European Journal of Surgical Oncology 45, n^o 2 (février 2019) : e138. http://dx.doi.org/10.1016/j.ejso.2018.10.468.

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Sidhu, Manjinder Singh, Sumeet Jain, Gurpreet Brar, Kunal Dhall, Sandhya Sood, Ritu Aggarwal, Kunal Jain et al. « Pattern of failure after adjuvant radiation therapy in oral cavity cancer patients : Data from tertiary care institute in North India ». Bengal Journal of Cancer 3, n^o 1 (2023) : 4–10. http://dx.doi.org/10.4103/bjoc.bjoc_17_23.

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Abstract Objectives: To review failure patterns in oral cavity squamous cell carcinoma treated with surgery and adjuvant radiation therapy. Materials and Methods: All patients with biopsy-proven stage I-IVB oral cavity squamous cell carcinoma (OCSCC) treated with surgery and adjuvant therapy between 2018 and 2022 were evaluated. Outcome measures were 3-years loco-regional recurrence (LRR), overall survival (OS), and progression free survival (PFS). LRR was spatially localized in relation to contour and dose distribution. Results: A total of 85 patients treated between years 2018 to 2022 were evaluated with median follow-up of 19 months. Disease subsites were oral tongue (37.6%) and bucco-alveolar complex (62.4%). Of a total of 25.9% failures, 16/85 (18.8%) were local, 9/85 (10.6%) were regional, 18/85 (21.2%) were locoregional, and 10/85 (11.8%) were distant. For LRR, total in-field failure was 11.8%, marginal failure was 4.7%, and out-of-field failure was seen in 2.4% cases. The 3-year actuarial local, regional control, and LRR in our study were 69%, 84%, and 67%, respectively. The cumulative rates of OS were 72% and PFS was 56%. On univariate analysis, independent factors for local failure were perineural invasion (PNI) (OR = 5.89, P = 0.03), lymph vascular space invasion (LVI) (OR = 3.69, P = 0.05), and pathological N3 (OR = 3.69, P = 0.02). For regional, failure was PNI (OR = 4.53, P = 0.038). For locoregional, failure was PNI (OR = 6.13, P = 0.002) and for distant, failure were PNI (OR = 5.80, P = 0.013), pathological N3 (OR = 4.35, P = 0.03) and LVI (OR = 4.66, P = 0.03). On multivariate Cox proportional hazard analysis, for local, failure risk factors were PNI (HR = 4.32, P = 0.01) and pathological N3 (HR = 3.27, P = 0.047), for locoregional, failure was PNI (HR = 4.42, P = 0.006), and for distant, failure was PNI(HR0 = 4.29, P = 0.05). Conclusions: In our cohort of patients, the most common failure was in-field LRR. PNI was significantly associated with local, locoregional, and distant failure on Cox analysis. In addition to PNI, pathological N3 was the cause of local failure.

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Sukhin, D. G., S. S. Pirogov, V. I. Ryabtseva, I. V. Kuprina, O. K. Yutsevich, I. B. Perfiliev, G. F. Minibaeva, A. S. Vodoleev, L. V. Telegina et A. D. Kaprin. « Endoscopic diagnosis and treatment of primary multiple noninvasive malignant neoplasms of the stomach : clinical case ». Experimental and Clinical Gastroenterology, n^o 5 (18 mai 2024) : 100–104. http://dx.doi.org/10.31146/1682-8658-ecg-225-5-100-104.

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This clinical case describes a rare combination of early stage cancer and sporadic neuroendocrine tumor in stomach. The patient 57 years old admitted to P. A. Hertsen Moscow Oncology Research Institute for diagnostics and treatment for the gastric adenoma. Upper GI endoscopy performed in P. A. Hertsen Institute, detected two tumors: a sporadic neuroendocrine tumor in the middle part of the body stomach and early cancer in the antrum. With NBI (Narrow-Band Imaging), signs of malignancy were found in both tumors. А plan for therapeutic and diagnostic endoscopic surgical interventions was implemented: two sequential endoscopic submucosal dissection (ESD). This treatment confirmed as radical, according to the results of the pathological examination.

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Opimakh, S. G. « THE INVENTION OF COMPUTED TOMOGRAPHY AND ITS SIGNIFICANCE IN THE HISTORY OF PULMONOLOGY ». Ukrainian Pulmonology Journal 32, n^o 1 (2024) : 66–74. http://dx.doi.org/10.31215/2306-4927-2024-32-1-66-74.

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Imaging diagnostic methods in pulmonology originate from the discovery of X-rays. Radiography is the first-line tool for chest imaging, but in many cases its capabilities are limited. The aim was to study the history of the invention of computed tomography. Since the radiogram is a two-dimensional summation image of a three-dimensional anatomical structure, there was a need to visualize separate layers of the pathological process. Since 1913, many technical solutions of tomography have been tested. Linear tomography for some time served for the diagnosis of lung pathology, helped to determine the localization more accurately, examine a prevalence, nature and structure of the pathological process, to detect small pathological formations and cavities. But the quality of tomography was not satisfactory. The two outstanding inventors of computed tomography who were awarded the 1979 Nobel Prize in Medicine were not the physicians. Allan McLeod Cormack (Professor and Head of the Institute of Physics at Tufts University, Medford, Massachusetts, USA) was the first to outline the principles of cross-sectional tissue reconstruction in an organ based on X-ray projections in 1963. Godfrey Newbold Hounsfield (Head of Medical Research at Electric and Musical Industries, Middlesex, England) not only reproduced the mathematical algorithms of the technique, but also designed the tomograph and directly participated in its clinical implementation in 1971. Among the developers of the idea of three-dimensional X-ray tomography in 19571958 were the scientists of Kyiv Polytechnic Institute Semyon Tetelbaum and Boris Korenblyum. Key words: radiology, computed tomography, history of pulmonology.

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Gasanaliev, N. « Helminthiasis of Infection Ruminants in Various Landscapes of the Sheki-Zagatala Region of Azerbaijan ». Bulletin of Science and Practice 7, n^o 9 (15 septembre 2021) : 144–48. http://dx.doi.org/10.33619/2414-2948/70/16.

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In order to study the epizootic situation of helminthic spread, 430 samples of feces and pathological material from small ruminants were taken from livestock farms of the Sheki-Zagatala region. The materials were send for research to the Department of Parasitology of the Scientific Research Veterinary Institute. The research results were analyzed for mountainous, foothill, flat areas and for the seasonality of the region.

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Stevanovic, V., Z. Blagojevic, Z. Ganic, I. Diklic, A. Crnobaric et M. Glisic. « Intramedullary fixation and proximal femoral fractures : Diversity in use through case reports ». Acta chirurgica Iugoslavica 57, n^o 1 (2010) : 35–40. http://dx.doi.org/10.2298/aci1001035s.

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Proximal femoral fractures, including intertrochanetric and subtrochanteric with diaphiseal propagation represent a significant challenge in orthopedic surgery, especially in older population. Retrospective analysis of patients, after the application of 'Bi Nail (Bioimpianti Inc.) intramedullary nail for fractures and pathological conditions of proximal femur, was done at the Department of Adult Orthopedics, Institute of Orthopedic surgery Banjica, during the three year period. We present patients with complex fractures and pathological conditions (metastasis and pseudoarthrosis) of proximal femur; most of the fractures were result of effects of low energy, and the most common pathological fracture is due to metastasis of breast cancer. The analysis included the technical characteristics and duration of surgery, intraoperative and postoperative complications as well as the coalescence time of fracture healing and postoperative quality of life after rehabilitation. We believe that the described surgical method, although technically demanding, with a variable length duration of surgery and treatment of high risk elderly patients, provides stable fracture fixation with early rehabilitation to improve the quality of life.

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