Bibliographies thématiques / Pathological Institute

Littérature scientifique sur le sujet « Pathological Institute »

Auteur : Grafiati
Publié le 25 juillet 2024

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Articles de revues sur le sujet "Pathological Institute"

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Shah, Rushabh Jitendra, et Pradeep Vaideeswar. « Candidal endocarditis : a single institute pathological analysis ». Pathology 46 (2014) : S62. http://dx.doi.org/10.1097/01.pat.0000454313.47062.94.

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Vaideeswar, Pradeep. « Candidial Endocarditis : A Single-Institute Pathological Analysis ». Mycopathologia 180, no 1-2 (22 février 2015) : 81–87. http://dx.doi.org/10.1007/s11046-015-9876-3.

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Poppe, H., B. Dillinger et S. Lentner. « Pathological gambling and comorbidities ». European Psychiatry 26, S2 (mars 2011) : 92. http://dx.doi.org/10.1016/s0924-9338(11)71803-x.

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Pathological gambling accumulates frequently in connection with other diseases. This is documented both by studies and clinical observations, whereby no causalities can be derived, which underlying disease led to further diseases. Nevertheless different studies show similar results that pathological gambling arises increased in connection with substance dependence, depressive disorders, obsessive compulsive disorders and also personality disorders. These results stated in the literature also reflect the clinical observations of the Anton Proksch Institute.In the following presentation we will try to figure out the results of inpatients with the diagnosis pathological gambling, that were treated in the Anton Proksch Institute in the years 2008, 2009 and 2010. We find a range of comorbititys longing from substance abuse to personality disorders.
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Molochkova, Yulia V., et A. N. Khlebnikova. « Clinical and pathological red flat depriving association ». Russian Journal of Skin and Venereal Diseases 19, no 5 (15 octobre 2016) : 286–90. http://dx.doi.org/10.18821/1560-9588-2016-19-5-286-290.

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Knowledge of the morphological structure of atypicalforms of lichen planus is necessaryfor the correct diagnosis of lichen planus. Due to the large number of atypicalforms, diagnosis often requires a histological examination of the affected skin. The article describes pathological features of typical and some atypical forms of lichen planus, observed in recent years in the department of dermatology of Moscow Regional Research and Clinical Institute.
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Tcvetkova, M. M. « The formation and development of pediatrics and pediatric education in Primorye ». Pacific Medical Journal, no 4 (5 janvier 2022) : 5–9. http://dx.doi.org/10.34215/1609-1175-2021-4-5-9.

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The article presents historical information about the development of pediatrics and pediatric education in Primorsky Region. It started from the establishment of the pediatric faculty of the Vladivostok Medical Institute in 1969 to the present day. Main directions of scientific and pedagogical activities of pediatric profile departments are highlighted. The departments were reorganized in 2016 into the Institute of Pediatrics; departments of normal and pathological physiology, pathological anatomy, and foreign languages. The article also indicates those people who were at the origins of pediatrics and pediatric education in Primorye.
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Dobrynin, V. A. « 125 years of the Department of Pathological Anatomy at Kazan Medical Institute ». Kazan medical journal 70, no 2 (15 avril 1989) : 152–53. http://dx.doi.org/10.17816/kazmj99965.

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According to the June 18, 1863 University Charter, the fourth department of pathological anatomy in Russia (after Moscow, St.Petersburg and Derpt) was created at the Kazan University Medical Faculty. On October 21, 1863 A.V. Petrov (1837-1885) was appointed the first senior lecturer of the Department of Pathiatomy, who left his mark not only as an organizer of educational process, but also as a scientist and public figure. His studies on typhoid fever and uremia are classic. His experimental work, which showed the contagiousness of tuberculosis, anticipated the discovery of Mycobacterium tuberculosis by R. Koch. He gave much strength and energy to the Kazan Society of Physicians, of which he was the chairman for many years.
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Moussa, Sabri, et Wael H. El-Sheshtawy*. « Pathological Pattern of Urinary Bladder Cancer : Data from a Single Egyptian Institute ». Research in Oncology 13, no 1 (1 juin 2017) : 14–17. http://dx.doi.org/10.21608/resoncol.2017.869.1023.

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Chandrashekhar, Thotadamane Nagaraja, Anita Mahadevan, Santosh Vani, Thagadur Chickabasaviah Yasha, Somanna Sampath, Bangalore Anantaraman Chandramouli, Bhagavatula Indira Devi, Hanumantapura Ramalingaiah Arvinda et Susarla Krishna Shankar. « Pathological spectrum of neuronal/glioneuronal tumors from a tertiary referral neurological Institute ». Neuropathology 32, no 1 (17 mars 2011) : 1–12. http://dx.doi.org/10.1111/j.1440-1789.2011.01206.x.

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Chaudhari, Dr Bharat Muljibhai, et Dr Ashish N. Madiya. « Clinic Pathological Evaluation of Benign Breasts Lesion ». Tropical Journal of Pathology and Microbiology 7, no 1 (20 janvier 2021) : 40–43. http://dx.doi.org/10.17511/jopm.2021.i01.06.

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Introduction: Benign breast lesions are more common than malignant tumours. Hence recognizingthem is important from the viewpoints of therapy and prognosis. Methodology: The materials forthe study comprised of resected specimens of breast lesions received in the pathology departmentKarnataka Institute of Medical Sciences, Hubballi from May 2010 to April 2015. Results: A total of600 cases of benign breast lesions were recorded. Fibroadenoma was the commonest benign breastlesions comprising 70.82%, followed by fibrocystic disease 12%, benign phyllodes tumour 8.3%.The majority of benign breast lesions occurred in the 2nd decade and 3rd decade. Conclusion:Benign breast lesions were common. Conclusion: The most frequently encountered breast lesionswere fibroadenomas. So recognizing them is important for therapy and prognosis.
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Ravilov, R. Kh, et I. N. Nikitin. « PROFESSOR BOHL KARL GENRIKHOVICH - PATRIARCH OF VETERINARY SCIENCE AND EDUCATION (1871-1959) ». Scientific Notes Kazan Bauman State Academy of Veterinary Medicine 246, no 2 (1 juin 2021) : 177–81. http://dx.doi.org/10.31588/2413-4201-1883-246-2-177-181.

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The article describes the biography of Professor K. G. Bol, his scientific achievements, contribution to the development of the Kazan Veterinary Institute and the Department of Pathological Anatomy. His work is reflected in the Kazan State University, the Kazan State Institute of Advanced Training of Doctors, the Tatar Central Executive Committee, the Kazan City Council of People's Deputies.
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Thèses sur le sujet "Pathological Institute"

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Schmitz, Birte [Verfasser], Xiaoqi [Akademischer Betreuer] Ding et Karin [Akademischer Betreuer] Weißenborn. « Investigation of metabolic and microstructural alterations in human brain under physiological and pathological conditions by using magnetic resonance imaging and 1H and 31P magnetic resonance spectroscopy / Birte Schmitz ; Akademische Betreuer : Xiaoqi Ding, Karin Weißenborn ; Institut für Diagnostische und Interventionelle Neuroradiologie ». Hannover : Bibliothek der Medizinischen Hochschule Hannover, 2020. http://d-nb.info/1225413656/34.

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Livres sur le sujet "Pathological Institute"

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NATO Advanced Study Institute on Biomechanics of Normal and Pathological Human Articulating Joints (1983 Estoril). Biomechanics of normal and pathological human articulating joints : Proceedings of the NATO Advanced Study Institute on Biomechanics of Normal and Pathological Human Articulating Joints, Estoril, Portugal, 20 June-1 July, 1983. Dordrecht : Martinus Nijhoff, 1985.

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Pathologists, Royal College of, Institute of Biomedical Science et Association of Clinical Biochemists, dir. The retention and storage of pathological records and archives : Report of the Working Party of the Royal College of Pathologists and the Institute of Biomedical Science. 2e éd. London : Royal College of Pathologists, 1999.

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H, Eliot Lawrence, et New York (State). Office of Mental Health. Bureau of Program Policy and Development, dir. Pathological gambling : Summations from the first Statewide Training Institute, presented by the New York State Office of Mental Health, Division of Clinical Programs, Bureau of Program Policy and Development, November 8-10, 1982, Albany, New York. [Albany, NY] : New York State Office of Mental Health, 1985.

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National Institutes of Health (U.S.). Clinical Center. The Clinical Pathology Department at the National Institutes of Health. [Bethesda, Md.?] : Clinical Center, U.S. Dept. of Health and Human Services, Public Health Service, National Institutes of Health, 1994.

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National Institutes of Health (U.S.). Clinical Center. Becoming a patient at the National Institutes of Health, Clinical Center. [Washington, D.C.?] : Clinical Center, National Institutes of Health, 1995.

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Tral’, Tat’yana, Gulrukhsor Tolibova, Igor Kogan et Anna Olina. Embryo losses. Atlas. ru : Publishing Center RIOR, 2023. http://dx.doi.org/10.29039/978-5-907218-78-9.

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Histologic examination of abortive material is the basic approach to identify the etiology of miscarriage. Morphological diagnostics in case of embryo loss makes it possible to draw up the plan to fully prepare the woman for future pregnancy, whether spontaneous or after fertility treatment, increasing the chance of a favorable outcome. This educational book contains the data from various studies of the endometrium and abortive material undertaken at the Ott Research Institute of Obstetrics, Gynecology and Reproductology. Histology illustrations are supplemented with images of immunohistochemical studies and confocal laser scanning microscopy photos, as well as detailed text descriptions. Images can be viewed in the atlas, with QR codes linking to high-resolution electronic photos. This edition highlights the features of endometrial structural changes related to different modes of conception, the details of assessing abortive material, trophoblast chromosomal abnormalities, anembryony, hydatidiform mole, choriocarcinoma, as well as examination of embryo losses of various origins. The atlas is intended for pathologists, obstetrician-gynecologists and heads of women’s health clinics, perinatal centers, gynecological departments of general hospitals, fertility specialists, clinical laboratory diagnostics specialists, fellows and heads of departments of obstetrics and gynecology, pathological anatomy, students of all forms of continuous medical education, graduate students and clinical residents.
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(Editor), Jeffrey J. Marotta, Judy A. Cornelius (Editor) et William R. Eadington (Editor), dir. The Downside : Problem and Pathological Gambling (Institute of Gambling & Commercial Gaming). University of Nevada, Reno Bureau of Business, 2002.

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VIRCHOW, RUDOLF. Cellular Pathology as Based Upon Physiological and Pathological Histology, 20 Lectures Delivered in the Pathological Institute of Berlin, During Feb. Mar. and Apr. 1858. Franklin Classics, 2018.

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Cellular Pathology As Based upon Physiological and Pathological Histology, 20 Lectures Delivered in the Pathological Institute of Berlin, During Feb. Mar. and Apr. 1858. Creative Media Partners, LLC, 2022.

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Virchow, Rudolf. Cellular Pathology As Based upon Physiological and Pathological Histology, 20 Lectures Delivered in the Pathological Institute of Berlin, During Feb. Mar. and Apr. 1858. Creative Media Partners, LLC, 2018.

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Chapitres de livres sur le sujet "Pathological Institute"

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Banchereau, Jacques, John Connolly, Tiziana Di Pucchio, Carson Harrod, Eynav Klechevsky, A. Karolina Palucka, Virginia Pascual et Hideki Ueno. « Dendritic Cells : Biological and Pathological Aspects ». Dans National Institute of Allergy and Infectious Diseases, NIH, 409–27. Totowa, NJ : Humana Press, 2008. http://dx.doi.org/10.1007/978-1-59745-569-5_45.

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Semonella, Michelle, Pietro Cipresso, Cosimo Tuena, Alessandra Parisi, Michelle Toti, Aurora Elena Bobocea, Pier Giovanni Mazzoli et Giuseppe Riva. « Testing a Deactivated Virtual Environment in Pathological Gamblers’ Anxiety ». Dans Lecture Notes of the Institute for Computer Sciences, Social Informatics and Telecommunications Engineering, 242–49. Cham : Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-25872-6_20.

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Lin, Xiang, Zhang Juxiao, Yin Lu et Ji Wenpei. « Research on Application of Deep Learning in Esophageal Cancer Pathological Detection ». Dans Lecture Notes of the Institute for Computer Sciences, Social Informatics and Telecommunications Engineering, 95–105. Cham : Springer Nature Switzerland, 2024. http://dx.doi.org/10.1007/978-3-031-50580-5_9.

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Virchow, Rudolf. « From Cellular Pathology (1858) ». Dans Literature and Science in the Nineteenth Century. Oxford University Press, 2009. http://dx.doi.org/10.1093/owc/9780199554652.003.0053.

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Rudolf Virchow’s Cellular Pathology consists of a series of lectures ‘taken down in short-hand, just as they were delivered’ at the Berlin Pathological Institute in 1856–7. His audience consisted mainly of practising physicians, and he supported his claims with numerous microscopical preparations which...
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Yokoyama, Olga T. « On the establishment of a new department at the Leningrad Postgraduate Medical Institute ». Dans Pavlov on the Conditional Reflex, 513–14. Oxford University PressNew York, 2023. http://dx.doi.org/10.1093/oso/9780190941871.003.0063.

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Abstract Out of the enormous amount of material generated by the research on the higher nervous activity in dogs using the method of conditional reflexes, I will discuss three points today, specifically related to pathological disorders of this activity. They are: the strength of the two basic nervous processes of excitation and inhibition, then the correlation of their strengths—their balance—and finally their mobility. These points, on the one hand, form the basis of the typology of higher nervous activity—and types, notably, play a big role in the genesis of nervous and so-called psychiatric diseases; on the other hand, they make it possible to capture the characteristic changes that occur in the pathological states of this activity.
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Holmes, Frederic Lawrence. « The Research Apprentice ». Dans Hans Krebs, 121–61. Oxford University PressNew York, NY, 1991. http://dx.doi.org/10.1093/oso/9780195070729.003.0005.

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Abstract At the beginning of January, 1925, Hans Krebs walked through the entrance to the Pathological Institute of the Charite Hospital and into the Division of Chemistry, to begin his practical training in the methods of the science taught there. In one large laboratory room with many benches new students like himself worked side-by-side with more advanced students, with research assistants to the director, and with a few independent investigators. David Nachmansohn, who had already been working enthusiastically in the laboratory for several months, probably told Krebs that he could expect to learn a lot there.
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Ankolekar, Sandeep, et Michela Simoni. « Post-stroke cognitive impairment ». Dans Stroke in the Older Person, 381–98. Oxford University Press, 2020. http://dx.doi.org/10.1093/med/9780198747499.003.0025.

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‘Post-stroke cognitive impairment’ explores in great depth the burden of post-stroke cognitive impairment, its pathological substrates and clinical characteristics, the causes of these impairments, post-stroke dementia, and the risk factors implicated. The chapter examines common definitions (vascular cognitive impairment, vascular dementia, post-stroke cognitive impairment), the DSM-5 criteria (Diagnostic and Statistical Manual of Mental Disorders-5), ICD-10 criteria (International Classification of Diseases), NINDS-AIREN criteria (National Institute of Neurological Disorders and Stroke and the Association Internationale pour la Recherche et l’Enseignement en Neurosciences) for vascular dementia, and vascular mild cognitive impairment. The VASCOG (vascular cognitive disorder) criteria are also described. A pragmatic approach to investigations and various assessment scales, a description of important clinical trials, and the management of these disorders are also included.
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Pouncey, Claire. « Psychopathology without Nosology : The Research Domain Criteria Project as Normal Science ». Dans Extraordinary Science and Psychiatry. The MIT Press, 2017. http://dx.doi.org/10.7551/mitpress/9780262035484.003.0005.

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Although the National Institute of Mental Health characterizes its Research Domain Criteria program as a “paradigm shift,” its change in emphasis from discrete mental disorders to psychophysiological constructs does not depart dramatically from prior research strategies. The RDoC program supports psychopathology research that utilizes newer, biologically-based investigational methods; avoids pre-existing conceptions of mental disorders; and provides insight into the full range of psychological functioning, from normal to pathological. However, it maintains the methodological rules of the existing psychopathological paradigm. This chapter traces the conceptual history of construct validity to show its consistency across disorder-based and construct-based approaches to the study of psychopathology. Because the RDoC research program is grounded in construct validity and aims to develop existing theory, it does not constitute a paradigm shift in the Kuhnian sense, but simply rejects mental disorders as scientifically legitimate constructs.
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Oxford, John, Paul Kellam et Leslie Collier. « Retroviruses : HIV-1 and -2 and HTLV ». Dans Human Virology. Oxford University Press, 2016. http://dx.doi.org/10.1093/hesc/9780198714682.003.0027.

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This chapter recounts the first discovery of a retrovirus. This was made as long ago as 1910 by Peyton Rous, who worked at the Rockefeller Institute for Medical Research in New York. This agent, avian sarcoma virus, induced tumours in muscle, bone, and other tissues of chickens. The chapter highlights the discovery of other retroviruses which caused tumours in the 1930s. However, these viruses were regarded as laboratory curiosities until the description of feline leukaemia virus, a gammaretrovirus, which was first discovered in the 1960s and appeared to spread naturally in household cats. The chapter mentions the Visna Virus of sheep, discovered in 1954. This was shown to persistently infect sheep and could lead to ovine progressive pneumonia. The discovery if HIV-1, which causes AIDS, led to a surge of interest in this previously understudied family of viruses, and the chapter examines the properties as well as the clinical and pathological aspects of HIV in detail.
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Salford, Leif G. « The development of echoencephalography in Sweden ». Dans Ultrasound in Clinical Diagnosis. Oxford University Press, 2011. http://dx.doi.org/10.1093/oso/9780199602070.003.0010.

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Although neurosurgery has a long history it was thanks to brave pioneering neurosurgeons such as Harvey Cushing in the United States — and in Sweden Herbert Olivecrona — that the speciality made huge progress during the first half of the 20th century. However, around 1950, the possibility to reveal pathological processes taking place inside the closed skull, was still very restricted. The only available rapid procedure was the neurological examination of the patient. X-ray of the skull is of restricted value, pneumo-encephalography was much too complicated and time-consuming for acute situations, and angiography was still in its infancy. Thus the neurosurgeon, receiving an acute patient with a suspected intracranial haematoma, had to make a qualified guess about where to start placing his trephine on the skull in order to save the life of the patient — often within minutes in the case of a bleeding between the skull bone and the dura. The mortality in those days was 40 % , often because the diagnosis was made too late. Thanks to an ingenious Swedish neurosurgeon, Lars Leksell, working at Lund University Hospital, a new approach to reveal the secrets inside the skull was introduced in clinical praxis — echoencephalography. Lars Leksell graduated from the Karolinska Institute (KI) and received his neurosurgical training in Herbert Olivecrona’s department from 1935. He volunteered as a neurosurgeon in the Finnish winter war in 1940 in Karelia. His team could operate on 24 head injuries per 24 hours and already by this point, Leksell showed his creative mind in constructing the double-action rongeur for more efficient removal of shell-splinters from the vicinity of the spinal cord. In 1941 he joined Professor Ragnar Granit (1967 Nobel laureate in Medicine) at the Institute of Neurophysiology where he presented his thesis on gamma nerve fibres in 1945. In 1946 he became the chief of the new neurosurgical unit in Lund and in 1958 he was appointed the first Professor of Neurosurgery at Lund University. In 1960 he succeeded Olivecrona as Professor and Chairman of the Neurosurgical Department at the Karolinska Institute/Hospital.
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Actes de conférences sur le sujet "Pathological Institute"

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STONE, SHELDON. « PATHOLOGICAL SCIENCE ». Dans Proceedings of the Theoretical Advanced Study Institute in Elementary Particle Physics. WORLD SCIENTIFIC, 2001. http://dx.doi.org/10.1142/9789812811509_0015.

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SANTOS, Anny Caroline Nobre, Macgyver Viana BEZERRA et Sizy Brenda de MELO. « Incidence of pathological manifestations and proposition of corrective measures in an Institute of Higher Education in the city of Quixadá/CE ». Dans XIX International Conference on Building Pathology and Constructions Repair. Universidade Federal do Cear�, 2023. http://dx.doi.org/10.4322/cinpar.2023.009.

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Saikrishnan, Neelakantan, Jean-Pierre Rabbah, Paul Gunning, Ikay Okafor, Arvind Santhanakrishnan, Laoise McNamara et Ajit P. Yoganathan. « Experimental Platforms for Validation of Computational Approaches to Simulating Cardiovascular Flows ». Dans ASME 2013 Conference on Frontiers in Medical Devices : Applications of Computer Modeling and Simulation. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/fmd2013-16028.

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This paper describes three different versions of left heart simulators that have been developed at the Cardiovascular Fluid Mechanics Laboratory at Georgia Institute of Technology, specifically designed to provide high fidelity experimental datasets necessary for rigorous validation of computational tools. These systems are capable of simulating physiological and pathological flow, pressure and geometric conditions, and can be investigated using a variety of experimental tools to measure relevant biomechanical quantities. The development of such robust simulators is a critical step in ensuring applicability of patient specific computational tools.
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Ram, Dharma. « Oral Abstract ». Dans 16th Annual International Conference RGCON. Thieme Medical and Scientific Publishers Private Ltd., 2016. http://dx.doi.org/10.1055/s-0039-1685335.

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Introduction: Uterine sarcoma accounts for nearly 3% of all uterine malignancies. They have 4 major pathology includes endometrial stromal sarcoma high grade, ESS low grade, uterine leiomyosarcoma (uLMS) and undifferentiated uterine sarcoma (UUS). Recent WHO classification 2014, recognizes low grade ESS and high grade ESS as distinct entity. They differ from endometrial carcinoma in their aggressive nature and poor prognosis. We review our database and found total 44 eligible patient treated at our institute. Materials and Methods: Its retrospective analysis of computer based database of our institute from January 2009 to December 2015. We analyzed demographic, pathological, treatment and survival data. Results: Total 44 patient treated for uterine sarcoma at our institute. Among these 16 were operated at our institute during study period. Here we reporting results of operated patients at our institute. The histological diagnosis LMS (5/16), ESS-L (4/16), MMMT (3/16), UUS (3/16) and ESS-H (1/16). Stage distribution was stage I, (6/16) stage II, (5/16) stage III, (3/16) stage IV, (0/16) and unknown stage (2/16). Two patients underwent completion surgery for outside myomectomy. The adjuvant treatment was CT in 3/16, CT with RT in 7/16, HT in 4/16 and one lost to follow up with one was put on observation. Median follow up is 30 month with 14 patients alive and one lost to follow up. At last follow up 4 patients alive with metastatic disease and 10 patients alive with no evidence of disease. Conclusion: Uterine sarcoma are uncommon disease with
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Rodrigues, Fábio Francisco de Oliveira, Rebeca Belleza Ramacharaka Barros, Lethicia Borges Pinheiro, Carlos Elias Fristachi, Rodrigo Macedo de Carvalho, Ana Carolina Tretini Izar, Etienne de Albuquerque Bastos et Vinicius Miranda Borges. « SURVEY OF BREAST CANCER CASES : PATIENTS WHO OBTAINED A COMPLETE PATHOLOGICAL RESPONSE AFTER NEOADJUVANT CHEMOTHERAPY AT THE CANCER INSTITUTE DR. ARNALDO VIEIRA DE CARVALHO IN THE YEARS 2013 AND 2014 ». Dans Abstracts from the Brazilian Breast Cancer Symposium - BBCS 2021. Mastology, 2021. http://dx.doi.org/10.29289/259453942021v31s2054.

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Neoadjuvant treatment in breast cancer has some advantages, in that the treatment of micrometastatic disease has increased because of the higher degree of performing conservative surgery and reducing tumor burden. The complete pathological response (CPR) is defined as the absence of invasive carcinoma in the anatomopathological study of breast tissue and axillary lymph nodes. The aim of this study is to analyze patients diagnosed with breast cancer between the years 2013 and 2014, taking into account the following variables: age, chemotherapy (type of medication and duration), CPR, and histological subtypes. Medical records were analyzed. Of 31 patients who underwent neoadjuvant chemotherapy, three obtained a CPR. Of these, two had hybrid HER2 histological subtype, one negative triple, and one Luminal A. Method: A study was conducted in which the eligible population was composed of women diagnosed with breast cancer (cid c50) whose treatment and follow-up was performed by the mastology team of the Dr. Arnaldo Cancer Institute. Patients who were diagnosed from 2013 to 2014 were selected. For the description of the cases, variables such as tumor subtype, age, Qt neo performance, and CPR were analyzed. Clinical and pathological characteristics were collected regarding diagnosis and type of treatment, laterality, tumor staging, and the number of compromised lymph nodes. Subsequently, the response to the end of the first treatment — Qt neo, a classification, was performed: no evidence of the disease, partial remission, disease in progression, death, or CPR. Results: We evaluated 163 patients diagnosed with breast cancer between 2013 and 2014 at the Dr. Arnaldo Cancer Institute and also included 31 patients who underwent Qt neo. It was observed that of these three had CPR, 68 were older than 60 years and the most common histological type was invasive ductal carcinoma.
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Craig, Christopher, Simon Bailey, Nadira Narine, David Shelton, Sakinah Thiryayi, Durgesh Rana et Haider Al-Najjar. « Performance of Endobronchial Ultrasound Transbronchial Needle Aspiration (EBUS-TBNA) with Rapid On-Site Evaluation (ROSE) in the pathological subtyping and molecular testing of non-small cell lung cancer (NSCLC) at a UK institute ». Dans ERS International Congress 2018 abstracts. European Respiratory Society, 2018. http://dx.doi.org/10.1183/13993003.congress-2018.pa868.

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« Case series : Breast and ovarian cancer syndrome ». Dans 16th Annual International Conference RGCON. Thieme Medical and Scientific Publishers Private Ltd., 2016. http://dx.doi.org/10.1055/s-0039-1685364.

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Aims and Objectives: To report a series of cases with breast and ovarian carcinomas either in same patient or in a family and identifying the importance of BRCA 1, 2 genetic testing in such individuals. Materials and Methods: The medical records of breast and ovarian cancer patients operated over past 3 years at a single institute were reviewed retrospectively and their clinical profile, family history, final pathological reports and follow up data was collected. Results: 8 patients were found to have breast and ovarian malignancies, out of which 3 had synchronous breast and ovarian cancers, 4 had metachronous and 1 patient with ovarian cancer had history of breast cancer in family. Median age of presentation to the hospital was 47 years and median time interval in metachronous disease patients was 5.5 years. Conclusion: About 5% of people who have breast cancer and about 10% of women who have ovarian cancer have HBOC, caused by germline mutation in BRCA 1, 2 gene. These individuals have increased risk of developing breast cancer at younger age, TNBC, or developing a second primary in breast or ovary plus an overall risk of breast/ovarian/prostate/pancreatic malignancies in other family members due to inheritable mutation. Identification of BRCA mutation in such individuals can help family members to undergo genetic counseling and follow different screening and prevention guidelines from general population thus reducing the cancer risks.
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« Case series : Breast and ovarian cancer syndrome ». Dans 16th Annual International Conference RGCON. Thieme Medical and Scientific Publishers Private Ltd., 2016. http://dx.doi.org/10.1055/s-0039-1685348.

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Aims and Objectives: To report a series of cases with breast and ovarian carcinomas either in same patient or in a family and identifying the importance of BRCA 1,2 genetic testing in such individuals. Materials and Methods: The medical records of breast and ovarian cancer patients operated over past 3 years at a single institute were reviewed retrospectively and their clinical profile, family history, final pathological reports and follow up data was collected. Results: 8 patients were found to have breast and ovarian malignancies, out of which 3 had synchronous breast and ovarian cancers, 4 had metachronous and 1 patient with ovarian cancer had history of breast cancer in family. Median age of presentation to the hospital was 47 years and median time interval in metachronous disease patients was 5.5 years. Conclusion: About 5% of people who have breast cancer and about 10% of women who have ovarian cancer have HBOC, caused by germline mutation in BRCA1, 2 gene. These individuals have increased risk of developing breast cancer at younger age, TNBC, or developing a second primary in breast or ovary plus an overall risk of breast/ovarian/prostate/pancreatic malignancies in other family members due to inheritable mutation. Identification of BRCA mutation in such individuals can help family members to undergo genetic counseling and follow different screening and prevention guidelines from general population thus reducing the cancer risks.
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Yardley, DA, NW Peacock, JD Hainsworth et III HA Burris. « OT2-01-03 : Eribulin in Women with Locally Advanced Breast Cancer Who Do Not Achieve Pathologic Complete Response (pCR) Following Neoadjuvant Chemotherapy : A Sarah Cannon Research Institute Phase II Trial. » Dans Abstracts : Thirty-Fourth Annual CTRC‐AACR San Antonio Breast Cancer Symposium‐‐ Dec 6‐10, 2011 ; San Antonio, TX. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/0008-5472.sabcs11-ot2-01-03.

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Mansani, Fabio Postiglione, Mariane Marcelino Fernandes, Mario Rodrigues Montemor Netto et Cristiane da Costa Bandeira Abrahão Nimir. « COMPARATIVE ANALYSIS BETWEEN IMMUNOHISTOCHEMISTRY PATHOLOGICAL SUBTYPING AND MAMMAPRINT® GENETIC SIGNATURE IN PATIENTS WITH BREAST CANCER IN BRAZIL : A PILOT STUDY ». Dans Abstracts from the Brazilian Breast Cancer Symposium - BBCS 2021. Mastology, 2021. http://dx.doi.org/10.29289/259453942021v31s2098.

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Introduction: Immunohistochemistry, in breast cancer samples, measures the expression of biomarkers such as estrogen receptor (ER), progesterone receptor (PR), HER2, and Ki67. Using the positivity or negativity of the receptors and the Ki67 value, this method, along with the histological results, allows the doctors to classify the tumors into four types as follows: Luminal A, Luminal B, HER2, and basal/triple negative. Genetic signature is a tool involving in numerous studies in this area; however owing to the difficulty of access to the tests, its usefulness is still limited. MammaPrint® was the first test approved by the Food and Drugs Administration (FDA) in 2007 to measure prognostic value associated with breast cancer recurrence and classify patients with breast cancer into “low risk” or “high risk” of developing metastases within the first 10 years after diagnosis and elucidates the patient’s need for adjuvant chemotherapy. It categorizes tumors into subtypes based on biological homogeneity. This study aims to analyze the concordance between the results of immunohistochemistry pathological subtyping and MammaPrint®, which is accompanied by BluePrint®, for the classification and stratification of luminal breast cancer. Material and Methods: Data were collected from the medical records of 19 patients in the Instituto Sul Paranaense de Oncologia (ISPON) who presented immunohistochemistry and genetic test compatible with luminal tumors. Immunohistochemistry was evaluated through hormone receptors, HER2 and mainly Ki67, as defined by the 2013 St. Gallen guidelines (50% of the sample were centrally assessed). For classification by the genetic test, BluePrint® provided the molecular subtype data and MammaPrint® stratified the risk, establishing Luminal A tumors as low risk and Luminal B as high risk. The concordance between the immunohistochemical classification and the genetic test was evaluated with the nonparametric McNemar-Bowker test. The Ki67 cutoff value predictive for recurrence risk compared with MammaPrint® was accessed by the ROC curve. Results: The results showed that, on one side, only 33.3% of patients classified as Luminal A by immunohistochemistry were also classified by the genetic signature as Luminal A. On the other side, on the tumors classified as Luminal B, 60% presented agreement between the classifications. Overall agreement among the tests was 47.3%. The cutoff value found for Ki67 predictive of tumor recurrence risk was ≤5, with a sensitivity of 100% and a specificity of 33%. The agreement between hormonal receptors and HER2 with BluePrint® was 100%. Conclusion: This study provides preliminary data regarding the prognostic and predictive value of genetic and molecular tests — represented by MammaPrint®/BluePrint® and immunohistochemistry—in a sample of Brazilian population, evidencing a discrepancy between the methods. The cutoff value of Ki67 predictive for recurrence risk remains under discussion, since there is no standardization of its measurement methodology. As a result, new studies could be developed, with larger and multicentric samples.
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