Littérature scientifique sur le sujet « Parkison’s disease »
Créez une référence correcte selon les styles APA, MLA, Chicago, Harvard et plusieurs autres
Consultez les listes thématiques d’articles de revues, de livres, de thèses, de rapports de conférences et d’autres sources académiques sur le sujet « Parkison’s disease ».
À côté de chaque source dans la liste de références il y a un bouton « Ajouter à la bibliographie ». Cliquez sur ce bouton, et nous générerons automatiquement la référence bibliographique pour la source choisie selon votre style de citation préféré : APA, MLA, Harvard, Vancouver, Chicago, etc.
Vous pouvez aussi télécharger le texte intégral de la publication scolaire au format pdf et consulter son résumé en ligne lorsque ces informations sont inclues dans les métadonnées.
Articles de revues sur le sujet "Parkison’s disease"
Burke, Sarah Elizabeth, Immanuel B. H. Samuel, Qing Zhou, Benzi Kluger, Catherine Price et Mingzhou Ding. « 2210 ». Journal of Clinical and Translational Science 1, S1 (septembre 2017) : 59. http://dx.doi.org/10.1017/cts.2017.210.
Texte intégralChuma, Takayo. « Rehabilitation Medicine for Patients with Parkison's Disease ». Japanese Journal of Rehabilitation Medicine 58, no 3 (18 mars 2021) : 303–11. http://dx.doi.org/10.2490/jjrmc.58.303.
Texte intégralChuma, Takayo. « Rehabilitation Medicine for Patients with Parkison's Disease ». Japanese Journal of Rehabilitation Medicine 56, no 3 (18 mars 2019) : 190–94. http://dx.doi.org/10.2490/jjrmc.56.190.
Texte intégralJuncos, Jorge, Lisa Aranitis, Charles Nemeroff, Dennis Sweitzer et Paul Yeung. « QUETIAPINE IMPROVES PSYCHOTIC SYMPTOMS ASSOCIATED WITH PARKISON's DISEASE ». American Journal of Geriatric Psychiatry 7 (septembre 1999) : 45. http://dx.doi.org/10.1097/00019442-199911001-00132.
Texte intégralMarek, Kenneth, Danna Jennings, Gilles Tamagnan et John Seibyl. « Biomarkers for Parkison's disease : Tools to assess Parkinson's disease onset and progression ». Annals of Neurology 64, S2 (6 janvier 2009) : S111—S121. http://dx.doi.org/10.1002/ana.21602.
Texte intégralHagenmüller, F., et M. Classen. « Motility of Oddi's Sphincter in Parkison's Disease, Progressive Systemic Sclerosis, and Achalasia ». Endoscopy 20, S 1 (septembre 1988) : 189–92. http://dx.doi.org/10.1055/s-2007-1018174.
Texte intégralMurdoch, B. « 2.353 TREATMENT OF ARTICULATORY DYSFUNCTION IN PARKISON'S DISEASE USING REPETATIVE TRANSCRANIAL MAGNETIC STIMULATION ». Parkinsonism & ; Related Disorders 18 (janvier 2012) : S154. http://dx.doi.org/10.1016/s1353-8020(11)70675-7.
Texte intégralSiniscalchi, Antonio, Luca Gallelli, Nicola B. Mercuri, Guido Ferreri Ibbadu et Giovambattista De Sarro. « Role of lifestyle factors on plasma homocysteine levels in Parkison's disease patients treated with levodopa ». Nutritional Neuroscience 9, no 1-2 (février 2006) : 11–16. http://dx.doi.org/10.1080/10284150600583446.
Texte intégralKyuhou, Shin-ichi. « Preventive effects of phytoestrogens on the paraquat-induced toxicities in the cellular model of Parkison disease ». Neuroscience Research 58 (janvier 2007) : S234. http://dx.doi.org/10.1016/j.neures.2007.06.545.
Texte intégralŠtuhec, Matej. « Memantine associated with parkisonism in a patient with Alzheimer's disease : A case study and the review of the literature ». Anali PAZU 5, no 1-2 (7 juin 2022) : 6–9. http://dx.doi.org/10.18690/analipazu.5.1-2.6-9.2015.
Texte intégralThèses sur le sujet "Parkison’s disease"
Sharma, Manu. « Genetic epidemilogy of Parkison disease ». [S.l. : s.n.], 2008.
Trouver le texte intégralBindoff, L. A. « Defects of mitochondrial oxidations ». Thesis, University of Newcastle Upon Tyne, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.241373.
Texte intégralMillot, Mathilde. « Implication de la sérotonine dans l'expression de troubles moteurs et neuropsycho-comportementaux dans la maladie de Parkison ». Thesis, Lyon, 2019. http://www.theses.fr/2019LYSE1100.
Texte intégralParkinson’s disease (PD) is characterized by a progressive and irreversible degeneration of dopaminergic (DA) neurons localized in the substantia nigra, leading to a loss of dopamine within the target structures. When the loss of DA reaches 60 to 80 %, PD patients develop a wide range of motor (rigidity, tremor, akinesia fro example) and non-motor (depression, anxiety, apathy for example) symptoms. Dopatherapy allows the reduction of symptoms expression. But some motor and non-motor symptoms are not counteracted by those DA drugs. In addition to DA degeneration, patients present an early serotonergic (5-HT) lesion. This lesion is linked to the severity of some motor and non-motor symptoms. However, there is no causal link established between 5-HT lesion and parkinsonian symptoms. Therefore, it was essential to determine the role of 5-HT 1) in the expression of motor and non-motor symptoms 2) and in the response of DA and 5-HT treatments. For that, we used a new monkey model of PD, exhibiting a 5-HT lesion (with MDMA ‘”ecstasy”)) followed by a DA lesion (with MPTP). This model allowed us to evaluate the impact of an early 5-HT lesion on parkinsonian symptoms. We used different approaches: PET imaging, pharmacology, behavioral and neuroanatomy. The MDMA-driven early 5-HT lesion induced an anxious-like behavior on MDMA treatedmonkeys. This behavioral modification was not counteracted by 5-HT drugs (antidepressant). This MDMA lesion has also increased the severity and the progression of parkinsonian symptoms induced by DA lesion with MPTP
Bellot, Emmanuelle. « Le colliculus supérieur dans la maladie de Parkinson : un biomarqueur possible ? » Thesis, Université Grenoble Alpes (ComUE), 2017. http://www.theses.fr/2017GREAS043/document.
Texte intégralSome visuo-motor impairments observed in the early stages of Parkinson’s disease (PD) might be related to a dysfunction of a subcortical structure connected to the basal ganglia, the superior colliculus (SC). The aim of this PhD thesis was to explore the functional state of the SC in newly diagnosed (de novo) PD patients before and after dopaminergic treatment intake, in order to evaluate the potential value of the SC functioning as a biomarker. To do this, we developed a functional Magnetic Resonance Imaging (fMRI) experimental protocol, which successfully imaged the SC and also the lateral geniculate nucleus (LGN) and primary visual area V1 functional activity and modulate their activity by using visual stimuli with low luminance contrast levels (<10%). Additionally, we estimated the perceptual response to contrast by using a psychophysical task. We tested in a first time this experimental protocol on healthy subjects with varying age in order to evaluate the effect of normal aging on the functioning of these regions of interest (ROIs) and to distinguish the effects related to age from those potentially related to the pathology (Study 1). A significant progressive decrease of the BOLD amplitude with age was observed in the LGN and V1. These data were consistent with the response functions obtained with the psychophysical task. These results indicate a significant luminance contrast sensitivity decline with age of both the magnocellular and parvocellular pathways. In a second time, we tested our protocol on de novo PD patients before and after the introduction of the first dopaminergic treatment in order to assess the effects of PD and treatment on the ROIs functioning (Study 2). Our results highlighted an early alteration of the contrast processing for the SC and LGN in PD patients, with no normalization after dopaminergic treatment introduction. These findings indicate a functional deficit of the SC and LGN that appears early in the disease course, in line with our effective connectivity analyses. These results could favor the identification of deficits linked to sensory dysfunction of these structures as well as the development of paraclinical and clinical tests involving this system for an early diagnosis of the disease
Ouachikh, Omar. « Effets motivationnels des agonistes dopaminergiques dans un modèle de rat ayant une lésion bilatérale de l'aire tegmentale ventrale ». Thesis, Clermont-Ferrand 1, 2013. http://www.theses.fr/2013CLF1MM18.
Texte intégralNéant
Hsu, Shao Hsuan, et 徐紹軒. « Design of health care watch for patients with Parkison’s disease ». Thesis, 2009. http://ndltd.ncl.edu.tw/handle/46597877222652080756.
Texte intégral長庚大學
電機工程學研究所
97
As a result of medicine advances, aging population increases. The need of care in chronic is also increased .To allow limited medical resource can be used effectively, the aim of this study was to establish a long-distance Zigbee wireless network for medical care .Not only elderly but also patients can use it to measure ECG signals and record activity amount at any time at home. For Parkison’s patients, the amount of hand tremor also can be recorded. Therefore, users for the network can be well-cared, and health care providers can have a better health monitoring on the users.
Clemente, Francesca. « Synthesis of alkylated azasugars and their therapeutic potential against lysosomal storage and neurological disorders : the Gaucher-Parkinson case ». Doctoral thesis, 2021. http://hdl.handle.net/2158/1234174.
Texte intégralLI, Yung-Chen, et 李詠甄. « An Analysis of Survial of Parkison’s Disease and Its Complicated Dementia : A 10-Year Population-Based Study ». Thesis, 2017. http://ndltd.ncl.edu.tw/handle/51560206833873069175.
Texte intégral國立臺北護理健康大學
健康事業管理研究所
105
Background and Objective Parkinson's disease is the secondary illness among neurodegenerative diseases, however, its causes are still unclear. Besides, the past studies have shown that those who suffer from Parkinson's disease will face higher mortality rate than others. Thus, the survival factors which affect the Parkinson disease are taken more seriously. In addition to a higher risk of death, most patients would confront the complication of dementia. While, only few studies explore the hypothesis whether the risk of death is higher in Parkinson’s disease patients with dementia than those who don’t have this complication. To supplement the insufficiency, this study, aims to compare the Parkinson's disease patients with non-Parkinson's disease patients using the National Health Insurance Research Database in terms of the risk of death and make a contrast between the survival of Parkinson’s disease patients and Parkinson’s disease patients with dementia. Methods We conducted a retrospective cohort study to evaluate the Parkinson’s disease patients, non-Parkinson's disease patients, and Parkinson's disease patients with dementia in 2002. Then, we observed the survival status after controlling the demographic variables. Based on the data extracted from the National Health Insurance Research Database from 1999 to 2012, we identified 3,091 Parkinson’s disease cases and matched “gender” and “age” to select 12,104 of non-Parkinson’s disease cases. Also, we used Cox proportional hazard model to analyze (1) the survival status of Parkinson’s disease patients and non-Parkinson's disease patients (2) the survival status of Parkinson's disease patients and Parkinson’s disease patients with dementia. Results After controlling the variables of gender, age, Charlson Comorbidity Index (CCI) and urbanization level, we find that the mortality risk of Parkinson's disease is higher than non-Parkinson's disease, while the adjusted hazard ratio was 1.37 (adjusted HR = 1.37, 95% CI = 1.24-1.50); females have lower mortality risk than males, while the adjusted hazard ratio was 38% (adjusted HR = 0.62, 95% CI = 0.53-0.74); and the patients age ≥ 65 have higher mortality risk than < 65, while the adjusted hazard ratio was 3.00 (adjusted HR = 3.00, 95% CI = 2.27-3.97); CCI score 2 has higher mortality risk than CCI score 0, while the adjusted hazard ratio was 1.45 (adjusted HR = 1.45, 95% CI = 1.07-1.96). Under the controlled variables of gender, age and CCI, the data shows that those patients who suffer from dementia confronted higher mortality risk than non-dementia patients, while the adjusted hazard ratio was 1.11 (adjusted HR = 1.11, 95% CI = 0.98-1.26). Conclusion and Suggestion We observed that Parkinson's disease patients and Parkinson's disease patients with dementia show a higher mortality risk. The study results can help patients to obtain earlier intervention services and appropriate treatment according to their needs in a different phase of disease. In this way, it can slow down the occurrence of Parkinson's disease patients with disability. In addition, we expect the results can provide reference for future assessment and health care policy and also help clinical practitioners to get further assistance of guidelines for death risk assessment of Parkinson's disease.
Santos, Diliana Maria Barradas Rebelo dos. « Molecular and Functional Covariance Statistics demonstrate Network Reorganization in Parkison's Disease : a multimodal PET-fMRI study ». Master's thesis, 2020. http://hdl.handle.net/10316/97899.
Texte intégralA Doença de Parkinson (DP) é uma doença neurodegenerativa caracterizada por sintomas motores e não-motores relacionados com a perda de neurónios dopaminérgicos na substantia nigra pars compacta. Sabe-se que este desiquilíbrio afecta vários circuitos, entre os quais, o sistema oculomotor. Trabalhos anteriores demonstraram que e como a resposta hemodinâmica é afectada neste sistema e, de um modo independente, como é o seu padrão molecular. Neste trabalho, foi averiguado se existe e qual a correlação entre padrão hemodinâmico e libertação dopaminérgica, em áreas definidas. Para tal, foram recrutados participantes controlos e com DP, estes últimos com e sem medicação e, com recurso a um paradigma block-design com 2 runs (prosacadas e antisacadas, com sacadas verticais e horizontais), foram identificadas e localizadas as áreas cerebrais de interesse, de modo a estudar a relação entre o metabolismo molecular em repouso (por tomografia de emissão de positrões, PET, usando o composto sintético Raclopride, como antagonista selectivo dos receptores D2) em áreas diferentes e entre o metabolismo molecular basal e a actividade funcional (pela ressonância magnética funcional, fMRI).Esta abordagem ROI-based foi cingida a áreas encontradas funcionalmente e de acordo com a literatura (frontal eye field, parietal eye field) e segmentadas manualmente (caudado e putamen, bilateralmente). O estudo de covariâncias mostrou que, relativamente a análise unimodal (molecular), nas prossacadas, há um domínio frontal nos controlos enquanto que, nos doentes, o predomínio é parietal (ambos para caudado e/ou putamen). No que toca a antissacadas, esta conectividade estriado-cortical salienta novamente o parietal eye field como protagonista de relevo, nos doentes e nos controlos. Relativamente a análise de covariância multimodal, o grupo de doentes mostrou uma associação funcional-molecular negativa de região frontal com o putamen ao contrário da associação postiva observada no grupo controlo. A análise de follow-up demonstrou que, no subgrupo de doentes não medicados, a associação bimodal negativa entre região frontal e estriado foi verificada, concluindo que a reorganização do circuito não depende da medicação. Face aos resultados obtidos, podemos concluir que este trabalho complementa e alarga conhecimento acerca da reorganização compensatória da conectividade molecular e funcional na Doença de Parkinson.
The use of covariance statistics based on PET imaging data represents a recent approach to study the organization of brain networks. We adopted this framework and combined PET/fMRIto investigate reorganization of dopaminergic networks and their relation with functional activation plasticity. We performed molecular imaging of dopamine D2 receptors (using 11C-Raclopride) and fMRI of the oculomotor system, including the network linking striatal regions, frontal and parietal eye fields. Our block-design included prosaccades and antisaccades, allowing to identify Frontal eye field/Parietal eye field. We measured distribution volume ratio quantitative measures of D2-receptor binding and brain activity in fourteen Parkinson’s disease patients (ON/OFF subgroups) and nine healthy controls. We tested the hypothesis whether multimodal covariance statistics reflect network reorganization in Parkinson’s disease. Concerning unimodal molecular distribution volume ratio covariance across regions defined by prosaccades, we found striking striato-cortical shifts: connectivity dominated for frontal eye field in the control group while parietal eye field dominated in PD group (both for caudate/putamen).Concerning antisaccades, parietal eye field-caudate/putamen striatal-cortical connectivity dominated in Parkinson’s disease patients (only the putamen in controls). Concerning multimodal covariance statistics, a striking sign-reversal was observed: Parkinson’s disease patients showed negative frontal eye field-putamen functional-molecular associations in contrast with the positive correlations observed in controls. Follow-up analysis in off-medication Parkinson’s disease patients confirmed a negative functional-molecular correlation concerning frontal eye field and distribution volume ratio in both putamen/caudate, and vertical/horizontal prosaccades, respectively.These results provide a multimodal functional-molecular imaging correlate of network reorganization in Parkinson’s disease. It is consistent with compensatory brain activity increases/decreases in parietal eye field/frontal eye field, and the novel observation of specific disease-related negative covariance of D2 receptor and brain activity levels.
Outro - FTC - Portuguese national funding agency for science, UID/4950/2017– COMPETE, FEDER, PAC/MEDPERSYST-16428, BIGDATIMAGE, CENTRO-01-0145-FEDER-000016 financed by Centro 2020 FEDER, COMPETE
Santos, Diliana Maria Barradas Rebelo dos. « Molecular and Functional Covariance Statistics demonstrate Network Reorganization in Parkison's Disease : a multimodal PET-fMRI study ». Master's thesis, 2020. http://hdl.handle.net/10316/97887.
Texte intégralA Doença de Parkinson (DP) é uma doença neurodegenerativa caracterizada por sintomas motores e não-motores relacionados com a perda de neurónios dopaminérgicos na substantia nigra pars compacta. Sabe-se que este desiquilíbrio afecta vários circuitos, entre os quais, o sistema oculomotor. Trabalhos anteriores demonstraram que e como a resposta hemodinâmica é afectada neste sistema e, de um modo independente, como é o seu padrão molecular. Neste trabalho, foi averiguado se existe e qual a correlação entre padrão hemodinâmico e libertação dopaminérgica, em áreas definidas. Para tal, foram recrutados participantes controlos e com DP, estes últimos com e sem medicação e, com recurso a um paradigma block-design com 2 runs (prosacadas e antisacadas, com sacadas verticais e horizontais), foram identificadas e localizadas as áreas cerebrais de interesse, de modo a estudar a relação entre o metabolismo molecular em repouso (por tomografia de emissão de positrões, PET, usando o composto sintético Raclopride, como antagonista selectivo dos receptores D2) em áreas diferentes e entre o metabolismo molecular basal e a actividade funcional (pela ressonância magnética funcional, fMRI).Esta abordagem ROI-based foi cingida a áreas encontradas funcionalmente e de acordo com a literatura (frontal eye field, parietal eye field) e segmentadas manualmente (caudado e putamen, bilateralmente). O estudo de covariâncias mostrou que, relativamente a análise unimodal (molecular), nas prossacadas, há um domínio frontal nos controlos enquanto que, nos doentes, o predomínio é parietal (ambos para caudado e/ou putamen). No que toca a antissacadas, esta conectividade estriado-cortical salienta novamente o parietal eye field como protagonista de relevo, nos doentes e nos controlos. Relativamente a análise de covariância multimodal, o grupo de doentes mostrou uma associação funcional-molecular negativa de região frontal com o putamen ao contrário da associação postiva observada no grupo controlo. A análise de follow-up demonstrou que, no subgrupo de doentes não medicados, a associação bimodal negativa entre região frontal e estriado foi verificada, concluindo que a reorganização do circuito não depende da medicação. Face aos resultados obtidos, podemos concluir que este trabalho complementa e alarga conhecimento acerca da reorganização compensatória da conectividade molecular e funcional na Doença de Parkinson.
The use of covariance statistics based on PET imaging data represents a recent approach to study the organization of brain networks. We adopted this framework and combined PET/fMRIto investigate reorganization of dopaminergic networks and their relation with functional activation plasticity. We performed molecular imaging of dopamine D2 receptors (using 11C-Raclopride) and fMRI of the oculomotor system, including the network linking striatal regions, frontal and parietal eye fields. Our block-design included prosaccades and antisaccades, allowing to identify Frontal eye field/Parietal eye field. We measured distribution volume ratio quantitative measures of D2-receptor binding and brain activity in fourteen Parkinson’s disease patients (ON/OFF subgroups) and nine healthy controls. We tested the hypothesis whether multimodal covariance statistics reflect network reorganization in Parkinson’s disease. Concerning unimodal molecular distribution volume ratio covariance across regions defined by prosaccades, we found striking striato-cortical shifts: connectivity dominated for frontal eye field in the control group while parietal eye field dominated in PD group (both for caudate/putamen).Concerning antisaccades, parietal eye field-caudate/putamen striatal-cortical connectivity dominated in Parkinson’s disease patients (only the putamen in controls). Concerning multimodal covariance statistics, a striking sign-reversal was observed: Parkinson’s disease patients showed negative frontal eye field-putamen functional-molecular associations in contrast with the positive correlations observed in controls. Follow-up analysis in off-medication Parkinson’s disease patients confirmed a negative functional-molecular correlation concerning frontal eye field and distribution volume ratio in both putamen/caudate, and vertical/horizontal prosaccades, respectively.These results provide a multimodal functional-molecular imaging correlate of network reorganization in Parkinson’s disease. It is consistent with compensatory brain activity increases/decreases in parietal eye field/frontal eye field, and the novel observation of specific disease-related negative covariance of D2 receptor and brain activity levels.
Outro - FTC - Portuguese national funding agency for science, UID/4950/2017– COMPETE, FEDER, PAC/MEDPERSYST-16428, BIGDATIMAGE, CENTRO-01-0145-FEDER-000016 financed by Centro 2020 FEDER, COMPETE
Livres sur le sujet "Parkison’s disease"
Lauren, Taryn. Parkison Disease Nock Down ! : How to Treat Parkison Disease Without Pills. Independently Published, 2022.
Trouver le texte intégralActes de conférences sur le sujet "Parkison’s disease"
Melo, Yuri Sena, Wesley Anderson de Souza Miranda, João Lucas De Morais Bezerra et Thaís Bel de Oliveira Teixeira. « The effects of virtual reality on functional capacity at different stages of Parkison’s disease ». Dans XIII Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1516-3180.466.
Texte intégralMoro-Velazquez, L., J. A. Gomez-Garcia, J. I. Godino-Llorente, J. Rusz, S. Skodda, F. Grandas, J. M. Velazquez, J. R. Orozco-Arroyave, E. Noth et N. Dehak. « Study of the Automatic Detection of Parkison’s Disease Based on Speaker Recognition Technologies and Allophonic Distillation ». Dans 2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). IEEE, 2018. http://dx.doi.org/10.1109/embc.2018.8512562.
Texte intégral