Bibliographies thématiques / Pa4409

Littérature scientifique sur le sujet « Pa4409 »

Auteur : Grafiati
Publié le 27 juillet 2024
Mis à jour le 29 juillet 2024

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Articles de revues sur le sujet "Pa4409"

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Vercammen, Ken, Qing Wei, Daniel Charlier, Andreas Dötsch, Susanne Haüssler, Sebastian Schulz, Francesca Salvi et al. « Pseudomonas aeruginosa LysR PA4203 Regulator NmoR Acts as a Repressor of the PA4202nmoAGene, Encoding a Nitronate Monooxygenase ». Journal of Bacteriology 197, no 6 (10 novembre 2014) : 1026–39. http://dx.doi.org/10.1128/jb.01991-14.

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The PA4203 gene encodes a LysR regulator and lies between theppgLgene (PA4204), which encodes a periplasmic gluconolactonase, and, in the opposite orientation, the PA4202 (nmoA) gene, coding for a nitronate monooxygenase, andddlA(PA4201), encoding ad-alanine alanine ligase. The intergenic regions between PA4203 andppgLand between PA4203 andnmoAare very short (79 and 107 nucleotides, respectively). Here we show that PA4203 (nmoR) represses its own transcription and the expression ofnmoA. A chromatin immunoprecipitation analysis showed the presence of a single NmoR binding site betweennmoAandnmoR, which was confirmed by electrophoretic mobility shift assays (EMSAs) with the purified NmoR protein. Despite this observation, a transcriptome analysis revealed more genes to be affected in annmoRmutant, including genes known to be part of the MexT LysR activator regulon. The PA1225 gene, encoding a quinone oxidoreductase, was the most highly upregulated gene in thenmoRdeletion mutant, independently of MexT. Finally, deletion of thenmoAgene resulted in an increased sensitivity of the cells to 3-nitropropionic acid (3-NPA), confirming the role of the nitronate monooxygenase protein in the detoxification of nitronate.
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Shen, Lixin, Lang Gao, Mengjiao Yang, Jian Zhang, Yulu Wang, Yuqi Feng, Liping Wang et Shiwei Wang. « Deletion of the PA4427-PA4431 Operon of Pseudomonas aeruginosa PAO1 Increased Antibiotics Resistance and Reduced Virulence and Pathogenicity by Affecting Quorum Sensing and Iron Uptake ». Microorganisms 9, no 5 (14 mai 2021) : 1065. http://dx.doi.org/10.3390/microorganisms9051065.

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The respiratory chain is very important for bacterial survival and pathogenicity, yet the roles of the respiratory chain in P. aeruginosa remain to be fully elucidated. Here, we not only proved experimentally that the operon PA4427-PA4431 of Pseudomonas aeruginosa PAO1 encodes respiratory chain complex III (cytobc1), but also found that it played important roles in virulence and pathogenicity. PA4429–31 deletion reduced the production of the virulence factors, including pyocyanin, rhamnolipids, elastase, and extracellular polysaccharides, and it resulted in a remarkable decrease in pathogenicity, as demonstrated in the cabbage and Drosophila melanogaster infection models. Furthermore, RNA-seq analysis showed that PA4429–31 deletion affected the expression levels of the genes related to quorum-sensing systems and the transport of iron ions, and the iron content was also reduced in the mutant strain. Taken together, we comprehensively illustrated the function of the operon PA4427–31 and its application potential as a treatment target in P. aeruginosa infection.
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Wiegand, Irith, Alexandra K. Marr, Elena B. M. Breidenstein, Kristen N. Schurek, Patrick Taylor et Robert E. W. Hancock. « Mutator Genes Giving Rise to Decreased Antibiotic Susceptibility in Pseudomonas aeruginosa ». Antimicrobial Agents and Chemotherapy 52, no 10 (28 juillet 2008) : 3810–13. http://dx.doi.org/10.1128/aac.00233-08.

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ABSTRACT Screening of the PA14 genomic transposon mutant library for resistance to ceftazidime, tobramycin, and ciprofloxacin led to the discovery of several mutants that appeared in more than one screen. Testing of the frequency of mutation to ciprofloxacin resistance revealed previously known mutator genes, including mutS and mutL, as well as mutators that have not yet been described for P. aeruginosa, including PA3958 and RadA (PA4609).
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Otaegi, Itziar, Nora Aramburu, Alejandro Müller et Gonzalo Guerrica-Echevarría. « Novel Biobased Polyamide 410/Polyamide 6/CNT Nanocomposites ». Polymers 10, no 9 (4 septembre 2018) : 986. http://dx.doi.org/10.3390/polym10090986.

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Biobased polyamide 410 (PA410)/multiwall carbon nanotube (CNT) nanocomposites (NCs) were obtained by melt-mixing in a twin screw extruder a Polyamide 6 (PA6)-based masterbatch (with 15 wt % CNT content) with neat PA410. Directly mixed PA410/CNT NCs were also obtained for comparison purposes. Transmision Electronic Microscopy (TEM) observation and conductivity measurements demonstrated that a good dispersion of CNTs was obtained, which was probably induced by the full miscibility between PA410 and PA6 (in the concentration range employed here), as ascertained by Differential Scanning Calorimetry (DSC) tests. As a result, the PA410/PA6/CNT NCs showed superior mechanical behaviour (≈10% Young’s modulus increase with a 4 wt % CNT content) than the binary PA410/CNT NCs (≈5% Young’s modulus increase with a 6 wt % CNT content), as well as superior electrical behaviour, with maximum conductivity values of approximately three orders of magnitude higher than in the binary PA410/CNT system, and lower percolation threshold values (0.65 wt % CNT content vs. 3.98 wt % CNT). The good dispersion and enhanced mechanical and electrical properties of these novel biobased nanocomposites, broadens their potential applications, such as electrical and electronics (E&E) or automotive industries.
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Southey-Pillig, Christopher J., David G. Davies et Karin Sauer. « Characterization of Temporal Protein Production in Pseudomonas aeruginosa Biofilms ». Journal of Bacteriology 187, no 23 (1 décembre 2005) : 8114–26. http://dx.doi.org/10.1128/jb.187.23.8114-8126.2005.

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ABSTRACT Phenotypic and genetic evidence supporting the notion of biofilm formation as a developmental process is growing. In the present work, we provide additional support for this hypothesis by identifying the onset of accumulation of biofilm-stage specific proteins during Pseudomonas aeruginosa biofilm maturation and by tracking the abundance of these proteins in planktonic and three biofilm developmental stages. The onset of protein production was found to correlate with the progression of biofilms in developmental stages. Protein identification revealed that proteins with similar function grouped within similar protein abundance patterns. Metabolic and housekeeping proteins were found to group within a pattern separate from virulence, antibiotic resistance, and quorum-sensing-related proteins. The latter were produced in a progressive manner, indicating that attendant features that are characteristic of biofilms such as antibiotic resistance and virulence may be part of the biofilm developmental process. Mutations in genes for selected proteins from several protein production patterns were made, and the impact of these mutations on biofilm development was evaluated. The proteins cytochrome c oxidase, a probable chemotaxis transducer, a two-component response regulator, and MexH were produced only in mature and late-stage biofilms. Mutations in the genes encoding these proteins did not confer defects in growth, initial attachment, early biofilm formation, or twitching motility but were observed to arrest biofilm development at the stage of cell cluster formation we call the maturation-1 stage. The results indicated that expression of theses genes was required for the progression of biofilms into three-dimensional structures on abiotic surfaces and the completion of the biofilm developmental cycle. Reverse transcription-PCR analysis confirmed the detectable change in expression of the respective genes ccoO, PA4101, and PA4208. We propose a possible mechanism for the role of these biofilm-specific proteins in biofilm formation.
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Otaegi, Itziar, Nora Aranburu et Gonzalo Guerrica-Echevarría. « Attaining Toughness and Reduced Electrical Percolation Thresholds in Bio-Based PA410 by Combined Addition of Bio-Based Thermoplastic Elastomers and CNTs ». Polymers 13, no 19 (5 octobre 2021) : 3420. http://dx.doi.org/10.3390/polym13193420.

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Multi-walled carbon nanotubes (CNTs) were added to provide electrical conductivity to bio-based polymer blends with improved toughness (based on commercially available Pebax thermoplastic elastomers and bio-based polyamide 4,10). A preliminary study including three different Pebax grades was carried out to select the grade and the composition that would best improve the impact properties of PA410. Thus, tough multiphasic PA/Pebax/CNT nanocomposites (NCs) with enhanced electrical conductivity were obtained. The CNTs were added either: (1) in the form of pristine nanotubes or (2) in the form of a PA6-based masterbatch. Hence, PA410/Pebax/CNT ternary NCs and PA410/PA6/Pebax/CNT quaternary NCs were obtained, respectively, up to a CNT content of 1 wt%. The ternary and quaternary NCs both showed similar mechanical and electrical properties. The electrical percolation threshold decreased with respect to previously studied corresponding NCs without Pebax, i.e., PA410/CNT and PA410/PA6/CNT, due to the partial volume exclusion effect of Pebax over the CNTs that were dispersed mainly in the PA matrix; materials with percolation concentrations as low as 0.38 wt% were obtained. With respect to mechanical properties, contrary to the NCs without Pebax, all the PA/Pebax/CNT NCs showed a ductile behavior and impact strength values that were from three to five-fold higher than that of the pure PA410.
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Weaver, Valerie B., et Roberto Kolter. « Burkholderia spp. Alter Pseudomonas aeruginosa Physiology through Iron Sequestration ». Journal of Bacteriology 186, no 8 (15 avril 2004) : 2376–84. http://dx.doi.org/10.1128/jb.186.8.2376-2384.2004.

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ABSTRACT Pseudomonas aeruginosa and members of the Burkholderia cepacia complex often coexist in both the soil and the lungs of cystic fibrosis patients. To gain an understanding of how these different species affect each other's physiology when coexisting, we performed a screen to identify P. aeruginosa genes that are induced in the presence of Burkholderia. A random gene fusion library was constructed in P. aeruginosa PA14 by using a transposon containing a promoterless lacZ gene. Fusion strains were screened for their ability to be induced in the presence of Burkholderia strains in a cross-streak assay. Three fusion strains were induced specifically by Burkholderia species; all three had transposon insertions in genes known to be iron regulated. One of these fusion strains, containing a transposon insertion in gene PA4467, was used to characterize the inducing activity from Burkholderia. Biochemical and genetic evidence demonstrate that ornibactin, a siderophore produced by nearly all B. cepacia strains, can induce P. aeruginosa PA4467. Significantly, PA4467 is induced early in coculture with an ornibactin-producing but not an ornibactin-deficient B. cepacia strain, indicating that ornibactin can be produced by B. cepacia and detected by P. aeruginosa when the two species coexist.
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Chen, Lin, et Kangmin Duan. « A PhoPQ-Regulated ABC Transporter System Exports Tetracycline in Pseudomonas aeruginosa ». Antimicrobial Agents and Chemotherapy 60, no 5 (7 mars 2016) : 3016–24. http://dx.doi.org/10.1128/aac.02986-15.

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ABSTRACTPseudomonas aeruginosais an important human pathogen whose infections are difficult to treat due to its high intrinsic resistance to many antibiotics. Here, we show that the disruption of PA4456, encoding the ATP binding component of a putative ATP-binding cassette (ABC) transporter, increased the bacterium's susceptible to tetracycline and other antibiotics or toxic chemicals. Fluorescence spectroscopy and antibiotic accumulation tests showed that the interruption of the ABC transporter caused increased intracellular accumulation of tetracycline, demonstrating a role of the ABC transporter in tetracycline expulsion. Site-directed mutagenesis proved that the conserved residues of E170 in the Walker B motif and H203 in the H-loop, which are important for ATP hydrolysis, were essential for the function of PA4456. Through a genome-wide search, the PhoPQ two-component system was identified as a regulator of the computationally predicted PA4456-4452 operon that encodes the ABC transporter system. A >5-fold increase of the expression of this operon was observed in thephoQmutant. The results obtained also show that the expression of thephzA1B1C1D1E1operon and the production of pyocyanin were significantly higher in the ABC transporter mutant, signifying a connection between the ABC transporter and pyocyanin production. These results indicated that the PhoPQ-regulated ABC transporter is associated with intrinsic resistance to antibiotics and other adverse compounds inP. aeruginosa, probably by extruding them out of the cell.
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Otaegi, Itziar, Nora Aranburu, Maider Iturrondobeitia, Julen Ibarretxe et Gonzalo Guerrica-Echevarría. « The Effect of the Preparation Method and the Dispersion and Aspect Ratio of CNTs on the Mechanical and Electrical Properties of Bio-Based Polyamide-4,10/CNT Nanocomposites ». Polymers 11, no 12 (11 décembre 2019) : 2059. http://dx.doi.org/10.3390/polym11122059.

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Bio-based polymeric nanocomposites (NCs) with enhanced electrical conductivity and rigidity were obtained by adding multi-walled carbon nanotubes (CNTs) to a commercial bio-based polyamide 4,10 (PA410). Two different types of commercial CNTs (Cheap Tubes and Nanocyl NC7000TM) and two different preparation methods (using CNTs in powder form and a PA6-based masterbatch, respectively) were used to obtain melt-mixed PA410/CNT NCs. The effect of the preparation method as well as the degree of dispersion and aspect ratio of the CNTs on the electrical and mechanical properties of the processed NCs was studied. Superior electrical and mechanical behavior was observed in the Nanocyl CNTs-based NCs due to the enhanced dispersion and higher aspect ratio of the nanotubes. A much more significant reduction in aspect ratio was observed in the Cheap Tubes CNTs than in the Nanocyl CNTs. This was attributed to the fact that the shear stress applied during melt processing reduced the length of the CNTs to similar lengths in all cases, which pointed to the diameter of the CNTs as the key factor determing the properties of the NCs. The PA6 in the ternary PA410/PA6/CNT system led to improved Young’s modulus values because the reinforcing effect of CNTs was greater in PA6 than in PA410.
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HAYASHI, FUMIAKI, KAZUO NAGASHIMA, YOSHIHIRO TERUI, YOSHIMI KAWAMURA, KOICHI MATSUMOTO et HIROSHI ITAZAKI. « The structure of PA48009 : The revised structure of duramycin. » Journal of Antibiotics 43, no 11 (1990) : 1421–30. http://dx.doi.org/10.7164/antibiotics.43.1421.

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Thèses sur le sujet "Pa4409"

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Joyal, Mark A. J. « The Platonic 'Theages' : an introduction, commentary and critical edition ». Thesis, University of St Andrews, 1988. http://hdl.handle.net/10023/15486.

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The Theages poses a number of problems for the interpreter of Plato and the Platonic dialogue. Traditionally, the most controversial one concerns the authenticity of the work: is Plato its author, and what criteria may be considered valid and important for settling the debate over authorship. But there are numerous other questions of at least equal significance. What is the purpose for which this dialogue was written, and what is its meaning. Is it merely a patchwork, as is commonly assumed, or does it display a structural unity. How does the Socrates of this work compare with the same character in other Socratic compositions, and what literary qualities can be attributed to the author's portrayal of the dialogue's other personae. How are we to evaluate the lengthy section in the Theages on Socrates' "divine sign". When was this dialogue written. What is its relation to the other works in the Platonic Corpus, to Socratic literature generally, and to philosophical interests at the time of its composition. The introduction and some of the appendices to this thesis attempt to offer answers to these questions, both through a comprehensive review and assessment of the critical literature on the Theages, and through the use of new evidence, argumentation, and interpretation. At the same time, a basis for the analyses offered here (and for future examinations of the Theages) is provided in this study by a detailed line-by-line commentary on the text. The text on which this commentary depends has been established from a fresh collation of all known manuscripts, early printed editions, and ancient testimonia, containing all or part of the Theages. This thesis represents the first attempt, in any language, to undertake the above programme of work on a definitive scale.
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Moore, Kenneth R. « Sex and society in the 'Laws' of Plato ». Thesis, University of St Andrews, 2003. http://hdl.handle.net/10023/14535.

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This thesis deals with the topics of sex and society in the Laws of Plato with recourse to ancient historical context and modern critical theory. It examines reconstructions of ancient 'sexuality' (e.g. through Dover, Foucault and Davidson) with a view to increased clarification. The text of the Laws is considered, along with many of its literary qualities, its influences and the utopian plan that it entails. Plato's narrator, the Athenian Stranger, has proposed the remarkable theory that sexuality can be controlled through the manipulation of people's thoughts. The thesis is particularly interested in the manner in which sexuality is ideologically constructed. A significant portion of this inquiry deals with education in the hypothetical polis (Magnesia) and the part that this is designed to play specifically in terms of sex-role stereotyping. The Laws spins andreia as the ideal model for the Magnesians to imitate in their mandatory pursuit of arete. The reformulation of the Magnesian oikos and the 'brave new femininity' that this plan entails figure prominently into this examination. Magnesian women must become more like (idealised) men in terms of 'manly' enkrateia. They will combine alleged elements from athenian, Spartan, Kretan, Sauromatian and Amazonian women (plus Platonic philosophy) to attain this new status. Men must become less like women are perceived to be. A law is drafted to ban same-sex activities, considered 'womanish', but there is some uncertainty as to whether or not it will ever be enforced. Psychology and propaganda, religion, education, the family and government will all work together to affect the moral hygiene of Magnesia. The thesis investigates each of these topics, with recourse to material outside the Laws, in considering Plato's social/sexual construction theory.
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Livres sur le sujet "Pa4409"

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Plato. Alcibiade. Paris : Flammarion, 1999.

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Plato. Alcibiades I & II. Fairfield : 1st World Library, 2006.

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Plato. Alcibiades. Cambridge, England : Cambridge University Press, 2001.

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Sophocles. Sophoclis fabulae. Oxonii (Oxford) : e typographeo Clarendoniano, 1990.

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Sophocles. Trachiniae. Oxford : Clarendon Press, 1991.

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Sophocles. Sophoclis Trachiniae. 3e éd. Stutgardiae : Teubner, 1996.

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L, Hunter R., dir. A selection. Cambridge [England] : Cambridge University Press, 1999.

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Sappho. Poems and Fragments. Indianapolis : Hackett, 2002.

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Sappho. Poems & fragments. Newcastle upon Tyne : Bloodaxe Books, 1992.

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Thucydides, dir. The Peloponnesian War. Cambridge [England] : Cambridge University Press, 1989.

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Chapitres de livres sur le sujet "Pa4409"

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Parasram, Ajay. « Sovereignty Beyond Eurocentricity ». Dans Showing Theory to Know Theory : Understanding social science concepts through illustrative vignettes. Showing Theory Press, 2022. http://dx.doi.org/10.22215/stkt/pa44.

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Actes de conférences sur le sujet "Pa4409"

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Klingel, Michelle, Sarah Isaac, Lena Raaijmakers, Renee Jensen, Sanja Stanojevic et Felix Ratjen. « O2concentration based definition of wait times between multiple breath nitrogen washout trials ». Dans ERS International Congress 2016 abstracts. European Respiratory Society, 2016. http://dx.doi.org/10.1183/13993003.congress-2016.pa4409.

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Debnath, Smriti, Prasun Haldar, Santi Gopal Maity, Ritabrata Mitra, Moumita Biswas, Soumya Bhattacharjee, Sujoy Saha et al. « Environmental factors in asthma and allergic diseases among the Indian adolescents : PERFORMANCE study results ». Dans ERS International Congress 2019 abstracts. European Respiratory Society, 2019. http://dx.doi.org/10.1183/13993003.congress-2019.pa4409.

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Wand, Ori, Elad Guber, Alexander Guber, Gali Epstein-Shochet, Lilach Israeli-Shani et David Shitrit. « Inhalations of Tranexamic Acid for hemoptysis : A randomized controlled trial ». Dans ERS International Congress 2018 abstracts. European Respiratory Society, 2018. http://dx.doi.org/10.1183/13993003.congress-2018.pa4409.

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Xue, Yishu, Yilin Pan, Lei Zhao, Huijuan Hao, Min Zhang et Wuping Bao. « NLRP3 affects airway responsiveness in an OVA and ozone-induced asthma model with neutrophil infiltration through regulation of IL-1β ». Dans ERS International Congress 2023 abstracts. European Respiratory Society, 2023. http://dx.doi.org/10.1183/13993003.congress-2023.pa4409.

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« Abstract presentation PA4472 ». Dans ERS International Congress 2019 abstracts. European Respiratory Society, 2019. http://dx.doi.org/10.1183/13993003.congress-2019.pa4472.

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Welsner, Matthias, et Sven Stieglitz. « Correlation between Lung Clearance Index (LCI) with SF6 and single breath diffusing capacity testing in elderly patients ». Dans ERS International Congress 2017 abstracts. European Respiratory Society, 2017. http://dx.doi.org/10.1183/1393003.congress-2017.pa4009.

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Hodgekiss, Claire, Hasan Arshad, Graham Roberts, John Holloway, Elinor Jenkins et Ramesh Kurukulaaratchy. « Atopic Sensitisation of the Isle of Wight Birth Cohort at 26 Years ». Dans ERS International Congress 2017 abstracts. European Respiratory Society, 2017. http://dx.doi.org/10.1183/1393003.congress-2017.pa4049.

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Conan, Pierre Louis, France Charton, Hervé Le Floch, Olivier Bylicki, Wanda Gaspard, Jacques Margery, Frederic Riviere et Charles Soler. « Investigation of factors associated with result of pneumococcal urinary antigen in the microbiological investigation of pneumococcal lower respiratory infections ». Dans ERS International Congress 2017 abstracts. European Respiratory Society, 2017. http://dx.doi.org/10.1183/1393003.congress-2017.pa4109.

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Kwiecien, Iwona, Marek Radkowski, Malgorzata Polubiec-Kownacka, Dariusz Dziedzic, Joanna Domagała-Kulawik et Tomasz Kryczka. « Cytokine profile in lung cancer microenvironment- analysis of bronchoalveolar lavage fluid by Luminex assay ». Dans ERS International Congress 2017 abstracts. European Respiratory Society, 2017. http://dx.doi.org/10.1183/1393003.congress-2017.pa4209.

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Esteves Simões Brandão, Maria, Mariana Rocha, Luísa Nascimento, Teresa Gomes, Joelma Silva, Bebiana Conde et Ana Fernandes. « Malignant pleural mesothelioma:a 16-year, single centre experience ». Dans ERS International Congress 2017 abstracts. European Respiratory Society, 2017. http://dx.doi.org/10.1183/1393003.congress-2017.pa4309.

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