Littérature scientifique sur le sujet « Organotropisme »
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Articles de revues sur le sujet "Organotropisme"
Wei, Shi, et Gene P. Siegal. « Metastatic Organotropism ». Advances In Anatomic Pathology 24, no 2 (mars 2017) : 78–81. http://dx.doi.org/10.1097/pap.0000000000000140.
Texte intégralYuzhalin, Arseniy E., et Dihua Yu. « Brain Metastasis Organotropism ». Cold Spring Harbor Perspectives in Medicine 10, no 5 (23 septembre 2019) : a037242. http://dx.doi.org/10.1101/cshperspect.a037242.
Texte intégralLu, Xin, et Yibin Kang. « Organotropism of Breast Cancer Metastasis ». Journal of Mammary Gland Biology and Neoplasia 12, no 2-3 (14 juin 2007) : 153–62. http://dx.doi.org/10.1007/s10911-007-9047-3.
Texte intégralFu, Hongmei, Eleanor Jayne Ward et Federica M. Marelli-Berg. « Mechanisms of T cell organotropism ». Cellular and Molecular Life Sciences 73, no 16 (1 avril 2016) : 3009–33. http://dx.doi.org/10.1007/s00018-016-2211-4.
Texte intégralGao, Yang, Igor Bado, Hai Wang, Weijie Zhang, Jeffrey M. Rosen et Xiang H. F. Zhang. « Metastasis Organotropism : Redefining the Congenial Soil ». Developmental Cell 49, no 3 (mai 2019) : 375–91. http://dx.doi.org/10.1016/j.devcel.2019.04.012.
Texte intégralKeller, Georg v. « Chelidonium und die Organotropie ». Allgemeine Homöopathische Zeitung 224, no 06 (10 avril 2007) : 217–27. http://dx.doi.org/10.1055/s-2006-935880.
Texte intégralSchmeer, Ernst H. « Rademacher und die Organotropie ». Allgemeine Homöopathische Zeitung 225, no 03 (10 avril 2007) : 115–19. http://dx.doi.org/10.1055/s-2006-935894.
Texte intégralTang, Kai, Ying Xin, Keming Li, Xi Chen et Youhua Tan. « Cell Cytoskeleton and Stiffness Are Mechanical Indicators of Organotropism in Breast Cancer ». Biology 10, no 4 (25 mars 2021) : 259. http://dx.doi.org/10.3390/biology10040259.
Texte intégralEng, Jennifer, Jason Link, Carl Pelz et Rosalie Sears. « Abstract PR010 : Multiplex imaging reveals features of organotropism in pancreatic ductal adenocarcinoma ». Cancer Research 83, no 2_Supplement_2 (15 janvier 2023) : PR010. http://dx.doi.org/10.1158/1538-7445.metastasis22-pr010.
Texte intégralWong, Grace L., Sara Abu Jalboush et Hui-Wen Lo. « Exosomal MicroRNAs and Organotropism in Breast Cancer Metastasis ». Cancers 12, no 7 (7 juillet 2020) : 1827. http://dx.doi.org/10.3390/cancers12071827.
Texte intégralThèses sur le sujet "Organotropisme"
Minet, Antoine. « Bioaccumulation and effects of mercury in cuttlefish in the context of ocean acidification ». Electronic Thesis or Diss., La Rochelle, 2022. http://www.theses.fr/2022LAROS039.
Texte intégralThe common cuttlefish, Sepia officinalis, is a coastal cephalopod known for its eco physiological performance supported by a wide repertoire of behaviors that allows it, despite its short life cycle, to play a central role in food webs. However, it is also known to efficiently accumulate metallic elements such as mercury (Hg), a neurotoxic contaminant in its organic form (methylmercury; MeHg). Moreover, in the context of global changes, ocean acidification (OA) induced by the increase of CO2 emissions, can impact metabolism, development and the central nervous system, especially in young life stages. The present work therefore aims to study the effects of OA on Hg bioaccumulation and the effects of these two neurotoxicants (Hg and CO2) on behavior and cognitive performance in juvenile cuttlefish. In the first place, in-situ measurements showed that Hg accumulated in the brain of cephalopods in methylated form (MeHg). Moreover, experimental approaches using isotopic tracers (stable and radioactive) of Hg have shown that the accumulation of total Hg comes mainly from the assimilation of MeHg present in preys, compared to the accumulation of inorganic mercury (iHg) dissolved in seawater. This MeHg is then very strongly retained despite evidence of Hg demethylation processes in the digestive gland. Surprisingly, OA has no effect on the bioaccumulation efficiencies and metabolism of Hg. In terms of effect, behavioral assays showed that Hg and CO2, alone or in combination, did not impact visual acuity and predation performance in juveniles. However, both induced an increase in locomotor activity, compromised defensive behavior through, in particular, an alteration of disruptive coloration and a non-alignment of lateralization. Among the neural processes likely to be impacted by Hg and CO2, the GABAergic system was analyzed in the optic lobes but showed no obvious link with behavioral responses suggesting more complex effect processes. All of this work therefore questions the effects of future ocean conditions on juvenile’s cuttlefish, and more broadly the impacts on cephalopod populations
Ham, Sunyoung. « The role of breast cancer derived-exosomes in the tumour micro-environment ». Thesis, Queensland University of Technology, 2021. https://eprints.qut.edu.au/208432/1/Sunyoung_Ham_Thesis.pdf.
Texte intégralCarvalho, António. « Tackling Metastasis with Gold Nanoparticles : Inhibition of Intercellular Communication Mediated by Cancer Cells-Derived Exosomes ». Master's thesis, 2022. http://hdl.handle.net/10362/133583.
Texte intégralPelo menos 66.7% das mortes por cancro são atribuídas à presença de metástases, implicando uma doença terminal para a grande maioria dos pacientes diagnosticados com cancro metastático. O passo limitante da cascata de invasão-metastização é o último passo, a colonização. A colonização é o processo pelo qual células tumorais disseminadas penetram tecidos distantes e se adaptam a “solo” desconhecido de modo a prosperar. Para acelerar o processo de colonização, as células cancerígenas libertam frequentemente fatores solúveis e vesículas extracelulares como os exossomas através da circulação sistémica, o que conduz à criação de microambientes permissivos ao desenvolvimento tumoral noutros órgãos, os nichos pré-metastáticos. Descobriu-se que as integrinas exossomais α6β1 e α6β4, libertadas por células do cancro da mama, se ligam especificamente a fibroblastos e células epiteliais residentes nos pulmões. A libertação do conteúdo exossomal nas células recetoras ativa a proteína Src e aumenta a expressão dos genes pro-inflamatórios S100. Esta interação leva à formação de nichos pré-metastáticos no pulmão e promove a metastização com tropismo para o pulmão. Neste caso, a comunicação célula-célula via exossomas entre o tumor primário e microambientes de órgãos distantes é o mediador chave da progressão metastática. Tendo em conta a recente aposta nas terapêuticas de oligonucleótidos antisense e o advento da nanotecnologia, foi produzido um nanoconjugado de ouro com atividade de silenciamento génico. Isto foi alcançado através da funcionalização de nanopartículas de ouro com um oligonucleótido antisense desenhado para silenciar ITGA6, o gene que codifica para a subunidade α6 das integrinas α6β1 e α6β4. A eficácia do silenciamento foi avaliada ao nível do RNA e da proteína usando células MDA-MB-231, e foi verificada também a existência de alterações fenotípicas entre células tratadas e não tratadas. O nanoconjugado demonstrou atividade de silenciamento génico. A redução dos níveis de integrinas α6β1 e α6β4 pode levar à diminuição do empacotamento destes recetores nos exossomas e travar a metastização com tropismo para o pulmão mediada por integrinas. Esta estratégia à nanoescala tem potencial para ser utilizada para prevenir a metastização nos pulmões, mas são necessários mais estudos.
Chapitres de livres sur le sujet "Organotropisme"
Thiery, J. P. « Metastasis : Adhesion, Lectin-Carbohydrate Interaction, Organotropism, Growth Factors ». Dans Cancer Metastasis, 216–18. Berlin, Heidelberg : Springer Berlin Heidelberg, 1989. http://dx.doi.org/10.1007/978-3-642-74236-1_28.
Texte intégralSchirrmacher, V., A. Kowitz, G. Kadmon, R. Benke et P. Altevogt. « Change in metastasis and organotropism of mouse lymphoma variants associated with changes in expression of adhesion molecules and chemotactic responsiveness ». Dans Lectins and Cancer, 171–78. Berlin, Heidelberg : Springer Berlin Heidelberg, 1991. http://dx.doi.org/10.1007/978-3-642-76739-5_12.
Texte intégral« Organotropism ». Dans Encyclopedia of Parasitology, 2014. Berlin, Heidelberg : Springer Berlin Heidelberg, 2016. http://dx.doi.org/10.1007/978-3-662-43978-4_2239.
Texte intégralStock, Christian. « Circulating Tumor Cells : Does Ion Transport Contribute to Intravascular Survival, Adhesion, Extravasation, and Metastatic Organotropism ? » Dans Reviews of Physiology, Biochemistry and Pharmacology. Berlin, Heidelberg : Springer Berlin Heidelberg, 2021. http://dx.doi.org/10.1007/112_2021_68.
Texte intégralActes de conférences sur le sujet "Organotropisme"
Zhong, Yi, Jun Fan, Jinlong Huang et Christine A. Iacobuzio-Donahue. « Abstract 2829 : Identification of transcriptomic signatures of organotropism in pancreatic cancer metastasis ». Dans Proceedings : AACR Annual Meeting 2017 ; April 1-5, 2017 ; Washington, DC. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.am2017-2829.
Texte intégralGe, William H., Giuseppe Tarantino, Emily Robitschek, Michael P. Manos, Lauren Eastman, Olivia Ouyang, Patrick Ott et al. « Abstract 2846 : Stereotypic patterns and genomic correlates of organotropism in metastatic melanoma ». Dans Proceedings : AACR Annual Meeting 2021 ; April 10-15, 2021 and May 17-21, 2021 ; Philadelphia, PA. American Association for Cancer Research, 2021. http://dx.doi.org/10.1158/1538-7445.am2021-2846.
Texte intégralMahal, Katharina, Kelly Brooks, Amit Mandal, Matthew Smith, Nathalie Dhomen et Richard Marais. « Abstract 4844 : CRISPR-generated BAP1 knockdown in uveal melanoma cell lines affects organotropism ». Dans Proceedings : AACR Annual Meeting 2017 ; April 1-5, 2017 ; Washington, DC. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.am2017-4844.
Texte intégralLyden, DC, H. Peinado-Selgas, A. Nitadori, T.-L. Shen, M. Aleckovic, Y. Kang et J. Bromberg. « Abstract BS03-1 : Tumor-derived exosomes promote pre-metastatic niche formation and organotropism ». Dans Abstracts : Thirty-Sixth Annual CTRC-AACR San Antonio Breast Cancer Symposium - Dec 10-14, 2013 ; San Antonio, TX. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/0008-5472.sabcs13-bs03-1.
Texte intégralNguyen, Bastien, Christopher Fong, Renzo DiNatale, Anisha Luthra, Subhiksha Nandakumar, Henry Walch, Walid K. Chatila et al. « Abstract 2834 : Integration of genomic and clinical data from 25,000 patients identifies molecular determinants of metastatic potential and organotropisms ». Dans Proceedings : AACR Annual Meeting 2021 ; April 10-15, 2021 and May 17-21, 2021 ; Philadelphia, PA. American Association for Cancer Research, 2021. http://dx.doi.org/10.1158/1538-7445.am2021-2834.
Texte intégralDidmanidze, Ibraim, et Irma Bagrationi. « INFORMATION PARADIGMS OF ART FROM THE HISTORY OF SOCIAL AESTHETICS ». Dans 9th SWS International Scientific Conferences on ART and HUMANITIES - ISCAH 2022. SGEM WORLD SCIENCE, 2022. http://dx.doi.org/10.35603/sws.iscah.2022/s07.06.
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