Littérature scientifique sur le sujet « Organogel aqueux »
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Articles de revues sur le sujet "Organogel aqueux"
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Giuri, Demetra, Nicola Zanna et Claudia Tomasini. « Low Molecular Weight Gelators Based on Functionalized l-Dopa Promote Organogels Formation ». Gels 5, no 2 (14 mai 2019) : 27. http://dx.doi.org/10.3390/gels5020027.
Texte intégralRésumé :
We prepared the small pseudopeptide Lau-l-Dopa(OBn)2-d-Oxd-OBn (Lau = lauric acid; l-Dopa = l-3,4-dihydroxyphenylalanine; d-Oxd = (4R,5S)-4-methyl-5-carboxyl-oxazolidin-2-one; Bn = benzyl) through a number of coupling reactions between lauric acid, protected l-Dopa and d-Oxd with an excellent overall yield. The ability of the product to form supramolecular organogels has been tested with different organic solvents of increasing polarity and compared with the results obtained with the small pseudopeptide Fmoc-l-Dopa(OBn)2-d-Oxd-OBn. The mechanical and rheological properties of the organogels demonstrated solvent-dependent properties, with a storage modulus of 82 kPa for the ethanol organogel. Finally, to have a preliminary test of the organogels’ ability to adsorb pollutants, we treated a sample of the ethanol organogel with an aqueous solution of Rhodamine B (RhB) for 24 h. The water solution slowly lost its pink color, which became trapped in the organogel.
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Karole, Sarita, Akash Sagar, Anup K. Chakraborty et Kavita R. Loksh. « Formulation, development and characterization of topical organogel of mometasone furoate for the treatment of skin disease ». Indian Journal of Pharmacy and Pharmacology 9, no 1 (15 mars 2022) : 51–56. http://dx.doi.org/10.18231/j.ijpp.2022.009.
Texte intégralRésumé :
Topical glucocorticoid formulations are widely used for effective treatment and control of a variety of dermatoses. Mometasone furoate is a medium potency, synthetic, non-fluorinated topical corticosteroid, indicated for the relief of inflammatory and pruritic manifestations of corticosteroid responsive dermatoses including psoriasis. The percutaneous absorption increases risk associated with systemic absorption of topically applied formulation. Controlled release of the drug to the skin could reduce the side effects while reducing percutaneous absorption. Organogels are semi-solid materials, in which an organic phase is immobilized by a three-dimensional network composed of self-organized system, forming the aqueous phase. The present study deals with the preparation and evaluation of a pluronic lecithin organogel gel containing mometasone furoate for transdermal delivery. Blank pluronic lecithin organogel were prepared using ricinoleic acid as the oil phase. Formulation, Development and Characterization of Topical Organogel of Mometasone Furoate was carried out and evaluated for the treatment of Skin Disease. The absorption maxima of mometasone furoate were determined by running the spectrum of drug solution in double beam ultraviolet spectrophotometer (Labindia UV 3000+) using concentration range of 5-25μg/ml mometasone furoate in 7.4 phosphate buffers. The IR spectrum of sample drug and drug with excipients shows the peak values which are characteristics of the drug. The formulated gel formulation was evaluated with parameter appearance, consistency, drug content pH, viscosity, spreadability, in-vitro release test, washability, extrudability study and stability studies. FT-IR studies revealed no interaction between the drug and excipients. Selected organogels (F3) showed a drug content of 99.45±0.14% and drug release of 99.12 % in10 hrs. The results suggest that the developed organogels formulation containing mometasone furoate can be of actual value for improving the clinical effectiveness in the treatment of psoriasis.
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Razaq, Duaa, Masar Basim Mohsin Mohamed et Lina A. Dahabiyeh. « Formulation and Characterization of Curcumin 12-Hydroxystearic Acid in Triacetin Organogel for Topical Administration ». Al Mustansiriyah Journal of Pharmaceutical Sciences 24, no 2 (8 avril 2024) : 190–204. http://dx.doi.org/10.32947/ajps.v24i2.1011.
Texte intégralRésumé :
Background: Curcumin (CUR) and its derivatives have shown a wide variety of biological activities, such as anti-oxidant, anti-inflammatory, anti-tumor, antimicrobial and antiparasitic effects as well as for the treatment of skin diseases. Due to its physico-chemical limitations such as low aqueous solubility and low bioavailability, we developed curcumin organogel as a topical delivery system to overcome those limitations. The12-hydroxystearic acid (12-HSA) is well known as a low-molecular-weight organogelators (LMOGs) capable of gelling an organic liquid phase. Different concentrations of (12-HSA) in triacetin with 50 mg CUR were gelled and applied for various examinations: tabletop rheology, oil binding capacity, pH measurement, spreadability, in vitro drug release, antibacterial activity and oscillatory rheology studies. The results revealed that the organogels transition temperatures from solid to liquid were greater than the normal body temperature, this helped the organogels keep their shape; they had good spreadability,and the organogels pH levels were within the safe range for the skin . In vitro release data showed that 4% 12HSA+5%CUR +TA (4TA) gave us 100% release after 6 hours. The selected 4TA illustrated good viscoelastic properties in the amplitude sweep test and a frequency-independent as seen in the frequency sweep test. CUR has good antibacterial action against Staphylococcus aureus; Streptococcus pyrogen, Proteus mirabilis, and Escherichia coli, which prevail at the site of wound injury as this pointed out that 4TA organogel can be used for topical wound healing.
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Воронова (Voronova), Марина (Marina) Игоревна (Igorevna), Олег (Oleg) Валентинович (Valentinovich) Суров (Surov), Наталья (Natal'ya) Викторовна (Viktorovna) Рублева (Rubleva), Наталья (Natal'ya) Евгеньевна (Evgenievna) Кочкина (Kochkina) et Анатолий (Anatoliy) Георгиевич (Georgievich) Захаров (Zakharov). « DISPERSIBILITY OF NANOCRYSTALLINE CELLULOSE IN ORGANIC SOLVENTS ». chemistry of plant raw material, no 1 (6 mars 2019) : 39–50. http://dx.doi.org/10.14258/jcprm.2019014240.
Texte intégralRésumé :
Aqueous suspensions of nanocrystalline cellulose (NCC) were obtained by sulfuric acid hydrolysis using the standard procedure. Suspensions, films and airgel of NCC were characterized by various methods: the degree of polymerization was determined, elemental analysis was carried out, the degree of crystallinity and crystallite size were calculated on the basis of X-ray data, the morphology of NCC aerogels was studied using scanning electron microscopy. The particle size of the NCC was determined using a transmission electron microscope, a scanning atomic-force microscope and the method of dynamic light scattering. NFC hydrosols with different pH were used to prepare lyophilized NCC samples. From NCC hydrosols with pH 2.2, by gradual replacement of water with an organic solvent, NCC organogels with acetone, acetonitrile and ethanol were obtained.
The process of dispersion of lyophilized NCC and NCC organogels (acetone, acetonitrile and ethanol) in water and in 11 organic solvents was investigated. The effect of the pH of the initial aqueous suspension of the NCC and the solvent forming the NCC organogel on the repeated dispersibility of the NCC is shown. The optimum pH value of the initial aqueous suspension of NCC was determined, which determines the maximum dispersibility of the lyophilized samples in each specific solvent. It was shown that dispersion of acetone, acetonitrile and ethanol organogels in most of the solvents studied occurs with the formation of particles less than 100 nm.
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Patel, A. R., B. Mankoč, M. D. Bin Sintang, A. Lesaffer et K. Dewettinck. « Fumed silica-based organogels and ‘aqueous-organic’ bigels ». RSC Advances 5, no 13 (2015) : 9703–8. http://dx.doi.org/10.1039/c4ra15437a.
Texte intégralRésumé :
We report the use of fumed silica as a structurant for creating an organogel with a triglyceride solvent (vegetable oil) as the continuous phase. The organogel was further used to prepare aqueous-organic bigels.
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Mehta, Chetna, Ganesh Bhatt et Preeti Kothiyal. « A Review on organogel for skin aging ». Indian Journal of Pharmaceutical and Biological Research 4, no 03 (30 septembre 2016) : 28–37. http://dx.doi.org/10.30750/ijpbr.4.3.5.
Texte intégralRésumé :
Skin aging is one of the prominent problems associated with skin as each part of body ages with the time, skin is the external organ where the sign and symptoms of aging are readily evident. However cosmetics as well as pharmaceutical approaches delayed skin aging. Gel are best fitted in all these essential criteria because of their excellent appearance, smoothness, desired consistency, fast drug release, ease of manufacturing and quality assessment and admirable stability. Recently gel formulation have been modified to yield an advance drug delivery system known as ―organogels‖. Gel define as a semi-solid preparation having an external solvent phase, apolar [organogel] or polar [hydrogel] immobilized within the space available of a three dimensional network structure. Lecithin is a natural surfactant isolated from eggs or soya bean, when it combined with water and non-polar solvent, it form gels. PLO gels have gained importance in recent years as transdermal drug delivery system. It is a thermodynamically stable, visco-elastic system, which is non-irritating, odorless and biodegradable. Pluronic F127 or poloxamer is a copolymer of polyoxyethylene and polyoxypropylene which forms a thermoreversible gel in concentrations between 15-30%w/v. Water plays the role of a structure-forming agent and stabilizes the process of gel formation as it solubilizes the pluronic and other hydrophilic drugs. PLO gel system facilitates the delivery of hydrophilic as well as lipophilic drugs owing to the presence of both oil and aqueous phases within the gel system.
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Ma, Yao, Massimo Cametti, Zoran Džolić et Shimei Jiang. « Selective Cu(ii) sensing by a versatile AIE cyanostilbene-based gel system ». Soft Matter 15, no 30 (2019) : 6145–50. http://dx.doi.org/10.1039/c9sm00955h.
Texte intégralRésumé :
Pyridyl-oxalamido-cyanostilbene 1 is a versatile ambidextrous gelator forming organo-, hydro-, and Cu(ii) specific metallogels. A rare organogel-to-metallogel transformation was also observed upon exposure of 1-DMSO/H2O gel to aqueous Cu(ii).
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Jatav, Mahendra Prasad, et Suman Ramteke. « Formulation and evaluation of lecithin organogel for treatment of arthritis ». International Journal of Scientific World 3, no 2 (1 octobre 2015) : 267. http://dx.doi.org/10.14419/ijsw.v3i2.5028.
Texte intégralRésumé :
<p><strong>Background:</strong> Arthritis is a disease of the joint that involves inflammation of one or more joints. Topical administration of NSAIDs could deliver lornoxicam to the site of action in rheumatic diseases, which would reduce the gastrointestinal complications and side effects of the drug.</p><p><strong>Methods:</strong> In this method, the oily phase was prepared by dispersing the specific amount (ratio; 40:60) of purified lecithin at room temperature in isopropyl myristate as dispersing and emulsifying agent. The aqueous phase of polypropylene was prepared by dispersing a weighed amount of polypropylene and glycerol in water. It was stored at 2-4 oC overnight for the effective dissolution. The aqueous phase was slowly added in oily phase with stirring at 400 rpm using a mechanical stirrer. The prepared organogel of lornoxicam were evaluated for its appearance, organoleptic characteristic, viscosity, gelation temperature, drug content and in vitro release study. In vivo evaluation for analgesic activity of formulation was carried out in terms of skin irritation study, hot plate method; writhing test and edema paw induce method.</p><p><strong>Results:</strong> The drug content of organogel formulations was found in the range of 92.43±2.10-97.93±0.31% indicating uniform distribution of drug through the base and no interaction of drug with component of base. Posthoc Dunnet’s t-test by employing statistical software, GraphPad InStat 3. It’s shown differences between groups were considered significant at P < 0.05.</p><p><strong>Conclusion:</strong> The transdermal organogel formulation of lornoxicam could provide significant anti-inflammatory and antirheumatic activity when applied topically and was observed to be functional for topical delivery of lornoxicam.</p>
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Porpora, Francesca, Luigi Dei, Teresa T. Duncan, Fedora Olivadese, Shae London, Barbara H. Berrie, Richard G. Weiss et Emiliano Carretti. « Non-Aqueous Poly(dimethylsiloxane) Organogel Sponges for Controlled Solvent Release : Synthesis, Characterization, and Application in the Cleaning of Artworks ». Gels 9, no 12 (15 décembre 2023) : 985. http://dx.doi.org/10.3390/gels9120985.
Texte intégralRésumé :
Polydimethylsiloxane (PDMS) organogel sponges were prepared and studied in order to understand the role of pore size in an elastomeric network on the ability to uptake and release organic solvents. PDMS organogel sponges have been produced according to sugar leaching techniques by adding two sugar templates of different forms and grain sizes (a sugar cube template and a powdered sugar template), in order to obtain materials differing in porosity, pore size distribution, and solvent absorption and liquid retention capability. These materials were compared to PDMS organogel slabs that do not contain pores. The sponges were characterized by Fourier-transform infrared spectroscopy with attenuated total reflectance (FTIR-ATR) and compared with PDMS slabs that do not contain pores. Scanning electron microscopy (SEM) provided information about their morphology. X-ray micro-tomography (XMT) allowed us to ascertain how the form of the sugar templating agent influences the porosity of the systems: when templated with sugar cubes, the porosity was 77% and the mean size of the pores was ca. 300 μm; when templated with powdered sugar, the porosity decreased to ca. 10% and the mean pore size was reduced to ca. 75 μm. These materials, porous organic polymers (POPs), can absorb many solvents in different proportions as a function of their polarity. Absorption capacity, as measured by swelling with eight solvents covering a wide range of polarities, was investigated. Rheology data established that solvent absorption did not have an appreciable impact on the gel-like properties of the sponges, suggesting their potential for applications in cultural heritage conservation. Application tests were conducted on the surfaces of two different lab mock-ups that simulate real painted works of art. They demonstrated further that PDMS sponges are a potential innovative support for controlled and selective cleaning of works of art surfaces.
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Bonifazi, Evelyn L., Valeria C. Edelsztein, Guillermo O. Menéndez, Cecilia Samaniego López, Carla C. Spagnuolo et Pablo H. Di Chenna. « Versatile Supramolecular Organogel with Outstanding Stability toward Aqueous Interfaces ». ACS Applied Materials & ; Interfaces 6, no 12 (12 juin 2014) : 8933–36. http://dx.doi.org/10.1021/am5010656.
Texte intégralThèses sur le sujet "Organogel aqueux"
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Rangel, Euzcateguy Geraldine del Valle. « Synthèse, formulation et caractérisation d’organogels aqueux moléculaires/macromoléculaires à base de produits bio-sourcés ». Electronic Thesis or Diss., Université de Lorraine, 2020. http://www.theses.fr/2020LORR0300.
Texte intégralRésumé :
Dans ce travail, un acide aminé naturel, la lysine, a été modifié chimiquement pour synthétiser trois agents gélifiants de structures similaires et différant les uns des autres par un ou deux groupes fonctionnels. Les trois molécules étaient entièrement solubles dans le diméthylsulfoxyde (DMSO) et les mélanges gélifiés DMSO/H2O avec diverses compositions donnant naissance à des organogels aqueux. Des hydrogels pourraient être produits après dialyse de gels DMSO/H2O. La résistance mécanique des gels, la réversibilité thermique/mécanique, la température de transition gel-sol ainsi que la cinétique de formation du gel ont été analysées et corrélées à la structure chimique des gélifiants ainsi qu'à la composition du solvant. Des équations semi-empiriques ont été utilisées pour décrire les résultats expérimentaux. Les résultats de l'observation visuelle, des mesures rhéologiques, des spectres FT-IR et Raman ont été comparés. Nous avons démontré que de subtiles variations dans la structure chimique du gélifiant, modifiaient considérablement certaines propriétés comme le temps de formation du gel (qui variait entre 10s et 1h30) ou la réversibilité thermique. La voie de formulation doit être adaptée au comportement gélifiant de chaque molécule. De plus, une géométrie spécifique a été conçue pour les mesures rhéologiques. La modification des propriétés du gel par l'ajout d'un polysaccharide non ionique (dextrane, Mn 200000 g.mol-1) a également été étudiée en dessous et au-dessus de sa concentration critique de chevauchement. Selon la formulation des gels, leurs propriétés macroscopiques pourraient être adaptées à des applications spécifiquesIn that work, a natural amino acid, lysine, has been chemically modified for synthesizing three gelling agents with similar structures and differing from each other by one or two functional groups. All three molecules were fully soluble in dimethylsulfoxide (DMSO) and gelled DMSO/H2O mixtures with various compositions giving rise to aqueous organogels. Hydrogels could be produced after dialysis of DMSO/H2O gels. Mechanical strength of the gels, thermal/mechanical reversibility, temperature of gel-sol transition as well as kinetics of gel formation were analysed and correlated to the chemical structure of the gelators as well as to the composition of solvent. Semi-empirical equations were used to describe the experimental results. The results of visual observation, rheological measurements, FT-IR and Raman spectra were compared. We demonstrated that subtle variations in the chemical structure of the gelator dramatically modified some properties like the time for gel formation (which varied between 10 s and 1h30) or thermal reversibility. The formulation pathway must be adapted to the gelling behaviour of each molecule. In addition a specific geometry was designed for rheological measurements. The modification of gel properties by the addition of a non ionic polysaccharide (dextran, Mn ≈ 200,000 g.mol-1) was also investigated below and above its critical overlap concentration. According to the formulation of gels, their macroscopic properties could be adapted to specific applications
Chapitres de livres sur le sujet "Organogel aqueux"
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Ozel, B. « Organogels ». Dans Bioactive Delivery Systems for Lipophilic Nutraceuticals, 232–66. The Royal Society of Chemistry, 2023. http://dx.doi.org/10.1039/bk9781839165566-00232.
Texte intégralRésumé :
The majority of nutraceutical compounds have very limited solubility in aqueous solvents. So it is necessary to design systems in order to encapsulate lipophilic nutraceutical compounds. Organogels offer a great potential for the encapsulation of such compounds. Organogels are also able to deliver nutraceuticals to food systems or directly to the human gastrointestinal tract. Moreover, organogel systems protect the encapsulated compounds from oxidation and degradation so that these compounds could maintain their nutritional values. Incorporation of liquid oil containing organogels into food matrices is a practical method to replace the saturated fat content of many food products. Additionally, design of physiologically responsive organogels for the controlled release of nutraceuticals in the human gastrointestinal system is also gaining interest. Another focus in the field is to increase the number of safe and food grade gelators for the production of new and functional organogels. Minimizing the negative effects of organogel production processes is also an important point of interest. This chapter refers to the molecular-physicochemical properties and formation methods of organogels. The applicable range and the positive and negative aspects of various organogel systems have also been presented.
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Mishra, Sunita, et M. A. Firdaus. « Formulation of Edible Bigel with Potential to Trans-Fat Replacement in Food Products ». Dans Food Processing [Working Title]. IntechOpen, 2023. http://dx.doi.org/10.5772/intechopen.110517.
Texte intégralRésumé :
A new issue for the scientific community is to find efficient replacements for unhealthy fat without damaging the organoleptic qualities of the food product in light of growing concerns about the consumption of harmful trans fats in the diet. Bigel is supposedly a novel structured fat system utilised for industrial purposes due to their nutritional advantages, one of numerous solutions intended to replace trans fats in food. These have a lot of potential in the food industry, and are composed of an aqueous phase known as a hydrogel and an organic phase known as an organogel or oleogel. A gel known as an oleogel has oil as its liquid component. Oleogelators, which aid in the development of gels, frequently have low molecular weight, whereas typical hydrogelators have large molecular weight since they are polymeric. A hydrogel is a gel in which water serves as the immobilised phase. Therefore, a bigel is a biphasic system made up of an oleogel and a hydrogel. This chapter will concentrate on the various bigel formulation techniques and chemistry, as well as their latest food uses, and other industries that fit their requirements.