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Littérature scientifique sur le sujet « OdV »

Auteur : Grafiati

Publié le 9 mars 2023

Mis à jour le 10 mars 2023

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Articles de revues sur le sujet "OdV"

Haas-Stapleton, Eric J., Jan O. Washburn et Loy E. Volkman. « P74 Mediates Specific Binding of Autographa californica M Nucleopolyhedrovirus Occlusion-Derived Virus to Primary Cellular Targets in the Midgut Epithelia of Heliothis virescens Larvae ». Journal of Virology 78, n^o 13 (1 juillet 2004) : 6786–91. http://dx.doi.org/10.1128/jvi.78.13.6786-6791.2004.

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ABSTRACT P74, an envelope protein of the occlusion-derived virus (ODV) of Autographa californica M nucleopolyhedrovirus (AcMNPV), is critical for oral infection of Trichoplusia ni larvae. The role of P74 during primary infection, however, is unknown. Here we provide evidence that P74 facilitates binding of AcMNPV ODV to a specific receptor within the larval midgut epithelia of another host species, Heliothis virescens. We adapted a fluorescence dequenching assay to compare binding, fusion, and competition of wild-type AcMNPV ODV in vivo with itself and with the ODV of a p74-deficient AcMNPV mutant. We found that relative to wild-type ODV, binding and fusion of ODV deficient in P74 were both qualitatively and quantitatively different. Unlike wild-type ODV, an excess of P74-deficient ODV failed to compete effectively with wild-type ODV binding, and the overall binding level of the mutant ODV was one-third that of the wild type. These results implicated P74 as an ODV attachment protein that binds to a specific receptor on primary target cells within the midgut.

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Deng, Fei, Ranran Wang, Minggang Fang, Yue Jiang, Xushi Xu, Hanzhong Wang, Xinwen Chen et al. « Proteomics Analysis of Helicoverpa armigera Single Nucleocapsid Nucleopolyhedrovirus Identified Two New Occlusion-Derived Virus-Associated Proteins, HA44 and HA100 ». Journal of Virology 81, n^o 17 (20 juin 2007) : 9377–85. http://dx.doi.org/10.1128/jvi.00632-07.

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ABSTRACT Sodium dodecyl sulfate-polyacrylamide gel electrophoresis and mass spectrometry were used to analyze the structural proteins of the occlusion-derived virus (ODV) of Helicoverpa armigera single nucleocapsid nucleopolyhedrovirus (HearNPV), a group II NPV. Twenty-three structural proteins of HearNPV ODV were identified, 21 of which have been reported previously as structural proteins or ODV-associated proteins in other baculoviruses. These include polyhedrin, P78/83, P49, ODV-E18, ODV-EC27, ODV-E56, P74, LEF-3, HA66 (AC66), DNA polymerase, GP41, VP39, P33, ODV-E25, helicase, P6.9, ODV/BV-C42, VP80, ODV-EC43, ODV-E66, and PIF-1. Two proteins encoded by HearNPV ORF44 (ha44) and ORF100 (ha100) were discovered as ODV-associated proteins for the first time. ha44 encodes a protein of 378 aa with a predicted mass of 42.8 kDa. ha100 encodes a protein of 510 aa with a predicted mass of 58.1 kDa and is a homologue of the gene for poly(ADP-ribose) glycohydrolase (parg). Western blot analysis and immunoelectron microscopy confirmed that HA44 is associated with the nucleocapsid and HA100 is associated with both the nucleocapsid and the envelope of HearNPV ODV. HA44 is conserved in group II NPVs and granuloviruses but does not exist in group I NPVs, while HA100 is conserved only in group II NPVs.

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Washburn, Jan O., Eric H. Lyons, Eric J. Haas-Stapleton et Loy E. Volkman. « Multiple Nucleocapsid Packaging of Autographa californica Nucleopolyhedrovirus Accelerates the Onset of Systemic Infection in Trichoplusia ni ». Journal of Virology 73, n^o 1 (1 janvier 1999) : 411–16. http://dx.doi.org/10.1128/jvi.73.1.411-416.1999.

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ABSTRACT Among the nucleopolyhedroviruses (Baculoviridae), the occlusion-derived virus (ODV), which initiates infection in host insects, may contain only a single nucleocapsid per virion (the SNPVs) or one to many nucleocapsids per virion (the MNPVs), but the significance of this difference is unclear. To gain insight into the biological relevance of these different packaging strategies, we compared pathogenesis induced by ODV fractions enriched for multiple nucleocapsids (ODV-M) or single nucleocapsids (ODV-S) ofAutographa californica multicapsid nucleopolyhedrovirus (AcMNPV) containing a β-galactosidase reporter gene. In time course experiments wherein newly molted fourth-instarTrichoplusia ni were challenged with doses of ODV-S or ODV-M that yielded the same final mortality (∼70%), we characterized viral foci as either being restricted to the midgut or involving tracheal cells (the secondary target tissue, indicative of systemic infection). We found that while the timing of primary infection by ODV-S and ODV-M was similar, ODV-S established significantly more primary midgut cell foci than ODV-M, but ODV-M infected tracheal cells at twice the rate of ODV-S. The more efficient establishment of tracheal infections by ODV-M decreased the probability that infections were lost by midgut cell sloughing, explaining why higher numbers of primary infections established by ODV-S within larvae were needed to achieve the same final mortality. These results showed that the multiple nucleocapsid packaging strategy of AcMNPV accelerates the onset of irreversible systemic infections and may indicate why MNPVs have wider individual host ranges than SNPVs.

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Braunagel, Sharon C., Jared K. Burks, German Rosas-Acosta, Robert L. Harrison, H. Ma et M. D. Summers. « Mutations within the Autographa californicaNucleopolyhedrovirus FP25K Gene Decrease the Accumulation of ODV-E66 and Alter Its Intranuclear Transport ». Journal of Virology 73, n^o 10 (1 octobre 1999) : 8559–70. http://dx.doi.org/10.1128/jvi.73.10.8559-8570.1999.

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ABSTRACT Previous reports indicate that mutations within theAutographa californica nucleopolyhedrosis virusFP25K gene (open reading frame 61) significantly reduce incorporation of enveloped nucleocapsids into viral occlusions. We report that FP25K is a nucleocapsid protein of both the budded virus (BV) and occluded virus (ODV), and we describe the effects of twoFP25K mutations (480-1 [N-terminal truncation] and FP-βgal [C-terminal fusion]) on the expression and cellular localization of ODV-E66 and ODV-E25. Significantly decreased amounts of ODV-E66 are detected in cells infected with 480-1 or FP-βgal viral mutants, even though during FP-βgal infection, steady-state levels of ODV-E66 transcripts remain unchanged. While ODV-E66 is normally detected in intranuclear microvesicles and ODV envelopes by 24 h postinfection (p.i.), ODV-E66 remains cytosolic throughout infection in cells infected with 480-1 virus (up to 96 h p.i.), and its intranuclear localization is not detected until 96 h p.i. in cells infected with the FP-βgal mutant virus. The nuclear localization of ODV-E25 is not affected during infection by the FP-βgal mutant; however, its trafficking is significantly delayed during infection by the 480-1 mutant. Temporal Western blot analyses of cell lysates show that both 480-1 and FP-βgal mutant virus infections result in altered accumulation patterns of several structural proteins, including gp67, BV/ODV-E26, and the major capsid protein p39. In addition to BV/ODV-E26, ODV-E66 and gp67 may interact with FP25K, and ODV-E25 and p39 may also be components of a protein complex containing ODV-E66 and FP25K. Together, these data suggest that FP25K and its associated protein complex(es) may play an important role in the targeting and intracellular transport of viral proteins during infection.

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Ohkawa, Taro, Jan O. Washburn, Ronika Sitapara, Eric Sid et Loy E. Volkman. « Specific Binding of Autographa californica M Nucleopolyhedrovirus Occlusion-Derived Virus to Midgut Cells of Heliothis virescens Larvae Is Mediated by Products of pif Genes Ac119 and Ac022 but Not by Ac115 ». Journal of Virology 79, n^o 24 (15 décembre 2005) : 15258–64. http://dx.doi.org/10.1128/jvi.79.24.15258-15264.2005.

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ABSTRACT Per os infectivity factors PIF1 (Ac119) and PIF2 (Ac022), like P74, are essential for oral infection of lepidopteran larval hosts of Autographa californica M nucleopolyhedrovirus (AcMNPV). Here we show that Ac115 also is a PIF (PIF3) and that, unlike PIF1 and PIF2, it does not mediate specific binding of AcMNPV occlusion-derived virus (ODV) to midgut target cells. We used an improved in vivo fluorescence dequenching assay to compare binding, fusion, and competition among control AcMNPV ODV and the ODVs of AcMNPV PIF1, PIF2, and PIF3 deletion mutants. Our results showed that binding and fusion of PIF1 and PIF2 mutants, but not the PIF3 mutant, were both qualitatively and quantitatively different from those of control ODV. Unlike control and PIF3-deficient ODV, an excess of PIF1- or PIF2-deficient ODV failed to compete effectively with control ODV's binding to specific receptors on midgut epithelial cells. Moreover, the levels of PIF1- and PIF2-deficient ODV binding were depressed threefold compared to control levels. Binding, fusion, and competition by PIF3-deficient ODV, however, were all indistinguishable from those of control ODV. These results implicated PIF1 and PIF2 as ODV envelope attachment proteins that mediate specific binding to primary target cells within the midgut. In contrast, PIF3 mediates another unidentified, but critical, early event during primary infection.

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Haas-Stapleton, Eric J., Jan O. Washburn et Loy E. Volkman. « Spodoptera frugiperda resistance to oral infection by Autographa californica multiple nucleopolyhedrovirus linked to aberrant occlusion-derived virus binding in the midgut ». Journal of General Virology 86, n^o 5 (1 mai 2005) : 1349–55. http://dx.doi.org/10.1099/vir.0.80845-0.

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Spodoptera frugiperda larvae are highly resistant to oral infection by Autographa californica multiple nucleopolyhedrovirus (AcMNPV) (LD50, ∼9200 occlusions), but extremely susceptible to budded virus within the haemocoel (LD50, <1 p.f.u.). The inability of AcMNPV occlusion-derived virus (ODV) to establish primary infections readily within midgut cells accounts for a major proportion of oral resistance. To determine whether inappropriate binding of AcMNPV ODV to S. frugiperda midgut cells contributes to lack of oral infectivity, the binding and fusion properties of AcMNPV ODV were compared with those of the ODV of a new isolate of Spodoptera frugiperda multiple nucleopolyhedrovirus (SfMNPV) obtained from a field-collected larva (oral LD50, 12 occlusions). By using a fluorescence-dequenching assay conducted in vivo, it was found that AcMNPV ODV bound to the midgut epithelia of S. frugiperda larvae at ∼15 % of the level of SfMNPV ODV, but that, once bound, the efficiencies of fusion for the two ODVs were similar: 60 % for AcMNPV and 53 % for SfMNPV. Whilst the difference in binding efficiencies was significant, it could not account entirely for the observed differences in infectivity. Competition experiments, however, revealed that, in S. frugiperda larvae, SfMNPV ODV bound to a midgut cell receptor that was not bound by AcMNPV ODV, indicating that ODV interaction with a specific receptor(s) was necessary for productive infection of midgut columnar epithelial cells. Fusion in the absence of this ligand–receptor interaction did not result in productive infections.

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Braunagel, S. C., H. He, P. Ramamurthy et M. D. Summers. « Transcription, Translation, and Cellular Localization of ThreeAutographa californicaNuclear Polyhedrosis Virus Structural Proteins : ODV-E18, ODV-E35, and ODV-EC27 ». Virology 222, n^o 1 (août 1996) : 100–114. http://dx.doi.org/10.1006/viro.1996.0401.

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Mu, Jingfang, Jan W. M. van Lent, Guy Smagghe, Yun Wang, Xinwen Chen, Just M. Vlak et Monique M. van Oers. « Live imaging of baculovirus infection of midgut epithelium cells : a functional assay of per os infectivity factors ». Journal of General Virology 95, n^o 11 (1 novembre 2014) : 2531–39. http://dx.doi.org/10.1099/vir.0.068262-0.

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The occlusion-derived viruses (ODVs) of baculoviruses are responsible for oral infection of insect hosts, whereas budded viruses (BVs) are responsible for systemic infection within the host. The ODV membrane proteins play crucial roles in mediating virus entry into midgut epithelium cells to initiate infection and are important factors in host-range determination. For Autographa californica multiple nucleopolyhedrovirus (AcMNPV), seven conserved ODV membrane proteins have been shown to be essential for oral infectivity and are called per os infectivity factors (PIFs). Information on the function of the individual PIF proteins in virus entry is limited, partly due to the lack of a good in vitro system for monitoring ODV entry. Here, we constructed a baculovirus with EGFP fused to the nucleocapsid to monitor virus entry into primary midgut epithelium cells ex vivo using confocal fluorescence microscopy. The EGFP-labelled virus showed similar BV virulence and ODV infectivity as WT virus. The ability to bind and enter host cells was then visualized for WT AcMNPV and viruses with mutations in P74 (PIF0), PIF1 or PIF2, showing that P74 is required for ODV binding, whilst PIF1 and PIF2 play important roles in the entry of ODV after binding to midgut cells. This is the first live imaging of ODV entry into midgut cells and complements the genetic and biochemical evidence for the role of PIFs in the oral infection process.

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Sparks, Wendy O., Amy Rohlfing et Bryony C. Bonning. « A peptide with similarity to baculovirus ODV-E66 binds the gut epithelium of Heliothis virescens and impedes infection with Autographa californica multiple nucleopolyhedrovirus ». Journal of General Virology 92, n^o 5 (1 mai 2011) : 1051–60. http://dx.doi.org/10.1099/vir.0.028118-0.

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Baculoviruses infect their lepidopteran hosts via the midgut epithelium through binding of occlusion-derived virus (ODV) and fusion between the virus envelope and microvillar membranes. To identify genes and sequences that are involved in this process, a random phage display library was screened for peptides that bound to brush border membrane vesicles (BBMV) derived from the midgut epithelium of Heliothis virescens. Seventeen peptides that bound to BBMV were recovered. Two of these, HV1 and HV2, had sequence similarity to the ODV envelope protein ODV-E66 that is found in five species of alphabaculoviruses. Chemically synthesized versions of HV1 and HV2, and two peptides (AcE66A and AcE66B) derived from similar sequences of Autographa californica multiple nucleopolyhedrovirus (AcMNPV) ODV-E66, bound to unfixed cryosections of whole midgut tissues. AcE66A, but not HV1, bound to H. virescens gut BBMV proteins on a far-Western blot. Competition assays with HV1 and purified AcMNPV ODV resulted in decreased mortality of H. virescens larvae at a dose of 1 LD50, and a significant increase in survival time at higher virus concentrations. These results suggest a role for ODV-E66 in baculovirus infection of lepidopteran larval midgut epithelium.

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Parrish, David D., et Christine A. Ennis. « Estimating background contributions and US anthropogenic enhancements to maximum ozone concentrations in the northern US ». Atmospheric Chemistry and Physics 19, n^o 19 (9 octobre 2019) : 12587–605. http://dx.doi.org/10.5194/acp-19-12587-2019.

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Abstract. US ambient ozone concentrations have two components: US background ozone and enhancements produced from the country's anthropogenic precursor emissions. Only the enhancements effectively respond to national emission controls. We investigate the temporal evolution and spatial variability in the largest ozone concentrations, i.e., those that define the ozone design value (ODV) upon which the National Ambient Air Quality Standard (NAAQS) is based, within the northern tier of US states. We focus on two regions: rural western states, with only small anthropogenic precursor emissions, and the urbanized northeastern states, which include the New York City urban area, the nation's most populated. The US background ODV (i.e., the ODV remaining if US anthropogenic precursor emissions were reduced to zero) is estimated to vary from 54 to 63 ppb in the rural western states and to be smaller and nearly constant (45.8±3.0 ppb) throughout the northeastern states. These US background ODVs correspond to 65 % to 90 % of the 2015 NAAQS of 70 ppb. Over the past 2 to 3 decades US emission control efforts have decreased the US anthropogenic ODV enhancements at an approximately exponential rate, with an e-folding time constant of ∼22 years. These ODV enhancements are relatively large in the northeastern US, with state maximum ODV enhancements of ∼35–64 ppb in 2000, but are not discernible in the rural western states. The US background ODV contribution is significantly larger than the present-day ODV enhancements due to photochemical production from US anthropogenic precursor emissions in the urban as well as the rural regions investigated. Forward projections of past trends suggest that average maximum ODVs in northeastern US will drop below the NAAQS of 70 ppb by about 2021, assuming that the exponential decrease in the ODV enhancements can be maintained and the US background ODV remains constant. This estimate is much more optimistic than in the Los Angeles urban area, where a similar approach estimates the maximum ODV to reach 70 ppb in ∼2050 (Parrish et al., 2017a). The primary reason for this large difference is the significantly higher US ODV background (62.0±2.0 ppb) estimated for the Los Angeles urban area. The approach used in this work has some unquantified uncertainties that are discussed. Models can also estimate US background ODVs; some of those results are shown to correlate with the observationally based estimates derived here (r2 values for different models are ∼0.31 to 0.90), but they are on average systematically lower by 4 to 13 ppb. Further model improvement is required until their output can accurately reproduce the time series and spatial variability in observed ODVs. Ideally, the uncertainties in the model and observationally based approaches can then be reduced through additional comparisons.

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Thèses sur le sujet "OdV"

Chambers, Adam C. « The role of ODV structural proteins in baculovirus replication ». Thesis, Oxford Brookes University, 2012. https://radar.brookes.ac.uk/radar/items/b1027647-229d-acb7-0839-8aee864cc8f3/1/.

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Baculoviruses are arthropod-specific viruses with a circular, double-stranded DNA genome (80-180 kb). Two structural forms are produced during virus replication, comprising budded virus (BV) and occlusion-derived virus (ODV). The BV is produced from 12 hours post infection (hpi) and spreads the infection from tissue to tissue within the host. The ODV is formed 20 hpi and enveloped within occlusion bodies (OBs). The aim of this project was to elucidate the mechanisms involved in ODV production by deleting putative genes involved in ODV, but not BV production. A secondary aim of the project was to determine whether removing these genes improved the quantity/quality of recombinant proteins produced by baculovirus expression vectors.

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Burks, Jared K. « Identification of the membrane association of BV/ODV E26 and the domains in BV/ODV E26 responsible for nuclear trafficking to intranuclear microvesicles ». Texas A&M University, 2005. http://hdl.handle.net/1969.1/4924.

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The baculovirus Autographa californica nucleopolyhedrovirus (AcNPV) has two viral forms, budded virus (BV) and occlusion derived virus (ODV). The envelopment of these two viral forms occurs at different locations: BV acquires envelopes at the plasma membrane while ODV acquires envelopes in the nucleus. The two viral forms carry out different functions in the viral life cycle. The purpose of this study is to investigate how viral envelope proteins sort/traffic to the nucleus. Of particular interest is BV/ODV E26 (E26). E26 is an envelope protein of both BV and ODV (Braunagel and Summers, 1994); therefore it must traffic to the plasma membrane and the nucleus during infection. Thus, E26 is a bi-directional trafficking protein, which interacts with membranes in both locations of the cell. As such it has been shown that there are several immunoreactive forms of E26 (Beniya, Braunagel, and Summers, 1998). The da26 gene produces at least 2 protein products of 26 and 28 kDa with different functions respectively, which correlate with localization, solubility, membrane association, and temporal requirements. The 28 kDa form is likely a soluble protein that interacts with transcriptional activators and DNA in the nucleus in the early stages of infection. A part of the 26 kDa population is a membrane bound form interacting with an integral membrane protein in the ER and likely functions as an INM sorting factor. The 26 kDa membrane bond form is also found in the inner nuclear membrane, intra-nuclear microvesicles, ODV envelopes, and ODV in the nucleus.

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Sparks, Wendy Olissa. « Interaction of the baculovirus occlusion-derived virus envelope proteins ODV-E56 and ODV-E66 with the midgut brush border microvilli of the tobacco budworm, Heliothis virescens (Fabricius) ». [Ames, Iowa : Iowa State University], 2010. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3403836.

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Williamson, Shawn T. « Trafficking of integral membrane proteins of the inner nuclear membrane can be mediated by the ''sorting motif'' of autographa californica nucleopolyhedrovirus odv-e66 ». Texas A&M University, 2005. http://hdl.handle.net/1969.1/4353.

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The amino-terminal 33 amino acids of the baculovirus integral membrane protein, ODV-E66, are sufficient for localization of fusion proteins to viralinduced intranuclear microvesicles (MV) and occlusion derived virus envelopes during infection, and has been termed the sorting motif (SM). When abundantly expressed, SM-fusions are also detected in the inner nuclear membrane (INM), outer nuclear membrane and endoplasmic reticulum of infected cells, suggesting proteins with the SM use the same trafficking pathway as cellular INM proteins to traffic to nuclear membranes. This study identifies the essential characteristics required for sorting of the SM to the INM of uninfected cells, and the MV and ODV envelopes of infected cells. These features are an 18 amino acid transmembrane sequence that lacks polar and charged amino acids (a.a.) with a cluster of charged a.a. spaced 5-11 residues from the end of the transmembrane sequence. A comparison of the a.a. sequence of these SM features with cellular INM proteins shows the features are conserved. The model of INM protein sorting and localization predicts the only known sorting event during INM protein trafficking is immobilization/retention in the INM. This study uses confocal microscopy and fluorescence recovery after photobleaching to compare the localization and mobility of lamin B receptor (LBR) fusions (which contain SM-like sequences) to a viral SM fusion when expressed in either mammalian or insect cells. The results show that immobilization is not necessarily required for accumulation of proteins in the INM. Furthermore, the results from infected cells show that an active sorting event, likely independent of immobilization, can distinguish the viral SM from cellular sequences similar to the SM. The results of this study show that sorting of proteins to the INM can be mediated by the viral SM or INM protein SM-like sequences that can function either independent of, or in addition to, immobilization. These data combined with recent reports suggest that in addition to diffusion:retention a signal mediated mechanism for sorting and localization to the INM can occur.

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FEDERICI, FRANCESCA MARIA. « L'Organismo di Vigilanza ai sensi del d.lgs. 231/2001 : compiti e responsabilità ». Doctoral thesis, Università degli Studi di Milano-Bicocca, 2020. http://hdl.handle.net/10281/262962.

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Oggigiorno, a quasi vent’anni di vigenza del Decreto, nella prassi l’adozione del Modello organizzativo (“MOG” o “Modello”) si è assai diffusa tra le aziende, soprattutto medio-grandi e, specularmente, si è assistito a un florilegio di contestazioni e di condanne, ai sensi del d.lgs. 231/2001. In tale contesto, l’Organismo di Vigilanza (di seguito anche “OdV”) ha da sempre rivestito, secondo l’impianto stesso della normativa, un’imprescindibile funzione. E’ quindi diventato sempre più frequente che professionisti di varia estrazione (per lo più avvocati e commercialisti, ma non solo) affianchino alla propria attività ‘tradizionale’ quella connessa all’incarico quale membro di uno (o più) Organismi di Vigilanza. Secondo l’opinione di chi scrive, a tale ramificazione della pratica professionale, non sempre si accompagna una piena consapevolezza dei compiti connaturati al ruolo di componente di OdV e delle conseguenze derivanti dallo svolgimento di un’attività non sempre approfondita; ciò sarebbe invece auspicabile, non solo nell’interesse dell’ente che abbia scelto di dotarsi di un Modello – e che pertanto nutre una legittima aspettativa circa l’adempimento di tali compiti secondo le best practices –, ma anche nell’interesse della stessa persona fisica che, rivestendo un ruolo tanto delicato quale quello di componente dell’Organismo di Vigilanza, potrebbe trovarsi indagata e/o imputata in un procedimento penale, oltre che citata in giudizio innanzi al tribunale civile per una richiesta di risarcimento danni avanzata dall’ente. La presente Tesi, dunque, ha avuto l’obbiettivo di percorrere gli aspetti più rilevanti legati all’operatività dell’Organismo di Vigilanza. Si è partiti dall’analisi della sua natura e della sua composizione, per poi passare al nucleo inaggirabile dei compiti da assolvere in tutte le fasi dell’incarico – insediamento, pianificazione delle attività, svolgimento in concreto della vigilanza, cessazione – fino ad arrivare all’esame dell’influenza che il corretto o scorretto svolgimento di tali compiti può riverberare sulla prova giudiziale circa l’efficace attuazione di un Modello idoneo a prevenire reati, così come richiesto ai fini del riconoscimento della scriminante di cui all’art. 6 del d.lgs. 231/2001. La trattazione di tali temi rappresenta il substrato fondamentale sulla base del quale si è sviluppato l’argomento centrale – e più problematico – relativo alla possibilità di imputare una qualche forma di responsabilità (penale e/o civile) ai componenti dell’Organismo di Vigilanza, valutando anche il generale trend in materia, espresso oltre che dalla dottrina anche dalle scarsissime pronunce giurisprudenziali in materia
Nowadays, the adoption of the organizational model ("MOG") is very widespread among companies, especially medium-large ones and, in particular, there has been several convictions, pursuant to the Legislative Decree 231/2001. In this context, the Supervisory Body (hereinafter also the "SB") has always played an essential role. It has therefore become increasingly common for professionals from various backgrounds (mostly lawyers and accountants, but not only) to combine their traditional activity with the one connected to the position as a member of one (or more) Supervisory Bodies. According to our opinion, the ramifications of professional practice is not always accompanied by a full observation of the tasks connected to the role of component of the SB and of the consequences deriving from carrying out a not always correct activity; this would instead be desirable, not only in the interest of the company that he had chosen to adopt a Model, but also in the interest of the same individual who, playing a role as delicate as that of member of a Supervisory Body, could be investigated and/or accused in a criminal proceeding, as well as sued before the civil court for a request for compensation for damages. Therefore, this Thesis has had the objective of covering the most relevant aspects related to the Supervisory Body. We started from the analysis of its nature and its composition, to then move on to the core of the tasks to be carried out in all the phases of the assignment - settlement, planning of activities, performance of supervision in practice, termination - up to the exam of the influence that a correct or incorrect performance of these tasks can reflect on the judicial proof of the suitability of the Model in order to prevent crimes, as required for the application of the exoneration clause provide by Rule 6 of Legislative Decree 231/2001. The discussion of these issues concern the fundamental substratum on the basis of which the central - and most problematic - argument related to the possibility of attributing a form of responsibility (criminal and / or civil) to the members of the Supervisory Body, was developed, also evaluating the general trend in the matter, expressed not only by doctrine but also by very few judicial decisions on this subject.

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Mirko, Bogdanović. « Uzvišenost ideje – komparativna analiza engleske klasicističke i romantičarske ode ». Phd thesis, Univerzitet u Novom Sadu, Filozofski fakultet u Novom Sadu, 2015. http://www.cris.uns.ac.rs/record.jsf?recordId=90692&source=NDLTD&language=en.

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Oda kao umjetnička forma, lijepo i uzvišeno, razum i mašta, dinamički imatematički uzvišeno, uzvišenost forme i uzvišenost ideje, subjektivizacija uzvišenosti, nekisu od ključnih pojmova kojima se bavi ovo istraživanje. Međutim, u širem kontekstu, onoobuhvata i pojmove individualnog i opšteg, vječnog i prolaznog, konačnog i beskonačnog,ljudskog i mitskog, ljudskog i božanskog, čovjeka i prirode. Sva ta pitanja, naime, prožimajuse u uzvišenim okvirima ode, koja je svojim postojanjem obilježavala najsvjetlije tačkepojedinih epoha i upisivala ih u veličanstvenu hroniku ljudske istorije. Ovaj rad predstavljaosvrt na tu zlatnu hroniku u kojoj će, nadamo se, i naša epoha upisati nekoliko stihova.
Ode as an artistic form, beautiful and sublime, reason and imagination,dynamically and mathematically sublime, the sublimity of a form and the sublimity of anidea, subjectivity of the sublime, are some of the key terms of this study. However, insomewhat wider context, it also includes the individual and the universal, eternal andtemporal, finite and infinite, human and mythical, human and divine, man and nauture. Allthese questions are intertwined in the sublime frame of an ode, which, by its own existence,has marked the brightest spots of each epoch and written them in the magnificent chronicle ofhuman history. This work represents the retrospect of that golden chronicle in which our ownepoch will hopefully write a few lines.

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Medeiros, Gabriel Londe. « Dos ODM aos ODS : o papel das cidades na agenda 2030 ». Master's thesis, Instituto Superior de Economia e Gestão, 2019. http://hdl.handle.net/10400.5/19706.

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Mestrado em Desenvolvimento e Cooperação Internacional
Os modelos de desenvolvimento adotados desde os anos 1950s promoveram deslocamentos do campo em direção as cidades. Durante décadas esses deslocamentos de pessoas foram ignorados por estes modelos que não previram os impactos nas cidades. Esses deslocamentos acabaram por provocar o acirramento dos problemas e desafios nas cidades. A Cooperação Descentralizada, instrumento pela qual os atores subnacionais cooperavam entre si, tem possibilitado a troca de experiências e práticas, para lidar com esses problemas e desafios. No início do século XXI é lançada a Agenda do Milênio (2000-2015). No entanto, apesar das expectativas, as cidades acabaram por não ser inseridas nesta agenda. A partir da nova Agenda 2030 para o Desenvolvimento Sustentável lançada em 2016, e para ser implementada até 2030, é que as cidades emergem como atrizes centrais. Este trabalho final de mestrado (TFM) analisa de forma crítica as razões que explicam a centralidade das cidades nesta nova agenda global dos ODS em um contexto de crescente interdependência entre os atores e ampliação da Cooperação Descentralizada.
The development models adopted since the 1950s have promoted displacements from the countryside to the cities. For decades, these displacements of people were ignored by those models that did not predict impacts on cities. The consequences of these displacements were the intensification of problems and challenges in cities. Decentralized Cooperation, an instrument through which subnational actors cooperate with each other, has enabled the exchange of experiences and practices to deal with these problems and challenges. At the beginning of the 21st century the Millennium Declaration (2000-2015) is launched. However, despite expectations, cities were not included in this agenda. From the new 2030 Agenda for Sustainable Development launched in 2016, and to be implemented by 2030, cities emerge as central actresses. This final Master's work critically analyzes the reasons that explain the centrality of cities in this new global agenda of SDGs in a context of increasing interdependence between actors and expansion of Decentralized Cooperation.
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Velloso, Rebeca Santos Wanderley. « O Brasil e o combate à pobreza : dos ODM aos ODS ». Master's thesis, Instituto Superior de Economia e Gestão, 2019. http://hdl.handle.net/10400.5/19352.

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Mestrado em Desenvolvimento e Cooperação Internacional
Essa dissertação tem como objetivo analisar o fenómeno da pobreza desde uma perspetiva multidimensional, holística de políticas públicas de proteção social. Sendo a pobreza um dos grandes desafios do mundo atual, presente como metas de erradicação e superação em ambas agendas de desenvolvimento da ONU, se propõe a analisar o fenómeno da pobreza no Brasil para entender como a agenda global da ONU influencia na formulação de políticas públicas sociais domésticas.
This dissertation aims to analyze the phenomenon of poverty from a multidimensional, holistic perspective of public policies of social protection. Since poverty is one of the great challenges of the present world and it is set as a goal of reduction and eradication in both UN development agendas, this work proposes to analyze the phenomenon of poverty in Brazil to understand how the UN global agenda influences the formulation of domestic social public policies.
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Teixeira, Francisco Diniz [UNESP]. « Na senda tradutória da ode : Horácio e Filinto Elísio ». Universidade Estadual Paulista (UNESP), 2018. http://hdl.handle.net/11449/154385.

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O trabalho que ora se encerra, tencionou ao longo do curso de doutoramento efetuar uma investigação acerca da ode enquanto gênero literário, na sua matriz latina a partir do estudo da poesia horaciana e das projeções desta na poesia de Francisco Manoel do Nascimento, poeta neoclássico conhecido pelo pseudônimo de Filinto Elísio. Para tornar isso possível, foi necessário fazer o levantamento da fortuna crítica, a partir de estudos que permitissem a compreensão da ode enquanto gênero ligado ao arquigênero, vislumbrado sob o conceito “Lírico”. Entendendo-se que a transposição de uma forma antiga para as literaturas vernáculas só se torna possível através da tradução, optou-se por delimitar o corpus de trabalho para as onze odes de Horácio que Filinto Elísio traduziu e que, juntamente com as odes de sua autoria, compõem o maior corpus de odes produzidas no Século das Luzes. O estudo de tradução levado a cabo se ancorou no referencial teórico encontrado nos escritos de Henri Meschonnic, Haroldo de Campos e Antony Pym. Evidentemente, o estudo proposto não se limitou aos referenciais teóricos necessários para o desvelamento da prática tradutória do poeta luso, sem que antes se resgatasse o peso de suas ideias estéticas, do contexto histórico-artístico em que ele se inseriu e da recepção de suas ideias e obras na história da literatura portuguesa. Ao fim do trabalho, concluiu-se que a criação artística prolífica entre os poetas neoclássicos, particularmente na obra de Filinto Elísio, se deve ao estudo e tradução – etapa fundamental – das Odes horacianas, tomadas como matriz do gênero e sinônimo de bom gosto no contexto intelectual do século XVIII.
El trabajo que se concluye acá, pretendió, a lo largo del curso de doctorado, efectuar una investigación acerca de la oda como género literario, en su matriz latina a partir del estudio de la poesía horaciana y sus proyecciones en la poesía de Francisco Manoel do Nascimento, poeta neoclásico portugués conocido por el pseudónimo de Filinto Elísio. Para hacerla posible, fue necesario investigar el acervo crítico acerca del tema, a partir de estudios que permitiesen la comprensión de la oda como género vinculado al archigénero, vislumbrado bajo el concepto "Lírico". Comprendiendo que la transposición de una forma antigua a las literaturas vernáculas sólo se hace posible a través de la traducción, se optó por delimitar el corpus de trabajo para las once odas de Horacio que Filinto Elísio tradujo y que junto a las odas de su autoría componen el mayor corpus de odas producidas en el Siglo de las Luces. El estudio de traducción llevado a cabo se ancló en el referencial teórico encontrado en los escritos de Henri Meschonnic, Haroldo de Campos y Antony Pym. Evidentemente, el estudio propuesto no se limitó a los referenciales teóricos necesarios para el desvelamiento de la práctica traductora del poeta luso sin antes se rescatar el peso de sus ideas estéticas, del contexto histórico-artístico en que se inserta y de la recepción de sus ideas y obras en la historia de la literatura portuguesa. Al final del trabajo se concluye que la creación artística prolífica de los poetas neoclásicos, particularmente en la obra de Filinto Elísio, se debe al estudio y traducción – etapa fundamental – de las Odas horacianas, tomadas como matriz del género y sinónimo de buen gusto en el contexto intelectual del siglo XVIII.

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Rosé, Isabelle. « Construire une société seigneuriale : itinéraire et ecclésiologie de l'abbé Odon de Cluny ( fin du IXe-milieu du Xe siècle) / ». Turnhout : Brepols, 2008. http://opac.nebis.ch/cgi-bin/showAbstract.pl?u20=9782503518350.

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"...version de la thèse de doctorat... réalisée et soutenue en 2005 à l'Université de Nice, sous le titre "Odon de Cluny (vers 879-942). Itinéraire d'un abbé réformateur entre aristocratie carolingienne et monde féodal."
Index des noms de lieux et de personnes. Bibliographie: p. 641-706.

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Plus de sources

Livres sur le sujet "OdV"

Malutzki, Peter, 1951- book artist, dir. Oda al mar : Ode to the sea = Ode an das Meer. [Flörsheim am Main : Peter Malutzki, 2020.

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Oda a la tipografía : Ode to typography. Berkeley : Peter Koch, 1998.

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Michael, Farrell. Ode ode. Applecross, W.A : Salt, 2002.

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Ody. Sopot : Tow. Przyjaciół Sopotu, 2009.

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Averint︠s︡ev, S. S. (Sergeĭ Sergeevich), 1937-2004 et Kharlamov S. M, dir. Ody. Leningrad : Lenizdat, 1985.

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Odd. New York, NY : Samuel French, 2009.

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Mirella, D'Ettorre, dir. Odi. Pisa : Fabrizio Serra editore, 2013.

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Andreas, Kalvos. Odi. Palermo : [Università di Palermo, Istituto di filologia greca], 1988.

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Oda. Buenos Aires : Libros de Tierra Firme, 2003.

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Fontanella, Girolamo. Ode. San Mauro Torinese : Edizioni RES, 1994.

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Chapitres de livres sur le sujet "OdV"

Wijnants, Maarten, Kris Van Erum, Peter Quax et Wim Lamotte. « Augmented ODV : Web-Driven Annotation and Interactivity Enhancement of 360 Degree Video in Both 2D and 3D ». Dans Lecture Notes in Business Information Processing, 47–69. Cham : Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-30996-5_3.

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VanderHeiden, Todd F., Philip F. Stahel, Stuart L. Goldstein, Aditya Uppalapati, John A. Kellum, Aditya Uppalapati, John A. Kellum et al. « ODM ». Dans Encyclopedia of Intensive Care Medicine, 1615. Berlin, Heidelberg : Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-00418-6_1978.

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Davies, Ben, Lizzie Ostrom, Mark Morgan et Simon Levi. « Ode ». Dans Designed Technologies for Healthy Aging, 54–57. Cham : Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-031-01598-4_13.

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Cain, Tom, et Ruth Connolly. « Ode ». Dans The Poems of Ben Jonson, 54–56. London : Routledge, 2021. http://dx.doi.org/10.4324/9781315696195-11.

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Zhang, David, Xiao-Yuan Jing et Jian Yang. « Statistical Uncorrelation Analysis ». Dans Computational Intelligence and its Applications, 139–55. IGI Global, 2006. http://dx.doi.org/10.4018/978-1-59140-830-7.ch005.

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This chapter shows a special LDA approach called optimal discrimination vectors (ODV), which requires that every discrimination vector satisfy the Fisher criterion. After introduction, we first give some basic definitions. Then, uncorrelated optimal discrimination vectors (UODV) are proposed. Next, we introduce an improved UODV approach, and offer some experiments and analysis. Finally, we summarize some useful conclusions.

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M. Khalid, Garba, et Francesca Selmin. « Applications of Alginates in the Design and Preparation of Orodispersible Dosage Forms ». Dans Properties and Applications of Alginates [Working Title]. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.98610.

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Orodispersible dosage forms are attractive and innovative drug delivery systems that can fulfill individual patient needs, especially in children, elderly and among dysphagic patients. Indeed, they rapidly disperse in the mouth upon contact with the saliva without the need for water or munching. Examples of such dosage forms include orodispersible tablets (ODT), and orodispersible films (ODF). The ability to obtain ODF with different dimensions (sizes and thicknesses) makes them a suitable for personalized dosing of single or a fixed-dose combination of drugs in special patient populations. Several biopolymers are currently being exploited in the development of orodispersible dosage forms including alginates due to their versatility, availability, naturally occurring, and biosafety profile. This chapter provides an appraisal on the various applications of alginates in the preparations and their role on the properties of orodispersible dosage forms and highlights future perspectives of this very versatile biopolymer for these innovative drug delivery systems.

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« Ode Settings (Ode 1 – Ode 42) ». Dans Epitome musical, 407–35. Turnhout : Brepols Publishers, 2019. http://dx.doi.org/10.1484/m.em-eb.4.2018007.

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« ODE 17 – ODE 23 ». Dans The Odes of Solomon, 130–82. Göttingen : Vandenhoeck & Ruprecht, 1991. http://dx.doi.org/10.13109/9783666539213.130.

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« (ODE 1) – ODE 8 ». Dans The Odes of Solomon, 15–72. Göttingen : Vandenhoeck & Ruprecht, 1991. http://dx.doi.org/10.13109/9783666539213.15.

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« ODE 24 – ODE 32 ». Dans The Odes of Solomon, 183–232. Göttingen : Vandenhoeck & Ruprecht, 1991. http://dx.doi.org/10.13109/9783666539213.183.

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Actes de conférences sur le sujet "OdV"

Ingerov, Andrey, Alexey Khaliulin, Eugeny Godin, Elena Zhuk, Elena Isaeva, Isaac Gertman, George Zodiatis et Andreas Nikolaidis. « PERSEUS ODV QC software ». Dans Fourth International Conference on Remote Sensing and Geoinformation of the Environment, sous la direction de Kyriacos Themistocleous, Diofantos G. Hadjimitsis, Silas Michaelides et Giorgos Papadavid. SPIE, 2016. http://dx.doi.org/10.1117/12.2241647.

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Rich, Shayne C., Carl G. Wood et Jared Keller. « ODV mobility enhancement using active height control ». Dans AeroSense 2000, sous la direction de Grant R. Gerhart, Robert W. Gunderson et Chuck M. Shoemaker. SPIE, 2000. http://dx.doi.org/10.1117/12.391623.

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Davidson, Morgan E., Vikas Bahl et Carl G. Wood. « Utah State University's T2 ODV mobility analysis ». Dans AeroSense 2000, sous la direction de Grant R. Gerhart, Robert W. Gunderson et Chuck M. Shoemaker. SPIE, 2000. http://dx.doi.org/10.1117/12.391619.

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Arthi J., Nanthini R., Sridevi S. et VicterPaul P. « Enhanced ODV based population seeding technique for ATSP ». Dans 2015 International Conference on Innovations in Information,Embedded and Communication Systems (ICIIECS). IEEE, 2015. http://dx.doi.org/10.1109/iciiecs.2015.7193041.

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Hao, Chengpeng, Long Cai et Mojiang Chen. « Distributed ODV-CFAR Detection Based on Fuzzy Logic ». Dans 2009 International Workshop on Intelligent Systems and Applications. IEEE, 2009. http://dx.doi.org/10.1109/iwisa.2009.5072836.

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Robinson, D. Reed, et Carl G. Wood. « Stair-climbing capabilities of USU's T3 ODV mobile robot ». Dans Aerospace/Defense Sensing, Simulation, and Controls, sous la direction de Grant R. Gerhart et Chuck M. Shoemaker. SPIE, 2001. http://dx.doi.org/10.1117/12.440006.

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Strohm, Eric M., Min Rui, Michael C. Kolios, Ivan Gorelikov et Naomi Matsuura. « Optical droplet vaporization (ODV) : Photoacoustic characterization of perfluorocarbon droplets ». Dans 2010 IEEE Ultrasonics Symposium (IUS). IEEE, 2010. http://dx.doi.org/10.1109/ultsym.2010.5935474.

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Ramachandiran, R., R. Ramapraba et Joseph K. Suresh. « Multi Depot Vehicle Routing Problem using ODV EV Based Genetic Algorithm ». Dans 2019 IEEE International Conference on System, Computation, Automation and Networking (ICSCAN). IEEE, 2019. http://dx.doi.org/10.1109/icscan.2019.8878869.

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Song, Zhen, Kevin L. Moore, YangQuan Chen et Vikas Bahl. « Two-dimensional laser servoing for precision motion control of an ODV robotic license plate recognition system ». Dans AeroSense 2003, sous la direction de Grant R. Gerhart, Charles M. Shoemaker et Douglas W. Gage. SPIE, 2003. http://dx.doi.org/10.1117/12.485692.

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Witus, Gary. « Mobility potential of a robotic six-wheeled omnidirectional drive vehicle (ODV) with z-axis and tire inflation control ». Dans AeroSense 2000, sous la direction de Grant R. Gerhart, Robert W. Gunderson et Chuck M. Shoemaker. SPIE, 2000. http://dx.doi.org/10.1117/12.391620.

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Rapports d'organisations sur le sujet "OdV"

Hoff, R. W. Survey of odd-odd deformed nuclear spectroscopy. Office of Scientific and Technical Information (OSTI), septembre 1993. http://dx.doi.org/10.2172/10125318.

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Wright, I. G., B. A. Pint, P. F. Tortorelli et E. K. Ohriner. ODS iron aluminides. Office of Scientific and Technical Information (OSTI), juin 1996. http://dx.doi.org/10.2172/450767.

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Wright, I. G., C. G. McKamey et B. A. Pint. ODS iron aluminides. Office of Scientific and Technical Information (OSTI), juin 1995. http://dx.doi.org/10.2172/115408.

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Wright, I. G., C. G. McKamey et B. A. Pint. ODS iron aluminides. Office of Scientific and Technical Information (OSTI), juillet 1995. http://dx.doi.org/10.2172/106569.

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Gamache, Ken. Oceanographic DataLink (ODL). Fort Belvoir, VA : Defense Technical Information Center, août 2002. http://dx.doi.org/10.21236/ada627207.

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Fischer, S., M. P. Carpenter et R. V. F. Janssens. Superdeformation studies in the odd-odd nucleus {sup 192}Tl. Office of Scientific and Technical Information (OSTI), août 1995. http://dx.doi.org/10.2172/166319.

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Xu, Peng. The Odd Power of Dispersion. Office of Scientific and Technical Information (OSTI), décembre 2014. http://dx.doi.org/10.2172/1226559.

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Skone, Timothy J. ORV CBTL Plant Operation Princeton. Office of Scientific and Technical Information (OSTI), octobre 2013. http://dx.doi.org/10.2172/1509436.

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Camps Mirabet, Núria, et Joan Pere Enciso Rodríguez. COVID-19 i els ODS. Edicions i Publicacions de la UdL, 2020. http://dx.doi.org/10.21001/zoom.interdisciplinari.2020.1.03.

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Michael, J. D0 Clean Room ODH Analysis. Office of Scientific and Technical Information (OSTI), mai 1990. http://dx.doi.org/10.2172/1031842.

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