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Diriwari, Peremobowei Iyanu. « Resonance Energy Transfer within and to optical Nanoparticles for Bioimaging and Biosensing Applications ». Electronic Thesis or Diss., Normandie, 2024. http://www.theses.fr/2024NORMR007.
Texte intégralFluorescence-based biosensing and bioimaging play crucial roles in developing rapid and highly sensitive diagnostic tools for early detection of diseases and effective point-of-care medicine. However, these techniques require some optimisation to attain high-resolution images and very low detection limits. This thesis focuses on utilising luminescent nanoparticles and Resonance energy transfer mechanisms for advanced bioimaging and biosensing applications. I present the spectroscopic analyses of bright polymer encapsulated gold nanoclusters (AuNC-NPs) suitable for bioimaging in the shortwave infrared (SWIR) region. My study of the two photoluminescence lifetimes commonly measured in AuNCs allowed me to gather new insight to understand the origin of their luminescence. I discovered that each of these lifetimes are not sensitive in the same way to homo FRET suggesting that they originate from distinct mechanisms and distinct parts of the AuNCs such as the gold thiolate surface or the core of the nano-object. I have also characterised a new family of terbium complexes from CoraFluor (CRF) with several spectroscopic methods. I have found that they are a suitable energy transfer donor for FRET and NSET biosensing applications with gold nanoparticles. I attained sub-nanomolar limits of detection of quantum dots and have applied the system to detect the epidermal growth factor receptor (EGFR). This thesis describes the pivotal role of RET mechanisms, particularly FRET, in advancing fluorescence-based biosensing and bioimaging technologies. With innovative nanoparticle designs and strategic use of Corafluor Tb complexes, the study aims to enhance the bioimaging resolution in the SWIR region and improve diagnostic tool sensitivity, specificity and applicability, contributing to advancing precision medicine and disease management
Viana, Rodrigo Sartorelo Salemi. « Espectrometria e reconstrução de imagens tomográficas de emissão estimulada por nêutrons via algoritmo EM e método de Monte Carlo ». Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/85/85133/tde-26052014-130835/.
Texte intégralThe NSECT figures as a new spectrographic technique able to evaluate in vivo the concentration of elements using the inelastic scattering reaction (n,n). Since its introduction, several improvements have been proposed with the aim of investigating applications for clinical diagnosis and reduction of absorbed dose associated with CT acquisition. In this context, two new diagnostic applications are presented using spectroscopic and tomographic approaches from NSECT. A new methodology has also been proposed to optimize the sinogram sampling that is directly related to the quality of the reconstruction by the irradiation protocol. The studies were developed based on simulations with MCNP5 code. Diagnosis of Renal Cell Carcinoma (RCC) and the detection of breast microcalcifications were evaluated in studies conducted using a human phantom. The obtained results demonstrate the ability of the NSECT technique to detect changes in the composition of the modeled tissues as a function of the development of evaluated pathologies. The proposed method for optimizing sinograms was able to analytically simulate the composition of the irradiated medium allowing the assessment of quality of reconstruction and effective dose in terms of the sampling rate. However, future research must be conducted to quantify the sensitivity of detection according to the selected elements.
Yaringaño, Malpartida Paul Erick. « Ejecución de pruebas funcionales para certificar la aplicación NSAT (INTERBANK) ». Bachelor's thesis, Universidad Nacional Mayor de San Marcos, 2018. https://hdl.handle.net/20.500.12672/10197.
Texte intégralTrabajo de suficiencia profesional
De, La Torre Sousa César Augusto, Navarro Catherine Vanessa Figueroa, Rios Carlos Flavio Huamaní et Rodríguez César Oswaldo Ramírez. « Factores críticos del sector inmobiliario para incursionar del NSE A y B al NSE C y D de Lima Metropolitana ». Master's thesis, Pontificia Universidad Católica del Perú, 2013. http://tesis.pucp.edu.pe/repositorio/handle/123456789/8696.
Texte intégralLa investigación se centra en conocer los factores críticos para incursionar en el sector inmobiliario con departamentos en los niveles socioeconómicos (NSE) C y D para que promotores-constructores de pequeñas empresas de Lima Metropolitana, quienes actualmente construyen para los NSE A y B, puedan enfocar sus ventas en dichos niveles socioeconómicos. El conocimiento de los factores críticos, la identificación del tipo de mindset de un grupo de promotores-constructores entrevistados de pequeñas empresas y la propuesta de un tipo de departamento para incursionar en sectores populares ayudarán a solucionar en parte la problemática de aquellos promotores-constructores que no pueden dirigirse a los NSE C y D con proyectos masivos, permitiendo que estas empresas tengan mayores posibilidades de ampliar sus mercados y aprovechar las oportunidades que presenta la coyuntura inmobiliaria donde la demanda de viviendas en dicho sector sigue creciendo y la oferta actual no es suficiente. La investigación es del tipo exploratorio y ha utilizado un enfoque cualitativo. La muestra de promotores-constructores fue no probabilística, bajo el tipo experto y homogéneo. Los datos fueron recolectados de entrevistas en profundidad con una guía de preguntas que se indican en el capítulo 3. Las respuestas han sido grabadas y transcritas con la autorización de los entrevistados. Para procesar la información, se usó como herramienta el software Atlas TI, el cual permitió agrupar las respuestas de cada entrevistado ordenándolas de acuerdo con la antigüedad en el negocio. Los resultados indican que los factores críticos son cinco: parámetros urbanísticos del distrito, respaldo económico, importancia en la compra del terreno, optimización de los costos en la construcción y experiencia del promotor. Asimismo, se infiere que el tipo de mindset predominante en el grupo de promotores-constructores entrevistados es del tipo no empresarial, constringente y colectivo. III A partir de estos resultados, se construye un gráfico (mapa mental) de la relación entre los factores críticos y el tipo de mindset, para luego generar cuatro proposiciones que explica la relación del factor parámetros urbanísticos con el tipo de mindset fixed. Asimismo, el de los factores respaldo económico, compra de terreno y experiencia del promotor con el tipo de mindset constringente, y el del factor optimizar costos en construir con el tipo de mindset no empresarial. Sobre la alternativa de un tipo de departamento para incursionar en los NSE C y D en forma no masiva, se propone departamentos tipo loft, al ser un ambiente con pocos muros y espacios integrados de acuerdo con lo mencionado en el capítulo 2. El loft permite optimizar los costos de construcción, que es uno de los factores críticos identificados. Esta propuesta de vivienda puede dirigirse a los siguientes grupos sociales de los NSE C y D: (a) jóvenes profesionales y estudiantes universitarios; (b) personas con estilo de vida del tipo emprendedores y sensoriales, seleccionado de Arellano (2003); (c) hogares con pocos integrantes como los del tipo partida, tipo inicio y tipo fuera de ciclo, tomado de Ipsos Apoyo (2012); y (d) inversionistas. Las ventajas de ofrecer departamentos tipo loft para los NSE C y D son: (a) ampliación del negocio, al captar un público objetivo cuya demanda de vivienda no es atendida; y (b) al ser un departamento de transición, se podría construir mayor número de ambientes de uno o dos dormitorios para un público objetivo específico
The research is focused on identifying the critical factors to invest in real estate with apartments designed for socioeconomic status C and D so order that the developers-builders, which belong to small companies of Lima Metropolitan, who currently build for socioeconomic status A and B wil focus their sales in socioeconomic status C and D. Identifying the critical factors, finding the type of mindset of the group of developersbuilders, which compose the research sample, and proposing a type of housing, mainly apartments, to move into popular sectors, will help party to solve the problems of those developers-builders who currently can not address the socioeconomic status C and D with massive projects, allowing these companies to have greater opportunities to expand their markets and take advantage of opportunities presented by the real estate situation where the demand for housing in said sectors continues to grow and the current supply is not sufficient. The research is exploratory and uses a qualitative approach. The developers-builders sample was not random under the expert and homogeneous type. Data were collected from interviews with a guide of questions listed in Chapter 3. The responses were recorded and transcribed with the permission of the interviewees. In order to process the data we used a software tool called Atlas TI which allowed us to group the responses of each interviewee according to their years of experience in the business. The results showed five critical factors: zoning parameters of the districts, economic support, importance of the land purchase, optimization of construction cost and the developer´s experience. Also, it seems that the type of mindset prevalent in the group of developers-builders is the non-business, constricting and collectivistic type. From these results we built a graphical map of the relationship between the critical factors and the type of mindset, in order to generate four proposals that will explain, for instance, the relationship among the zoning parameters of districts, the fixed mindset, the V economic support, the important of the land purchase and developer´s experience with the constricting mindset, and finally the optimization of construction cost with the non-business mindset. The type of housing proposed to venture into socioeconomic status C and D in a nonmassive way will be the loft apartment since it implies few walls and integrated spaces as mentioned in Chapter 2. The loft apartment allows optimizing construction costs, which is one of the critical factors identified. The target market for this type of housing in the socioeconomic status C and D will be: (a) young professionals and college students, (b) people with an enterprising and sensorial lifestyle, according to author Arellano (2003), (c) households with few members such as departure type, initiation type and off-cycle type, taken from Ipsos Apoyo (2012), and (d) investors. The advantages of offering loft apartments for socioeconomic status C and D are: (a) business expansion identifying a target audience whose housing demands are not satisfied, and (b) building a higher number of one or two-bedroom apartments for a specific target audience
Tesis
Krohn, Michael. « Immunhistochemische Untersuchungen mittels S100 und NSE nach Schädel-Hirn-Trauma ». Doctoral thesis, Universitätsbibliothek Leipzig, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-189289.
Texte intégralFürst, Elmar Wilhelm M. « Die neue Güternomenklatur für die Verkehrsstatistiken : NST 2007 ». STATISTIK AUSTRIA, Bundesanstalt Statistik Österreich, 2010. http://epub.wu.ac.at/5744/1/Fuerst_Verkehr_09_2010.pdf.
Texte intégralUlrich, Anett. « S100B-Protein und Neuronenspezifische Enolase bei leichten Schädel-Hirn-Verletzungen im Kindesalter ». Doctoral thesis, Universitätsbibliothek Leipzig, 2011. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-63800.
Texte intégralCHAUDHARY, VISHAL. « DERIVATIVES RESEARCH PROJECT ON INDIAN STOCKS USING VOLATILITY SKEW STUDIES ». Thesis, DELHI TECHNOLOGICAL UNIVERSITY, 2021. http://dspace.dtu.ac.in:8080/jspui/handle/repository/18396.
Texte intégralGong, Xiuqing. « PDMS based microfluidic chips and their application in material synthesis / ». View abstract or full-text, 2009. http://library.ust.hk/cgi/db/thesis.pl?NSNT%202009%20GONG.
Texte intégralXu, Wenjin. « Anomalous hall effect in ferromagnetic metallic thin films / ». View abstract or full-text, 2010. http://library.ust.hk/cgi/db/thesis.pl?NSNT%202010%20XU.
Texte intégralPeng, Suili. « Nano/micro particle-based functional composites and applications / ». View abstract or full-text, 2007. http://library.ust.hk/cgi/db/thesis.pl?NSNT%202007%20PENG.
Texte intégralKam, Chuen. « Functional study of PICK1-ICA69 complex in the golgi apparatus / ». View abstract or full-text, 2008. http://library.ust.hk/cgi/db/thesis.pl?NSNT%202008%20KAM.
Texte intégralQiu, Yongfu. « Controlled growth and characterization of one-dimensional nano-structured materials / ». View abstract or full-text, 2008. http://library.ust.hk/cgi/db/thesis.pl?NSNT%202008%20QIU.
Texte intégralLiu, Liyu. « Design and fabrication of microfluidic/microelectronic devices from nano particle based composites / ». View abstract or full-text, 2008. http://library.ust.hk/cgi/db/thesis.pl?NSNT%202008%20LIU.
Texte intégralQiu, Chunyin. « Phase slip fluctuations in low-dimensional superconductors : a numerical study using the string method / ». View abstract or full-text, 2009. http://library.ust.hk/cgi/db/thesis.pl?NSNT%202009%20QIU.
Texte intégralCheng, Chun. « Fabrication and characterization of one dimensional ZnO nanostructures / ». View abstract or full-text, 2009. http://library.ust.hk/cgi/db/thesis.pl?NSNT%202009%20CHENG.
Texte intégralHe, Xiaozhou. « Thermal dissipation field and its statistical properties in turbulent Rayleigh-Bénard convection / ». View abstract or full-text, 2009. http://library.ust.hk/cgi/db/thesis.pl?NSNT%202009%20HE.
Texte intégralFisher, Christine Marie. « Perceptions of Elementary School Children`s Parents Regarding Sexuality Education ». University of Toledo / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1404314459.
Texte intégralCortavarria, Erick, Francisco González, Akira Mejía et Alberto Romani. « Lanzamiento de alimento para bebés dirigido al NSE C "Sanitos" ». Universidad Peruana de Ciencias Aplicadas - UPC. Escuela de Postgrado, 2009. http://hdl.handle.net/10757/273874.
Texte intégralBlanchi, Véronique. « Interet diagnostique de l'enolase neuron-specifique (nse) en pathologie pleuropulmonaire ». Nice, 1988. http://www.theses.fr/1988NICE6510.
Texte intégralIdri, Amanda C. « Development of a Correlation Equation Between Shear Wave Values And NSPT Values in Northeastern Ohio ». University of Akron / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=akron1574441753941474.
Texte intégralBARJAUD, PASCAL. « Etude d'un protocole d'utilisation dans la determination de la nse et du rapport nse/nne pour le suivi des cancers anaplasiques a petites cellules du poumon ». Clermont-Ferrand 1, 1992. http://www.theses.fr/1992CLF13051.
Texte intégralGruber, Christine. « Differentialdiagnose beim Lungenkarzinom durch CEA, CYFRA 21-1, NSE und ProGRP ». Diss., lmu, 2008. http://nbn-resolving.de/urn:nbn:de:bvb:19-90260.
Texte intégralFontenoy, Claudia, Maria Ines Ortiz et Julio Santillana. « Relanzamiento y consolidación de la marca Trois en el NSE A ». Master's thesis, Universidad Peruana de Ciencias Aplicadas (UPC), 2016. http://hdl.handle.net/10757/596581.
Texte intégralZboril, Sabrina. « Diagnóstico da síndrome da disfunção cognitiva em cães idosos após procedimento cirúrgico-anestésico ». Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/10/10137/tde-16092015-112158/.
Texte intégralCognitive dysfunction is defined as changes in mental processes and it detection is performed with the aid of neuropsychological tests. Recently research has been conducted in attempt to establish early neuro biochemicals markers to estimate neuronal death. This study evaluated 24 dogs that were distributed into two groups: CG - control group (up to 8 years old) (n = 10) and EG - elderly group (over 8 years) (n = 14). All animals underwent periodontal treatment under general anesthesia and were previously evaluated to detect the presence of systemic diseases. A complete neurological and cardiac examination were performed in all animals and also a peripheral venous blood samples were collected for blood count, kidney and liver profile. The animals were assessed for cognition by using two neuropsychological scales (ARCAD and CCDR) and the assessment of serum levels of protein markers of neuronal damage (NSE and S100β) pre and postoperatively. A significant increase in S100β protein in EG compared to the CG (p = 0.014) in the preoperative period was observerd and also between the post-extubation times in the animals of CG (p = 0.04). Through behavioral scales used it was not possible to detect cognitive dysfunction in the postoperative elderly dogs underwent surgical - anesthetic procedure. The values of S100β protein suggest that elderly animals may have preoperative neuroinflammation caused by systemic or central inflammation; however we could not correlate with the behavioral scales
Sarras, Marcella. « Påverkan av hemolys vid analys av neuronspecifikt enolas på Cobas ». Thesis, Malmö universitet, Fakulteten för hälsa och samhälle (HS), 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-44406.
Texte intégralNeuron Specific Enolase (NSE) is an important biomarker for diagnosing e.g. neuroendocrine tumors, especially small cell lung cancer (SCLC) and neuroblastoma. NSE is also used as a part of the investigation of brain damage in cardiac arrest. Because NSE is present in high concentrations in erythrocytes, hemolysis in the blood sample can cause falsely elevated NSE levels in serum without brain damage. The purpose of this study was to evaluate how hemolysis affects NSE analysis on Cobas, a fully automated analytical instrument. Measurement of NSE concentration was performed on Cobas 8000 from Roche Elecsys, based on immunochemical sandwich method with ElectroChemi-Luminescence Immunoassay (ECLI) detection technique. To study the effect of hemolysis, hemolysates were prepared from 20 patient samples. These hemolysates were added to pooled serum, with NSE levels within the reference range (<17 μg/L). The degree of hemolysis was also determined on Cobas 8000. The result showed a linear relationship between the measured hemolysis index (HI) values and S-NSE values. The variation in NSE contribution at the individual level was examined with the result that each hemolysis unit corresponds to an NSE contribution of 0.33 ± 0.07 µg/L, which is released from erythrocytes. A suggestion to solve the problem of hemolysis relating to NSE analysis is to use a compensatory factor to correct the NSE concentration. Compensation can be performed by using the relationship obtained in the study (1 HI = 0.33 ± 0.07 µg/L NSE contribution) and subtracting the contribution from the measured NSE concentration.
Diaz, Smoje Mariana Andrea [Verfasser], et George [Gutachter] Coupland. « Functional characterization of NSE4 paralogs in Arabidopsis thaliana / Mariana Andrea Diaz Smoje ; Gutachter : George Coupland ». Köln : Universitäts- und Stadtbibliothek Köln, 2018. http://d-nb.info/1160379386/34.
Texte intégralSmall, Lauren. « An investigation into the function of the SUMOylation of Nse2 and PCNA in S. pombe ». Thesis, University of Sussex, 2014. http://sro.sussex.ac.uk/id/eprint/52751/.
Texte intégralRomero, Meza Verónica Patricia. « Sensibilidad materna y problemas de conducta en niños preescolares de NSE bajo ». Bachelor's thesis, Pontificia Universidad Católica del Perú, 2016. http://tesis.pucp.edu.pe/repositorio/handle/123456789/7481.
Texte intégralAinsworth and Bowlby raised that maternal sensitivity is a factor associated with the development of a secure attachment in the child, has been supported by several studies over time. In this way, the child, with a secure attachment, would be less likely to develop behavioral problems throughout his life. The present study aims to explore the relationship between maternal sensitivity and behavior problems in preschool children of low socioeconomic status belonging to Lima Metropolitana. In order to achieve this, 36 children with ages in a range of 36 to 59 months (M = 44.31 , SD = 7.09) were evaluated, as well as their mothers, whose age oscillated between 22 and 42 years (M = 28.33 , SD = 5.14). Also, to evaluate maternal sensitivity was used the Maternal Behavior for Preschooler´s Q-set (MBPQS) (Posada, Kaloustian, Richmond & Moreno, 2007) and for behavior problems the Child Behavior Check List 1.5- 5 (CBCL 1.5- 5) (Rescorla, 2005; ASEBA, 2014). The results show there were not significant relation between maternal sensitivity and behavior problems in the child. Likewise, we found one significant difference in global behavior problems in relation to the sex of the child, where boys tend to have greater problems of conduct than girls. Moreover, the externalizing scale was shown that boys are more likely to develop this kind of problems than girls, showing no significant difference in internalizing scale.
Tesis
Toledo, Flavia Dutra de. « Biomarcadores de lesão cerebral em pacientes idosos submetidos à anestesia subaracnoidea para tratamento de fraturas de fêmur ». Universidade Estadual Paulista (UNESP), 2018. http://hdl.handle.net/11449/157335.
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Introdução: A última atualização demográfica do Instituto Brasileiro de Geografia e Estatística realizada em 2017 mostrou que a população acima de 60 anos representava 14,6% dos 207,1 milhões de habitantes do Brasil, o que corresponde a aproximadamente 30 milhões de idosos, com expectativa de vida de 75,8 anos. Entre 2007 e 2011, o número acumulado de internações por fraturas de fêmur em pacientes acima de 60 anos, nos hospitais do Sistema Único de Saúde, foi de 175.781 O delirium pós-operatório é uma complicação comum nos pacientes idosos, e está associado a hospitalizações prolongadas, maiores taxas de institucionalização após a alta, deterioração cognitiva prolongada, diminuição da capacidade funcional, além de ser fator independente de mortalidade em 6-12 meses. Estudo disponível na literatura mostra que 14 a 24% dos pacientes idosos com fratura de quadril apresentam delirium já na admissão hospitalar, sendo que a prevalência durante a internação chega a 56%. Os mecanismos fisiopatológicos do desenvolvimento do delirium pós-operatório (DPO) e do déficit cognitivo pós-operatório têm sido estudados em nível molecular, porém ainda com pouco ganho. Maiores esforços de pesquisa são colocados na identificação de biomarcadores diagnósticos e prognósticos que estejam relacionados com mecanismos moleculares que levam ao DPO. Objetivos: Primariamente, relacionar os níveis séricos de dois biomarcadores de neuroinflamação (S100B e enolase neurônio-específica) com a ocorrência de delirium pré e pós-operatório em pacientes idosos submetidos a cirurgias de correção de fratura de quadril (fêmur proximal). Como objetivo secundário, foi proposto avaliar a influência dos fatores sexo, hipotensão perioperatória, classificação de risco anestésico ASA, uso de fármacos anestésicos para sedação (midazolam e fentanil), além de duração e tipo de cirurgia realizada (artroplastia de quadril ou osteossíntese de fêmur) sobre os níveis dos biomarcadores. Métodos: Foi realizado estudo clínico observacional prospectivo com pacientes acima de 60 anos internados no HCFMB para correção de fratura de quadril (terço proximal do fêmur) no período de maio de 2017 a abril de 2018; todos os pacientes assinaram o Termo de Consentimento Livre e Esclarecido. Os pacientes foram avaliados em dois momentos: dentro das 24 horas que antecederam a cirurgia (M1) e, novamente, 24 horas após o final da cirurgia (M2). Em cada momento, foi realizado o diagnóstico de presença ou ausência de delirium por meio da escala CAM (Confusion Assessment Method), instrumento validado em Português, e foram coletadas amostras de sangue para dosagem de S100B e Enolase plasmáticos. As dosagens dos biomarcadores foram realizadas por método ELISA. Resultados: Dos 42 pacientes analisados, 33 eram do sexo feminino e 9 do sexo masculino (78,57% e 21,4%, respectivamente), com idade média de 71,97 ± 8,68 anos. Delirium ocorreu em 11,9% dos pacientes em M1 e 16,7% em M2. Não houve variação dos níveis médios de S100B entre pacientes com e sem delirium, nem dentro do mesmo momento, quanto de um momento para outro (p=0,12). Os valores médios de NSE foram estatisticamente diferentes quando comparados os pacientes sem delirium pré-operatório e aqueles com delirium pós-operatório (p=0,002); entretanto, pacientes que não tiveram delirium em qualquer momento também apresentaram variação significante do marcador entre M1 e M2 (p=0,004). Ainda, pacientes com delirium pós-operatório tiveram níveis mais altos de NSE dosados em M2 (p=0,02). Mulheres apresentaram maiores níveis de S100B (p=0,03), enquanto as médias de NSE foram maiores entre homens (p=0,04). Não houve influência da classificação ASA tanto nos níveis de S100B quanto de NSE (p=0,67 e p=0,12, respectivamente). Níveis mais altos de S100B foram verificados em pacientes que apresentaram algum episódio de hipotensão perioperatória (p=0,035), porém não houve relação entre este último evento e a ocorrência de delirium pós-operatório (p=0,65). Quanto ao uso de sedação intraoperatória, doses maiores de midazolam foram administradas aos pacientes que não desenvolveram DPO (p=0,001), enquanto as doses de fentanil não diferiram entre pacientes com e sem DPO (p=0,21). Não houve relação entre o tipo de procedimento cirúrgico executado e duração média da cirurgia (p=0,89 e p=0,15, respectivamente) com a ocorrência de DPO. Conclusões: Não foi encontrada associação entres os níveis do marcador S100B e a presença de delirium em qualquer momento; entretanto, níveis pré-operatórios aumentados de NSE foram relacionados à ocorrência de delirium pós-operatório. Pacientes com episódios de hipotensão perioperatória apresentaram níveis mais altos de S100B na avaliação pós-operatória. São necessárias investigações futuras quanto ao nível de expressão destas proteínas por outros tecidos e se existem outras vias de sinalização celular ainda desconhecidas, para que assim possamos entender melhor o comportamento destes biomarcadores e a sua relação com a patogênese do delirium.
Background: According to the latest census from IBGE (Instituto Brasileiro de Geografia e Estatística), population over 60 years-old accounted for 14,3% of a total 204,9 million habitants in Brazil. From 2007 to 2011, 175.781 elder patients were admitted after a hip fracture in brazilian public hospitals. Post-operative delirium (POD) is an usual complication in the elderly and is associated to longer hospital stay, cognitive impairment, functional decline and increased 6-12 months mortality rate. Delirium rates between the elder population can be as high as 14 to 24% already at admission, being the prevalence as high as 56% during hospital stay. Pathophysiologic mechanisms of delirium have been studied at molecular level, but research efforts are still needed in order to develop sensitive and specific early markers for this condition, so that diagnosis and effective treatment would be readily given. Objectives: This research project aims to correlate two neuroinflamation biomarkers serum levels (S100B protein and Neuron Specific Enolase - NSE) and the incidence of pre and postoperative delirium in elderly patients undergoing hip fracture repair. Also, we intent to evaluate how gender, ASA Physical Status classification and perioperative hypotension may contribute to changes in the levels of these biomarkers. Methods: An observational prospective study was proposed envolving patients aged 60 or more who were admitted at Clinics Hospital of Botucatu Medical School (Botucatu, São Paulo, Brazil) for hip fracture repair, from May, 2017 to April, 2018. All patients signed the Informed Consent. The CAM (Confusion Assessment Method) short scale was used to assess the presence of delirium first at admission and again, 24 hours after surgery. Blood samples were also collected at two moments, by the patient’s admission to the operating room and then 24 hours after surgery, to assess NSE and S100B plasmatic levels. S100B and NSE levels were measured on the Synergy HT Biotec analyzer using ELISA technique (Elabscience ® kits). Results: Of 42 patients included, 33 were female and 9 male (78.57% vs 21.4%), with mean age of 71.97 ± SD 8.68 years). Delirium occurred in 11.9% of patients at M1 and 16.7% at M2. S100B mean levels did not significantly change between patients with and without delirium, neither at the same moment (p=0.95 and p=0.96, respectively) nor from M1 to M2 (p=0,12). NSE levels in delirious and non-delirious patients at M1 were elevated at M2 (p=0.04); however, higher NSE levels at M1 were significantly related to emergence of delirium at M2 (p=0.002). Moreover, despite of the fact that NSE levels increased at M2 in patients without delirium (p=0.004), delirious patients at M2 had significantly higher NSE levels (p=0.02). S100B levels were higher in female patients (p=0.03), whereas NSE was higher in male ones (p=0.04). Perioperative hypotension was linked to higher S100B levels at M2 (p=0.035), but not to postoperative delirium 9p=0,65). ASA classification had no influence on biomarkers levels. Regarding the use of intraoperative sedation, higher amounts of midazolam were administered to patients who did not further develop POD (p=0.001); fentanyl doses did not differ between patients with or without POD (p=0.21). Surgical technique (hip replacement or osteosynthesis) and surgery duration had no influence on POD occurrence (p=0.89 and p=0.15, respectively). Conclusions: No association was found between S100B levels and delirium, but increased preoperative NSE levels were related to emergence of postoperative delirium. Patients with records showing episodes of perioperative hypotension had higher postoperative levels of S100B. Further investigation of yet unidentified tissue expression and signaling pathways of these proteins are needed in order for them to be used as predictors of delirium in clinical practice.
Skilton, Andrew Michael. « Investigation of SUMO phosphorylation and analysis of selected targets of the two sumo ligases NSE2 and PLI1 ». Thesis, University of Sussex, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.496854.
Texte intégralZelkowski, Mateusz [Verfasser]. « Arabidopsis NSE4 proteins act in somatic nuclei and meiosis to ensure plant viability and fertility / Mateusz Zelkowski ». Halle, 2019. http://d-nb.info/117779859X/34.
Texte intégralApostolova, Sonia. « The RING domain of Nse1 : roles in Smc5/6 complex stability and genome integrity in human cells ». Doctoral thesis, Universitat de Lleida, 2021. http://hdl.handle.net/10803/672395.
Texte intégralEl complejo Smc5/6, es uno de los tres complejos de mantenimiento de la estructura de los cromosomas (Structural Maintenance of Chromosomes, SMC). En esta tesis se muestra que el dominio RING de la subunidad Nse1 del complejo Smc5/6, tiene un papel crucial en el mantenimiento de la estabilidad genómica en células humanas. Mediante CRISPR-Cas9 hemos creado mutantes estables de NSE1 en el dominio RING C-terminal, en células HEK293T. En estos mutantes no se detecta la proteína Nse1, ni otras subunidades del complejo. Además, presentan un fenotipo de inestabilidad genómica, caracterizado por un crecimiento lento, mitosis más prolongadas, daño endógeno en el ADN, ralentización en la progresión de las horquillas de replicación y sensibilidad a el agente genotóxico MMS. Estos resultados sugieren que los mutantes en NSE1 entran en mitosis con la presencia de zonas del DNA no replicadas o con estructuras de recombinación no resueltas, que llevan a la rotura de cromosomas y a inestabilidad genómica en la siguiente generación.
The Smc5/6 complex is one of the three Structural Maintenance of Chromosomes (SMC) complexes. This thesis shows that the RING domain of the Nse1 subunit of the Smc5/6 complex plays a crucial role in maintaining genomic stability in human cells. Using CRISPR-Cas9 we created stable mutants of NSE1 in the C-terminal RING domain, in HEK293T cells. Nse1 protein and other subunits of the complex are not detected in these mutants. In addition, they present a phenotype of genomic instability, characterized by slow growth, prolonged mitosis, endogenous DNA damage, slowing in the progression of replication forks and sensitivity to the genotoxic agent MMS. These results suggest that mutants in NSE1 enter mitosis with the presence of unreplicated DNA regions or with unresolved recombination structures, leading to chromosome breakage and genomic instability, in the next generation.
Zhang, Zhihan. « NSEA : n-Node Subnetwork Enumeration Algorithm Identifies Lower Grade Glioma Subtypes with Altered Subnetworks and Distinct Prognostics ». Case Western Reserve University School of Graduate Studies / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=case148595901371196.
Texte intégralStoll, Alexander. « Neurologische Komplikationen nach Herzoperationen unter der Berücksichtigung der Hypoxiemarker NSE und Protein S100 / ». Hamburg : Akademos Wiss.-Verl, 2003. http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&doc_number=010456703&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA.
Texte intégralMossberg, Zimon. « Achieving Automatic Speech Recognition for Swedish using the Kaldi toolkit ». Thesis, KTH, Skolan för datavetenskap och kommunikation (CSC), 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-194178.
Texte intégralEn taligenkännare för svenska utvecklas med målet att utvärdera hur en taligenkännareutvecklad med fritt tillgängliga verktyg står sig mot kommersiella taligenkänningstjänster.Verktyget som används är det öppna källkodsverktyget Kaldi och som träningsdataanvänds det offentligt tillgängliga talkorpuset för svenska från NST. De framtagna mod-ellerna jämförs mot kommersielt tillgängliga tjänster för taligenkänning på svenska.Tidiga resultat i jämförelsen indikerar ett systemiskt jäv i den valda testdata, vilketbekräftas av en uppföljande undersökande utvärdering. Slutsatsen av arbetet är attutsikterna att ta fram en taligenkännare för svenska är goda men kräver omfattandearbete.
Rojas, Parco Frank Gabriel, et Ortiz Jhow Mckevin Zamora. « Correlación de los valores Nspt con Ndpl en los suelos arenosos de la Asociación Agropecuaria Sumac Pacha - Lurin ». Bachelor's thesis, Universidad Ricardo Palma, 2015. http://cybertesis.urp.edu.pe/handle/urp/1252.
Texte intégralGönner, Svenja Lara [Verfasser]. « Charakteristika und Outcome nach Implantation bioresorbierbarer Scaffolds bei Patienten mit NSTE-ACE nach 3 Jahren / Svenja Lara Gönner ». Mainz : Universitätsbibliothek der Johannes Gutenberg-Universität Mainz, 2021. http://d-nb.info/1238223869/34.
Texte intégralAlfaro, Prieto Gladys Consuelo. « Sensibilidad materna y apoyo social percibido en madres de niños preescolares de NSE bajo ». Bachelor's thesis, Pontificia Universidad Católica del Perú, 2017. http://tesis.pucp.edu.pe/repositorio/handle/123456789/9386.
Texte intégralThe research aims at exploring the relationship between maternal sensitivity and perceived social support in mothers of pre-school children of low socioeconomic status. Twenty-nine mothers between the ages of 23 and 44 (M = 29.57, SD = 5.65), whose children were between 49 and 73 months of age (M = 57, SD = 6.87). This study used the Maternal Behavior for Preschoolers' Q-Set (Posada, Moreno, & Richmond, 1998) in observation mode, and the Social Support Medical Outcomes Questionnaire (Sherbourne & Stewart, 1991) validated in Spanish by Rodríguez and Enrique (2007). The results showed a significant and positive association of medium magnitude between instrumental type social support and the overall level of maternal sensitivity, as well as with the scale supervision and monitoring and safe base support. A specific objective was to describe maternal sensitivity, which was found a low level in her grades, as well as a negative correlation of marginal significance with the mother's age. Regarding the second specific objective, the social support was described and it was identified that the instrumental support is the one that is perceived in a smaller proportion than the other types of support, besides finding differences in the level of support according to the family structure of the mother. These findings indicate that in contexts of poverty, as mothers perceive behavioral and material assistance in the care of their preschool child and in their daily tasks, they tend to be more sensitive in parenting.
Tesis
Quantin, Xavier. « Intérêt pronostic de la NSE sérique pour le cancer bronchique non à petites cellules ». Montpellier 1, 1995. http://www.theses.fr/1995MON11020.
Texte intégralDiyaolu, Olamilekan Olawale. « Workers’ compensation insurance and IFRS17 non-similar to life techniques with focus on risk adjustment ». Master's thesis, Instituto Superior de Economia e Gestão, 2021. http://hdl.handle.net/10400.5/22776.
Texte intégralThe need for global comparability, recognition, measurement, presentation, and disclosure of insurance contracts gave birth to IFRS17. IFRS17 marks a new era for insurance contract accounting. This work brings forward the impact of IFRS17 on the Workers Compensation line of business (WC LoB). Liabilities in the WC LoB can be of a very different nature, namely workers compensatio insurance using non-similar to life techniques and annuities originating from non-life insurance contracts and relating to health insurance obligations that use similar to life techniques (SLT). The main focus of this paper will be on the non-similar life technique as this is the very specificity of the Portuguese insurance market. The report will present the basic measurement approaches with more focus on the Premium Allocation Approach (PAA) under the standard. The structure of the report resumes the analysis of the impact of IFRS17 on Workers Compensation by considering the disaggregation into non-similar and similar to life techniques i.e., claims arising from the WC LoB are divided into two types. The Addactis IBNRS software will be used in the analysis of this report. This is dedicated software for the non-life type of claims reserving.
info:eu-repo/semantics/publishedVersion
Elias, Bruno Cesar. « Comparação dos valores séricos de enolase neuronal específica (NSE) em cães com e sem encefalite ». Universidade Estadual de Londrina. Centro de Ciências Agrárias. Programa de Pós-Graduação em Ciência Animal, 2016. http://www.bibliotecadigital.uel.br/document/?code=vtls000205310.
Texte intégralThe use of biomarkers in human and veterinary medicine is important to help the clinical management. Regarding to this, the specific neuronal enolase (NSE) is a biomarker resultant of the neuronal cell lysis, which demonstrate stability in extracellular fluids such as blood and cerebrospinal fluid. In human clinical researchs, was observed reliability in serum samples to distinguish and estimate the central nervous system damage in cases of encephalitis. In veterinary medicine, there are no studies evaluating the expression of NSE in serum samples from dogs with encephalitis. Thus, the objectives of this study was to compare the values of serum NSE in healty dogs and dogs with encephalitis and to evaluate theefficacy of the ELISA test using human antibodies in the detection of biomarker. For this, we used 38 dogs in total, divided into two groups, 19 dogs with encephalitis (GE) and 19 dogs without encephalitis (GS). The criteria for inclusion in to the GS were aged 1 to 7 years, with normal clinical and laboratory tests. For the GE inclusion, criteria were dogs with neurological signs brain injury, positive molecular diagnosis for distemper, and no signs of hemolysis. Regarding the results obtained it was found that for the GE serum NSE values higher with greater variation, and higher mean and median GS, there was a significant difference between the groups (p = 0.0053). In the serum samples tested, the NSE was effectivelly measured, demonstrating the feasibility of ELISA ?using human antibodies. Conclusions: in dogs with encephalitis the NSE values werer higher when compared to dogs without encephalitis, presenting a significant difference between the groups and contributing to the validation of serum NSE as a biomarker; the ELISA test can be used to measure the NSE in serum samples of dogs.
Neri, Pierre. « Use of GNSS signals and their augmentations for Civil Aviation navigation during Approaches with Vertical Guidance and Precision Approaches ». Thesis, Toulouse, INPT, 2011. http://www.theses.fr/2011INPT0073/document.
Texte intégralSince many years, civil aviation has identified GNSS as an attractive mean to provide navigation services for every phase of flight due to its wide coverage area. However, to do so, GNSS has to meet relevant requirements in terms of accuracy, integrity, availability and continuity. To achieve this performance, augmentation systems have been developed to correct the GNSS signals and to monitor the quality of the received Signal-In-Space (SIS). We can distinguish GBAS (Ground Based Augmentation Systems), ABAS (Airborne Based Augmentation Systems) SBAS (Satellite Based Augmentation Systems). In this context, the aim of this study is to characterize and evaluate the GNSS position error of various positioning solutions which may fulfil applicable civil aviation requirements for GNSS approaches. In particular, this study focuses on two particular solutions which are: • Combined GPS/GALILEO receivers augmented by RAIM where RAIM is a type of ABAS augmentation. This solution is a candidate to provide a mean to conduct approaches with vertical guidance (APV I, APV II and LPV 200). • GPS L1 C/A receivers augmented by GBAS. This solution should allow to conduct precision approaches down to CAT II/III, thus providing an alternative to classical radio navigation solutions such as ILS. This study deals with the characterization of the statistics of the position error at the output of these GNSS receivers. It is organised as following. First a review of civil aviation requirements is presented. Then, the different GNSS signals structure and the associated signal processing selected are described. We only considered GPS and GALILEO constellations and concentrated on signals suitable for civil aviation receivers. The next section details the GNSS measurement models used to model the measurements made by civil aviation receivers using the previous GNSS signals. The following chapter presents the GPS/GALILEO and RAIM combination model developed as well as our conclusions on the statistics of the resulting position error. The last part depicts the GBAS NSE (Navigation System Error) model proposed in this report as well as the rationales for this model
Yildirim, Gokce. « Smoke Simulation On Programmable Graphics Hardware ». Master's thesis, METU, 2005. http://etd.lib.metu.edu.tr/upload/12606545/index.pdf.
Texte intégralRemédio, Flávio Henrique [UNESP]. « Análise de estabilidade de taludes de aterro de resíduos urbanos utilizando parâmetros geotécnicos de propostas bibliográficas e correlações com Nspt ». Universidade Estadual Paulista (UNESP), 2014. http://hdl.handle.net/11449/123741.
Texte intégralO aumento nas taxas de geração de resíduos, decorrentes do aumento das atividades industriais e do poder de compra da população, frente à escassez de áreas adequadas à disposição de resíduos, próximas aos centros geradores, tem levado as administradoras a investirem no aumento da capacidade de carga de aterros sanitários em operação ou na reutilização de antigas áreas de disposição encerradas, para suprir esta demanda. Esta situação induz a construção de aterros cada vez mais altos, atenuando o problema da demanda de resíduos e, em contrapartida, gerando grandes preocupações quanto à estabilidade destes corpos. Dentro deste contexto, os métodos convencionais de cálculo de estabilidade de taludes são comumente utilizados em estudos de estabilidade em aterros sanitários, por pesquisadores e profissionais especializados. No entanto, estas metodologias de trabalho foram desenvolvidas para estudos em maciços com constituição e comportamento mecânico distintos dos materiais dispostos em aterros sanitários. Desta forma, foram executados estudos sistemáticos com objetivo de determinar parâmetros geotécnicos adequados aos resíduos presentes no Aterro de Caetetuba, localizado no município de Atibaia - SP. Os parâmetros geotécnicos dos resíduos foram determinados com base em propostas levantadas durante a pesquisa bibliográfica e com base em resultados de testes de penetração de sondagens identificadas na pesquisa documental. Diversos métodos de análise de estabilidade de taludes, levantados durante a pesquisa bibliográfica, foram avaliados visando identificar o método mais adequado para aplicação no Aterro Sanitário de Caetetuba. Para realização das análises de estabilidade foram elaboradas seções litoconstrutivas do aterro, com base em plantas topográficas e perfis de sondagens identificados na pesquisa documental, as quais foram implementadas no software SLOPE/W da Geo-Slope International. As...
The increase in waste generation rates, due to the increase of industrial activity and the population's purchasing power, compared to the scarcity of appropriate disposition of the waste areas, close to generating centers, has led managers to invest in increasing the capacity of load landfills in operation or reuse of old disposal areas closed to meet this demand. This leads to the construction of higher and higher landfill, reducing the problem of waste demand and, in turn, generating serious concerns over the stability of these bodies developed for studies in natural massive, with constitution and mechanical behavior of different materials disposed of in landfills. In this way, systematic studies have been performed in order to determine suitable geotechnical parameters waste present in Caetetuba Landfill, located at Atibaia/SP city. The geotechnical parameters of waste were determined based on proposals raised during the literature and based on survey results of penetration tests identified in documentary research. Several methods of slope stability analysis, raised during the literature search were evaluated to identify the most suitable method for applying the landfill Caetetuba of Health. To perform the stability analysis were prepared sections of the site, based on topographic maps and profiles polls identified in documentary research, which were implemented in SLOPE / W Geo-Slope International software. The findings were expressed in terms of security values, and compared the safety factors calculated by the various methods offered by the SLOPE / W software, depending on the variations in geotechnical parameters and analytical methods used. Within this context, the conventional slope stability calculation methods developed in soil mechanics are commonly used in the stability studies in landfills, by researchers and professionals. However, these work methodologies were
Vieira, Fernando de Paula. « Critério estatístico para obtenção de valores de NSPT para previsão da capacidade de carga de estacas por métodos semi empíricos ». Universidade do Estado do Rio de Janeiro, 2015. http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=8381.
Texte intégralOne of the most challenging aspects of geotechnical engineering is the selection of soil parameters from field and / or laboratory tests to be used in analytical or numerical models for foundation design. Due to known uncertainties in SPT tests and wide availability of criteria for NSPT interpretation, a proposed procedure is presented based on 95% confidence limits around a trend line defined by simple linear regression analysis expressing the variation of NSPT with depth. The NSPT values obtained by the proposed approach have been used to estimate the pile ultimate capacity of 19 isolated continuous flight auger piles using different semi-empirical methods, such as Aoki and Velloso (1975) with modified coefficients as proposed by Monteiro (1997), Décourt and Quaresma (1978) modified by Décourt (1996) and Alonso (1996). Static load tests of the same 19 piles have been extrapolated by Van Der Veen (1953) and Décourt (1996) methods, as an aid for comparison and validation of the statistical criterion. Additionally, were made with the fulcrum in item 6.2.1.2.1 of ABNT NBR 6122: 2010 - Resistance calculated by semi-empirical method, evaluations of safety factors in relation to load project, also including the premise of recognizing representative regions and taking into account the number of SPT tests, a fact that provides the decreased uncertainty of the parameters, indicating a lower FS. The dissertation emphasizes the advantages of an adequate statistical treatment of the geotechnical data, similar to what is recommended by the Eurocode. Such approach allows and encourages a more rational decision including all interested parties - consumers, designers, inspectors, contractors and scientific community providing more objective and harmonious discussions on this subject.
Remédio, Flávio Henrique. « Análise de estabilidade de taludes de aterro de resíduos urbanos utilizando parâmetros geotécnicos de propostas bibliográficas e correlações com Nspt / ». Rio Claro, 2014. http://hdl.handle.net/11449/123741.
Texte intégralBanca: Fábio Augusto Gomes Vieira
Banca: Oswaldo Augusto Filho
Resumo: O aumento nas taxas de geração de resíduos, decorrentes do aumento das atividades industriais e do poder de compra da população, frente à escassez de áreas adequadas à disposição de resíduos, próximas aos centros geradores, tem levado as administradoras a investirem no aumento da capacidade de carga de aterros sanitários em operação ou na reutilização de antigas áreas de disposição encerradas, para suprir esta demanda. Esta situação induz a construção de aterros cada vez mais altos, atenuando o problema da demanda de resíduos e, em contrapartida, gerando grandes preocupações quanto à estabilidade destes corpos. Dentro deste contexto, os métodos convencionais de cálculo de estabilidade de taludes são comumente utilizados em estudos de estabilidade em aterros sanitários, por pesquisadores e profissionais especializados. No entanto, estas metodologias de trabalho foram desenvolvidas para estudos em maciços com constituição e comportamento mecânico distintos dos materiais dispostos em aterros sanitários. Desta forma, foram executados estudos sistemáticos com objetivo de determinar parâmetros geotécnicos adequados aos resíduos presentes no Aterro de Caetetuba, localizado no município de Atibaia - SP. Os parâmetros geotécnicos dos resíduos foram determinados com base em propostas levantadas durante a pesquisa bibliográfica e com base em resultados de testes de penetração de sondagens identificadas na pesquisa documental. Diversos métodos de análise de estabilidade de taludes, levantados durante a pesquisa bibliográfica, foram avaliados visando identificar o método mais adequado para aplicação no Aterro Sanitário de Caetetuba. Para realização das análises de estabilidade foram elaboradas seções litoconstrutivas do aterro, com base em plantas topográficas e perfis de sondagens identificados na pesquisa documental, as quais foram implementadas no software SLOPE/W da Geo-Slope International. As...
Abstract: The increase in waste generation rates, due to the increase of industrial activity and the population's purchasing power, compared to the scarcity of appropriate disposition of the waste areas, close to generating centers, has led managers to invest in increasing the capacity of load landfills in operation or reuse of old disposal areas closed to meet this demand. This leads to the construction of higher and higher landfill, reducing the problem of waste demand and, in turn, generating serious concerns over the stability of these bodies developed for studies in natural massive, with constitution and mechanical behavior of different materials disposed of in landfills. In this way, systematic studies have been performed in order to determine suitable geotechnical parameters waste present in Caetetuba Landfill, located at Atibaia/SP city. The geotechnical parameters of waste were determined based on proposals raised during the literature and based on survey results of penetration tests identified in documentary research. Several methods of slope stability analysis, raised during the literature search were evaluated to identify the most suitable method for applying the landfill Caetetuba of Health. To perform the stability analysis were prepared sections of the site, based on topographic maps and profiles polls identified in documentary research, which were implemented in SLOPE / W Geo-Slope International software. The findings were expressed in terms of security values, and compared the safety factors calculated by the various methods offered by the SLOPE / W software, depending on the variations in geotechnical parameters and analytical methods used. Within this context, the conventional slope stability calculation methods developed in soil mechanics are commonly used in the stability studies in landfills, by researchers and professionals. However, these work methodologies were
Mestre
Silva, Daniel Fermino da. « Mapeamento geoestatístico dos parâmetros Nspt e torque máximo de solos em parte da bacia do Ribeirão Cambezinho em Londrina/PR ». Universidade Estadual de Londrina. Centro de Tecnologia e Urbanismo. Programa de Pós-Graduação em Engenharia de Edificações e Saneamento, 2008. http://www.bibliotecadigital.uel.br/document/?code=vtls000149824.
Texte intégralThis study has as its objective to map the resistance geotechnical parameters of NSPT and Maximum Torque, obtained from a data bank of 238 field tests of SPT-T (Standard Penetration Test with Torque Measurement) done in the Cambezinho hydrographic creek basin, that comprehends part of urban zone of the city of Londrina/Pr and to correlate these variables to factors as topography and pedology. The experimental area has approximately 37 km². The geotechnical profile of the experimental area consists in a residual silty clay that originates from the intemperism acting on the basaltic rocks of the Serra Geral Formation. The superficial layer has a high porosity and lateritic and collapsible behavior. Through descriptive and spatial statistics tools were done the analysis, interpolation and the interpretation of the results of the field tests about the Maximum Torque and NSPT measured. Then, the results were geoprocessed and analyzed along with the natural factors explained above through altimetric and pedologic maps. In an early analyses, it was not realized any relation among the SPT-T parameters and the pedology or topography, inside the urban zone of the Cambezinho creek basin. However, it was realized that the spacial behavior of the relation between the resistance parameters measured in the SPT-T ,NSPT and Maximum Torque, is the same as observed in the analyses of isolated tests field, which means that they are approximately equal, and as the bigger is the intemperization level that the soil has suffered the smaller is the resistance it reaches.
Pozo, Romero Jaime Augusto del. « Plan de Negocios : Livian : “Yogurt Probiótico Natural con Frutas para el NSE “B” de Lima Metropolitana" ». Tesis, Universidad de Chile, 2010. http://www.repositorio.uchile.cl/handle/2250/102278.
Texte intégralWiener, Carolina David. « Níveis séricos de ácido úrico e as atividades a superóxido dismutase e da catalase nos transtornos de humor ». Universidade Catolica de Pelotas, 2013. http://tede.ucpel.edu.br:8080/jspui/handle/tede/517.
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Objectives: The aim of this study was evaluate uric acid level in a population–based sample of young adults (18 to 24 years old). People with bipolar and depression disorder were compared with healthy psychiatric subjects without a history of mood episodes. Methods: Case-control study nested in a population-based sample. The diagnosis was confirmed with the Structured Clinical Interview for DSM-IV. The uric acid was assessed by commercial kits Results: The sample consisted of 216 subjects, 49 with diagnosis for bipolar disorder, 76 with depression and 91 population control. The uric acid levels were similar (control = 4.08 ± 1.27 mg/dL, depression = 3.78 ± 1.00 mg/dL e bipolar disorder =3.86 ± 1.33 mg/dL, p= 0,251). For maniac/hippomaniac and depressive episodes, were observed a tendency to increase in acid uric levels in maniac/hippomaniac episodes (4.43 ± 1.74 mg/dL) and a decrease in depressive episodes (3.70 ± 0.99 mg/dL) when compared to control subjects (4.08 ± 1.27 mg/dL)(p= 0.106). Conclusion: Uric acid levels is not correlated with diagnosis group, but the uric acid level have a tendency to presented increased in manic and/ or mixed episodes and decreased in depression episode, these result observed that levels of uric acid in mood disorders are altered according to the manifestation of symptoms.
Objetivo: O objetivo deste estudo é avaliar o nível de acido úrico em pacientes com transtornos de humor oriundo de uma amostra de base populacional com jovens adultos (18 a 24 anos), para este fim jovens com transtorno de humor bipolar e depressão foram comparados com jovens sem histórico de transtorno de humor. Métodos: Trata-se de um estudo de caso-controle aninhado a um estudo de base populacional, o diagnostico foi realizado através da Entrevista Clínica Estruturada para o DSM-IV (SCID) e os níveis de acido úrico séricos foram dosados utilizando-se kits comerciais. Resultados: A amostra foi constituída de 216 jovens, 49 com diagnostico de transtorno bipolar, 76 com depressão e 91 controles sem historia psiquiátrica prévia, os níveis de acido úrico entre os três grupos foram similares (controle = 4.08 ± 1.27 mg/dL, depressão = 3.78 ± 1.00 mg/dL e transtorno bipolar =3.86 ± 1.33 mg/dL, p= 0,251). Quando avaliados os níveis de ácido úrico entre os episódios mania/hipomania e depressivo, observa-se uma tendência no aumento do ácido úrico no episódio maníaco/misto (4,43 ± 1,74 mg/dL) e uma diminuição no episódio depressivo (3,70 ± 0,99 mg/dL) quando comparados aos jovens do grupo controle (4,08 ± 1,27 mg/dL)(p= 0,106). Conclusão: Os níveis de ácido úrico não foram significativos entre os grupos diagnósticos, porém os níveis de acido úrico apresentaram uma tendência para o aumento nos episódios maníacos e/ou mistos e uma diminuição no episódio depressivo, com estes resultados podemos observar que os níveis de acido úrico nos transtornos de humor podem estar alterados de acordo com a manifestação dos sintomas