Thèses sur le sujet « Novel glycolipids »
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Röthlisberger, Peter. « Lipoteichoic acid and glycolipids of a novel streptococcus / ». [S.l.] : [s.n.], 1995. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=11149.
Texte intégralZeb, Neelofar. « Synthesis and lyotropic phase behaviour of novel glycolipids ». Thesis, Imperial College London, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.336634.
Texte intégralWonjo, Justyna. « Novel glycolipids in CD1d-mediated immunity : synthesis of new agonists of CD1d ». Thesis, University of Birmingham, 2012. http://etheses.bham.ac.uk//id/eprint/3551/.
Texte intégralCes, Oscar. « The phase behaviour of glycolipids employing a novel high-pressure X-ray beamline ». Thesis, Imperial College London, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.416049.
Texte intégralPIAZZA, MATTEO. « Synthesis and biological characterization of novel TLR4 ligands ». Doctoral thesis, Università degli Studi di Milano-Bicocca, 2009. http://hdl.handle.net/10281/7784.
Texte intégralChaudhary, Vinod. « Isolation, Characterization and Synthesis of Asthma Inducing Fungal Glycolipid and Analytical Method Development for Novel Antimicrobial Peptide Mimics ». BYU ScholarsArchive, 2013. https://scholarsarchive.byu.edu/etd/4039.
Texte intégralPöhnlein, Martin Stefan [Verfasser], et C. [Akademischer Betreuer] Syldatk. « Investigations on the Enzymatic Synthesis of Novel Glycolipids - Establishment and optimization of the synthesis including product characterization / Martin Stefan Pöhnlein. Betreuer : C. Syldatk ». Karlsruhe : KIT-Bibliothek, 2014. http://d-nb.info/1059803100/34.
Texte intégralGarcia, Diaz Yoel R. « Synthesis of Novel Glycolipid Agonists of the Protein CD1d ». Thesis, University of Birmingham, 2010. http://etheses.bham.ac.uk//id/eprint/544/.
Texte intégralFarr, Dylan C. « Design and Synthesis of Novel Glycolipid Therapeutics and Drug Delivery Systems Targeting Mycobacterium tuberculosis ». Thesis, Griffith University, 2021. http://hdl.handle.net/10072/406985.
Texte intégralThesis (PhD Doctorate)
Doctor of Philosophy (PhD)
Institute for Glycomics
Griffith Health
Full Text
Baba, Teruhiko. « Studies on Physicochemical Properties of Novel Phytanyl-Chained Glycolipid Bilayer Membranes and Their Biotechnological Application ». 京都大学 (Kyoto University), 2001. http://hdl.handle.net/2433/150430.
Texte intégralKriat, Mostafa. « Etude des liquides biologiques par spectroscopie de résonance magnétique nucléaire : développement d'un nouvel outil de biologie clinique ». Aix-Marseille 1, 1992. http://www.theses.fr/1992AIX11002.
Texte intégralPalmer, Charys. « Modulation of TLR4 Signalling by Novel Synthetic Glycolipids ». Thesis, 2021. https://arro.anglia.ac.uk/id/eprint/707210/1/Palmer_2021.pdf.
Texte intégralLin, Chia-Ming, et 林家銘. « Structural determination of glycolipids extracted from novel thermophilic, radiation resistant, indigenous strain, NTU-1233 ». Thesis, 2008. http://ndltd.ncl.edu.tw/handle/61861535758653075542.
Texte intégral國立臺灣大學
生化科學研究所
96
According to previous studies, glycolipids are the major components present in the cell surface of thermophilic bacteria. The high proportion of glycolipids in the cell membranes could possibly to contribute to the ability of the bacteria to grow at high temperature, however, the molecular basis of this phenomenon is still unclear. The structure of glycolipid of thermophilic bacteria has long been a topic and has been proved to exhibit great structural diversity due to its high temperature growth condition. This study focuses on the structural analyses of glycolipids isolated from this new indigenous of Taiwan, NTU-1233. Lipid crude extracts from two type strains, Truepera radiovitrix and Deinococcus murrayi; and five indigenous strains, NTU-484, NTU-1233, NTU-1085, NTU-1089, NTU-407 were subjected to TNF-α induction assay and found that lipid crude extracts of NTU-1233 exhibits stronger immunostimulation activity. The structures of three major glycolipids purified from lipid crude extracts of NTU-1233 were determined using TLC, NMR spectroscopy (TOCSY, COSY, HSQC, HMBC), GC-MS, MALDI-MS and ESI-MS, and chemical analyses. According to the spectroscopic and chemical analyses, the structures of three glycolipids are elucidated to be two sulfolipids sulfoquinovosyl diacylglycerol [SQDG] and its acylated derivative, 2’-O-acyl-sulfoquinovosyl diacylglycerol [ASQD], and a novel sphingolipid, glucosaminyl(1-3)-β-galactosyl-(1-1’)-dihydroceramide [GlcNAcα3Galβ- Cer]. The acyl chain of fatty acid moiety of these three glycolipids are saturated according NMR analysis. It is the first time for ASQD to be found in nonphotosynthetic organism, and for GlcNAcα3GalβCer, it is a novel compound that has never been reported before.
Lin, Chia-Ming. « Structural determination of glycolipids extracted from novel thermophilic, radiation resistant, indigenous strain, NTU-1233 ». 2008. http://www.cetd.com.tw/ec/thesisdetail.aspx?etdun=U0001-2601200823233100.
Texte intégralChiu, Shih-Wen, et 邱世文. « Structural Characterization and Immunoactivity of Glycolipids from a Novel Indigenous Radiation-Resistant Thermophilic Bacterium, NTU-806 ». Thesis, 2009. http://ndltd.ncl.edu.tw/handle/t25xjk.
Texte intégral國立臺北科技大學
生物科技研究所
97
Glycolipids exhibit great structural diversity and play important roles in biology system. Previous studies indicated that the structures of glycolipids were the major components of thermophilic bacteria cell membrane. Here, we aim to discover the novel glycolipids which have bioactivity of immunomodulation from radiation-resistant thermophilic bacteria found in Taiwan. Our study focus on the immunoactivity and structural analyses of Genus Rubrobacter glycolipids isolated from hot springs indigenous to Taiwan. The glycolipid crude extracts from strains NTU-520, NTU-806, NTU-808, NTU-829, NTU-1102, NTU-1106, NTU-1110, NTU-1119 and NTU-1129 of Genus Rubrobacter were subjected to TNF-α induction assay. Result shows glycolipid crude extracts of NTU-806 possesses highest immunostimulation activity. Structure composition analysis of NTU-806 by Column Chromatography, and were determined NMR spectroscopy, Mass spectrometer, indicated this strain contain two major sulfolipids; (6-(2-butyramido- 3-hydroxyheptyloxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)methanesulfonate (SQC) and (6-(2-(butyryloxy)-3-propoxypropoxy)-3,4,5-trihydroxytetrahydro-2H- pyran-2-yl) methanesulfonate (SQMG). It is the very first time for SQC to be found in linkage between sulfoquinovose and ceramide which is a novel compound that has never been reported before.
Guru, Raja V. « Novel Redox Responsive Cationic Lipids, Lipopolymers, Glycolipids And Phospholipid-Cationic Lipid Mixtures : Syntheses, Aggregation And Gene Transfection Properties ». Thesis, 2014. http://etd.iisc.ernet.in/handle/2005/2979.
Texte intégralHa, Stephanie A. « A Novel Periplasmic Protein involved in the Mannan Chain Elongation Step of Lipomannan and Lipoarabinomannan Biosynthesis in Mycobacterium smegmatis ». 2017. https://scholarworks.umass.edu/masters_theses_2/466.
Texte intégralKamani, Mustafa. « Novel Intrinsic and Extrinsic Approaches to Selectively Regulate Glycosphingolipid Metabolism ». Thesis, 2013. http://hdl.handle.net/1807/35860.
Texte intégralHuang, Yen-Lin, et 黃彥霖. « Development of Globo H anti-breast cancer vaccines with novel glycolipid adjuvants ». Thesis, 2008. http://ndltd.ncl.edu.tw/handle/75879194308270055791.
Texte intégral國立臺灣大學
生化科學研究所
96
Aberrant glycosylation is often a hallmark during tumor progression and correlates with poor prognosis. Diverse tumor associated antigens existed in the form of glycolipids or glycoproteins have been characterized. Globo H (Fucα1→2Galβ1→3 GalNAcβ1→3Galα1→4Galβ1→4Glu) hexasaccharide was first isolated from metastatic breast cancer cells by Hakomori in 1984 and initially synthesized by Danishefsky using glycal assembly strategy in 1995. Globo H was present on most cancers of epithelial origin, but only minimal expression on normal secretory tissue which is not readily accessible to immune system. Taking advantage of the exclusive expression signature, Globo H has been an attractive target for immunotherapy against prostate, breast, colon and ovarian cancers. Although, numerous vaccines are undergoing clinical evaluation and some shows improved survival rate in patients, the ultimate goal is to prevent the tumor recurrence. Therefore, we aim to develop a more effective vaccine and adjuvant against a variety of cancers. Here we reported the promising carbohydrate based vaccine enhanced antibody production and delayed tumorigenesis in xenograft studies. Overall, systematic optimization with respect to formulation, adjuvant, dosage, glycan/protein ratio and timing of immunization regimen may further improve the protection against tumors. Finally, conjugation of diverse carbohydrate antigens to various carriers or dendrimer will be planned in the near further.
Huang, Yen-Lin. « Development of Globo H anti-breast cancer vaccines with novel glycolipid adjuvants ». 2008. http://www.cetd.com.tw/ec/thesisdetail.aspx?etdun=U0001-1607200813271400.
Texte intégralShen, Jingkai. « Isolation and structure determination of a novel glycolipid pachymoside A from marine sponge Pachymatisma johnstonia ». Thesis, 2003. http://hdl.handle.net/2429/14604.
Texte intégralRobinson, Nirmal [Verfasser]. « Identification of a novel mycobacterial gene involved in the synthesis of a phenolic glycolipid and its role in the prevention of phagosome maturation / Nirmal Robinson ». 2007. http://d-nb.info/991158849/34.
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