Thèses sur le sujet « Novel drug delivery system »
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Blackwell, Lisa Jane. « Sporopollenin exines as a novel drug delivery system ». Thesis, University of Hull, 2007. http://hydra.hull.ac.uk/resources/hull:7162.
Texte intégralSalvage, Jonathan Peter. « A novel phosphorylcholine-based nanoparticulate drug delivery system ». Thesis, University of Brighton, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.499068.
Texte intégralMODICA, DE MOHAC Laura. « Novel Drug Delivery System for Treatment-Resistant Schizophrenia ». Doctoral thesis, Università degli Studi di Palermo, 2021. http://hdl.handle.net/10447/478483.
Texte intégralCampbell, K. C. « Novel systems for transdermal drug delivery ». Thesis, Queen's University Belfast, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.368758.
Texte intégralMawad, Damia Graduate School of Biomedical Engineering Faculty of Engineering UNSW. « Development of Novel hydrogels for protein drug delivery ». Awarded by:University of New South Wales. Graduate School of Biomedical Engineering, 2005. http://handle.unsw.edu.au/1959.4/25221.
Texte intégralBabu, Kavitha Mary Vadakkel. « The Development of a Novel Controlled Release Drug Delivery System ». The University of Waikato, 2007. http://hdl.handle.net/10289/2590.
Texte intégralSy, Jay Christopher. « Novel strategies for cardiac drug delivery ». Diss., Georgia Institute of Technology, 2011. http://hdl.handle.net/1853/39531.
Texte intégralVenugopal, Balaji. « Preclinical evaluation of a novel drug delivery system for cisplatin ». Thesis, University of Glasgow, 2012. http://theses.gla.ac.uk/4198/.
Texte intégralSvirskis, Darren. « Development of a novel drug delivery system based on conducting polymers ». Thesis, University of Auckland, 2010. http://hdl.handle.net/2292/6568.
Texte intégralGaspar, Diana Patrícia Rodrigues. « Novel strategy to produce a drug delivery system for skin regeneration ». Master's thesis, Universidade da Beira Interior, 2012. http://hdl.handle.net/10400.6/1118.
Texte intégralAs lesões na pele são acontecimentos traumáticos que levam ao aumento da perda de fluidos, a infecções, à formação de cicatrizes e ao aparecimento de regiões imunocomprometidas. Estas feridas podem ser causadas por desordens de origem genética, traumas ou mesmo devido a cirurgias. Deste modo, uma área substancial da pele pode ser danificada, muitas vezes sem a possibilidade de regeneração. Os investigadores têm procurado desenvolver novos sistemas de entrega de drogas, de forma a acelerar o processo de cicatrização. O microencapsulamento celular surgiu recentemente como uma nova abordagem, para entrega controlada e de longa duração de agentes terapêuticos produzidos e secretados pelas próprias células, tais como componentes da matriz extracelular e factores de crescimento, os quais são essenciais para a regeneração. Esta tecnologia tem por base a imobilização de células, dentro de uma matriz polimérica rodeada por uma membrana semi-permeável. Assim, as células não são reconhecidas pelo sistema imunitário do hospedeiro e a membrana permite a difusão de nutrientes e gases para o interior da matriz e a saída das moléculas bioactivas secretadas pelas células e dos resíduos resultantes do metabolismo celular. No entanto, a terapia celular necessita ainda de ser optimizada. O alginato é um polímero que tem sido usado para o encapsulamento celular, devido ao seu fácil processo de gelificação, excelente biocompatibilidade, biodegradabilidade e estabilidade in vivo. Por outro lado, os sistemas nanoparticulados têm sido amplamente utilizados em aplicações biomédicas, por exemplo na produção de dispositivos de entrega direcionada de moléculas bioactivas, uma vez que permitem obter um perfil de libertação controlado. O presente trabalho teve como objectivo o desenvolvimento de micropartículas de alginato para encapsular fibroblastos humanos e nanopartículas de quitosano, com o intuito de futuramente serem usadas como agentes promotores da cicatrização de feridas. Inicialmente, foram produzidos dois tipos de micropartículas, um à base de alginato e outro de alginato com colagénio. As micropartículas produzidas foram caracterizadas quanto ao seu tamanho e geometria por microscopia electrónica de varrimento. Posteriormente, foram também adquiridas imagens de confocal para confirmar o encapsulamento de células nas micropartículas. O perfil citotóxico dos transportadores foi caracterizado através de testes de viabilidade celular, os quais confirmaram a biocompatibilidade dos transportadores. O perfil de libertação das células foi observado por análise microscópica ao longo dos dias. Numa segunda parte do trabalho foram produzidas nanopartículas de quitosano com o objetivo de serem incorporadas nas micropartículas como transportadores de factores de crescimento e, assim, favorecer a cicatrização das feridas. A eficiência de encapsulação das nanopartículas foi avaliada através da incorporação de uma proteína modelo, albumina de soro bovino. Posteriormente fez-se a caracterização da morfologia e do tamanho destas nanopartículas. Os estudos efectuados demonstraram que o sistema desenvolvido é adequado para a libertação de células e moléculas bioativas de forma controlada, prolongada e em concentrações fisiológicas.
Lungare, Shital. « Development of novel delivery systems for nose-to-brain drug delivery ». Thesis, Aston University, 2017. http://publications.aston.ac.uk/37491/.
Texte intégralBostanian, Levon Artine. « Novel drug delivery systems for relatively insoluble substances / ». The Ohio State University, 1995. http://rave.ohiolink.edu/etdc/view?acc_num=osu14878617968179.
Texte intégralLucato, Arianna <1991>. « Computational design of novel protein-drug delivery systems ». Master's Degree Thesis, Università Ca' Foscari Venezia, 2019. http://hdl.handle.net/10579/16136.
Texte intégralEspeleta, Gonzalez David <1995>. « DEVELOPMENT OF NOVEL PROTEIN-BASED DRUG DELIVERY SYSTEMS ». Master's Degree Thesis, Università Ca' Foscari Venezia, 2021. http://hdl.handle.net/10579/19858.
Texte intégralLee, Wang Wang. « Factors affecting drug release and absorption from a novel oral delayed release drug delivery system ». Thesis, Durham University, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.269886.
Texte intégralGerrard, Stephen Edmund. « A novel infant therapeutic delivery system for drugs, nutrients and anti-viral agents ». Thesis, University of Cambridge, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.648462.
Texte intégralChallis, Deborah. « Physicochemical and biopharmaceutical studies of novel self-emulsifying systems for administration by the oral route (SEDDS) ». Thesis, University of Bath, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.280871.
Texte intégralO'Hear, Carol E. « Antibody buffering : a novel mechanism of drug delivery / ». Thesis, Connect to this title online ; UW restricted, 2004. http://hdl.handle.net/1773/5024.
Texte intégralZhang, Feng. « Hot-melt extrusion as a novel technology to prepare sustained-release dosage forms / ». Digital version accessible at:, 1999. http://wwwlib.umi.com/cr/utexas/main.
Texte intégralTurner, Jonathan D. « Development of a novel in vitro system for nasal drug delivery development ». Thesis, Aston University, 2000. http://publications.aston.ac.uk/10987/.
Texte intégralDonnelly, L. « Synthesis and characterisation of novel polymeric drug delivery systems ». Thesis, Queen's University Belfast, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.398150.
Texte intégralLiu, Yang. « Development of Novel Drug Delivery Systems for Cancer Therapy ». The Ohio State University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=osu153105342400785.
Texte intégralPhan, Tu-Ai Thi. « Novel host-guest systems for ultrasound-mediated drug delivery / ». Available to subscribers only, 2007. http://proquest.umi.com/pqdweb?did=1459908051&sid=2&Fmt=2&clientId=1509&RQT=309&VName=PQD.
Texte intégralBasu, Sarkar Arindam Kochak Gregory Michael. « Carbohydrate nanoparticles a novel drug delivery platform for the systemic route / ». Auburn, Ala., 2006. http://repo.lib.auburn.edu/2006%20Summer/Dissertations/BASU_SARKAR_26.pdf.
Texte intégralMisirlis, Dimitrios. « Development of a novel drug delivery system based on polymeric, thermoresponsive, hydrogel nanoparticles / ». [S.l.] : [s.n.], 2005. http://library.epfl.ch/theses/?nr=3362.
Texte intégralFisher, Karen Ann. « Development of a novel drug delivery system using macrophages and inorganic porous materials ». Thesis, De Montfort University, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.434031.
Texte intégralCarradori, Dario. « Novel nanoparticle-based drug delivery system for neural stem cell targeting and differentiation ». Thesis, Angers, 2017. http://www.theses.fr/2017ANGE0056/document.
Texte intégralNeural stem cells (NSCs) are located in specific regions of the central nervous system called niches. Those cells are able to self-renew and to differentiate into specialized neuronal cells (neurons, astrocytes and oligodendrocytes). Due to this differentiation property, NSCs are studied to replace neuronal cells and restore neurological functions in patients affected by neurodegenerative diseases. Several therapeutic approaches have been developed and endogenous NSC stimulation is one of the most promising. Currently, there is no active molecule or therapeutic system targeting endogenous CSNs and inducing their differentiation at the same time. The aim of the work was to provide a drug delivery system able both to target endogenous CSNs and to induce their differentiation in situ. Here, we developed and characterized lipidic nanoparticles (LNC) targeting endogenous NSCs. A peptide called NFL-TBS.40-63, known for its affinity towards NSCs, was adsorbed at the surface of LNC. We observed that NFL-LNC specifically targeted NSC from the brain and not from the spinal cord in vitro and in vivo. To explain this specificity, we characterized and compared NFL-LNC interactions with the plasmatic membrane of both cell types. Finally, we demonstrated that by loading retinoic acid in NFL-LNC we were able to induce brain NSC differentiation in vitro and in vivo. This work contributes to the development of efficient and safe therapies for the treatment of neurodegenerative disease via the differentiation of endogenous NSCs
Gevorgyan, S. « NOVEL POLY(AMIDOAMINE) NANOPARTICLES DESIGNED FOR DRUG DELIVERY TO THE CENTRAL NERVOUS SYSTEM ». Doctoral thesis, Università degli Studi di Milano, 2016. http://hdl.handle.net/2434/366799.
Texte intégralRizi, Khalida. « Novel Bio-Responsive Drug Delivery Systems to Treat Atopic Dermatitis ». Thesis, University of Reading, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.533776.
Texte intégralKolhe, U. D. « Synthesis and evaluation of polymers for novel drug delivery systems ». Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 2011. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/3825.
Texte intégralMukhopadhyay, Debashis, et n/a. « Preparation and evaluation of novel drug alginate granule systems using paracetamol as model drug ». University of Otago. School of Pharmacy, 2006. http://adt.otago.ac.nz./public/adt-NZDU20070503.143431.
Texte intégralPavuluri, Nina. « Development and evaluation of drug-admicelle systems for poorly soluble drugs : a novel surfactant templated drug delivery platform / ». Full text available from ProQuest UM Digital Dissertations, 2008. http://0-proquest.umi.com.umiss.lib.olemiss.edu/pqdweb?index=0&did=1781035201&SrchMode=1&sid=1&Fmt=2&VInst=PROD&VType=PQD&RQT=309&VName=PQD&TS=1258661510&clientId=22256.
Texte intégralTypescript. Vita. Major advisor: John O' Haver "June 2008." Includes bibliographical references (leaves 120-163). Also available online via ProQuest to authorized users.
Fransén, Nelly. « Studies on a novel powder formulation for nasal drug delivery / ». Uppsala : Acta Universitatis Upsaliensis Acta Universitatis Upsaliensis, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-9292.
Texte intégralCheung, Wai-Han. « Novel steroidal metal complexes with potential pharmaceutical applications ». Thesis, Loughborough University, 1992. https://dspace.lboro.ac.uk/2134/27879.
Texte intégralColby, Aaron Henry. « Novel drug delivery systems : pH-responsive expansile nanoparticles & ; drug concentrating devices as tools for treating cancer ». Thesis, Boston University, 2008. https://hdl.handle.net/2144/30651.
Texte intégralNew strategies for treatment and methods of drug delivery are required for patients suffering from cancer-the second leading cause of death worldwide. Current chemotherapeutic treatments frequently suffer from poor water solubility, systemic toxicity, poor accumulation within the target tissues and an inability to eradicate all remaining tumor following resection procedures. Nanoparticles (NPs) are extensively investigated as a means to increase drug solubility, alter biodistribution, target specific sites within the body, and minimize drug side effects and, as such, numerous NP formulations are being investigated as drug delivery devices to assist in the treatment and management of cancer. We have developed a pH-responsive expansile nanoparticle (eNP) that can encapsulate the hydrophobic chemotherapeutic agent Paclitaxel (Pax) (a poorly water soluble, yet potent chemotherapeutic agent), and deliver it specifically to the intracellular compartment of tumor cells. Paclitaxel-loaded-eNPs (Pax-eNPs) localize specifically to regions of intraperitoneal (IP) tumors and, once taken up by tumor cells, undergo a conformational change upon exposure to the mildly acidic cellular endosome that results in eNP swelling and intratumoral drug release. In this work, we describe: 1) the clinical problem and cost (both humanitarian and fmancial) of local cancer recurrence following tumor resection; 2) the eNP delivery system and, specifically, we characterize the swelling of eNPs using microscopy and tunable resistive pulse sensing techniques; 3) the in vitro activity of Pax-eNPs in breast cancer cells; 4) the improved efficacy of Pax- eNPs compared to the standard clinical formulation of Pax (i.e., Pax dissolved in Cremophor/Ethanol) in a murine model of established peritoneal mesothelioma; and, 5) the ability of eNPs to act as intratumoral, intracellular drug concentrating devices. Further investigation of this NP-based drug delivery system will facilitate a greater understanding of the materials and devices used in the delivery of chemotherapeutic agents and may lead to the clinical translation and application of eNPs.
2019-05-01
Wang, Han. « Developing Novel Drug Delivery Systems For Platinum-based Anticancer Drugs Using Coordination-driven Self-assembly ». Kent State University / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=kent1595260147978142.
Texte intégralRattanakiat, Sakulrat. « Development of novel DNA-based nanosized drug delivery system using DNA containing unmethylated CpG dinucleotides ». 京都大学 (Kyoto University), 2009. http://hdl.handle.net/2433/126606.
Texte intégralMcBride, Eileen. « The development of a novel drug delivery system for the treatment of inflammatory bowel disease ». Thesis, University of Strathclyde, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.501659.
Texte intégralLiu, Quan. « Development of a novel gastro-retentive delivery system using alfuzosin HCl as a model drug ». Diss., Temple University Libraries, 2010. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/80170.
Texte intégralPh.D.
The objectives of this project encompass the design and development of a drug delivery system to continuously deliver therapeutic agents from the stomach to the proximal region of the intestine. The delivery system designed would have sufficient gastric residence time together with near zero-order release kinetics. The physicochemical properties pertaining to the formulation development of the model drug (alfuzosin HCl) were evaluated. Excipients were selected based on the studies of their physicochemical properties and compatibility with the active ingredient. Gastro-retentive dosage forms have been the topic of interest in recent years as a practical approach in drug deliveries to the upper GI tract or for release prolongation and absorption. These dosage forms are particularly suitable for drugs that have local effects on the gastric mucosa in the stomach. Other candidates include drugs that are likely to be absorbed in the upper small intestine, or drugs that are unstable in basic environment of distal intestine and colon or those with low solubility at elevated pH conditions (i.e. weak bases). To develop a gastro-retentive delivery system the following steps were taken. First, to investigate the possible incompatibility issues between the model drug and excipients to be used for the delivery system. Stability and physicochemical properties of the active agent and its mixture with excipients were studied using analytical techniques such as Raman spectroscopy and Differential scanning calorimetry (DSC). No incompatibility issues were detected. Second, Kollidon SR as a relatively new release-rate controlling polymer was incorporated in the final formulation. For solid dosage form the ability of the final powder mix to flow well during manufacturing and the intrinsic characteristics that make it compressible are critical. The in-depth compaction study of Kollidon SR was assessed with the help of a compaction simulator. The flowability, swelling and erosion behavior together with release-rate retarding properties of Kollidon SR were also assessed. The final oral delivery system was based on Kollidon SR and Polyethylene Oxide (PEO) 303 as a monolithic matrix system. The noneffervescent monolithic matrix was made by direct compression. In vitro evaluation of the designed system released the active content in a near zero manner. The dosage form was bouyant in pH 2.0 acidic buffer with no floatation lag time which minimizes the possibility of early gastric emptying.
More, N. A. « Design synthesis and biological evaluation of novel heterocycles and their encapsulation in drug delivery system ». Thesis(Ph.D.), CSIR-National Chemical Laboratory, 2020. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/5902.
Texte intégralHelfrich, Marcus Robert. « Preliminary investigations into the development of novel layered phosphonic acid vesicles for targeted drug delivery applications / ». view abstract or download file of text, 2002. http://wwwlib.umi.com/cr/uoregon/fullcit?p3045088.
Texte intégralTypescript. Includes vita and abstract. Includes bibliographical references (leaves 184-193). Also available for download via the World Wide Web; free to University of Oregon users. Address: http://wwwlib.umi.com/cr/uoregon/fullcit?p3045088.
Farr, Dylan C. « Design and Synthesis of Novel Glycolipid Therapeutics and Drug Delivery Systems Targeting Mycobacterium tuberculosis ». Thesis, Griffith University, 2021. http://hdl.handle.net/10072/406985.
Texte intégralThesis (PhD Doctorate)
Doctor of Philosophy (PhD)
Institute for Glycomics
Griffith Health
Full Text
Johnston, Alexander Henderson. « Novel approaches to dendrimer based radiopharmaceutical imaging agents and drug delivery systems ». Thesis, University of Southampton, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.582662.
Texte intégralMURA, CARLA. « Preparation, development and evaluation of novel drug delivery systems for colon targeting ». Doctoral thesis, Università degli Studi di Cagliari, 2011. http://hdl.handle.net/11584/266294.
Texte intégralNahak, Prasant. « Physicochemical studies on lipidic components with special reference to monolayer, bilayer,and solid lipid nanoparticle ». Thesis, University of North Bengal, 2017. http://ir.nbu.ac.in/handle/123456789/3967.
Texte intégralGunji, Shutaro. « A novel drug delivery system of intraperitoneal chemotherapy for peritoneal carcinomatosis using gelatin microspheres incorporating cisplatin ». Kyoto University, 2013. http://hdl.handle.net/2433/180608.
Texte intégralEsfand, Roseita. « Synthesis and characterisation of dendrimer-drug complexes and evaluation of dendrimeric compounds as novel drug delivery systems ». Thesis, University of Kent, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.241934.
Texte intégralColby, Aaron Henry. « Novel drug delivery systems : pH-responsive expansile nanoparticles & ; drug concentrating devices as tools for treating cancer ». Thesis, Boston University, 2014. https://hdl.handle.net/2144/12957.
Texte intégralNew strategies for treatment and methods of drug delivery are required for patients suffering from cancer-the second leading cause of death worldwide. Current chemotherapeutic treatments frequently suffer from poor water solubility, systemic toxicity, poor accumulation within the target tissues and an inability to eradicate all remaining tumor following resection procedures. Nanoparticles (NPs) are extensively investigated as a means to increase drug solubility, alter biodistribution, target specific sites within the body, and minimize drug side effects and, as such, numerous NP formulations are being investigated as drug delivery devices to assist in the treatment and management of cancer. We have developed a pH-responsive expansile nanoparticle (eNP) that can encapsulate the hydrophobic chemotherapeutic agent Paclitaxel (Pax) (a poorly water soluble, yet potent chemotherapeutic agent), and deliver it specifically to the intracellular compartment of tumor cells. Paclitaxel-loaded-eNPs (Pax-eNPs) localize specifically to regions of intraperitoneal (IP) tumors and, once taken up by tumor cells, undergo a conformational change upon exposure to the mildly acidic cellular endosome that results in eNP swelling and intratumoral drug release. In this work, we describe: 1) the clinical problem and cost (both humanitarian and fmancial) of local cancer recurrence following tumor resection; 2) the eNP delivery system and, specifically, we characterize the swelling of eNPs using microscopy and tunable resistive pulse sensing techniques; 3) the in vitro activity of Pax-eNPs in breast cancer cells; 4) the improved efficacy of Pax- eNPs compared to the standard clinical formulation of Pax (i.e., Pax dissolved in Cremophor/Ethanol) in a murine model of established peritoneal mesothelioma; and, 5) the ability of eNPs to act as intratumoral, intracellular drug concentrating devices. Further investigation of this NP-based drug delivery system will facilitate a greater understanding of the materials and devices used in the delivery of chemotherapeutic agents and may lead to the clinical translation and application of eNPs.
Scally, David James. « Novel polyethylene glycol based drug delivery systems : a calorimetric and QASAR based study ». Thesis, University of Kent, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.282425.
Texte intégralWehrung, Daniel. « Development and Evaluation of Novel Light-Responsive Drug Delivery Systems from Alkoxyphenacyl Polycarbonates ». NEOMED Integrated Pharmaceutical Medicine / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=ne2mh1441828458.
Texte intégral