Articles de revues sur le sujet « NIDA 1.0 »

1.Curso de Extensión Universitaria “Traducción e interculturalidad en la época contemporánea”, segunda edición.Organiza: CRET-Grupo de Investigación Consolidado sobre Traducción y Multiculturalidad (UB)Universidad de Barcelona (Facultad de Filología), del 18 de octubre al 24 de noviembre de 2010. Curso internacional de 30h., con 3 créditos de libre elección reconocidos. Inscripción: Secretaría de la Facultad de Filología, Gran Vía de las Cortes Catalanas, 585, Barcelona. Información y preinscripciones: cret@ub.edu. Plazas limitadas.2.Congreso Internacional: II Congreso Internacional sobre Traducción e Interculturalidad / XIII Congreso de la Sociedad Española de Italianistas (SEI): “La traducción en las relaciones ítalo-españolas: lengua, literatura, cultura”, Universidad de Barcelona (Facultad de Filología), del 16 al 19 de noviembre de 2010.Organiza: CRET-Grupo de Investigación Consolidado sobre Traducción y Multiculturalidad (UB), en colaboración con la “Sociedad Española de Italianistas” (SEI).Inscripción: cret@ub.eduPara más información: http://www.ub.edu/lettere/congrés_20103.Nuevo libro: Translation and the Machine: Technology, Meaning, Praxis. Steve Berneking & Scott S. Elliott (eds.), Nida Institute Conference Papers 2 (Rome: Edizioni di Storia e Letteratura, 2009). ISBN: 978-88-8498-468-5; ABS Item Number: 120710; Retail Price: $45,00. Ordering Information: USA: www.Bibles.com or 1-800-32-BIBLE Canada: www.biblesociety.ca or 800-564-2425 Italy: info@storiaeletteratura.it or (0039) 063 967 0307 All other countries: www.casalini.it or (0039) 055 501 8201 Contact information: Charles Houser, Editorial & Publications Manager Nida Institute for Biblical Scholarship American Bible Society, 1865 Broadway, New York, NY 10023 Phone (212) 408-1235 / Fax (212) 408-1435 / Email chouser@americanbible.org4.Nuevo libro: Alexander C.Y. Huang. Chinese Shakespeares: Two Centuries of Cultural Exchange. New York: Columbia UP, 2009. ISBN: 978-0-231-14849-8. US$ 23,85. <http://cup.columbia.edu/book/978-0-231-14848-1/chinese-shakespeares>

1.Curso de Extensión Universitaria “Traducción e interculturalidad en la época contemporánea”, segunda edición.Organiza: CRET-Grupo de Investigación Consolidado sobre Traducción y Multiculturalidad (UB)Universidad de Barcelona (Facultad de Filología), del 18 de octubre al 24 de noviembre de 2010. Curso internacional de 30h., con 3 créditos de libre elección reconocidos. Inscripción: Secretaría de la Facultad de Filología, Gran Vía de las Cortes Catalanas, 585, Barcelona. Información y preinscripciones: cret@ub.edu. Plazas limitadas.2.Congreso Internacional: II Congreso Internacional sobre Traducción e Interculturalidad - XIII Congreso de la Sociedad Española de Italianistas (SEI): “La traducción en las relaciones ítalo-españolas: lengua, literatura, cultura”, Universidad de Barcelona (Facultad de Filología), del 16 al 19 de noviembre de 2010.Organiza: CRET-Grupo de Investigación Consolidado sobre Traducción y Multiculturalidad (UB), en colaboración con la “Sociedad Española de Italianistas” (SEI).Inscripción: cret@ub.eduPara más información: http://www.ub.edu/lettere/congrés_20103.Congreso Internacional: 23rd CATS Annual Conference, Concordia University, Montreal, May 28-30, 2010: “Research Methodology in Translation and Interpretation Studies” Organizers: Clara Foz, Ryan Fraser (cfoz@uottawa.ca, ryan.fraser@uottawa.ca). A selection of papers presented at the conference will be published. Please consult the CATS website for further details: http://www.uottawa.ca/associations/act-cats4.Nuevo libro: Translation and the Machine: Technology, Meaning, Praxis. Steve Berneking & Scott S. Elliott (eds.), Nida Institute Conference Papers 2 (Rome: Edizioni di Storia e Letteratura, 2009). ISBN: 978-88-8498-468-5; ABS Item Number: 120710; Retail Price: $45.00. Ordering Information: USA: www.Bibles.com or 1-800-32-BIBLE Canada: www.biblesociety.ca or 800-564-2425 Italy: info@storiaeletteratura.it or (0039) 063 967 0307 All other countries: www.casalini.it or (0039) 055 501 8201 Contact information: Charles Houser, Editorial & Publications Manager Nida Institute for Biblical Scholarship American Bible Society, 1865 Broadway, New York, NY 10023 Phone (212) 408-1235 / Fax (212) 408-1435 / Email chouser@americanbible.org5.Nuevo libro: Alexander C.Y. Huang. Chinese Shakespeares: Two Centuries of Cultural Exchange. New York: Columbia UP, 2009. ISBN: 978-0-231-14849-8. US$ 23.85. <http://cup.columbia.edu/book/978-0-231-14848-1/chinese-shakespeares> 6.Curso de verano:Curso de verano de carácter doctoral organizado por CETRA 2010 en su 22ª edición - Katholieke Universiteit Leuven (KUL), Bélgica, 16 - 28 de agosto de 2010. Profesor invitado de esta edición: Sherry Simon ( http://www.kuleuven.be/cetra/people/sherry_simon.html), Concordia University. Para más información: contactar con Reine Meylaerts: reine.meylaerts@arts.kuleuven.be Visite la web de CETRA: http://www.kuleuven.be/cetra/index/e

ABSTRACT Biodegradation of petroleum hydrocarbons in cold environments, including Alpine soils, is a result of indigenous cold-adapted microorganisms able to degrade these contaminants. In the present study, the prevalence of seven genotypes involved in the degradation of n-alkanes (Pseudomonas putida GPo1 alkB; Acinetobacter spp. alkM; Rhodococcus spp. alkB1, and Rhodococcus spp. alkB2), aromatic hydrocarbons (P. putida xylE), and polycyclic aromatic hydrocarbons (P. putida ndoB and Mycobacterium sp. strain PYR-1 nidA) was determined in 12 oil-contaminated (428 to 30,644 mg of total petroleum hydrocarbons [TPH]/kg of soil) and 8 pristine Alpine soils from Tyrol (Austria) by PCR hybridization analyses of total soil community DNA, using oligonucleotide primers and DNA probes specific for each genotype. The soils investigated were also analyzed for various physical, chemical, and microbiological parameters, and statistical correlations between all parameters were determined. Genotypes containing genes from gram-negative bacteria (P. putida alkB, xylE, and ndoB and Acinetobacter alkM) were detected to a significantly higher percentage in the contaminated (50 to 75%) than in the pristine (0 to 12.5%) soils, indicating that these organisms had been enriched in soils following contamination. There was a highly significant positive correlation (P < 0.001) between the level of contamination and the number of genotypes containing genes from P. putida and Acinetobacter sp. but no significant correlation between the TPH content and the number of genotypes containing genes from gram-positive bacteria (Rhodococcus alkB1 and alkB2 and Mycobacterium nidA). These genotypes were detected at a high frequency in both contaminated (41.7 to 75%) and pristine (37.5 to 50%) soils, indicating that they are already present in substantial numbers before a contamination event. No correlation was found between the prevalence of hydrocarbon-degradative genotypes and biological activities (respiration, fluorescein diacetate hydrolysis, lipase activity) or numbers of culturable hydrocarbon-degrading soil microorganisms; there also was no correlation between the numbers of hydrocarbon degraders and the contamination level. The measured biological activities showed significant positive correlation with each other, with the organic matter content, and partially with the TPH content and a significant negative correlation with the soil dry-mass content (P < 0.05 to 0.001).

Abstract Introduction Physicians prescribing hypnotics remain concerned regarding patient’s inability to discontinue hypnotics after chronic use. That concern has never been directly tested in a controlled prospective study using self-administration choice procedures. This is an update on results from an on-going “blinded” clinical trial in which insomnia subjects are instructed to stop taking their study medication after 6 months of nightly use. Methods DSM-V diagnosed insomnia subjects, aged 23-61 yrs, (n=31, 26 females), with disturbed sleep (i.e., polysomnographic sleep efficiency of ≤85%), no other sleep disorder, unstable medical or psychiatric diseases or drug dependency completed the trial. Participants were randomized to zolpidem XR (12.5 mg), eszopiclone (3 mg), or placebo nightly for 6 months (blinded groups A: n=11, B: n=9, C: n=11). After 6 months, nightly use, over a 2-week choice period, they were instructed to discontinue hypnotic use, but if necessary, to self-administer either 1, 2, or 3 capsules of their assigned medication (zolpidem XR 6.25 mg, 6.25 mg, placebo; eszopiclone 2 mg, 1 mg, placebo as capsules 1, 2 and 3 respectively; or 3 placebos). Results The number of capsules taken declined from week 1 to 2 (p&lt; .001). Over the 2 weeks 15 participants took 0 (48%), 12 ≤ 6 (39%) and 4 ≥10 total capsules (1 each took 42, 19, 13, and 10). Among those taking capsules, most took one capsule per night and 6 took &gt; 1 capsule. Those 4 taking ≥ 10 were younger (p&lt;.05), but did not differ in screening sleep efficiency or blinded treatment group. Importantly 1 subject took every capsule available. Conclusion The majority (87%) of the participants discontinued 6-month nightly hypnotic use (i.e. took ≤ 6 total capsules) and among those taking capsules the rate declined from week 1 to 2. Age may help identify the few with difficulty discontinuing. Support NIDA, grant#: R01DA038177 awarded to Dr. Roehrs

1.Curso de Extensión Universitaria “Traducción e interculturalidad en la época contemporánea”Organiza: CRET-Grupo de Investigación Consolidado sobre Traducción y MulticulturalidadUniversidad de Barcelona (Facultad de Filología), del 5 de octubre al 17 de diciembre de 2009. Curso de 20h., con 2 créditos de libre elección reconocidos. Matrícula: Secretaría de la Facultad de Filología, Gran Vía de las Cortes Catalanas, 585, Barcelona. Para más información: cret@ub.edu2.Congreso Internacional: XIII Congreso de la Sociedad Española de Italianistas (SEI): “La traducción en las relaciones ítalo-españolas: lengua, literatura, cultura”, Universidad de Barcelona (Facultad de Filología), del 16 al 19 de noviembre de 2010.Organiza: CRET-Grupo de Investigación Consolidado sobre Traducción y Multiculturalidad, en colaboración con la SEI.Inscripción y envío de propuestas de comunicación: cret@ub.edu , hasta el 30 de noviembre de 2009.Para más información, cret@ub.edu, y ww.ub.edu/lettere/congreso_20103.Congreso Internacional: “The Sociological Turn in Translation and Interpreting Studies” The Fifth Biennial Conference of the American Translation & Interpreting Studies Association (ATISA) April 22-24, 2010, New York University (NYU), New York, NY Send your proposals to the Chair of the ATISA Scientific Committee at claudia.angelelli@sdsu.edu. For more information about the conference, visit the conference registration page. E-mail your questions to translationconf2010@nyu.edu.4.Congreso Internacional: Congress Japan Jan 2010 “Translation Studies in the Japanese Context”, 9-10 January 2010, Ritsumeikan University, Kyoto, Japan http://translationstudies.net/tsc2010/ Organized by Nana Sato-Rossberg, Paul Dumouchel and Kozo Watanabe Ritsumeikan University, Graduate School for Core Ethics and Frontier Sciences. In collaboration with the Global COE Ars Vivendi: Forms of Human Life and Survival. Submission e-mail address (submissions only): TSC2010-Rits@translationstudies.net Further information: TSC2010-Info@Rossberg.net5.Congreso Internacional: “Adapting, Translating, Transforming”. We would welcome contributions that focus on the following issues: * the role of the translator and whether it differs from that of an adapter * the metaphorical meanings of both terms: translation as transformation or transfer, adaptation as psychological adjustment to a particular context. * translation and adaptation as politically loaded terms * the semiotic systems underlying translation and adaptation * 'openness' versus 'restriction' - do translations differ from adaptations in the way they approach either the source or the target text? * social constructions: the translator as mediator between two languages and two cultures; the adapter as mediator between media and cultures; * the role of the imagination and/or the emotions in the act of translation or adaptation * the role of the academy and/or recent scholarship in shaping attitudes towards both disciplines Contributions, in the form of short (150-250 word) proposals, should be sent to the joint editors, Laurence Raw (l_rawjalaurence@yahoo.com) and Joanne Collie (mail@jmacollie.co.uk) by 31 December 2009.6.Congreso Internacional: "Interpreting... Naturally: International Symposium on Interpreting Studies in Honour of the 80th Birthday of Brian Harris", 10th International Conference on Translation, Universitat Jaume I, Castellón, Spain, 12-13 November 2009 Contact details: Please contact María J. Blasco, blascom@trad.uji.es and Amparo Jiménez, jimenez@trad7.Congreso Internacional: 23rd CATS Annual Conference, Concordia University, Montreal, May 28-30, 2010: “Research Methodology in Translation and Interpretation Studies” Organizers: Clara Foz, Ryan Fraser (cfoz@uottawa.ca, ryan.fraser@uottawa.ca). A selection of papers presented at the conference will be published. Please consult the CATS website for further details: http://www.uottawa.ca/associations/act-cats8.Congreso Internacional: "Diasporic Acts of Identity: Dialogic Approaches to Translation and Creolization" for ACLA conference in New Orleans, April 1-4, 2010 * Seminar Organizer: Jorge Jimenez-Bellver, UMass Amherst; Antonia Carcelen-Estrada, UMass Amherst If you wish to submit a proposal, please click on the following link: www.acla.org/submit/index.php. For questions, please contact Jorge Jiménez Bellver at jimenezb@complit.umass.edu.9.Nuevo libro: Translation and the Machine: Technology, Meaning, Praxis. Steve Berneking & Scott S. Elliott, eds., Nida Institute Conference Papers 2 (Rome: Edizioni di Storia e Letteratura, 2009). ISBN: 978-88-8498-468-5; ABS Item Number: 120710; Retail Price: $45.00. Ordering Information: USA: www.Bibles.com or 1-800-32-BIBLE Canada: www.biblesociety.ca or 800-564-2425 Italy: info@storiaeletteratura.it or (0039) 063 967 0307 All other countries: www.casalini.it or (0039) 055 501 8201 Contact Information: Charles Houser, Editorial & Publications Manager Nida Institute for Biblical Scholarship American Bible Society, 1865 Broadway, New York, NY 10023 Phone (212) 408-1235 / Fax (212) 408-1435 / Email chouser@americanbible.org10.Nuevo libro: Alexander C.Y. Huang. Chinese Shakespeares: Two Centuries of Cultural Exchange. New York: Columbia UP, 2009. ISBN: 978-0-231-14849-8. US$ 23.85. <http://cup.columbia.edu/book/978-0-231-14848-1/chinese-shakespeares>11.Curso de verano:Curso de verano de carácter doctoral organizado por CETRA 2010 en su 22ª edición - Katholieke Universiteit Leuven (KUL), Bélgica, 16 - 28 de agosto de 2010. Profesor invitado de esta edición: Sherry Simon ( http://www.kuleuven.be/cetra/people/sherry_simon.html),Concordia University. Para más información: contactar con Reine Meylaerts: reine.meylaerts@arts.kuleuven.be Visite la web de CETRA: http://www.kuleuven.be/cetra/index/

AbstractLet S be the semigroup S = Σ⊕ki∈1 Si, where for each i∈ I, Si is a countable subsemigroup of the additive semigroup R+ containing 0. We consider representations of S as contractions {Ts} s∈S on a Hilbert space with the Nica-covariance property: T*s Tt = TtT*s whenever t^s = 0. We show that all such representations have a unique minimal isometric Nica-covariant dilation.This result is used to help analyse the nonself-adjoint semicrossed product algebras formed from Nica-covariant representations of the action of S on an operator algebra A by completely contractive endomorphisms. We conclude by calculating the C*-envelope of the isometric nonself-adjoint semicrossed product algebra (in the sense of Kakariadis and Katsoulis).

La anidación de Cichlasoma dovii en la laguna de Xiloá, estudiada a través de la observación directa y usando la técnica de buceo. La especie en estudio anidó entre noviembre y mayo, a profundidades de 7 y hasta 21 metros. La tasa de éxito en el reclutamiento de alevines fue mayor para anidaciones en diciembre. El comportamiento del macho en apareamiento es facultativo: algunos abandonaron el nido al nacer los alevines, otros mantuvieron presencia en o alrededor del nido hasta el reclutamiento de los alevines 0 hasta el fracaso del nido por depredación. Se observó el comportamiento de seis machos con una sola hembra, y de seis machos con dos y hasta cinco hembras cada uno, en anidación simultánea. Se liberaron 360 +/- 333 alevines por nido, entre las edades de 58+1-4 días en situaciones en que el macho participó en el cuido de nido, en seis nidos exitosos de 14 estudiados. Se liberaron 198 +/- 1 17 alevines por nido, entre edades de 60+/- 7 días, en 28 nidos exitosos de 45 estudiados, en situaciones en que no hubo participación del macho. La hembra defiende el nido principalmente contra tres especies: Neetroplus nematopus, Cichlasoma citrinellum, y Gobiomorus dormitor, este último Con invade exitosamente el nido.

Abstract The short-lived hadronic resonances are used to study properties of the hot and dense medium produced in relativistic heavy-ion collisions. Due to their short lifetimes, the resonance yields and masses measured in the hadronic channels are sensitive to rescattering and regeneration effects in the hadronic phase. The measurement of resonances is foreseen in the physical program of the MPD experiment at NICA in heavy-ion collisions at S N N = 4 - 11 GeV , in the range of energies where extensive measurements of resonances are not experimentally available. In this contribution, we explore the sensitivity of the ρ(770)0, K*(892), ϕ(1020), ∑(1385)±, Λ(1520) and Ξ(1530)0 resonances measured in the hadronic decay channels to different stages of the heavy-ion collisions at NICA energies and report the feasibility studies for the reconstruction of resonances in the MPD setup

Three new, substituted, nido carboranes, 7,8-Ph2-10-(SMe2)-7,8-nido-C2B9H10 (1a), 7,8-Ph2-10- (SMeEt)-7,8-nido-C2B9H10 (1b) and 7,8-Ph2-10-(SEt2)-7,8-nido-C2B9H10 (1c) have been synthesised and characterised, including a crystallographic study of the first. Deprotonation of 1a followed by treatment with (MeCN)2(CO)2MoBr(η-C3H5) at 0 °C affords the non-icosahedral 1,2-Ph2-4-(SMe2)-5-(η-C3H5)-5,5-(CO)2-5,1,2-closo-MoC2B9H8 (2a), which on subsequent warming transforms into icosahedral 2,8-Ph2-5-(SMe2)-1-(η-C3H5)-1,1-(CO)2-1,2,8-closo- MoC2B9H8 (3a). It is argued that under the conditions of these rearrangements the B-S bond is likely to remain intact, and consequently that the identity of the SMe2-labelled boron atom in 3a affords useful experimental information on the course of the isomerisation.

A novel family of three types of charged ligand (0, −1, and −2) based neutral phosphorescent iridium(iii) complexes featuring nido-carborane have been prepared and their structures and photophysical properties have been studied.

Reduction of nido-5,6-C2B8H12 with sodium tetrahydroborate in ethanolic sodium hydroxide as a new method for preparing arachno-6,9-C2B8H14 is reported. Electrophilic halogenation of 6,9-C2B8H14 occurs at the B(1) site to give a series of 1-X-6,9-C2B8H13 (X = Cl, Br, and I) derivatives. Stereoselective addition of hydrogen halides to the B(5)-C(6) bond in the [6,9-C2B8H10]2- anion results in the formation of 5-X-6,9-C2B8H13 (X = F, Cl, Br, I and 5'-0-6,9-C2B8H13) compounds. Constitution of all compounds isolated is suggested on the basis of their 1H and 11B NMR data and the effects of halogen substituents on the 11B NMR shielding of individual cage boron atoms are discussed in terms of Δδ and k2 values.

AbstractReactions between the arachno-6,9-C2B8H14 dicarbaborane and acyl chlorides, RCOCl, in the presence of amine bases in CH2Cl2, followed by acidification with conc. H2SO4 at 0 °C, generate in high yields a series of neutral alkyl and aryl tricarbollides of structure 8-R-nido-7,8,9-C3B8H11 (where R=alkyls and aryls). These skeletal alkylcarbonation (SAC) reactions are consistent with an aldol-type condensation between the RCO group and open-face dicarbaborane hydrogen atoms, which is associated with the insertion of the acyl chloride RC unit into the structure under elimination of three extra hydrogen atoms as H2O and HCl. The reactions thus result in an effective cross-coupling between R and the tricarbollide cage. High-temperature reactions between 8-Ar-nido-7,8,9-C3B8H11 (where Ar=Ph, 1-C10H7, and 2-C10H7) compounds and [CpFe(CO)2]2 produced the first types of monoaryl substituted twelve-vertex ferratricarbollide complexes of general constitution [1-(CpFe)-closo-ArC3B8H10] with three different arrangements of cluster carbon vertexes. The Fe-complexation is accompanied by extensive rearrangement of the cluster carbon atoms over the twelve-vertex cage and the complexes isolated can be regarded as ferrocene analogues.

Abstract. In order to better understand the role of A-and B-cell function in diabetic pregnancy, we studied four groups of pregnant women at week 34–36 of gestation. Seventeen were healthy controls (C), 24 had gestational diabetes (GD), 16 had type 2 diabetes (NIDD) and 37 had type 1 diabetes (IDD). At times —20, 0, 20, 30, 45, 60, 90 and 120 min from the beginning of a 30 min infusion of 30 g of arginine intravenously, plasma glucose, glucagon (IRG) and C-peptide (CPR) were measured. Plasma glucose was higher in diabetic than in control subjects. IRG values were also higher in the GD and the NIDD women. CPR values were similar to, or slightly higher than control values in the GD and the NIDD and were much lower in the IDD women. All three variables increased during the arginine infusion in all groups, with the exception that CPR remained unchanged in the IDD. The CPR/IRG molar ratio was similar in control, GD and NIDD women; in the IDD, it was much smaller than in the other groups and was not affected by arginine. In all the diabetic patients, IRG was negatively correlated with the maternal weight gain and in the IDD IRG was positively correlated with the increase in the insulin need and with the CPR levels. In conclusion diabetes appeared to enhance the A-cell function also in pregnancy, possibly impairing the 'facilitated anabolism' and stressing the 'accelerated starvation' which are typical of normal pregnancy. Glucagon was confirmed as one possible determinant of the insulin resistance seen in diabetic pregnancy.

Se investigó la relación entre la preferencia de selección de sitios de anidamiento, la posición jerárquica y el éxito reproductivo del Periquito de anteojos (Forpus conspicillatus) en la Universidad del Valle y en la Reserva Natural Pozo Verde, en el Valle del Cauca, Colombia. Los sitios de anidamiento se instalaron según las variables: altura sobre el suelo (1 m y 4 m) y distancia al árbol más próximo (0 m, 15 m y 50 m). Las parejas de adultos prefirieron las cajas nido ubicadas a 4 m de altura sobre el suelo. La posición jerárquica de las parejas no se correlacionó significativamente con la prioridad de elección de las cajas nido, pero sí con la escogencia de cajas en los sitios preferidos. Las parejas dominantes produjeron un mayor número de huevos que las subordinadas, pero no hubo correlación entre posición jerárquica y número de polluelos que alcanzaron el éxodo. Tampoco se encontró correlación entre productividad anual, medida como el número de polluelos que llegaron al éxodo y la ubicación de las cajas nido. La ausencia de correlación pudo deberse a que la depredación, la principal causa de mortalidad de polluelos, tuvo igual incidencia en todas las situaciones. El infanticidio por Troglodytes aëdon fue responsable del 30.30% de los fracasos de los nidos de F. conspicillatus, pero los daños por T. aëdon no fueron más frecuentes en los sitios preferidos por F. conspicillatus.

ObjectiveTo determine long term safety and efficacy of endovascular treatment of spinal cord arteriovenous malformations (AVMs), with calibrated particle embolization as a firstline approach.MethodsWe reviewed clinical and imaging data of consecutive patients who underwent endovascular treatment for both nidal and fistulous type spinal cord AVMs in our center, from 1990 to 2015. Outcome at the last follow-up was assessed by an independent observer.ResultsEmbolization of spinal cord AVMs was performed in 61 patients, including 46 (75%) with particles (exclusively in 29 patients), 30 (49%) with cyanoacrylate, and 6 (10%) with combined surgical treatments. Particle embolizations were iterative in 33 patients (median number of sessions 5 (range 3–6)). Neurological deterioration after treatment occurred in 5 patients (cyanoacrylate=4, surgery=1, particles=0; P<0.001). At a median follow-up of 6 years (range 3–13 years), angiographic cure was obtained in 11/61 (18%) patients (nidal type=6/53 (11%), fistulous type=5/8 (63%)). In progressive forms, neurological improvement occurred in 16/28 (57%) patients, stabilized in 9/28 (31%), and worsened in 3/28 (12%). In hemorrhagic forms, the rebleeding rate was 4/14 patient years without standard treatment, 0/322 patient years in partial iterative treatment, and 0/15 patient years in angiographically cured lesions (P=0.001).ConclusionOur study suggests that particle embolization as a firstline therapy to treat spinal cord AVMs is safe and offers long term efficacy, especially for those with small, distal, and multiple shunts. Partial occlusion of the AVM may be sufficient to prevent rebleeding, without the potential risks of complete occlusion. Particle calibration and injection technique, ‘one by one’, are critical to safety. Cyanoacrylate embolization or surgery remains necessary if particle embolization fails to occlude large shunts.

El objetivo del presente estudio es analizar la seguridad (1 = Sí cumple, 0 = No cumple) de las instalaciones y equipamientos deportivos de centros educativos de la ciudad de Mérida en base a la normativa NIDE y UNE-EN. De forma complementaria se valora su utilización (1 = Sí utilizaría, 0 = No utilizaría), riesgo y estado general de conservación (escala del 1 al 5). Todas las variables del estudio son registradas de acuerdo al check list elaborado por Herrador y Latorre (2008). Un total de 26 centros educativos fueron analizados, de los que se cumplimentaron 2611 ítems. Los resultados muestran que el porcentaje medio de seguridad es del 54%, con una valoración de utilización del 85%. Además, la valoración del riesgo y estado de conservación alcanza el 2.26 y 3.71 respectivamente. Existen diferencias en las variables de estudio según el Tipo de instalación y equipamiento deportivo. Destacar que las instalaciones cubiertas tienen mayor porcentaje de seguridad (69%) y valoración de conservación (3.67) mientras que las descubiertas obtienen mayor valoración de riesgo (2.52). Las canastas alcanzan más seguridad (53%), valoración de utilización (2.39) y conservación (4). Se recomienda mejorar la formación del docente de Educación Física en materia de seguridad de instalaciones deportivas e implementar medidas concretas de seguridad en la gestión y uso de las instalaciones y equipamientos deportivos de los centros ya que la práctica físico-deportiva no está totalmente garantizada.Abstrac. The aim of this study is to analyze the security (1= Yes, it meets, 0= No, it fails) of sports facilities and equipment of schools in Merida, in accordance with NIDE and UNE-EN regulations. Additionally it is also assessed their use (1= Yes, I would use it, 0= No, I would not use it), the risk and the general state of conservation (scale from 1 to 5). To reach our objectives, all variables in our study are recorded according to the check list developed by Herrador and Latorre (2008). 26 schools were analyzed, completing 2611 items. The results show a safety average percentage of 54%, with an utilization rating of 85%. In addition, the risk assessment and the state of conservation reach 2.26 and 3.71 respectively. There are differences in the variables of study according to the Type of sport facility and sport equipment. It should be pointed out that the indoor facilities have higher security percentage (69%) and conservation assessment (3.67) while the outdoor facilities have higher risk assessment (2.52). Baskets are safer (53%), evaluation of utilization (2.39) and conservation (4). Likewise, it is recommended to enhance the education of the teacher of Physical Education in security issues and implement safety measures in the management and use of sports facilities and equipment in the schools because the sport physical practice is not fully guaranteed.

Introduction: Chemotherapy-induced nausea and vomiting (CINV) is a common and distressing side effect that has a detrimental impact on QoL. For pts receiving highly emetogenic chemotherapy (HEC), which includes those on anthracycline-cyclophosphamide (AC)-based regimens, a triple combination of a neurokinin-1 receptor antagonist (NK1 RA), a 5-hydroxytryptamine-3 (5-HT3) RA and dexamethasone is recommended by the NCCN and MASCC/ESMO. The complexity of the NK1 RA-based schedules may be a reason for the low adherence to antiemetic guidelines and a not sufficient control of CINV in pts receiving HEC and MEC. NEPA is the only available fixed-combination antiemetic. It is composed of an NK1 RA, netupitant (300 mg) and a 5-HT3 RA, palonosetron (0.50 mg); thus, it acts by blocking two main emetic pathways in a single dose and eases compliance to guidelines. Methods: Prospective, non-interventional study at 162 sites in Germany from 09/2015 to 03/2018. The aim was to determine QoL of adult cancer pts receiving NEPA for the prevention of nausea and vomiting associated with 1 or 2 day HEC or MEC in daily clinical practice. The primary outcome was measured via the Functional Living Index-Emesis (FLIE) questionnaire. FLIE questionnaires were analyzed according to the FLIE scoring and administration manual v12; higher scores correlated to better performance on daily life activities due to the lower occurrence of nausea and vomiting. 'No impact on daily life (NIDL) activities' for individual nausea and vomiting domains was defined as a FLIE score higher than 53.8; NIDL for the combined domains of nausea and vomiting was defined as a FLIE score higher than 108. Secondary objectives included evaluating effectiveness, as determined by measuring the rate of complete response (CR) and rescue medication, as well as safety outcomes. Efficacy was documented by the treating physicians and via patient diaries for 3 Ctx cycles within 24 hrs and on 4 additional d after Ctx. Safety, additional medication and physicians' overall satisfaction was reported via eCRF. Results: A total of 2429 pts were enrolled, 2405 of whom were assessed for eligibility; of these, 2173 were included in the final analysis and constitute the full analysis set population (FAS). Evaluable FLIE questionnaires were collected from 1886 (88%) pts in cycle 1, 1795 (88%) pts in cycle 2 and 1698 (86%) pts in cycle 3. A total of 1389 pts received HEC and 764 MEC in cycle 1. The majority of pts (91%) were scheduled to receive 1-day ctx at study entry. More than half of the pts (1230, 56%) received anthracycline/cyclophosphamide-(AC), 19% carboplatin-, 8% cisplatin-, 7% oxaliplatin- and 9% other CTs. NIDL due to vomiting during cycle 1 was reported by 84% of pts in the HEC group and 82% in the MEC group. These frequencies were maintained in cycles 2 and 3. NIDL due to nausea increased from 54% in cycle 1 to 58% in cycle 3 for pts receiving HEC, and from 59% in cycle 1 to 66% in cycle 3 for pts in the MEC group. The rates for the combined domain of NIDL due to nausea and vomiting were consistent across cycle 1 (64%) and in cycles 2 and 3 (66% in each cycle) for pts in the HEC group, while the rates increased from 67% in cycle 1 to 73 and 74% in cycles 2 and 3, respectively, for pts receiving MEC. The CR rate (no emesis and no use of rescue medication) was 89% in the acute phase (0-24 h), 87% in the delayed phase (25-120 h) and 83% in the overall period (0-120 h) in cycle 1. The no significant nausea (NSN) rate was 79 % in the acute, 75 % in the delayed and 67 % in the overall phase in cycle. The majority of physicians (≥89%) and pts (≥86%) rated the effectiveness of NEPA prophylaxis as 'very good' or 'good' during all three ctx cycles. The most common NEPA-related AEs, which occurred in &gt;1% of pts in the overall study period, were fatigue (3%), constipation (3%), nausea (2%) and insomnia (2%). There were no reports of NEPA-related deaths. Conclusions: Real-life data show that NEPA was effective in the prevention of chemotherapy-induced nausea and vomiting in cancer patients. NEPA had beneficial effects on the quality of life and was highly effective in the acute and delayed phase of HEC and MEC. NEPA antiemetic effectiveness was rated highly both by patients and physicians. Disclosures Karthaus: RIEMSER: Consultancy, Honoraria. Schilling:Riemser: Honoraria.

We compute spectra and Brown measures of some non self-adjoint operators in $(M_2(\mathsf {C}), \frac{1}{2}\mathrm{Tr})*(M_2(\mathsf{C}), \frac{1}{2}\mathrm{Tr})$, the reduced free product von Neumann algebra of $M_2(\mathsf {C})$ with $M_2(\mathsf {C})$. Examples include $AB$ and $A+B$, where $A$ and $B$ are matrices in $(M_2(\mathsf {C}), \frac{1}{2}\mathrm{Tr})*1$ and $1*(M_2(\mathsf {C}), \frac{1}{2}\mathrm{Tr})$, respectively. We prove that $AB$ is an R-diagonal operator (in the sense of Nica and Speicher [12]) if and only if $\mathrm{Tr}(A)=\mathrm{Tr}(B)=0$. We show that if $X=AB$ or $X=A+B$ and $A,B$ are not scalar matrices, then the Brown measure of $X$ is not concentrated on a single point. By a theorem of Haagerup and Schultz [9], we obtain that if $X=AB$ or $X=A+B$ and $X\neq \lambda 1$, then $X$ has a nontrivial hyperinvariant subspace affiliated with $(M_2(\mathsf{C}), \frac{1}{2}\mathrm{Tr})*(M_2(\mathsf{C}), \frac{1}{2}\mathrm{Tr})$.

Bis(carboranyl)amides 1,1′-μ-(CH2NH(O)C(CH2)n-1,2-C2B10H11)2 (n = 0, 1) were prepared by the reactions of the corresponding carboranyl acyl chlorides with ethylenediamine. Crystal molecular structure of 1,1′-μ-(CH2NH(O)C-1,2-C2B10H11)2 was determined by single crystal X-ray diffraction. Treatment of bis(carboranyl)amides 1,1′-μ-(CH2NH(O)C(CH2)n-1,2-C2B10H11)2 with ammonium or cesium fluoride results in partial deboronation of the ortho-carborane cages to the nido-carborane ones with formation of [7,7′(8′)-μ-(CH2NH(O)C(CH2)n-7,8-C2B9H11)2]2−. The attempted reaction of [7,7′(8′)-μ-(CH2NH(O)CCH2-7,8-C2B9H11)2]2− with GdCl3 in 1,2-dimethoxy- ethane did not give the expected metallacarborane. The stability of different conformations of Gd-containing metallacarboranes has been estimated by quantum-chemical calculations using [3,3-μ-DME-3,3′-Gd(1,2-C2B9H11)2]− as a model. It was found that in the most stable conformation the CH groups of the dicarbollide ligands are in anti,anti-orientation with respect to the DME ligand, while any rotation of the dicarbollide ligand reduces the stability of the system. This makes it possible to rationalize the design of carborane ligands for the synthesis of gadolinium metallacarboranes on their base.

Abstract Given adipose tissue is histologically classified as connective tissue, we hypothesized expression of extracellular matrix (ECM) components are significantly altered during adipogenesis. However, little is known about the regulation of the ECM during adipose tissue development in the pig. Therefore, the objective of this study was to characterize expression of ECM components during porcine adipogenesis. Primary cultures of adipose tissue stromal-vascular cells were harvested from 3-day-old neonatal pigs (n=6) and preadipocytes induced to differentiate in vitro for 8 days in the presence of insulin, hydrocortisone, and rosiglitazone. Total RNA was extracted from these cultures on days 0 and 8 post-induction. Real-time PCR was then utilized to determine changes in mRNA expression for collagen type I alpha 1 chain (COL1A), collagen type I alpha 2 chain (COL2A), collagen type I alpha 3 chain (COL3A), collagen type I alpha 4 chain (COL4A), collagen type I alpha 6 chain (COL6A), biglycan, fibronectin, laminin, nitogen-1 (NID1), matrix metallopeptidase 2 (MMP2), matrix metallopeptidase 9 (MMP9), metallopeptidase inhibitor 3 (TIMP3). The mRNA abundances of COL1A, COL3A and MMP2 were significantly downregulated 2.86-fold (P &lt; 0.05), 16.7-fold (P &lt; 0.01) and 3.1-fold (P &lt; 0.05) respectively in day 8 (differentiated) compared to day 0 (undifferentiated) cultures. Meanwhile, mRNA abundances were significantly upregulated during adipogenesis for the COL2A (2.82-fold; P &lt; 0.05), COL4A (2.01-fold; P &lt; 0.05), COL6A (2.8-fold; P &lt; 0.05), biglycan (49.9- fold; P &lt; 0.001), fibronectin (452-fold; P &lt; 0.001), laminin (6.1-fold; P &lt; 0.05), NID1(47.4-fold; P &lt; 0.01), MMP9 (76.8- fold; P &lt; 0.01), and TIMP3(3.04-fold; P &lt; 0.05) genes. These data support the hypothesis that significant changes in ECM components occur during porcine adipogenesis. Modulating adipose tissue ECM remodeling might be a novel strategy to manipulate adiposity in the pig.

One of the main physics goals of the Multi Purpose Detector (MPD) is to investigate hot and dense baryonic matter in heavy ion collisions at NICA energies to search for the possible critical end point (CEP). Since the location of CEP is not clear the entire accessible region of the QCD phase diagram needs to be explored by scanning the full range of available beam energies. In case of CEP existence it can be observed by abnormal fluctuations of various quantities such as net-proton multiplicity. This task requires excellent particle identification (PID) capability over as large as possible phase space volume. The identification of charged hadrons is achieved at the momenta of 0:1 – 3 GeV/c. The results of hadron identification and preliminary possibility estimation of the study of event-by-event fluctuations at MPD will be presented.

NOTICIAS / NEWS (“Transfer”, 2015) 1) CONGRESOS / CONFERENCES: 1. First Forlì International Workshop – Corpus-based Interpreting Studies: The State of the Art University of Bologna at Forlì, 7-8 May 2015. http://eventi.sslmit.unibo.it/cis1/<file:///owa/redir.aspx 2. 5th IATIS Conference – Innovation Paths in Translation and Intercultural Studies, Belo Horizonte, Brazil, 7-10 July 2015. www.iatis.org/index.php/iatis-belo-horizonte-conference/itemlist/category/168-call-for-communication-proposals-within-the-general-conference 3. POETRY/TRANSLATION/FILM – POÉSIE/TRADUCTION/FILM PoeTransFi, Paul Valéry University, Montpellier, France, 18-19 June 2015. http://pays-anglophones.upv.univ-montp3.fr/?page_id=1795 4. 6th International Maastricht-Lodz Duo Colloquium on “Translation and Meaning”, Maastricht School of Translation & Interpre-ting, Zuyd University of Applied Sciences, Maastricht, Netherlands 21-22 May 2015. www.translation-and-meaning.nl 5. MiddleWOmen. Networking and cultural mediation with and between women (1850-1950). Centre for Reception Studies (CERES), HERA Travelling TexTs project and Huygens ING KU Leuven campus Brussels 7-8 May 2015. www.receptionstudies.be 6. 5th International Symposium: Respeaking, Live Subtitling and Accessibility, Università degli Studi Internazionali di Roma, Italy, 12 June 2015. www.unint.eu/it/component/content/article/8-pagina/494-respeaking-live-subtitling-and-accessibility.html 7. Conference on Law, Translation and Culture (LTC5) and Legal and Institutional Translation Seminar, University of Geneva, Switzerland 24-26 June 2015. www.unige.ch/traduction-interpretation/recherches/groupes/transius/conference2015_en.html 8. 6th International Conference Media for All – Audiovisual Translation and Media Accessibility: Global Challenges, University of Western Sydney, Australia, 16-18 September 2015. http://uws.edu.au/mediaforall 9. Translation in Exile, Vrije Universiteit Brussel, 10-11 December 2015. www.cliv.be 10. Literary Translation as Creation, Université d’Avignon et des Pays de Vaucluse, 20-21 May 2015. laurence.belingard@univ-avignon.fr marie-francoise.sanconie@univ-avignon.fr 11. 4th International Conference on Language, Medias and Culture (ICLMC 2015) 9-10 April 2015. Kyoto, Japan, www.iclmc.org 12. 9th International Colloquium on Translation Studies in Portugal – Translation & Revolution, Universidade Católica Portuguesa, Lisbon, 22-23 October 2015. ix.translation.revolution@gmail.com 13. Translation as Collaboration: Translaboration?, University of Westminster, London, 18 June 2015 Contact: Alexa Alfer (A.Alfer01@westminster.ac.uk), Steven Cranfield (S.Cranfield@westminster.ac.uk), Paresh Kathrani (P.Kathrani@westminster.ac.uk) 14. Translation/Interpreting Teaching and the Bologna Process: Pathways between Unity and Diversity, FTSK Germersheim, Germany 27–29 November 2015. www.fb06.uni-mainz.de/did2015/index_ENG.php 15. Atlantic Communities: Translation, Mobility, Hospitality, University of Vigo, Spain, 17-18 September 2015. http://translating.hypotheses.org/551 16. Exploring the Literary World III: Transgression and Translation in Literature Chulalongkorn University, Bangkok, Thailand 23-24 April 2015. www.arts.chula.ac.th/~complit/complite/?q=conference 17. Authenticity and Imitation in Translation and Culture, University of Social Sciences and Humanities, Warsaw, Poland, 7 – 9 May 2015. www.swps.pl/english-version/news/conferences/12164-authenticity-and-imitation-in-translation-and-culture 18. Translation in Transition, Barnard College, New York City, USA 1-2 May 2015. barnard.edu/translation/translation-in-transition 19. First Forlì International Workshop – Corpus-based Interpreting Studies: The state of the art, University of Bologna at Forlì, Italy, 7-8 May 2015. http://eventi.sslmit.unibo.it/cis1 20. Translation and Meaning. The Lodz Session of the 6th International Maastricht-Lodz Duo Colloquium, University of Lodz, Poland, 18-19 September 2015. http://duo.uni.lodz.pl 21. TAO-CAT-2015, Université Catholique de l’Ouest, Angers, France 28-30 May 2015. www.tao2015.org/home-new 22. English Language and Literary Studies (ELLS 2015), Chulalongkorn University, Bangkok, Thailand, 3-4 August 2015. http://ells2015.com 23. Talking to the World 2: The Relevance of Translation and Interpreting – Past, Present and Future, Newcastle University, UK, 10-11 September 2015. www.ncl.ac.uk/sml/study/postgraduate/T&I/2015conference/main.htm 24. 6th International Symposium for Young Researchers in Translation, Interpreting, Intercultural Studies and East Asian Studies Universitat Autònoma de Barcelona, Spain, 3 July 2015. www.fti.uab.es/departament/simposi-2015/en/index.htm 25. Portsmouth Translation Conference: Border Crossing or Border Creation?, University of Portsmouth, UK, 14 November 2015. www.port.ac.uk/translation/events/conference 26. New Perspectives in Assessment in Translation Training: Bridging the Gap between Academic and Professional Assessment, University of Westminster, London, UK, 4 September 2015. www.westminster.ac.uk/news-and-events/events/humanities/archive/2014/mlc/new-perspectives-in-assessment-in-translation-training-bridging-the-gap-between-academic-and-professional-assessment 27. III Congreso Internacional de Neología en las Lenguas Románicas University of Salamanca, 22-24 October 2015. http://diarium.usal.es/cineo2015 28. Some Holmes and Popovič in all of us? The Low Countries and the Nitra Schools in the 21st century, Constantine the Philosopher University, Nitra, Slovakia, 8-10 October 2015. Contact: igor.tyss@gmail.com 29. The Cultural Politics of Translation, Cairo, Egypt, 27-29 October 2015. https://culturalpoliticstranslation2015.wordpress.com 30. Journée d’étude « le(s) figure(s) du traducteur », Mount Royal University, Calgary, Canada, 30 April 2015. http://mrujs.mtroyal.ca/index.php/cf/index 31. Mediterranean Editors and Translators Annual Meeting —Versatility and readiness for new challenges, University of Coimbra, Portugal, 29-31 October 2015. www.metmeetings.org/en/preliminary-program:722 32. Lengua, Literatura y Traducción “liLETRAd”, University of Seville, Spain, 7-8 July 2015. http://congreso.us.es/liletrad. 33. Meta: Translators' Journal is celebrating its 60th anniversary in 2015! For the occasion, an anniversary colloquium will be held on August 19th to 21st, 2015 at the Université de Montréal (Montréal, Canada). Colloquium for the 60th Anniversary of META – 1955-2015: Les horizons de la traduction: retour vers le futur. Translation’s horizons: back to the future. Los horizontes de la traducción: regreso al futuro, August 19-21, 2015 – Université de Montréal. Please send your proposal to this address: meta60e@gmail.com, to the attention of Georges L. Bastin or Eve-Marie Gendron-Pontbrian 2) CURSOS DE POSGRADO / MASTERS: 1. Legal Translation, Master universitario di II livello in Traduzione Giuridica University of Trieste, Italy. http://apps.units.it/Sitedirectory/InformazioniSpecificheCdS/Default.aspx?cdsid=10374&ordinamento=2012&sede=1&int=web&lingua=15 2. Traducción Especializada, Universitat Oberta de Catalunya (UOC), Spain. http://estudios.uoc.edu/es/masters-posgrados-especializaciones/master/artes-humanidades/traduccion-especializada/presentacion 3. Online course: La Traducción Audiovisual y el Aprendizaje de Lenguas Extranjeras, Universidad Nacional de Educación a Distancia, Madrid, 1st December 2014 to 31st May 2015. http://formacionpermanente.uned.es/tp_actividad/idactividad/7385 https://canal.uned.es/mmobj/index/id/21174 Contact: Noa Talaván (ntalavan@flog.uned.es), José Javier Ávila (javila@flog.uned.es) 4. Online course: Audio Description and Its Use in the Foreign Language Classroom, UNED, Madrid, Spain http://formacionpermanente.uned.es/tp_actividad/idactividad/7492 5. Online course: Curso de Formación de Profesorado, La Traducción Audiovisual y el Aprendizaje de Lenguas Extranjeras UNED, Madrid, Spain. http://formacionpermanente.uned.es/tp_actividad/idactividad/7385 6. EST Training Seminar for Translation Teachers, Kraków, Poland 29 June – 3 July 2015. www.est-translationstudies.org/events/2015_seminar_teachers/index.html 7. Train the Trainer -Teaching MT: EAMT-funded Workshop, Dublin City University, 30 April- 1 May 2015. https://cttsdcu.wordpress.com/eamt-workshop-on-teaching-mt-to-translator-trainers-30-april-1-may 3) CURSOS DE VERANO / SUMMER COURSES: 1. 2015 Nida School of Translation Studies, Leading Edges in Translation: World Literature and Performativity, San Pellegrino University Foundation campus, Misano Adriatico, Italy, 18-29 may 2015. http://nsts.fusp.it/Nida-Schools/NSTS-2015 2. EMUNI Translation Studies Doctoral and Teacher Training Summer School, University of Turku, Finland, 1-12 June 2015. www.utu.fi/en/units/hum/units/languages/EASS/Pages/home.aspx 3. Chinese-English Translation and Interpretation, School of Translation and Interpretation, University of Ottawa, Canada, 13th July – 7th August 7 2015. http://arts.uottawa.ca/translation/summer-programs 4. Summer Program in Translation Pedagogy, University of Ottawa 13 July – 7 August 2015. http://arts.uottawa.ca/translation/summer-programs 4) LIBROS / BOOKS: 1. Audio Description: New Perspectives Illustrated, Edited by Anna Maszerowska, Anna Matamala and Pilar Orero, John Benjamins, 2014. https://benjamins.com/#catalog/books/btl.112/main 2. Call for papers: Translation Studies in Africa and beyond: Reconsidering the Postcolony, Editors: J Marais & AE Feinauer Contacts: Kobus Marais (jmarais@ufs.ac.za) or Ilse Feinauer (aef@sun.ac.za). 4. Measuring live subtitling quality: Results from the second sampling exercise, Ofcom, UK. http://stakeholders.ofcom.org.uk/consultations/subtitling/sampling-results-2 5. A Training Handbook for Legal and Court Interpreters in Australia by Mary Vasilakakos, ISBN 978-0-9925873-0-7, Publisher: Language Experts Pty Ltd. www.interpreterrevalidationtraining.com www.languageexperts.com.au 6. Call for papers: Opera and Translation: Eastern and Western Perspectives, Edited by Adriana Serban and Kelly Kar Yue Chan http://pays-anglophones.upv.univ-montp3.fr/?page_id=1908 7. The Known Unknowns of Translation Studies, Edited by Elke Brems, Reine Meylaerts and Luc van Doorslaer, Amsterdam/Philadelphia: John Benjamins, 2014. https://benjamins.com/#catalog/books/bct.69/main 8. Translating the Voices of Theory/ La traduction des voi de la théorie Edited by Isabelle Génin and Ida Klitgård, 2014. www.hf.uio.no/ilos/english/research/groups/Voice-in-Translation/ 9. Authorial and Editorial Voices in Translation 1 - Collaborative Relationships between Authors, Translators, and Performers, Eds. Hanne Jansen and Anna Wegener, 2014. http://editionsquebecoisesdeloeuvre.ca/data/documents/AEVA-Flyer-1-190895-Vita-Traductiva-Vol-2-Flyer-EN-100413.pdf 10. Authorial and Editorial Voices in Translation 2 - Editorial and Publishing Practices, Eds. Hanne Jansen and Anna Wegener, 2014. www.editionsquebecoisesdeloeuvre.ca/accueil 11. Call for papers: Achieving Consilience. Translation Theories and Practice. https://cfpachievingconsilience.wordpress.com 12. Framing the Interpreter. Towards a visual perspective. Anxo Fernández-Ocampo & Michaela Wolf (eds.), 2014, London: Routledge. http://routledge-ny.com/books/details/9780415712743 13. Multilingual Information Management: Information, Technology and Translators, Ximo Granell, 2014. http://store.elsevier.com/Multilingual-Information-Management/Ximo-Granell-/isbn-9781843347712/ 14. Writing and Translating Francophone Discourse: Africa, The Caribbean, Diaspora, Paul F. Bandia (ed.), 2014, Amsterdam, Rodopi www.brill.com/products/book/writing-and-translating-francophone-discourse 15. Call for papers (collective volumen): Translation studies in Africa and beyond: Reconsidering the postcolony www.facebook.com/notes/mona-baker/translation-studies-in-africa-and-beyond-reconsidering-the-postcolony/743564399051495 16. Audiovisual Translation in the Digital Age - The Italian Fansubbing Phenomenon, By Serenella Massidda, Palgrave Connect, 2015. www.palgrave.com/page/detail/audiovisual-translation-in-the-digital-age-serenella-massidda/?k=9781137470362 17. Video: First International SOS-VICS Conference - Building communication bridges in gender violence, University of Vigo, Spain 25-26 September 2014. http://cuautla.uvigo.es/CONSOS/ 18. Camps, Assumpta. Traducción y recepción de la literatura italiana, Publicacions i Edicions UB, 2014. ISBN: 978-84-475-3776-1. 19. Camps, Assumpta. Italia en la prensa periódica durante el franquismo, Publicacions i Edicions UB, 2014. ISBN: 978-84-475-3753-2. 5) REVISTAS / JOURNALS: Call for papers: “Altre Modernità – Rivista di studi letterarie e culturali” Special Issue: Ideological Manipulation in Audiovisual Translation, Contact: irene.ranzato@uniroma.it. http://riviste.unimi.it/index.php/AMonline/announcement/view/381 2. Call for papers: “Between, Journal of the Italian Association of Comparative Literature”. Special issue on censorship and self-censorship. http://ojs.unica.it/index.php/between/pages/view/CFP9_censura_auto-censura 3. Open access journal, “Hieronymus, A Journal of Translation Studies and Terminology”, Croatia. www.ffzg.unizg.hr/hieronymus 4. “DIE SCHNAKE. Zeitschrift für Sprachkritik, Satire, Literatur”, Number 39+40, Kleines ABC des Literaturübersetzens. www.rainer-kohlmayer.de 5. Call for papers: “MonTI” 8 (2016) - Economic, Financial and Business Translation: from Theory to Training and Professional Practice. http://dti.ua.es/es/monti-english/monti-authors.html daniel.gallego@ua.es 6. Call for papers: “LINGUISTICA ANTVERPIENSIA”, NEW SERIES -Themes in Translation Studies (15/2016). Interpreting in Conflict Situations and in Conflict Zones throughout History. https://lans.ua.ac.be/index.php/LANS-TTS/announcement 7. Call for papers: “CULTUS: The Journal of Intercultural Mediation and Communication” (8/2016). The Intercultural Question and the Interpreting Professions. www.cultusjournal.com 8. Call for papers: “The Journal of Specialised Translation” Non-thematic issue, Issue 26, July 2016. www.jostrans.org 9. “TranscUlturAl: A journal of Translation and Culture Studies”, Special issue Translating Street Art. http://ejournals.library.ualberta.ca/index.php/TC/issue/view/1634 10. “Przekładaniec 28: Audiodeskrypcja [Audio Description]”, edited by Anna Jankowska and Agnieszka Szarkowska. All papers are published in Polish, with English abstracts. www.ejournals.eu/Przekladaniec/zakladka/66/ 11. Call for papers: “Lingvisticæ Investigationes”, Special issue on Spanish Phraseology: Varieties and Variations. http://dti.ua.es/es/documentos/li-call-for-papers-spanish-phraseology-varieties-and-variations.pdf Further details: Pedro.mogorron@ua.es; xblancoe@gmail.com 13. Call for papers: “Revista de Lenguas para Fines Específicos”, Special issue on The Translation of Advertising. Contact: Laura Cruz (lcruz@dis.ulpgc.es). Deadline: 20th July 2015. www.webs.ulpgc.es/lfe 14. “The AALITRA Review”. www.nla.gov.au/openpublish/index.php/ALLITRA 15. “Current Trends in Translation Teaching and Learning E” www.cttl.org/cttl-e-2014.html 16. Call for papers: “Current Trends in Translation Teaching and Learning E”. www.cttl.org 18. Call for papers: “Translation and Translanguaging in Multilingual Contexts”, Volume 1, Number 2, 2015 Deadline: 10-Jan-2015. https://benjamins.com/#catalog/journals/ttmc/main 19. Call for book reviews: “TRANS. Revista de Traductología,” vol.19, 2015. Deadline: Friday, 30th January 2015. www.trans.uma.es trans@uma.es 20. Call for papers: “a journal of literature, culture and literary Translation”. Special volume – Utopia and Political Theology Today Deadline: 15th January 2015. Contact: sic.journal.contact@gmail.com https://owl.english.purdue.edu/owl/resource/747/01 21. “trans-kom”. www.trans-kom.eu 22. “Linguistica Antverpiensia” NS-TTS 13/2014: Multilingualism at the cinema and on stage: A translation perspective, Edited by Reine Meylaerts and Adriana Şerban. https://lans-tts.uantwerpen.be/index.php/LANS-TTS/issue/current 23. Call for papers: 5th issue (2015) of “Estudios de Traducción”, Deadline: 20 February 2015. www.ucm.es/iulmyt/revista 24. Call for papers: “Journal of Translation Studies” - special issue on Translator & Interpreter Education in East Asia. KATS (Korean Association of Translation Studies), www.kats.or.kr (Go to 'English' page). Contact: Won Jun Nam (wonjun_nam@daum.net, wjnam@hufs.ac.kr). 25. “The Journal of Specialised Translation”, 23, January 2015. www.jostrans.org 26. Call for papers: “TranscUlturAl: A Journal of Translation and Cultural Studies”. Deadline: 15 March 2015. http://ejournals.library.ualberta.ca/index.php/TC/announcement 27. “New Voices in Translation Studies”, Issue 11 (Fall 2014). www.iatis.org/index.php/publications/new-voices-in-translation-studies/item/1034-issue11-2014 28. “The Interpreter and Translator Trainer”, 8:3 (2014). Special issue: Dialogue Interpreting in practice: bridging the gap between empirical research and interpreter education E. Davitti and S. Pasquandrea (eds.) www.tandfonline.com/toc/ritt20/current#.VLQHuyvF-So 6) WEBS DE INTERÉS / WEBSITES OF INTEREST: 1. Support Spanish interpreters to secure the right to translation and interpreting in criminal proceedings: www.change.org/p/pablo-casado-retiren-el-proyecto-de-ley-org%C3%A1nica-que-modifica-la-lecrim

We study the dynamics of a two-site model in which the tunneling amplitude between the sites is not constant, but rather a high-frequency noise. Obviously, the population imbalance in this model decays exponentially with time. Remarkably, the decay is modified dramatically when the level asymmetry fluctuates in-phase with fluctuations of the tunneling amplitude. For a particular type of these in-phase fluctuations, namely, the telegraph noise, we find the exact solution for the average population dynamics. It appears that the population imbalance between the sites starting from 1 at time t = 0 approaches a constant value in the limit [Formula: see text]. At finite bias, the imbalance goes to zero at [Formula: see text], while the dynamics of the decay governed by noise acquires an oscillatory character.

O estado de Minas Gerais é responsável por grande parte da produção cafeeira do país. A constatação da necessidade de encontrar tecnologias sustentáveis para lidar com a quantidade de resíduos gerados por essa demanda de café na região faz surgir esta pesquisa. O objetivo do estudo foi o desenvolvimento de bloquetes por meio de um concreto verde com a adição de cinzas da casca de café separada de qualquer matéria orgânica e em substituição de parte do cimento. Foram determinados os traços de concreto em que parte do cimento foi substituída em pelas cinzas da palha de café. Para tanto, foi feita uma análise estatística, na qual foi necessário um planejamento fatorial de experimentos do tipo 2k, sendo k o número de fatores, com dois níveis para cada fator. Os corpos-de-prova foram moldados com traço de 1:1 (Areia, Pó de brita) com substituição de 0%, 12,5%, 25%, 37,5% e 50% do volume do cimento pelas cinzas da casca de café.

Abstract Objective: Analysis of visual acuity parameters in patients with moderate to high myopia and myopic astigmatism 1 year after treatment with phakic intraocular lenses. Material and methods: This was a retrospective study on 35 patients (52 eyes) with moderate to high myopia who were implanted with the Visian V4c phakic implantable Collamer lens (Staar Surgical, Nidau, Switzerland). Examined parameters were: uncorrected distance visual acuity (UDVA) and best corrected visual acuity (CDVA), manifest and cycloplegic refraction, intraocular pressure, and endothelial cell count. The investigated parameters were measured preoperatively, 1, 3, 6 and 12 months postoperatively. Results: In 17 patients, phakic lenses were implanted binocularly and in 18 patients monocularly. Preoperatively 34.62% of patients had CDVA from 0.9 to 1.0. One year after the surgery 48.08% of patients had UDVA from 0.9 to 1.0. Preoperatively 80.77% of patients had diopter range from -6.00 Dsph to -10.00 Dsph. At 1 year postoperatively 78.85% of patients were within 0.00 Dsph to -1.00 Dsph. Preoperatively, in patients with astigmatism -4 Dcyl to -2 Dcyl dominated, as opposed to significant improvement postoperatively when 94.23% had astigmatism ranging from -1.0 Dcyl to 0 Dcyl. Conclusion: The implantation of phakic lenses demonstrated a successful postoperative outcome in the treatment of myopia and myopic astigmatism. Visual acuity and refraction show a gradual and significant improvement in visual function parameters within 1 year of lens implantation.

Adverse cardiac events are a major cause of late-stage drug development withdrawals. Improved in vitro systems for predicting cardiotoxicity are of great interest to prevent these events and to reduce the expenses involved in the introduction of cardiac drugs into the marketplace. Interdigitated electrodes (IDEs) affixed with a culture well provide a simple, suitable solution for in vitro analysis of cells because of their high sensitivity, ease of fabrication, and label-free, nondestructive analysis. Culturing human pluripotent stem cell differentiated cardiomyocytes onto these IDEs allows for the use of the IDE–cell combination in predictive toxicity assays. IDEs with smaller interdigitated distances allow for greater sensitivity, but typically require cleanroom fabrication. In this communication, we report the definition of a simple IDE geometry on a printed nanostructured substrate, demonstrate a Cellular Index (CI) increase from 0 to 7.7 for human cardiomyocytes, and a decrease in CI from 2.3 to 1 with increased concentration of the model drug, norepinephrine. The nanostructuring results in an increased sensitivity of our 1 mm pitch IDEs when compared to traditionally fabricated IDEs with a pitch of 10 μm (100 times larger electrode gap). The entire nanostructured IDE (nIDE) is fabricated and assembled in a rapid nanofabrication environment, thus allowing for iterative design changes and robust fabrication of devices.

Se determinó la proporción de zonas verdes con presencia de nidos y el nivel de infestación de la hormiga arriera, Atta cephalotes, en tres comunas del municipio de Cali. Entre marzo y abril de 2002, se evaluaron 143 zonas verdes entre parques, separadores de calle, jarillones y polideportivos, cubriendo un área de 1.276.131 m2. La mayor proporción (89%) de las zonas verdes tuvo una intensidad de infestación baja-media; es decir que la mitad ó menos de su área total estaba ocupada por nidos de hormigas. El restante (11%) presentó infestación alta, en la cual más de la mitad del área fue colonizada por arriera. El 68% de los nidos se ubicó en terrenos planos naturales, seguido de zonas planas inclinadas como jarillones (27%) y algunos nidos localizados cercanos a estructuras construidas por el hombre. El área de los nidos varió entre 1 y 211 m2. Se encontró una correlación positiva entre el número de cuadrantes que permitieron conocer el 50% de las bocas y el área del nido (r= 0, 70). Basados en esta metodología, es posible realizar una estimación rápida y confiable del grado de infestación de las áreas afectadas por la hormiga arriera, como medida previa para su manejo o control.

We studied the effects of commercial humic substances derived from leonardite at different rates (0, 0.25, 2, 10 g kg−1) and pH (4.5, 6.0, 8.0) on Cu and Zn mobility, to evaluate their use for remediation of metal contaminated mine soils and to optimize their application conditions. We conducted a single-step extraction experiment and analyzed extracts for metal concentrations, soluble organic carbon and their E4/E6 ratio (ratio of absorption at 465 to 665 nm). Metal speciation in a soil solution was simulated by the non-ideal competitive adsorption-Donnan (NICA-Donnan) model. Increasing the amount of humic substances and the pH caused higher release rates of soluble organic carbon with a lower humic/fulvic acids ratio. This led to a higher mobility of metals (up to 110 times Cu concentration in control and 12 times for Zn) due to the formation of soluble metal-humic complexes. Speciation modeling predicted that increasing rates of humic substances would result in a higher proportion of Cu and Zn associated with fulvic acids, more mobile than the humic acids fraction. Application of commercial leonardite humic substances at 2–10 g kg−1 and with pH levels similar to or below natural soil could be useful for assisted-phytoextraction of contaminated anthropogenic soils. High rates of humic substances in more alkaline conditions could entail a considerable risk of metal leaching to groundwater, toxicity and transfer to the trophic chain.

Abstract OBJECTIVE Tentorial dural arteriovenous malformations (DAVMs) are uncommon lesions associated with an aggressive natural history. Controversy exists regarding their optimal treatment. We present a single-institution series of tentorial DAVMs treated during a 12-year period, address the current controversies, and present the rationale for our current therapeutic strategy. METHODS Twenty-two patients with tentorial DAVMs were treated between 1988 and 2000. Treatment consisted of transarterial or transvenous embolization, surgical resection, disconnection of venous drainage, or a combination of these therapies. The clinical presentations, radiological features, treatment strategies, and results were studied. RESULTS Eighteen patients (82%) presented with intracranial hemorrhage or progressive neurological deficits. Retrograde leptomeningeal venous drainage was documented in 22 cases (100%), classifying the lesions as Borden Type III. Angiographic follow-up monitoring was performed for 0 to 120 months and clinical follow-up monitoring for 1 to 120 months. Posttreatment angiography demonstrated obliteration in 22 cases (100%). Two patients experienced neurological decline after endovascular treatment and died. All of the 20 surviving patients exhibited clinical improvement; there were no episodes of rehemorrhage or new neurological deficits. Outcomes were excellent in 17 cases (77%), good in 2 cases (9%), and fair in 1 case (5%), and there were 2 deaths (9%). CONCLUSION Tentorial DAVMs are aggressive lesions that require prompt total angiographic obliteration. Disconnection of the venous drainage from the fistula may be accomplished with transarterial embolization to the venous side, transvenous embolization, or surgical disconnection of the fistula. We think that extensive nidal resections carry more risk and are unnecessary. We do not think there is a role for stereotactic radiosurgery in the treatment of these lesions.

La playa de La Cuevita, con una extensión de 8 km, localizada en el corregimiento del Valle, municipio de Bahía Solano, Chocó, es una de las principales playas de anidación de Lepidocheys olivacea identificadas en el Pacífico colombiano. Durante la estación reproductiva de 1998 (de agosto a diciembre) registramos 113 arribos y trasladamos a un corral de protección (tortugario) 91 nidos con un total de 8.918 huevos. Las hembras presentaron una tendencia significativa a anidar en el primer sector de esta playa (kms 0-2) y en la zona de lavado. No encontramos un pico aparente de anidación durante la temporada reproductiva. El éxito de eclosión para los primeros 59 nidos trasladados fue 81.5% y el éxito reproductivo fue 79%. Monitoreamos la temperatura de incubación de diez de estos nidos hasta la fecha de eclosión de los mismos. Tanto la temperatura promedio de incubación a lo largo de todo el periodo de incubación, como el promedio de la temperatura únicamente durante el periodo crítico de incubación, mostraron fluctuaciones diarias por encima y por debajo de la temperatura umbral reportada para la población de tortuga golfina anidante en Playa Nancite, Costa Rica. Inspeccionamos histológicamente las gónadas de una muestra aleatoria de diez juveniles de diez nidos con registro de temperatura (n =100). En aquellos expuestos a temperaturas promedio menores de 29 ºC únicamente obtuvimos machos. Encontramos un porcentaje de hembras entre 40 y 70 bajo temperaturas de incubación entre 30 y 31 ºC. Se presentó un nido atípico con temperatura promedio de incubación de 30.5 ºC presentó una proporción sexual de 1:1. Se discute la necesidad de estimar la proporción sexual de los neonatos que eclosionan de nidos naturales en esta playa. De acuerdo con estos resultados, la forma en que se han manipulado los nidos y las actuales condiciones de incubación en el tortugario probablemente han favorecido la producción de machos durante años en una proporción de por lo menos 3:1, lo cual puede ir en detrimento del mantenimiento de esta población. Igualmente ¡, se sugiere que en futuros estudios en esta playa se determine la temperatura umbral para esta población con el fin de que si es necesario incubar los nidos artificialmente en el tortugario, como consecuencia de la elevada tasa de depredación de los nidos naturales en esta playa, se haga bajo condiciones muy similares a las naturales, para minimizar otras posibles alteraciones biológicas.

Neste trabalho, foi realizada a sÌntese e caracterizaÁ„o de membranas modificadas, a fim de que estas se tornem condutivas e capazes de oxidar matÈria org‚nica, alÈm de atuarem como barreira fÌsica de filtraÁ„o. Diferentes concentraÁıes de Polianilina (Pani) foram incorporadas mecanicamente a uma soluÁ„o base de PoliÈtersulfona (PES), 18% em massa em N-metil-2-pirrolidona, com a adiÁ„o de concentraÁıes de 2, 5, 10 e 15% em massa de PANI, com base na massa de PES. O mÈtodo de sÌntese utilizado foi o de invers„o de fases por imers„o, utilizando-se ·gua desmineralizada como n„o solvente. A caracterizaÁ„o das membranas foi feita com base nos ensaios de permeabilidade, porosidade e condutividade elÈtrica. As membranas modificadas, com a adiÁ„o de PANI, apresentaram um fluxo de permeado mais elevado do que a membrana de controle (0% Pani), sendo que os valores m·ximos foram encontrados para a membrana de 15% est„o em torno de 1430 L.h-1.m-2. Em contrapartida, a porosidade das membranas com adiÁ„o de 15% de PANI (65%), foi menor do que a obtida para a membrana de controle (90%). Para a avaliaÁ„o de condutividade elÈtrica foi utilizado um ohmÌmetro para mediÁ„o da resistÍncia elÈtrica de materiais pouco condutores. Com base nos resultados obtidos foi verificado que a condutividade elÈtrica das membranas aumentou com o aumento da concentraÁ„o de PANI. O valor m·ximo de condutividade encontrado foi de 9x10-7 Siemens (S). Para uma melhor compreens„o do efeito da utilizaÁ„o de PANI nas membranas modificadas s„o necess·rias an·lises adicionais. Para a prÛxima etapa do projeto est„o previstas an·lises de caracterizaÁ„o morfolÛgica da membranas por meio de microscopia eletrÙnica de varredura, medida do ‚ngulo de contato (hidrofilicidade), tamanho e distribuiÁ„o de poros, massa molecular de corte e ensaios especÌficos de oxidaÁ„o eletroquÌmica.

Background. Reduced-intensity conditioning (RIC) regimens are commonly used for hematopoietic cell transplantation (HCT) in non-malignant disorders to minimize potential drug-related toxicity from myeloablative conditioning (MAC). However, melphalan-based RIC regimens are associated with poor engraftment and need for second HCT or donor lymphocyte infusions (DLIs). This study expands on our previous experience with targeted busulfan, fludarabine, and intravenous (IV) alemtuzumab as a low-toxicity but myeloablative regimen to achieve sustained donor engraftment. Methods. We conducted a retrospective analysis of patients ≤25 years of age with non-malignant disorders who received targeted busulfan, fludarabine and IV alemtuzumab as conditioning for their first HCT between 2004 and 2018. Graft-versus-host disease (GVHD) prophylaxis included calcineurin inhibitors in all patients, plus methotrexate (n=59), methylprednisolone (n=2), or mycophenolate (n=1). The primary end point was 3-year overall survival (OS). Secondary end points included treatment-related mortality (TRM), event-free survival (EFS) defined as alive without second HCT or disease progression, and incidence of acute and chronic GVHD (aGVHD and cGVHD). Other end points included incidence of graft failure (GF) defined as <5% donor chimerism in whole blood, sinusoidal obstruction syndrome (SOS) and CMV viremia. Analysis was stratified by era of HCT (2004-2011 vs. 2012-2018). Results. We identified 62 patients with a median age of 5.5 years and male:female of 46:16. Diagnoses included primary immune deficiencies (60%), hemoglobinopathies (22%), bone marrow failure disorders (8%) and inherited metabolic disorders (10%). The median busulfan cumulative area-under-the-curve (cAUC) was 70 mg*h/L (range, 57-108 mg*h/L). Donors were matched sibling (MSD) in 27%, 8/8 allele-matched unrelated (MUD) in 50% and Class I allele-mismatched (MM) in 23%. All but 2 of the Class I allele-MM donors were unrelated. The source was bone marrow (BM) in 74% and peripheral blood stem cells (PBSC) in 26%. The cumulative incidence (CI) of GF was 8% (95% CI, 1-16%). In engrafted patients, the median donor chimerism in whole blood, CD3, CD14/15, and CD19 at 1-year was 96%, 90%, 99%, and 99%, respectively. Only 1 patient required DLIs for poor chimerism. T-cell reconstitution (CD4 >200 x 109/L and PHA response >50% control) was achieved at a median of 182 days (range, 76-585 days). Two patients died following disease progression despite 100% donor chimerism. The CI of TRM was 10% (95% CI, 2-17%). Causes of TRM included infectious complications (n=2), hemorrhage (n=1), respiratory failure (n=3 with 2 following subsequent transplants after graft rejection). TRM incidence was significantly higher in patients with Class I MM compared to those with MSD or 8/8 allele-MUD (29% vs 6% vs 3%; p=0.024; Figure 1A). SOS occurred in 5% of patients and all resolved with supportive therapy (n=1) or defibrotide (n=2). Post-transplant CMV viremia occurred in 26% of all patients and in 71% of CMV seropositive patients. None developed CMV disease and all infections resolved with anti-viral therapy. OS and EFS at 3-years were 87% (95% CI, 78-95%) and 80% (95% CI, 70-90%), respectively. HCTs performed in the more recent era showed an OS of 97% compared to 79% in HCTs performed earlier (p=0.057; Figure 1B). OS was 97% in patients with 8/8 allele-MUD compared to 79% in those with MSD and 71% in those with Class I allele-MM (p=0.051). The 6-month CI of grade II-IV aGVHD was 7% (95% CI, 3-13%), while the 3-year CI of cGVHD was 5% (95% CI, 0-11%). GVHD incidence was higher in patients receiving PBSC compared to BM (25% vs 0%; p<0.001) and in patients ≥5 years of age compared to those <5 years of age (13% vs 0%; p=0.043). Patients with inherited metabolic disorders showed significantly worse OS (44%, p=0.016), EFS (33%, p=0.001) and aGVHD (33%, p=0.008) than those in other disease groups. Univariate analysis did not show any significant differences in survival or GVHD incidence by race or sex. Conclusions. Use of targeted busulfan, fludarabine and IV alemtuzumab as myeloablative conditioning in pediatric patients with primary immunodeficiencies, hemoglobinopathies, and bone marrow failure syndromes undergoing matched sibling or well-matched unrelated donor HCT provides a well-tolerated option to achieve sustained engraftment with low incidence of GVHD and toxicities such as SOS. Figure 1 Disclosures Shimano: Pfizer: Research Funding; Daiichi Sankyo: Research Funding; Novartis: Research Funding. Huang:Novartis: Research Funding. Cowan:Homology Medicine: Equity Ownership, Membership on an entity's Board of Directors or advisory committees; Leadiant: Consultancy; California Institute Of Regenerative Medicine: Research Funding; NIH NIAD: Research Funding; Rocket Pharma: Consultancy; UpToDate: Honoraria; bluebird bio: Consultancy. Dvorak:Alexion Inc: Consultancy; Jazz Pharmaceuticals: Consultancy.

Successful hematopoietic cell transplantation (HCT) requires vacating recipient hematopoietic stem cell (HSC) niches to permit transplanted HSC to engraft. Currently, DNA damaging radiation or chemotherapy are used to eliminate recipient HSC and achieve niche clearance. We have pursued a non-genotoxic approach to target and deplete HSC using a humanized monoclonal antibody, AMG 191, that binds human CD117 (c-Kit), a receptor tyrosine kinase expressed on the surface of HSC and progenitor cells (HSPC). We have shown that AMG 191 suppresses human hematopoiesis in vitro, depletes human HSC in mice xenografted with human cells, and safely depletes HSC of non-human primates. We have initiated a Phase I dose escalation trial to test AMG 191 as the sole conditioning agent to achieve donor CD34-enriched HSPC engraftment in patients undergoing HCT for severe combined immunodeficiency (SCID) (ClinicalTrials.gov: NCT02963064). SCID is a severe genetic immune disorder curable only by HCT. Because of toxicity concerns, infants with SCID often receive donor hematopoietic grafts without conditioning, resulting in a lack of donor HSC engraftment. Instead, mature T lymphocytes and possibly lymphoid progenitors engraft but support only donor T cell development. This approach is associated with incomplete and poorly sustained immune reconstitution, and many patients have either no donor B cells and/or poor B cell function requiring life-long immunoglobulin replacement therapy. Second unconditioned donor HSC "boosts" can be performed, but they do not result in HSC engraftment and immune defects may persist. The primary endpoint of our study is to assess the safety and tolerability of AMG 191 as a conditioning agent in SCID patients. Secondary endpoints include AMG 191 pharmacokinetics (PK), host HSC depletion, and the determination of the dose of AMG 191 that achieves adequate donor HSC engraftment, defined as &gt;5% donor blood granulocyte chimerism in peripheral blood at 24 weeks. Seven patients have been treated to date who are &gt;12 weeks post-HCT (Table 1): three in each of the first two dose cohorts (0.1 and 0.3 mg/kg AMG 191), and one patient in the third cohort (1.0 mg/kg). An eighth patient has been treated at the 1.0 mg/kg dose and is three weeks post-HCT. Patients have a mixture of SCID genotypes. All patients treated to date had prior HCT with lack of donor HSC engraftment as evidenced by 0% donor sorted granulocyte chimerism at study entry. AMG 191 administration and infusion of original donor CD34+-selected cells were uniformly well tolerated. Pre- and post-infusion marrow analyses in five evaluable patients demonstrated dose-dependent decline in CD117+HSPC following AMG 191 treatment. Table 1 shows that four of six patients, who are &gt;24 weeks post-HCT, reached the predefined endpoint of &gt;5% granulocyte chimerism at 24 weeks, demonstrating donor HSC engraftment. The two patients who did not show donor engraftment at 24 weeks had detectable, low level (&lt;5%) engraftment at later time points. All patients with follow up of &gt;36 weeks show the production of recent thymic emigrants and/or de novo production of naïve T and/or B cells. In addition to improved lymphocyte values, patients have demonstrated clinical improvement including resolution of chronic diarrhea, significant weight gain, and reduced IVIG requirements. Conclusion: This study is the first demonstration of HSC engraftment following monoclonal antibody-based conditioning of patients without chemo(radio)therapy. Specifically, this first-in-human HCT trial shows that an anti-CD117 antibody safely clears HSC niches and facilitates donor HSPC engraftment in patients with SCID. Clinical benefit has been observed with minimal to no toxicity. Four of six evaluable patients have sustained evidence of donor myeloid engraftment along with T and B lymphopoiesis, indicative of engraftment of multipotent HSC. These results suggest that antibody conditioning for HCT may be preferable to traditional chemo(radio)therapy conditioning, especially in patients with non-malignant diseases and/or increased risk of toxicities due to such agents, such as certain forms of SCID, Fanconi anemia and sickle cell disease. Anti-CD117 antibody conditioning may also be applicable to gene therapy with genetically corrected autologous HSC. The AMG 191 study is actively enrolling previously transplanted SCID patients and newly diagnosed SCID patients. Disclosures Dvorak: Alexion Inc: Consultancy; Jazz Pharmaceuticals: Consultancy. Prohaska:Forty Seven Inc: Equity Ownership, Patents & Royalties. Weissman:Forty Seven Inc.: Consultancy, Equity Ownership, Patents & Royalties. Cowan:Rocket Pharma: Consultancy; Homology Medicine: Equity Ownership, Membership on an entity's Board of Directors or advisory committees; bluebird bio: Consultancy; California Institute Of Regenerative Medicine: Research Funding; UpToDate: Honoraria; Leadiant: Consultancy; NIH NIAD: Research Funding. Logan:Kadmon: Research Funding; Amgen: Consultancy, Membership on an entity's Board of Directors or advisory committees; Kite: Research Funding; TeneoBio: Consultancy; Novartis: Consultancy; Astellas: Research Funding; Abbvie: Consultancy; Incyte: Membership on an entity's Board of Directors or advisory committees; Pharmacyclics: Research Funding; Kiadis: Consultancy; Jazz: Research Funding; Agios: Consultancy, Membership on an entity's Board of Directors or advisory committees. Weinberg:U.S. Patent Office: Patents & Royalties: patent pending - submitted for aldehyde dehydrogenase 2 (ALDH2) activators to expand hematopoietic stem cells. Shizuru:Forty Seven Inc: Equity Ownership, Patents & Royalties.

Background and purpose To investigate Susceptibility Weighted Imaging (SWI) signal changes in the draining vein of deep-seated arterio-venous malformations (AVMs) following stereotactic radiosurgery (SRS). Methods and Materials This is a retrospective study of 32 patients with deep-seated AVMs who were treated with SRS. Pre-SRS treatment and post-SRS treatment MRI were performed at 6, 12, and 24-month intervals. Deep-seated AVMs were classified based on their anatomical location and venous drainage pattern. AVM nidal volume (cm3) was estimated using the ABC/2 method. AV shunting of the AVM draining veins were graded according to its SWI signal intensity: hyperintense (grade III), mixed signal intensity (grade II), hypointense (grade I) and absent (grade 0). Conventional time-of-flight (TOF)-MRA and contrast enhanced (CE)-MRA sequences were performed to document the patency of the vein. Results Pre-SRS treatment AVM draining veins were either grade III 18/32 (56%) or grade II 14/32 (44%). Using mixed effects analysis, we demonstrate that each month following the SRS treatment nidal volumes decreased at the rate of 0.51 cm3/per month (CI −0.61 to (−0.40)) p =.00. Following the treatment, there was a clinically significant relationship between the signal and nidal volume: signal 0 corresponded with average nidal volume of 1.81 cm3 (CI 1.40–2.21), signal 1 with nidal volume of 2.06 cm3 (CI 1.69–2.44), signal 2 with nidal volume 2.73 cm3 (CI 2.35–3.11) and signal 3 with nidal volume 3.13 cm3 (CI 2.70–3.56) p = .00. Conclusion Post-SRS AVM draining veins shows a stepwise regression of the SWI signal grades which can be reliably used as a surrogate to monitor the reduction of AV shunting.

: 0 PRESENTE TRABALHO APRESENTA UM PERFIL DA EDUCAÇÃO FÍSICA Curricular na Universidade'Federal do Rio Grande do Sul, a partirDA VISÃO DISCENTE. OlTOCENTOS E TRINTA E DOIS UNIVERSITÁRIOS, REGU­LARMENTE MATRICULADOS, RESPONDERAM A UM QUESTIONÁRIO COM QUARENTA E DOIS ITENS DIVIDIDOS EM TRÊS PARTES! 1- OBJETIVOS ATINGIDOS PELA PrÁtica Desportiva; 2- aspectos dificultadores do processo ensino-apren dizagem; 3- aspectos gerenciais. Concluiu-se que a Prática DesportiVA, NA UFRGS, APRESENTA COMO PRINCIPAL ÓBICE a FALTA DE_UM ADEQUADO DIMENSIONAMENTO FILOSÓFICO SOBRE 0 REAL PAPEL DA EdUCAÇAO FÍSICA NO y- GRAU. Com ISSO, A PDU, SE TORNA UMA ATIVIDADE EMINENTEMENTE MECA NICA, ONDE A SIMPLES PRATICA DE UMA ATIVIDADE FÍSICA CONSTITUI SEU MAIOR OBJETIVO.

Purpose: High-resolution vessel wall magnetic resonance imaging (VW-MRI) could provide a way to identify high risk arteriovenous malformation (AVM) features. We present the first pilot study of clinically unruptured AVMs evaluated by high-resolution VW-MRI.Methods: A retrospective review of clinically unruptured AVMs with VW-MRI between January 1, 2016 and December 31, 2018 was performed documenting the presence or absence of vessel wall “hyperintensity,” or enhancement, within the nidus as well as perivascular enhancement and evidence of old hemorrhage (EOOH). The extent of nidal vessel wall “hyperintensity” was approximated into five groups: 0, 1–25, 26–50, 51–75, and 76–100%.Results: Of the nine cases, eight demonstrated at least some degree of vessel wall nidus “hyperintensity.” Of those eight cases, four demonstrated greater than 50% of the nidus with hyperintensity at the vessel wall, and three cases had perivascular enhancement adjacent to nidal vessels. Although none of the subjects had prior clinical hemorrhage/AVM rupture, of the six patients with available susceptibility weighted imaging to assess for remote hemorrhage, only two had subtle siderosis to suggest prior sub-clinical bleeds.Conclusion: Vessel wall “enhancement” occurs in AVMs with no prior clinical rupture. Additional studies are needed to further investigate the implication of these findings.

Introduction : Dual‐lumen balloon catheters (DLBCs) are used routinely in the endovascular treatment of cerebral vascular malformations and reportedly, they have been noted to present significant advantages compared to single‐lumen catheters (SLCs). We conducted a systematic review and a pooled analysis in order to assess DLBCs’ overall safety and efficacy and complication rates. Methods : In this PROSPERO registered, PRISMA compliant systematic review, we sought to identify all MEDLINE and EMBASE published single‐arm (DLBCs) and double‐arm (DLBCs versus SLCs) cohorts where DLBCs were used for the treatment of cerebral arteriovenous malformations (AVMs) and dural arteriovenous fistulas (dAVFs). A pooled analysis was conducted for the included single‐arm studies. Immediate angiographic outcome, complications related to the catheter, reflux episodes and entrapment were the primary outcomes, summarized in the pooled analysis. Secondary outcomes included mortality and reported navigability. A meta‐analysis of the double‐arm studies summarized the primary outcomes of total procedural time and immediate angiographic outcome. Registration‐URL: https://www.crd.york.ac.uk/prospero/ Unique Identifier: CRD42021269096 Results : Of the 298 records that were screened by title and abstract, 24 underwent full‐text review. Ultimately, 19 studies were included and combined into a pooled analysis. Of the 227 lesions that were treated, complete (100%) nidal occlusion was achieved in 171 (75%; 95% CI: [69.1‐80.7%]), near‐complete (90‐99%) in 18 (8%; [4.9‐12.4%]), partial/incomplete (25‐89%) in 36 (16%; [11.5‐21.4%]) and none (<25%) in 2 (1%; [0.2‐3.5%]). In total, 13 complications related to the catheter were reported (5.73%; [3.2‐9.8%]), 14 reflux events (6%; [1.9‐10.4%]), 2 entrapment events (1%; [0.2‐3.5%]) and 0 deaths (mortality rate 0%; [0‐2.1%]). Based on two independent reviewers, the navigability of the catheter was judged to be reported as “very good” in 4 studies, “subjectively good” in 9, “slightly more difficult than SLCs” in 5 and “significantly more difficult than SLCs” in 1 study. Of the 19 included studies, only two were double‐armed and combined into a meta‐analysis. The mean total procedural time (SD) was 64.9 minutes (37.5) for DLBCs compared to 125.7 (81.8) for SLCs (P<0.0001), while complete nidal occlusion was noted in 39/45 (86.7%; [72.5‐94.5%]) with the DLBCs compared to 17/29 (58.6%; [39.1‐75.9%]) with the SLCs (P = 0.00596), when only dAVFs where combined. The mean total procedural time was 65.5 minutes (39.1) for DLBCs compared to 106.2 (78.3) for SLCs (P = 0.001), while complete nidal occlusion was noted in 46/59 (78%; [65‐87.3%]) with the DLBCs compared to 52/69 (75.3%; [63.3‐84.6%]) with the SLCs (P = 0.726), when both AVMs and dAVFs where combined. Conclusions : DLBCs are safe and effective for the embolization of cerebral AVMs and dAFVs. More importantly, they can achieve faster and potentially superior results compared to SLCs, when used in the appropriate context. A lack of well‐designed controlled comparative studies has been identified in the literature.

Abstract Background Since the introduction of sentinel node biopsy (SLNB) in unifocal vulvar cancer (diameter of < 4 cm) and unsuspicious groin lymph nodes, the morbidity rate of patients has significantly decreased globally. In contrast to SLNB, bilateral inguinofemoral lymphadenectomy (IFL) has been associated with increased risk of common morbidities. Current guidelines (NCCN, ESGO, RCOG, and German) recommend that in cases of unilaterally positive sentinel lymph node (SLN), bilateral IFL should be performed. However, two recent publications by Woelber et al. and Nica et al. contradict the current guideline, since a significant rate of positive non sentinel lymph nodes in IFL contralaterally was not observed [Woelber et al. 0% (p = 0/28) and Nica et al. 5.3% (p = 1/19)]. Methods A retrospective single-center analysis conducted in the University Hospital of Dusseldorf, evaluating vulvar cancer patients treated with SLNB from 2002 to 2018. Results 22.2% of women (n = 4/18) were found to have contralateral IFL groin metastasis after an initial diagnosis of unilateral SLN metastasis. The depth of tumor infiltrating cells correlated significantly and positively with the rate of incidence of groin metastasis (p = 0.0038). Conclusion Current guideline for bilateral IFL should remain as the standard management. Therefore, this depth may be taken into account as an indication for bilateral IFL. The management of VC and SLNB should be performed in a high volume center with an experienced team in marking SLN and performing the adequate surgical procedure. Well conducted counseling of the patients outlining advantages but also potential oncological risks of this technique especially concerning rate of groin recurrence is critical.

Background and Purpose: Patients with higher Spetzler-Martin grade cerebral arteriovenous malformations (AVMs) are associated with poorer neurologic and clinical outcomes. Four dimensional computed tomography angiography (4D-CTA) is newly and promising technique in the diagnosis of patients with cerebral arteriovenous malformations (AVMs). The purpose of this retrospective study was to investigate the utility of 4D-CTA using whole-brain 320- detector row CT for assessing cerebral AVMs compared with conventional angiography (CA). Materials & Methods: Participants comprised patients admitted to our institution from November 2010 to March 2012 due to cerebral AVMs, who underwent both 4D-CTA and CA within 14days. The diagnosis of AVM was finally confirmed by CA. Two readers reviewed 4D-CTA and CA under consensus regarding detection rate of the AVMs, each component of the AVMs (feeders, nidi, drainers) which was scored using four-point grading scale (excellent=3, good=2, fair=1, poor=0), and the Spetzler-Martin (S-M) grade. Results: During study periods, eleven patients met our criteria. In every case, cerebral AVM was diagnosed by 4D-CTA. The average score for feeders, nidi, and drainers was 2.0, 2.3, and 2.5 in 4D-CTA and 2.4, 2.6, and 2.7 in CA, respectively. The average score of S-M grade was both 2.0, and matched in 11/11 patients. There were no significant differences statistically between two modalities (P<.005). Conclusion: 4D-CTA using 320-detector row CT is a very reliable method and offered diagnostic performance equivalent to CA in detecting and predicting S-M classification of cerebral AVMs.

Precipitating hydrophobic injectable liquid (PHIL; MicroVention, Aliso Viejo, CA, USA) and Squid (Balt, Irvine, CA, USA) are 2 newer liquid embolic agents used in endovascular embolization of cerebral arteriovenous malformation (AVM). This study aims to investigate and compare the effectiveness and safety profile of the 2 newer liquid embolic agents in the embolization of cerebral AVM. This is a retrospective study on all patients diagnosed with cerebral AVM undergoing endovascular embolization with liquid embolic agents PHIL and Squid admitted to the Division of Neurosurgery, Department of Surgery in Prince of Wales Hospital from January 2014 to June 2021. Twenty-three patients with cerebral AVM were treated with 34 sessions of endovascular embolization with either PHIL or Squid (17 sessions each) liquid embolic agents with a male to female ratio of 2.3:1 (male 16; female 7) and mean age of 44.6 (range, 12 to 67). The mean total nidus obliteration rate per session was 57% (range, 5% to 100%). Twenty-one patients (91.3%) received further embolization, stereotactic radiosurgery, or surgical excision after initial endovascular embolization. There were 2 morbidities (1 neurological and 1 non-neurological, 6%) and no mortalities (0%). All patients had static or improvement in modified Rankin Scale at 3 to 6 months at discharge. PHIL and Squid are effective and safe liquid embolic agents for endovascular embolization of cerebral AVM, achieving satisfactory nidal obliteration rates and patient functional outcomes.

AbstractFloodplain soilscapes act as temporary sinks in the environment and are nowadays affected by multiple contaminant accumulations and exposures, including different trace metals and plastics. Despite increasing knowledge about the occurrence and behaviour of plastics at the interface between aquatic and terrestrial systems, there are still major uncertainties about the spatial distribution of plastics, their sources and deposition, as well as spatial relationships with other contaminants. Our recent case study addresses these questions, using the example of a river system ranging from rural to urban areas. Based on a geospatial sampling approach we obtained data about soil properties, metal contents via ICP-MS analyses, and particle-based (171 μm – 52 mm) plastic contents, analysed using sodium chloride density separation, visual fluorescence identification and ATR-FTIR analysis. We found plastic contents of 0.00–35.82 p kg− 1 and zero to moderate metal enrichments. Levels of both contaminations occur in the lower range of known concentrations in floodplain soils and show a different spatial distribution along the river course and in the floodplain cross-section. Furthermore, we found that plastic enrichment occurs in the uppermost soil layers, while trace metal enrichment is equally distributed over depth, indicating different sources like flood dynamics and agricultural practice during different deposition periods. Finally, direct short to long-term anthropogenic impacts, like floodplain restoration or tillage may affect plastic enrichments, raising questions for future research directions within floodplain soilscapes.

ObjectiveWe seek to integrate multiple streams of geo-coded information withthe aim to improve public health surveillance accuracy and efficiency.Specifically for vector-borne diseases, knowledge of spatial andtemporal patterns of vector distribution can help early prediction ofhuman incidence. To this end, we develop joint modeling approachesto evaluate the contribution of vector or reservoir information on earlyprediction of human cases. A case study of spatiotemporal modelingof tularemia human incidence and rodent population data from Finnishhealth care districts during the period 1995-2013 is provided. Resultssuggest that spatial and temporal information of rodent abundance isuseful in predicting human cases.IntroductionAn increasing number of geo-coded information streams areavailable with possible use in disease surveillance applications.In this setting, multivariate modeling of health and non-health dataallows assessment of concurrent patterns among data streams andconditioning on one another. Therefore it is appropriate to considerthe analysis of their spatial distributions together. Specifically forvector-borne diseases, knowledge of spatial and temporal patternsof vector distribution could inform incidence in humans. Tularemiais an infectious disease endemic in North America and parts ofEurope. In Finland tularemia is typically mosquito-transmitted withrodents serving as a host; however a country-wide understanding ofthe relationship between rodents and the disease in humans is stilllacking. We propose a methodology to help understand the associationbetween human tularemia incidence and rodent population levels.MethodsData on rodent population levels are collected around the countryby the Finnish Natural Resources Institute. Human Tularaemia casesare recorded as laboratory-confirmed and reported to the NationalInfectious Disease Register (NIDR). Human cases and rodent datawere aggregated to match the 20 Finnish health districts over the period1995-2013 [1]. We develop our methodology in a Bayesian setting.The counts of human cases for each health district in a given yearare assumed to follow a Poisson distribution and the rodent data areassumed to have a categorical likelihood. The linear predictors linkedto the human and rodent likelihood functions are then decomposedadditively into spatial, temporal, and space-time interaction randomeffects. We then link the two likelihoods via the interaction term byassuming that the human spatiotemporal variation is dependent on therodent activity with one-year lag. In the case of the rodent data, wealso included two additional spatial and non-spatial contextual termsto better model ecological effects associated with rodent populationlevels as described before [2]. We then finally develop indicators, onthe scale 0 to 1, to quantify the association between human incidenceand a rodent vector.ResultsResults suggest that spatial and temporal information of rodentabundance is useful in predicting human cases.ConclusionsFuture modeling directions are recommended to includeenvironmental and epidemiological factors. To the best of ourknowledge, this is the first time that rodent data, captured for non-health related purposes, is used to better inform the human risk oftularemia in Finland.