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Thèses sur le sujet « NFE2 »

Auteur : Grafiati

Publié le 9 mars 2023

Mis à jour le 31 juillet 2025

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1

AMARU, CALZADA ARIEL. "Mechanism of action of Histone Deacetylase inhibitor. Givinostat in Chronic Myeloproliferative neplasm." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2013. http://hdl.handle.net/10281/44363.

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We investigated the mechanism of action of the histone deacetylase inhibitor Givinostat (GVS) in Janus kinase 2 (JAK2)V617F myeloproliferative neoplasm (MPN) cells. GVS inhibited colony formation and proliferation and induced apoptosis at doses two- to threefold lower in a panel of JAK2V617F MPN compared to JAK2 wild- type myeloid leukemia cell lines. By global gene expression analysis, we observed that GVS modulated 293 common genes in the JAK2V617F cell lines HEL and UKE1. In particular, the hematopoietic transcription factors NF-E2 and C-MYB were downmodulated by the drug specifically in JA

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2

Ellingsen, Rikke. "Nonlinear Isogeometric Analysis vs NFEA of Tubular Joints." Thesis, Norges teknisk-naturvitenskapelige universitet, Institutt for konstruksjonsteknikk, 2013. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-21878.

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In 2005, Hughes et al. introduced the isogeometric analysis. One purpose was to eliminate the conversion between geometry model and analysis model in finite element analyses. NURBS (Non-Uniform Rational B-Splines) were adopted as shape functions and the isoparametric concept was utilized, resulting in the above mentioned analysis method.In this thesis, the differences between traditional finite element analysis and isogeometric analysis have been examined through nonlinear analyses of a gap K-joint subjected to prescribed displacements. The K-joint has been modelled both with solid and thin sh

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Dahmani, Younes. "Uttryck av Nfr2 och dess kliniska roll i klarcellig njurcancer." Thesis, Umeå universitet, Biomedicinsk laboratorievetenskap, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-58605.

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Chesney, James R., Nicholas J. Speciale, and Anil K. Agrawal. "Design of the TOPEX-NFEP Utilizing the Functional Component Approach." International Foundation for Telemetering, 1989. http://hdl.handle.net/10150/614728.

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International Telemetering Conference Proceedings / October 30-November 02, 1989 / Town & Country Hotel & Convention Center, San Diego, California<br>TOPEX/POSEIDON is a joint American/French Ocean Topography Experiment undertaken by the National Aeronautics and Space Administration (NASA) and Center National d'Etudes Spatiales (CNES) to acquire, process and verify altimetric sea surface height data so that mean and variable geotropic surface currents of the world's oceans can be mapped. This paper describes the functions and the architecture of the proposed front end to the Telemetry, Command

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Bruder, Carl E. G. "Genetic analysis of neurofibromatosis type 2 (NF2) patients and NF2-associated tumors with emphasis on chromosome 22 deletions /." Stockholm, 2000. http://diss.kib.ki.se/2000/91-628-4370-2/.

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Vahldiek, Kai-Felix. "Allelverluste bei Neurofibromatose Typ 2 (NF2) assoziierten Meningeomen." [S.l.] : [s.n.], 2001. http://deposit.ddb.de/cgi-bin/dokserv?idn=965649512.

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Klungsupya, P. "Nucleotide excision repair of the plasmid borne NFA2 gene in Saccharomyces cerevisiae." Thesis, Swansea University, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.637808.

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The role of transcription in repair of UV-induced CPD was investigated in the <I>Saccharomyces cerevisiae</I> <I>MFA2</I> gene. <I>MFA2</I> mutants were constructed for cloning into a yeast artificial chromosome (YAC) by deletion of either the 22nt TATA box sequences (T2Δ<I>MFA2</I>) or 55nt Mcm1 binding site (MΔ<I>MFA2</I>) from its promoter. <I>In vivo</I> transcription analysis using eGFP reporter system reveals a 10-fold reduction in transcription activity for the T2Δ<I>MFA2</I> a cells compared to the WT<I>MFA2 </I>a cells. This reduced transcription level is very close to the level found

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Vigorito, Christian. "Implementazione di algoritmi di stima della distanza con segnali a bassa frequenza." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2012. http://amslaurea.unibo.it/3534/.

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L’obiettivo di questo lavoro di tesi è stato quello di definire degli algoritmi in grado di comprendere le prestazioni raggiungibili dalla tecnica NFER alternativa in termini di ranging e accuratezza e, di conseguenza, dedurre se il sistema sia utilizzabile o meno.

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Schmid, M. C. "The role of focal adhesion kinase (FAK) in NF2 -/- turmourigenesis." Thesis, Exeter and Plymouth Peninsula Medical School, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.701076.

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Paganini, Irene. "Exploring the complexity of Schwannomatosis: the role of LZTR1 and the molecular framework of schwannomatosis-associated schwannomas." Doctoral thesis, Università di Siena, 2020. http://hdl.handle.net/11365/1096834.

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Schwannomatosis (SCH) predisposes to multiple schwannomas, caused by mutations in two genes on 22q: SMARCB1 and LZTR1. A 4-hit mechanism, involving SMARCB1, LZTR1 and NF2, brings to development of SCH-related tumors. SMARCB1 shows a clearly define role in schwannomatosis, with a peculiar association of specific mutations with the development of meningiomas. Frequency of LZTR1 mutations is about 50 and 30% in familial and sporadic cases, respectively and we demonstrated that the type of LZTR1 mutation is related to protein expression in SCH-associated tumors. However, the remarkable defect

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Johnson, Kristen C. (Kristen Carrie) 1976. "Analysis of the function of the Nf2 tumor suppressor protein, Merlin." Thesis, Massachusetts Institute of Technology, 2003. http://hdl.handle.net/1721.1/29763.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 2003.<br>Vita.<br>Includes bibliographical references.<br>The Neurofibromatosis type 2 tumor suppressor gene (NF2) is mutated in inherited and sporadically occurring central nervous system tumors. The NF2 encoded protein, merlin, shares close sequence similarity in its amino-terminal domain to members of the band 4.1 family of membrane-cytoskeletal linkers. Similarities between merlin and this family suggest a role for merlin in regulating cytoskeletal function. Thus, NF2 may be a novel type of tumor suppressor gene that

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Schulze, Karin Marlies Marion. "Herstellung rekombinanter Retroviren, In-vitro-Gentransfer und Expressionsanalyse des NF2-Gens Merlin." [S.l. : s.n.], 2001. http://deposit.ddb.de/cgi-bin/dokserv?idn=962345210.

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Flynn, Sara Jane. "A comparative and exploratory study of the Nfer-Nelson Emotional Literacy Scale in an Irish context." Thesis, University of Exeter, 2010. http://hdl.handle.net/10036/3041.

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Culturally specific development of Emotional Literacy (EL) skills suggest that self report and observer ratings on EL scales would differ across cultures. This study is the first of two which explores and compares the Nfer-Nelson Emotional Literacy scale (Faupel, 2003) scores reported in the manual with those found in an Irish sample with a view to demonstrating its appropriateness as a cross cultural measure of EL. The three part scale comprise student (N=188), teacher (N=163) and parent (N=175) scales. The scales were completed in schools with a disadvantaged (74% of sample) or non-disadvant

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Mason, Susan. "Investigating pathological mutations in the neurofibromatosis type 2 tumour suppressor gene." Thesis, University of Newcastle Upon Tyne, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.245083.

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Chen, Yaxiong. "Characterization of chicken NF2/merlin and its functions in early limb muscle development /." free to MU campus, to others for purchase, 2003. http://wwwlib.umi.com/cr/mo/fullcit?p3115532.

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Zhan, Yu. "Mixed Lineage Kinase 3 Signaling in Ovarian Cancer and Neurofibromatosis-2." University of Toledo / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1310127039.

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Thaxton, Courtney Lynn. "Mechanisms Promoting Phosphorylation of the NF2 Tumor Suppressor and its Effects on Schwann Cell Development." Doctoral diss., University of Central Florida, 2007. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/2154.

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Neurofibromatosis type 2 is an autosomal dominant disease characterized by the formation of schwannomas and other peripheral neuropathies. The nf2 gene encodes the protein Schwannomin, or merlin. Schwannomin (Sch) is a membrane-cytoskeletal linking protein that suppresses cell proliferation at high cell density and modulates cell shape. Sch's tumor suppressive activity is regulated by its localization, conformation, and phosphorylation at serine 518 (S518). Sch's localization is dependent on binding the scaffold protein, paxillin. Phosphorylation of Sch at S518 regulates its conformation and t

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Manent, Jan. "Analyse fonctionnelle du gène suppresseur de tumeur NF2 impliqué dans la Neurofibromatose de type 2." Paris 6, 2006. http://www.theses.fr/2006PA066296.

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DEGUEN, BRIGITTE. "Modeles cellulaires permettant l'etude fonctionnelle de la schwannomine, produit du gene suppresseur de tumeurs nf2." Paris 11, 1998. http://www.theses.fr/1998PA112158.

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La neurofibromatose de type 2 est une maladie a transmission autosomique dominante qui predispose a la survenue de schwannomes et de meningiomes. Le gene suppresseur de tumeurs nf2, dont les alterations constitutionnelles sont responsables de ce syndrome tumoral hereditaire, code une proteine, la schwannomine, homologue aux proteines erm impliquees dans l'ancrage du cytosquelette d'actine a la membrane plasmique. Afin d'initier l'etude fonctionnelle de la schwannomine, nous avons dans un premier temps genere des reactifs immunologiques specifiques de cette proteine. Par la suite, notre travail

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Mani, Timmy. "The Role of Phosphoinositide Binding in Merlin Function." University of Cincinnati / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1299181100.

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Adès, Noémie. "PAK1 and NF2 antagonist functions in regulating central nervous system myelination : from modulation of oligodendrocyte cytoskeleton to myelin sheath formation." Electronic Thesis or Diss., Sorbonne université, 2024. https://accesdistant.sorbonne-universite.fr/login?url=https://theses-intra.sorbonne-universite.fr/2024SORUS197.pdf.

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Dans le système nerveux central, la formation des gaines de myéline par les oligodendrocytes permet une propagation efficace et adaptée des potentiels d'action le long des axones, ainsi qu'un apport métabolique aux neurones. Le processus de myélinisation requière une fine régulation du cytosquelette d'actine des oligodendrocytes. En effet, la première étape de la myélinisation, qu'est l'extension d'un prolongement par les oligodendrocytes pour atteindre un axone, est soutenue par une polymérisation de l'actine. En revanche, l'enroulement de ce prolongement et son étalement autour de l'axone po

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Beltrami, Sarah. "NEUROFIBROMATOSIS TYPE 2 PROTEIN (NF2) AS A REGULATOR OF TUMOR SUPPRESSORS AND VIRAL ONCOPROTEINS IN HUMAN GLIOBLASTOMA." Diss., Temple University Libraries, 2014. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/239188.

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Biomedical Neuroscience<br>Ph.D.<br>Glioblastomas are the most common brain malignancy occurring in adults with the worst prognosis. Several obstacles have prevented the development of efficacious treatment strategies. Due to the insidious nature of these malignancies, tumors are not typically detected until late in the disease. Further, the delicate nature of surrounding normal brain tissue makes surgery and treatment with cytotoxic chemotherapeutics detrimental to the patient's quality of life. Despite decades of research and aggressive therapeutic strategies, most patients will develop recu

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Kukuyan, Anna-Mariya. "ROLE OF BAP1 IN MESOTHELIOMA AND MELANOMA PREDISPOSITION." Diss., Temple University Libraries, 2019. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/556760.

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Biomedical Sciences<br>Ph.D.<br>BAP1 (BRCA-Associated Protein1) is a tumor suppressor gene encoding a deubiquitinating enzyme (DUB) that regulates many facets of cellular biology. Genetic studies have demonstrated that somatic BAP1 mutations occur in numerous cancer types and that germline BAP1 mutations lead to a cancer susceptibility disorder that predisposes individuals to various tumors, in particular malignant mesothelioma (MM) and both uveal melanoma (UM) and cutaneous melanoma (CM). The Testa laboratory has identified several families (including one in Louisiana, designated Lou) with ge

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Worseck, Josephine Maria. "Characterization of phosphorylation-dependent interactions involving neurofibromin 2 (NF2, merlin) isoforms and the Parkinson protein 7 (PARK7, DJ1)." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2012. http://dx.doi.org/10.18452/16533.

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Veränderungen in phosphorylierungsabhängigen Signalwegen, Akkumulation von Proteinaggregaten im Gehirn und neuronaler Zelltod sind Neurodegenerationskennzeichen und Indikatoren für überlappende molekulare Mechanismen. Um Einblicke in die involvierten Signalwege zu erhalten, wurde mit Hilfe eines modifizierten Hefe-Zwei-Hybrid (Y2H)-Systems für 71 Proteine, die mit neurologischen Erkrankungen assoziiert sind, proteomweit nach Protein-Protein Interaktionen (PPIs) gesucht. Für 21 dieser Proteine wurden PPIs identifiziert. Das Gesamtnetzwerk besteht aus 79 Proteinen und 90 PPIs von denen 5 phospho

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Hamza, Kankia Ibrahim. "Design and development of novel tools for the screening and identification of inhibitors of HER receptor family and NFR2 for ovarian cancer therapy." Thesis, Abertay University, 2017. https://rke.abertay.ac.uk/en/studentTheses/441e2039-1bde-448b-9c87-d2845ac1da96.

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Cancer, which is characterised by aggressiveness and increased capacity for metastatic spread still requires basic researchers and clinicians to direct enormous efforts toward the development of novel therapeutic targets. Potential novel targets can be identified and exploited in combination with currently existing therapeutic approaches to improve their efficacy and overcome treatment resistance of tumour cells, protecting the patient from recurrence. To achieve this, different strategies and techniques can be proposed to identify the most promising candidate molecules for further exploitatio

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Sperka, Tobias [Verfasser]. "Ein neuer, regulierter Komplex des NF2-Tumorsuppressor-Genproduktes Merlin mit p190RhoGAP und p120RasGAP / Forschungszentrum Karlsruhe GmbH, Karlsruhe. Tobias Sperka." Karlsruhe : FZKA, 2006. http://d-nb.info/978199979/34.

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Peyre, Matthieu. "Modélisation de la tumorigenèse méningée chez la souris : progression tumorale liée à Nf2 et Cdkn2ab et voies alternatives d'oncogenèse." Paris 7, 2013. http://www.theses.fr/2013PA077109.

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Les méningiomes constituent la tumeur primitive la plus fréquente du système nerveux central. Bien que ces tumeurs soient majoritairement bénignes, elles peuvent récidiver après exérèse complète et conduire à une importante morbidité, et il existe une fraction croissante, jusqu'à 30%, de formes histologiquement agressives (OMS Grades II et III). La création de modèles souris génétiquement modifiés de méningiomes est un outil précieux dans la compréhension des mécanismes de tumorigenèse méningée et la réalisation d'essais pré-cliniques prédisant avec exactitude la réponse tumorale chez l'homme.

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Boin, Alizée. "Le rôle de la voie Hippo dans la fonction suppresseur de tumeur associée au gène NF2 et la régulation de Yap par Merlin dans les cellules de Schwann." Thesis, Paris 11, 2014. http://www.theses.fr/2014PA112282.

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Les schwannomes sont des tumeurs bénignes se développant à partir d’une hyper-prolifération des cellules de Schwann suite à l’inactivation bi-allélique du gène NF2. Signe pathogonomique d’une pathologie rare et héréditaire, la Neurofibromatose de type 2 (NF2), ils peuvent aussi apparaître de façon sporadique. Hormis la chirurgie ou la radiothérapie, peu d’options pharmacologiques sont proposées aux patients porteurs de schwannomes, principalement à cause du peu de cibles thérapeutiques identifiées. Dans les cellules de Schwann, le phénotype cellulaire associé à la perte NF2 est une perte d’inh

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Provenzano, Lucy. "The role of cellular prion protein in the development of schwannomas and other Merlin-deficient tumours." Thesis, University of Plymouth, 2018. http://hdl.handle.net/10026.1/10784.

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Neurofibromatosis type 2 (NF2) is an inherited, multiple tumour disease caused by loss of the tumour suppressor protein, Merlin. There are several tumours associated with NF2 including; ependymomas, meningiomas and schwannomas. Merlin loss can also occur sporadically in all of these tumours and is associated with upregulation of various growth factor receptors and their relevant signalling pathways. At present the only treatment options for NF2 are surgery or radiosurgery, both of which incur serious morbidity and are unable to prevent recurrence of tumours. Either new drug treatments, or re-p

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Andersson, Malin, and Daniel Svensson. "Impacts on teachers' lives of a capacity building course: A case study in rural Rajasthan, India." Thesis, Linnéuniversitetet, Institutionen för pedagogik, psykologi och idrottsvetenskap, PPI, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-12807.

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This case study is conducted on teachers working in Non-Formal Education centers (NFE's), for the Non-Governmental Organization Seva Mandir, in the Udaipur district in Rajasthan, India. The setting for the study is remote rural villages around the small city Udaipur, with one million inhabitants. The purpose of this case study is to investigate what impact the capacity building course that Seva Mandir offers the teachers, the NFE certification course, have had on the teacher’s lives. The aim is to get a picture of the overall impact of the course on a professional level and on the individual N

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Schulz, Alexander [Verfasser], Reinhard [Akademischer Betreuer] Wetzker, Reinhard [Akademischer Betreuer] Bauer, and Stephan [Akademischer Betreuer] Baader. "Die Rolle des Tumorsuppressorproteins Merlin bei der Pathogenese von NF2-assoziierter Polyneuropathie / Alexander Schulz. Gutachter: Reinhard Wetzker ; Reinhard Bauer ; Stephan Baader." Jena : Thüringer Universitäts- und Landesbibliothek Jena, 2015. http://d-nb.info/1066238359/34.

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McLain, John. "The Deletion of Exon 2 in the Nf2 Gene Leads to Changes in Morphology, Protein Expression, and Localization in Mouse Schwann Cells." Honors in the Major Thesis, University of Central Florida, 2007. http://digital.library.ucf.edu/cdm/ref/collection/ETH/id/1179.

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This item is only available in print in the UCF Libraries. If this is your Honors Thesis, you can help us make it available online for use by researchers around the world by following the instructions on the distribution consent form at http://library.ucf.edu/Systems/DigitalInitiatives/DigitalCollections/InternetDistributionConsentAgreementForm.pdf You may also contact the project coordinator, Kerri Bottorff, at kerri.bottorff@ucf.edu for more information.<br>Bachelors<br>Burnett School of Biomedical Sciences<br>Molecular Biology & Microbiology

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Islam, Mohammed Mehrul. "An analysis of the role of extension methodology on poverty reduction : a comparative study of aquaculture extension programmes in the Northwest Fisheries Extension Project (NFEP) command area, Bangladesh." Thesis, University of Wolverhampton, 2002. http://hdl.handle.net/2436/29559.

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The current deficiencies of extension interventions in aquaculture in Bangladesh, in particular, in the North-west have been examined. The importance of the inclusion of a social dimension in development interventions has been reviewed. Aquaculture, extension, social development and poverty are defined in the context of the study and a model of their interactions is proposed and used to elucidate the role of aquaculture in poverty reduction. Research questions were generated to examine the contention that ‘Aquaculture Extension Approaches that fail to substantially address social development w

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Lyons, Rimmer Jade. "The potential of CRL4-DCAF1 and KSR1 as therapeutic targets in low-grade Merlin-deficient tumours." Thesis, University of Plymouth, 2018. http://hdl.handle.net/10026.1/12833.

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Merlin is a tumour suppressor protein that is frequently mutated or downregulated in cancer. Biallelic Merlin inactivation is causative of tumour formation, including schwannoma, meningioma and ependymoma. These tumours can occur sporadically or as part of the genetic condition Neurofibromatosis type 2 (NF2) and cause significant morbidity. The current treatment options are restricted to surgery and radiotherapy, which are invasive and may cause further tumour development. The activity of both the E3 ubiquitin ligase complex Cullin 4 really interesting new gene (RING) E3 ubiquitin ligase- DNA

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Louw, Amber. "The added value of BAP1 immunohistochemistry and fluorescence in situ hybridisation for CDKN2A/p16 and NF2 in the diagnosis and prognostication of pleural mesothelioma." Thesis, Edith Cowan University, Research Online, Perth, Western Australia, 2023. https://ro.ecu.edu.au/theses/2661.

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Background: Mesothelioma is a rare but aggressive malignancy with therapeutic options that are generally palliative. The malignancy can be challenging to diagnose, commonly due to scant samples, often requiring patients to undergo multiple procedures before a definitive diagnosis can be reached. In more recent years ancillary tests based on the common molecular alterations in the disease have become more widely available to pathologists. However, the role of these investigations in the diagnostic process, identification of early disease and the implications for therapeutic options are not well

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Mönch, Dina [Verfasser], and German [Akademischer Betreuer] Ott. "Identifizierung von Zielmolekülen für die innovative Therapie pleuraler Mesotheliome : Untersuchung von Tyrosinkinasen sowie Komponenten der NF2/mTOR- und p14/p16-Signalwege / Dina Mönch ; Betreuer: German Ott." Hohenheim : Kommunikations-, Informations- und Medienzentrum der Universität Hohenheim, 2020. http://d-nb.info/1220774723/34.

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Andujar, Pascal. "Altérations génétiques des tumeurs respiratoires humaines et murines après exposition à des fibres minérales." Thesis, Paris Est, 2008. http://www.theses.fr/2008PEST0030.

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L’objectif était de mieux définir les relations entre l’exposition à certaines fibres minérales et les anomalies génétiques somatiques associées à la transformation tumorale de cellules de l’appareil respiratoire. Deux études indépendantes ont été conduites à partir du modèle murin Nf2+/- de mésothéliome malin (MM) développé dans le laboratoire, exposé par inoculation intrapéritonéale à des fibres d’amiante crocidolite (souris abs-Nf2+/- et abs-Nf2+/+) et à des fibres céramiques réfractaires (FCR) (souris ceram-Nf2+/-).Ce choix a été fondé selon une stratégie raisonnée à partir de la connaissa

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Frykholm, Carina. "Clinical and Genetic Studies of Hearing Impairment." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Universitetsbiblioteket [distributör], 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8290.

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Moncrieffe, Melissa Lucille. "Analyzing a model of non-formal education for young people : a comparative case study of national programs in the United States and Scotland." Thesis, University of Edinburgh, 2016. http://hdl.handle.net/1842/23568.

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Non-formal education (NFE) has the potential to provide diverse learning opportunities for personal and professional development. Proponents of NFE conclude that it creatively and flexibly responds to ever-changing socio-economic challenges. In practice, these contributions are highly dependent upon the viability of NFE and the context in which it is delivered. This research studied US and Scottish national community education programs, designed for vulnerable and disadvantaged youth, in order to examine NFE. As a comparative case study, the research developed a model of NFE from the literatur

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Worseck, Josephine [Verfasser], Christian [Akademischer Betreuer] Spahn, Erich E. [Akademischer Betreuer] Wanker, and Hans [Akademischer Betreuer] Lehrach. "Characterization of phosphorylation-dependent interactions involving neurofibromin 2 (NF2, merlin) isoforms and the Parkinson protein 7 (PARK7, DJ1) / Josephine Maria Worseck. Gutachter: Christian Spahn ; Erich E. Wanker ; Hans Lehrach." Berlin : Humboldt Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2012. http://d-nb.info/1023931621/34.

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Ivins, Tiffany. "Localization of Open Educational Resources (OER) in Nepal: Strategies of Himalayan Knowledge-Workers." BYU ScholarsArchive, 2011. https://scholarsarchive.byu.edu/etd/2616.

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This dissertation examines localization of Open Educational Resources (OER) in Himalayan community technology centers of Nepal. Specifically, I examine strategies and practices that local knowledge-workers utilize in order to localize educational content for the disparate needs, interests, and ability-levels of learners in rural villages. This study draws on insights from non-formal education (NFE) stakeholders in Nepal, including government, UN, international and national NGOs, local knowledge-workers, and learners from different villages. I specifically focus on a sample of seven technology

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横山, 俊彦, 啓隆長田, 秀樹村上 та ін. "O-28 YAP1は悪性胸膜中皮腫の増殖を促進し,NF2腫瘍抑制遺伝子で機能阻害される". 日本肺癌学会, 2007. http://hdl.handle.net/2237/11031.

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Buckley, Patrick. "Development and Application of Microarray-Based Comparative Genomic Hybridization : Analysis of Neurofibromatosis Type-2, Schwannomatosis and Related Tumors." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4786.

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Wu, Yi-Ci, and 巫逸琦. "NFE2-related factor 2 (Nrf2) in neurodegenerative disease: promoter polymorphism and therapeutic strategy targeting oxidative stress." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/52764583766979550531.

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碩士<br>國立臺灣師範大學<br>生命科學研究所<br>100<br>Nuclear factor-erythroid 2 (NF-E2)-related factor 2 (Nrf2) is a member of the basic leucine zipper transcription factors that regulate the expression of many antioxidant pathway genes and maintains cellular redox homeostasis. Increased oxidative stress is involved in the pathogenesis of many neurodegenerative diseases. For example, oxidative stress has been implicated as a major contributing factor in Parkinson’s disease (PD) and varying efficiency in the oxidative protection by Nrf2 may influence PD pathogenesis. In polyQ-mediated spinocerebellar ataxias, t

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Huang, Zih-Ming, and 黃梓銘. "Utilized NFES piezoelectric fibers to fabricate all-directional or transparent graphene-based generators." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/61732667263805846646.

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碩士<br>國立中央大學<br>機械工程學系<br>103<br>In this thesis, the near-field electrospinning (NFES) technique was used to investigate the piezoelectric fibers and fabricated the nanogenerators. The major research focused on (1) Massively aligned nanofibers-based nanogenerator deposited via near-field electrospinning, (2) An arbitrarily directional piezoelectric fiber-based nanogenerator with concentric circle topography via near-field electrospinning, (3) A transparent and flexible graphene-piezoelectric fiber generator. We demonstrate a direct-write, in-situ poled polyvinylidene fluoride (PVDF) nanofiber

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Fan, Kai-Chun, and 范凱鈞. "Linkage Identification by NFE Estimation: A Practical View of Building Blocks." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/75775699893946234753.

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碩士<br>國立臺灣大學<br>電機工程學研究所<br>99<br>Competent genetic algorithms (competent GAs) identify linkages between genes and build models via various mechanisms to solve problems. They have been applied for real world applications, but whether the models given by them match what are really preferred to solve the problems is yet unknown. This thesis proposes using the number of function evaluation (Nfe) to measure the performance of models and defines the optimal model to be the one that consumes the fewest Nfe for GAs to solve a specific problem. Then the building blocks (BBs) that construct the optimal

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Wiederhold, Thorsten [Verfasser]. "Characterization of neurofibromatosis 2 (NF2) tumor suppreor binding proteins / vorgelegt von Thorsten Wiederhold." 2001. http://d-nb.info/966515188/34.

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Vahldiek, Kai-Felix [Verfasser]. "Allelverluste bei Neurofibromatose Typ 2 (NF2) assoziierten Meningeomen / vorgelegt von Kai-Felix Vahldiek." 2001. http://d-nb.info/965649512/34.

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鄧旭真. "Molecular Characterization of Germline Mutations in Brain Tumor NF2 Gene and Breast Cancer BRCA2 Gene from Taiwan." Thesis, 1997. http://ndltd.ncl.edu.tw/handle/31752464570994698246.

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碩士<br>國立中山大學<br>生命科學研究所<br>85<br>Neurofibromatosis type 2 (NF2) is an autosomal dominantly inherited disease by bilateral vestibular schwannomas and other tumor of the brain, spinal cord, and central nervous system. NF2 disease is caused by germline mutations in the NF2 tumor suppressor gene on chromosome 22q12. Although the tumors of NF2 are histologically benign, their anatomical location and multiplicity lead to great morbidity and early mortality. Breast cancer is the most common malignancy among women in developed countries. Recently, the incidence of breast cancer increases n Taiw

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Schulze, Karin Marlies Marion [Verfasser]. "Herstellung rekombinanter Retroviren, In-vitro-Gentransfer und Expressionsanalyse des NF2-Gens Merlin / vorgelegt von Karin Marlies Marion Schulze." 2001. http://d-nb.info/962345210/34.

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