Littérature scientifique sur le sujet « Neural organoids »
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Articles de revues sur le sujet "Neural organoids"
Yu, Xiyao, Xiaoting Meng, Zhe Pei, Guoqiang Wang, Rongrong Liu, Mingran Qi, Jiaying Zhou et Fang Wang. « Physiological Electric Field : A Potential Construction Regulator of Human Brain Organoids ». International Journal of Molecular Sciences 23, no 7 (31 mars 2022) : 3877. http://dx.doi.org/10.3390/ijms23073877.
Texte intégralPflug, Florian G., Simon Haendeler, Christopher Esk, Dominik Lindenhofer, Jürgen A. Knoblich et Arndt von Haeseler. « Neutral competition explains the clonal composition of neural organoids ». PLOS Computational Biology 20, no 4 (22 avril 2024) : e1012054. http://dx.doi.org/10.1371/journal.pcbi.1012054.
Texte intégralLogan, Sarah, Thiago Arzua, Yasheng Yan, Congshan Jiang, Xiaojie Liu, Lai-Kang Yu, Qing-Song Liu et Xiaowen Bai. « Dynamic Characterization of Structural, Molecular, and Electrophysiological Phenotypes of Human-Induced Pluripotent Stem Cell-Derived Cerebral Organoids, and Comparison with Fetal and Adult Gene Profiles ». Cells 9, no 5 (23 mai 2020) : 1301. http://dx.doi.org/10.3390/cells9051301.
Texte intégralKim, Soo-hyun, et Mi-Yoon Chang. « Application of Human Brain Organoids—Opportunities and Challenges in Modeling Human Brain Development and Neurodevelopmental Diseases ». International Journal of Molecular Sciences 24, no 15 (7 août 2023) : 12528. http://dx.doi.org/10.3390/ijms241512528.
Texte intégralMensah-Brown, Kobina G., James Lim, Dennis Jgamadze, Guo-li Ming, Hongjun Song, John A. Wolf et Han-Chiao I. Chen. « 96101 Temporal Evolution of Neural Activity in Human Brain Organoids ». Journal of Clinical and Translational Science 5, s1 (mars 2021) : 23. http://dx.doi.org/10.1017/cts.2021.464.
Texte intégralBirch, Jonathan. « When is a brain organoid a sentience candidate ? » Molecular Psychology : Brain, Behavior, and Society 2 (18 octobre 2023) : 22. http://dx.doi.org/10.12688/molpsychol.17524.1.
Texte intégralTanaka, Yoshiaki, et In-Hyun Park. « Regional specification and complementation with non-neuroectodermal cells in human brain organoids ». Journal of Molecular Medicine 99, no 4 (2 mars 2021) : 489–500. http://dx.doi.org/10.1007/s00109-021-02051-9.
Texte intégralKatayama, Masafumi, Manabu Onuma, Noriko Kato, Nobuyoshi Nakajima et Tomokazu Fukuda. « Organoids containing neural-like cells derived from chicken iPSCs respond to poly:IC through the RLR family ». PLOS ONE 18, no 5 (4 mai 2023) : e0285356. http://dx.doi.org/10.1371/journal.pone.0285356.
Texte intégralZhou, Gang, Siyuan Pang, Yongning Li et Jun Gao. « Progress in the generation of spinal cord organoids over the past decade and future perspectives ». Neural Regeneration Research 19, no 5 (22 septembre 2023) : 1013–19. http://dx.doi.org/10.4103/1673-5374.385280.
Texte intégralLuo, Kevin. « Application of neural organoids in studying neurodegenerative diseases ». Theoretical and Natural Science 15, no 1 (4 décembre 2023) : 166–70. http://dx.doi.org/10.54254/2753-8818/15/20240474.
Texte intégralThèses sur le sujet "Neural organoids"
Omer, Attya. « Modeling human neural development and diseases using pluripotent stem cells ». Thesis, Université Paris-Saclay (ComUE), 2017. http://www.theses.fr/2017SACLS589.
Texte intégralMicrocephaly is a neurological condition, resulting in patients having a small head circumference, intellectual impairment and brain anatomical defects. A pre-requisite for achieving a better understanding of the cellular events that contribute to the striking expansion of the human cerebral cortex is to elucidate cell-division mechanisms, which likely go awry in microcephaly. Most of the mutated genes identified in microcephaly patient encode centrosomal protein, KNL1 is the only gene that encodes a kinetochore protein, it plays a central role in kinetochore assembly and function during mitosis. While the involvement of centrosome functions is well established in the etiology of microcephaly, little is known about the contribution of KNL1.In an attempt to assess the role of KNL1 in brain development and its involvement in microcephaly, we generated isogenic human embryonic stem cell (hESC) lines bearing KNL1 patient mutations using CRISPR/Cas9-mediated gene targeting. We demonstrated that the point mutation leads to KNL1 reduction in neural progenitors. Moreover, mutant neural progenitors present aneuploidy, an increase in cell death and an abrogated spindle assembly checkpoint. Mutant fibroblasts, derived from hESC, do not have a reduced expression of KNL1 and do not present any defect in cell growth or karyotype, which highlight a brain-specific phenotype.The subsequent differentiation of mutant neural progenitors into two-dimensional neural culture leads to the depletion of neural progenitors in the favor of premature differentiation. We developed a three-dimensional neural spheroids model from neural progenitors and reported a reduced size of mutant neural spheroids, compare to control. Lastly, using knockdown and rescue assays, we proved that protein level of KNL1 is responsible of the premature differentiation and the reduced size.These data suggest that KNL1 has a brain-specific function during the development. Changes in its expression might contribute to the brain phenotypic divergence that appeared during human evolution
Workman, Michael J. « Generating 3D human intestinal organoids with an enteric nervous system ». University of Cincinnati / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1416570664.
Texte intégralKlaus, Johannes [Verfasser], et Magdalena [Akademischer Betreuer] Götz. « Modeling neuronal heterotopias using iPSC derived neural stem cells, neurons and cerebral organoids derived from patients with mutations in FAT4 and DCHS1 / Johannes Klaus ; Betreuer : Magdalena Götz ». München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2017. http://d-nb.info/1148275789/34.
Texte intégralPrudon, Nicolas. « Integrative study, from the cell to the animal model, of the development of a cell therapy for Parkinson's disease ». Electronic Thesis or Diss., Bordeaux, 2024. http://www.theses.fr/2024BORD0071.
Texte intégralA breadth of preclinical studies is now supporting the rationale of pluripotent stem cell-derived cell replacement therapies to alleviate motor symptoms in Parkinsonian patients. Replacement of the primary dysfunctional cell population in the disease, i.e. the A9 dopaminergic neurons, is the major focus of these therapies. To achieve this, most therapeutical approaches involve grafting single-cell suspensions of DA progenitors. However, a considerable number of cells die during the transplantation process, as cells face anoïkis. One potential solution to address this challenge is to graft solid preparations, i.e. adopting a 3D format. Cryopreserving such format remains a major hurdle and is not exempt from causing delays in the time to effect, as observed with the use of cryopreserved single-cell DA progenitors. The work of this thesis focus on the development of 3D neural microtissues as a cell therapy for PD. The use of a high-throughput cell-encapsulation technology coupled with bioreactors to provide a 3D culture environment enabled the directed differentiation of hiPSCs into neural microtissues. The proper patterning of these neural microtissues into a midbrain identity was confirmed using orthogonal methods including qPCR, RNAseq, flow cytometry and immunofluorescent microscopy. The efficacy of the neural microtissues was demonstrated in a dose-dependent manner in non-clinical studies, using the 6-OHDA-lesioned hemiparkinsonian rat model. The grafts were characterized by post-mortem histological analysis, demonstrating the presence of human dopaminergic neurons projecting into the host striatum. The work reported here is the first bioproduction of a cell therapy for Parkinson’s disease in a scalable bioreactor, leading to a full behavioural recovery 16 weeks in the animal model after transplantation using cryopreserved 3D cell format
FARIA, PEREIRA MARLENE CRISTINA. « EPIGENETIC AND FUNCTIONAL ASSESSMENT OF ENHANCEROPATHIES ACROSS HUMAN MODELS : FOCUS ON GABRIELE-DE VRIES SYNDROME ». Doctoral thesis, Università degli Studi di Milano, 2022. https://hdl.handle.net/2434/945230.
Texte intégralBaillie-Johnson, Peter. « The generation of a candidate axial precursor in three dimensional aggregates of mouse embryonic stem cells ». Thesis, University of Cambridge, 2017. https://www.repository.cam.ac.uk/handle/1810/267818.
Texte intégralEldred, Megan. « Investigating cellular and molecular mechanisms of neuronal layering in self-organising aggregates of zebrafish retinal cells ». Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/284080.
Texte intégralForlivesi, Claudio. « Biomateriali e 3D bioprinting nella rigenerazione neurale ». Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2019. http://amslaurea.unibo.it/17888/.
Texte intégralPagliaro, Sarah Beatriz De Oliveira. « Transcriptional control induced by bcr-abl and its role in leukemic stem cell heterogeneity. Single-Cell Transcriptome in Chronic Myeloid Leukemia : Pseudotime Analysis Reveals Evidence of Embryonic and Transitional Stem Cell States Single Cell Transcriptome in Chronic Myeloid Leukemia (CML) : Pseudotime Analysis Reveals a Rare Population with Embryonic Stem Cell Features and Druggable Intricated Transitional Stem Cell States A novel neuronal organoid model mimicking glioblastoma (GBM) features from induced pluripotent stem cells (iPSC) Experimental and integrative analyses identify an ETS1 network downstream of BCR-ABL in chronic myeloid leukemia (CML) ». Thesis, université Paris-Saclay, 2020. http://www.theses.fr/2020UPASQ032.
Texte intégralChronic myeloid leukemia is a clonal hematopoietic malignancy, characterized by the acquisition of the t (9;22) translocation leading to Ph1 chromosome and its counterpart BCR-ABL oncogene, in a very primitive hematopoietic stem cell. CML is a model of targeted therapies as the proof of concept of the feasibility of targeting the tyrosine kinase (TK) activity BCR-ABL using TK inhibitors (TKI) has been shown to lead to major responses and remissions. However, the current problems encountered in these therapies are primitive leukemic stem cells resistance and their persistence which is thought to be related to the heterogeneity of the stem cells at diagnosis leading to clonal selection of cells resisting to TKI therapies. I have applied the technology of single cell transcriptome analysis to CML cells using a panel of genes involved in different pathways combined with trajectory inference analysis to the gene expression pattern. The results showed a transitional stem cell states including embryonic genes identified in CML cells at diagnosis which could contribute to LSC resistance and persistence. Furthermore, the oncoprotein Bcr-Abl is the constitutively active tyrosine kinase produced by the chimeric BCR-ABL gene in chronic myeloid leukemia (CML). The transcriptional targets of Bcr-Abl in leukemic cells have not been extensively studied. A transcriptome experiment using the hematopoietic UT7 cell line expressing BCR-ABL, has identified the overexpression of eukaryotic elongation factor kinase 2 (eEF2K) which plays a major role in the survival of cells upon nutrient deprivation. Overall, the data suggest that overexpression of eEF2K in CML is associated with an increased sensitivity to nutrient-deprivation
Livres sur le sujet "Neural organoids"
The Emerging Field of Human Neural Organoids, Transplants, and Chimeras. Washington, D.C. : National Academies Press, 2021. http://dx.doi.org/10.17226/26078.
Texte intégralNational Academies of Sciences, Engineering, and Medicine. Emerging Field of Human Neural Organoids, Transplants, and Chimeras : Science, Ethics, and Governance. National Academies Press, 2021.
Trouver le texte intégralAffairs, Policy and Global, Technology, and Law Committee on Science, National Academies of Sciences, Engineering, and Medicine et Committee on Ethical, Legal, and Regulatory Issues Associated with Neural Chimeras and Organoids. Emerging Field of Human Neural Organoids, Transplants, and Chimeras : Science, Ethics, and Governance. National Academies Press, 2021.
Trouver le texte intégralAffairs, Policy and Global, Technology, and Law Committee on Science, National Academies of Sciences, Engineering, and Medicine et Committee on Ethical, Legal, and Regulatory Issues Associated with Neural Chimeras and Organoids. The Emerging Field of Human Neural Organoids, Transplants, and Chimeras : Science, Ethics, and Governance. National Academies Press, 2022.
Trouver le texte intégralChapitres de livres sur le sujet "Neural organoids"
Sakaguchi, Hideya, et Nozomu Takata. « Stem Cell-Derived Neural Organoids : From the Origin to Next Generation ». Dans Handbook of Stem Cell Applications, 1–19. Singapore : Springer Nature Singapore, 2023. http://dx.doi.org/10.1007/978-981-99-0846-2_6-1.
Texte intégralSebastian, Rebecca, Narciso S. Pavon, Yoonjae Song, Karmen T. Diep et ChangHui Pak. « Method to Generate Dorsal Forebrain Brain Organoids from Human Pluripotent Stem Cells ». Dans Stem Cell-Based Neural Model Systems for Brain Disorders, 169–83. New York, NY : Springer US, 2023. http://dx.doi.org/10.1007/978-1-0716-3287-1_13.
Texte intégralMurray, Liam, Meagan N. Olson, Nathaniel Barton, Pepper Dawes, Yingleong Chan et Elaine T. Lim. « FACS-Based Sequencing Approach to Evaluate Cell Type to Genotype Associations Using Cerebral Organoids ». Dans Stem Cell-Based Neural Model Systems for Brain Disorders, 193–99. New York, NY : Springer US, 2023. http://dx.doi.org/10.1007/978-1-0716-3287-1_15.
Texte intégralTakahashi, Toshio. « New Trends and Perspectives in the Function of Non-neuronal Acetylcholine in Crypt–Villus Organoids in Mice ». Dans Methods in Molecular Biology, 145–55. New York, NY : Springer New York, 2016. http://dx.doi.org/10.1007/7651_2016_1.
Texte intégralGong, Jing, Jiahui Kang, Minghui Li, Xiao Liu, Jun Yang et Haiwei Xu. « Applications of Neural Organoids in Neurodevelopment and Regenerative Medicine ». Dans Organoids [Working Title]. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.104044.
Texte intégralBordoni, Matteo, Valentina Fantini, Orietta Pansarasa et Cristina Cereda. « From Neuronal Differentiation of iPSCs to 3D Neural Organoids : Modeling of Neurodegenerative Diseases ». Dans Recent Advances in Neurodegeneration. IntechOpen, 2019. http://dx.doi.org/10.5772/intechopen.80055.
Texte intégralEvans, John H. « Consciousness, the Human-Animal Foundational Distinction, and Ephemeral Connections to Humans ». Dans Disembodied Brains, 72–95. Oxford University PressNew York, 2024. http://dx.doi.org/10.1093/oso/9780197750704.003.0004.
Texte intégralTang, Chunling, Xinghui Wang, Eileen Gentleman et Nicholas A. Kurniawan. « Production of Neuroepithelial Organoids from Human-Induced Pluripotent Stem Cells for Mimicking Early Neural Tube Development ». Dans Methods in Molecular Biology. New York, NY : Springer US, 2024. http://dx.doi.org/10.1007/7651_2024_546.
Texte intégralJacob, Fadi, Jordan G. Schnoll, Hongjun Song et Guo-li Ming. « Building the brain from scratch : Engineering region-specific brain organoids from human stem cells to study neural development and disease ». Dans Current Topics in Developmental Biology, 477–530. Elsevier, 2021. http://dx.doi.org/10.1016/bs.ctdb.2020.12.011.
Texte intégralSharma, Maryada, Sonal Jangra, Shalini Dhiman, Sonam Yangzes, Anil Tiwari, Sourabha Kumar Patro, Keshav Sharma et al. « Leveraging neural crest pluripotency to extend retinal and craniofacial niches for building neurovascular organoids—a theranostic and drug development perspective ». Dans The Eye, Volume 4, 55–118. Elsevier, 2023. http://dx.doi.org/10.1016/b978-0-323-99987-8.00007-2.
Texte intégralActes de conférences sur le sujet "Neural organoids"
Shettigar, Nandan, Lamees El Nihum, Ashok Thyagarajan, Debjyoti Banerjee et Robert Krencik. « Design, Microfabrication and Testing of Brain-on-a-Chip (BOC) Platform Using Neural Organoids (Spheroids) ». Dans ASME 2021 Fluids Engineering Division Summer Meeting. American Society of Mechanical Engineers, 2021. http://dx.doi.org/10.1115/fedsm2021-65894.
Texte intégralWilson, Madison, Martin Thunemann, Francesca Puppo, Abed Mansour, Alysson R. Muotri, Duygu Kuzum et Anna Devor. « Transparent neural interface for in vivo interrogation of human organoids ». Dans Neural Imaging and Sensing 2021, sous la direction de Qingming Luo, Jun Ding et Ling Fu. SPIE, 2021. http://dx.doi.org/10.1117/12.2579350.
Texte intégralMacDonald, Michael, Randy Fennel, Asha Singanamalli, Nelly Cruz, Mohammad YousefHussein, Yousef Al-Kofahi et Benjamin Freedman. « Improved automated segmentation of human kidney organoids using deep convolutional neural networks ». Dans Image Processing, sous la direction de Bennett A. Landman et Ivana Išgum. SPIE, 2020. http://dx.doi.org/10.1117/12.2549830.
Texte intégralWilson, Madison N., Martin Thunemann, Francesca Puppo, Emily Martin, Rebeca Blanch, Fred H. Gage, Alysson R. Muotri, Anna Devor et Duygu Kuzum. « Investigation of functional integration of cortical organoids transplanted in vivo towards future neural prosthetics applications ». Dans 2023 11th International IEEE/EMBS Conference on Neural Engineering (NER). IEEE, 2023. http://dx.doi.org/10.1109/ner52421.2023.10123847.
Texte intégralZhang, Jinqiu, Jolene Ooi, Sarah R. Langley, Obed Akwasi Aning, Magdalena Renner, Chit Fang Cheok, Enrico Petretto, Juergen A. Knoblich et Mahmoud A. Pouladi. « A48 Expanded HTT cag repeats disrupt the balance between neural progenitor expansion and differentiation in isogenic human cerebral organoids ». Dans EHDN 2018 Plenary Meeting, Vienna, Austria, Programme and Abstracts. BMJ Publishing Group Ltd, 2018. http://dx.doi.org/10.1136/jnnp-2018-ehdn.46.
Texte intégralPitta, Marina Galdino da Rocha, Jordy Silva de Carvalho, Luzilene Pereira de Lima et Ivan da Rocha Pitta. « iPSC therapies applied to rehabilitation in parkinson’s disease ». Dans XIII Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1516-3180.022.
Texte intégralEl Nihum, Lamees, Nandan Shettigar, Debjyoti Banerjee et Robert Krencik. « A Comprehensive Review of Three-Dimensional Neuro-Organoids and Engineering Brain-on-a-Chip Microfluidic Devices ». Dans ASME 2021 Fluids Engineering Division Summer Meeting. American Society of Mechanical Engineers, 2021. http://dx.doi.org/10.1115/fedsm2021-65892.
Texte intégralBahr, AS, M. Simon, D. Capper, O. Witt, T. Milde, F. Selt, J. Buhl, H. Stachelscheid et P. Hernáiz Driever. « Modeling low-grade glioma with cerebral organoids ». Dans 28th Annual Meeting of the working group “Experimental Neuro-Oncology”. Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0039-1696327.
Texte intégralMa, Yuanzheng, Davit Khutsishvili, Zitian Wang, Xun Guan et Shaohua Ma. « Exploring the Neural Organoid in High Definition : Physics-Inspired High-Throughout Super-Resolution 3D Image Reconstruction ». Dans 2023 Asia Communications and Photonics Conference/2023 International Photonics and Optoelectronics Meetings (ACP/POEM). IEEE, 2023. http://dx.doi.org/10.1109/acp/poem59049.2023.10368794.
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