Littérature scientifique sur le sujet « Neoplastic lesion »
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Articles de revues sur le sujet "Neoplastic lesion"
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Ali Naqvi, Syed Muhammad. « Frequency and pattern of salivary gland lesions at a tertiary care centre ». Isra Medical Journal 14, no 2 (30 juin 2022) : 50–54. http://dx.doi.org/10.55282/imj.oa1279.
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Objective: To analyze the frequency and histo-morphological pattern of non-neoplastic and neoplastic salivary gland lesions at a tertiary care centre. Study Design: Retrospective descriptive cross-sectional study Place and Duration: Histopathology section, Dow Diagnostic Reference and Research Laboratory, Karachi from 1st February 2021 to 31st July, 2021. Methodology: Data of all salivary gland lesions were retrieved from institutional database. All tissue specimens of parotid, submandibular and sublingual salivary glands lesions as well as possible minor salivary glands swellings were included for histopathological analysis. Type of benign or neoplastic lesion along with salivary gland involved were assessed. Results: Out of a total of 739 samples, 28.0% were non-neoplastic whereas 72.0% were neoplastic lesions. Out of 207 non-neoplastic lesions, 55.1% were of inflammatory origin whereas 44.9% were mucoceles. Chronic sialadenitis (61.4%) was the most common non-neoplastic inflammatory lesion. Among mucoceles, those reported with no specification of type predominated (37.6%). Out of total 543 neoplastic lesions, 53.1% were benign whereas 19.3% were malignant. Pleomorphic adenoma (87.1%) was the commonest benign neoplastic lesion, followed by benign epidermal inclusion cysts (3.7%). Of the 127 malignant salivary gland tumors, mucoepidermoid carcinoma (39.4%) was the most common lesion, followed by adenoid cystic carcinoma (29.1%). Conclusion: Chronic sialadenitis was the most common non-neoplastic lesion whereas pleomorphic adenoma was the predominant benign lesion. Moreover, mucoepidermoid carcinoma was the most common malignant lesion followed by adenoid cystic carcinoma. Keywords: Salivary Glands, Neoplastic lesion, Non-neoplastic lesion, Frequency, Sialadenitis, Adenoma, Carcinoma
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Singh, Mrinalini, KK Jha, SU Kafle, R. Rana et P. Gautam. « Histopathological Analysis of Neoplastic and Non-Neoplastic Lesions of Ovary : A 4 Year Study in Eastern Nepal ». Birat Journal of Health Sciences 2, no 2 (2 novembre 2017) : 168–74. http://dx.doi.org/10.3126/bjhs.v2i2.18519.
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IntroductionOvarian neoplastic and nontineoplastic lesions form a pelvic mass and cause gynaecological problems. Therefore, proper recognization and classification is important for appropriate therapy.ObjectiveTo study the morphological patiern and classify the neoplastic and nontineoplastic ovarian lesions in terms of age and size.MethodologyA retrospective study conducted at Sriram Diagnostic Clinic, Biratnagar, Nepal and Birat Medical College, Tankisinwari, Morang, Nepal during a period of March 2012 to February 2016. All abdominal hysterectomy specimens with bilateral or unilateral salpingo-oophorectomy and all ovarian surgeries presenting with either solid or cystic ovarian lesions were included in the study for histopathological analysis. Normal appearing ovaries on gross and microscopic examination were excluded from the study.ResultsA total of 522 cases were studied. Out of which 329 (63%) were non-neoplastic and 193 (37%) were neoplastic. Follicular cysts comprised of 112 (34%) cases, and it was the most common non neoplastic lesion. The age of patients with non-neoplastic lesions and neoplastic lesions varied from 16-54 years and 13-72 years respectively. Size of nonneoplastic and neoplastic lesions varied from 2-12 cm and 2- 19 cm respectively. Among the 193 neoplastic ovarian lesions, 181 (94 %) were benign, as well as 4 (2%) were borderline and 8 (4 %) were malignant. Mature cystic teratoma was the commonest benign tumor followed by Serous cystadenoma. Serous cystadenocarcinoma was the commonest occurring malignant tumor followed by Mucinouscystadenocarcinoma.ConclusionVarying types of both non neoplastic and neoplastic ovarian lesion were seen. Among the non-neoplastic and neoplastic lesion, the most commonly encountered lesion was follicular cyst and mature cystic teratoma respectively.Birat Journal of Health SciencesVol.2/No.1/Issue 2/ Jan - April 2017, Page: 168-174
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Cassinotti, Andrea, Paolo Fociani, Piergiorgio Duca, Manuela Nebuloni, Sophia Elizabeth Campbell Davies, Gianluca Sampietro, Federico Buffoli, Alberto Corona, Giovanni Maconi et Sandro Ardizzone. « Modified Kudo classification can improve accuracy of virtual chromoendoscopy with FICE in endoscopic surveillance of ulcerative colitis ». Endoscopy International Open 08, no 10 (22 septembre 2020) : E1414—E1422. http://dx.doi.org/10.1055/a-1165-0169.
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Abstract Background and study aims Virtual chromoendoscopy with Fuji Intelligent Color Enhancement (FICE) has never been studied in prospective trials of endoscopic surveillance for ulcerative colitis (UC). We compared FICE and white light endoscopy (WLE) in differentiation of visible lesions in UC. Patients and methods In a prospective parallel study, we compared consecutive outpatients with UC submitted to surveillance colonoscopy with FICE or WLE. At least one visible polypoid or non-polypoid lesion for each patient was required. Random biopsies from normal mucosa, targeted biopsies or removal of suspected neoplastic lesions and targeted biopsies of unsuspected lesions were performed. In the FICE arm, neoplasia was suspected according to a modified Kudo classification (FICE-KUDO/inflammatory bowel disease [IBD]). Sensitivity (SE), specificity (SP), positive and negative likelihood ratios (LR) and negative predictive value (NPV) were analyzed. Results One hundred patients were submitted to FICE (n = 46) or WLE (n = 54). Twenty-two patients (11 in WLE, 11 in FICE) had a least one neoplastic lesion. No neoplasia was found in random biopsies. Among 275 lesions, 17 of 136 by FICE and 27 of 139 by WLE were suspected neoplasia, but 28 (14 in each arm) were true neoplastic lesions. The accuracy of FICE-KUDO/IBD vs WLE (per lesion) was: SE 93 % vs 64 % (P = 0.065), SP 97 % vs 86 % (P = 0.002), positive-LR 28.3 vs 4.5 (P = 0.001), negative-LR 0.07 vs 0.42 (P = 0.092), NPV 99 % vs 96 % (P = 0.083). FICE-KUDO/IBD detected more non-polypoid lesions than WLE (P = 0.016). Conclusions Targeted biopsies of polypoid and non-polypoid lesions, using the modified Kudo classification with FICE are more accurate than WLE in UC surveillance.
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Gupta, Urvashi, Ruchi Shrestha, Ashok P. Samdurkar et Anita Shahi. « A Histopathological Study of Neoplastic Lesions of Conjunctiva ». Journal of Universal College of Medical Sciences 4, no 1 (24 janvier 2018) : 32–35. http://dx.doi.org/10.3126/jucms.v4i1.19077.
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BACKGROUND: Ocular malignant tumors are relatively rare compared to other eye lesions, require immediate diagnosis and management. But ignorant care due to unawareness of persons can result into debility, loss of vision, and occasionally life is jeopardized.1 The aim of the study is to determine the frequency of most common neoplastc lesions of conjunctiva with histopathologically confirmed diagnosis. MATERIAL AND METHODS: It was a retrospective cross-sectional study done in a period of two years (January 2011 December 2012) that included120 patients who presented with conjunctival lesions to the pathology department of Universal College of Medical Science, Bhairahawa, Nepal. RESULTS: In this study out of 120 biopsies which were histopathologically diagnosed as conjunctival neoplasms were categorized into benign, dysplastic and malignant lesion and was common after second decade of life. Majority of cases (75 cases, 62.5%) were categorized as benign lesion with predominance of squamous papilloma (n=25) and nevus (n=21), followed by malignant lesion (27 cases, 22.5%) and dysplastic lesions (18 cases, 15%). Amongst malignancies, squamous cell carcinoma (SCC) was the most prevalent and a case of malignant melanoma was studied. Dysplastic lesion included conjunctival intraepithelial neoplasia (CIN) with and without squamous papilloma. CONCLUSION: Histopathology plays an important role in diagnosis of conjunctival lesions and rules out different categories of neoplastic lesions on routine basis. In this study Squamous cell carcinoma (SCC) 20.01% is the most common malignant tumor of conjunctiva. The next majority of cases diagnosed as the verrucuous carcinoma 1.66% and malignant melanoma 0.83% maximum case of malignant cases diagnosed in the age group of more than 50 years. Journal of Universal College of Medical Sciences (2016) Vol.04 No.01 Issue 13, Page: 32-35
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Dhawle, Manjusha, Ashwini Tangde, Anil Joshi et Rajan Bindu. « Clinicopathological study of testicular lesions ». International Journal of Research in Medical Sciences 7, no 4 (27 mars 2019) : 1319. http://dx.doi.org/10.18203/2320-6012.ijrms20191346.
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Background: Testis is affected by both neoplastic and non neoplastic conditions. Non neoplastic lesions of the testis include epididymo-orchitis, testicular atrophy, undescended testis, testicular abscess etc. Testicular tumors are relatively rare. They constitute the 4th most common cause of death from neoplasia in the young males. This study was undertaken to study the histopathological spectrum, age wise distribution and clinical symptoms of testicular lesions.Methods: This is a retrospective study of three years conducted in the department of pathology, Aurangabad from June 2015 to May 2018. It included all the orchidectomy specimens received from the department of surgery and excluded the orchidectomy specimens sent for infertility and prostatic carcinoma. A detail clinical history was taken. Histopathological examination was done after routine processing and staining with H and E. The data collected was tabulated, analysed and compared to other similar studies.Results: We studied 70 cases. Non neoplastic testicular lesions were 57 and 13 were neoplastic. Non neoplastic testicular lesions were more common than the neoplastic ones. Non neoplastic testicular lesions presented most commonly in the 2nd decade. Most common non neoplastic lesion was epididymo-orchitis followed by torsion, atrophy and testicular abscess. Most common neoplasm was malignant mixed germ cell tumor. Most of the patients of neoplasms presented in the 3rd decade. The most common complaint was testicular swelling and pain.Conclusions: Majority of testicular lesions are non neoplastic. Neoplastic lesions are rare. Non neoplastic lesions mimic neoplastic ones clinically, as testicular swelling is the most common complaint. So histopathological diagnosis is necessary for an accurate diagnosis of testicular lesions.
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Kedarisetty, Vidya. « Spectrum of esophageal lesions- A study of endoscopic biopsies ». IP Journal of Diagnostic Pathology and Oncology 6, no 2 (15 juin 2021) : 127–31. http://dx.doi.org/10.18231/j.jdpo.2021.027.
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Endoscopic biopsies is a very common outpatient procedure in gastroenterology unit. The present article is a study of endoscopic biopsies taken from the esophagus. The gastrointestinal tract cannot be visualized directly and endoscopy is a very important and easy tool for visualization of GI tract lesions directly and helping in the diagnosis in the early stage, there by helping in the overall well being of the patient. To emphasize the utility of endoscopic biopsies in the diagnosis of esophageal lesions. To correlate the endoscopic findings with pathological diagnosis. To study the various pathologies. Endoscopic biopsies taken from the esophagus were studied and analysed in the present study. The biopsies are taken by the gastroenterologist. The biopsies are fixed in 10%formalin.After fixation the biopsy specimen is processed and embedded in paraffin.4 to 5 microns thick sections were cut, stained with Haematoxylin & Eosin and studied. Out of the 118 cases of esophageal biopsies received at the Department of Pathology, Mediciti Institute of Medical Sciences from December 2016 to November, 2018. ,50 were non neoplastic lesions, 68 cases were neoplastic lesions, 50 were non neoplastic lesions, 68 cases were neoplastic lesions. Chronic non specific esophagitis was the commonest non neoplastic esophageal lesion. Squamous cell carcinoma was the commonest neoplastic lesion. The lower one third is the commonest site of pathology for esophagus. Males are mostly effected and predominant age of presentation is around 40-60 years for non neoplastic lesion and 50-70 years for neoplastic region.
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Sawant, Amod, et Suresh Mahajan. « Histopathological Study of Ovarian Lesions at a Tertiary Health Care Institute ». MVP Journal of Medical Sciences 4, no 1 (22 mai 2017) : 26. http://dx.doi.org/10.18311/mvpjms/0/v0/i0/724.
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Background: Ovary is the commonest site of neoplastic and nonneoplastic lesion, can present in childhood to postmenopausal age group and accounts for the most prevalent cause of hospital admissions. Aim: This study was done to analyse the frequency of ovarian lesions their histological features in a tertiary health care centre. Materials and Methods: This is a prospective study of 143 ovarian lesions at tertiary care hospital over a period of 3yr. All the relevant data of patients analysed from hospital record file. Results: The total number of ovarian lesions studied during study period was 143 cases, amongst them 110 were non-neoplastic and remaining 33 were neoplastic. The most common non-neoplastic lesion seen was solitary follicular cysts i.e. 77 cases (70%), followed by corpus luteal cysts 14 cases (12.7%). Among the 33 neoplastic ovarian lesions 25(75.7%) cases were benign, 2(6.1%) case was at borderline and 6 (18.2%) cases were malignant. In benign ovarian neoplasm, most commonly seen lesion were serous cystadenoma followed by benign cystic teratoma. In malignant cases, maximum were of serous cystadenocarcinoma, followed by endometrioid carcinoma and 2 cases of sex-cord stromal tumours (fibromas) were observed metastatic tumours. Conclusion: Ovarian lesion possess wide gamut of histology. Specific diagnoses are made on routine gross and histological examination.
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Sudiono, Janti, Barnabas Howuk et Cindy Fransisca. « Macrophage and angiogenesis intensity within proliferative non neoplastic and neoplastic oral lesions ». Padjadjaran Journal of Dentistry 30, no 3 (30 novembre 2018) : 215. http://dx.doi.org/10.24198/pjd.vol30no3.16851.
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The most common chronic inflammation involved dental and oral tissue is gingival polyp, pulp polyp, and fibroma that are proliferative non neoplastic and neoplastic condition. Chronic inflammation will induce cells and vascular proliferation as well as biological nature lesion. Previous study revealed that increase macrophage followed by increase angiogenesis intensity. Increase angiogenesis or vascular proliferation indicates progressive growth in form of proliferative non neoplastic or neoplastic disease outside of their easily bleeding clinical features. This study evaluated macrophage and angiogenesis intensity and their correlation within such oral lesions. Samples used are of oral mucosa excision with clinical diagnose of gingival polyp (n=3); pulp polyp (n=3); and fibroma (n=3). Macrophage was detected using immunostaining with CD68 antibody resulted in brown staining cell membrane under light microscope while angiogenesis intensity evaluated as number of blood vessels. The results showed there was mild positive correlation of angiogenesis intensity and CD68+ as macrophage marker with r=0.31. The angiogenesis intensity showed significant differences (p<0.05) with the highest was in pulp polyp (12.00) followed by fibroma (11.81) and gingival polyp (9.67), however there was no significant difference between non neoplastic lesion (pulp polyp) and neoplastic lesion (fibroma). The CD68+ expression showed no significant differences (p=0.102>0.05) with the highest was in fibroma (51.32±31.64%) followed by non neoplastic pulp polyp (45.82±15.94%) and gingival polyp (29.98±13.51%). This result was in accordance with the biological properties of lesions from the aspect of angiogenesis and macrophage intensity that can be used as parameter for determining the growth and prognosis of lesion.
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Bisschops, Raf, Talat Bessissow, Joseph A. Joseph, Filip Baert, Marc Ferrante, Vera Ballet, Hilde Willekens et al. « Chromoendoscopy versus narrow band imaging in UC : a prospective randomised controlled trial ». Gut 67, no 6 (11 juillet 2017) : 1087–94. http://dx.doi.org/10.1136/gutjnl-2016-313213.
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BackgroundPatients with long-standing UC have an increased risk for the development of colonic neoplastic lesions. Chromoendoscopy (CE) has been proven to enhance neoplasia detection while the role of virtual chromoendoscopy (VC) is still to be defined.ObjectiveTo compare the performance of CE to VC for the detection of neoplastic lesions in patients with long-standing UC.DesignA multicentre prospective randomised controlled trial. 131 patients with long-standing UC were randomised between CE with methylene blue 0.1% (n=66) or VC with narrow band imaging (NBI) (n=65). Biopsies were taken from visible lesions and surrounding mucosa. No random biopsies were performed. The primary outcome was the difference in total number of neoplastic lesions detected in each group.ResultsThere was no significant difference between NBI and CE for neoplasia detection. Mean number of neoplastic lesions per colonoscopy was 0.47 for CE and 0.32 for NBI (p=0.992). The neoplasia detection rate was not different between CE (21.2%) and NBI (21.5%) (OR 1.02 (95% CI 0.44 to 2.35, p=0.964). Biopsies from the surrounding mucosa yielded no diagnosis or dysplasia. The per lesion neoplasia detection was 17.4% for CE and 16.3% for NBI (OR 1.09 (95% CI 0.59 to 1.99, p=0.793). The total procedural time was on average 7 min shorter in the NBI group.ConclusionCE and NBI do not differ significantly for detection of colitis-associated neoplasia. Given the longer withdrawal time for CE and easier applicability, NBI may possibly replace classical CE.Trial registration numberNCT01882205; Results.
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Bal Gargade, Chitrawati, Archana Hemant Deshpande et Seetu Palo. « Histopathological spectrum of vulvar lesions on a remote Indian Island ». IP Archives of Cytology and Histopathology Research 6, no 3 (15 septembre 2021) : 153–59. http://dx.doi.org/10.18231/j.achr.2021.037.
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A wide spectrum of normal, benign, premalignant, and malignant lesions may occur on the vulva. Symptoms of vulvar disorders may be non-specific. Empiric treatment of vulvovaginal symptoms is common but usually not helpful. Though the varied clinical presentation and diverse histopathological spectrum of vulvar lesions have amazed Pathologists, only a few studies have been reported in the literature. The present study consists of a histopathological spectrum of vulvar lesions. 1.To evaluate the histopathological spectrum of vulvar lesions. 2. To compare the incidences of non-neoplastic and neoplastic lesions of the vulva. Present study includes all types of vulvar lesion specimens received in the Department of pathology over a period of four years. All thirty-nine vulvar biopsies received in the Department of Pathology were studied for histomorphologic features. The lesions were categorized as non-neoplastic, neoplastic. The neoplastic ones were further divided into benign, malignant, and premalignant. The age of the women ranged from 15 to 69 years (mean 36.18±12.71) with the maximum number of patients between 30 to 40 years of age. Non neoplastic lesions were more common (22; 56.4%) than the (17; 43.6%) neoplastic lesions. There were 15(38.5%) benign lesions while 2 cases (5.13%) were malignant. Among the non-neoplastic lesions, Bartholin's duct cyst was the most common histopathologic diagnosis (35.9%). The fibroepithelial polyp was the most common benign neoplastic lesion constituting 15.3%. In the present study nonneoplastic lesions were more common than neoplastic lesions. Among the neoplastic lesions, benign neoplasms were more frequent than malignant lesions.
Thèses sur le sujet "Neoplastic lesion"
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FRANCESCHINI, FABIO GIULIO. « Correlazioni esistenti tra parodontologia e medicina orale. Lesioni delle mucose orali versus malattia parodontale. Aspetti diagnostici e terapeutici ». Doctoral thesis, Università degli Studi di Milano-Bicocca, 2011. http://hdl.handle.net/10281/19339.
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Our study describes the relationship between periodontal disease and oral mucosal lesions. At first we analysed classification criteria of oral lesions in order to provide a point of reference for an adequate description. In a second time we started to describe periodontal disease, that is a common pathology all over the world with high costs for therapy and rehabilitations. Also classification of periodontal disease is important, because there are different types of disease, with various clinical aspects. We used the AAP (American Academy of Periodontology) classification of 1999, that reports: gingivitis, chronic periodontitis, aggressive periodontitis, periodontitis related to systemic diseases, necrotizing periodontitis, periodontal abscess, periodontitis associated to endodontic lesions, acquired and developed deformities and conditions. In the second part we described oral mucosal lesions, starting with infective diseases on the basis of etiologic agents: bacterial, viral (with viral neoplasms), fungal, parasitic and syphilitic lesions. In the third part we described autoimmune lesions, in particular the erythema multiform. In the fourth part we analysed the neoplastic and pre-neoplastic diseases, in particular squamous cell carcinoma and leukoplakia. Fifth section is dedicated to “border lesions”, because they are studied both in periodontology and oral medicine. These diseases are the desquamative gingivitis, lichen planus, pemphigoid, pemphigus, linear IgA disease, chronic ulcerative stomatitis and epulid.
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Cesari, Valentina <1985>. « High sensitivity analysis of BRAF mutations in neoplastic and non-neoplastic thyroid lesions ». Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2014. http://amsdottorato.unibo.it/6360/1/Cesari_Valentina_tesi.pdf.
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The clonal distribution of BRAFV600E in papillary thyroid carcinoma (PTC) has been recently debated. No information is currently available about precursor lesions of PTCs.
My first aim was to establish whether the BRAFV600E mutation occurs as a subclonal event in PTCs. My second aim was to screen BRAF mutations in histologically benign tissue of cases with BRAFV600E or BRAFwt PTCs in order to identify putative precursor lesions of PTCs. Highly sensitive semi-quantitative methods were used: Allele Specific LNA quantitative PCR (ASLNAqPCR) and 454 Next-Generation Sequencing (NGS).
For the first aim 155 consecutive formalin-fixed and paraffin-embedded (FFPE) specimens of PTCs were analyzed. The percentage of mutated cells obtained was normalized to the estimated number of neoplastic cells. Three groups of tumors were identified: a first had a percentage of BRAF mutated neoplastic cells > 80%; a second group showed a number of BRAF mutated neoplastic cells < 30%; a third group had a distribution of BRAFV600E between 30-80%. The large presence of BRAFV600E mutated neoplastic cell sub-populations suggests that BRAFV600E may be acquired early during tumorigenesis: therefore, BRAFV600E can be heterogeneously distributed in PTC.
For the second aim, two groups were studied: one consisted of 20 cases with BRAFV600E mutated PTC, the other of 9 BRAFwt PTCs. Seventy-five and 23 histologically benign FFPE thyroid specimens were analyzed from the BRAFV600E mutated and BRAFwt PTC groups, respectively.
The screening of BRAF mutations identified BRAFV600E in “atypical” cell foci from both groups of patients. “Unusual” BRAF substitutions were observed in histologically benign thyroid associated with BRAFV600E PTCs. These mutations were very uncommon in the group with BRAFwt PTCs and in BRAFV600E PTCs. Therefore, lesions carrying BRAF mutations may represent “abortive” attempts at cancer development: only BRAFV600E boosts neoplastic transformation to PTC.
BRAFV600E mutated “atypical foci” may represent precursor lesions of BRAFV600E mutated PTCs.
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Cesari, Valentina <1985>. « High sensitivity analysis of BRAF mutations in neoplastic and non-neoplastic thyroid lesions ». Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2014. http://amsdottorato.unibo.it/6360/.
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The clonal distribution of BRAFV600E in papillary thyroid carcinoma (PTC) has been recently debated. No information is currently available about precursor lesions of PTCs.
My first aim was to establish whether the BRAFV600E mutation occurs as a subclonal event in PTCs. My second aim was to screen BRAF mutations in histologically benign tissue of cases with BRAFV600E or BRAFwt PTCs in order to identify putative precursor lesions of PTCs. Highly sensitive semi-quantitative methods were used: Allele Specific LNA quantitative PCR (ASLNAqPCR) and 454 Next-Generation Sequencing (NGS).
For the first aim 155 consecutive formalin-fixed and paraffin-embedded (FFPE) specimens of PTCs were analyzed. The percentage of mutated cells obtained was normalized to the estimated number of neoplastic cells. Three groups of tumors were identified: a first had a percentage of BRAF mutated neoplastic cells > 80%; a second group showed a number of BRAF mutated neoplastic cells < 30%; a third group had a distribution of BRAFV600E between 30-80%. The large presence of BRAFV600E mutated neoplastic cell sub-populations suggests that BRAFV600E may be acquired early during tumorigenesis: therefore, BRAFV600E can be heterogeneously distributed in PTC.
For the second aim, two groups were studied: one consisted of 20 cases with BRAFV600E mutated PTC, the other of 9 BRAFwt PTCs. Seventy-five and 23 histologically benign FFPE thyroid specimens were analyzed from the BRAFV600E mutated and BRAFwt PTC groups, respectively.
The screening of BRAF mutations identified BRAFV600E in “atypical” cell foci from both groups of patients. “Unusual” BRAF substitutions were observed in histologically benign thyroid associated with BRAFV600E PTCs. These mutations were very uncommon in the group with BRAFwt PTCs and in BRAFV600E PTCs. Therefore, lesions carrying BRAF mutations may represent “abortive” attempts at cancer development: only BRAFV600E boosts neoplastic transformation to PTC.
BRAFV600E mutated “atypical foci” may represent precursor lesions of BRAFV600E mutated PTCs.
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Kanter-Lewensohn, Lena. « Tumor progression in melanocytic lesions : biological and diagnostic implications / ». Stockholm, 1999. http://diss.kib.ki.se/1999/91-628-3623-4/.
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Nicholson, J. « Predicting malignancy in pre-neoplastic lesions detected during screening for pancreatic cancer ». Thesis, University of Liverpool, 2017. http://livrepository.liverpool.ac.uk/3008012/.
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Background: Screening is offered to individuals who have an identified increased risk of pancreatic cancer. Such risks may be increased because of a family history or a known genetic mutation which has been shown to confer increased risk. Amongst those being screened intraductal papillary mucinous neoplasm (IPMN) of the pancreas are increasingly common entities being detected incidentally; their risk of malignancy can be as high as 85%. Consensus guidelines exist for the management of these lesions – the morbidity associated with pancreas resection is as high as 50%. We set out to identify a marker which could be used to identify those IPMN which should be resected and those which may be safely observed. Methods: Individuals were identified from the European Registry of Hereditary Pancreatitis and Familial Pancreatic Cancer (EUROPAC) or patients identified in Liverpool or Hedielberg with cystic lesions and/or pancreatic cancer. Cancer screening was performed by imaging and with molecular analysis (including mutation analysis of TP53) of pancreatic juice obtained by endoscopic retrograde cholangiopancreatography (ERCP). Matched tissue sections and frozen sections of pancreatic tissue from 73 patients who underwent resection for IPMN were assessed histologically and for mutations in TP53 status using a novel limiting dilution Next Generation Sequencing technique. Results were assessed relative to clinical outcomes. Results: Amongst those 29 individuals who were screened with ERCP, 11 had IPMN, 7 IPMN with cancer (IPMC) and 3 pancreatic ductal adenocarcinoma (PDAC). The remaining cases were benign neoplastic or inflammatory conditions. Kaplan-Meier survival analysis at 5 years found that the presence of p53 mutation in the tissue was a better prognostic marker of survival than the histological diagnosis alone (p=0.0152 vs. p=0.0819). Sensitivity and specificity of p53 mutation as a predictor of survival was calculated as 0.89 and 0.95 respectively. There was 100% correlation between the p53 mutational status of the resected tissue and the pancreatic juice obtained at ERCP. When ERCP was assessed as a method for screening, however, there was found to be an unacceptably high incidence of post-ERCP pancreatitis (PEP) 7 cases of PEP in 16 ERCPs (44%). This rate was shown to be significantly reduced to 15% (6/40) with the use of pancreatic stent and diclofenac, but the overall prevalence of PEP was 23.2% over 14 years. There were no cases of PEP amongst those individuals being screened because of hereditary pancreatitis. Of 27 IPMN cases with frozen tissue 23 individuals had TP53 mutations. Seven cases died of pancreatic cancer after resection. Kaplan-Meier survival analysis revealed that one mutation p.L264R predicted survival regardless of histology (p= < 0.0001). The mutation was present in 6 of the 7 cases who died and in none of those who survived to 5 years. Mutation specific PCR was used to validate results showing that p.L264R discriminated between survivors and IPMN cases who died of cancer (AUC = 0.79). Conclusions: IPMN continues to cause concern and uncertainty among those individuals being screened for cancer who are largely well and asymptomatic. The p.L264R mutation could be used to differentiate those IPMN which result in poor survival to facilitate potentially curative surgery. The mutation may be present in pancreatic juice which can be collected endoscopically as a screening tool. The use of prophylactic measures to reduce PEP may be considered sufficient to bring the risk of complications to an acceptable level when compared to the relative certainty of prognosis afforded by a positive test for p.L264R.
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Giannoudis, Athina. « Human papillomaviruses in squamous intraepithelial lesions of the cervix ». Thesis, University of Liverpool, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.250230.
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Al-Bakkal, Ghasaq H. « Human papillomavirus type 16 E6 gene expression in neoplastic oral lesions of immunosuppressed individuals ». Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape17/PQDD_0002/MQ35050.pdf.
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Al-Kana, Randah. « Immunocytochemical detection of estrogen receptors in human breast cancer and in non-neoplastic lesions ». Thesis, McGill University, 1988. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=61739.
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Keenan, Stephen J. « Quantitative analyses and classification of cervical intraepithelial neoplasia (CIN) using automated machine vision ». Thesis, Queen's University Belfast, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.368597.
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Scopelliti, Michele. « Nuova tecnica di autotrapianto di fegato in un modello sperimentale porcino con preservazione del graft in machine perfusion : applicazione clinica per neoplasie epatiche non resecabili tramite chirurgia convenzionale ». Doctoral thesis, Università degli studi di Padova, 2015. http://hdl.handle.net/11577/3424160.
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A NEW LIVER AUTOTRANSPLANTATION TECHNIQUE USING SUBNORMOTHERMIC MACHINE PERFUSION FOR ORGAN PRESERVATION IN A PORCINE MODEL: CLINICAL INDICATION FOR THE TREATMENT OF UNRESECTABLE HEPATIC LESIONS WITH CONVENTIONAL SURGERY
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Abstract
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BACKGROUND:
Hepatic resection is the gold standard of therapy for primary and secondary liver tumors, but few patients are eligible for this procedure because of the extent of their neoplasms. Improvements in surgical experience of liver transplantation (OLT), hepatic resection and preservation with sub-normothermic machine perfusion (MP) have prompted the development of a new model of large animal autotransplantation. This sperimental model allowed the clinical application of Ex situ ex vivo liver surgery to treat otherwise unresectable liver tumors. METHODS:
Landrace pigs were used in this experiment. After intubation, hepatectomy was performed according to the classic technique. The intrahepatic caval vein was replaced with a homologous tract of porcine thoracic aorta. The liver was perfused with hypothermic Celsior solution followed by MP at 20 °C with oxygenated Krebs solution. An hepatectomy was performed during the period of preservation, which lasted 120 minutes, then the liver was reimplanted into the same animal in a 90° counterclockwise rotated position. The anastomoses were performed in the classic sequence. Samples of intravascular fluid, blood and liver biopsies were obtained at the end of the period of preservation in MP and again at 1 and 3 hours after liver reperfusion to evaluate graft function and microscopic damage.
Then we report the clinical application of the model on 8 clinical cases described individually. After appropriate preoperative study and with the permission of the ethics committee, the patients underwent ex situ liver resection.
RESULTS:
All animals survived the procedure. The peak of aspartate aminotransferase was recorded 60 minutes after reperfusion and the peak of alanine aminotransferase and lactate dehydrogenase after 180 minutes. Histopathologic examination under the light microscope identified no necrosis or congestion. Intraoperative echo-color Doppler documented good patency of the anastomosis and normal venous drainage.
Among the patients who underwent surgical treatment the overall mortality during the mean follow-up of 493 days , was 25 % ( 12.5 % for sepsis and 12.5 % for recurrence of disease ) .
The 66.6 % of patients in life is alive and currently free of neoplastic disease , 33.3 % are alive with disease recurrence in chemotherapy and in good overall clinical condition .
CONCLUSION:
This system made it possible to perform hepatic resections and vascular reconstructions ex situ while preserving the organ with mechanical perfusion (ex vivo, ex situ surgery). Improving surgical techniques regarding autotransplantation and our understanding of ischemia-reperfusion damage may enable the development of interesting scenarios for aggressive surgical treatment (Ex situ, ex vivo liver surgery ) or radiochemotherapy options to treat primary and secondary liver tumors unsuitable for conventional in situ surgery.NUOVA TECNICA DI AUTOTRAPIANTO DI FEGATO IN UN MODELLO SPERIMENTALE PORCINO CON PRESERVAZIONE DEL GRAFT IN MACHINE PERFUSION: APPLICAZIONE CLINICA PER NEOPLASIE EPATICHE NON RESECABILI TRAMITE CHIRURGIA CONVENZIONALE. !INTRODUZIONE : La resezione epatica rappresenta il gold standard per il trattamento dei tumori del fegato primitivi e secondari , tuttavia solo una minoranza di pazienti possono essere sottoposti a tale trattamento poichè spesso la diagnosi di neoplasia avviene in stadi di malattia neoplastica troppo avanzata. L’esperienza tecnica del nostro Centro legata alla chirurgia epatica resettiva e sostituitiva, associata ai nostri studi sul danno da ischemia-riperfusione e sull’allestimento di nuove metodiche di preservazione del graft tramite l’utilizzo della Machine Perfusion (MP), ci ha permesso di sviluppare un sistema di perfusione meccanica sub-normotermica per preservare il fegato, che consente di eseguire resezioni epatiche e complesse ricostruzioni vascolari ex-situ durante la perfusione meccanica (chirurgia ex-vivo, ex-situ). Questo modello sperimentale ha permesso l' applicazione clinica della chirurgia epatica ex vivo ex situ per il trattamento di tumori al fegato altrimenti non operabili . METODI : Per l’esecuzione dell’esperimento abbiamo utilizzato 5 maiali Landrace x Large White . Dopo l’ intubazione è stata eseguita l’ epatectomia secondo la tecnica classica . La vena cava intraepatica è stata sostituita con un omologo tratto di aorta toracica di suino. Il fegato è stato perfuso con soluzione di preservazione ipotermica (Celsior solution 60 mL/kg in aorta e 30 mL/kg in vena porta) a 4°C. Quindi il fegato veniva posto in un sistema di perfusione ossigenato e continuamente perfuso per 120 minuti con soluzione di Krebs (MP). Durante la preservazione in Machine Perfusion, veniva eseguita una epatectomia tramite dissezione a freddo con forbici. Dopo 120 minuti di preservazione in MP, il fegato veniva reimpiantato nello stesso animale (auto- trapianto) ruotato di 90° in senso antiorario. Le anastomosi sono state eseguite nella sequenza classica . Campioni sia di sangue che di liquido di preservazione venivano prelevati per determinare i livelli di AST, ALT, LDH e lattati dopo il termine del periodo di preservazione con MP e nuovamente a un ora e a tre ore dalla riperfusione epatica. Di seguito viene descritta l'applicazione clinica di questo modello sperimentale su 8 casi clinici descritti individualmente . Dopo adeguato studio preoperatorio e con il permesso del comitato etico , i pazienti sono stati sottoposti a resezione epatica ex situ. RISULTATI: Tutti gli animali sono sopravvissuti alla procedura . Il picco di aspartato aminotransferasi è stato registrato 60 minuti dopo la riperfusione e il picco di alanina aminotransferasi e lattico deidrogenasi dopo 180 minuti. L’indagine istopatologica alla microscopia ottica non ha documentato reperti significativi di necrosi e congestione all’analisi dei preparati esaminati. L’Eco color Doppler intraoperatorio ha documentato buona pervietà delle anastomosi e normale drenaggio venoso . Tra i pazienti sottoposti a trattamento chirurgico la mortalità globale su un follow-up medio di 493 giorni , è stata del 25 % ( 12,5 % per sepsi e 12,5% per recidiva di malattia ) . Il 66,6 % dei pazienti in vita è vivo e attualmente libero da malattia , il 33,3 % sono vivi con recidiva di malattia in trattamento chemioterapico. ! CONCLUSIONI : Questo modello sperimentale ha consentito di effettuare resezioni epatiche e ricostruzioni vascolari ex situ preservando l'organo con la perfusione meccanica ( chirurgia ex vivo-ex situ ) . Il miglioramento delle tecniche chirurgiche relative all’autotrapianto e la miglior comprensione del danno da ischemia-riperfusione potrebbe rendere possibile lo sviluppo di scenari interessanti per il trattamento di tumori epatici primitivi e secondari non suscettibili di trattamento chirurgico convenzionale.
Livres sur le sujet "Neoplastic lesion"
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Frith, C. H. Color atlas of neoplastic and non-neoplastic lesions in aging mice. Amsterdam : Elsevier, 1988.
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Frith, C. H. Incidence of neoplastic and nonneoplastic lesions in several strains of mice. Little Rock, AR : Toxicology Pathology Associates, 1987.
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Chevanne, Marta, et Riccardo Caldini. Immagini di Istopatologia. Florence : Firenze University Press, 2007. http://dx.doi.org/10.36253/978-88-5518-023-8.
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This collection of images of Histopathology is the fruit of the authors' thirty years' experience in the performance of practical exercises in General Pathology. It is aimed at students attending lessons of General Pathology on the Degree Courses in Medical Surgery and Biological Sciences. It does not aspire either to be complete from the point of view of the various organic pathologies, or to replace direct and personal observation of the histological preparations through the microscope, but is rather intended as an aid to students preparing for the exam. It does not include the rudiments of cytology and microscopic anatomy, which it is assumed have already been mastered by those approaching General Histopathology, nor are histopathological phenomena systematically addressed, for which the reader is referred to textbooks on General Pathology. The 44 preparations presented here have been grouped in line with the main arguments of General Pathology: Cellular Degeneration, Inflammation, Neoplasia both benign and malign, and Vascular Pathology. They have been selected for their didactic significance and the simplicity and clarity of the lesions present, without taking into account the information to be derived from the clinical case history. The images of the preparations, in which the best possible quality of reproduction has been sought, are presented in progressive enlargements and are accompanied by brief descriptions comprising the explanations essential for identification of the characteristic aspects of the elementary lesion, as well as any eventual defects in the preparations themselves. Effectively, the objective of the work is to enable the student to exercise his understanding of the images. For this reason the casuistics included is as essential as possible, and the method of presentation utilised is designed to avoid mere visual memorisation, stimulating first analysis and then synthesis, and the development of individual logical skills so as to indicate whether aspects of cellular pathology, inflammation or neoplasia are present.
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Konrad, Müller-Hermelink Hans, Neumann H. -G et Dekant W, dir. Risk and progression factors in carcinogenesis. Berlin : Springer, 1997.
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Laureno, Robert. Symmetry. Sous la direction de Robert Laureno. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190607166.003.0005.
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This chapter examines the causes of symmetric neurologic lesions in toxic and metabolic disease, trauma, neoplastic disease, vascular disease, and infectious disease. The importance of symmetry in diagnosis is emphasized. Symmetry can be a problem for the neurologist; especially on computed tomography (CT) scans, symmetric disease can be difficult to notice on the background of symmetric brain anatomy because the eye more quickly detects a one-sided lesion or multifocal asymmetric lesions than symmetric lesions. Symmetry of brain lesions is important to the clinician because it suggests a toxic, metabolic, or other chemically based cause. Diseases with symmetric pathology but unknown cause probably are chemically based; the clue of symmetry gives investigators an opportunity to pursue various avenues of research.
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Wheaton, Michael, Dustin Nowacek et Zachary London. Radiculopathy and Plexopathy. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199937837.003.0125.
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Disorders of the nerve roots and neural plexi present with pain, numbness, or weakness in the neck, back, or extremities. Although the history and physical examination provide essential diagnostic information, imaging and electrodiagnostic studies may further aid in localizing and characterizing the underlying lesion. Causes of radiculopathy include intervertebral disc herniation, spondylosis, spinal synovial cysts, infection, metastatic disease, hematoma, or infiltrative disease. The brachial and lumbosacral plexi are susceptible to trauma, structural anomalies, neoplastic infiltration, and inflammatory processes. Management of these disorders is directed at treating the underlying cause, alleviating pain, and focused physical rehabilitation.
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Neoplastic Lesions Of The Skin. Demos Medical Publishing, 2013.
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Plaza, José, et Victor Prieto. Neoplastic Lesions of the Skin. Springer Publishing Company, Incorporated, 2013.
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Plaza, José, Saul Suster et Victor G. Prieto. Demos Surgical Pathology Guides : Neoplastic Lesions of the Skin. Springer Publishing Company, Incorporated, 2013.
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Dean, Michael, et Karobi Moitra. Biology of Neoplasia. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780190238667.003.0002.
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The term “cancer” encompasses a large heterogeneous group of diseases that involve uncontrolled cell growth, division, and survival, culminating in local invasion and/or distant metastases. Cancer is fundamentally a genetic disease at the cellular level. Tumors occur because clones of abnormal cells acquire multiple lesions in DNA, nearly always involving mutations, chromosomal rearrangements, and extensive alteration of the epigenome. Up to 10% of cancers also involve inherited germline mutations that are moderately to highly penetrant. Cancers begin as localized growths or premalignant lesions that may regress or disappear spontaneously, or progress to a malignant primary tumor. The somatic changes that drive abnormal growth involve activating mutations of specific oncogenes, inactivation of tumor suppressor genes, and/or disruption of epigenetic controls. The latter can result from methylation or the modification of histones and other proteins that affect the remodeling of chromosomes. Numerous non-inherited factors can cause cancer by accelerating these events.
Chapitres de livres sur le sujet "Neoplastic lesion"
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Hellquist, Henrik, et Alena Skalova. « Non-neoplastic Lesions ». Dans Histopathology of the Salivary Glands, 23–65. Berlin, Heidelberg : Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-540-46915-5_2.
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Isidori, Andrea M., et Andrea Lenzi. « Neoplastic Intratesticular Lesions ». Dans Trends in Andrology and Sexual Medicine, 81–135. Cham : Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-51826-8_3.
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Sakr, Mahmoud F. « Neoplastic Lesions of the Tongue ». Dans Tongue Lesions, 139–65. Cham : Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-031-08198-9_10.
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Higashi, Reiji, Toshio Uraoka, Taku Sakamoto, Takahisa Matsuda, Takahiro Fujii, Takahiro Horimatsu, Yutaka Saito et al. « Atlas of Neoplastic Lesions ». Dans Atlas of Endoscopy with Narrow Band Imaging, 293–340. Tokyo : Springer Japan, 2015. http://dx.doi.org/10.1007/978-4-431-54243-8_16.
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Muto, Manabu, Haruhiro Inoue, Shuko Morita, Kuniko Monma, Tomonori Yano, Chikatoshi Katada, Kenichi Goda, Hisao Tajiri et Junko Fujiwara. « Atlas of Neoplastic Lesions ». Dans Atlas of Endoscopy with Narrow Band Imaging, 79–129. Tokyo : Springer Japan, 2015. http://dx.doi.org/10.1007/978-4-431-54243-8_6.
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Isidori, Andrea M., et Andrea Lenzi. « Non-neoplastic Intratesticular Lesions ». Dans Trends in Andrology and Sexual Medicine, 31–80. Cham : Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-51826-8_2.
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Schechter, Michal Yaela, Erik Van Laecke et Anne-Françoise Spinoit. « Neoplastic Lesions of Scrotum ». Dans Normal and Abnormal Scrotum, 341–74. Cham : Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-83305-3_24.
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Sakhuja, Puja, et K. P. Aravindan. « Neoplastic Lesions of Appendix ». Dans Surgical Pathology of the Gastrointestinal System, 895–921. Singapore : Springer Singapore, 2022. http://dx.doi.org/10.1007/978-981-16-6395-6_21.
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Yi, Eunhee S. « Non-neoplastic/Inflammatory Lesions in the Mediastinum ». Dans Mediastinal Lesions, 217–31. Cham : Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-48379-5_9.
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Pronin, Igor, et Valery Kornienko. « Congenital and Non-neoplastic Lesions ». Dans CT and MRI of Skull Base Lesions, 493–516. Cham : Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-65957-2_18.
Texte intégralActes de conférences sur le sujet "Neoplastic lesion"
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Duarte, Angelo Chelotti, Lucas Ghisleri, Isabella Colla Maia et Antônio Carlos Martins Maia Junior. « The role of image in the diagnosis of pseudotumor lesions : a pictorial essay ». Dans XIII Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1516-3180.743.
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Introduction: The clinical-radiological differentiation between neoplastic and pseudotumoral lesions has an important role in therapeutic approach, with repercussions on the conduct to be taken. When facing an expansive lesion, in addition to neoplasms, a list of differential diagnoses must be considered, including inflammatory, infectious, hemorrhagic lesions, among others. In this context, the role of imaging methods is highlighted in order to anticipate surgical management in the presumption of an aggressive neoplasm or, on the other hand, avoid an unnecessary invasive procedure. Objectives: To identify the warning signs of pseudotumor lesions in imaging studies. Methodology: Retrospective pictorial review of the archives of Diagnostic Imaging service of Santa Casa de São Paulo, between 2010 and 2020. Results: The warning signs that indicate a probable pseudotumoral lesion include spontaneous hypersignal in T1, marked hyposignal in T2, absence of significant expansive effect, cavitated lesion with high signal in diffusion, incomplete ring impregnation, restricted peripheral ring diffusion and spectral relations (choline / creatine) lower than 2. Each of these distinguishing features is discussed and exemplified. Conclusions: Although the distinction between expansive neoplastic and pseudotumoral lesions is not always direct, the systematic use of the exposed criteria allows greater assertiveness in the differential diagnosis. If the diagnostic doubt persists, therapeutic proof tests have a fundamental role in this context and, unfortunately, in some cases the final diagnosis will only be possible with biopsy.
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Morotomi, Emi, et Toshiyuki Tanaka. « Notice of Removal Automatic classification of neoplastic lesion on gastric biopsy images ». Dans 2015 54th Annual Conference of the Society of Instrument and Control Engineers of Japan (SICE). IEEE, 2015. http://dx.doi.org/10.1109/sice.2015.7285506.
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Cui, Changxu, Reika Takamatsu, Hiroshi Doguchi, Akiko Matsuzaki, Masanao Saio et Naoki Yoshimi. « Abstract 4416 : The pre-neoplastic lesion, mucin-depleted foci, reveals asde novohigh-grade dysplasia in rat colon carcinogenesis ». Dans Proceedings : AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012 ; Chicago, IL. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/1538-7445.am2012-4416.
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Moreno, Marcelo, Amauri de Oliveira, Tália Cássia Boff, Gabriela Nogueira Matschinski et Izadora Czarnobai. « SQUAMOUS CELL CARCINOMA METASTASIS OF THE MAMMARY GLAND : CASE REPORT ». Dans Scientifc papers of XXIII Brazilian Breast Congress - 2021. Mastology, 2021. http://dx.doi.org/10.29289/259453942021v31s1007.
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Introduction: Primary squamous cell carcinoma (SCC) of the breast is a rare neoplasm, which represents less than 0.1% of invasive breast cancers. Therefore, it is essential to discriminate between a primary SCC and a metastatic SCC. In order to be considered a primary carcinoma of the breast, a histological examination of the lesion must show more than 90% of squamous neoplastic cells, in addition to the absence of cutaneous SCC or other anatomical sites. Extra-mammary neoplasm metastases are uncommon, representing 0.5% to 2% of breast malignancies. Metastatic SCC in the mammary gland is an uncommon event. To date, only three cases were reported in the literature of secondary involvement of vulvar SCC in the mammary gland. The objective of this work is to report the case of a patient with secondary mammary metastasis to a vulva SCC. Case report: A 74-year-old female patient who underwent radical modified vulvectomy 10 years before. Her pathological stage was characterized as IIIB. For this reason, she was also submitted to adjuvant treatment with chemotherapy associated with radiotherapy to the vulvar region, inguinal lymph node chains and pelvic arteries. On the ninth year of cancer follow-up, she presented recurrence in the vaginal wall. In the complementary image exams, an extentension of neoplasia to pelvic organs was identified, but no distant metastatic lesions were found. She underwent monobloc resection of pelvic organs, with reconstruction of the urinary and intestinal transits. The patient showed a good clinical evolution, with no pelvic complaints. After one year, the patient returned complaining of a nodule in the right breast. On physical examination, a lesion was observed at the junction of the lateral quadrants of the breast, measuring +/- 3.5 cm, with associated inflammatory signs and imprecise limits, with a central region showing a fistulous orifice through which the necrotic material passed. On the mammography, a dense, rounded and partially delimited lesion was identified. She underwent a core biopsy that described a SCC. According to her clinical history, it was considered a remote relapse of the vulvar SCC. The patient was submitted to a quadrantectomy with an ipsilateral axillary lymphadenectomy and reconstruction with a lateral thoracic flap. On an anatomopathological examination there was a description that the neoplasm would invade the underlying muscle tissue; and the resection margins were free. Four out of the fourteen isolated axillary lymph nodes had metastases, without perinodal soft tissue invasion. Six months after breast surgery, the patient evolved metastases to both lungs and soon after she died without response to the systemic treatment employed. This report was approved by the Research Ethics – UFFS (Universidade Federal da Fronteira Sul) (number 4.034.565).
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Abreu, Thiago Martins de, Arthur Gomes Pidde, Pedro Henrique de Ávila Perillo, Silvaleide Ataides Assunção, Ianca Leandra Santos et Débora Sara de Almeida Cardoso. « DELAY IN THE DIAGNOSIS OF INVASIVE DUCTAL CARCINOMA DUE TO AN INFECTIOUS MASTITIS : CASE REPORT ». Dans Abstracts from the Brazilian Breast Cancer Symposium - BBCS 2021. Mastology, 2021. http://dx.doi.org/10.29289/259453942021v31s2067.
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Introduction: Breast cancer is the most common cause among women, with invasive ductal carcinoma (ICD) being the most prevalent and having great phenotypic and genotypic heterogeneity and the ability to metastasize. In turn, mastitis is an inflammation in the breast region, infectious or noninfectious causes, most commonly affecting lactating women. Objectives: It is intended to report a case of ICD accompanied by infectious mastitis and its reverberations. Case Report: A 27-year-old woman presents with a clinical history of mastitis in her left breast that occurred about 3 months ago after weaning her son. She also explained about the use of antibiotic therapy, multiple previous drainages, and local complication with engorgement, edema, erythema, and purulent drainage in the surgical ostium of the left breast. A new drainage and material collection was carried out. Computed tomography of the chest indicated a solid heterogeneous lesion, dense, irregular contours, with areas of air trapping, liquefaction, and cleavage plane with the left pectoralis major muscle and ipsilateral axillary adenomegaly. Pathological pathology confirmed the hypothesis of neoplasia, indicating grade III ICD in comedonecrosis. Immunohistochemistry demonstrated triple-negative character and culture, positivity for Corynebacterium renale. She started neoadjuvant chemotherapy with reduced breast volume and absence of secretion today. Discussion: This is a common and problematic situation in health systems. Repeated outpatient referrals, invasive processes without resolution, aggravating the patient’s case. Moreover, it is noted that mastitis has delayed the diagnosis of the neoplasm, which, depending on the delay, may result in a worse prognosis or a more aggressive or expensive treatment. Conclusion: The diagnostic investigation of neoplasms is of great importance in case of prolonged mastitis not responsive to treatment, due to the fact that many mastitides may come from neoplastic processes that generate the lesion, which can make this injured area conducive to bacterial proliferation.
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Oliveira, Persis Araújo, Juliana Campelo Aragão Bitencourt et Lorena Natali Cardoso Fernandes Caldas. « DIAGNOSTIC CHALLENGE OF A LOCALLY ADVANCED LESION : CASE REPORT OF PRIMARY BREAST ANGIOSARCOMA ». Dans Scientifc papers of XXIII Brazilian Breast Congress - 2021. Mastology, 2021. http://dx.doi.org/10.29289/259453942021v31s1082.
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Introduction: Primary angiosarcoma of the breast (PAOB) is a class of extremely rare sarcomas, with an incidence rate of 1/2,000 cases of breast cancer worldwide. It is more frequent in 20- and 50-year-old women without history of previous cancer and commonly described in the left breast. Clinical presentation can be the same as usual breast cancer and histology can mimic poorly differentiated ductal carcinoma, which is why immunohistochemistry should be performed. Swelling, a feeling of fullness and exponential growth within the breast are frequent complaints, as noted by Kunkiel et al. in their series of case reports. The natural history of PAOB is only partly understood, suggesting that the lesion begins within the mammary parenchyma and then infiltrates skin and subcutaneous tissue nearby. The predominant management has been mastectomy, mainly, or sectorectomy with clear margins in cases of conservative breast surgery. Adjuvant therapies are not associated with improved survival, except for adjuvant chemotherapy in localized tumors of 5 cm or more. Case report: S.O.S., a 32-year-old woman, identified breast asymmetry in 2017, during the lactation period, presence of mild pain and swelling in the left breast. She was admitted to the breast cancer and benign lesions outpatient clinic at Professor Alberto Antunes University Hospital in February 2019. She held a BI-RADS 4 breast magnetic resonance imaging (MRI) in January 2019, which suggestedan irregular mass in the left breast, probably of vasculolymphatic nature; also showed core biopsy in February 2019: low-grade PAOB. In April 2019, she underwent a modified radical mastectomy of the left breast with ipsilateral lymphadenectomy. Due to the large extent of the lesion, an entire cutaneous area of left anterior hemithorax was resected, and thoracoepigastric flap was used to close the left hemithorax. An anatomopathological report diagnosed PAOB grade I. In July 2019, immunohistochemistry corroborated the diagnosis of PAOB with CD31 positive; positive von Willebrand factor (Factor VIII - polyclonal Rabbit) and ki67 positive for 25% of neoplastic cells. In the fourth month after the surgery, the patient started adjuvant radiotherapy, concluding it in October 2019. In post-treatment follow-up, in January 2021, she was referred to the breast reconstruction program, awaiting the procedure until this report was made.
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Belluco, Rosana Zabulon Feijó, Melissa de Andrade Baqueiro, Vitória Vasconcelos de Lara Resende, Flávio Lúcio Vasconcelos et Jefferson Lessa Soares de Macedo. « EXTENSIVE DERMATOFIBROSARCOMA PROTUBERANS IN THE CHEST AND BREAST : A CASE REPORT ». Dans XXIV Congresso Brasileiro de Mastologia. Mastology, 2022. http://dx.doi.org/10.29289/259453942022v32s1033.
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Dermatofibrosarcoma protuberans (DP) is a neoplasm of the deep layer of the dermis and subcutaneous tissue. It presents a rare incidence and constitutes 0.1% of the malignant tumors. It has local aggressive behavior with slow tumor growth, low metastasis rates of around 5%, but has high rates of local recurrence after surgical excision. The diagnosis is histopathological through biopsy of the lesion, and the fluorescence in situ hybridization (FISH) method can help in selected cases by detecting possible chromosomal rearrangements in the tissue. Physical examination, magnetic resonance imaging, and computed tomography may be helpful in assessing the area of tumor extension. The treatment of choice is resections with 3-cm wide margins or Mohs micrographic surgery. The prognosis is directly related to the correct excision of the compromised margins. A woman, 51 years old, presented with a raised, brownish, irregular, 13×8 cm multinodular lesion attached to the overlying skin, in the epigastric region, which extended to the left hypochondrium and lower quadrants of the left breast, without local symptoms or lymph node enlargement. She reported the appearance of a small nodular skin lesion at the site 10 years ago and reports continuous growth of the nodule, with the involvement of the adjacent skin and the left breast starting 5 years ago, after the formation of a hypertrophic scar due to two previous local resections of the initial lesion. Mammography showed a nodule of cutaneous origin in the lower inner quadrant of the left breast, which may correspond to keloids — BIRADS 2. Breast ultrasound showed a solid, echogenic nodule measuring 1.6×1.2 cm in the left breast at 8 am; 2.5 cm from the nipple — suggestive of lipoma, and at 7 am, nodule measuring 2.4×1.6 cm that penetrates the breast parenchyma — BIRADS 3. The lesion was diagnosed as dermatofibrosarcoma on histopathological examination of a skin fragment. The patient underwent resection of the lesion with a safety margin by the mastology team and primary reconstruction using a thigh graft by the plastic surgery team. A surgical specimen was sent for anatomopathological examination that presented a result compatible with a previous biopsy, reiterating the diagnosis of DP, and with peripheral and deep surgical margins free of neoplastic involvement; evolved without postoperative complications or restriction of range of motion; and referred to radiotherapy to assess the need for additional treatment.
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Glanzmann, Thomas M., Pascal Uehlinger, Jean-Pierre Ballini, Alexandre Radu, Tanja Gabrecht, Philippe Monnier, Hubert van den Bergh et Georges Wagnières. « Time-Resolved Autofluorescence Spectroscopy of the Bronchial Mucosa for the Detection of Early Cancer : Clinical Results ». Dans European Conference on Biomedical Optics. Washington, D.C. : Optica Publishing Group, 2001. http://dx.doi.org/10.1364/ecbo.2001.4432_199.
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Time-resolved measurements of endogenous tissue autofluorescence were carried out on the bronchial mucosa of 18 patients during endoscopy by the means of an optical fibre-based spectrometer. The objective was to assess the fluorescence lifetime as a new contrast parameter between normal and malignant tissue and to explain the origin of a previously observed contrast in fluorescence intensity. The intra- and interpatient variation of tissue autofluorescence intensity and decay on normal tissue was determined, with the outcome that a strong fluctuation in autofluorescence intensity but not in lifetime was observed on the normal tissue. Preliminary results were obtained by comparing fluorescence decays on normal mucosa and dysplasia/carcinoma in situ. No significant change in fluorescence decay nor in spectrum between 510 and 650 nm was found. Measurements in parallel with an endoscopic autofluorescence imaging device, on the other hand, indicated a contrast in intensity and spectrum on the same lesions. This suggests that the spectral contrast might be due to an enhanced blood concentration in deeper-lying layers of the lesion to which the optical fibre-based contact measurements are less sensitive. The difference in intensity might be due to a lower concentration in fluorophores or to the thickening of the epithelium in the neoplastic mucous membrane. However, no indication of fluorescence quenching in the upper layers of the mucous membrane was found as the reason for the reduced fluorescence intensity. The fluorescence decays showed a quite stable behaviour with three decay times of 6.9 ns, 2.0 ns and 0.2 ns in the spectral range between 430 and 680 nm. This can be an indication that there is one dominant fluorophore involved, the calculated decay times suggest that it might be elastin. However, a slight spectral dependence of the fluorescence decays lead to the presumption that there is a contribution from other fluorophores, probably flavins and NADH.
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Gulhote, Daniela Alves, Gabriel Santaterra Barros, Mariana Suemi Sukessada, Ana Beatriz Barbosa Piffer, João Fernando Coclet Pio da Silva, Pedro Neves Fortunato, Danilo Takashi Yoshimatsu Ueno, Bruna Franchito Freire et Hilton Mariano da Silva Junior. « Painful ophthalmoplegia due to involvement of cavernous sinus region by malignant neoplasm : report of three cases ». Dans XIII Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1516-3180.621.
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Context: Intracranial tumor spread is an infrequent and late manifestation of head and neck cancers. We report three cases of painful ophthalmoplegia due to larynx and parotid neoplastic involvement. Data disclosure was authorized by the patients through an Informed Consent Form. Case reports: A 47-year-old man presents right retro- orbital pain and progressive ophthalmoplegia 5 months after resection of laryngeal spinocellular carcinoma and local radiotherapy. A 44-year-old man, 9 months after excision of spinocellular carcinoma of the larynx and subsequent radiotherapy, presents severe pain and paralysis of the left CN VI. Imaging exams showed involvement of CS. A 67-year-old woman with a tumoral mass in the left preauricular region. Biopsy revealed adenocarcinoma of the parotid gland. After total parotidectomy, the supra-omohyoid cervical ganglion was removed. Patient received radiotherapy for 3 months. Then, she presented a frontal and right temporal headache, more intense in the retro-orbital region. After one month, she developed complete CS syndrome, with the right CN VI being the first to be affected. MRI revealed an irregular enhancement lesion in right CS after contrast administration. All patients died despite treatment. Conclusions: In patients with painful ophthalmoplegia, the most common hypotheses are diabetic neuropathy and Tolosa-Hunt syndrome. CS involvement may be the first evidence of a distant head and neck disease. Despite the poor prognosis, palliative care should be considered.
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Camacho, Ana Thereza da Cunha Uchoa, Ana Paula Pontes Rodrigues, Maria Clara Sousa Peixoto, Rebeca de Sousa França et Lívia Nazaré Soares Silva. « RECURRENT PHYLLODES TUMOR MALIGNANCY : A CASE REPORT ». Dans XXIV Congresso Brasileiro de Mastologia. Mastology, 2022. http://dx.doi.org/10.29289/259453942022v32s1070.
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Fibroepithelial tumors of the breast are part of a heterogeneous group of biphasic neoplasms, which include common fibroadenomas (FA) and phyllodes tumors (PTs). The PT is a rare fibroepithelial tumor that is histologically divided into three grades: benign, malignant, or borderline. Although only about 10% of these tumors are malignant, even benign tumors are prone to local recurrence and can become very large in size. The standard management of PT is surgical excision with negative surgical margins, due to the propensity for local recurrence. Therefore, the report about this type of tumor with multiple recurrences and malignization in the same person is important for the literature. A female patient, 30 years old, without comorbidities, with an obstetrical history of an abortion due to anembryonic egg and with a previous oncological history of four left breast segmental resections for the removal of solid nodules, confirmed anatomopathologically as borderline PT, benign PT, FA, and benign PT, respectively, in the years 2017, 2018, 2018, and 2019, was observed. No intercurrences were noted in the follow-up with a mastologist who found, in the physical examination, the presence of nodules and a palpable left breast, which caused discomfort when lying in the left decubitus position, with painless, nonsecretive, without palpable lymph nodes, and with accelerated growth. Ultrasonography revealed the presence of simple cysts in the right breast and two solid nodules BI-RADS 4 compatible with the diagnostic hypothesis of PT; therefore, surgical resection was indicated. However, with the increase in the volume of the nodules, it was not possible to obtain free margins and a simple mastectomy was chosen. On November 11, 2021, a left mastectomy was performed with partial resection of the pectoralis major muscle due to an intraoperative infiltrative lesion and immediate breast reconstruction with the placement of silicone prosthesis, without complications. In the anatomopathological examination, a malignant PT was identified with an infiltrative border pattern and the presence of neoplastic infiltration in the underlying skeletal muscle tissue. On December 23, 2021, the oncologist informed that the CT-PET performed days before denoted the absence of sites suggestive of a neoplastic process and the presence of a probable inflammatory scarring process in the left breast around the breast prosthesis. She is currently being followed up by the mastologist and the oncologist, through imagining examinations together with the clinical consultation, without the use of chemotherapies.
Rapports d'organisations sur le sujet "Neoplastic lesion"
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Anderson, Marshall. Examination of Genetic Alterations in Preneoplastic and Neoplastic Lesions of the Lung From Uranium Miners. Final Technical Report. Office of Scientific and Technical Information (OSTI), juillet 2000. http://dx.doi.org/10.2172/763958.
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Ke, Youqiang, C. S. Foster et S. S. Forootan. Identification of Possible Molecular Markers to Predict the Malignant Tendency of the Prostate Intraepithelial Neoplasia (PIN) Lesions. Fort Belvoir, VA : Defense Technical Information Center, novembre 2005. http://dx.doi.org/10.21236/ada448496.
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