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Littérature scientifique sur le sujet « Nanoscale metal organic frameworks (nanoMOFs) »

Auteur : Grafiati

Publié le 25 janvier 2025

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Articles de revues sur le sujet "Nanoscale metal organic frameworks (nanoMOFs)"

Oggianu, Mariangela, Valentina Mameli, Noemi Monni, Suchithra Ashoka Sahadevan, Marco Sanna Angotzi, Carla Cannas et Maria Laura Mercuri. « Nanoscaled Metal-Organic Frameworks : Challenges Towards Biomedical Applications ». Journal of Nanoscience and Nanotechnology 21, n^o 5 (1 mai 2021) : 2922–29. http://dx.doi.org/10.1166/jnn.2021.19043.

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Achieving metal-organic frameworks (MOFs) in the form of nanoparticles (NanoMOFs) represents a recent challenge due to the possibility to combine the intrinsic porosity of these materials with the nanometric dimension, a fundamental requirement for strategic biomedical applications. In this outlook we envision the current/future opportunities of the NanoMOFs in the field of biomedicine, with particular emphasis on (i) biocompatible MOFs composition; (ii) MOFs miniaturization and (iii) nanoMOFs applications.

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Li, Xue, Marianna Porcino, Jingwen Qiu, Doru Constantin, Charlotte Martineau-Corcos et Ruxandra Gref. « Doxorubicin-Loaded Metal-Organic Frameworks Nanoparticles with Engineered Cyclodextrin Coatings : Insights on Drug Location by Solid State NMR Spectroscopy ». Nanomaterials 11, n^o 4 (8 avril 2021) : 945. http://dx.doi.org/10.3390/nano11040945.

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Recently developed, nanoscale metal-organic frameworks (nanoMOFs) functionalized with versatile coatings are drawing special attention in the nanomedicine field. Here we show the preparation of core–shell MIL-100(Al) nanoMOFs for the delivery of the anticancer drug doxorubicin (DOX). DOX was efficiently incorporated in the MOFs and was released in a progressive manner, depending on the initial loading. Besides, the coatings were made of biodegradable γ-cyclodextrin-citrate oligomers (CD-CO) with affinity for both DOX and the MOF cores. DOX was incorporated and released faster due to its affinity for the coating material. A set of complementary solid state nuclear magnetic resonance (ssNMR) experiments including 1H-1H and 13C-27Al two-dimensional NMR, was used to gain a deep understanding on the multiple interactions involved in the MIL-100(Al) core–shell system. To do so, 13C-labelled shells were synthesized. This study paves the way towards a methodology to assess the nanoMOF component localization at a molecular scale and to investigate the nanoMOF physicochemical properties, which play a main role on their biological applications.

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Christodoulou, Ioanna, Pengbo Lyu, Carla Vieira Soares, Gilles Patriarche, Christian Serre, Guillaume Maurin et Ruxandra Gref. « Nanoscale Iron-Based Metal–Organic Frameworks : Incorporation of Functionalized Drugs and Degradation in Biological Media ». International Journal of Molecular Sciences 24, n^o 4 (8 février 2023) : 3362. http://dx.doi.org/10.3390/ijms24043362.

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Metal–organic frameworks (MOFs) attract growing interest in biomedical applications. Among thousands of MOF structures, the mesoporous iron(III) carboxylate MIL-100(Fe) (MIL stands for the Materials of Lavoisier Institute) is among the most studied MOF nanocarrier, owing to its high porosity, biodegradability, and lack of toxicity. Nanosized MIL-100(Fe) particles (nanoMOFs) readily coordinate with drugs leading to unprecedented payloads and controlled release. Here, we show how the functional groups of the challenging anticancer drug prednisolone influence their interactions with the nanoMOFs and their release in various media. Molecular modeling enabled predicting the strength of interactions between prednisolone-bearing or not phosphate or sulfate moieties (PP and PS, respectively) and the oxo-trimer of MIL-100(Fe) as well as understanding the pore filling of MIL-100(Fe). Noticeably, PP showed the strongest interactions (drug loading up to 30 wt %, encapsulation efficiency > 98%) and slowed down the nanoMOFs’ degradation in simulated body fluid. This drug was shown to bind to the iron Lewis acid sites and was not displaced by other ions in the suspension media. On the contrary, PS was entrapped with lower efficiencies and was easily displaced by phosphates in the release media. Noticeably, the nanoMOFs maintained their size and faceted structures after drug loading and even after degradation in blood or serum after losing almost the totality of the constitutive trimesate ligands. Scanning electron microscopy with high annular dark field (STEM-HAADF) in conjunction with X-Ray energy-dispersive spectrometry (XEDS) was a powerful tool enabling the unraveling of the main elements to gain insights on the MOF structural evolution after drug loading and/or upon degradation.

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Oggianu, Mariangela, Noemi Monni, Valentina Mameli, Carla Cannas, Suchithra Ashoka Sahadevan et Maria Laura Mercuri. « Designing Magnetic NanoMOFs for Biomedicine : Current Trends and Applications ». Magnetochemistry 6, n^o 3 (1 septembre 2020) : 39. http://dx.doi.org/10.3390/magnetochemistry6030039.

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Metal–organic frameworks (MOFs) have shown a great potential in biomedicine due to their promising applications in different fields, including drug delivery, thermometry, theranostics etc. In this context, the development of magnetic sub-micrometric or nanometric MOFs through miniaturization approaches of magnetic MOFs up to the nanoscale still represents a crucial step to fabricate biomedical probes, especially in the field of theranostic nanomedicine. Miniaturization processes have to be properly designed to tailor the size and shape of particles and to retain magnetic properties and high porosity in the same material, fundamental prerequisites to develop smart nanocarriers integrating simultaneously therapeutic and contrast agents for targeted chemotherapy or other specific clinical use. An overview of current trends on the design of magnetic nanoMOFs in the field of biomedicine, with particular emphasis on theranostics and bioimaging, is herein envisioned.

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Luo, Jia, Michael Florian Peter Wagner, Nils Ulrich, Peter Kopold, Christina Trautmann et Maria Eugenia Toimil Molares. « (Digital Presentation) Electrochemical Conversion of Cu Nanowires Synthesized By Electrodeposition in Track-Etched Templates to HKUST-1 ». ECS Meeting Abstracts MA2022-02, n^o 23 (9 octobre 2022) : 977. http://dx.doi.org/10.1149/ma2022-0223977mtgabs.

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Metal-organic frameworks (MOFs) are a novel type of nanoporous materials that have attracted widespread attention over the past two decades [1]. Cu-based metal-organic frameworks such as Cu3(BTC)2 (also known as HKUST-1) are one of the most famous MOF representatives, which exhibit a huge open porosity and thus a remarkably capacity to store and uptake different gases [2, 3]. Recently, increasing efforts are devoted toward finding synthetic routes that enable downsizing MOF crystals to the nanoscale. Achieving control over the size and shape of nanoMOFs and finding ways to assemble them is essential for their exploitation in integrated devices such as sensors, gas separation membranes or photoelectrodes. In this study we explore the conversion of free-standing arrays Cu nanowires with controlled diameter and length synthesized by electrodeposition in etched ion-track membranes into HKUST-1. In a first process step, free-standing Cu wires are produced by dissolving the ion-track polymer template. In a second step, the wires are converted into HKUST-1 structures by electrochemical oxidation. Applying 2.5 V versus a Cu counter electrode, the Cu nanowires are oxidatively dissolved and the MOF is built up as the as-formed Cu2+ ions bind to the BTC3− ligands in the electrolyte solution. The morphology and crystallinity of the samples at different transformation stages is investigated by scanning electron microscopy (Fig. 1) and transmission electron microscopy, respectively. X-ray diffraction spectra measured at different conversion times reveal the appearance of the characteristic reflections of HKUST-1. These results will be compared with previous studies of the transformation of Cu nanowires to HKUST-1 nanowires inside the polymer membrane [4]. Figure 1: SEM images of cylindrical Cu nanowires (a) before and (b) during the electrochemical conversion process, and (c) of a representative octahedral particle after complete conversion to HKUST-1. References [1] Freund R, Canossa S, Cohen SM, Yan W, Deng et al. Angewandte Chemie International Edition. (2021) 2: 23946-23974 [2] Chui SS-Y, Lo SM-F, Charmant JP, Orpen AG, Williams ID. Science. (1999) 283:1148-50. [3] Li H, Li L, Lin R-B, Zhou W, Zhang Z, Xiang S, et al. EnergyChem. (2019) 1:100006. [4] Caddeo F, Vogt R, Weil D, Sigle W, Toimil-Molares ME, Maijenburg AW. ACS applied materials & interfaces . (2019)11:25378-87. Figure 1

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Hidalgo, T., M. Alonso-Nocelo, B. L. Bouzo, S. Reimondez-Troitiño, C. Abuin-Redondo, M. de la Fuente et P. Horcajada. « Biocompatible iron(iii) carboxylate metal–organic frameworks as promising RNA nanocarriers ». Nanoscale 12, n^o 8 (2020) : 4839–45. http://dx.doi.org/10.1039/c9nr08127e.

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Porcino, Marianna, Ioanna Christodoulou, Mai Dang Le Vuong, Ruxandra Gref et Charlotte Martineau-Corcos. « New insights on the supramolecular structure of highly porous core–shell drug nanocarriers using solid-state NMR spectroscopy ». RSC Advances 9, n^o 56 (2019) : 32472–75. http://dx.doi.org/10.1039/c9ra07383c.

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Cutrone, Li, Casas-Solvas, Menendez-Miranda, Qiu, Benkovics, Constantin et al. « Design of Engineered Cyclodextrin Derivatives for Spontaneous Coating of Highly Porous Metal-Organic Framework Nanoparticles in Aqueous Media ». Nanomaterials 9, n^o 8 (1 août 2019) : 1103. http://dx.doi.org/10.3390/nano9081103.

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Nanosized metal-organic frameworks (nanoMOFs) MIL-100(Fe) are highly porous and biodegradable materials that have emerged as promising drug nanocarriers. A challenging issue concerns their surface functionalization in order to evade the immune system and to provide molecular recognition ability, so that they can be used for specific targeting. A convenient method for their coating with tetraethylene glycol, polyethylene glycol, and mannose residues is reported herein. The method consists of the organic solvent-free self-assembly on the nanoMOFs of building blocks based on β-cyclodextrin facially derivatized with the referred functional moieties, and multiple phosphate groups to anchor to the nanoparticles’ surface. The coating of nanoMOFs with cyclodextrin phosphate without further functional groups led to a significant decrease of macrophage uptake, slightly improved by polyethylene glycol or mannose-containing cyclodextrin phosphate coating. More notably, nanoMOFs modified with tetraethylene glycol-containing cyclodextrin phosphate displayed the most efficient “stealth” effect. Mannose-coated nanoMOFs displayed a remarkably enhanced binding affinity towards a specific mannose receptor, such as Concanavalin A, due to the multivalent display of the monosaccharide, as well as reduced macrophage internalization. Coating with tetraethylente glycol of nanoMOFs after loading with doxorubicin is also described. Therefore, phosphorylated cyclodextrins offer a versatile platform to coat nanoMOFs in an organic solvent-free, one step manner, providing them with new biorecognition and/or “stealth” properties.

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Marshall, Checkers R., Emma E. Timmel, Sara A. Staudhammer et Carl K. Brozek. « Experimental evidence for a general model of modulated MOF nanoparticle growth ». Chemical Science 11, n^o 42 (2020) : 11539–47. http://dx.doi.org/10.1039/d0sc04845c.

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Zhang, Xuanjun, Mohamed Ali Ballem, Zhang-Jun Hu, Peder Bergman et Kajsa Uvdal. « Nanoscale Light-Harvesting Metal-Organic Frameworks ». Angewandte Chemie International Edition 50, n^o 25 (9 mai 2011) : 5729–33. http://dx.doi.org/10.1002/anie.201007277.

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Thèses sur le sujet "Nanoscale metal organic frameworks (nanoMOFs)"

Ding, Mengli. « Synthesis and drug delivery applications of iron(III) trimesate nanoMOFs ». Electronic Thesis or Diss., université Paris-Saclay, 2024. http://www.theses.fr/2024UPASF095.

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Les matériaux hybrides organiques-inorganiques à l'échelle nanométrique (nanoMOFs) ont montré un potentiel significatif dans le domaine de la libération contrôlée de médicaments (DDS) en raison de leurs propriétés avantageuses, notamment des compositions modulables, une porosité importante, de grandes surfaces spécifiques, de bonnes biocompatibilités et dégradabilités. Parmi la famille de nanoMOFs, le MIL-100(Fe) (MIL signifie Matériaux de l'Institut Lavoisier), construit à partir de trimères de fer et de ligands organiques (trimésate), a été largement étudié, avec des données bien documentées sur la toxicité in vivo et la biocompatibilité, ce qui en fait un candidat très attractif pour des applications biomédicales. Nous avons rédigé deux articles de synthèse qui détaillent la synthèse et les applications des nanoMOFs dans le domaine biomédical. Ce travail nous a permis de cerner plusieurs défis qui subsistent encore dans l'application biomédicale et la production à grande échelle des nanoMOFs MIL-100(Fe). Tout d'abord, il est essentiel d'améliorer la stabilité des nanoMOFs pendant leur conservation et dans de milieux biologiques, en vue d'une utilisation industrielle ultérieure. De plus, les méthodes de synthèse des nanoMOFs MIL-100(Fe) nécessitent une optimisation pour répondre aux exigences de la production à grande échelle non consommatrice d'énergie et “verte” (sans solvants organiques toxiques). Pour tenter de pallier à ces problèmes, nous proposons la modification de la surface des nanoMOFs MIL-100(Fe) avec des copolymères ou oligomères biocompatibles afin d'améliorer leur stabilité et leur biocompatibilité in vitro/in vivo. En outre, nous avons optimisé la stratégie de synthèse des nanoMOFs à base de trimésate de fer pour permettre une production simple, écologique, continue, respectueuse de l'environnement et à faible consommation d'énergie. Tout d'abord, nous avons conçu et synthétisé une famille de copolymères de type peigne qui comportent des chaines de poly(éthylène glycol) (PEG), des fonctions alendronate pour permettre un bon anchrage aux MOFs, et des molécules fluorescentes afin de permettre une bonne détection des nanoparticules composites. L'association de ces matériaux est extrêmement rapide (10 secondes) et les rendements avoisinent les 100%. Tous les composants des copolymères peigne jouent un role dans ce processus efficace de recouvrement. Les MIL-100(Fe) revêtus de copolymères ont non seulement démontré une excellente stabilité, mais aussi un caractère “furtif” évitant la reconnaissance par les macrophages. Les nanoMOFs ont été obtenus par une synthèse micro-onde usuelle, mais nécessitant un grand apport d'énergie et des températures élevées (130 °C). Dans un effort d'optimiser la synthèse, nous avons exploré des méthodes nouvelles opérant à température ambiante. Tout d'abord nous avons utilisé des modulateurs afin de contrôler la taille des nanoMOFs à température ambiante. En faisant varier les rapports molaires (R) de l'acide acétique (modulateur) et de l'acide trimésique (ligand organique), nous avons obtenu des nanoMOFs avec des diamètres hydrodynamiques allant de 40 à 200 nm. Nous avons ensuite recouvert ces nanoparticules avec des oligomères à base de cyclodextrine, afin d'obtenir une bonne stabilité sans compromettre leur capacité d'encapsulation de molécules actives. Ces études proposent des méthodes vertes et ouvrent la voie à la production à grande échelle des nanoMOFs à base de trimésate de fer
Nanoscale metal-organic frameworks (nanoMOFs) have shown significant promise as drug delivery systems (DDS) due to their advantageous properties, including tunable compositions, uniform porosity, large surface areas, biocompatibility, and degradability. Among these, MIL-100(Fe) (MIL stands for Materials of the Lavoisier Institute) nanoMOFs, constructed from trimesate organic linkers and iron trimers, have been extensively studied. We reviewed here in detail their well-documented in vivo toxicity and biocompatibility data, making them highly attractive candidates for drug delivery applications. We highlighted several challenges which remain in the biomedical application and large-scale production of MIL-100(Fe) nanoMOFs. First, improving the storage stability of MIL-100(Fe) is essential for further use. Additionally, the synthesis methods for MIL-100(Fe) nanoMOFs need optimization to meet the demands of green (organic solvent free) large-scale production. To address these issues, we propose the surface modification of MIL-100(Fe) nanoMOFs with biocompatible copolymers or oligomers to enhance their stability and biocompatibility. Furthermore, we have investigated novel synthesis strategies for MIL-100(Fe) nanoMOFs to enable simple, green, environmentally friendly, and low-energy production. We designed and synthesized a family of comb-like copolymers, comprising grafted: i) “x” (0-6) alendronate (Ale) anchoring units; ii) “y” (up to 45) poly(ethylene glycol) (PEG) side chains with molecular weight of zK (z=0.5, 2, 5), and iii) fluorescent Alexa Fluor (F) moieties. The resulting FAlexPEGzKy copolymers spontaneoulsy adsorbed onto the nanoMOF's surface in aqueous media, reaching ~100% efficiency. We highlighted the cooperative effects of each component of the FAlexPEGzKy copolymers in the association process. The coating occurred in the top layers without affecting the nanoMOF's crystallinity. The composition of the FAlexPEGzKy copolymers was optimized to ensure a good stability in biological media, despite the non covalent nature of the coating. In addition, the copolymer-coated MIL-100(Fe) nanoMOFs not only exhibited excellent storage stability but also demonstrated a “stealth effect” in macrophage J774 cells, as shown by confocal studies and iron quantification in the cells. In these studies, MIL-100(Fe) nanoMOFs were prepared by a conventional microwave hydrothermal procedure at high temperature (130 °C). To optimize the process, we investigated the possibilities to obtain MIL-100(Fe) nanoMOFs at room temperature. We used modulators in an attempt to control the size of the nanoMOFs. By varying the molar ratio (R) of acetic acid (modulator) to trimesic acid (organic linker), we obtained MIL-100(Fe) nanoMOFs with hydrodynamic diameters ranging from 40 to 200 nm. However, the resulting MIL-100(Fe) nanoMOFs needed also to be coated to avoid their aggregation. The coatings based on crosslinked cyclodextrins did not compromise the drug-loading capacity of the nanoMOFs. In a nutshell, this work presents novel strategies to construct nanoMOFs in a lego-type manner, using materials prepared mostly using “green” chemistry

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Taylor, Kathryn Michelle Louise Lin Wenbin. « Development of nanoscale metal-organic frameworks and hybrid silica nanoparticles for biomedical applications ». Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2009. http://dc.lib.unc.edu/u?/etd,2291.

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Thesis (Ph. D.)--University of North Carolina at Chapel Hill, 2009.
Title from electronic title page (viewed Jun. 26, 2009). "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department of Chemistry." Discipline: Chemistry; Department/School: Chemistry.

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Carné, Sánchez Arnau. « A new synthetic method for nanoscale metal-organic frameworks and their application as contrast agents for magnetic resonance imaging ». Doctoral thesis, Universitat Autònoma de Barcelona, 2014. http://hdl.handle.net/10803/283409.

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La present Tesis ha estat dedicada a la síntesis de materials Metal·lorgànics a la nanoescala (NMOFs, fent servir l’acrònim anglès) i l’estudi de les seves potencials aplicacions com a Agents de Contrast (AC) en Imatgeria per Ressonància Magnètica. En conseqüència, dos línies de treball es distingeixen al llarg de la lectura d’aquesta Tesis: (ii) el desenvolupament de una nova metodologia per a sintetitzar NMOFs, i (ii) la síntesis de nous NMOFs que puguin complir els requeriments específics per tal de ser utilitzats com a AC. En el primer capítol, revisem la evolució que ha viscut el camp dels MOFs, des de els seus antecedents que van fer possible el seu descobriment fins a les seves aplicacions actuals i les seves noves perspectives. Prestem especial atenció a les actuals metodologies emprades per a sintetitzar NMOFs, i al adveniment de noves aplicacions aparegudes gràcies a la seva mida nanoscòpica. El en Capítol 3 descrivim la validació de la tècnica coneguda com Spray-Drying (SD) com a nova metodologia per sintetitzar NMOFs i les superestructures buides que se’n deriven. S’estudia l’impacte dels principals paràmetres experimentals en la síntesi del NMOFs així com les diferents modalitats de usatge que ofereix la tècnica. Precisament, la versatilitat de la tècnica ens ha permès sintetitzar un ampli ventall de NMOFs pertanyent a les subfamílies més representatives. El Capítol 4 explica les possibilitats de utilitzar la tècnica de SD per a combinar NMOFs amb altres especies funcionals per tal de sintetitzar compòsits basats en MOFs. Demostrem com les superestructures buides de NMOFs poden ser utilitzades per a encapsular diferents materials, tals com cristalls de NaCl, molècules fluorescents i nanopartícules magnètiques. A més, també demostrem com cristalls de NMOFs poden ser fàcilment encapsulats en matrius polimèriques mitjançant la tècnica de SD. La varietat de compòsits basats en MOFs que es pot obtenir utilitzant la tècnica de SD permet ampliar el ventall d’aplicacions dels NMOFs. En el capítol 5 es descriu la segona línia de treball que conforma la present Tesis doctoral referent a la síntesis de una nova generació de NMOFs amb propietats de AC. La estratègia consisteix en utilitzar lligands heterocíclics emprats en la síntesis dels AC moleculars, els quals presenten una gran afinitat per als ions de Gd(III). El lligand heterocíclic DOTP s’utilitza per l’assemblatge de un MOF bimetàl·lic i porós. Aquest MOF és miniaturitzat a la nanoescala per a forma dispersions col·loïdals estables; és estable en medi fisiològic, en cultiu cel·lular i no presenta citotoxicitat. A més, presenta unes propietats de AC interessants, com ho demostra la relaxativitat mesurada a camp magnètic alt (r1 = 5 mM-1·s-1 a 500 MHz) i una relaxativitat màxima a 40 MHz de 15 mM-1·s-1, la qual es manté constant al llarg de un ampli ventall de pH.
The present Thesis has been dedicated to the synthesis of nanoscale Metal-Organic Frameworks (NMOFs) and the study of their potential application as Contrast Agents (CAs). Accordingly, two main lines of work can be distinguished through the lecture of this Thesis: i) the development of a novel synthetic methodology to synthesise NMOFs; and ii) the synthesis of new NMOFs that meet the specific requirements for their use as CAs. In the first Chapter, we review the evolution of the field of MOFs, from their antecedents that made their discovery possible to their current applications and prospects. We pay special attention to the current methodologies to synthesise MOFs at the nanoscale, and the advent of new applications resulting from their small size. Chapter 3 describes the validation of the Spray-Drying (SD) technique as a new methodology to synthesise NMOFs and their related hollow superstructures. The impact of the main experimental parameters on the synthesis of NMOFs is given as well as the different modes of operations that the SD technique offers for their synthesis. The versatility of the technique has allowed us to synthesise a wide panel of NMOFs belonging to the most representative subfamilies. In Chapter 4 the possibilities of combining NMOFs with other functional species using the SD technique to synthesise MOF-based composites is explained. We show how the MOF-based hollow superstructures can be used to encapsulate different materials, including NaCl crystals, dyes and FeOx inorganic nanoparticles (INPs). Furthermore, we also prove that NMOFs can also be easily encapsulated within functional matrices, such as polymers, by SD. Finally, we demonstrate that the unique capabilities of the SD to create MOF-based composites can be exploited to further expand the applications of NMOFs. In the second axis of this Thesis, Chapter 5 describes the synthesis of a new generation of NMOFs with CA properties. The strategy consists on using heterocyclic ligands currently employed in the synthesis of molecular CAs, which possess high chelating capabilities towards Gd(III) ions. The macrocyclic ligand DOTP is used to assemble a porous, heterometallic MOF. This MOF is miniaturizable down to the nanoscale to form stable colloids; is stable in physiological saline solution and cell culture media; and is not cytotoxic. It shows interesting relaxometric properties with a r1 at high field (500 MHz) of 5 mM-1·s-1 and a maximum in r1 of 15 mM-1·s-1 at 40 MHz, which remains constant over a wide pH range and increases with temperature.

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Pham, Minh-Hao. « Nanoscale Metal—Organic Frameworks : Synthesis and Application of Bimodal Micro/Meso-Structure and Nanocrystals with Controlled Size and Shape ». Thesis, Université Laval, 2013. http://www.theses.ulaval.ca/2013/30124/30124.pdf.

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Les composés à réseau moléculaire organo-métalliques (MOFs) ont émergé comme de nouvelles classes de matériaux hybrides organo-inorganiques avec des potentialités significatives en séparation, stockage de gaz, catalyse et support de médicaments. Ces matériaux sont formés par un processus d’assemblage dans lequel les ions métalliques sont liés entre eux via un ligand organique, ce qui génère une surface de l’ordre de 6500 m2g−1 et des volumes de pores supérieurs à 4.3 cm3g−1. Dans cette thèse trois différentes approches ont été développées pour la synthèse des nanocristaux MOFs à deux modes micro-mésoporeux, ainsi que des nanocristaux MOFs à taille et forme contrôlable. En plus, ces nanocristaux MOFs ont été utilisé comme un agent structurant pour la synthèse de nanocomposite hybride platine-oxyde de titane (metal-oxide-TiO2-PtOx) qui ont été utilisé comme photocatalyseurs pour la production d’hydrogène à partir de l’eau sous la lumière visible. Dans ce travail: (i) La première approche implique une méthode utilisant un surfactant, suivi de traitement solvo-thermale en présence d’acide acétique pour former des nanocristaux MOFs micro-mésoporeux. L’utilisation de surfactant non-ionique tell que F127 (EO97PO69EO97) pour induire une structure mésoporeuse provoque labilité de la cristallisation du mur des pores de la structure MOF. Tandis que la présence de l’acide acétique contrôle la vitesse de cristallisation du réseau MOFs pour former une mésostructure bien définie à l’intérieur des nanocristaux MOFs. En utilisant cette approche des nanocristaux de [Cu3(BTC)2] et [Cu2(HBTB)2] de structure mésoporeuse avec des diamètres de pores autour de 4.0 nm et des micropores intrinsèques ont été synthétisés. (ii) La méthodologie de modulation de la coordination a été développée pour contrôler la forme et la taille des nanocristaux MOFs. Des nanocubes et nanofeuilles de [Cu2(ndc)2(dabco)]n de la structure MOFs ont été synthétisés en utilisant simultanément l’acide acétique et la pyridine ou la pyridine uniquement, respectivement comme modulateurs sélectifs. Ces nanocristaux MOFs possèdent une cristallinité élevée et une grande capacité d’adsorption. La morphologie a été aussi étudiée en fonction de la capacité d’adsorption de CO2. (iii) La synthèse hydrothermale en contrôlant la taille de nanocristaux de carboxylates de structure MOFs, en utilisant simultanément des réactifs stabilisants et des réactifs contrôlant la déprotonation a été démontrée. Dans le cas de Fe-MIL-88B-NH2, la molécule triblock copolymer a été utilisée comme un réactif stabilisant en coordonnant avec le métal et contrôlant la croissance en formant des nanocristaux. L’acide acétique joue le rôle comme un agent déprotonant des liants carboxyliques en variant sa concentration dans le milieu réactionnel, ainsi il régule la vitesse de nucléation, conduisant à aussi contrôler la taille ainsi que le rapport longueur/largeur des nanocristaux. (iv) Finalement, des nanocomposites hybrides Fe2O3-TiO2-PtOx de forme creuse possédant l’activité photocatalytique performante ont été développés en utilisant des nanocristaux Fe-MIL-88B composés de centres Fe3(μ3-O) liés par coordination insaturée comme template solide. Ce type de nanocomposites non seulement absorbe la lumière visible mais aussi améliore la séparation des électrons et des trous photo-générés, due à l’épaisseur de paroi mince et les deux co-catalyseurs (Fe2O3 and PtOx) localisés sur deux opposites surfaces du creux. En conséquence, l'efficacité en photocatalyse de ce type de nanocomposites est élevée pour la production d'H2 à partir de l'eau sous la lumière visible.
Metal-organic frameworks (MOFs) have emerged as an important new class of porous inorganic-organic hybrid solids with the potential for a significant impact on separation, gas storage, catalysis and biomedicine. These materials are formed by assembly process in which metal ions are linked together by rigid organic ligands, which creates enormous surface areas (up to 6500 m2g−1) and high pore volumes (up to 4.3 cm3g−1). In this thesis, three different synthetic approaches have been developed to achieve bimodal micro/mesoporous MOF nanocrystals as well as nanosized MOFs with controlled size and shape. In addition, using the synthesized MOF nanocrystals as templates, a new hollow hybrid metal-oxide-TiO2-PtOx nanocomposite has also been prepared, and used as the visible-light driven photocatalyst for the hydrogen production from water. In this work, (i) the first approach involves nonionic surfactant-templated solvothermal synthesis in the presence of acetic acid toward hierarchically micro-mesoporous MOF nanocrystals. The use of a nonionic surfactant such as F127 (EO97PO69EO97) as mesostructure template induces the ability to crystallize a MOF structure of pore wall, while the presence of acetic acid allows control of the crystallization rate of the framework to form well-defined mesostructures within the crystalline MOF nanocrystals. Using this approach, [Cu3(BTC)2] and [Cu2(HBTB)2]-based MOF nanocrystals containing mesopores with diameter around 4.0 nm and intrinsic micropores have been successfully synthesized. (ii) Secondly, the coordination modulation methodology has been developed to control shape and size of MOF crystals at the nanoscale. Nanocubes and nanosheets of [Cu2(ndc)2(dabco)]n MOF have been rationally synthesized by using simultaneously acetic acid and pyridine or only pyridine, respectively, as selective modulators. These MOF nanocrystals exhibit high crystallinity and high CO2 sorption capacity. Their morphology-dependent CO2 sorption property has also been demonstrated. (iii) Thirdly, the size-controlled hydrothermal synthesis of uniform carboxylate-based MOF nanocrystals using simultaneously stabilizing reagent and deprotonation-controlled reagent has been demonstrated. In case of Fe-MIL-88B-NH2, the molecular triblock copolymers as stabilizing reagents coordinate with the metal ions and thus stabilize nuclei, which suppress the crystal growth to form nanocrystals. Acetic acid as deprotonation-controlled reagent adjusts the deprotonation of the carboxylic linker via varying its concentration in the reaction mixture, and thus regulates the rate of nucleation, leading to tailoring the size and aspect ratio (length/width) of the nanocrystals. (iv) Finally, a new hollow hybrid metal-oxide-TiO2-PtOx nanocomposite as an efficient photocatalyst has been developed by using iron-based MIL-88B nanocrystals consisting of coordinatively unsaturated Fe3(μ3-O) clusters as template. The hollow nanocomposite not only absorbs visible light, but also enhances the separation between photogenerated electrons and holes because of its thin wall and the surface separation of two distinct functional cocatalysts (Fe2O3 and PtOx) on two different surface sides of the hollow. As a result, the efficient photoactivity of the nanocomposite photocatalysts has been found for the H2 production from water under visible light irradiation.

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Chapitres de livres sur le sujet "Nanoscale metal organic frameworks (nanoMOFs)"

Zhang, Zhonghao, et Zhiping Zheng. « Nanostructured and/or Nanoscale Lanthanide Metal-Organic Frameworks ». Dans Lanthanide Metal-Organic Frameworks, 297–367. Berlin, Heidelberg : Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/430_2014_167.

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Pant, Parul, Aadya Jaipuria et Chetna Gupta. « Spectroscopic and Microscopic Techniques : Tools for Characterizing Nanoscale Metal–Organic Frameworks (NMOFs) ». Dans Metal-Organic Frameworks (MOFs) as Catalysts, 127–64. Singapore : Springer Singapore, 2022. http://dx.doi.org/10.1007/978-981-16-7959-9_5.

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Lian, Xiang, Chuxiao Xiong et Jian Tian. « Chapter 7. Nanoscale Porphyrinic Metal–Organic Frameworks for Photodynamic Therapy ». Dans Porphyrin-based Supramolecular Architectures, 256–83. Cambridge : Royal Society of Chemistry, 2021. http://dx.doi.org/10.1039/9781839164934-00256.

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Schukraft, Giulia, et Camille Petit. « Green Synthesis and Engineering Applications of Metal–Organic Frameworks ». Dans Sustainable Nanoscale Engineering, 139–62. Elsevier, 2020. http://dx.doi.org/10.1016/b978-0-12-814681-1.00006-0.

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Hoang, Tran, et Shengqian Ma. « Biomedical Applications of Nanoscale Metal- Organic Frameworks ». Dans Hybrid Nanomaterials, 334–54. CRC Press, 2017. http://dx.doi.org/10.1201/9781315370934-13.

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Sharma, Bhagwati, Tridib K. Sarma et Anish Khan. « Application of Nanoscale Metal-Organic Frameworks for Phototherapy of Cancer ». Dans Metal-Organic Framework Nanocomposites, 213–36. CRC Press, 2020. http://dx.doi.org/10.1201/9780429346262-8.

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Sajid, Muhammad, et Ihsanullah. « Toxicity of nanoscale metal-organic frameworks in biological systems ». Dans Metal-Organic Frameworks for Biomedical Applications, 383–95. Elsevier, 2020. http://dx.doi.org/10.1016/b978-0-12-816984-1.00019-6.

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Safari, Meysam. « Application of Metal-Organic Frameworks for the Extraction ». Dans Recent Trends in the Application of Metal-Organic Frameworks [Working Title]. IntechOpen, 2024. http://dx.doi.org/10.5772/intechopen.114193.

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Metal-organic frameworks are materials with a lot of potential in various analytical applications, particularly in preparing samples due to their varied structure topology, good thermostability, high surface area, permanent nanoscale porosity, and adjustable pore size. However, their chemical and thermal stabilities are currently a significant limitation in the field of extraction. These materials derived from metal-organic frameworks have demonstrated good extraction performance when it comes to environmental pollutants. In this chapter, we provide a critical overview of the applications of metal-organic frameworks for the extraction, such as stir bar solid extraction, micro-solid-phase extraction, solid-phase microextraction, magnetic solid-phase extraction, and solid-phase extraction.

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Abbasi, Zahra, Levente Cseri, Xiwang Zhang, Bradley P. Ladewig et Huanting Wang. « Metal–Organic Frameworks (MOFs) and MOF-Derived Porous Carbon Materials for Sustainable Adsorptive Wastewater Treatment ». Dans Sustainable Nanoscale Engineering, 163–94. Elsevier, 2020. http://dx.doi.org/10.1016/b978-0-12-814681-1.00007-2.

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Mittal, Ashi, Indrajit Roy et Sona Gandhi. « Drug Delivery Applications of Metal-Organic Frameworks (MOFs) ». Dans Drug Carriers [Working Title]. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.103684.

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There has been substantial progress in the field of metal–organic frameworks (MOFs) and their nanoscale counterparts (NMOFs), in recent years. Their exceptional physicochemical properties are being constantly and actively exploited for various applications such as energy harvesting, gas storage, gas separation, catalysis, etc. Due to their porous framework, large surface area, tunability and easy surface functionalization, MOFs and NMOFs have also emerged as useful tools for biomedical applications, specifically for drug delivery. As drug carriers, they offer high drug loading capacity and controlled release at the target site. This chapter aims to give a panorama of the use of these MOFs as drug delivery agents. A brief overview of the structure and composition of MOFs, along with various methods and techniques to synthesize NMOFs suitable for drug delivery applications are mentioned. In addition, the most commonly employed strategies to associate drugs with these NMOFs are highlighted and methods to characterize them are also briefly discussed. The last section summarizes the applications of MOFs and NMOFs as carriers of therapeutic drugs, biomolecules, and other active agents.

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Actes de conférences sur le sujet "Nanoscale metal organic frameworks (nanoMOFs)"

Bediaga, Harbil, Maitane Urgoiti, Arantzazu Letona et Celia Elicegui. « On Nanoscale Metal-Organic Frameworks for Therapeutic, Imaging, and Sensing Applications ». Dans MOL2NET'21, Conference on Molecular, Biomedical & Computational Sciences and Engineering, 7th ed. Basel, Switzerland : MDPI, 2021. http://dx.doi.org/10.3390/mol2net-07-09259.

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Lin, Wenbin. « Nanoscale metal-organic frameworks for photodynamic therapy and cancer immunotherapy (Conference Presentation) ». Dans Optical Methods for Tumor Treatment and Detection : Mechanisms and Techniques in Photodynamic Therapy XXVI, sous la direction de David H. Kessel et Tayyaba Hasan. SPIE, 2017. http://dx.doi.org/10.1117/12.2261217.

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Gupta, Vandana, A. K. Paul et Sachin Tyagi. « Synthesis & ; characterization of iron-carboxylate nanoscale metal organic frameworks for drug delivery ». Dans 2015 2nd International Symposium on Physics and Technology of Sensors (ISPTS). IEEE, 2015. http://dx.doi.org/10.1109/ispts.2015.7220125.

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Yu, Pei, Zehang Zhuang, Guihua Qiu, Haolin Chen, Yuying Zhao, Jinxiang Chen et Xiqiang Liu. « Abstract 2190 : Theranostical nanoscale metal-organic frameworks-mediated rapid multiplexed microRNA detection and highly therapeutic efficacy in living oral cancer cells ». Dans Proceedings : AACR Annual Meeting 2017 ; April 1-5, 2017 ; Washington, DC. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.am2017-2190.

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