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Littérature scientifique sur le sujet « Nanoparticles, folic acid, camptothecin, Hela »

Auteur : Grafiati

Publié le 9 mars 2023

Mis à jour le 10 mars 2023

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Articles de revues sur le sujet "Nanoparticles, folic acid, camptothecin, Hela"

Ancira-Cortez, Alejandra, Enrique Morales-Avila, Blanca E. Ocampo-García, Carlos González-Romero, Luis A. Medina, Gustavo López-Téllez et Erick Cuevas-Yáñez. « Preparation and Characterization of a Tumor-Targeting Dual-Image System Based on Iron Oxide Nanoparticles Functionalized with Folic Acid and Rhodamine ». Journal of Nanomaterials 2017 (2017) : 1–11. http://dx.doi.org/10.1155/2017/5184167.

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Cancer is one of the diseases with most deaths worldwide, around 8.2 million annually. For this reason, several treatments and diagnostic tools have been investigated and developed over the past decades. Among them, a dual-image system has been developed to achieve and enhance the detection of cancer, which has not been done with systems currently available. The present study describes the preparation of a dual-image targeting system composed of magnetic iron oxide nanoparticles functionalized with folic acid and rhodamine; nanoparticles synthesis was achieved by a coprecipitation method; the functionalization was carried out by a carbodiimide with folic acid and/or the rhodamine isothiocyanate; conjugates were characterized by spectrometric techniques; toxicity was measured by cell proliferation assay on HeLa cells using progressive concentrations of functionalized nanoparticles. Cellular uptake assay was carried out by competitive assay on HeLa cells. Iron oxide magnetite nanoparticles, modified with folic acid and rhodamine, were successfully synthetized with a particle size lower than 20 nm (TEM), EDS, HRTEM, and XDR showed highly crystalline Fe3O4 nanoparticles. Folic acid and rhodamine were conjugated with high efficiency. A significant selectivity and uptake, facilitated by surface modification of iron oxide nanoparticles with folic acid, were demonstrated. The multifunctional system showed suitable physicochemical and biological properties for cell targeting through folate receptors.

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Guerrero-Florez, Valentina, Stelia C. Mendez-Sanchez, Olga A. Patrón-Soberano, Vicente Rodríguez-González, Diana Blach et Fernando Martínez O. « Gold nanoparticle-mediated generation of reactive oxygen species during plasmonic photothermal therapy : a comparative study for different particle sizes, shapes, and surface conjugations ». Journal of Materials Chemistry B 8, n^o 14 (2020) : 2862–75. http://dx.doi.org/10.1039/d0tb00240b.

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Xia, Yu, Tiantian Xu, Mingqi Zhao, Liang Hua, Yi Chen, Changbing Wang, Ying Tang et Bing Zhu. « Delivery of Doxorubicin for Human Cervical Carcinoma Targeting Therapy by Folic Acid-Modified Selenium Nanoparticles ». International Journal of Molecular Sciences 19, n^o 11 (13 novembre 2018) : 3582. http://dx.doi.org/10.3390/ijms19113582.

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Cancer-specific drug delivery represents an attractive approach to preventing undesirable side effects and increasing the accumulation of the drug in tumors. The surface modification of selenium nanoparticles (SeNPs) with targeting moieties thus represents an effective strategy for cancer therapy. In this study, SeNPs were modified with folic acid (FA), whose receptors were overexpressed on the surface of cancer cells, including human cervical carcinoma HeLa cells, to fabricate tumor-targeting delivery carrier FA-SeNPs nanoparticles. Then, the anticancer drug doxorubicin (DOX) was loaded onto the surface of the FA-SeNPs for improving the antitumor efficacy of DOX in human cervical carcinoma therapy. The chemical structure characterization of FA-Se@DOX showed that DOX was successfully loaded to the surface of FA-SeNPs to prepare FA-Se@DOX nanoparticles. FA-Se@DOX exhibited significant cellular uptake in human cervical carcinoma HeLa cells (folate receptor overexpressing cells) in comparison with lung cancer A549 cells (folate receptor deficiency cells), and entered HeLa cells mainly by the clathrin-mediated endocytosis pathway. Compared to free DOX or Se@DOX at the equivalent dose of DOX, FA-Se@DOX showed obvious activity to inhibit HeLa cells’ proliferation and induce the apoptosis of HeLa cells. More importantly, FA-Se@DOX could specifically accumulate in the tumor site, which contributed to the significant antitumor efficacy of FA-Se@DOX in vivo. Taken together, FA-Se@DOX may be one novel promising drug candidate for human cervical carcinoma therapy.

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Xuan, Guangshan, Min Zhang, Yang Chen, Shan Huang et Imshik Lee. « Design and Characterization of a Cancer-Targeted Drug Co-Delivery System Composed of Liposomes and Selenium Nanoparticles ». Journal of Nanoscience and Nanotechnology 20, n^o 9 (1 septembre 2020) : 5295–304. http://dx.doi.org/10.1166/jnn.2020.17882.

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A drug co-delivery system composed of selenium nanoparticles (SeNPs) has attracted increasing interest due to its ability to increase the anticancer efficacy against multidrug-resistant cancer cells. In this study, a cancer-targeted drug co-delivery system combining fluorescein-loaded liposomes and SeNPs was designed and evaluated. The system was developed by coating SeNPs and fluorescein-loaded liposomes with folic acid-chitosan conjugates (FA-CS-SeNPs-Lips). Folic acid-chitosan conjugates (FA-CS) were synthesized by coupling folic acid (FA) with chitosan (CS), and the structure was confirmed by performing Fourier transform spectroscopy (FT-IR) and nuclear magnetic resonance (1H-NMR) spectroscopy. Dynamic light scattering (DLS) measurements and transmission electron microscopy (TEM) were used to evaluate the particle size, Zeta potential, and morphology. The cytotoxicity of SeNPs coated with FA-CS conjugates (FA-CS-SeNPs) toward A549 cells and HeLa cells was examined using the MTT assay. The cancer-targeting ability and drug release behaviors were evaluated in vitro by measuring the cellular uptake of fluorescein and dialysis, respectively. The FA-CS-SeNPs were uniform, spherical particles with a ~50 nm diameter and high positive Zeta potential (+57.7 mV). Based on the results of the MTT assay, FA-CS-SeNPs displayed a more significant increase in the anticancer efficacy in HeLa cells than CS-SeNPs. FA-CS-SeNPs-Lips not only slowly released fluorescein but also specifically targeted HeLa cells through selective binding between folate and folate receptors to increase the cellular uptake of fluorescein.

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Zhou, Yu, Yanming Han, Gaiyun Li, Sheng Yang, Fuquan Xiong et Fuxiang Chu. « Preparation of Targeted Lignin–Based Hollow Nanoparticles for the Delivery of Doxorubicin ». Nanomaterials 9, n^o 2 (2 février 2019) : 188. http://dx.doi.org/10.3390/nano9020188.

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Due to their exceptional absorption capacity, biodegradability, and non-toxicity, nanoparticles (NPs) from lignin have emerged as vehicles for inorganic particles and drug molecules. However, the method for preparing targeted lignin particles is still complex and lacks sufficient research. Herein, a succinct strategy was proposed for the preparation of targeted lignin-based drug delivery NPs to load Doxorubicin Hydrochloride (DOX). The lignin hollow NPs (LHNPs) were used as a platform for the preparation of targeted delivery material by incorporating magnetic NPs and folic acid (FA) via layer-by-layer self-assembling. The results showed that the surface of LHNPs was covered uniformly by Fe3O4 NPs and grafted with folic acid. The folic-magnetic-functionalized lignin hollow NPs (FA-MLHNPs) could respond to magnetic field and folic acid receptors. In addition, the targeting performance of the FA-MLHNPs increased the cellular uptake of NPs in the case of HeLa cells. This research not only supported the modified NPs platform as a highly efficient nano-delivery method but also provided a facile approach to utilize renewable lignin biomaterials.

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Zu, Yuangang, Dan Wang, Xiuhua Zhao, Ru Jiang, Qi Zhang, Dongmei Zhao, Yong Li, Baishi Zu et Zhiqiang Sun. « A Novel Preparation Method for Camptothecin (CPT) Loaded Folic Acid Conjugated Dextran Tumor-Targeted Nanoparticles ». International Journal of Molecular Sciences 12, n^o 7 (28 juin 2011) : 4237–49. http://dx.doi.org/10.3390/ijms12074237.

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Erdem, M., S. Yalcin et U. Gunduz. « Folic acid-conjugated polyethylene glycol-coated magnetic nanoparticles for doxorubicin delivery in cancer chemotherapy : Preparation, characterization and cytotoxicity on HeLa cell line ». Human & ; Experimental Toxicology 36, n^o 8 (10 octobre 2016) : 833–45. http://dx.doi.org/10.1177/0960327116672910.

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Conventional chemotherapy is the most valid method to cope with cancer; however, it has serious drawbacks such as decrease in production of blood cells or inflammation of the lining of the digestive tract. These side effects occur since generally the drugs used in chemotherapy are distributed evenly within the body of the patient and cannot distinguish the cancer cells from the healthy ones. In this study, folic acid (FA)-conjugated, polyethylene-coated magnetic nanoparticles (FA-MNPs), and doxorubicin (Dox)-loaded formulation (Dox-FA-MNPs) were prepared. The cytotoxicity of these nanoparticles on HeLa and Dox-resistant HeLa cells was investigated. Magnetic nanoparticles (MNPs), polyethylene glycol (PEG)-coated MNPs (PEG-MNPs), and FA-MNPs were successfully synthesized and characterized by several methods. Dox loading of FA-MNPs and release profile of Dox from the nanoparticles were studied. Cytotoxic effects of FA-MNPs and Dox-FA-MNPs on HeLa cells were analyzed. MNPs, PEG-MNPs, and FA-MNPs all had small sizes and supermagnetic behavior. High amounts of Dox could be loded onto the nanoparticles (290 μgmL−1). In 24 h, 15.7% of Dox was released from the Dox-FA-MNPs. The release was increased in acidic conditions (pH 4.1). Internalization studies showed that FA-MNPs and Dox-FA-MNPs were taken up efficiently by HeLa cells. The investigation of cytotoxicity of the particles indicated that 38–500 μgmL−1 Dox-FA-MNPs significantly decreased the proliferation of HeLa cells compared to FA-MNPs. Due to their size, magnetic properties, internalization, drug release, and cytotoxicity characteristics, the MNPs prepared in this study may have potential application as a drug delivery system in cancer chemotherapy.

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Zheng, Xiawen, Yuejian Chen, Zhiming Wang, Lina Song, Yu Zhang, Ning Gu et Fei Xiong. « Preparation and In Vitro Cellular Uptake Assessment of Multifunctional Rubik-Like Magnetic Nano-Assemblies ». Journal of Nanoscience and Nanotechnology 19, n^o 6 (1 juin 2019) : 3301–9. http://dx.doi.org/10.1166/jnn.2019.16129.

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Through self-assembly of nanoparticles into high-order and stable structures of cubic clusters, high drug-loading rubik-like magnetic nano-assemblies (MNAs), possessing folic acid targeting and strong magnetism-enhanced cellular uptake capabilities, were built. In this study, the core of the cubic drug assemblies consisted of four monodisperse superparamagnetic iron oxide nanoparticles coated with layers of oleic acid (Fe3O4@OA), simultaneously encapsulating fluorescein, and Paclitaxol (Flu-MNAs and PTX-MNAs) for imaging and therapeutic applications. To enable preferential tumor cellular uptake by the nanocarriers, the outermost layer of Fe3O4 was functionalized with the new dual-oleic acid-polyethylene glycol-folic acid polymer (FA-PEG-Lys-OA2) as a “shell.” The drug carriers exhibited excellent stability and biocompatibility, and showed high drug loading and excellent magnetic response In Vitro. Furthermore, preliminary evaluations of the drug carriers with Hela cells showed effective cellular targeting capability. In addition, the cubic assemblies enhanced anticancer efficiency for Hela cells compared to bare drugs. Especially, the applied external magnetic field further improved the uptake of the vectors, and thereby enhanced the inhibitory effect. In brief, all these results suggested that cubic assemblies could serve as potential strategies for targeted anticancer therapies.

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Liu, Min-Chao, Bing Liu, Xian-Li Chen, Hui-Chao Lin, Xiang-Yu Sun, Jia-Zheng Lu, Yan-Yu Li, Si-Qi Yan, Lu-Yong Zhang et Ping Zhao. « Calcium carbonate end-capped, folate-mediated Fe3O4@mSiO2 core-shell nanocarriers as targeted controlled-release drug delivery system ». Journal of Biomaterials Applications 32, n^o 8 (22 janvier 2018) : 1090–104. http://dx.doi.org/10.1177/0885328217752994.

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Magnetic mesoporous silica nanospheres (MMSN) were prepared and the surface was modified with cancer cell-specific ligand folic acid. Calcium carbonate was then employed as acid-activated gatekeepers to cap the mesopores of the MMSN, namely, MMSN-FA-CaCO3. The formation of the MMSN-FA-CaCO3 was proved by several characterization techniques, viz. transmission electron microscopy, zeta potential measurement, Fourier transform infrared spectroscopy, BET surface area measurement, and UV–Vis spectroscopy. Daunomycin was successfully loaded in the MMSN-FA-CaCO3 and the system exhibited sensitive pH stimuli-responsive release characteristics under blood or tumor microenvironment. Cellular uptake by folate receptor (FR)-overexpressing HeLa cells of the MMSN-FA-CaCO3 was higher than that by non-folated-conjugated ones. Intracellular-uptake studies revealed preferential uptake of these nanoparticles into FR-positive [FR(+)] HeLa than FR-negative [FR(-)]A549 cell lines. DAPI stain experiment showed high apoptotic rate of MMSN-FA-DNM-CaCO3 to HeLa cells. The present data suggest that the CaCO3 coating and folic acid modification of MMSN are able to create a targeted, pH-sensitive template for drug delivery system with application in cancer therapy.

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Sun, Lining, Zuwu Wei, Haige Chen, Jinliang Liu, Jianjian Guo, Ming Cao, Tieqiao Wen et Liyi Shi. « Folic acid-functionalized up-conversion nanoparticles : toxicity studies in vivo and in vitro and targeted imaging applications ». Nanoscale 6, n^o 15 (2014) : 8878–83. http://dx.doi.org/10.1039/c4nr02312a.

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Three kinds of folate-targeted up-conversion nanoparticle imaging agents were prepared. These nanoparticles show good biocompatibility and up-conversion luminescence emission in water, and low cytotoxicity in vivo and in vitro. They were successfully applied to the targeted imaging of HeLa cells.

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Thèses sur le sujet "Nanoparticles, folic acid, camptothecin, Hela"

GALBIATI, ALICE. « Different functionalization approaches to target micro and nano vectors toward tumor cells ». Doctoral thesis, Università degli Studi di Milano-Bicocca, 2012. http://hdl.handle.net/10281/160910.

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Micro and nanoparticles have been recently exploited to tackle two important points in medicine namely: drug specific targeting and gene therapy. The thesis covered both aspects although concentrating a large part of my work on the first one. In detail as far as the drug specific targeting is concerned, I have used the strategy of folic acid functionalization using as micro and nano-carriers poly-vinyl alcohol microcapsules (PVA-MCs) or organically modified silica nanoparticles (ORMOSILs). PVA-MCs show high versatility, biocompatibility (Cavalieri et al, 2006) and a threedimensional water soluble network able to adsorbs different chemical compounds. In my thesis I have studied the delivery of camptothecin (CPT), a powerful and insoluble antineoplastic drug, adsorbed on PVA-MC. The microparticles have been functionalized with folic acid using two different linking procedures. In one case a chitosan-folate complex has been produced and then linked on MC surface. Chitosan has been used as spacer arm to allow a varied three-dimensional orientation of the folate group. In the other case MCs have been functionalized with lysine, that is then used to link folate. The systems, tested for localization and viability on epithelial tumor cell lines and on a healthy connective line, have been shown to display a strong preference for the tumor cells. The strategy of folate mediated active targeting has been also applied to a system of silica-based nanoemulsion (ORMOSIL). The resulting ORMOSIL-FA has been tested for the FR-mediated localization in tumor cell lines, showing that the internalization process is not totally determined by FR. As far as gene therapy is concerned I have explored the possibility to use chitosan as biocompatible carrier for plasmid DNA. Chitosan is a natural, biocompatible polymer that can interact with nucleic acids to form a transfectable nanoparticle. Aim of my work has been to clarify the suitability of some already known chitosan derivatives in macrophages transfection.

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