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Littérature scientifique sur le sujet « N6-Isopentenyladenosine »

Auteur : Grafiati

Publié le 10 mars 2023

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Articles de revues sur le sujet "N6-Isopentenyladenosine"

Fiore, Donatella, Chiara Piscopo, Maria Proto, Michele Vasaturo, Fabrizio Dal Piaz, Bruno Fusco, Cristina Pagano, Chiara Laezza, Maurizio Bifulco et Patrizia Gazzerro. « N6-Isopentenyladenosine Inhibits Colorectal Cancer and Improves Sensitivity to 5-Fluorouracil Targeting FBXW7 Tumor Suppressor ». Cancers 11, n^o 10 (28 septembre 2019) : 1456. http://dx.doi.org/10.3390/cancers11101456.

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N6-isopentenyladenosine has been shown to exert potent in vitro antitumor activity on different human cancers, including colorectal cancer. Although some potential biochemical targets have been identified, its precise mechanism of action remains unclear. We found that N6-isopentenyladenosine affects colorectal cancer proliferation in in vitro models carrying different mutational status of FBXW7 and TP53 genes, and in HCT116 xenografts in SCID mice, by increasing the expression of the well-established tumor suppressor FBXW7, a component of the SCF-E3 ubiquitin ligase complex that promotes degradation of various oncoproteins and transcription factors, such as c-Myc, SREBP and Mcl1. Corroborating our previous studies, we identified for the first time the FBXW7/SREBP/FDPS axis as a target of the compound. Pull down of ubiquitinated proteins, immunoprecipitation and luciferase assays, reveal that through the increase of FBXW7/c-Myc binding, N6-isopentenyladenosine induces the ubiquitination of c-Myc, inhibiting its transcriptional activity. Moreover, in FBXW7- and TP53-wild type cells, N6-isopentenyladenosine strongly synergizes with 5-Fluorouracil to inhibit colon cancer growth in vitro. Our results provide novel insights into the molecular mechanism of N6-isopentenyladenosine, revealing its multi-targeting antitumor action, in vitro and in vivo. Restoring of FBXW7 tumor-suppressor represents a valid therapeutic tool, enabling N6-isopentenyladenosine as optimizable compound for patient-personalized therapies in colorectal cancer.

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HASHIZUME, Takeshi, Wataru TANIGUCHI et Tamiji SUGIYAMA. « Mass spectrometric determination of N6-isopentenyladenosine and N6-isopentenyladenine from human urine. » Analytical Sciences 2, n^o 2 (1986) : 157–59. http://dx.doi.org/10.2116/analsci.2.157.

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Colombo, Francesca, F. Stefania Falvella, Loris De Cecco, Monica Tortoreto, Graziella Pratesi, Pierangela Ciuffreda, Roberta Ottria et al. « Pharmacogenomics and analogues of the antitumour agent N6-isopentenyladenosine ». International Journal of Cancer 124, n^o 9 (1 mai 2009) : 2179–85. http://dx.doi.org/10.1002/ijc.24168.

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Chmur, Magdalena, Andrzej Bajguz et Alicja Piotrowska-Niczyporuk. « Effect of Cadmium on the Level of Isoprenoid-Derived Phytohormones in Duckweed Wolffia arrhiza ». Journal of Plant Growth Regulation 39, n^o 4 (28 mai 2020) : 1518–30. http://dx.doi.org/10.1007/s00344-020-10154-9.

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AbstractWolffia arrhiza (L.) Horkel ex Wimm. is an aquatic plant belonging to the Lemnaceae family. It does not have leaves, stems, and roots, flowers rarely occur, while body size can reach 1 mm of width and 1.3 mm of length. The present study demonstrates the endogenous level of isoprenoid-derived phytohormones and their changes under the influence of different cadmium (Cd) concentrations (0.1, 1, 10, and 100 µM). A liquid chromatography quadrupole-time-of-flight mass spectrometry analysis indicated the presence of abscisic acid, eight brassinosteroids (6-deoxocastasterone, 6-deoxotyphasterol, cathasterone, typhasterol, castasterone, 24-epicastasterone, brassinolide, and 28-homobrassinolide), seven free bases of cytokinins [trans-zeatin (tZ), cis-zeatin (cZ), dihydrozeatin (DHZ), N6-isopentenyladenine, N6-isopentenyladenosine, ortho-topolin, and meta-topolin], eight conjugates of cytokinins (tZ riboside, tZ-9-glucoside, tZ-7-glucoside, tZ-O-glucoside riboside, cZ-9-glucoside, DHZ riboside, DHZ-O-glucoside, and N6-isopentenyladenosine-7-glucoside) and gibberellic acid (GA3) in this duckweed. The level of phytohormones in plants treated with Cd has changed, e.g., the ABA level increased while GA3 decreased. Whereas the amount of BRs and CKs was different in Cd dose-dependent manner. Besides, it is worth noting that the distribution of 25 various phytohormones in the Wolffia arrhiza is reported for the first time.

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Dassano, Alice, Mariateresa Mancuso, Paola Giardullo, Loris De Cecco, Pierangela Ciuffreda, Enzo Santaniello, Anna Saran, Tommaso A. Dragani et Francesca Colombo. « N6-isopentenyladenosine and analogs activate the NRF2-mediated antioxidant response ». Redox Biology 2 (2014) : 580–89. http://dx.doi.org/10.1016/j.redox.2014.03.001.

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Bifulco, Maurizio, Anna Malfitano, Maria Proto, Antonietta Santoro, Maria Caruso et Chiara Laezza. « Biological and Pharmacological Roles of N6-Isopentenyladenosine : An Emerging Anticancer Drug ». Anti-Cancer Agents in Medicinal Chemistry 8, n^o 2 (1 février 2008) : 200–204. http://dx.doi.org/10.2174/187152008783497028.

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Kierzek, Elżbieta, et Ryszard Kierzek. « Influence of N6-isopentenyladenosine (i6A) on thermal stability of RNA duplexes ». Biophysical Chemistry 91, n^o 2 (juillet 2001) : 135–40. http://dx.doi.org/10.1016/s0301-4622(01)00165-x.

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Rajabi, Mehdi, Jamshid Mehrzad, Elena Gorincioi et Enzo Santaniello. « Antiproliferative Activity of N6-Isopentenyladenosine on HCT-15 Colon Carcinoma Cell Line ». Nucleic Acid Therapeutics 21, n^o 5 (octobre 2011) : 355–58. http://dx.doi.org/10.1089/nat.2011.0314.

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Spinola, Monica, Francesca Colombo, F. Stefania Falvella et Tommaso A. Dragani. « N6-isopentenyladenosine : A potential therapeutic agent for a variety of epithelial cancers ». International Journal of Cancer 120, n^o 12 (2007) : 2744–48. http://dx.doi.org/10.1002/ijc.22601.

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Laezza, Chiara, Angelo Migliaro, Rosalba Cerbone, Idolo Tedesco, Mariarosaria Santillo, Corrado Garbi et Maurizio Bifulco. « N6-Isopentenyladenosine Affects cAMP-Dependent Microfilament Organization in FRTL-5 Thyroid Cells ». Experimental Cell Research 234, n^o 1 (juillet 1997) : 178–82. http://dx.doi.org/10.1006/excr.1997.3610.

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Thèses sur le sujet "N6-Isopentenyladenosine"

Picardi, Paola. « Novel Insights into the Biological Effects of the Isoprenoid Derivative N6-Isopentenyladenosine : Involvement of the Metabolic Sensor Ampk in Angiogenesis Inhibition ». Doctoral thesis, Universita degli studi di Salerno, 2014. http://hdl.handle.net/10556/1477.

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2012 - 2013
N6-isopentenyladenosine (iPA) is a modified adenosine characterized by an isopentenyl chain derived by dimethylallyl pyrophosphate (DMAPP), an intermediate of the metabolic pathway of mevalonate, that is known to be deregulated in cancer. iPA is an endogenous isoprenoid-derived product present in mammalian cells as a free nucleoside in the cytoplasm, or in a tRNA-bound form, displaying well established pleiotropic biological effects, including a direct anti-tumor activity against several cancers. However, the precise mechanism of action of iPA in inhibiting cancer cell proliferation remains to be clarified. In this work, we investigated whether iPA could directly interfere with the angiogenic process, fundamental to cancer growth and progression, and if the growth and proliferation of human melanoma cells, known for their highly angiogenic phenotype, could be affected by the treatment with iPA. Finally, we investigated if iPA could have an immunomodulatory role targeting directly human natural killer (NK) cells, components of innate immunity that participate in immunity against neoplastic cells, in order to provide a cooperative and multifactorial mode of action of iPA to arrest cancer growth. To evaluate the potential involvement of iPA in angiogenesis, we employed human umbilical vein endothelial cells (HUVECs) as a suitable in vitro model of angiogenesis, by evaluating the viability, proliferation, migration, invasion, tube formation, and molecular mechanisms involved. Data were corroborated in mice by using a gel plug assay. iPA dose- and time-dependently inhibited all the neoangiogenesis stages, with an IC50 of 0.98 μM. We demonstrated for the first time that iPA was monophosphorylated into iPA 5'-monophosphate (iPAMP) by adenosine kinase (ADK) inside the cells. iPAMP is the active form that inhibits angiogenesis through the direct activation of AMP-kinase (AMPK). Indeed, all effects were completely reversed by pre-treatment with 5-iodotubercidin (5-Itu), an ADK inhibitor. The isoprenoid intermediate isopentenyl pyrophosphate (IPP), which shares the isopentenyl moiety with iPA, was ineffective in the inhibition of angiogenesis, thus showing that the iPA structure is specific for the observed effects. Thus, iPA is a novel AMPK activator and could represent a useful tool for the treatment of diseases where excessive neoangiogenesis is the underlying pathology... [edited by author]
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Rajabi, M. « ANTIPROLIFERATIVE ACTIVITY OF CYTOKININE DERIVATIVESAGAINST HCT-15 COLON AND MCF-7 BREAST CANCER CELLS:CELL CYCLE ANALYSIS AND BSA &DNA-BINDING STUDY ». Doctoral thesis, Università degli Studi di Milano, 2010. http://hdl.handle.net/2434/150047.

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N6-Isopentenyladenosine (iPA) is a member of the cytokinins, a family of plant hormones that regulate plant cell growth and differentiation. iPA is present in mammalian cells in a free form, as a mononucleotide in the cytoplasm, or in a tRNA-bound form. Kinetin Riboside (KR) is devoid of cyclin-dependent kinase inhibitory activity and displayed potent antiproliferative activity against various human cancer cell lines and induced apoptosis in human myeloid leukemia cells. Earlier research has demonstrated that KR antiproliferative and apoptogenic activities are antagonized by pharmacological inhibitors of adenosine kinase (ADK), suggesting that KR bioactivation through metabolic conversion into the nucleotide form is essential for KR cytotoxicity. Apoptotic mechanism of iPA and KR led us to study in details the dose-dependent cell cycle arrest and apoptogenic effect of iPA and KR on MCF-7 breast and HCT-15 colon cell lines. On the other hand, cell cycle progression or apoptosis can be affected by activation of cell cycle checkpoints in response to DNA damage. We have also studied the interaction of iPA with DNA& BSA as a complementary information related to iPA antiproliferative activity.

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Denmon, Andria. « The Role of Base Modifications on Tyrosyl-tRNA Structure, Stability, and Function in Bacillus subtilis and Bacillus anthracis ». Thesis, 2013. http://hdl.handle.net/1911/71946.

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tRNA molecules contain more than 80 chemically unique nucleotide base modifications that contribute to the chemical and physical diversity of RNAs as well as add to the overall fitness of the cell. For instance, base modifications have been shown to play a critical role in tRNA molecules by improving the fidelity and efficiency of translation. Most of this work has been carried out extensively in Gram-negative bacteria, however, the role of modified bases in tRNAs as they relate to thermostability, structure, and transcriptional regulation in Gram-positive bacteria, such as Bacillus subtilis and Bacillus anthracis, are not well characterized. Infections by Gram-positive bacteria that have become more resistant to established drug regiments are on the rise, making Gram-positive bacteria a serious threat to public safety. My thesis work examined what role partial base modification of the tyrosyl-anticodon stem-loops (ASLTyr ) of B. subtilis and B. anthracis have on thermostability, structure, and transcriptional regulation. The ASLTyr molecules have three modified residues which include Queuine (Q34), 2-thiomethyl-N6-dimethylallyl (ms2i6A37), and pseudouridine (Y39). Differential Scanning Calorimetry (DSC) and UV melting were employed to examine the thermodynamic effects of partial modification on ASLTyr stability. The DSC and UV data indicated that the Y39 and i6A37 modifications improved the molecular stability of the ASL. To examine the effects of partial base modification on ASLTyr structure, NMR spectroscopy was employed. The NMR data indicated that the unmodified and [Y39]-ASLTyr form a protonated C-A+ Watson-Crick-like base pair instead of the canonical bifurcated C-A+ interaction. Additionally, the loop regions of the unmodified and [Y39]-ASLTyr molecules were well ordered. Interestingly, the [i6A37]- and [i6A37; Y39]- ASLTyr molecules did not form a protonated C-A+ base pair and the bases of the loop region were not well ordered. The NMR data also suggested that the unmodified and partially modified molecules do not adopt the canonical U-turn structure. The structures of the unmodified, [Y39]-, and [i6A37;Y39]-ASLTyr molecules did not depend on the presence of Mg2+, but the structure of the [i6A37]-ASLTyr molecule did depend on the presence of multivalent cations. Finally, to determine the repercussions that partial modification has on physiology and tRNA mediated transcriptional regulation in B. anthracis, antibiotic sensitivity tests, growth curves, and quantitative real-time polymerase chain reaction (qRT-PCR) were employed. Strains deficient in ms2 showed comparable growth to the parent strain when cultured in defined media, but Q deficient strains did not. The loss of ms2i6A37 conferred resistance to spectinomycin and ciprofloxacin, whereas the loss of Q34 resulted in sensitivity to erythromycin. Changes in the ratio full-length to truncated transcripts of the tyrS1 and tyrS2 genes were used to monitor tRNA mediated transcriptional regulation. The qRT-PCR data suggested that tyrS1 and tyrS2 are T-box regulated and that the loss of ms2i6A37 and Q34 might affect the interaction of the tRNATyr molecule with the specifier sequence, which is located in the 5’-untranscribed region (UTR) of the messenger RNA (mRNA).

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