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1
Larsen, K. « Tanaidacea (Peracarida) from Macaronesia I. The deep-water fauna off the Selvagen Islands, Portugal ». Crustaceana 85, no 4-5 (2012) : 571–89. http://dx.doi.org/10.1163/156854012x633376.
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Three new species of Tanaidacea are described from the Portuguese Selvagen Islands in the Mid-Atlantic, and collected during the EMPC expedition on board the “N.R.P. Almirante Gago Coutinho” in the summer of 2010. The new species belong to the tanaidomorphan genera, Bathyleptochelia, Pseudoarthrura, and Typhlotanais.
2
Takiguchi, Katsuki. « Structure of Rumor Disaster – On Fukushima Daiichi N.P.P. Unit 4 – ». Journal of Disaster Research 16, no 6 (15 septembre 2021) : 933–35. http://dx.doi.org/10.20965/jdr.2021.p0933.
Texte intégralRésumé :
The misleading information spreads into the society, the people move on the basis of it. This mechanism, what I call “rumor disaster” is examined in this note. Authorities, specialists, intellectuals, and so on, oftentimes, might take part in this process. In this note, the spent fuel storage pool of Tokyo Electric Power Fukushima Daiichi N.P.P. Unit 4 is the case used for discussion because there are relatively abundant materials and the resulting impact to the society is very big.
3
Fonseca, Diego Barros. « Práticas funerárias no baixo rio tapajós, Amazônia ». Amazônica - Revista de Antropologia 10, no 1 (19 août 2018) : 298. http://dx.doi.org/10.18542/amazonica.v10i1.5864.
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O artigo trata de uma série de urnas e vasilhas relacionadas a práticas de sepultamento provavelmente de indígenas Mundurucu, no baixo rio Tapajós, vindos do sítio arqueológico Nossa Senhora do Perpétuo Socorro (N.S.P. Socorro) - Itaituba, Pará. Avalia-se então as semelhanças com dados etnohistóricos e arqueológicos sobre as práticas funerárias na região, a descrição das escavações em laboratório, apresentando dados e interpretações sobre os vestígios osteológicos encontrados, contribuindo com os debates sobre as práticas funerárias na região Amazônica.
4
ڕابەر فەرھاد حوسێن et عاطف عەبدوڵلا فەرهادی. « زمانەوانی دەماری و ڕۆڵی N.L.P لە بونیادنانی مامۆستایانی زمانی کوردی ». گۆڤاری ئەکادیمیای کوردی, no 52 (11 octobre 2022) : 47–88. http://dx.doi.org/10.56422/ka..52.86.
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ئەم لێکۆڵینەوەیە بەناونيشانى (زمانەوانى دەمارى و ڕۆڵی پڕۆگرامی زمانەوانی دەماری لە بونيادنانى مامۆستايانى زمانى كوردی ـ قوتابخانەكانى هەولێر بەنموونە)يە, هەڵگرى پەيامێکە دەخوازێت برەو بە تواناكانى مامۆستايان بدات، چونکە مامۆستایان پێشەواى ميللەتن, لەم ڕێگەیەوە كەرتى پەروەردە و فێركردن گەشە بكات و نەوەيەكى زانستخواز و خاوەن ديد و پەيام و ئامانج دروستبكات, هەموو ئەوانەش لە خزمەت بووژانەوەی كۆمەڵگاى كوردیدایە. ئەم لێکۆڵینەوەیە لە دوو بەش پێکهاتووە لە بەشی یەکەم باسی زمانەوانی دەماری و هەندێک زانیاری لەبارەی مێشکی مرۆڤ و شەپۆڵەکانی مێشک و هەردوو نیوە گۆی مێشک و ئەقڵی ئاگا و ئەقڵی نا ئاگا دەکەین. بەڵام لە بەشی دووەم باسی: ڕۆڵی (پڕۆگرامی زمانەوانی دەماری) دەکەین لە بەرزکردنەوەی تواناکانی مامۆستایانی زمانی کوردی, ھەروەھا ئەو جیاوازییە دەخەینە ڕوو کە لە نێوان (2) مامۆستا بەدی دەکرێت کە یەکیان خولی (پڕۆگرامی زمانەوانی دەماری) دیتووە ئەوەی تریان شارەزایی لەو بوارە نییە. ھەروەھا باسی پلانی ستراتیژی تاکە کەس دەکەین بۆ مەبەستی گەشەدان بە تواناکانی مامۆستایان. باسی شێوازەکانی زانیاری وەرگرتن دەکەین, باسی بەھێزبوونی یادگە و تەرکیز دەکەین. ھەروەھا باسی پڕۆسەی ئاڵوگۆڕکردنی زانیاری دەکەین لە نێوان مامۆستا و قوتابییان. باسەکە دەکەوێتە چوارچێوەی (زمانەوانی دەماری و دەروونی), کە لقێکە لە لقەکانی زمانەوانی کارەکی.
5
Loew, Clemens A. « The Evolution of N.I.P. in a Historical Perspective : A Founder's Reflections ». Psychoanalytic Perspectives 1, no 1 (mars 2003) : 7–10. http://dx.doi.org/10.1080/1551806x.2003.10472879.
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Debos, Franck. « N.I.P. (Nouveaux instruments promotionnels) et promotions des marques : vers une synergie nécessaire ». Market Management 6, no 1 (2006) : 6. http://dx.doi.org/10.3917/mama.031.0006.
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Sanchis, R., I. Tkachenko, G. Verdú, J. L. Muñoz-Cobo, M. D. Bovea et D. Ginestar. « New approach to the decay ratio estimation in B.W.R. N.P.P. : Frequency-moments technique ». Annals of Nuclear Energy 24, no 2 (janvier 1997) : 113–33. http://dx.doi.org/10.1016/0306-4549(96)00073-4.
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Levine, Ronnie. « Afterthoughts : Comments and Reactions to the N.I.P. 15™ Annual Conference : Shame and Sexuality ». Psychoanalytic Perspectives 2, no 1 (octobre 2004) : 101–5. http://dx.doi.org/10.1080/1551806x.2004.10472902.
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Andreev, A. J., Leonid L. Borodkin et Juri L. Kir-Janov. « Les conflits du travail en Russie soviétique pendant le « communisme de guerre » et la N.E.P. » Le Mouvement Social 196, no 3 (2001) : 41. http://dx.doi.org/10.3917/lms.196.0041.
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Andreev, A. J., Leonid I. Borodkin, Juri I. Kir'janov et Jean-Paul Depretto. « Les conflits du travail en Russie sovietique pendant le "Communisme de guerre" et la N.E.P. » Le Mouvement social, no 196 (juillet 2001) : 41. http://dx.doi.org/10.2307/3779634.
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Jamie, Faiz Omar Mohammad. « The Emergence and Development of National Congress Party in Sudan (1998-2005) ». International Journal of Social Science Studies 5, no 2 (14 janvier 2017) : 23. http://dx.doi.org/10.11114/ijsss.v5i2.2147.
Texte intégralRésumé :
The paper analyses the emergence of the National Congress Party (N.C.P.) within the context of the recent political history of Sudan in post 1989 era. The date marks the time when Islamists in Sudan assumed power following a coup d’état led by General Omer Al-Bashir, latter on came to be known as the Ingaz regime. The significance of the experience of this Party emanates from the fact that, though it started as a one ruling party, it managed to conclude in 2005 the Comprehensive Peace Agreement (C.P.A.) a major peace agreement ending one of the longest internal wars in Africa. The Agreement was included in the Constitution of the country, consequently hosting Sudan People’s Liberation Movement (SPLM), the movement which led the rebellion to become a partner party/movement in the rule of the country. The paper reflects on this power sharing experience during the Interim Period up to 2011 wherein the Referendum on Self-determination of South Sudan resulted in dividing the Country into two sovereign states.
12
Slate, John R., et Craig H. Jones. « Helping Behaviorally At-Risk Middle School Students With the No Bad Actions Program : Winning With the N.B.A. » Journal of Education for Students Placed at Risk (JESPAR) 8, no 3 (juillet 2003) : 351–62. http://dx.doi.org/10.1207/s15327671espr0803_4.
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Pavel Nita, Iulian, A. R. Olteanu, Camelia Coman et Hortensia Beznila. « ADVANTAGES AND CONSTRAINTS OF SPECIFIC AUTOCAD PLANT 3D FUNCTIONS FOR DYNAMIC MANAGEMENT - CASE STUDY FOR A HEAVY WATER DETRITIATION INSTALLATION AT CERNAVODA N.P.P. » SMART ENERGY AND SUSTAINABLE ENVIRONMENT 25, no 1 (4 avril 2022) : 5–14. http://dx.doi.org/10.46390/j.smensuen.25122.443.
Texte intégralRésumé :
The advantages and constraints of the specific Autocad Plant 3D functions for dynamic management - production of technological diagrams, isometrics, orthogonal views, bills of materials and piping system erection projects for the future detritiation facility at the Cernavodă Nuclear Power Plant (Cernavoda N.P.P.) are presented in a case study. In last decades 3D modelling of the plant has been increasing used in design of new projects in nuclear power plant (NPP) both in design period but also in design changes required during life time and extended life time of a plant. In the proposed case we developed a model to make an engineering design application for plant design incorporating disciplines such as piping, piping support, equipment, civil and steel structure. Using 3D Plant capabilities we can improve design process, interdisciplinary check-out as well as project execution. The project could be updated after as built revision of isometric drawings in order to obtain a training model for the system to prepare plant operators to make scheduled and unscheduled maintenance and time estimation of different maintenance procedures that could be required during plant operation in order to reduce as low as reasonable possible dose received during detritiation installation maintenance.
14
Baleux, B., J. Alibou, M. Troussellier et P. Got. « Utilisation du bouillon sélénite F modifié pour dénombrer Salmonella dans les milieux aquatiques ». Revue des sciences de l'eau 1, no 4 (12 avril 2005) : 401–8. http://dx.doi.org/10.7202/705019ar.
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Ce travail a pour objet de présenter une nouvelle méthode de dénombrement des Salmonella dans différents types d'eaux (de rivière, saumâtre, eaux usées brutes et épurées) basée sur l'utilisation d'un milieu d'enrichissement au sélénite additionné de Novobiocine et de Pril et sur une adaptation de la technique du N.P.P. à l'ensemencement d'échantillons de grands volumes après filtration permettant de quantifier les très faibles concentrations de Salmonella. Les vérifications des performances de cette méthode d'isolement et de quantification sont basées sur l'étude des croissances de différentes souches de Salmonella et d'autres espèces bactériennes dans le milieu d'enrichissement modifié, ainsi que sur les résultats quantitatifs et qualitatifs fournis par cette méthode lorsqu'elle est appliquée à des échantillons d'eau en provenance de l'environnement aquatique. Ces résultats montrent notamment que la méthode proposée est suffisamment sensible pour détecter 1 à 2 Salmonella dans 10 litres d'eau analysée et qu'elle ne parait pas exclure de sérotypes, du moins parmi ceux les plus fréquemment isolés en France. L'efficacité de la méthode standardisée API Z pour l'identification enzymatique du genre Salmonella a été également testée en référence aux résultats de la sérotypie.
15
Dagg, I. R., A. Anderson, T. F. Gmach, C. G. Joslin et W. Smith. « The octopole and hexadecapole moments of N2O from collision-induced absorption measurements ». Canadian Journal of Physics 68, no 12 (1 décembre 1990) : 1440–45. http://dx.doi.org/10.1139/p90-206.
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The absorption spectrum of gaseous N2O was measured in the spectral region from approximately 15–120 cm−1 at 11 different densities from 3.3 to 64.5 amagat. (An amagat is defined as the density of a gas at N.T.P.) The data were obtained with a Michelson Fourier transform IR spectrometer and a far IR laser using a stainless steel absorption cell 9.26 cm in length. From the density dependence of the absorption, the collision-induced spectrum above approximately 60 cm−1 was clearly separated from the relatively strong allowed transitions peaking at the lower frequency near 22 cm−1. From theoretical expressions for the line shape, derived using information theory, and a reliable value of the quadrupole moment (obtained from the birefringent measurements), we estimate the octopole moment to be 7.6 × 10−34 esu and the hexadecapole moment to be 16.9 × 10−42 esu. Alternatively, if the hexadecapolar contribution is considered to be negligible, then we estimate the octopole moment to be 9 × 10−34 esu. These results are consistent with measurements of the total integrated absorption of the IR band assuming a theoretical expression for the contribution due to the allowed dipole transitions.
16
Sharma, Runumi, et Mamta Aswal. « Contemporary Relevance of Bertrand Russell’s Views on Early Childhood Education ». Issues and Ideas in Education 9, no 1 (31 mars 2021) : 33–37. http://dx.doi.org/10.15415/iie.2021.91004.
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Bertrand Russell’s educational thoughts significantly deal with reforming education for school going children and he also supported pre-primary education. He favored early childhood education for physical, intellectual and character development. His emphasis on character development of a child shows the significance of early years of life for development of an individual. This paper aims at exploring Bertrand Russell’s thoughts on early childhood education. It is an attempt to understand the significance of early childhood education for the holistic development of the children. Though there are early childhood education is prevalent in our country, but it was not mandatory to get early childhood education till the approval of National Education Policy (N.E.P., 2020). It has included early childhood education in compulsory school education for promoting better learning and well being of a child. It is a qualitative research in which historical method has been used where data has been collected from primary and secondary sources. The finding of the study shows that Bertrand Russell’sthought on early childhood education is relevant in present Indian context for developing good values, physical and mental development as well as in future learning. This shows that the encouragement to early childhood education and Bertrand Russell’s thoughts on early childhood education would be helpful for holistic development of children.
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Sivanmaliappan, Tamil Selvi, et Murugan Sevanan. « Antimicrobial Susceptibility Patterns ofPseudomonas aeruginosafrom Diabetes Patients with Foot Ulcers ». International Journal of Microbiology 2011 (2011) : 1–4. http://dx.doi.org/10.1155/2011/605195.
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Pseudomonas aeruginosais an invasive organism that frequently causes severe tissue damage in diabetic foot ulcers. A major problem inP. aeruginosainfection may be that this pathogen exhibits a high degree of resistance to a broad spectrum of antibiotics. The study aimed to isolate and determine the antimicrobial susceptibility patterns of theP. aeruginosapopulation from diabetes patients with foot ulcers attending tertiary care hospitals in and around Coimbatore and their antimicrobial susceptibility pattern. The study was carried out at the Department of Microbiology, Dr. N.G.P. Arts and Science College, Coimbatore, for a period of one year (June 2006 to April 2007). The present study comprised 270 pus specimens collected from diabetic patients with foot ulcers. All pus samples were subjected to gram staining; bacterial culture and subsequently the antibiotic sensitivity to 15 different antibiotics for the confirmedP. aeruginosawere performed as per the standard procedures. Eighteen strains (14.28%) ofP. aeruginosafrom 270 diabetic foot ulcers were detected. Almost all the strains exhibited a varying degree of resistance to the antibiotics tested. Multidrug resistance for about 8 to 11 antibiotics was observed among the 55.5% of the isolates. Disk diffusion results show 100% resistance to ampicillin, cefoperazone, erythromycin, norfloxacin, and only cefotaxime, ciprofloxacin exhibited greater activity againstPseudomonas aeruginosa.
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Seijmonsbergen, A. C., D. T. Biewinga et A. P. Pruissers. « A geophysical profile at the foot of the Dutch coastal dunes near the former outlet of the ‘Old Rhine’ ». Netherlands Journal of Geosciences - Geologie en Mijnbouw 83, no 4 (décembre 2004) : 287–91. http://dx.doi.org/10.1017/s0016774600020370.
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AbstractThe apparent electrical conductivity of the subsurface along the Dutch coast between ‘Wassenaarse Slag’ (beach post 92.250) and north of Noordwijk aan Zee (beach post 77.750) reflects the spatial distribution of Holocene coastal deposits. Using a Geonics EM-34 a threefold division based on the mean electrical conductivity could be made in the outlet area of the River Old Rhine. 1) A section showing a sequence of sandy deposits that resembles the Schoorl Member of the Naaldwijk Formation on top of the Zandvoort Member of the Naaldwijk Formation. 2) A section underlain by a shallow clay/peat layer of varying thickness belonging to the Naaldwijk Formation (Walcheren Member) / Nieuwkoop Formation (Hollandveen Member), intercalated within the Schoorl Member and Zandvoort Member of the Naaldwijk Formation. South of the Old Rhine locally Wormer Member deposits of the Naaldwijk Formation underlie these clay/peat layers. 3) A section characterized by channel fill deposits of the former Rhine reaching to -20 m below Normaal Amsterdam Peil (N.A.P.), and belonging to deposits of the Wormer Member of the Naaldwijk Formation, and to two facies of the Naaldwijk Formation (Walcheren Member). The geophysical transect was calibrated using existing nearby drill hole data, so that a continuous snapshot of the subsurface was gained. Therefore this research also contributes to the recent genesis of this part of the Dutch coast.
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Gandhi, Piyush Prashant, et Riyaz Ahmed Siddiqui. « Effects of peppermint, chewing gum on memory, cognition, alertness, reaction time, arithmetic skills and athletic performance during laboratory induced stress in undergraduate medical students ». International Journal of Basic & ; Clinical Pharmacology 8, no 6 (23 mai 2019) : 1254. http://dx.doi.org/10.18203/2319-2003.ijbcp20192185.
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Background: Many medical students are dealing with day to day stress in their lives and they need to be both physically and mentally active to counter and overcome their daily problems. In such scenario, a non-pharmacological adjunct could prove useful to counter all of it so that they can work more efficiently. Many universities do recommend the use of peppermints and chewing gums. This study is conducted to see if any of these items actually have an influence on cognitive and physical abilities.Methods: A non-randomized controlled trial was performed on the undergraduate medical students of N.K.P. Salve Institute of Medical Sciences and Research Centre belonging to the age group of 18-21 years. They were given normal flavoured gum, mint flavoured gum and peppermint. A series of cognitive and physiological tests in both stressful and stress free environments were performed.Results: Consumption of peppermint in a stressful environment showed increase in attention span of the subjects and it increased the intelligence Wechsler Adult Intelligence Scale-R (WAIS-R) in both stress free and stressful environments. As compared to normal gum, peppermint and peppermint gum proved to be more effective. There was no significant change observed in alertness, reaction time, arithmetic ability, short term memory and fatigue index in any of the subjects.Conclusions: Peppermint has caused increase in the attention span and intelligence of medical students in a stressful work scenario. Peppermint gum was found to be more beneficial than normal gum.
20
Dagg, I. R., A. Anderson, W. Smith, P. J. Reid, C. G. Joslin et C. G. Gray. « Collision-induced absorption in cyclopropane (C3H6) ». Canadian Journal of Physics 70, no 2-3 (1 février 1992) : 134–39. http://dx.doi.org/10.1139/p92-017.
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We have measured the far-infrared absorption spectrum of cylopropane (C3H6) at frequencies up to 400 cm−1, at densities up to 5 amagat at 295 K and up to 16 amagat at 360 K, using a combination of Fourier-transform and laser techniques. (An amagat is defined as the density of a gas at N.T.P.). By studying the density-dependence of absorption, we have isolated the collisional component of the spectrum. This arises from pair dipole moments induced by the permanent quadrupole, octopole, and hexadecapole moments of the C3H6 molecule. To the extent that the intermolecular potential is isotropic, the induced spectrum can be expressed as the convolution of symmetric top free rotation spectra with translational spectra representing the relative motion of an interacting molecular pair. The former are calculated using expressions recently derived. For the latter we use information theory to provide a "least-biased" estimate based only on available information concerning the zeroth and second moments of the translational frequency spectrum, which can be calculated without approximation within the framework of equilibrium statistical mechanics. The result of these computations is a simple analytic expression for the absorption coefficient [Formula: see text], which is entirely free of adjustable parameters, and yet yields a good representation of the experimental results over most of the frequency range. Our results lend strong support to the theoretical values of the multipole moments calculated by other workers.
21
Hugues, B., et Ch Pietri. « Influence du volume d'inoculum dans la quantification des virus selon deux techniques comparees : Plages et N.P.P. utilisant un grand nombre d'inoculum par dilution ». Chemosphere 14, no 1 (janvier 1985) : 149–53. http://dx.doi.org/10.1016/0045-6535(85)90050-5.
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Anaya García, Claudina Esther, Maryluz Gómez Plata et Carmelina Paba Barbosa. « Eficacia de un programa para el desarrollo del pensamiento formal en estudiantes de 9° de un colegio público del departamento del Magdalena ». Psicogente 22, no 42 (3 juillet 2019) : 1–23. http://dx.doi.org/10.17081/psico.22.42.3492.
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Objetivo: Evaluar la eficacia del programa psicoeducativo para la estimulación y desarrollo del pensamiento formal N.A.P diseñado por Núñez, Anaya y Prieto (2014) en estudiantes de 9° de un colegio público del departamento del Magdalena.
Método: Es un estudio de tipo cuantitativo, con un diseño cuasiexperimental antes y después, con un grupo control no equivalente; la muestra estuvo conformada por 48 estudiantes de 13 a 17 años, 25 de sexo masculino y 23 de sexo femenino, seleccionados a través de un muestreo no probabilístico intencional. 27 estudiantes hicieron parte del grupo experimental y fueron sometidos al programa durante 5 meses con una intensidad de una hora semanal; mientras los 21 alumnos del grupo control no fueron intervenidos. La eficacia del programa se determinó por medio de la prueba TOLT (Tobín & Capie, 1981).
Resultados: Mediante el estadístico T de Student se halló un valor 0,003 menor del margen de error, indicando variaciones significativas entre el pre-test y pos-test del grupo experimental, y en el grupo control no hubo ninguna significancia, lo que indica que el programa tuvo éxito en la estimulación del pensamiento formal.
Conclusión: Los hallazgos de la investigación demostraron la eficacia del programa para el desarrollo del pensamiento formal, en el pos-test del grupo experimental el 38 % de estudiantes se ubicaron en transición y el 3 % en el nivel formal; en el grupo control el 100 % de estudiantes antes y después se ubicaron en el nivel concreto. Además, las habilidades potenciadas con las actividades del programa fueron la proporcionalidad y correlación, por tanto puede ser de utilidad en la academia para estimular este tipo de pensamiento.
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Bastos, Leticia Vilaça Willeman, Ricardo de Souza Tesch et Odilon Victor Denardin. « Alterações cefalométricas presentes em crianças e adolescentes com desordens da ATM nas diferentes classificações sagitais de má oclusão ». Revista Dental Press de Ortodontia e Ortopedia Facial 13, no 2 (avril 2008) : 40–48. http://dx.doi.org/10.1590/s1415-54192008000200006.
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INTRODUÇÃO: o acometimento da ATM por alterações degenerativas e deslocamentos do disco articular demonstrou ser um fator de risco para a identificação de indivíduos com padrões hiperdivergentes de crescimento facial. OBJETIVOS: avaliar diferenças entre as médias encontradas para as variáveis cefalométricas em crianças com DTM articular e grupo controle, nas diferentes classificações sagitais de má oclusão (Classe I, II e III de Angle). MÉTODO: foram incluídos crianças e adolescentes com idade máxima de 17 anos, divididos em grupo experimental (n = 30) com diagnóstico de DTM articular, segundo o eixo I do RDC/TMD para crianças e adolescentes, igualmente divididos em 3 sub-grupos (n= 10) de acordo com a classificação da má oclusão presente e grupo controle (n = 30) sem DTM, pareados por gênero, índice de maturidade esquelética vertebral cervical e classificação da má oclusão. Foram traçadas telerradiografias laterais e as estruturas craniofaciais e suas relações foram divididas em: base do crânio, maxila, mandíbula, relações intermaxilares, relações esqueléticas verticais e relações dentárias. As diferenças encontradas entre as médias, para cada uma das variáveis, foram avaliadas pela aplicação do teste estatístico t de Student para amostra independentes. RESULTADOS: o grupo experimental Classe I apresentou S.N.Ar (p = 0,05) aumentado, o grupo experimental Classe II apresentou S.N.Ar (p = 0,006) e NperpA (p = 0,037) diminuídos e S.Ar.Go (p = 0,045) aumentado e o grupo experimental Classe III apresentou N.A.P (p = 0,045), 1.NB (p = 0,001) e 1-NB (p = 0,017) aumentados e 1.1 (p = 0,004) diminuído, todos em relação aos seus respectivos controles CONCLUSÃO: as diferenças foram mais significantes nos pacientes com má oclusão de Classe II e de Classe III.
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Rubio-Martinez, Araceli, Valle Recasens, Maria D. Odero, Daniel Rubio-Felix, Maria J. Calasanz, Pilar Mayayo, Manuel Giralt et Pilar Giraldo. « CML and Imatinib Mesylate : Response Related to Karyotype. » Blood 106, no 11 (16 novembre 2005) : 4866. http://dx.doi.org/10.1182/blood.v106.11.4866.4866.
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Abstract Background: Imatinib mesylate (STI571), as a specific inhibitor for tyrosine kinase product of oncoprotein Bcr/Abl. Efficacy of Imatinib is questioned when other cytogenetics abnormalities associated to t(9;22) are present. We describe our experience in CML patients treated with Imatinib in one centre, evaluating hematological (HR) and cytogenetic response (CR) related to kariotype. Patients and methods: 28 patients diagnosed as having CML, 1990–2005, Imatinib 400–800 mg/d, were stratified according to cytogenetic abnormalities: Group A: t(9;22) typical in 19 patients, Group B: patients with t(9;22) and different genomic rearrangement associated: 9. At diagnosis were classified in stages Kantarjian score and the cytogenetic study (kariotype, % metaphases Ph, FISH and PCR/RT-PCR in bone marrow (BM) and peripheral blood (PB)). HR was evaluated monthly and CR in BM every 3–6 months. In patient with complete cytogenetic response (CCR) we performed follow-up in PB by RT-PCR every 3 months and a cytogenetic study in BM once a year. Cytogenetic response (CR) was quantified by n° metaphases Ph in BM: 0% CCR, 1–35% partial (PCR), 36–95% minor (MCR) and > 95% failure (F). Molecular response (MR): normal kariotype (Bcr/Abl negative and RT-PCR<5 copies). Statistical analysis: Chi-cuadrado and Kaplan-Meier survival test. Results: 18 M /10 F (2 died by blast crisis), mean age 50 (range 30–72), Kantarjian score: A group (4: 2pts, 3: 5pts, 2: 5pts, 1: 7 pts). Mean time on therapy: 26.46 m (1–51 ). Previous therapy: α-interferon 7, α-interferon/pegilated 1, α-interferon/α-interferon+citarabine 3, α-interferon+citarabine 6. Imatinib as first line: 11. When Imatinib started: accelerated phase 3, chronic phase 23 and chronic phase post-blast crisis2. The results of therapy are in table I. We have not observed statistically significant differences (s.s.d) in MR (p=.577) and in OS (p=.581) between group A and B with the same doses. Two patients that had started therapy with Imatinib 800 mg/day (group A) reached MR three months later. In group B one patient 12 months after got MR surprisingly developed a ALL Ph’, he received chemotherapy plus Imatinib 800 mg/day and 6 months later he is in CCR. Conclusions: Three months after Imatinib therapy HR was 100% in both groups. One year undergoing therapy CR response was higher in A group (81% vs 50%). Nevertheless the n° of MR obtained in patients with complex karyotypes receiving Imatinib 400 mg/day has been high (33.3%) and without s.s.d.with those with classical translocation. Hematological and Cytogenetic response to Imatinib Months N.E.P. A Group (19) N.E.P. B Group (9) 1 19 HR : 100% 9 HR :78% 3 10 HR:100%. CR 7 (70%): 4CCR(2MR), 2PRC, 1MRC, 3F. 3 HR: 100%. CR 2 (67%): 2MCR, 1F 6 16 HR: 94%. CR: 12 (75%), 7CCR (3MR), 3PRC, 2MCR, 4F 6 HR: 86%. CR 4 (67%): 3CCR, 1MCR, 2F 12 16 HR: 94%. CR 13 (81%): 11CCR (6MR), 2PRC, 3 F 4 HR: 100%. CR 2 (50%): 2CCR (1MR), 2F 18 13 HR: 100%. CR 12 (92%): 10CCR (6MR), 2PRC, 1F 5 HR: 80%. CR 3(60%): 3CCR (2 MR), 2F 24 13 HR: 93%. CR 12 (92%): 10CCR (7MR), 2PRC, 1F 6 HR: 83%. CR : 4 (67%): 3CCR (3 MR*), 1PRC, 2F 36 4 HR: 100%. CR 3 (75%): 2CCR (1MR), 1PRC, 1F 5 HR: 60%. CR 2 (40%): 2CCR (2MR), 3F 48 2 HR: 100%. CR 1 (50%): 1 PRC,1F 0 MR:N 10 (52,6%). Mean time : 12 m (3–24 m). Imatinib : 488,88 mg/d, Months in MR : mean 15.8 (9–21m) 3 (33.3%). Mean time : 18 months (12–26 m). Imatinib : 400 mg/day. Months in MR : mean 18 (12–26 m)
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Graham, Matthew R. « Scorpions of the WorldScorpions of the World. Roland Stockmann , Eric Ythier . 2010. N.A.P. Editions. France. 567 pp. ISBN : 978-2-913688-11-7. 75€. » Journal of Arachnology 39, no 1 (avril 2011) : 166–67. http://dx.doi.org/10.1636/0161-8202-39.1.166.
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Mahmud, Noorfadhleen Binti, Nadrawina Isnin, Noni Harianti binti Junaidi et Nursuria binti Mahrif. « Understanding the Complexities of Sarawak Women’s Social Participation in Non-Governmental Organizations ». GATR Global Journal of Business Social Sciences Review 10, no 3 (25 septembre 2022) : 114–20. http://dx.doi.org/10.35609/gjbssr.2022.10.3(1).
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Objective - The purpose of this study is to gain an understanding of the issues that prevent women from socially participating in NGOs. Methodology/Technique – Qualitative research using in-depth interviews was used to collect relevant data. The findings were analyzed using a thematic analysis approach and discussed within the theoretical framework of social participation. In response to the nature of women’s social participation in Sarawak, the researchers highlighted long, critical answers and discussions by 36 selected participants from various NGOs in Sarawak. Finding –There were four difficulties for Sarawak women’s social participation in NGOs identified in this study. The factors were practical deterrents, a psychological barrier, discrimination and prejudice, and lack of resources. The impeding factors which were grouped in these four categories comprised 16 factors. This study hoped to help the stakeholders develop different strategies for assisting women to be more aware and active in a civil-based society. Novelty –The study highlighted the complex factors of Sarawak women’s social participation in NGOs. These factors show different perspectives on the subject investigation in Sarawak, Malaysia. Furthermore, the adapted qualitative method conducted in this paper is further discussed regarding the complex factors of Sarawak women’s social participation in NGOs. There are many studies conducted exploring political participation. However, studies on social participation that focused on NGOs that are not politically based are very low. Type of Paper: Empirical JEL Classification: D71, D73, Z19. Keywords: Non-governmental organizations; Social Participation; complexities; Sarawak’s Women. Reference to this paper should be referred to as follows: Mahmud, N.B.M; Isnin, N.I; Junaidi, N.H.B; Mahrif, N.B. (2022). Understanding the Complexities of Sarawak Women’s Social Participation in Non-Governmental Organizations, GATR-Global J. Bus. Soc. Sci. Review, 10(3), 114–120. https://doi.org/10.35609/gjbssr.2022.10.3(1)
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Niedźwiedź, Malwina Julita, Małgorzata Gil, Mateusz Gargol, Wiesław Marian Podkościelny et Paweł Mergo. « Determination of the optimal extrusion temperature of the PMMA optical fibers ». Photonics Letters of Poland 11, no 1 (3 avril 2019) : 7. http://dx.doi.org/10.4302/plp.v11i1.889.
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The aim of this work was to determine optimal extrusion temperature for polymer optical fibers. For preliminary studies poly(methyl methacrylate) (PMMA) granulate was used. Samples of commercially available PMMA were subjected to four different temperatures in which were kept in oven for three different period of time. To examine the changes in the chemical structure of the polymer, an ATR-FT-IR (Attenuation Total Reflection Fourier Transform Infrared Spectroscopy) was chosen. Full Text: PDF ReferencesK. Peters, "Polymer optical fiber sensors—a review", Smart Mater. Struct. 20, 013002 (2011) CrossRef O. Ziemann, J. Krauser, P.E. Zamzow, W. Daum, "POF Polymer Optical Fibers for Data Communication" (New York, Springer-Verlag Berlin Heidelberg 2002). CrossRef M.A. van Eijkelenborg, M.C.J. Large, A. Argyros, J. Zagari, S. Manos, N.A. Issa, I. Bassett, S. Fleming, R.C. McPhedran, C. Martijn de Sterke, N.A.P. Nicorovici, "Microstructured polymer optical fibre", Opt Express 9, 319 (2001). CrossRef O. Çetinkaya, G. Wojcik, P. Mergo, "Decreasing diameter fluctuation of polymer optical fiber with optimized drawing conditions", Mater Res Express 5, 1 (2018). CrossRef P. Mergo, M. Gil, K. Skorupski, J. Klimek, G. Wójcik, J. Pędzisz, J. Kopec, K. Poruraj, L. Czyzewska, A. Walewski, A. Gorgol, "Low loss poly(methyl methacrylate) useful in polymer optical fibres technology", Phot. Lett. Poland, 5, 170 (2013). CrossRef J. Grdadolnik, "ATR-FTIR Spectroscopy: Its advantages and limitations", Acta Chim Slov. 49, 631 (2002). DirectLink P. Borowski, S. Pasieczna-Patkowska, M. Barczak, K. Pilorz, "Theoretical Determination of the Infrared Spectra of Amorphous Polymers", J Phys Chem A 116, 7424 (2012). CrossRef G. Socrates, "Infrared and Raman Characteristic Group Frequencies Tables and Charts" Third Edition (Baffins Lane Chichester, John Wiley & Sons Ltd 2001). DirectLink W. Schnabel, Polymer Degradation Principles and Practical Applications (Berlin, Akademie-Verlag 1981). DirectLink
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Paap, B. F., C. W. Dubelaar, J. L. Gunnink et A. P. Oost. « Unraveling the shallow geology of the western Wadden Sea using high resolution seismics ». Netherlands Journal of Geosciences - Geologie en Mijnbouw 91, no 3 (novembre 2012) : 341–55. http://dx.doi.org/10.1017/s0016774600000482.
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AbstractModelling of the shallow subsurface of the Dutch Wadden Sea is merely based on lithological information extracted from a limited amount of core samples. In order to improve the subsurface model and to provide a better basis for engineering purposes, seismic data have recently been acquired, processed and interpreted. This study focuses on the interpretation of seismic data in a pilot area in the southwestern part of the Dutch Wadden Sea near the Afsluitdijk. In order to acquire a maximum detail of subsurface information in a time-efficient way, multiple types of seismic systems were deployed simultaneously in a ‘one-sweep-survey’, providing information over depth ranges up to 60 m subsurface depth. Data from three seismic systems are presented; a chirp system, a boomer and sparker source in combination with hydrophone streamers. Geological interpretation of the seismic data was made by identifying seismic facies units and subsequently correlating them to geological cross-sections, running parallel to the Afsluitdijk. Geological cross-sections were derived from the existing geological and hydrogeological model and from relatively densely spaced borehole information. Six key reflectors were identified on the seismic data along the Dutch Afsluitdijk that make up four seismic facies units. Results of seismic profiles show good recognition of internal structures in especially Holocene sediments. A clay plug and a shallowing of a channel at the eastern side of the pilot area were interpreted as channel infills resulting from the rather sudden dominance by newer tidal channels to the west, probably coinciding with the opening of the Marsdiep channel. The channel wall deposits observed were interpreted as a turning of the drainage channel after closure of the IJsselmeer. Strong reflections of deeper levels (>15 m below Dutch vertical datum, i.e. N.A.P.) were interpreted as clay/sand interfaces in the Middle-Pleistocene Urk Formation and were more continuous than previously thought. It is concluded that high resolution seismics add valuable information yielding improved understanding of the sedimentary structure of the shallow subsurface, which in turn can be useful for near future engineering works along the Afsluitdijk.
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Goudie, A. S. « Book reviews : Dewey, J.F., Gass, I.G., Curry, G.B., Harris, N.B.W. and Sengör, A.M.C., editors, 1991 : Allochthonous terranes. Cambridge : Cambridge University Press. x + 202 pp. £37.50 cloth. ISBN : 0 521 40461 4 ». Progress in Physical Geography : Earth and Environment 17, no 1 (mars 1993) : 107–8. http://dx.doi.org/10.1177/030913339301700113.
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Boa, Eric. « Zúbrik, M. ; Kunca, A. ; Csóka, G., 2013 : Insects and Diseases Damaging Trees and Shrubs of Europe. Ed. by Zúbrik, M. ; Kunca, A. ; Csóka, G. N.A.P Editions, www.napeditions.com. 535 pp. ISBN 978-2-913688-18/6 ». Forest Pathology 45, no 5 (octobre 2015) : 440–41. http://dx.doi.org/10.1111/efp.12228.
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Man, Nguyen Minh, Nguyen Thi Phuong Chi, Wasino Wasino et Endah Sri Hartatik. « Ports, Maritime Networks, and Its Effect on the Development of the Ancient Kingdom of Southeast Asia ». Paramita : Historical Studies Journal 32, no 2 (29 septembre 2022) : 202–11. http://dx.doi.org/10.15294/paramita.v32i2.37833.
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Southeast Asia played an important role in global trade networks from before to the 15th century AD. This article aims to analyze the changes in maritime networks in the classical period of Southeast Asia and their influence on the development of ports and political centers in this region. The research method used is the historical method by utilizing relevant secondary sources. The analysis results show that long before Christ, the Southeast Asian region had become an arena of maritime networks with India and was followed by China at the beginning of the century AD. The sea transportation network connecting India, China, and the Middle East has influenced the growth of ports in Southeast Asia, which has implications for economic development and political power in the classical kingdoms. The initial trading network that China built until the mid-6th century AD gave birth to the development of the Funan kingdom with the port of Oc-Eo. Meanwhile, the China-Malacca Strait direct network shut down Funan’s ports with the shipping technology revolution. It encouraged the development of owned ports in the archipelago in succession in different periods, namely Sriwijaya, Majapahit, and Malacca, influencing economic and political consequences. These countries. The implications of this finding are the basis for generalizing the development of Pacific Asia trade and the economic and cultural interactions between maritime nations and regions worldwide. Asia Tenggara memainkan peran penting dalam jaringan perdagangan global dari sebelum hingga abad ke-15 Masehi. Artikel ini bertujuan untuk menganalisis perubahan jaringan maritim pada periode klasik Asia Tenggara dan pengaruhnya terhadap perkembangan pelabuhan dan pusat politik di kawasan ini. Metode penelitian yang digunakan adalah metode sejarah dengan memanfaatkan sumber-sumber sekunder yang relevan. Hasil analisis menunjukkan bahwa jauh sebelum Masehi, kawasan Asia Tenggara telah menjadi arena jaringan maritim dengan India dan diikuti oleh Cina pada awal abad Masehi. Jaringan transportasi laut yang menghubungkan India, Cina, dan Timur Tengah telah mempengaruhi pertumbuhan pelabuhan di Asia Tenggara, yang berimplikasi pada perkembangan ekonomi dan kekuatan politik di kerajaan-kerajaan klasik. Jaringan perdagangan awal yang dibangun Tiongkok hingga pertengahan abad ke-6 M melahirkan perkembangan kerajaan Funan dengan pelabuhan Oc-Eo. Sementara itu, jaringan langsung Selat Malaka-China menutup pelabuhan Funan dengan revolusi teknologi perkapalan. Hal tersebut mendorong berkembangnya pelabuhan-pelabuhan milik di Nusantara secara berturut-turut pada periode yang berbeda, yaitu Sriwijaya, Majapahit, dan Malaka, sehingga mempengaruhi konsekuensi ekonomi dan politik. Negara-negara ini. Implikasi dari temuan ini adalah dasar untuk menggeneralisasi perkembangan perdagangan Asia Pasifik dan interaksi ekonomi dan budaya antara negara dan wilayah maritim di seluruh dunia.Cite this article: Man, N.M., Chi, N.T.P., Wasino, Hartatik, E.S. (2022). Ports, Maritime Networks, and Its Effect on the Development of the Ancient Kingdom of Southeast Asia. Paramita: Historical Studies Journal, 32(2), 202-211. http://dx.doi.org/10.15294/paramita.v32i2.37833
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González-Foruria, I., I. Rodríguez, F. Martínez, J. Rodríguez-Purata, P. Montoya, D. Rodríguez, J. Nicolau, B. Coroleu, P. N. Barri et N. P. Polyzos. « Clinically significant intra-day variability of serum progesterone levels during the final day of oocyte maturation : a prospective study with repeated measurements ». Human Reproduction 34, no 8 (23 juillet 2019) : 1551–58. http://dx.doi.org/10.1093/humrep/dez091.
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Abstract STUDY QUESTION Is there significant variability in progesterone levels during the final day of oocyte maturation in women undergoing ovarian stimulation? SUMMARY ANSWER Progesterone levels drop from the basal level up to 44% during the final day of oocyte maturation in women undergoing ovarian stimulation. WHAT IS KNOWN ALREADY It has been suggested that elevated progesterone levels on the final day of ovarian stimulation may be related to poorer outcomes in in vitro fertilization fresh cycles due to a negative impact on the endometrium. However, despite conflicting results regarding the actual effect of progesterone on pregnancy rates and the lack of a well-established cut off, currently many IVF patients have their embryo transfer deferred when progesterone values surpass a threshold of 1.5 ng/ml on the day of ovulation triggering. STUDY DESIGN, SIZE, DURATION This was a prospective cohort study conducted in 22 oocyte donors of a university-affiliated fertility centre between November 2017 and January 2018. We calculated the sample size to detect a difference of 15% between the first and last progesterone measurements with a 5% false-positive rate in a two-sided test with 80% statistical power and a 95% confidence interval (CI). PARTICIPANTS/MATERIALS, SETTING, METHODS Progesterone circulating levels were evaluated at four different times during the final day of oocyte maturation (08:00, 12:00, 16:00 and 20:00) before ovulation triggering in healthy oocyte donors. A flexible antagonist protocol was used, and ovarian stimulation was achieved with recombinant follicle-stimulating hormone (FSH) in all cases. The pairwise percentage differences in progesterone levels for each patient were calculated. Univariate linear regression analysis was adopted in order to evaluate variables associated with progesterone levels on the first measurement. The intra-day variability of progesterone was analysed using mixed models. MAIN RESULTS AND THE ROLE OF CHANCE Mean serum progesterone values at 08:00, 12:00, 16:00 and 20:00 were 1.75 ng/ml, 1.40 ng/ml, 1.06 ng/ml and 0.97 ng/ml. The progesterone difference between 08:00 and 20:00 was 0.77 (95% CI, 0.56–0.99), which is equivalent to a 44% decline in the mean progesterone values between the first (08:00) and the last determination (20:00; P < 0.001). Among those patients with basal (08:00) progesterone levels >1.5 ng/ml (n = 10), 70% (n = 7) showed levels reduced to <1.5 ng/ml on the last determination of the day (20:00). A mixed model analysis revealed that the progesterone reduction during the day was significantly associated with time and total recombinant FSH dose administered. LIMITATIONS, REASONS FOR CAUTION Only young healthy oocyte donors stimulated with an antagonist protocol using recombinant FSH were included. Extrapolation to the general IVF population, with different stimulation protocols and gonadotropins, needs to be confirmed. WIDER IMPLICATIONS OF THE FINDINGS This study suggests that a single progesterone determination on the final day of oocyte maturation is not reliable enough to make clinical decisions due to the enormous variation in progesterone during the day. Further studies are needed to better define the impact of the follicular progesterone rise on the endometrium of IVF cycles. STUDY FUNDING/COMPETING INTEREST(S) Funding was granted from Fundació Santiago Dexeus Font. N.P.P. received unrestricted grants and/or lectures fees from Roche Diagnostics, MSD, Merck, Ferring Pharmaceuticals, IBSA, Theramex and BESINS International, not associated with the current study. The remaining authors have no competing interests. TRIAL REGISTRATION NUMBER Clinicaltrials.gov NCT03366025.
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Rymkiewicz, Anna. « Job Satisfaction Analysis of Nurses, who Work in Neurology and Neurosurgery Units ». Journal of Neurological and Neurosurgical Nursing 11, no 3 (1 décembre 2022) : 114–23. http://dx.doi.org/10.15225/pnn.2022.11.3.3.
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Introduction. Satisfaction, facing problems and motivation are currently strategic points to be analysed in terms of nurses’ work. All positive or negative perceptions and attitudes towards work translate into commitment, identity creation, turnover and also status. The fit between the individual and the organisation draws attention. Both the complementary and supplementary dimensions show to what extent the employee’s needs are met and whether the recognised values of the two groups are the same. For the employee, this translates into identification with the workplace. A high degree of fit influences the status of the workplace, the involvement of employees in the tasks at hand increasing their quality. On the other hand, the existence of mismatches generates bad interpersonal relations, inappropriate division of responsibilities, loss of trust, and leads to conflicts.
Aim. Comparative analysis of changes in the context of sense of job satisfaction of nurses working in neurological and neurosurgical wards in the Silesian province over the last decade.
Material and Methods. The study was conducted in 2012 and 2022 among nurses working in neurological and neurosurgical wards of the N.M.P. Regional Specialist Hospital in Częstochowa and the Prof. K. Gibiński University Medical Centre in Katowice. The study used an original questionnaire containing 61 questions on various aspects of the work performed.
Results. Among the respondents, the predominant age group is over 51 years old with a master’s degree, whereas in the earlier survey it was 31–40 years old with a secondary vocational education. The survey showed that 33% more respondents felt that their job involved a lot of physical exertion. The percentage of those able to cope with complex mental tasks has decreased significantly, the percentage of nurses who are overburdened with too many tasks has increased, 75% of them notice the impact of work on family life. Professional qualifications are being improved by 40% more of those surveyed than ten years ago, but 29% are attending fewer conferences and training courses, and 24% are introducing innovations into their workplace less than in 2012. A sense of meaningfulness and usefulness of the tasks performed at work is shared by 66% of respondents, previously 91% in 2012. The impact of the ward’s equipment on the work performed is now noted by 70% more nurses, and is considered by 66% of respondents as a factor giving greater job satisfaction, a decade ago it was 86% of respondents. Nursing staffing is considered sufficient by 34% more respondents than the previous survey showed. Far fewer respondents now perceive the impact of aggressive patient behaviour on their work. The percentage of respondents noticing conflicts with doctors increased by 72%. 77% more respondents feel they are treated fairly by their superiors than a decade ago. Low social prestige of the profession is noticed by only 6% of nurses.
Conclusions. Nurses do not feel satisfaction with their work, even though they see a sense of purpose in the activities they undertake. This means that their need for development has been disrupted by low motivation both socially and economically, a sense of being undervalued and insufficient identification with the workplace. Most of the same people took part in the current survey as ten years ago, their attitude to their work has changed dramatically. Nurses are coping less well with their tasks. The work is associated with too much physical and mental strain. Relationships between nurses and patients and between nurses and other team members have changed. Nursing staffing in neurological and neurosurgical wards, where patients with severe conditions are often hospitalised, is insufficient. (JNNN 2022;11(3):114–123)
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Smith, Frederick M. « N.V.P. Unithiri, H.N. Bhat and S.A.S. Sarma : The Bhaktimandākinī. An Elaborate Fourteenth-Century Commentary by Pūrṇasarasvatī on the Viṣṇupādādikeśavastotra attributed to Śaṅkarācārya. (École française d'Extrême-Orient, Collection Indologie 118.) li, 186 pp. Pondicherry : Institut français de Pondichéry, 2011. ISBN 978 81 8470 188 3. » Bulletin of the School of Oriental and African Studies 76, no 3 (octobre 2013) : 523–25. http://dx.doi.org/10.1017/s0041977x13000669.
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Polyzos, Nikolaos P., A. R. Neves, P. Drakopoulos, C. Spits, B. Alvaro Mercadal, S. Garcia, P. Q. M. Ma et al. « The effect of polymorphisms in FSHR and FSHB genes on ovarian response : a prospective multicenter multinational study in Europe and Asia ». Human Reproduction 36, no 6 (23 avril 2021) : 1711–21. http://dx.doi.org/10.1093/humrep/deab068.
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Abstract STUDY QUESTION Does the presence of single nucleotide polymorphisms (SNPs) in the FSH receptor gene (FSHR) and/or FSH beta subunit-encoding gene (FSHB) influence ovarian response in predicted normal responders treated with rFSH? SUMMARY ANSWER The presence of FSHR SNPs (rs6165, rs6166, rs1394205) has a statistically significant impact in ovarian response, although this effect is of minimal clinical relevance in predicted normal responders treated with a fixed dose of 150 IU rFSH. WHAT IS KNOWN ALREADY Ovarian reserve markers have been a breakthrough in response prediction following ovarian stimulation. However, a significant percentage of patients show a disproportionate lower ovarian response, as compared with their actual ovarian reserve. Studies on pharmacogenetics have demonstrated a relationship between FSHR or FSHB genotyping and drug response, suggesting a potential effect of individual genetic variability on ovarian stimulation. However, evidence from these studies is inconsistent, due to the inclusion of patients with variable ovarian reserve, use of different starting gonadotropin doses, and allowance for dose adjustments during treatment. This highlights the necessity of a well-controlled prospective study in a homogenous population treated with the same fixed protocol. STUDY DESIGN, SIZE, DURATION We conducted a multicenter multinational prospective study, including 368 patients from Vietnam, Belgium, and Spain (168 from Europe and 200 from Asia), from November 2016 until June 2019. All patients underwent ovarian stimulation followed by oocyte retrieval in an antagonist protocol with a fixed daily dose of 150 IU rFSH until triggering. Blood sampling and DNA extraction was performed prior to oocyte retrieval, followed by genotyping of four SNPs from FSHR (rs6165, rs6166, rs1394205) and FSHB (rs10835638). PARTICIPANTS/MATERIALS, SETTING, METHODS Eligible were predicted normal responder women <38 years old undergoing their first or second ovarian stimulation cycle. Laboratory staff and clinicians were blinded to the clinical results and genotyping, respectively. The prevalence of hypo-responders, the number of oocytes retrieved, the follicular output rate (FORT), and the follicle to oocyte index (FOI) were compared between different FSHR and FSHB SNPs genotypes. MAIN RESULTS AND THE ROLE OF CHANCE The prevalence of derived allele homozygous SNPs in the FSHR was rs6166 (genotype G/G) 15.8%, rs6165 (genotype G/G) 34.8%, and rs1394205 (genotype A/A) 14.1%, with significant differences between Caucasian and Asian women (P < 0.001). FSHB variant rs10835638 (c.-211 G>T) was very rare (0.5%). Genetic model analysis revealed that the presence of the G allele in FSHR variant rs6166 resulted in less oocytes retrieved when compared to the AA genotype (13.54 ± 0.46 vs 14.81 ± 0.61, estimated mean difference (EMD) −1.47 (95% CI −2.82 to −0.11)). In FSHR variant rs1394205, a significantly lower number of oocytes was retrieved in patients with an A allele when compared to G/G (13.33 ± 0.41 vs 15.06 ± 0.68, EMD −1.69 (95% CI −3.06 to −0.31)). A significantly higher prevalence of hypo-responders was found in patients with the genotype A/G for FSHR variant rs6166 (55.9%, n = 57) when compared to A/A (28.4%, n = 29), ORadj 1.87 (95% CI 1.08–3.24). No significant differences were found regarding the FORT across the genotypes for FSHR variants rs6166, rs6165, or rs1394205. Regarding the FOI, the presence of the G allele for FSHR variant rs6166 resulted in a lower FOI when compared to the A/A genotype, EMD −13.47 (95% CI −22.69 to −4.24). Regarding FSHR variant rs6165, a lower FOI was reported for genotype A/G (79.75 ± 3.35) when compared to genotype A/A (92.08 ± 6.23), EMD −13.81 (95% CI −25.41 to −2.21). LIMITATIONS, REASONS FOR CAUTION The study was performed in relatively young women with normal ovarian reserve to eliminate biases related to age-related fertility decline; thus, caution is needed when extrapolating results to older populations. In addition, no analysis was performed for FSHB variant rs10835638 due to the very low prevalence of the genotype T/T (n = 2). WIDER IMPLICATIONS OF THE FINDINGS Based on our results, genotyping FSHR SNPs rs6165, rs6166, rs1394205, and FSHB SNP rs10835638 prior to initiating an ovarian stimulation with rFSH in predicted normal responders should not be recommended, taking into account the minimal clinical impact of such information in this population. Future research may focus on other populations and other genes related to folliculogenesis or steroidogenesis. STUDY FUNDING/COMPETING INTEREST(S) This study was supported by an unrestricted grant by Merck Sharp & Dohme (MSD). N.P.P. reports grants and/or personal fees from MSD, Merck Serono, Roche Diagnostics, Ferring International, Besins Healthcare, Gedeon Richter, Theramex, and Institut Biochimique SA (IBSA). N.L.V. and M.T.H. report consultancy and conference fees from Merck, Ferring, and MSD, outside the submitted work. P.D. has received honoraria for lecturing and/or research grants from MSD, Ferring International, and Merck. D.S. reports grants and/or personal fees from MSD, Ferring International, Merck Serono, Cook, and Gedeon Richter. A.R.N., B.A.M., C.S., J.M., L.H.L., P.Q.M.M., H.T., and S.G. report no conflict of interests. TRIAL REGISTRATION NUMBER NCT03007043
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Edralin, Divina, et Ronald Pastrana. « Sustainability Reporting of Leading Global Universities in Asia, Europe, and USA ». Bedan Research Journal 4, no 1 (30 avril 2019) : 24–45. http://dx.doi.org/10.58870/berj.v4i1.2.
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Sustainable development as a concept is a significant landmark in the environmental theory because it hypothesizes on how society itself should be organized, and not merely on why certain environmental safeguards should be embraced or how they can be best applied. Our study determined the sustainability reporting of selected leading global universities in Asia, Europe, and the USA. Using the descriptive and comparative research designs, fifteen higher educational institutions from leading global universities with business schools and institutional sustainability development programs were used as sample cases. Based on the universities’ published Sustainability Reports, several patterns of sustainability reporting practices appeared to be being used. Results revealed that all the sampled universities in Asia, Europe, and USA publish their Stand-Alone Sustainability Reports annually, as well as publish parts of their sustainability performance in their Annual Reports at the end of every academic year. These reports are made available in their websites year-round. Findings also showed that in terms of reporting framework, the universally recognized Global Reporting Initiative is predominantly used by universities in Asia and Europe, followed by the Environmental Management System certifiable under ISO 14001 standards. USA universities, however, use a combination of standards, some not formal, but patterned it after the models such as the UN Global Standards, Corporate Knights, International Sustainability Campus Network/GULF Framework, and People and Planet Green League. Among the four priority concerns on sustainability reporting, environmental indicators obtained the highest average frequency; followed by governance, social, and economic indicators among the three regions, led by Europe and US universities. Overall, the level of sustainability disclosure is high in all the four indicators, and it is highest among European universities, followed by US universities, and then by Asian universities. We recommend that Philippine universities benchmark their sustainability reporting practices in the manner by which leading global universities practice them. ReferencesBlessing, L. (2009). The changing tole of universities in the knowledge. In The knowledge triangle shaping the future of Europe: Summary report from the conference (pp.19-21) Göteborg, Sweden: Högskoleverket (Swedish National Agency for Higher Education).Carayannis, E., Barth, T., & Campbell, D. (2012). The Quintuple Helix innovation model: global warming as a challenge and driver for innovation. Journal of Innovation and Entrepreneurship, 1(1), 2. doi:10.1186/2192-5372-1-2Commission on Higher Education (2014). Handbook on Institutional Sustainability Assessment, Philippines. Retrieved from https://ched.gov.ph/programs-and-projects/Commission on Higher Education (2012). Policies, standards and guidelines on outcomes-based education and typology-based Quality Assurance System for Philippine Higher Education Institutions (Commission on Higher Education Memorandum Order 46, Series 2012). Retrieved from https://ched.gov.ph/programs-and-projects/Commission of the European Communities. (2006). Delivering on the modernisation agenda for universities: Education, research and innovation. Communication from the commission to the council and the European Parliament. COM(2006) 208 final, 10 May. Brussels: European Union.COPERNICUS Alliance. (2012). Rio +20 people’s sustainability treaty on higher education. Retrieved from https://www.iucn.org/content/rio20-peoples-sustainabilitytreaty-higher-educationElkington, J. (2018, June 25). 25 years ago, I coined the phrase “triple bottom line.” Here’s why it’s time to rethink it. Harvard Business Review. Retrieved from https://hbr.org/2018/06/25-years-ago-i-coined-the-phrase-triple-bottom-line-heres-whyim-giving-up-on-it.Ercoskun, O. (2005). Sustainable city plans against development plans. Journal of Science, 18(3). Retrieved from https://www.gujs.gazi.edu.tr/articleview.Flodström, A. (2009). The knowledge triangle shaping the future of Europe – Conference Conclusions. In The knowledge triangle shaping the future of Europe: Summary report from the conference (pp.7-9) Göteborg, Sweden: Högskoleverket (Swedish National Agency for Higher Education).Global Reporting Initiative (GRI) (2013a). G4 sustainability reporting guidelines: Reporting principles and standard disclosures. Retrieved from https://www.globalreporting.org/Holmberg, J. (2014). Transformative learning and leadership for a sustainable future: Challenge Lab at Chalmers University of Technology. In P. B. Corcoran, B. P. Hollingshead, H. Lotz-Sisitka, A. E. J. Wals, & J. P. Weakland (Eds.), Intergenerational learning and transformative leadership for sustainable futures (pp. 91–102). The Netherlands: Wageningen Academic Publishers. Retrieved fromhttp://www.wageningenacademic.com/doi/pdf/10.3920/978-90-8686-802-5_4Kolukisa, A. & Ugurlu, N. (2019). The importance of sustainable development in the field of education introduction. Research Gate. Retrieved from https://www.researchgate.net/publication/265030253.Lappalainen, P., & Markkula, M. (Eds.). (2013). The knowledge triangle: Re-inventing the future. Finland: European Society for Engineering Education (SEFI), Aalto University, & Universitat Politecnica de Valencia.Loh, L., Thao, N.T.P., Sim, I., Thomas, T., & Yu, W. (2016). Sustainability reporting in ASEAN: State of progress in Indonesia, Malaysia, Singapore and Thailand 2015. Singapore: ASEAN CSR Network.Mendoza, D. and Terpous, K. (2014). Sustainability reporting in universities [Blue Paper Report]. Sweden: Chalmers-Innovationskontor VAST. Retrieved from https://innovationskontor.chalmers.se/sites/innovationskontoret.cms.chalmers.se/files/BURR-1.0-2014.pdfSaunders, M., Lewis, P., & Thornhill, A. (2015). Research methods for business students (7th Ed.), Harlow, UK: Pearson Education Ltd.Schruumanns, M. (2009). In The knowledge triangle shaping the future of Europe: Summary report from the conference (pp. 15-16) Göteborg, Sweden: Högskoleverket (Swedish National Agency for Higher Education).Sorlin, S. (2009). How universities can take on increasing societal demands and remain powerhouses of intellectual freedom. In The knowledge triangle shaping the future of Europe: Summary report from the conference (pp.24-30) Göteborg, Sweden: Högskoleverket (Swedish National Agency for Higher Education).Taylor, J. R. (2002). Conceptual approaches v: Concepts and domains. In A. D. Cruse, F. Hundsnurscher, M. Job, & P. R. Lutzeier (Eds.), Lexikologie - Lexicology. An international handbook on the nature and structure of words and vocabularies, Vol. 1 (pp. 296-303). Berlin and New York: Walter de Gruyter. Retrieved from https://www.academia.edu/6098913/Taylor_2002_Concepts_and_domainsUnited Nations Educational Scientific and Cultural Organization (UNESCO). (2005). UN Decade of Education for Sustainable Development 2005 - 2014. Retrieved from https://unesdoc.unesco.org/ark:/48223/pf0000141629Vitalis, V. (2003). Sustainable Development. Keynote Paper presented to the Research School for the Socio-Economic and Natural Sciences of the Environment (SENSE) Summer Symposium 19-20 June 2003, Amsterdam, Netherlands. Organisation de Coopération et de Développement Economiques.World Commission on Environment and Development / Brundtland Commission (1987). Report of the World Commission on Environment and Development: Our common future. Oxford: Oxford University Press.
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Vinh, Pham Quang, Nguyen Thi Thu Ha, Nguyen Thanh Binh, Nguyen Ngoc Thang, La Thi Oanh et Nguyen Thien Phuong Thao. « Developing algorithm for estimating chlorophyll-a concentration in the Thac Ba Reservoir surface water using Landsat 8 Imagery ». VIETNAM JOURNAL OF EARTH SCIENCES 41, no 1 (8 janvier 2019) : 10–20. http://dx.doi.org/10.15625/0866-7187/41/1/13542.
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This study aims at developing a regional algorithm to quantify chlorophyll-a concentration (Chla) in the Thac Ba Reservoir surface-water using Landsat 8 imagery basing on in-situ data of Chla and above-water reflectance taken in both dry and rainy seasons 2018. In situ datasets obtained from 30 water sampling sites show a strong correlation (R2=0.73) with the reflectance ratio of two Landsat 8 (L8) bands, the green band (band 3: B3) versus the red band (band 4: B4), B3 / B4, by an exponential equation. The algorithm for estimating Chla using this ratio was well-matched up the validation using multiple-dates in-situ datasets (R2 = 0.82; RMSE ~ 5%) and was then applied to L8 images level 2 acquired in both dry and rainy seasons to understand the spatiotemporal distribution of Chla over the reservoir. Obtained maps of Chla present clearly two trends: (1) Chla in the reservoir water in the dry season (averaged at 15.3 mg/m3) is relatively lower than those in the rainy season (averaged at 17.0 mg/m3); (2) In both seasons, Chla increased from water area in front of the Chay River mouth to the center of the reservoir. The algorithm and method outlined in this study could be applied to monitoring Chl in other inland waters having similar features as the Thac Ba Reservoir water.ReferencesAPHA, 1998. Standard Methods for the Examination of Water and Wastewater, 20th edition. American Public Health Association, Washington DC, 1220p.Bac N.A., Viet N.D., Ha N.T.T., Huong H.T.T., 2017. Identifying eutrophication status of shallow waters based on estimated trophic state index from satellite data. Journal of Science and Technology, 55(4C), 85-89.Bernardo N., Watanabe F., Rodrigues T., Alcântara E., 2017. Atmospheric correction issues for retrieving total suspended matter concentrations in inland waters using OLI/Landsat-8 image. Advances in Space Research, 59(9), 2335-2348.Boucher J., Weathers K.C., Norouzi H., Steele B., 2018. Assessing the effectiveness of Landsat 8 chlorophyll a retrieval algorithms for regional freshwater monitoring. Ecological Applications, 28(4), 1044-1054.Carlson R.E., 1977. A trophic state index for lakes1. Limnology and oceanography, 22(2), 361-369.Carlson R.E., Simpson J., 1996. A coordinator’s guide to volunteer lake monitoring methods. North American Lake Management Society, 96, 305.DWR - Directorate of Water Resource, 2017. Report on weather conditions, water supplies, flood control and irrigations security No. 49/BC-TCTL-QLCT to Minister of Agriculture and Rural Development (in Vietnamese) on October 16th, Hanoi, Vietnam. Gholizadeh M.H., Melesse A.M., Reddi L., 2016. A comprehensive review on water quality parameters estimation using remote sensing techniques. Sensors, 16(8), 1298.Gitelson A., Stark R., Oron G., Dor I., 1997. Monitoring of polluted water bodies by remote sensing. IAHS Publications-Series of Proceedings and Reports-Intern Assoc Hydrological Sciences, 242, 181-188.Ha N.T.T., Koike K., 2011. Integrating satellite imagery and geostatistics of point samples for monitoring spatio-temporal changes of total suspended solids in bay waters: application to Tien Yen Bay (Northern Vietnam). Frontiers of Earth Science, 5(3), 305.Kutser T., 2009. Passive optical remote sensing of cyanobacteria and other intense phytoplankton blooms in coastal and inland waters. International Journal of Remote Sensing, 30(17), 4401-4425.Kutser T., 2012. The possibility of using the Landsat image archive for monitoring long time trends in coloured dissolved organic matter concentration in lake waters. Remote Sensing of Environment, 123, 334-338.Michelutti N., Blais J.M., Cumming B.F., Paterson A.M., Rühland K., Wolfe A.P., Smol J.P., 2010. Do spectrally inferred determinations of chlorophyll a reflect trends in lake trophic status?. Journal of Paleolimnology, 43(2), 205-217.Mobley C.D., 1999. Estimation of the remote-sensing reflectance from above-surface measurements. Applied Optics, 38(36), 7442-7455.Nhung P.T., Canh B.D., Ha N.T.T., Linh N.T., 2016. Modeling spatial-temporal distribution of total suspended solids concentrations in Day Estuary water using Landsat 8 Imagery. Proceeding of the 7th International Symposium Hanoi Geoengineering 2016 on Energy and Sustainability, Hanoi, October 21-22, 69-75.Olmanson L.G., Bauer M.E., Brezonik P.L., 2008. A 20-year Landsat water clarity census of Minnesota's 10,000 lakes. Remote Sensing of Environment, 112(11), 4086-4097.Padisák J., Borics G., Grigorszky I., Soroczki-Pinter E., 2006. Use of phytoplankton assemblages for monitoring ecological status of lakes within the Water Framework Directive: the assemblage index. Hydrobiologia, 553(1), 1-14.Palmer S.C., Kutser T., Hunter P.D., 2015. Remote sensing of inland waters: Challenges, progress and future directions. Remote Sens. of Environ. Special Issue: Remote Sensing of Inland Waters, 157(1), 1-8.Quang N.H., Sasaki J., Higa H., Huan N.H., 2017. Spatiotemporal Variation of Turbidity Based on Landsat 8 OLI in Cam Ranh Bay and Thuy Trieu Lagoon, Vietnam. Water, 9(8), 570.Son N.H., Anh B.T, Thuy N.T.T, 2000. Investigation of the Fisheries in Farmer-Managed Small Reservoir in Thai Nguyen and Yen Bai Province. Proceedings of an International Workshop on Reservoir and Culture-based Fisheries: Biology and Management. Bangkok, Thailand 15-18 February, 246-257.Tebbs E.J., Remedios J.J., Harper D.M., 2013. Remote sensing of chlorophyll-a as a measure of cyanobacterial biomass in Lake Bogoria, a hypertrophic, saline-alkaline, flamingo lake, using Landsat ETM+. Remote Sensing of Environment, 135, 92-106.Thuy D.B., Canh B.D., Ha N.T.T., Thao N.T.P., Nhi B.T., 2016. Modeling spatial distribution of total suspended solids concentration in Ha Long Bay water during the first quarter of 2016 using co-kriging interpolation and auxiliary data from Landsat 8 imagery. Proceeding of the 7th International Symposium Hanoi Geoengineering 2016 on Energy and Sustainability, Hanoi, October 21-22, 148-153.Tiwari S.P., Shanmugam P., Ahn Y.H., Ryu J.H., 2012. A Reflectance Model for Relatively Clear and Turbid Waters. Engineering, Technology & Applied Science Research, 3(1), 325-337.UNEP, 2014. Review of existing water quality guidelines for freshwater ecosystems and application of water quality guidelines on basin level to protect ecosystems. Technical background document for theme 1: “Water Quality and Ecosystem Health”. First International Environment Forum for Basin Organizations towards Sustainable Freshwater Governance, 26-28 November 2014, Nairobi, Kenya.US Environmental Protection Agency, 2009. National lakes assessment: a collaborative survey of the nation's lakes, 103p.Vermote E., Justice C., Claverie M., Franch B., 2016. Preliminary analysis of the performance of the Landsat 8/OLI land surface reflectance product. Remote Sensing of Environment, 185, 46-56.Watanabe F., Alcantara E., Rodrigues T., Rotta L., Bernardo N., Imai N., 2018. Remote sensing of the chlorophyll-a based on OLI/Landsat-8 and MSI/Sentinel-2A (Barra Bonita reservoir, Brazil). Anais da Academia Brasileira de Ciências, 90(2), 1987-2000.Yang Z., Anderson Y., 2016. Estimating chlorophyll-a concentration in a freshwater lake using Landsat 8 Imagery. J. Environ. Earth Sci., 6(4), 134-142.
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Phillips, Natalie A., John F. Connolly, C. Charles Mate-Kole et John Gray. « Individual differences in auditory middle latency responses in elderly adults and patients with Alzheimer's disease1A preliminary report of these data was presented at the Tenth International Conference on Event-Related Potentials of the Brain (EPIC X), in Eger, Hungary, June, 1992. This work was supported by the Scottish Rite Charitable Foundation of Canada (N.A.P.) and grants from the Canadian Psychiatric Research Foundation and the Dalhousie University Department of Psychiatry (J.F.C.). The first author was supported by a Natural Sciences and Engineering Council of Canada (NSERC) Graduate Fellowship.1 ». International Journal of Psychophysiology 27, no 2 (septembre 1997) : 125–36. http://dx.doi.org/10.1016/s0167-8760(97)00051-2.
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« N.B.S. parallel computer benchmark collection ». Pattern Recognition 19, no 3 (janvier 1986) : 247. http://dx.doi.org/10.1016/0031-3203(86)90015-4.
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« 97/01236 New approach to the decay ratio estimation in B.W.R. N.P.P. : frequency-moments technique ». Fuel and Energy Abstracts 38, no 2 (mars 1997) : 99. http://dx.doi.org/10.1016/s0140-6701(97)83011-1.
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Sreepadapu, Rajkumar, et Swathi Polasa. « An Overview of Application for N.B.A Accreditation to Diploma Level Polytechnic Institutions in India and Advantages ». IARJSET 8, no 9 (30 septembre 2021). http://dx.doi.org/10.17148/iarjset.2021.8916.
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Mauricio Villarrial, Ronal Alex, et Marlon Gaston Farfan Cordova. « STRUCTURAL CONCRETE MODIFIED WITH SCALLOP SHELL LIME ». Revista Ingeniería de Construcción 36, no 3 (2021). http://dx.doi.org/10.7764/ric.00010.21.
Texte intégralRésumé :
This research was conducted to determine the effect of the scallop shell lime (SSL) on the compressive strength of concrete made with Portland cement type Ico and natural aggregates from a quarry, where SSL was added at 3%, 4% and 5%. The physical and mechanical characteristics of the aggregates were determined based on the N.T.P. 400.037/ASTM C22 standard, and the mix design was carried out through the ACI method. The SSL was used due to the high calcium content present in the valve. Standard concrete controls were prepared and cured by adding 3%, 4% and 5% SSL (339.0183/ASTM C192M), which were analyzed at 7, 14 and 28 days of curing. The results showed that the compressive strength at 28 days was 242.63 kg/cm2 when 3% SSL was added, increasing with respect to the standard control by 16%. With the addition of 4% SSL, the maximum strength reached was 245.25 kg/cm2, and with 5%, the compressive strength reached was 261.17 kg/cm2, increasing by 24%. In conclusion, the SSL positively affects the increase of concrete strength, and the percentage with the highest incidence is 5%.
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Tait, Noel N., Ivo de Sena Oliveira et Georg Mayer. « Translation of N.B.K. Sänger’s (1871) “Peripatus capensis Gr. and Peripatus leuckartii n. sp.” (Onychophora), along with remarks about the author and significance of his work ». Australian Zoologist, 4 août 2021. http://dx.doi.org/10.7882/az.2021.022.
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ABSTRACT The basic biology of onychophorans was revealed slowly and controversially during much of the 19th century. Communications were in Latin, French, Spanish, German and English. This information was synthesised in the monumental monographs of Bouvier in 1905 and 1907. However, amongst this multicultural endeavour is a significant Russian contribution by Nikolai Sänger, a student of Professor Leuckart of the Zoological Institute in Leipzig, Germany. Sänger requested a specimen of Onychophora from the Institute’s collection for serial sectioning. This resulted in a detailed account of the anatomy of Peripatopsis capensis. Sänger’s description of the extensive slime glands was the first to recognise them as the hallmark of onychophorans for defence and prey capture, and not the male reproductive system as previously claimed. Based on these morphological observations, he correctly concluded that onychophorans are not hermaphrodites and, furthermore, are “predominantly predaceous” animals. He further appropriately assigned the slime glands and salivary glands to the slime papilla segment, despite the lack of embryological data at that time. Sänger also identified the excretory organs (nephridia) and their openings, although he erroneously assigned them to a dual role of excretion and respiration. Moreover, he highlighted the importance of the position of the genital opening as a diagnostic character, described the ventral/preventral organs as “subcutaneous glandules”, identified the neurilemma enclosing the central nervous system, and recognised “oval holes of different sizes” in each nerve cord that were subsequently demonstrated to represent giant fibres. Of interest to parasitologists, he discovered a larval acanthocephalan encysted within the cutaneous muscles of his specimen of P. capensis, suggesting that onychophorans act as a secondary host for this parasite. Sänger’s memoir concludes with a brief but important description of the first species of Onychophora recorded from Australia, “northwest of Sydney, New Holland”. This species is now known as Euperipatoides leuckartii with a neotype designated from a specific location northwest of Sydney.
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Thi Xuan, Bui, Bui Thi Thu Hoai et Le Thi Lan Huong. « The Reality of Medicine Use in the Department of Tropical Diseases at E hospital from 10/2019 to 3/2020 ». VNU Journal of Science : Medical and Pharmaceutical Sciences 36, no 4 (19 décembre 2020). http://dx.doi.org/10.25073/2588-1132/vnumps.4235.
Texte intégralRésumé :
This paper analyzes the use of medicines in the Department of Tropical Diseases at E Hospital. The analysis shows that 100% of the medical records were completely and clearly filled out with the patient’s name, age, gender, address and clear information about the medicines, their concentrations and routes of administration. However, there were some deficiencies in administrative procedures, such as 7.75% of the medical records abbreviated the main diagnosis, 94.75% of them did not prescribe medicines according to their routes of administration. The average number of medicines per person per day was 5.04 and the average treatment time was 5.85 days. Notably, the percentage of the medical records with prescription of injectable medicines was remarkably high (98.75%).
Keywords
Medicine use, Department of Tropical Diseases, E hospital.
References
[1] N.T.T. Thuy, Analysis of the situation of medicines prescription for inpatient treatment at Military Medical Hospital 105 - General Logistics Department 2015, Specialized thesis I, 2015 (in Vietnamese).[2] N.T.P. Thuy, Analysis of of the situation of medicines prescriptions at the National Maternity Hospital in 2014, Master's thesis in pharmacy, 2015 (in Vietnamese).[3] M.A. Ghaleb, N. Barber, B. Dean Franklin & I.C. Wong, What constitutes a prescribing error in paediatrics?, Qual Saf Health Care 14 (5) (2005) pp 352-357.[4] L.T. Duc, Analysis of medicines situation at Quang Nam Central General Hospital in 2013, Specialized thesis II, 2015 (in Vietnamese).[5] V.T. Sy, Analysis of the situation of medicines prescription at Ha Tinh General Hospital in 2016, Specialized thesis II, 2018 (in Vietnamese).[6] H.T.K. Dung, Analysis of medicines situation at Thai Nguyen Hospital C in 2014, Master's thesis in pharmacy, 2015 (in Vietnamese).[7] L.T.M. Hanh, Analysis of medicines indications for inpatient treatment at Nghe An General Hospital in 2015, Specialized thesis I, 2016 (in Vietnamese).[8] L.A. Tinh , Analysis of medicines situation for inpatient treatment at Huu Nghi - Nghe An General Hosptal in 2015, Specialized thesis I, 2015 (in Vietnamese).[9] P.L. Son, Analysis of the situation of the health insurance drug payment status , Pharmacy journal, vol 428 (2012) pp 12-16. (in Vietnamese).
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Hum, Ryan M., James B. Lilleker, Janine A. Lamb, William E. Ollier, Guochung Wang, Lucy R. Wedderburn, Louise P. Diederichsen et al. « P222 Clinical features of extra-muscular disease in dermatomyositis and anti-synthetase syndrome patients with skin involvement classified by presence of disease-specific autoantibodies : results from the EuroMyositis registry ». Rheumatology 61, Supplement_1 (23 avril 2022). http://dx.doi.org/10.1093/rheumatology/keac133.221.
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Abstract Background/Aims Anti-synthetase syndrome (ASS) represents a distinct entity within myositis spectrum disorders; however, correct classification of patients with anti-tRNA synthetase autoantibodies and skin manifestations akin to dermatomyositis (DM) remains uncertain. Our aim was to compare clinical characteristics, skin involvement, and malignancy, between patients with ASS and DM, classified by disease-specific autoantibodies. Methods Data from 05/2009-03/2016 from 9 countries from the prospective, myositis EuroMyositis registry were downloaded. Those with anti-tRNA synthetase autoantibodies (Jo-1/PL-7/PL-12/OJ/EJ/KS) were classified as ASS, and those with Mi-2/TIF1-γ/NXP2/SAE/MDA5 autoantibodies as DM. Clinical phenotypes including malignancies (except skin malignancies) were tabulated. Characteristics of patients with skin involvement (excluding mechanic’s hands and Raynaud’s phenomenon) were compared using Fisher’s exact test with Bonferroni corrected p-values. Results Of 3,067 patients, 2,028 had autoantibody profiling results (66.1%), of which 783 (38.6%) were positive for at least one of the autoantibodies being considered. Five patients with dual autoantibody specificities were excluded. Of the remaining 778, 320 (41.1%) were classified as DM, and 458 (58.9%) as ASS. Median age at diagnosis was 48.2 years (interquartile range [IQR] 37.5 to 57.8) in the DM cohort and 49 (IQR 38.3 to 62.2) in the ASS cohort. Skin involvement was present in 277 (86.6%) DM patients (DM skin) vs 204 (44.5%) ASS patients (ASS skin) (pcorr<0.01) (Table 1). Whilst relatively high proportions of so-called “DM-specific” rashes were seen in ASS skin, the frequency of heliotrope rash, Gottron’s papules, violaceous rash, periorbital rash, V-sign, shawl sign, and periungual erythema was significantly higher in DM skin (pcorr<0.01 for all). Conversely, mechanic’s hands, Raynaud’s, arthritis, and interstitial lung disease were more frequent in ASS skin (pcorr<0.01 for all). Malignancy was less frequent in ASS skin vs DM skin (pcorr<0.01) and occurred temporally closer to myositis diagnosis in DM skin (median 0.95 months [IQR -6.54. to 19.45]) vs ASS skin (median 12.17 months [IQR -15.85 to 79.31]). Conclusion Patients with ASS have frequent skin involvement but also a distinct clinical phenotype compared to DM. These findings may inform the development of future classification criteria for ASS. Disclosure R.M. Hum: None. J.B. Lilleker: None. J.A. Lamb: None. W.E. Ollier: None. G. Wang: None. L.R. Wedderburn: None. L.P. Diederichsen: None. J. Schmidt: None. P. Oakley: None. O. Benveniste: None. M.G. Danieli: None. K. Danko: None. N.T.P. Thuy: None. M.V.D. Mercado: None. H. Andersson: None. B.D. Paepe: None. J.L.D. Bleecker: None. B. Maurer: None. L.J. McCann: None. N. Pipitone: None. N. McHugh: None. P. New: None. J. Vencovsky: None. I.E. Lundberg: None. H. Chinoy: None.
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Neves, A. R., N. L. Vuong, C. Blockeel, S. Garcia, C. Alviggi, C. Spits, P. Q. M. Ma, M. T. Ho, H. Tournaye et N. P. Polyzos. « The effect of polymorphisms in FSHR gene on late follicular phase progesterone and estradiol serum levels in predicted normoresponders ». Human Reproduction, 7 septembre 2022. http://dx.doi.org/10.1093/humrep/deac193.
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Abstract STUDY QUESTION Does the presence of FSHR single-nucleotide polymorphisms (SNPs) affect late follicular phase progesterone and estradiol serum levels in predicted normoresponders treated with rFSH? SUMMARY ANSWER The presence of FSHR SNPs (rs6165, rs6166, rs1394205) had no clinically significant impact on late follicular phase serum progesterone and estradiol levels in predicted normoresponders undergoing a GnRH antagonist protocol with a fixed daily dose of 150 IU rFSH. WHAT IS KNOWN ALREADY Previous studies have shown that late follicular phase serum progesterone and estradiol levels are significantly correlated with the magnitude of ovarian response. Several authors have proposed that individual variability in the response to ovarian stimulation (OS) could be explained by variants in FSHR. However, so far, the literature is scarce on the influence of this genetic variability on late follicular phase steroidogenic response. Our aim is to determine whether genetic variants in the FSHR gene could modulate late follicular phase serum progesterone and estradiol levels. STUDY DESIGN, SIZE, DURATION In this multicenter multinational prospective study conducted from November 2016 to June 2019, 366 patients from Vietnam, Belgium and Spain (166 from Europe and 200 from Asia) underwent OS followed by oocyte retrieval in a GnRH antagonist protocol with a fixed daily dose of 150 IU rFSH. All patients were genotyped for 3 FSHR SNPs (rs6165, rs6166, rs1394205) and had a serum progesterone and estradiol measurement on the day of trigger. PARTICIPANTS/MATERIALS, SETTING, METHODS Included patients were predicted normal responder women <38 years old undergoing their first or second OS cycle. The prevalence of late follicular phase progesterone elevation (PE), as well as mean serum progesterone and estradiol levels on the day of trigger were compared between the different FSHR SNPs genotypes. PE was defined as >1.50 ng/ml. MAIN RESULTS AND THE ROLE OF CHANCE The overall prevalence of PE was 15.8% (n = 58). No significant difference was found in the prevalence of PE in Caucasian and Asian patients (17.5% versus 14.5%). Estradiol levels on the day of trigger and the number of retrieved oocytes were significantly higher in patients with PE (4779 ± 6236.2 versus 3261 ± 3974.5 pg/ml, P = 0.003, and 16.1 ± 8.02 versus 13.5 ± 6.66, P = 0.011, respectively). Genetic model analysis, adjusted for patient age, body mass index, number of retrieved oocytes and continent (Asia versus Europe), revealed a similar prevalence of PE in co-dominant, dominant and recessive models for variants FSHR rs6166, rs6165 and rs1394205. No statistically significant difference was observed in the mean late follicular phase progesterone serum levels according to the genotypes of FSHR rs6166 (P = 0.941), rs6165 (P = 0.637) and rs1394205 (P = 0.114) in the bivariate analysis. Also, no difference was found in the genetic model analysis regarding mean late follicular phase progesterone levels across the different genotypes. Genetic model analysis has also revealed no statistically significant difference regarding mean estradiol levels on the day of trigger in co-dominant, dominant and recessive models for variants FSHR rs6166, rs6165 and rs1394205. Haplotype analysis revealed a statistically significant lower estradiol level on the day of trigger for rs6166/rs6165 haplotypes GA, AA and GG when compared to AG (respectively, estimated mean difference (EMD) −441.46 pg/ml (95% CI −442.47; −440.45), EMD −673.46 pg/ml (95% CI −674.26; −672.67) and EMD −582.10 pg/ml (95% CI −584.92; −579.28)). No statistically significant differences were found regarding the prevalence of PE nor late follicular phase progesterone levels according to rs6166/rs6165 haplotypes. LIMITATIONS, REASONS FOR CAUTION Results refer to a population of predicted normal responders treated with a normal/low fixed dose of 150 IU rFSH throughout the whole OS. Consequently, caution is needed before generalizing our results to all patient categories. WIDER IMPLICATIONS OF THE FINDINGS Based on our results, FSHR SNPs rs6165, rs6166 and rs1394205 do not have any clinically significant impact neither on late follicular phase serum progesterone nor on estradiol levels in predicted normal responders. These findings add to the controversy in the literature regarding the impact of individual genetic susceptibility in response to OS in this population. STUDY FUNDING/COMPETING INTEREST(S) This study was supported by an unrestricted grant by Merck Sharp & Dohme (MSD, IISP56222). N.P.P. reports grants and/or personal fees from MSD, Merck Serono, Roche Diagnostics, Ferring International, Besins Healthcare, Gedeon Richter, Organon, Theramex and Institut Biochimique SA (IBSA). C.A. reports conference fees from Merck Serono, Medea and Event Planet. A.R.N., C.B., C.S., P.Q.M.M., H.T., C.B., N.L.V., M.T.H. and S.G. report no conflict of interests related to the content of this article. TRIAL REGISTRATION NUMBER NCT03007043.