Thèses sur le sujet « Murine T Cells »
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Paun, Andrea. « Regulator T cells in murine AIDS ». University of Western Australia. Microbiology and Immunology Discipline Group, 2005. http://theses.library.uwa.edu.au/adt-WU2005.0115.
Texte intégralPodrebarac, Theresa A. « CD1 restricted recognition by murine T cells ». Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp01/MQ46602.pdf.
Texte intégralHughes, Jane Patricia. « Molecular regulation of apoptosis in immature murine T-cells ». Thesis, Keele University, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.301341.
Texte intégralBelfrage, Hans. « Activation of murine cytotoxic cells with interleukin-2 and the bacterial superantigen staphylococcal enterotoxin A ». Lund : Dept. of Cell & ; Molecular Biology, Section of Tumor Immunology, the Wallenberg Laboratory, 1996. http://catalog.hathitrust.org/api/volumes/oclc/38037867.html.
Texte intégralGarefalaki, Anna. « Identification of regulatory regions that determine expression of murine CD8 locus ». Thesis, University College London (University of London), 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.250198.
Texte intégralChan, Agnes How-Ching. « Purification, biochemical analysis and sequencing of a novel murine T suppressor factor ». Thesis, University of British Columbia, 1988. http://hdl.handle.net/2429/28638.
Texte intégralScience, Faculty of
Microbiology and Immunology, Department of
Graduate
Tomkins, Paul Thomas. « Interferon modulation of T-cell responses to Semliki Forest virus infected murine brain cells ». Thesis, University of Warwick, 1989. http://wrap.warwick.ac.uk/101165/.
Texte intégralChan, Po-Ying. « Characterization and cDNA cloning of a novel murine T cell surface antigen YE1/48 ». Thesis, University of British Columbia, 1988. http://hdl.handle.net/2429/28640.
Texte intégralScience, Faculty of
Microbiology and Immunology, Department of
Graduate
Rovis, Flavia. « Functional and molecular characterisation of murine CD4+CD25+ regulatory T cells ». Thesis, Imperial College London, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.486557.
Texte intégralCiurkiewicz, Małgorzata [Verfasser]. « Role of regulatory T cells, cytotoxic T cells and interleukin-10 in Theiler's murine encephalomyelitis virus infection / Małgorzata Ciurkiewicz ». Hannover : Stiftung Tierärztliche Hochschule Hannover, 2019. http://d-nb.info/1193489407/34.
Texte intégralO'Hara, Geraldine. « Characterisation of tissue homing C08+ T cells in a murine cytomegalovirus model ». Thesis, University of Oxford, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.600522.
Texte intégralStanford, Marianne Michelle. « Immunoregulation in murine experimental autoimmune thyroiditis ». Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape8/PQDD_0020/MQ54961.pdf.
Texte intégralKamal, Mahine. « Parasite-induced changes in murine small intestinal paneth and intermediate cells ». Thesis, University of Nottingham, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.342599.
Texte intégralCarney, Katharine W. « Expression patterns and functional roles of amphiregulin in murine CD4+ T cells ». Thesis, Royal Veterinary College (University of London), 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.669191.
Texte intégralBabichuk, Charolyn Kim. « Transcriptional regulation of the murine granzyme B gene in cytotoxic T cells ». Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/nq22945.pdf.
Texte intégralLin, Ya-Ling. « CD4⁺/CD8⁺ T cells and macrophage-derived TNF-α in murine schistosomiasis ». Thesis, University of Cambridge, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.627622.
Texte intégralLansdell, Casey. « Characterization of Surgery-Induced Vaccine Dysfunction in a Therapeutic Murine Melanoma Model ». Thesis, Université d'Ottawa / University of Ottawa, 2016. http://hdl.handle.net/10393/34269.
Texte intégralKashyap, Mohit. « Regulation of Murine Mast Cell Homeostasis by TGF-β1 and CD4+CD25+C Regulatory T Cells ». VCU Scholars Compass, 2006. http://scholarscompass.vcu.edu/etd/950.
Texte intégralYang, Cuihong. « Regulation of autoimmune responses by dendritic cells and regulatory T cells in murine models of systemic lupus erythematosus ». View the Table of Contents & ; Abstract, 2007. http://sunzi.lib.hku.hk/hkuto/record/B39573527.
Texte intégralPattison, Mari Anne. « The effects of ageing on murine NKT cell and macrophage populations ». Thesis, University of Edinburgh, 2017. http://hdl.handle.net/1842/29559.
Texte intégralZhou, Xinghua. « Immune mechanisms in atherosclerosis : the role of T cells in murine models of atherosclerosis / ». Stockholm, 2000. http://diss.kib.ki.se/2000/91-628-4217-X/.
Texte intégralWhibley, Natasha. « The role of effector and regulatory helper T cells in a murine model of systemic Candida albicans infection ». Thesis, University of Aberdeen, 2013. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=192231.
Texte intégralWafula, Paul Ojiambo. « Regulatory T cells, their role and mechanism of fetal protection in a pregnancy murine model / ». Berlin : Köster, 2009. http://d-nb.info/996421742/04.
Texte intégralYang, Cuihong, et 楊翠紅. « Regulation of autoimmune responses by dendritic cells and regulatory Tcells in murine models of systemic lupus erythematosus ». Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B39707362.
Texte intégralTaylor, Peter Charles. « A study of autoimmune arthritis using xenografts of human immune cells and allografts of murine immune cells into mice with severe combined immunodeficiency ». Thesis, Imperial College London, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.338516.
Texte intégralNorrie, Andrew. « Characterization of the Immune Stimulated Release of Extracellular Vesicles from Murine Cells ». Thesis, Université d'Ottawa / University of Ottawa, 2021. http://hdl.handle.net/10393/41943.
Texte intégralWang, Yang. « Murine adriamycin-induced nephropathy : the roles of cell-mediated immunity and CD4+ T-lymphocytes ». Thesis, The University of Sydney, 2000. https://hdl.handle.net/2123/27827.
Texte intégralShao, Liang, et 邵亮. « Study on the role of CD4⁺CD25⁺ regulatory T cells in acute and chronicgraft-versus-host disease in murine models ». Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hub.hku.hk/bib/B50534014.
Texte intégralpublished_or_final_version
Medicine
Doctoral
Doctor of Philosophy
Khan, Muhammad Akram [Verfasser]. « Expansion of regulatory T cells in Theiler’s murine encephalomyelitis virusinfected C57BL/6 mice / Muhammad Akram Khan ». Hannover : Bibliothek der Tierärztlichen Hochschule Hannover, 2015. http://d-nb.info/1073883086/34.
Texte intégralHutchison, Sharon. « Investigation of the role of T cells in airway inflammation using novel murine models of disease ». Thesis, University of Glasgow, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.443198.
Texte intégralAbajyan, Anaida. « Characterization of altered cytokine production by memory CD4 T cells in NZBxW murine model of SLE ». Doctoral thesis, Humboldt-Universität zu Berlin, 2019. http://dx.doi.org/10.18452/20094.
Texte intégralSystemic lupus erythematosus (SLE) is an autoimmune disease, which can affect almost every organ system of the body. Thereby altered cytokine production by T cells plays an important role in the pathogenesis of the disease. With disease progression, production of IL-2 decreases and production of IFN-γ increases. It has been shown that IL-2 deficiency affects Treg homeostasis in SLE and thus contributes to its pathogenesis. The role of IFN-γ in SLE is, however, controversial. In this work, a comprehensive characterization of four subpopulations of memory CD4 T cells of diseased NZBxW lupus-prone mice was performed. These cell subsets are DN (IFN-γ—IL-2— double negative), IL-2 SP (IFN-γ—IL-2+ single positive), DP (IFN-γ+IL-2+ double positive) and IFN-γ SP (IFN-γ+IL-2—single positive) cells. A multi-step cell sorting procedure was used to isolate these cell subsets. The data showed that IFN-γ SP cells were characterized by a different gene expression profile than DP cells. In detail, IFN-γ SP cells revealed an enhanced expression of chemokine receptors, co-stimulatory and co-inhibitory molecules as well as apoptosis markers and decreased production of effector cytokines. In addition, functional analyses showed that IFN-γ SP cells were tended to increased apoptosis and decreased proliferation. These data show an altered phenotype of IFN-γ SP cells of diseased NZBxW lupus-prone mice, which might be important for the disease pathogenesis at least in this animal model of SLE.
Kaveri, Deepika. « Study of the role of Wnt pathway in a murine model of T-ALL ». Phd thesis, Université de Strasbourg, 2012. http://tel.archives-ouvertes.fr/tel-00912330.
Texte intégralAnanth, Abhirami. « Surgical Stress Attenuates Pre-existing Anti-tumour Immunity Resulting in Postoperative Metastases and local Recurrence in a Murine Model ». Thesis, Université d'Ottawa / University of Ottawa, 2014. http://hdl.handle.net/10393/31697.
Texte intégralKusuba, Nobuhiro. « Inhibition of IL-17-committed T cells in a murine psoriasis model by a vitamin D analogue ». Kyoto University, 2019. http://hdl.handle.net/2433/243300.
Texte intégralBerjanskii, Mark. « Structure and dynamics of the N-terminal J-domain of T antigens of murine polyomavirus ». MU online access free, to others for fee Free online access, 2002. http://wwwlib.umi.com/cr/mo/preview?3052146.
Texte intégralPfeilschifter, Janina Marie. « Targeting B non-Hodgkin lymphoma and tumor-supportive follicular helper T cells with anti-CXCR5 CAR T cells ». Doctoral thesis, Humboldt-Universität zu Berlin, 2021. http://dx.doi.org/10.18452/23169.
Texte intégralCAR T cell therapy is a promising new treatment option for patients suffering from aggressive B non-Hodgkin lymphomas (NHLs). In CAR T cell therapy, patient-derived T cells are genetically modified to express a chimeric receptor commonly directed towards a surface antigen expressed by neoplastic cells. In this thesis, anti-CXCR5 CAR T cell therapy was investigated as an alternative to anti-CD19 CAR T cell therapy for the treatment of mature B-NHLs. CXCR5 is a B cell homing receptor expressed by mature B cells and follicular helper T (TFH) cells. TFH cells were described to support the tumor cells in chronic lymphocytic leukemia (CLL) and follicular lymphoma (FL). This expression pattern allows simultaneous targeting of the malignant cells and the tumor-supporting microenvironment by CAR T cell therapy against a chemokine receptor in an unprecedented manner. Main findings included that (1) anti-CXCR5 CAR T cells targeted specifically CXCR5 expressing mature B-NHL cell lines and patient samples in vitro and showed strong in vivo anti-tumor reactivity in an immunodeficient xenograft mouse model, (2) anti-CXCR5 CAR T cells targeted tumor-supportive TFH cells derived from CLL and FL patient samples in vitro and (3) CXCR5 showed a safe expression profile. CXCR5 was strongly and frequently expressed by B-NHLs and its expression on healthy tissue was restricted to lymphoid cells. In summary, anti-CXCR5 CAR T cell therapy presents a novel treatment option for patients suffering from mature B-NHLs by eliminating the tumor and part of the tumor-supportive microenvironment. The second part of the project, the Eμ-Tcl1 murine lymphoma model, which mimics human CLL, was used to study the impact of lymphomagenesis on CXCR5+ T cells. Using single cell RNA sequencing, a profound influence of lymphoma growth on the T cell compartment in Eμ-Tcl1 tumor-challenged mice could be shown.
Mays, Jacqueline Wiesehan. « Psychosocial stress modulation of the murine anti-viral immune response during a primary influenza infection and the impact on immunologic memory ». Columbus, Ohio : Ohio State University, 2009. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1241712390.
Texte intégralKim, Wooki. « Molecular mechanisms of immunosuppressive effects of dietary n-3 pufa, curcumin and limonin on murine cd4+ t cells ». [College Station, Tex. : Texas A&M University, 2008. http://hdl.handle.net/1969.1/ETD-TAMU-3212.
Texte intégralMora, Ahmed. « Expression and function of the chemokine receptor XCR1 on murine CD8 + DC ». Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2010. http://dx.doi.org/10.18452/16088.
Texte intégralThe G protein-coupled receptor XCR1 has been described as the sole receptor for the chemokine ATAC. As contradictory data were published on the expression pattern of XCR1, its role in the immune system has not yet been defined. In this work, expression of XCR1 was characterized in B6.XCR1 lacZ+/+ reporter mice which express β galactosidase under the control of the XCR1 promoter. In tissue sections, strong expression of XCR1 was only detected in lymphoid organs like spleen, lymph nodes and thymus. In the spleen, XCR1+ cells were mainly found in the marginal zones, but also in the red pulp and the T cell zones. Flow cytometric analysis demonstrated exclusive expression of XCR1 on DC, mainly on the CD8+ DC subset, but also on a minority of CD4− CD8− DC. In vivo, these XCR1+ cells migrated in response to chemotactic or inflammatory stimuli: application of either an ATAC-expressing cell line or LPS induced within 3 9 h the translocation of XCR1+ cells to the T cell area of the spleen. When tested for phagocytic capacity, XCR1+ CD8+ DC, but not other DC subsets, specifically took up injected allogeneic cells, and transfection of these cells with ATAC significantly enhanced their endocytosis by XCR1+ CD8+ DC. Thus, we could employ allogeneic cells expressing OVA intracellularly to target antigen selectively to XCR1+ DC. This antigen targeting induced a strong antigen-specific cytotoxic response by endogenous T cells without a generation of OVA-specific antibodies. In the absence of ATAC, the endogenous cytotoxic activity was markedly diminished. Adoptive transfer and activation of wild type or ATAC-deficient OVA-specific CD8+ transgenic T cells confirmed that ATAC is required for the generation of an optimal cytotoxic response. Targeting of antigen to CD8+ DC via XCR1 may thus be a promising strategy for the development of new vaccination approaches aimed at optimizing the induction of cytotoxic T cells.
Massey, Robert D. « Peptide expressing phage used as an immunological stimulant for the treatment of murine mammary tumors / ». abstract and full text PDF (UNR users only), 2000. http://0-gateway.proquest.com.innopac.library.unr.edu/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:9997143.
Texte intégralIreland, Demelza Jane. « Intra-tumoural regulatory T cells : a potential new target for anti-cancer immunotherapy ». University of Western Australia. School of Biomedical, Biomolecular and Chemical Sciences, 2007. http://theses.library.uwa.edu.au/adt-WU2007.0076.
Texte intégralSteer, Henry John. « Combining chemotherapy with immunotherapy to treat mesothelioma : an investigation into the role of CD4+ T cells in a murine model ». Thesis, University of Nottingham, 2013. http://eprints.nottingham.ac.uk/13672/.
Texte intégralOkumura, Kazuhiro. « Expression of a novel isoform of Vav, Vav-T, containing a single Srchomology 3 domain in murine testicular germ cells ». Kyoto University, 2000. http://hdl.handle.net/2433/180822.
Texte intégralJha, Vibha. « Cellular regulation of mercury-induced autoimmunity ». Diss., Temple University Libraries, 2009. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/60597.
Texte intégralPh.D.
Etiological agents causing autoimmune diseases largely remain unknown. However, several lines of evidence suggest that environmental factors such as heavy metals (arsenic, lead and mercury) play a crucial role in the development of autoimmune disorders. In our model of mercury-induced autoimmunity, administration of subtoxic doses of HgCl2 to genetically susceptible strains of mice result in an autoimmune disease characterized by the production of highly specific anti-nucleolar autoantibodies, hypergammaglobulinemia and nephritis. However, mice can be tolerized to the disease by a single low dose administration of HgCl2 (tolerogenic dose). Previous studies from our lab had demonstrated that CD4+ CD25+ Foxp3+ regulatory T cells (Tregs) control the induction and maintenance of tolerance to mercury. We investigated the therapeutic role of Tregs in our model by utilizing agents that are known to stimulate in vivo expansion of Tregs. We studied two such agents, CD3-specific non-Fc receptor-binding [(Fab’)2 fragment] monoclonal antibody (Anti-CD3) and immune complexes containing recombinant IL-2 and anti-IL-2 monoclonal antibody (IC). In our model, treatment of mice with Anti-CD3 had no effect on Treg population. Administration of Anti-CD3 with the tolerogenic dose prevented induction of tolerance and failed to improve the maintenance period of tolerance. Anti-CD3 in presence of mercury activated the immune-system causing splenomegaly and expansion of B cell population. Overall, in contrast to its protective role in other experimental autoimmune disease models, Anti-CD3 exacerbated mercury-induced autoimmune syndrome. Treatment of mice with IC resulted in selective expansion of Tregs with a modest decrease in IgE levels and autoantibody production. Administration of IC with the tolerogenic dose led to a reduction in autoantibody response, thus IC was able to extend the maintenance period of tolerance to mercury. Lymphocyte Activation Gene-3 (LAG-3) is an inhibitory molecule that maintains lymphocyte homeostatic balance by controlling effector T cell expansion and contributing to the suppressive functions of Tregs. Thus, with the goal to understand the impact of homeostatic balance on Hg-induced autoimmunity, we investigated the role of LAG-3 in our model. Administration of an anti-LAG-3 monoclonal antibody broke tolerance to Hg resulting in autoantibody production and an increase in levels of serum IgE. Additionally, LAG-3-deficient B6.SJL mice exhibited an increased susceptibility to mercury-induced autoimmunity whereas, wild type controls suffered only from a mild disease. Moreover, adoptive transfer of wild-type CD4+ T cells protected LAG-3-deficient mice from mercury-induced autoimmunity. Therefore, we conclude that LAG-3 exerts an important regulatory effect on autoimmunity elicited by a common environmental pollutant.
Temple University--Theses
Sanlaville, Amélien. « Rôle de la réponse immunitaire adaptative anti-tumorale dans l’induction de la transition épithélio-mésenchymateuse ». Thesis, Lyon, 2016. http://www.theses.fr/2016LYSE1276.
Texte intégralCurrent clinical challenge in many carcinomas is to reduce the risk of metastasis development and cancer recurrence. Epithelial-mesenchymal transition (EMT), a physiological process during embryogenesis, is a central mechanism in oncogenesis. EMT induction contributes to early transformation and dissemination through inhibition of cellular surveillance (apoptosis and senescence) and increased migrative and invasive behavior. Another necessary hallmark of cancer is the ability of tumor cells to evade immune surveillance, a powerful barrier against tumor progression. But cancer cells enjoy intricate relations with the immune system. Whereas inclination of inflammation and innate immune cells to favor tumor development and immune escape, via EMT induction and immunosuppressive microenvironment maintenance, has been well investigated, the role of adaptive immune response in EMT promotion is understudied. Based on the development of a plastic murine mammary tumor cell line model overexpressing Her2/Neu oncogene, this study demonstrate in vivo that tumor cells keep an epithelial phenotype in adaptive immunodeficient mice but undergo EMT under the pressure of T-cell mediated immune response, characterized by loss of epithelial EpCAM marker and acquisition of mesenchymal features and EMT transcriptomic signature. CD4 T cell depletion but not CD8 restores the epithelial phenotype of tumors, suggesting that CD4 T cells mediate an immune response that could lead ton EMT induction. In return, EMT confers the ability of tumor cells to shape immunity like intra-tumor neutrophil infiltration. This work shed a new light on interactions between tumor cells and immune system
Chen, S. K. « Induction and maintenance of tolerance generated by temporary blockade of CD4 and CD8 on peripheral T cells in murine allo- and xenografts ». Thesis, University of Cambridge, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.597534.
Texte intégralOyama, Atsushi. « Up-regulated TGF-β mRNA expression in splenic T cells of high IgA-prone mice : a murine model of IgA nephropathy with glomerulosclerosis ». Kyoto University, 2001. http://hdl.handle.net/2433/150601.
Texte intégralKaraki, Soumaya. « Effets immunorégulateurs de la protéine GILZ (Glucocorticoid-induced leucine Zipper) sur la fonction des cellules dendritiques dans la réponse immunitaire allergique : étude Clinique et expérimentale ». Phd thesis, Université Paris Sud - Paris XI, 2011. http://tel.archives-ouvertes.fr/tel-00923138.
Texte intégralKeller, Emma Jean. « The Contribution of IFNα-Stimulated Immune Cell Populations to B6.NbA2 Lupus-likeDisease ». Case Western Reserve University School of Graduate Studies / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=case1625138193480211.
Texte intégralAbajyan, Anaida [Verfasser], Andreas [Gutachter] Radbruch, Michal [Gutachter] Or-Guil et Falk [Gutachter] Hiepe. « Characterization of altered cytokine production by memory CD4 T cells in NZBxW murine model of SLE / Anaida Abajyan ; Gutachter : Andreas Radbruch, Michal Or-Guil, Falk Hiepe ». Berlin : Humboldt-Universität zu Berlin, 2019. http://d-nb.info/1189214032/34.
Texte intégral