Littérature scientifique sur le sujet « Multifactorial animal model »
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Articles de revues sur le sujet "Multifactorial animal model"
Pikman, R., S. Kivity, Y. Levy, M.-T. Arango, J. Chapman, H. Yonath, Y. Shoenfeld et S. G. Gofrit. « Neuropsychiatric SLE : from animal model to human ». Lupus 26, no 5 (avril 2017) : 470–77. http://dx.doi.org/10.1177/0961203317694261.
Texte intégralAndersson, Leif. « Fisher’s quantitative genetic model and the molecular genetics of multifactorial traits ». Journal of Animal Breeding and Genetics 135, no 6 (octobre 2018) : 391–92. http://dx.doi.org/10.1111/jbg.12362.
Texte intégralVon Diemen, Vinicius, Eduardo Neubarth Trindade et Manoel Roberto Maciel Trindade. « Experimental model to induce obesity in rats ». Acta Cirurgica Brasileira 21, no 6 (décembre 2006) : 425–29. http://dx.doi.org/10.1590/s0102-86502006000600013.
Texte intégralNakhleh-Francis, Yara, Yaseen Awad-Igbaria, Reem Sakas, Sarina Bang, Saher Abu-Ata, Eilam Palzur, Lior Lowenstein et Jacob Bornstein. « Exploring Localized Provoked Vulvodynia : Insights from Animal Model Research ». International Journal of Molecular Sciences 25, no 8 (11 avril 2024) : 4261. http://dx.doi.org/10.3390/ijms25084261.
Texte intégralOlexová, Lucia, Tomáš Senko, Peter Štefánik, Alžbeta Talarovičová et Lucia Kršková. « Habituation of exploratory behaviour in VPA rats : animal model of autism ». Interdisciplinary Toxicology 6, no 4 (1 décembre 2013) : 222–27. http://dx.doi.org/10.2478/intox-2013-0033.
Texte intégralNetto, Cesar de Cesar, Zijun Zhang, Mario Lobao Goncalves, Chris Cychosz, Shuyuan Li, Kyle R. Duchman, Jessica E. Goetz, John E. Femino, Ruth Chimenti et Lew C. Schon. « Mechanical Overload Followed by Consecutive Collagenase Injections : Developing a Multifactorial and Long-Lasting Animal Model of Induced Achilles Tendinopathy ». Foot & ; Ankle Orthopaedics 5, no 4 (1 octobre 2020) : 2473011420S0003. http://dx.doi.org/10.1177/2473011420s00034.
Texte intégralUreshino, Rodrigo Portes, Angelica Jardim Costa, Adolfo Garcia Erustes, Gustavo José da Silva Pereira, Rita Sinigaglia-Coimbra et Soraya Soubhi Smaili. « Effects of Aging in the Striatum and Substantia Nigra of a Parkinson’s Disease Animal Model ». Toxicologic Pathology 46, no 3 (avril 2018) : 348–58. http://dx.doi.org/10.1177/0192623318767065.
Texte intégralSauer, Sven W., Silvana Opp, Shoko Komatsuzaki, Anna-Eva Blank, Michel Mittelbronn, Peter Burgard, D. M. Koeller, Jürgen G. Okun et Stefan Kölker. « Multifactorial modulation of susceptibility to l-lysine in an animal model of glutaric aciduria type I ». Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1852, no 5 (mai 2015) : 768–77. http://dx.doi.org/10.1016/j.bbadis.2014.12.022.
Texte intégralPerše, Martina, et Anton Cerar. « Dextran Sodium Sulphate Colitis Mouse Model : Traps and Tricks ». Journal of Biomedicine and Biotechnology 2012 (2012) : 1–13. http://dx.doi.org/10.1155/2012/718617.
Texte intégralZerani, Massimo, Angela Polisca, Cristiano Boiti et Margherita Maranesi. « Current Knowledge on the Multifactorial Regulation of Corpora Lutea Lifespan : The Rabbit Model ». Animals 11, no 2 (25 janvier 2021) : 296. http://dx.doi.org/10.3390/ani11020296.
Texte intégralThèses sur le sujet "Multifactorial animal model"
Lahogue, Caroline. « Stratégie de traitement visant les récepteurs 5-HT6 dans un modèle animal de schizophrénie innovant ». Electronic Thesis or Diss., Normandie, 2023. http://www.theses.fr/2023NORMC433.
Texte intégralSchizophrenia (SCZ) is a multifactorial mental disease which has repercussions on patients' personal and professional lives. While at least 1/3 of patients with SCZ present a remission of symptoms, other patients display persistent or even an aggravation of symptoms over time. To improve current treatments by testing new therapeutic targets, animal models need to be improved to get closer to the etiology of SCZ. We have developed a new multifactorial model which combines in mouse a genetic factor (1st hit, deletion of the serine racemase gene) with an early environmental stress (2nd hit, maternal separation for 24h on postnatal day 9). Our behavioral study showed that the interaction between the two factors in 2-hit mice leads to productive-like symptoms and cognitive deficits, observed in SCZ. However, the ex-vivo electrophysiological study reveals no specific pathophysiology of the functional activity of the hippocampal CA1 field in this model. Then, we tested the efficacy of blockade of serotonin subtype 6 receptors (5-HT6R) with a selective antagonist, SB-271046. This blockade induces beneficial effects on cognitive deficits, particularly memory, by improving working memory and sociability deficits in 2-hit mice. Electrophysiological studies show that 5-HT6R antagonism facilitates glutamatergic neurotransmission by two distinct sex-dependent mechanisms: an indirect activation of pyramidal neurons in males via a blockade of GABAergic inhibition, and a direct activation of pyramidal neurons in females. In 2-hit mice, only the disinhibition mechanism of pyramidal neurons induced in males by 5-HT6R blockade is altered.This thesis shows the interest of developing multifactorial models to get closer to the complex etiology of SCZ. It also shows the potential of 5-HT6R to treat several SCZ-related deficits, which are currently untreated, and suggests that it could be a useful adjunct treatment to neuroleptics
Percelay, Solenn. « Validation d'un modèle murin de schizophrénie pour améliorer la recherche de nouveaux traitements : approche psychopharmacologique, en imagerie et en électrophysiologie A new 3-hit mouse model of schizophrenia built on genetic, early and late factors Functional dysregulations in CA1 hippocampal networks of a 3-hit mouse model of schizophrenia Olfactory laterality is valence-dependent in mice Assessing olfactory laterality in mice : new tool in preclinical psychiatric study Combination of MAP6 deficit, maternal separation and MK801 in female mice : a 3-hit animal model of neurodevelopmental disorder with cognitive deficits Antipsychotic lurasidone : Behavioural and pharmacokinetic data in C57BL/6 mice ». Thesis, Normandie, 2021. http://www.theses.fr/2021NORMC403.
Texte intégralAffecting 1% of worldwide population, schizophrenia is a debilitating pathology. Whether the aetiology of schizophrenia remains unknown, its multifactorial aspect is conversely now well admitted, and certainly gathers genetic vulnerability and environmental factors. Actual treatments are still unmet, particularly for negative and cognitive symptoms. For a better translation from treatments design of schizophrenia to clinical efficiency, there is a crucial need to refine preclinical animal models that considers the multifactorial aspects of this disease.We developed a new murine multifactorial model of schizophrenia (3-hit), that possesses a strong construct validity. To this, we combined a genetic predisposition (1st hit: partial deletion of MAP-6) with an early postnatal stress (2nd hit: 24 h maternal separation at postnatal day 9), and a late cannabinoid exposure during adolescence (3rd hit: tetrahydrocannabinol THC from post-natal day 32 to 52; 8 mg/kg/day).First, we characterised a promising face validity through behavioural, imaging and electrophysiological studies. At behavioural level, we demonstrated that 3-hit mice displayed negative-like symptoms, cognitive deficits and altered olfactory laterality. Moreover, we showed a sensory motor gating deficit, that is a major translational clue for animal models of schizophrenia. Additionally, 3-hit mice displayed some characteristic morphological and functional impairments of the disease: reduced hippocampal volume, altered callosal fibres, glutamatergic and GABAergic neurotransmission dysfunctions. We moreover highlighted some sexual dimorphisms.Second, we compared deficits of 3-hit mice to those of others models of schizophrenia developed in our laboratory. Deficits induced by one factor, or combination of several factors, evidenced a synergistic effect, and not a simple addition between each of them.The 3-hit model therefore presents strong construct validity and promising face validity, encouraging to assess the pharmacological validity
Jiao, Hong. « Genetic dissection of multifactorial disease models in the rat / ». Stockholm, 2002. http://diss.kib.ki.se/2002/91-7349-287-6.
Texte intégralLivres sur le sujet "Multifactorial animal model"
DRAGANI. Human Polygenic Diseases : Animal Models. Taylor & Francis, 1998.
Trouver le texte intégralChapitres de livres sur le sujet "Multifactorial animal model"
Karalis, Katia P. « Multifactorial regulation of the corticotroph axis : animal models ». Dans The Acth Axis : Pathogenesis, Diagnosis and Treatment, 47–64. Boston, MA : Springer US, 2003. http://dx.doi.org/10.1007/978-1-4615-0501-3_3.
Texte intégralBortolato, Marco, et Roberto Cadeddu. « Animal Models of Tic Disorders ». Dans Tourette Syndrome, sous la direction de Liana Fasching, Melanie Brady et Flora M. Vaccarino, 277–98. 2e éd. Oxford University Press, 2022. http://dx.doi.org/10.1093/med/9780197543214.003.0017.
Texte intégralRasche, Axel. « Approaching Type 2 Diabetes Mellitus by Systems Biology ». Dans Handbook of Research on Systems Biology Applications in Medicine, 361–76. IGI Global, 2009. http://dx.doi.org/10.4018/978-1-60566-076-9.ch022.
Texte intégralRho, Jonathan, Paul Percelay, Sophie Pilkinton, T. J. Hollingsworth, Ilyse Kornblau et Monica Jablonski. « An Overview of Age-Related Macular Degeneration : Clinical, Pre-Clinical Animal Models and Bidirectional Translation ». Dans Animal Models in Medicine and Biology [Working Title]. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.96601.
Texte intégral« The Biology of Cytokines : General Principles, Properties, and Lessons from Animal Models ». Dans Cytokine Gene Polymorphisms in Multifactorial Conditions, 31–62. CRC Press, 2006. http://dx.doi.org/10.1201/9781420005325-9.
Texte intégralAlonazi, Fahad N., Yousef M. Hawsaw, Helal G. Alanazi, Adel M. Alqarni, Suad A. Alghamdi et Rakan J. Alanazi. « Animal Models for Cancer ». Dans Animal Models In Experimental Medicine, 1–19. BENTHAM SCIENCE PUBLISHERS, 2024. http://dx.doi.org/10.2174/9789815196382124010004.
Texte intégralCachuba, Roberta Mello, Elaine Carlos Scherrer, Karla Antunes Ramos, Alessandra Paula Carli, Sandra Bertelli Ribeiro Castro et Caio César Souza Alves. « Multiple sclerosis and experimental autoimmune encephalomyelitis : A review ». Dans UNITING KNOWLEDGE INTEGRATED SCIENTIFIC RESEARCH FOR GLOBAL DEVELOPMENT. Seven Editora, 2023. http://dx.doi.org/10.56238/uniknowindevolp-045.
Texte intégralMacrì, Simone, Martina Proietti Onori, Veit Roessner et Giovanni Laviola. « Animal Models Recapitulating the Multifactorial Origin of Tourette Syndrome ». Dans International Review of Neurobiology, 211–37. Elsevier, 2013. http://dx.doi.org/10.1016/b978-0-12-411546-0.00008-1.
Texte intégralRubattu, Speranza, Bruna Gigante, Rosita Stanzione et Massimo Volpe. « Animal models of stroke : implications for genetic studies of human stroke ». Dans Stroke Genetics, 115–26. Oxford University PressOxford, 2003. http://dx.doi.org/10.1093/oso/9780198515869.003.0005.
Texte intégralJuriloff, Diana M. « Mapping Studies in Animal Models ». Dans Cleft Lip And Palate, 265–82. Oxford University PressNew York, NY, 2002. http://dx.doi.org/10.1093/oso/9780195139068.003.0022.
Texte intégralActes de conférences sur le sujet "Multifactorial animal model"
Miquel Bartual, Mijo. « Modificaciones del concepto de lo salvaje en el antropoceno. » Dans III Congreso Internacional de Investigación en Artes Visuales : : ANIAV 2017 : : GLOCAL. Valencia : Universitat Politècnica València, 2017. http://dx.doi.org/10.4995/aniav.2017.6345.
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