Littérature scientifique sur le sujet « Movemement »

The paper presents a new procedure for bronze surface hardened by using intensive heating with laser beams (over 103 °C/s) which superficially melts the material. Afterwards the whole mass of the piece is subjected to blast cooling. For the used experimental conditions it was obtained a fine quenching microstructure with high harnesses, till 350 HV 0.5. The resulted structure has extremely fine grains which give an excellent resistance to cavitation erosions, because the dislocations movemement was heavily suppressed. Secondary, the residual compression tensions existing in the superficial layer delay the initiation of the cracks. Tertiary, the effects of bubble implosions are attenuated as a result of the holes realized on the surface by the laser beams treatment. Finally, the power of the laser beams upon the increase of the cavitation resistance was put into evidence.

Nomadism in postmodern stands as a principle of diffusion, allocation of bodies on social plane, implying a disruption with any fixedness: with Homeland, Home, family, identity. This principle is based on the constant movement, changes of the body. The following strategy forms a special chronotopy: space is constructed rhysomically (astructurally, acentered with equality of all possible directions of movement), and time is read a a cyclic present or as deplyment of past-future (Chronos and Eon in the concept of G. Deleuze). With transition to postmodern not only a man became a carrier of nomadic features, but also the bodies of an objective world became nomadic. Miniaturization of objects , which is accompanied by their intellectual filling, allows them to not only dive in an act of movement, but also incite movememnt and form space for realization of their own movement. A car, which in modern performed the function of subjugation of space with speed, in postmodern changed its functionality to comfort, and seriously influenced the formation of the map of the city. In this article a phenomenon of autonomadism is explored (embodiment of nomadism as a social strategy of mobility) through automobilization of society. Theoretical basis of the study is nomadological project of Deleuze – Guattari and concept of paradygm of mobility J. Urry. Among indicators which allow to talk about autonomadism are chronotopical metamorphosis in the reading of ambient landscape of motorists and the loss of identity, which led to the occurence of a hybrid “driver – car”. The following study showed that in postmodern Russian cities – metropolis a quiescence is seen as deviation and is socially excluded, spaces of quiet ar colonized by cars, sedentary places are exiled from the city or demand high economical expenses, which makes the settled way of life unprofitable.

This paper presents the results of a marine geophysical/geotechnical survey, which was carried out between Kerkyra and Paxi slope (part of the western Greek slope). The main bathymorphological features are numerous canyons and intercanyon ridges that exhibit high slope gradients (up to 30Ί). The canyon flanks as well as the ridges are affected by numerous mass movements that include slides, rotated sediment blocks, well-expresed sediment detachment surfaces, mass flows and creeping. Most of the aforementioned movememtns present a retrogressive action of the failure mechanism. The unstable sediment masses are often transported through the canyons and are deposited in the adjacent basin creating a sequence of alternating mass flow deposits and turbiditic/hemipelagic sediments. The gravity cores collected along two ridges, in the Kerkyra and Paxi slopes, revealed a certain sedimentary sequence consisting of calcareous ooze, oxidized mud and a sapropel layer overlaying hemipelagic mud. Along those sediment facies turbiditic muddy to sandy deposits usually appear. The main geotechnical characteristics of these lithofacies are the low undrained shear strength and high water content in the sapropel layer and the inverse relationship of the abovementioned properties in the oxidized mud. The water content of all the sediments is higher than the liquid limit indicating the very soft nature of the deposits and the possible destabilization upon disturbance (i.e. earthquake). The stability of the sedimentary cover was evaluated using the infinite slope, the Bishop and the Janbu methods. The main results that stemmed from the analysis are that (i) the Kerkyra slope is unstable both in static and dynamic conditions and (ii) the Paxi slope is unstable in dynamic conditions, whilst the very surficial layers (<1.5m in thickness) can be also unstable under static conditions. The possible failure planes are located 5-20m under the seabed. The absence of the oxidized mud and sapropel layers in the Kerkyra slope as well as their presence in the Paxi slope, and the presence of an episapropelic layer in the Kerkira-Paxi basin are all indicative of the unstable nature of the seafloor. Cyclic loading by earthquakes, high slope gradients and sediment bedding parallel to the slope are believed to be the predominant slope failure mechanisms in the surveyed area.

Parkinson’s disease, a degenerative brain disease of dopamine secreting brain cells Substantia nigra is increasing progressively and presents therapeutics -levodopa, carbidopa, MAOB inhibitor, COMT inhibitors, surgery and deep brain stimulations, though improve presenting feature but not quality of life. Present study using herbal composite containing Mucuna pruriens, Herpestis monnieri,Acors calamus, Nardostachys jatamansi and Withania somnifera taken in equal partshows better quality of life in all most all with marked improvement in movemement disorder in 92% cases as compared to 39% cases on conventional therapy. In addition Herbal composite also improve the haematological, hepatic and Renal function by bioregulating body biomechanics and neural cell function, revitalizing neural cell damage in substantia nigra check distruction of dopamine and facilitate optimal level of Dopamine for normal brain function.

Il termine Next generation sequencing (NGS) si riferisce ad un gruppo di moderne tecnologie di sequenziamento di acidi nucleici che rende possibile l’analisi di un elevato numero di sequenze di DNA o RNA sia per scopi diagnostici che di ricerca. Rispetto al sequenziamento tradizionale secondo Sanger, l’NGS permette di analizzare allo stesso tempo molti geni responsabili di patologie umane o di individuare nuovi geni ancora ignoti. Nel primo caso, vengono utilizzati in diagnostica pannelli genici dedicati, con costi relativamente contenuti e notevole risparmio di tempo rispetto al sequenziamento tradizionale. I disturbi del movimento sono un gruppo eterogeneo di disordini neurologici che possono manifestarsi in tutte le età della vita con un’anormale produzione del movimento stesso. Esistono molti disturbi del movimento su base genetica, specialmente nella popolazione pediatrica e l’NGS sta contribuendo in maniera significativa ad ampliare le conoscenze relative a queste patologie. Presso l’Istituto Carlo Besta vengono seguiti molti pazienti affetti da disturbi del movimento, inclusa un’ampia percentuale di casi ad esordio pediatrico. Durante il mio Dottorato di Ricerca, abbiamo analizzato tramite NGS pazienti selezionati, famiglie o gruppi omogenei di pazienti con lo stesso disturbo del movimento (es. distonia, corea) sia a fini diagnostici sia come parte di collaborazioni scientifiche con istituti esteri, focalizzandoci in particolar modo sui pazienti pediatrici. Grazie a ciò, abbiamo individuato nuovi pazienti con mutazioni in geni di recente scoperta (ADCY5, PDE10A) ed ampliato lo spettro fenotipico di geni già noti (GNAL, PSEN1). Inoltre, abbiamo partecipato a progetti di ricerca internazionali che hanno portato alla scoperta di nuovi geni responsabili di disturbi del movimento (KCTD17, PDE10A) con esordio prevalentemente pediatrico. Nonostante permangano alcuni limiti tecnici che necessitano di qualche cautela, l’utilizzo dell’NGS sta profondamente cambiando il modo in cui i clinici impostano l’iter diagnostico nei disturbi del movimento e sta contribuendo a ridurre progressivamente la percentuale di pazienti affetti da malattie rare ancora non caratterizzate geneticamente.
Next generation sequencing (NGS) refers to a group of innovative sequencing techniques that allow analyzing a high number of DNA or RNA sequences both for diagnostic and research purposes. As compared to traditional Sanger sequencing, NGS allows analyzing at the same time a large number of genes causally linked to human pathology or to search for new genes. In the first case, customized gene panels are used, with relatively low costs and substantial advantages in terms of time. Movement disorders are a heterogeneous group of neurological diseases that can manifest at any age with an abnormal movement production. There are several genetic causes of movement disorders, especially in the pediatric population, and NGS is contributing to significantly widen our knowledge of the genetic bases of several of these rare disorders. At Carlo Besta Neurological Institute, a large cohort of patients with rare movement disorders are followed, including a substantial proportion of pediatric cases. During my PhD course, we applied targeted resequencing and Whole Exome Sequencing to selected patients, kindreds or homogeneous subgroup of patients affected by specific movement disorders (e.g. chorea, dystonia) as part of routine diagnostic workup or in collaboration with foreign Institutes, with a particular focus on pediatric patients. We were able to identify carriers of recently discovered genes (ADCY5, PDE10A) and to widen the phenotypic spectrum previously associated with known genes (GNAL, PSEN1). Moreover, we contributed to international projects that allowed the discovery of new genes responsible for movement disorders (KCTD17, PDE10A) mainly with onset in childhood. Despite some technical limitations that still need some caution, the advent of NGS is profoundly changing the way clinicians diagnose movement disorders and is contributing to progressively decrease the proportion of patients with genetically undefined rare disease.

碩士
國立中央大學
中國文學系碩士在職專班
96
Affects in the Chinese modern times thought really great Mr. Liang Qichao, because the defect of Hundred Days’ Reform then goes into exile Japan. Under the coincidentally, the year of Guangxu 33 (in 1907) met unexpectedly with Mr. Lin Xiantang in Nara, the following closely the year Xuantong Period three years (in 1911), Mr. Liang Qichao visited to Taiwan invited by Mr. Lin Xiantang. These two meets, Mr. Liang Qichao instructed the Taiwan writers by the temperate practical way to resist Japanese people, strives for Taiwanese''s political status, this do really be the important key of Taiwan national movement in the future regarding the Taiwan knowledge outstanding person. Mr. Liang Qichao visited the Taiwan except to observe the Japanese residency general to govern the achievement in Taiwan, raise funds publishes a newspaper, but also participate in the prose reciting the activity, the family country mood which in the poem presents, the profound description is attached to sentiment of personally the motherland, also consoles the Taiwan people sorrowfully to lose the people gloomy mood. Mr. Liang Qichao’s Taiwan visit articles except really to present the Japanese people in the Taiwan colonial rule situation, and dares to give the criticism; Also drove the Taiwan people: poetry except recites the motherland mood, but also may express the current politics reflection reality straight. The Taiwan gentleman person to shoulder the maintenance traditional culture great task, the tenable poetry society extension Sinology, yet the Japanese faced the challenge of desire to cut off the connection of Taiwan and China thought. Failure of the Sino-Japanese War of 1894-1895, Taiwan is compelled accepts the political power shift the time drastic change, accrued the “motherland ── China” and “motherland ── Japan” the contradictory identification, urges the Taiwanese to strengthen the self-sympathy to condense into “Taiwan to realize”. After Mr. Liang Qichao left Taiwan, still with Mr Lin Xiantang continued the correspondence, demonstrated it Taiwan the value and the concern, held extremely strength of the image influence to the Taiwan knowledge individual contribution heart in then.