Bibliographies thématiques / Mouth diseases – drug therapy

Littérature scientifique sur le sujet « Mouth diseases – drug therapy »

Auteur : Grafiati

Publié le 26 juillet 2024

Mis à jour le 27 juillet 2024

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Articles de revues sur le sujet "Mouth diseases – drug therapy"

Kolesova, V. V., A. M. Lunegov, I. V. Lunegova, V. A. Baryshev et V. M. Matveev. « Comparative pharmacorrection of diseases of the mouth in cats ». Legal regulation in veterinary medicine, n^o 4 (8 janvier 2023) : 112–14. http://dx.doi.org/10.52419/issn2782-6252.2022.4.112.

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The article presents the results of comparative therapy of cats with inflammatory processes in the oral cavity (stomatitis, nigivit). We selected 30 cats, took the material for BAC-inoculation with subtitration to antibiotics, and analyzed the results. To compare therapy, which includes the use of an antibacterial drug and complex therapy, which includes additional processing of the oral cavity, two groups of animals were created. Based on previously obtained and known data, the first group of animals was prescribed doxycycline in oral form at a dose of 5 mg per kg 2 times a day for 7 days, the second group, the animals were prescribed doxycycline at the same dose, but additionally with the treatment of the oral cavity an aqueous solution of propolis and chlorhexidine bigluconate 0.12% 3 times a day after meals for 7 days. According to the results of BAC-inoculation with subtitration to antibiotics, it was revealed that the largest group of the studied animals was contaminated with Pasteurella multocida. All isolated microorganisms were sensitive to the prescribed antibiotic. After the therapy, it was noted that the state of the oral cavity in animals taking doxycycline and conducting local treatments with an aqueous solution of propolis, chlorhexidine bigluconate 0.12% was better than in animals with only the use of doxycycline. Improvements in the first group occurred by the end of the week of taking the drug, in the second - after an average of 3 days.

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Григорьев, С., S. Grigoryev, А. Козьменко et A. Kozmenko. « A new drug for xerostomia combination therapy ». Actual problems in dentistry 12, n^o 2 (26 juillet 2016) : 2–10. http://dx.doi.org/10.18481/2077-7566-2016-12-2-2-10.

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<p class="p1"><span class="s1">The article presents the effectiveness study results of the foam «Oral Care Foam 2 in 1» with the aim of moisturizing the mucous tunic of the mouth and preventing oral diseases for patients with xerostomia caused by medication taking. The clinical trial was conducted at the premises of the Dental Therapy Department of the Ural State Medical University. There was analyzed thedata on 60 patients having the signs of a dry mouth, having bacterial test provenoral moniliosis. On the basis of the study ndings one can conclude that usingthe foam «Oral Care Foam 2 in 1» regularly improves the quality of oral hygiene care, slows down the process of dental plaque formation and growth in patients with xerostomia caused by medication taking; causes no irritation and can be used for moisturizing purposes. </span></p>

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Abdollahi, Mohammad, Mania Radfar et Roja Rahimi. « Current Opinion on Drug-induced Oral Reactions : A Comprehensive Review ». Journal of Contemporary Dental Practice 9, n^o 3 (2008) : 1–15. http://dx.doi.org/10.5005/jcdp-9-3-1.

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Abstract Aim The aim of this comprehensive review is to present an update to our previous review about drug-induced oral reactions. All drugs that may cause adverse effects in the mouth and related structures are reviewed. Background Every drug can produce untoward consequences even when used according to standard or recommended methods of administration. Adverse drug reactions can involve every organ and system of the body and are frequently mistaken for signs of underlying disease. The mouth and associated structures can also be affected by many drugs or chemicals. Good oral health including salivary function is very important in maintaining whole body health. Drug reactions can be categorized as to the parts of the oral complex such as the oral mucosa and tongue, periodontal tissues, dental structures, salivary glands, cleft lip and palate, muscles, and nerves. Review Results This review suggests the number of drugs and chemicals that can produce adverse or toxic reactions in the oral cavity are on the rise. An updated listing of offending drugs is provided along with current strategies for dealing with adverse reactions. Conclusion Clinicians must constantly update their knowledge of drugs used by their patients. Attention must be paid to their toxic and unwanted effects that in many cases may be similar to characteristics of common diseases. Clinical Significance Dentists and specialists of oral diseases should be aware of adverse drug oral reactions for better diagnosis of oral diseases, administration of drugs, and patient compliance during drug therapy. Citation Abdollahi M, Rahimi R, Radfar M. Current Opinion on Drug-induced Oral Reactions: A Comprehensive Review. J Contemp Dent Pract 2008 March; (9)3:001-015.

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P R, Meenu, et Pradeep K. Kumar. « A REVIEW ON ASCHYOTANA THERAPY AND ITS YOGAS ». International Journal of Research in Ayurveda and Pharmacy 12, n^o 4 (28 août 2021) : 146–48. http://dx.doi.org/10.7897/2277-4343.1204124.

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Shalakya Tantra is one among the eight branches of Ayurveda which deals with Urdhwajatru Vikaras and their treatment. Urdhwajatru Vikaras include diseases of eye, ear, nose, mouth, and throat. Among them, Ophthalmology comprises major part of Shalakya Tantra. Kriyakalpas are the treatment modalities mentioned exclusively for eye diseases. It includes Aschyotana, Seka, Tarpana, Putapaka, Pindi, Vidalaka and Anjana. Aschyotana is considered as first line oftreatment in Netra Vikaras by Acharya Vagbhata. In this present era due to pollution and changing lifestyles there are manifestation of eye disorders. Many of this disease can be managed in their early stage itself by doing Aschyotana. Also, many simple and effective Aschyotana Yogas are mentioned in our classics by different Acharyas. In this paper an effort is taken to compile the references regarding Aschyotana therapy along with its Yogas (formulations) mentioned in Brihattrayis.

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Aditya, Vangara, et Kharidhi Laxman Vandana. « Evaluation of Different Local Drug Delivery Systems in Treatment of Periodontitis : An Institutional Study ». Journal of Multidisciplinary Dental Research 9, n^o 2 (24 décembre 2023) : 67–73. http://dx.doi.org/10.38138/jmdr/v9i2.23.19.

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Periodontal disease can be treated in both non-surgical and surgical therapy. There could be a possible reason why non-surgical therapy causes failure due to bacteria virulent factors and also the depth of periodontal pocket is greater than the instrumentation available, drug concentration is low in GCF as well as in saliva. To overcome this problem a treatment protocol that would include short-term usage of systemic and or local antimicrobial agents is being tried as an adjunct to mechanical therapy in treatment of periodontal diseases. A total of 540 sites, from 72 patients in different quadrants of the mouth received these treatment modalities in assigned quadrants such as scaling and root planning using both hand and ultrasonic instruments under local anesthesia (if required), combination therapy and local drug delivery alone. Patients with periodontal diseased sites were divided into five groups, based on the local drug delivery system, as Group I: Elyzol (25% Metronidazole), Group II: Dentomycin (2% Minocycline hydrochloride), Group III: Metrogene (5% Metronidazole), Group IV: Periochip (2.5mg of Chlorhexidine gluconate) and Group V: Atridox (10% Doxycycline hyclate). In the present study, the bleeding index score showed better reduction, for all LDD systems. The results showed that SRP alone, and LDD alone had shown no significance in overall reduction of pocket depth where clinical parameters (Plaque Index, Gingival Bleeding Index and Gingival Index). Although the combined treatment of scaling and root planing plus the local drug therapy reported to have a significant benefit over SRP alone in the treatment of periodontal lesions. Keywords: Anti-Bacterial Agents, Metronidazole, Minocycline, Doxycycline, Chlorhexidine, Local Drug Delivery Systems, Humans, Periodontitis, Periodontal Pocket, Root Planing

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Demir, Mehmet Gökhan. « The Effect of Arthrocentesis Treatment for Maximum Mouth Opening and Pain in Temporomandibular Joint Diseases and the Effect of Splint, Drug, and Physical Therapy on This Treatment ». Medicina 59, n^o 10 (4 octobre 2023) : 1767. http://dx.doi.org/10.3390/medicina59101767.

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Background and Purpose: Temporomandibular disorders (TMD) are a heterogeneous group of musculoskeletal and neuromuscular diseases involving the temporomandibular joint complex and the surrounding muscle and osseous structure. TMD can be classified as intra-articular or extra-articular. The aim of this study was to evaluate the effect of arthrocentesis in terms of maximum mouth opening (MMO) and pain in patients with TMD of intra-articular origin. In addition to this treatment, the effects of factors such as splints, medication, and physical therapy on arthrocentesis were examined. Material and methods: This retrospectively designed study was conducted with 79 patients who had previously undergone arthrocentesis. These patients were divided into three groups according to the Research Diagnostic Criteria for temporomandibular disorder: disc displacement (DD) with locking (Group 1), DD without locking (Group 2), and degenerative joint diseases (Group 3) groups. The maximum mouth opening (MMO) and visual analog score (VAS) values of the groups were recorded before arthrocentesis (Baseline: T0), on the third day after arthrocentesis (T1), and at the sixth month (T2) after arthrocentesis. Information about whether the patients received concurrent medical treatment, splint treatment, and physical therapy was also recorded. These data were compared between groups. Results: It was observed that the VAS scores in all three groups decreased from T1 compared to T0 (p < 0.05). Likewise, the MMO value increased in all groups at T1 compared to T0. (p < 0.05). It was observed that splint treatment, pain killer and muscle relaxant treatment, and physical therapy made no additional contribution to arthrocentesis in terms of reducing pain or increasing MMO value (p > 0.05). Conclusions: Arthrocentesis was observed to be effective in terms of pain and function in TMJ patients in this study. It was observed that splint therapy, physical therapy, and medical therapy made no additional contribution to arthrocentesis in terms of MMO or pain.

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Vieri, Audrey Amber, Rosiliwati Wihardja et Tenny Setiani Dewi. « Clinical appearance of oral lesions in bronchial asthma patients using inhalation drug ». Padjadjaran Journal of Dentistry 32, n^o 3 (30 novembre 2020) : 207. http://dx.doi.org/10.24198/pjd.vol32no3.27472.

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Introduction: Inhalation therapy has become the first-line treatment for bronchial asthma patients. Studies have proved that not all of the inhaled drugs reach the target organ, but mostly are deposited in the mouth and cause local immunosuppressant and decrease saliva secretion. These conditions are closely linked to some adverse effects in the mouth. The purpose of this study was to describe the clinical appearance of oral lesion in bronchial asthma patients using inhalation drugs. Methods: This study was descriptive and conducted on 30 bronchial asthma patients that have been using inhalation drug for at least one year, free of other systemic diseases, not using denture and orthodontic appliances. Oral mucosa was examined, and any oral lesion was recorded. Results: The most number of oral lesions found in patients through clinical examinations were plaque (73.3%), followed by a fissure (36.7%), atrophy (30%), and the least oral lesions found were pigmentation (3.3%), bullae (3.3%), and petechiae (3.3%). The lesions found in patients using inhalation drugs in a range of up to 10 years were found more varyingly. Conclusion: Plaque, fissure, atrophy, pigmentation, bullae, and petechiae are oral lesions that are clinically found in bronchial asthma patients using inhalation drugs.

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Сериков, N. Serikov, Серикова, O. Serikova, Щербаченко et O. Shcherbachenko. « Use of Physiotherapy in the Treatment of Oral Muco-sa (brief message) ». Journal of New Medical Technologies 21, n^o 2 (13 août 2014) : 65–68. http://dx.doi.org/10.12737/5001.

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Lichen planus is one of the most common diseases of the oral mucosa, which is characterized by a chronic course, clinical polymorphism, resistant to treatment, the possibility of malignancy. For treatment of the red lichen planus, the modern medicines are used: neurotropic, corticosteroids, aminoquinolinic preparations, antibiotics, retinoids, drugs, vitamins that have impact on different stages of pathogenesis. However, the prescription of these drugs is often inefficient, and is associated with the development of complications and the development of resistance to the therapy. The phenomena of toxic and allergic reactions in the use of drugs are frequent. Improvement of non-drug methods of treatment of the red lichen planus in mucous membranes of the mouth is an urgent task. Combined methods of physiotherapy are one way of treatment. Combined physiotherapy is physiotherapy, based on simultaneously (coinfection) use of two or more physical factors on the same area of the body. These factors were selected with the aim of increasing their physical activity and therapeutic effectiveness. One of the variants of combined physical therapy of diseases of the oral mucosa is the use of a device for the treatment of dental diseases «Radadent», in which there are two types of physical factors: the extremely high frequency electromagnetic and ultraviolet radiation. In the clinic of the Department of stomatology the apparatus «Radadent» was used in the complex treatment of 12 patients with erosive and ulcerative forms of red lichen planus. The reduction or elimination of inflammatory processes of the mucous membrane and the regeneration of tissues trophism of the mouth, elimination of pain, cell regeneration, the acceleration of healing of ulcers and ero-sions were identified.

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Jayachandran, Abirami Lakshmy, Radhika Katragadda, Ravinder Thyagarajan, Leela Vajravelu, Suganthi Manikesi, Shanmugam Kaliappan et Balaji Jayachandran. « Oral Candidiasis among Cancer Patients Attending a Tertiary Care Hospital in Chennai, South India : An Evaluation of Clinicomycological Association and Antifungal Susceptibility Pattern ». Canadian Journal of Infectious Diseases and Medical Microbiology 2016 (2016) : 1–6. http://dx.doi.org/10.1155/2016/8758461.

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Oropharyngeal candidiasis is one of the common manifestations seen in cancer patients on cytotoxic therapy and invasion into deeper tissues can occur if not treated promptly. Emergence of antifungal drug resistance is of serious concern owing to the associated morbidity and mortality. The present study aims at evaluation of clinicomycological association and antifungal drug susceptibility among the 180 recruited patients with cancer on chemotherapy and/or radiotherapy with signs or symptoms suggestive of oral candidiasis. Speciation and antifungal susceptibility was done by Microbroth dilution method for fluconazole, Itraconazole, and Amphotericin B as per standard microbiological techniques. Chi-square test was used for statistical analysis (p<0.05was considered statistically significant).Candida albicanswas the predominant species isolated (94) (58%) followed byCandida tropicalis(34) (20.9%). Fluconazole and Itraconazole showed an overall resistance rate of 14% and 14.8%, respectively. All the isolates were susceptible to Amphotericin B. There was a significant association between the presence of dry mouth and isolation ofCandida(p<0.001). Such clinicomicrobiological associations can help in associating certain symptoms with the isolation ofCandida. Species level identification with in vitro antifungal susceptibility pattern is essential to choose the appropriate drug and to predict the outcome of therapy.

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Aouroud, Hala, Adil Ait Errami, Nayala Hanane Essaidi, FZ Lairani, O. Nacir, Sofia Oubaha, Zouhour Samlani et Khadija Krati. « Compliance to Drug Therapy in Inflammatory Bowel Diseases : A Monocentric Experience ». International Journal of Innovative Research in Medical Science 8, n^o 10 (13 octobre 2023) : 464–68. http://dx.doi.org/10.23958/ijirms/vol08-i10/1763.

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Poor therapeutic compliance in inflammatory bowel diseases (IBD) has a negative impact on treatment efficacy and patients' quality of life. Addressing this issue requires an understanding of the factors involved, which include patient-related factors, socioeconomic conditions, treatment, and healthcare system factors. The aim of this study was to identify the factors responsible for poor therapeutic compliance in patients with IBD in our context. We conducted a prospective study involving 120 patients with IBD over a 10-month period. Data was collected using two questionnaires: one general questionnaire exploring factors influencing compliance and another specific one (Morisky Score) assessing the level of compliance. Of the 120 patients included, the average age was 39.66 years, with a female predominance. Crohn's disease was the most common pathology (71.7%), and 75% of patients were adherent to treatment. Lack of means was the most common reason for treatment abandonment. Bivariate analysis revealed a significant correlation between compliance, gender, monthly income, number of hospitalizations, number of daily doses, cost, perception of treatment importance, access to the treating physician, and mode of communication. Therefore, improving therapeutic compliance requires continuous support from healthcare professionals and the healthcare system, as well as responsible patients.

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Thèses sur le sujet "Mouth diseases – drug therapy"

Tavari, Mohsen. « Hybrid molecules as inhibitors of the monoamine oxidases and caspase 3 for neurodegenerative disorders ». University of the Western Cape, 2016. http://hdl.handle.net/11394/5069.

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Magister Pharmaceuticae - MPharm
Neurodegenerative diseases are multifactorial in nature, and taking the complex nature of these disorders into consideration, multi-target directed ligands may present as better options to treat these disorders than the classic ‘one molecule, one target’ approach. Neurotransmitter amines are catabolized by monoamine oxidase A and B (MAO-A and MAO-B), therefore they have been targeted for the treatment of neuropsychiatric and neurodegenerative diseases. Besides offering a potential antidepressant action in PD, MAO-A inhibitors may also provide a symptomatic benefit by reducing MAO-A-catalysed oxidation of dopamine. The oxidative deamination reaction catalyzed by MAO-B is one of the major catabolic pathways of dopamine in the brain. Inhibition of this enzyme leads to enhanced dopaminergic neurotransmission and are currently used in the symptomatic treatment of PD. Furthermore, MAO-B inhibitors may also exert neuroprotective effects by reducing the concentration of potentially hazardous by-products produced by MAO-B-catalysed dopamine oxidation. Apoptosis or programmed cell death occurs in a number of neurodegenerative disorders and it has been proven that inhibition of the executing enzyme, caspases-3, slows down or even stops apoptosis. Having this in mind we focused on the propargylamine function of selegiline and the fluorophenyl function of safinamide, because of their inherent monoamine oxidase inhibitory activities; and isatin as a non-peptide inhibitor of caspase-3. Therefore we attempted to design and synthesize multifunctional hybrid molecules acting simultaneously to halt the apoptotic neuronal breakdown process and eliminate the signs and symptoms of diseases such as PD. Seven novel compounds were successfully synthesized utilizing multistep processes. The synthesis of 5 chlorosulfonyl isatin was accomplished starting from the commercially available isatin in two steps, which were, sulfonation using tetramethylene sulfone and chlorination with POCl₃. Next 5-chlorosulfonyl isatin was conjugated to the fluorophenylamine derivative with the fluoro-function at either the ortho, meta or para position through a nucleophilic substitution reaction on the chlorosulfonyl position. The resultant compounds were coupled on the N position of the isatin function with propargyl bromide, using a microwave synthesis procedure, in a nucleophilic substitution reaction. The structures and purity were confirmed by nuclear magnetic resonance (NMR) and mass spectrometry (MS). In the biological evaluations recombinant human MAO-A, MAO-B and caspase 3 enzymatic assays were performed to determine the activity of the novel compounds at an enzymatic level. The inhibition percentages for these compounds were calculated and plotted against the logarithm 8 of the inhibitor concentrations to obtain a sigmoidal dose-response curve and consequently the IC50 value. The synthesized compounds showed inhibition of the MAO-A, MAO-B and caspase-3 enzymes at low to high micro molar concentrations. The role of the fluorophenylamine moiety in the synthesized compounds was significant for their multifunctional activity as shown by compounds 3 and 4 having good inhibitory activity towards MAO-A, MAO-B and also excellent inhibitory activity against caspase 3, making those ideal candidates for further lead compound development and multifunctional drug design. The introduction of the propargylamine moiety only increased the MAO-A inhibitory activity; this was shown by compounds 7, 8 and 9 which exhibit good MAO-A selectivity with low MAO-B and caspase-3 inhibitory activities.

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Zent, Clive Steven, et Clive Steven Zent. « The use of aminoglycoside antibiotic therapy in neutropaenic patients with haematological disease ». Master's thesis, University of Cape Town, 1991. http://hdl.handle.net/11427/24969.

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The use of aminoglycosides in the treatment of the febrile neutropaenic patient with haematological disease is difficult and often suboptimal. This study reviews the available literature to establish therapeutic guidelines in this population and then reports the use of a Bayesian statistics based predictive model to implement and manage therapy in 10 patients. A review of the literature on aminoglycoside Pharmacology and clinical use is essential to determine therapeutic guidelines for this population. Aminoglycosides are amino sugars in glycosidic linkage and are polycations at physiological PH. The antibiotic effect is mediated through inhibition of protein synthesis and disruption of cell membrane integrity. Principal use is in treatment of Gram negative infection although aminoglycosides have activity against some Gram positive organisms including staphylococci. Aminoglycosides are inactive against anaerobes. Acquired resistance is mediated by bacterial enzymatic drug metabolism. Aminoglycosides are nephro- and ototoxic, this is the major constraint in clinical use.

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Thomson, William Murray. « Medications, dry mouth and dental caries among older people : a longitudinal study / ». Title page, contents and abstract only, 1999. http://web4.library.adelaide.edu.au/theses/09PH/09pht4858.pdf.

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Yu, Zhen. « Altered drug responses in diabetic and hypertensive-diabetic cardiomyopathy ». Thesis, University of British Columbia, 1990. http://hdl.handle.net/2429/29406.

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Diabetes mellitus has been associated with both clinical and experimental cardiac dysfunction. Diabetic cardiomyopathy which is characterized by depressed cardiac contractility is accompanied by a variety of biochemical changes in Ca⁺⁺ metabolism. This cardiomyopathy may occur in the presence of normal coronary arteries and normal blood pressure. However, some studies have shown that hypertension is more prevalent among diabetics and can aggravate the cardiovascular abnormalities associated with diabetes. To understand the mechanisms of diabetic cardiomyopathy and consequences of combined hypertension and diabetes, experiments were designed to measure cardiac tissue responses to various inotropic agents in experimental diabetes. Six weeks following streptozotocin (STZ) administration, Wistar, spontaneously hypertensive (SHR) and Wistar Kyoto (WKY) rats exhibited the 'classical signs' of diabetes which included: hyperglycemia, hypoinsulinemia, hyperlipidemia (except in WKY), and hypothyroidism. Decreased basal atrial rate and increased basal developed force (BDF) suggest a depressed SA node function and an alteration of Ca⁺⁺ utilization by diabetic ventricles. Decreased post quiescent potentiation (PQP) values (except in WKY) in ventricular tissues suggest a diminished amount of releasable Ca⁺⁺ from sarcoplasmic reticulum (SR). Decreased post stimulation potentiation (PSP) values in SHR papillary muscles (PM) are probably suggestive of a depressed sarcolemmal Na⁺-Ca⁺⁺ exchange function in this tissue. Diabetic rats show subsensitivity to β-adrenergic stimulation in ventricular tissues, supersensitivity and hyperresponsiveness to Ca⁺⁺ and α-adrenergic stimulation (except in WKY) in ventricular tissues and left atria (LA) and supersensitivity to BAY K 8644 in SHR LA and hyperresponsiveness to verapamil in ventricular strips. These alterations may be attributed to a change in receptor number and/or a post receptor alteration. Ryanodine decreased the PQP of Wistar and SHR PM and SHR LA in both controls and diabetics. It especially abolished PQP in SHR diabetic tissues, but had no effect on WKY tissues, which may suggest a difference in the SR function in these tissues. SR with impaired Ca⁺⁺ uptake may contribute to these phenomena in diabetic rats. Ryanodine also diminished (PQP + BDF) of SHR LA and (PQP/BDF) of Wistar and SHR PM, ˙but had no effects on control and other diabetic tissues. It appears that ryanodine has some influence on the Na⁺-Ca⁺⁺ exchange generated by sarcolemma (SL) of certain diabetic tissues. Further experiments are required to clarify this. SHR diabetic rats had greater changes in most of the measurements such as hyperlipidemia, depressed PQP and PSP values, and altered drug responses. This model exhibited very high mortality as compared to Wistar and WKY diabetic rats. As has been shown previously, the combination of hypertension and diabetes exerts a synergistic effect on the cardiac dysfunction in this model, and that altered lipid metabolism, SL and SR function are all involved in the development of cardiomyopathy. WKY diabetic rats, on the other hand, exhibited no significant changes in blood lipids, or in response to phenylephrine or to Ca⁺⁺ (LA) stimulation. Lack of change in these factors may explain the relatively normal cardiac function of this model as measured previously.
Pharmaceutical Sciences, Faculty of
Graduate

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Flood, Lars. « Glucocorticosteroid therapy and steroid resistance in inflammatory bowel disease / ». Stockholm, 2004. http://diss.kib.ki.se/2004/91-7140-020-6/.

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Kucukturhan, Aysu. « Bioactive Agent Carrying Plga Nanoparticles In Thetreatment Of Skin Diseases ». Master's thesis, METU, 2012. http://etd.lib.metu.edu.tr/upload/12614551/index.pdf.

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The aim of this study was to develop drug delivery system based on poly(lactic acid-co-glycolic acid) (PLGA) nanoparticles (NPs) to achieve personalized treatment of selected skin disorders, like photo-aging, psoriasis and atopic dermatitis. Dead Sea Water (DSW) and Retinyl Palmitate (RP) were used as active agents and they were loaded in PLGA NPs prepared either as spheres or capsules by o/w or w/o/w methods. MgCl2 and bovine serum albumin (BSA) served as model active compounds. The diameter of the NPs was found to be in the range of 280 - 550 nm. The entrapment efficiency (E.E.) was less than 1% for RP, DSW and MgCl2, and 41% for BSA. Loading of Cl- together with BSA doubled the E.E. value of Cl- . In situ release studies showed a burst in the first day and more than 85% of the chloride content was released within a week. When the macromolecule BSA was encapsulated, a much slower and triphasic release profile was observed which continued for up to 80 days. In vitro tests were performed using L929 fibroblast cells. Results of MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) test revealed that none of the NPs were cytotoxic. Additionally, all particles were hemocompatible with hemolytic activity <
1.5%. L929 fibroblast and Saos 2 human osteosarcoma cells were used to study the uptake of NPs by the cells. Particles accumulate near the nucleus. The characterization and cell viability tests, and drug release behavior indicate the suitability of these NPs for further testing to develop a patient specific skin diseases treatment approach.

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Törneke, Karolina. « Pharmacological aspects of adrenoceptor drugs in the horse / ». Uppsala : Swedish Univ. of Agricultural Sciences (Sveriges lantbruksuniv.), 1999. http://epsilon.slu.se/avh/1999/91-576-5431-X.pdf.

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Cameli, Paolo. « The impact of antifibrotic therapy in the management of idiopathic pulmonary fibrosis and progressive fibrosing interstitial lung diseases : a real-world comparative study of efficacy between pirfenidone and nintedanib ». Doctoral thesis, Università di Siena, 2021. http://hdl.handle.net/11365/1159047.

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Background: Idiopathic pulmonary fibrosis (IPF) is the most common and lethal among diffuse fibrosing interstitial lung diseases (ILD). Beyond lung transplantion, the therapeutic approach relies on antifibrotic treatment: pirfenidone and nintedanib are the only pharmaceutical drugs approved for IPF, since they have demonstrated to significantly reduce disease progression rate. Still, no solid data has been published to compare these two drugs as well as few studies have investigated their potential efficacy on familial pulmonary fibrosis (FPF) and progressive fibrosing ILD (PF-ILD) in a real-life setting. Methods: we collected clinical, functional and radiological data from all patients affected with IPF and PF-ILDs that have been treated with pirfenidone and nintedanib at Referral Centre of Siena from 2011 to 2020. The aim of the research was to compare effectiveness of the two drugs in terms of mortality and disease progression in our population. Results: no significant differences in mortality and progression-free survival were observed between pirfenidone and nintedanib subgroup. Both drugs significantly reduce FVC and DLCO decline rate in respect with pretreatment period. Similar data was observed in the PF-ILD subgroup, while FPF patients showed no significant benefit from antifibrotic treatment in terms of disease progression. Pirfenidone was more effective than nintedanib in preserving FVC in FPF subgroup. Conclusions: our research study, conducted in a large cohort through a almost decennial time of observation, confirmed the reliable and substantially similar efficacy of pirfenidone and nintedanib in improving life expectancy and progression-free survival of IPF patients. FPF appeared to be less responsive to antifibrotics, but pirfenidone showed a better performance than nintedanib on this field. PF-ILD patients showed a analogue clinical course of IPF subjects in our study: the effectiveness of pirfenidone and nintedanib was reliable and similar, supporting their future use in clinical practice.

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Wang, Jianghai. « Human deoxyribonucleoside kinases : their substrate recognition and implications for chemotherapy / ». Uppsala : Swedish Univ. of Agricultural Sciences (Sveriges lantbruksuniv.), 1999. http://epsilon.slu.se/avh/1999/91-576-5427-1.pdf.

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Horn, Je'nine. « The analysis of 6- and 24-hour iodine-131 thyroid uptake in patients with Graves' disease at Universitas Hospital ». Thesis, [Bloemfontein?] : Central University of Technology, Free State, 2007. http://hdl.handle.net/11462/102.

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Thesis (M.Tech.)(Nuclear Medicine) -- Central University of Technology, free State, 2007
In the South African Health Services (SAHS) it is each health worker’s responsibility to find ways to reduce health care cost and improve health service to the public. The measurement of radioactive iodine uptake (RAIU) by the thyroid gland for diagnostic purposes has been used as early as the 1940s. The 24-hour (hr) iodine-131 (131I) uptake measurement is traditionally used for the calculation of the 131I administered activity for therapy dosage. This entails that the patient’s hospitalisation is prolonged, which increases the costs. The literature also indicates that the 24-hr 131I uptake value can be discarded and only the 6-hr 131I uptake measurement is needed to calculate administered activity for therapeutic dosages for Graves’ patients. Therefore, if it can be confirmed that the 6-hr 131I uptake measurement alone is needed, the SAHS could decrease hospitalisation costs. The overall goal of the investigation was to analyse the 6-hr and 24-hr 131I uptake measurements of patients with Graves’ disease at the Universitas Hospital. The aim was to determine the relationship between the 6-hr and 24- hr RAIU values to establish the therapeutic dosage for Graves’ disease. To achieve the aim, three objectives were set. First, to serve as a background to the investigation, a literature survey relating to the RAIU measurements of patients with Graves’ disease was made. Second, a retrospective analysis was performed by collecting the 6-hr and 24-hr 131I uptake measurements of patients with proven Graves’ disease at the Universitas Nuclear Medicine Department (UNMD). Finally, the data obtained from the retrospective analysis was analysed, summarised and compared to answer the investigation questions. The investigation group included patients with confirmed Graves’ disease who had undergone both the 6- and 24-hr 131I RAIU at the Universitas Hospital from the beginning of 2004 to the end of 2005. Graves’ disease is confirmed by the following factors at the UNMD, namely: Suppressed TSH, elevated T4 and T3 values, an increased uptake on the 99mTc-pertechnetate scan and increased 6- and 24-hr 131I RAIU values. The UNMD statistics show that 178 patients were diagnosed with Graves’ disease during this period. The patients of the investigation group included both male and female patients from different races, ranging from 15-75 years. In order to increase the validity of the investigation, all factors that could influence the accuracy of the 131I thyroid uptake test were excluded. After the exclusion and inclusion criteria had been applied, the final investigation group was made up of 124 Graves’ disease patients. The data obtained from the patient files was noted on the different data sheets (see Appendix A) for further analysis. The information from these data sheets was then used to obtain the investigation results. The Department of Biostatistics of the University of the Free State (UFS) was consulted for recommendations regarding the management of data and the processing of results. All values were summarised by means and Standard Deviations (SD) or percentiles. Mean or median differences were calculated with a 95% Confidence Interval (CI). A regression analysis was made between the 6-hr and 24-hr 131I RAIU values. The highest RAIU value is the best to calculate the therapeutic dosage, as this gives a true reflection of the thyroid function of a Graves’ disease patient. In the investigation group the median of the 24-hr 131I RAIU values was higher than the 6-hr 131I RAIU values. The findings showed that the 24-hr 131I RAIU in most of the investigation group was the highest value and most effective to calculate the 131I therapeutic dosage. At a time when research-based practice is taking on an increasingly important role, it is essential for nuclear medicine departments to make evidence-based recommendations. This investigation found that the correlation between the 6-hr and 24-hr RAIU clearly justified the cost spent on Graves’ disease patients who must stay overnight for the 24-hr 131I RAIU procedure.

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Robert, Newland J., dir. Oral soft tissue diseases : A reference manual for diagnosis & management. Hudson, Ohio : Lexi-Comp, 2001.

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Newland, J. Robert. Oral hard tissue diseases : A reference manual for radiographic diagnosis. 3^e éd. Hudson, Ohio : Lexi-Comp, 2012.

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Zambito, Raymond F. Immunology and infectious diseases of the mouth, head, and neck. St. Louis : Mosby Year Book, 1991.

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Seymour, R. A. Adverse drug reactions in dentistry. 2^e éd. Oxford : Oxford University Press, 1996.

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Seymour, R. A. Adverse drug reactions in dentistry. Oxford : Oxford University Press, 1988.

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H, Messerli Franz, dir. Cardiovascular drug therapy. 2^e éd. Philadelphia : Saunders, 1996.

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Khan, M. Gabriel. Cardiac drug therapy. 3^e éd. London : W.B. Sanders, 1992.

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J, Eadie Mervyn, dir. Drug therapy in neurology. Edinburgh : Churchill Livingstone, 1992.

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Corporation, Springhouse, dir. Cardiovascular drug therapy. Springhouse, Pa : Springhouse Corp., 1995.

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Khan, M. I. Gabriel. Manual of cardiac drug therapy. 2^e éd. London : Bailliere Tindall, 1988.

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Chapitres de livres sur le sujet "Mouth diseases – drug therapy"

Merk, Hans F., et Daniela Höller Obrigkeit. « Drug Reactions ». Dans Therapy of Skin Diseases, 297–319. Berlin, Heidelberg : Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-540-78814-0_29.

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Wehling, Martin. « Obstructive Lung Diseases ». Dans Drug Therapy for the Elderly, 135–42. Vienna : Springer Vienna, 2012. http://dx.doi.org/10.1007/978-3-7091-0912-0_11.

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Wu, Gencheng, Yanqing Wang et Xiaoding Cao. « Acupuncture-Drug Balanced Anesthesia ». Dans Acupuncture Therapy for Neurological Diseases, 143–61. Berlin, Heidelberg : Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-642-10857-0_6.

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Sepúlveda, Maria, Albert Saiz et Francesc Graus. « Targeting B Cells in Neurological Autoimmune Diseases ». Dans Milestones in Drug Therapy, 219–46. Basel : Springer Basel, 2013. http://dx.doi.org/10.1007/978-3-0348-0706-7_12.

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Bosch, Xavier, Pilar Brito-Zerón, Munther A. Khamashta et Manuel Ramos-Casals. « Targeting B Cells in Other Systemic Autoimmune Diseases ». Dans Milestones in Drug Therapy, 247–58. Basel : Springer Basel, 2013. http://dx.doi.org/10.1007/978-3-0348-0706-7_13.

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Laird, Glen. « Introduction to Rare Disease Therapy Development ». Dans Drug Development for Rare Diseases, 1–6. Boca Raton : Chapman and Hall/CRC, 2023. http://dx.doi.org/10.1201/9781003080954-1.

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Feng, Yi, et Boying Chen. « Effect of Acupuncture on Drug Addiction ». Dans Acupuncture Therapy for Neurological Diseases, 460–72. Berlin, Heidelberg : Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-642-10857-0_18.

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Chow, Shein-Chung. « Gene Therapy for Rare Diseases ». Dans Innovative Methods for Rare Disease Drug Development, 247–64. Boca Raton, FL : CRC Press, 2021. | : Chapman and Hall/CRC, 2020. http://dx.doi.org/10.1201/9781003049364-13.

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Winchester, James F. « Acute Drug Intoxications ». Dans Therapy of Renal Diseases and Related Disorders, 639–48. Boston, MA : Springer US, 1991. http://dx.doi.org/10.1007/978-1-4613-0689-4_40.

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Robinson, Peter. « Cell and Gene Therapy in Rare Diseases ». Dans Rare Disease Drug Development, 249–61. Cham : Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-78605-2_16.

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Actes de conférences sur le sujet "Mouth diseases – drug therapy"

Silveira, Rayanne Maria Brandão da, Marcela Marques de Oliveira Gregório, Elza Marcia Targar Yacubian et Laura Maria de Figueiredo Ferreira Guilhoto. « Cardiovascular risk in adults with drug-resistant epilepsy submitted to the modified atkins diet ». Dans XIV Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2023. http://dx.doi.org/10.5327/1516-3180.141s1.728.

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Introduction: The modified Atkins diet (MAD) the carbohydrates are limited to 15–30 g/d and high fat intake is encouraged. It are used in children, being less studied in adults Objectives: To assess the impact of MAD over a 6-month period in adults with drug-resistant epilepsy in terms of reduction in seizure frequency and cardiovascular risk. Methods: Prospective and interventional study.Inclusion criteria:patients aged 18–60 yrs, with drug-resistant focal epilepsy, without surgical indication or in the postoperative of epilepsy surgery. Exclusion criteria were: use of corticosteroids, metabolic diseases, cholecystectomy or nephrolithiasis, inadequate nutrition, uncooperative parents or caregivers and inadequate sociofamily dynamics. All started the diet at a 1:1 ratio and ASMs. Study periods: baseline (P0), six month (P6). Carotid and vertebral Doppler ultrasounds were performed at P0 and P6 in order to assess possible alterations related to of the carotid arteries the intima-media thickness. Results: Twenty patients are being followed up, 12 of which started the MAD, and of these, 6 completed the six-month period of diet therapy and underwent pre and post-diet exams. The 6 patients showed no increase in mean total, low-density lipoprotein, triglycerides cholesterol levels.There was no change in the thickness of the myointimal complex of any patient, made by comparative analysis by ultrasonographic exam before and after six months of starting the diet. Four out of 6 patients had >50% reduction in seizures (two seizure free) and two had no change in frequency. Conclusion: MAD for six months in adults with drug-resistant focal epilepsy had a significant effect on the reduction of epileptic seizures and did not reveal alterations in the myointimal wall of the carotid arteries.

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Thomas, E., et F. Blotman. « SP0064 Drug therapy in fibromyalgia. a review ». Dans Annual European Congress of Rheumatology, Annals of the rheumatic diseases ARD July 2001. BMJ Publishing Group Ltd and European League Against Rheumatism, 2001. http://dx.doi.org/10.1136/annrheumdis-2001.20.

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ХИЗРИЕВ, М. Д., И. Э. АТАШЕВА et З. О. ГАРУНОВ. « Drug therapy of patients with stable angina pectoris ». Dans II Международная научно-практическая конференция "Преобразование современного мира : проблемы и возможности". Crossref, 2024. http://dx.doi.org/10.26118/5186.2024.80.69.007.

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Одной из значимых проблем, которые продолжают убивать людей в мировой медицинской практике, являются заболевания системы кровообращения, несмотря на постоянное совершенствование методов лечения. В 2016 году сердечно-сосудистыми заболеваниями страдали, согласно отчету Всемирной организации здравоохранения, 17,9 млн человек, и это составило 85% всех случаев, связанных с инфарктами и инсультами, закончившимися летально [1]. По данным за 2020 год, в Российской Федерации 938 536 смертей вызваны болезнями системы кровообращения, из них 54,2% приходится на ишемическую болезнь сердца. Основными факторами, способствующими повышению потребности миокарда в кислороде, являются: тахикардия; повышенная сократимость; увеличенный объем, измеренный до и после левого желудочка или гипертрофии сердечной мышцы. В данной статье оценивается эффективность медикаментозной терапии, которая была рекомендована пациентам в качестве самостоятельного приема. На основании данных историй болезни 24 пациентов, было установлено, что частота употребления ЛС снизилась на 25%. One of the significant problems that continue to kill people in the world medical practice is diseases of the circulatory system, despite the constant improvement of treatment methods. In 2016, 17.9 million people suffered from cardiovascular diseases, according to a report by the World Health Organization, and this accounted for 85% of all cases associated with fatal heart attacks and strokes[1]. According to data for 2020, 938,536 deaths in the Russian Federation are caused by diseases of the circulatory system, of which 54.2% are due to coronary heart disease. The main factors contributing to increased myocardial oxygen demand are: tachycardia; increased contractility; increased volume measured before and after the left ventricle or hypertrophy of the heart muscle. This article evaluates the effectiveness of drug therapy, which was recommended to patients as an independent treatment. Based on the case histories of 24 patients, it was found that the frequency of drug use decreased by 25%.

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Borges, Érico Induzzi, André Lopez Fernandez, Louis Fernando Marques de Almeida, Juline do Prado Paes, Jandey da Glória Bigonha, Antônio José da Rocha, Herval Soares Ribeiro Neto et Sônia Maria Cesar de Azevedo Silva. « Progressive Multifocal Leukoencephalopathy following Daratumumab therapy for refractory Multiple Myeloma – a case report ». Dans XIII Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1516-3180.441.

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Context: PML is a dymyeliniating disease of the brain, caused by JC virus infection reactivation in immunocompromised patients, especially by AIDS, hematological disease and immunosuppressive therapies. Case report: A 67-year-old woman was diagnosed with multiple myeloma (MM) in 2018 and use of bortezomib/cyclophosphamide/dexamethasone and thalidomide was ineffective. She underwent treatment with monthly daratumumab starting in January 2020. After one year, she experienced progressive amnesia, apathy and confusion. At admission, examination revealed apathy, monosyllabic communication and frontal release, progressing to mutism and abulia. T2 FLAIR-weighted MRI of the brain performed in March 2021 showed a hyperintense non-enhancing lesion affecting thalamus, internal capsule, lentiform and deep white matter of left lobes. MRI performed one month before symptoms onset showed a small lesion in subinsular region – indicating incipient involvement. Cerebrospinal fluid PCR was positive for JC viruses, and PML was diagnosed. Conclusions: This report proves that concomitant hematologic and drug- immunocompromised patients presenting with neurological symptoms should be investigated for PML. There are few reports in the literature of PML occurring in MM, especially after use of daratumumab, an anti-CD38 monoclonal antibody. Recently, one small case series demonstrated some improvement in pembrolizumab (a checkpoint inhibitor)-treated PML, but no routinely therapy is recommended. Understanding severity of both disease, patient was discharged receiving conservative treatment.

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Cheung, S., F. Kudaeva, P. Heidari et D. Truong. « AB1665-PARE DRUG PERSISTENCE WITH THERAPY OF ADALIMUMAB BIOSIMILAR, MSB11022, IN RHEUMATOLOGIC DISEASES ». Dans EULAR 2024 European Congress of Rheumatology, 12-15 June. Vienna, Austria. BMJ Publishing Group Ltd and European League Against Rheumatism, 2024. http://dx.doi.org/10.1136/annrheumdis-2024-eular.5499.

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Barzizza, F., G. Belloni, E. Trespi, A. Venturini et I. Richichi. « HYPOGLYCEMIC EFFECT OF INDOBUFEN,AN ANTIAGGREGATING AGENT,IN ELDERLY DIABETIC PATIENTS ». Dans XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643100.

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Inibition of platelet aggregation is of value in therapy for Transient Ischemic Attacks(TIA).We observed 2 consecutive elderly patients with type 2 diabetes mellitus(DM)and TIA,in whom chronic treatment with Indobufen(I) provoked a reduction of blood glucose levels; for this reason we started a cross-over study to assess the possible hypoglycemic effect of I in elderly patients with DM.Ten patients(5 males,mean age 75±5 years)with DM and TIA have been included in our study. After 1 month of diet treatment(1)all patients took either placebo tablets 2)or I 200mg every 12 hours for 4 weeks in a random cross-over fashion.After each period a daily blood glucose profile has been obteined. Results are the following:Indobufen in the dose of 200 mg every 12 hours has an hypoglycemic effect. This side effect can be dangerous in patients already treated with hypoglycemic agents, but can be usefull as a single drug therapy for aged patients with type 2 diabetes mellitus and atherosclerotic vascular disease.

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Kim, Jinho, et Jim S. Chen. « Effect of Inhaling Patterns on Aerosol Drug Delivery : CFD Simulation ». Dans ASME 2008 International Mechanical Engineering Congress and Exposition. ASMEDC, 2008. http://dx.doi.org/10.1115/imece2008-66685.

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Inhaled Pharmaceutical Aerosols (IPAs) delivery has great potential in treatment of a variety of respiratory diseases, including asthma, pulmonary diseases, and allergies. Aerosol delivery has many advantages. It delivers medication directly to where it is needed and it is effective in much lower doses than required for oral administration. Currently, there are several types of IPA delivery systems, including pressurized metered dose inhaler (pMDI), the dry powder inhaler (DPI), and the medical nebulizer. IPAs should be delivered deep into the respiratory system where the drug substance can be absorbed into blood through the capillaries via the alveoli. Researchers have proved that most aerosol particles with aerodynamic diameter of about 1–5 μm, if slowly and deeply inhaled, could be deposited in the peripheral regions that are rich in alveoli [1–3]. The purpose of this study is to investigate the effects of various inhaling rates with breath-holding pause on the aerosol deposition (Dp = 0.5–5 μm) in a human upper airway model extending from mouth to 3rd generation of trachea. The oral airway model is three dimensional and non-planar configurations. The dimensions of the model are adapted from a human cast. The air flow is assumed to be unsteady, laminar, and incompressible. The investigation is carried out by Computational Fluid Dynamics (CFD) using the software Fluent 6.2. The user-defined function (UDF) is employed to simulate the cyclic inspiratory flows for different IPA inhalation patterns. When an aerosol particle enters the mouth respiratory tract, its particles experience abrupt changes in direction. The secondary flow changes its direction as the airflow passes curvature. Intensity of the secondary flow is strong after first bend at pharynx and becomes weaker after larynx. In flow separation, a particle can be trapped and follow the eddy and deposit on the surface. Particle deposition fraction generally increases as particle size and inhaling airflow velocity increase.

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Okun', Dmitriy. « FORMAL REPRESENTATION OF KNOWLEDGE ABOUT MEDICAMENTAL THERAPY FOR ISCHEMIC HEART DISEASES (detail) ». Dans XIV International Scientific Conference "System Analysis in Medicine". Far Eastern Scientific Center of Physiology and Pathology of Respiration, 2020. http://dx.doi.org/10.12737/conferencearticle_5fe01d9bce39f8.78028503.

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The paper describes a fragment of the knowledge base of drug therapy for ischemic heart disease, hosted on the IACPaaS platform. Generally accepted medical terminology is used in the formation of knowledge.

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Canzian, Kássia Braga, Marcella Canato Toloi, David Vargas Freitas Teixeira, Vanessa de Freitas Moreira, Amanda Freitas Alves, Eric Dupont, Fernanda Maria Gonçalves de Sousa Moura, Isabela de Almeida Stella, Thiago Ivan Vilchez Santillan et Herval Ribeiro Soares Neto. « Chronic paraneoplastic polyradiculoneuropathy during colorectal cancer : a case report ». Dans XIV Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2023. http://dx.doi.org/10.5327/1516-3180.141s1.633.

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A 70-year-old woman, four months before admission in our Hospital started with hypoesthesia in the hands, progressing to the lower limbs, followed by sensory ataxia and decreased strength, with frequent falls, losing 8 kg in that interim. The electroneuromyography demonstrated a pattern compatible with chronic demyelinating polyradiculoneuropathy (CIDP). Pulse therapy (PT) with Methylprednisolone was administered, with remission of symptoms. She underwent neoplastic investigation, being diagnosed with moderately differentiated and invasive sigmoid adenocarcinoma (SA), with indication for colectomy (CTC). No other solid tumors (ST) more commonly related to CIDP were found. Onconeural antibodies were not evidenced by blood analysis. 5 days after treatment, she has returned to her sensory-motor clinical condition, now attacking the bulbar muscles, developing dysphagia and dyspnea, requiring orotracheal intubation (OTI) and mechanical ventilation. Submitted to drug therapy with Intravenous Human Immunoglobulin and new PT for five days, with progressive improvement in strength, being extubated 11 days after OTI. As disease-modifying therapy, Rituximab was administered, one month before CTC. The association between SA and the development of CIDP was infrequently reported in the literature, lacking data that correlate the pathophysiology of this paraneoplastic (PNP) syndrome. Immunomodulatory therapy has an impact on the functional recovery of the patient and on preventing the progression of the symptoms, but the definitive treatment is CTC. Despite the low prevalence, the search for ST of the gastrointestinal tract should be included in PNP screening in the face of a recent diagnosis of CIDP, aiming at early identification and treatment in the initial stages, with an impact on oncological and neurological prognosis.

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Sheenkova, M. V. « ON THE PATHOGENESIS OF GASTRODUODENAL ZONE LESIONS IN VARIOUS VARIANTS OF DRUG THERAPY FOR OCCUPATIONAL RESPIRATORY DISEASES ». Dans The 16th «OCCUPATION and HEALTH» Russian National Congress with International Participation (OHRNC-2021). FSBSI “IRIOH”, 2021. http://dx.doi.org/10.31089/978-5-6042929-2-1-2021-1-575-578.

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Abstract. A survey of workers of large industrial enterprises with occupational diseases of the respiratory system was conducted to assess the dependence of the risk of damage to the upper gastrointestinal tract on the features of pharmacological therapy of respiratory pathology. The specificity of the pathogenesis of gastric and duodenal lesions associated with the properties of drug treatment of occupational respiratory diseases was revealed.

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Rapports d'organisations sur le sujet "Mouth diseases – drug therapy"

Grueso-Navarro, Elena, Leticia Rodríguez-Alcolado, Ángel Arias, Emilio J. Laserna-Mendieta et Alfredo J. Lucendo. Influence of HLA-DQA1*05 allele in the response to anti-TNFα drugs in inflammatory bowel diseases. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, février 2023. http://dx.doi.org/10.37766/inplasy2023.2.0076.

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Review question / Objective: Do patients with inflammatory bowel disease and treated with any anti-TNFα drug who had the HLA-DQA1*05 allele (in heterozygosis or homozygosis) have lower response or persistence to those drugs than patients without HLA-DQA1*05 allele? Condition being studied: Inflammatory bowel diseases (IBD), which includes Crohn’s disease (CD) and ulcerative colitis (UC), is a chronic inflammatory condition that may affect any part of the digestive tract (CD) or be limited to the colon (UC). While the specific aetiology of IBD remains unknown, it is believed to involve a complex impairment in the immunity of the gut mucosa due to a combination of several genetic and environmental factors, being the microbiota one of the latest that more attraction has received in recent years. Symptoms of IBD (such as abdominal pain, diarrhoea, fever, tiredness or rectal bleeding) may be either constant or alternate between periods of limited disease activity and flares with remarkable presence of symptoms. As IBD is associated with significant morbidity and disability, pharmacological treatment is required in most cases, especially in CD, aimed at reducing the inflammatory response and attenuating the activity of the immune system. In the moderate and severe forms of the disease, therapy is usually based on immunosuppressant and/or biological drugs. Among the latest, anti-TNFα drugs (infliximab or adalimumab) are normally chosen as the initial biological therapy.

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LI, jianhong, Zhuang LI, Yalin SHE et Guohua LIN. Assessment of acupuncture for treating herpes zoster:a protocol for an umbrella systematic review and meta analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, avril 2022. http://dx.doi.org/10.37766/inplasy2022.4.0010.

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Review question / Objective: Patients who suffer from HZ in line with the consensus of Chinese experts will be included, regardless of sex, race and time of onset . Those who diagnosed with PHN, auto-immune diseases, pregnant women will be excluded.Acupuncture, electroacupuncture, fire needle, skin acupuncture, plum blossom needle, auriculo-acupuncture all these such therapies in treating herpes zoster will be included.The control group’s treatment includes drug therapy (such as antiviral acyclovir nutritional nerve medicine or traditional Chinese medicine, etc.) ，sham acupuncture, placebo, no treatment, and so on except acupuncture therapy. efficacy rate (with reference to the guiding principles of Clinical Research of New drugs in China (trial)).pain evaluation (pain relief time, pain intensity, visual analogue score, VAS), incidence of residual neuralgia PHN.

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Tang, Jiqin, Gong Zhang, Jinxiao Xing, Ying Yu et Tao Han. Network Meta-analysis of Heat-clearing and Detoxifying Oral Liquid of Chinese Medicines in Treatment of Children’s Hand-foot-mouth Disease：a protocol for systematic review. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, janvier 2022. http://dx.doi.org/10.37766/inplasy2022.1.0032.

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Review question / Objective: The type of study was clinical randomized controlled trial (RCT). The object of study is the patients with HFMD. There is no limit to gender and race. In the case of clear diagnosis standard, curative effect judgment standard and consistent baseline treatment, the experimental group was treated with pure oral liquid of traditional Chinese medicine(A: Fuganlin oral liquid, B: huangzhihua oral liquid, C: Lanqin oral liquid, D: antiviral oral liquid, E: Huangqin oral liquid, F: Pudilan oral liquid, G: Shuanghuanglian oral liquid.)and the control group was treated with ribavirin or any oral liquid of traditional Chinese medicine. The data were extracted by two researchers independently, cross checked and reviewed according to the pre-determined tables. The data extraction content is (1) Basic information (including the first author, published journal and year, research topic). (2) Relevant information (including number of cases, total number of cases, gender, age, intervention measures, course of treatment of the experimental group and the control group in the literature). (3) Design type and quality evaluation information of the included literature. (4) Outcome measures (effective rate, healing time of oral ulcer, regression time of hand and foot rash, regression time of fever, adverse reactions.). The seven traditional Chinese medicine oral liquids are comparable in clinical practice, but their actual clinical efficacy is lack of evidence-based basis. Therefore, the purpose of this study is to use the network meta-analysis method to integrate the clinical relevant evidence of direct and indirect comparative relationship, to make quantitative comprehensive statistical analysis and sequencing of different oral liquid of traditional Chinese medicine with the same evidence body for the treatment of the disease, and then to explore the advantages and disadvantages of the efficacy and safety of different oral liquid of traditional Chinese medicine to get the best treatment plan, so as to provide reference value and evidence-based medicine evidence for clinical optimization of drug selection. Condition being studied: Hand foot mouth disease (HFMD) is a common infectious disease in pediatrics caused by a variety of enteroviruses. Its clinical manifestations are mainly characterized by persistent fever, hand foot rash, oral herpes, ulcers, etc. Because it is often found in preschool children, its immune system development is not perfect, so it is very vulnerable to infection by pathogens and epidemic diseases, resulting in rapid progress of the disease. A few patients will also have neurogenic pulmonary edema Meningitis, myocarditis and other serious complications even lead to death, so effectively improve the cure rate, shorten the course of disease, prevent the deterioration of the disease as the focus of the study. In recent years, traditional Chinese medicine has played an important role in the research of antiviral treatment. Many clinical practices have confirmed that oral liquid of traditional Chinese medicine can effectively play the role of antiviral and improve the body's immunity.

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