Littérature scientifique sur le sujet « Morpholino Chemistry »
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Articles de revues sur le sujet "Morpholino Chemistry"
Huber, Gerald, Annette Schier et Hubert Schmidbaur. « The Stereochemistry of Chloro-bis(N-morpholino)phenylsilane ». Zeitschrift für Naturforschung B 54, no 1 (1 janvier 1999) : 18–20. http://dx.doi.org/10.1515/znb-1999-0106.
Texte intégralPaul, Sibasish, et Marvin H. Caruthers. « Synthesis of Backbone-Modified Morpholino Oligonucleotides Using Phosphoramidite Chemistry ». Molecules 28, no 14 (13 juillet 2023) : 5380. http://dx.doi.org/10.3390/molecules28145380.
Texte intégralHao, Xue-chen, Jiu-fu Lu, Ye Chen, Yang Wang, Shi Ding et Ju Liu. « Synthesis, Crystal Structure and Antitumour Activity of 3-Amino-N-(5-Fluoro-2-Methylphenyl)-4-Morpholino-1H-Indazole-1-Carboxamide ». Journal of Chemical Research 41, no 11 (novembre 2017) : 624–26. http://dx.doi.org/10.3184/174751917x15065183733178.
Texte intégralTang, Zhi-hua, et Wei-Jun Fu. « Synthesis, Crystal Structure and Antitumour Activity of 3-Amino-4-Morpholino-1H-Indazol-1-yl(3-Fluorophenyl)Methanone ». Journal of Chemical Research 42, no 11 (novembre 2018) : 552–55. http://dx.doi.org/10.3184/174751918x15402939385990.
Texte intégralLu, Jiu-fu, Ling-xia Jin, Hong-guang Ge, Juan Song, Cai-bin Zhao, Xiao-hua Guo, Si-yu Yue et Li Li. « Synthesis, Crystal Structure and Antitumour Activity of 4-(3-Amino-4-Morpholino-1H-Indazole-1-Carbonyl)Benzonitrile ». Journal of Chemical Research 42, no 6 (juin 2018) : 309–12. http://dx.doi.org/10.3184/174751918x15287920661730.
Texte intégralJi, Xiao-hui, Ling-xia Jin, Cai-bin Zhao, Nan Zheng, Juan Song, Hong-guang Ge, Quan Liu et Jiu-fu Lu. « Synthesis, Crystal Structure and Antitumour Activity of 3-Amino-N-[4-chloro-3-(Trifluoromethyl)Phenyl]-4-Morpholino-1H-Indazole-1-Carboxamide ». Journal of Chemical Research 42, no 10 (octobre 2018) : 504–7. http://dx.doi.org/10.3184/174751918x15380423621264.
Texte intégralLu, Jiu-fu, Xing-long Zhou, Yu-hang Xu, Si-yu Yue, Xiao-hui Ji, Nan Zheng et Ling-xia Jin. « Synthesis, Crystal Structure, and Biological Activity of 3-Amino-4-Morpholino-N-[2-(Trifluoromethoxy)Phenyl]-1H-Indazole-1-Carboxamide ». Journal of Chemical Research 41, no 9 (septembre 2017) : 526–28. http://dx.doi.org/10.3184/174751917x15033157981988.
Texte intégralRádl, Stanislav, et Pavel Hradil. « Synthesis of some 1-alkyl-1,4-dihydro-4-oxo-1,7-naphthyridine-3-carboxylic acids ». Collection of Czechoslovak Chemical Communications 56, no 11 (1991) : 2420–29. http://dx.doi.org/10.1135/cccc19912420.
Texte intégralTiravia, Martina, Federica Sabuzi, Francesca Valentini, Valeria Conte et Pierluca Galloni. « 3-Morpholino-7-[N-methyl-N-(4′-carboxyphenyl)amino]phenothiazinium Chloride ». Molbank 2022, no 4 (14 novembre 2022) : M1493. http://dx.doi.org/10.3390/m1493.
Texte intégralBasha, S. Farook, et M. Syed Ali Padusha. « Ultrasonic Studies on the Nature of Molecular Interaction of Synthesized Mannich Bases in DMSO at Different Temperatures ». Asian Journal of Chemistry 31, no 4 (27 février 2019) : 960–64. http://dx.doi.org/10.14233/ajchem.2019.21893.
Texte intégralThèses sur le sujet "Morpholino Chemistry"
Sukackienė, Zita. « Investigation of peculiarities of cobalt and its alloys electroless deposition ». Doctoral thesis, Lithuanian Academic Libraries Network (LABT), 2014. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2014~D_20140701_110312-91991.
Texte intégralIškilus naujiems technologiniams uždaviniams, chemines dangas kobalto pagrindu, pradėta naudoti mikroelektronikoje ir mikromechanikoje siekiant sudaryti apsauginį sluoksnį vario migracijai integralinėse schemose. Varis turi mažą specifinę varžą, tačiau turi ir keletą trūkumų, tokių kaip blogas korozinis atsparumas ir aukštas difuzijos koeficientas į Si ir SiO2, bei kitas medžiagas. Šios problemos gali būti sumažintos naudojant ploną barjerinį sluoksnį, apsaugantį nuo vario difuzijos. Tam tiktų CoP bei CoB sluoksnių barjerinės savybės, kurias galima pagerinti įvedant volframą. Šiuo metu tokie tyrimai vyksta daugelyje šalių. Taip pat pastaruoju metu skiriamas didelis dėmesys naujų medžiagų paieškai, kurios būtų taikomos tiesioginiuose borohidrido kuro elementuose katalizatoriais borhidrido oksidacijos reakcijai. Mūsų darbo tikslas ištirti kobalto dangų cheminio nusodinimo glicininiuose tirpaluose ypatumus, reduktoriais naudojant natrio hipofosfitą ir morfolino boraną, bei nustatyti gaunamų dangų sudėtį ir jų panaudojimo galimybes barjerinių sluoksnių formavimui ant vario bei taikymui kuro elementų gamybai. Nustatyta, kad naudojant reduktoriumi hipofosfitą didinant tirpalų pH, CoP ir CoWP dangų nusėdimo greitis ir P kiekis jose didėja. Parinkus tinkamas sąlygas buvo gautos kokybiškos kobalto dangos, į kurias patenka nuo 2,9 iki 6,3 at.% P ir nuo 3 iki 5 at.% W. Nustatyta, kad dikarboninės rūgštys gerina tirpalų buferines savybes, pagreitina kobalto dangų nusėdimą ir didina... [toliau žr. visą tekstą]
Sukackienė, Zita. « Kobalto ir jo lydinių cheminio nusodinimo ypatumų tyrimas ». Doctoral thesis, Lithuanian Academic Libraries Network (LABT), 2014. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2014~D_20140701_110300-61887.
Texte intégralAs new technological tasks arise, electroless coatings on the basis of cobalt have come into use in microelectronics and micromechanics in order to form a protective layer against copper migration in integral schemes. Copper possesses a low specific resistance, however it also has some disadvantages, such as a low corrosion resistance and a high diffusion coefficient into So and SiO2 as well as into other substances. These problems can be diminished by using a thin barrier layer protecting from copper diffusion. The barrier properties of CoP and CoB layers which can be further improved by addition of tungsten would be suited for this purpose. At present, investigations of this kind are being carried out in many countries. Recently much attention is given to the search of new substances, which could be used in direct borohydride fuel cells as catalysts for the borohydride oxidation reaction. The aim of our work was to investigate the peculiarities of electroless cobalt coatings deposition in glycine solutions using sodium hypophosphite and morpholine borane as reducing agents, as well as to determine the composition of the coatings obtained and the possibilities of their employment for the formation of barrier layers on copper and application for fuel cells production. It has been determined that using hypophosphite as a reducing agent the rate of CoP and CoWP coatings deposition and the quantity of P in them increases with increase in solution pH. After appropriate... [to full text]
Guardado, Puentes Julian. « Trans diequatorially fused 3',3'-Diphenyl-2'-morpholinone derivatives of 2-Amino-2-deoxy-D-glucose ». Scholarly Commons, 1985. https://scholarlycommons.pacific.edu/uop_etds/2113.
Texte intégralDuchamp, Edouard. « Nouvelles exploitations des tétrazoles comme précurseurs en synthèse organique : accès aux morpholines, cyanamides et produits naturels ». Thesis, 2021. http://hdl.handle.net/1866/25560.
Texte intégralNitrogen-containing rings are core entities in the living world. This theme is conveyed in the manuscript through tetrazoles and morpholines. Morpholines are saturated azacycles possessing numerous physico-chemical and structural properties, which makes them a motif of interest in medicinal chemistry. The impact of morpholines is even more important as pharmaceutical industries try to avoid overuse of unsaturated rings in favor of saturated motifs that allow for more complex structures in the three dimensions. Therefore, development of new methods to access morpholines is an ongoing activity in many laboratories. The approach presented herein relies on the hydride reduction of oxabicyclic tetrazoles to morpholines. A detailed mechanism of the reductive cleavage of the tetrazole unit is presented. Cyanamides are endowed with an ambident electronic character that adds value to this functional group. They are widely used in drug design as covalent inhibitors. Even though cyanamides were discovered in late 19th century, their synthesis has traditionally relied on the cyanation of amines using toxic cyanide reagents. 1-Substituted 5-metalotetrazoles undergo rapid cycloreversion releasing dinitrogen and forming N-metalated cyanamide salts. The salts can be isolated or alkylated in situ, providing a new method for accessing cyanamides without the use of cyanide reagents. The obtained cyanamides could be subjected to an addition reaction with organolithium reagents, thereby yielding novel amidines. The alkaloid Polygonapholine is a 2,6-disubstituted morpholine isolated in 1997. The reported structure has never been confirmed, nor has the natural product been synthesized in the laboratory. Efforts towards its total synthesis and stereochemical confirmation is presented in the last chapter of the thesis.
Hocine, Sofiane. « Design et synthèse des composés azabicycliques contraints : de la chimie médicinale à la catalyse ». Thesis, 2020. http://hdl.handle.net/1866/24767.
Texte intégralAzacycles such as morpholines and pyrrolidines, are very widespread in chemistry, especially in the fields of organocatalysis and medicinal chemistry. This thesis will deal with constrained analogues of those azacycles, which, depending on their structures, can modulate the properties of certain drugs or the selectivity of certain reactions. The case of haloperidol, which is known for its activity on the dopamine D2 and D4 receptors, is at the center of the first part of this thesis, in which new constrained analogs of the 2-oxa-5-azabicyclo type [2.2.2] octane have been developed to overcome its metabolic stability problems. In a second part, the synthesis of two new bridged morpholine-proline chimeras are reported. Their rigid structures allow the lone pairs on the nitrogen and oxygen atoms to be oriented in spatially different "East-West" and "North-East" directions, respectively. In combination with the presence of a carboxylic acid, the electronic properties of these compounds could be useful in the context of the design of biologically relevant peptidomimetics. Quantitative estimations of the basicity of the nitrogen atoms were obtained using DFT analysis. In the third part of this thesis, the synthesis of new oxabicyclic pyrrolidines is described. Cyclopentan[c]pyrroles are widely encountered and known for their analgesic properties. The Servier laboratories have synthesized derivatives with substituents at positions 4 and 5, exhibiting good activities as 7 nicotinic ligands, but problems of hERG inhibition. In order to obtain less lipophilic compounds and therefore overcome the problems of hERG inhibition, new oxygenated analogs of the furo[2,3-c]pyrrole type have been developed by different synthetic routes. These new compounds were obtained in enantiomerically enriched forms, using enzymatic resolution. Proline has been widely used in recent years as an organocatalyst in asymmetric transformations such as aldolizations or Michael additions The success of this motif, has inspired synthesis of derivatives, such as 4,5-methanoprolines, which were first reported by Hanessian in 1997, and shown to be effective as organocatalysts in the Hajos-Parrish and other reactions. The last parts of this thesis develop further these studies by the synthesis of new 4,5-ethanoprolines which act as a catalysts in the Hajos-Parrish reaction and the asymmetric catalytic addition of nitroalkanes to cyclic enones. A DFT study was carried out to explain the reversal of selectivity observed for the new catalysts in Hajos-Parrish reaction and to investigate formation of a reactive enamine in the mechanism.
Chapitres de livres sur le sujet "Morpholino Chemistry"
Palacio-Castañeda, Valentina, Roland Brock et Wouter P. R. Verdurmen. « Generation of Protein-Phosphorodiamidate Morpholino Oligomer Conjugates for Efficient Cellular Delivery via Anthrax Protective Antigen ». Dans Methods in Molecular Biology, 129–41. New York, NY : Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-2010-6_8.
Texte intégralKumari, Archana, et Rajesh K. Singh. « Morpholine : Pharmacophore Modulating Pharmacokinetic Properties of Anticancer Leads ». Dans Key Heterocyclic Cores for Smart Anticancer Drug–Design Part II, 137–73. BENTHAM SCIENCE PUBLISHERS, 2022. http://dx.doi.org/10.2174/9789815040043122020008.
Texte intégralDeRosa, Thomas F. « Morpholines ». Dans Advances in Synthetic Organic Chemistry and Methods Reported in US Patents, 399–400. Elsevier, 2006. http://dx.doi.org/10.1016/b978-008044474-1/50054-2.
Texte intégralKumbhar, A. G., S. Rangarajan, S. V. Narasimhan, P. K. Mathur et K. S. Venkateswarlu. « Paper 100. Evaluation of condensate demineralisation using morpholine form of the cation exchanger ». Dans WATER CHEMISTRY OF NUCLEAR REACTOR SYSTEMS 4, 363–67. Thomas Telford Publishing, 1986. http://dx.doi.org/10.1680/wconrs4v1.03705.0074.
Texte intégralDauvois, V., I. Lambert, D. Desmoulins et F. Nordmann. « Paper 101. Laboratory and plant investigations on decomposition products of morpholine in the secondary system of French PWRs ». Dans WATER CHEMISTRY OF NUCLEAR REACTOR SYSTEMS 4, 372–75. Thomas Telford Publishing, 1986. http://dx.doi.org/10.1680/wconrs4v1.03705.0075.
Texte intégralLambert, Tristan H. « C–O Ring Formation ». Dans Organic Synthesis. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780190646165.003.0044.
Texte intégralActes de conférences sur le sujet "Morpholino Chemistry"
Saleh, Amer F., Andrey A. Arzumanov, Haifang Yin, Corinne Betts, Suzan Hammond, Matthew J. A. Wood et Michael J. Gait. « Enhancement of exon skipping and dystrophin production by 3'-peptide conjugates of morpholino (PMO) oligonucleotides in a mdx mouse model of Duchenne muscular dystrophy ». Dans XVth Symposium on Chemistry of Nucleic Acid Components. Prague : Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 2011. http://dx.doi.org/10.1135/css201112292.
Texte intégralTesta, Maria Luisa, Elena Zaballos-Garcia et Ramón Zaragozá. « Solvent-mediated reactivity of b-aminoalcohols against dialkyloxalate : synthesis of tetrasubstituted oxalamide and/ or morpholin-2,3-dione derivatives. » Dans The 12th International Electronic Conference on Synthetic Organic Chemistry. Basel, Switzerland : MDPI, 2008. http://dx.doi.org/10.3390/ecsoc-12-01198.
Texte intégralBrychtova, Katerina, Jozef Csollei, Josef Jampilek, Radka Opatrilova, Lukas Placek, Barbora Slaba et Sylva Dittrichova. « Synthesis of Esters of 6-(2,5-Dioxopyrrolidin-1-yl)-2- (morpholin-4-yl)hexanoic Acid as Potential Transdermal Penetration Enhancers ». Dans The 13th International Electronic Conference on Synthetic Organic Chemistry. Basel, Switzerland : MDPI, 2009. http://dx.doi.org/10.3390/ecsoc-13-00210.
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