Littérature scientifique sur le sujet « Molecules - Biological Interests »
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Articles de revues sur le sujet "Molecules - Biological Interests"
Verma, Amita, Sunil Joshi et Deepika Singh. « Imidazole : Having Versatile Biological Activities ». Journal of Chemistry 2013 (2013) : 1–12. http://dx.doi.org/10.1155/2013/329412.
Texte intégralBilal, Muhammad, Leonardo Vieira Nunes, Marco Thúlio Saviatto Duarte, Luiz Fernando Romanholo Ferreira, Renato Nery Soriano et Hafiz M. N. Iqbal. « Exploitation of Marine-Derived Robust Biological Molecules to Manage Inflammatory Bowel Disease ». Marine Drugs 19, no 4 (30 mars 2021) : 196. http://dx.doi.org/10.3390/md19040196.
Texte intégralWehbe, Rim, Jacinthe Frangieh, Mohamad Rima, Dany El Obeid, Jean-Marc Sabatier et Ziad Fajloun. « Bee Venom : Overview of Main Compounds and Bioactivities for Therapeutic Interests ». Molecules 24, no 16 (19 août 2019) : 2997. http://dx.doi.org/10.3390/molecules24162997.
Texte intégralBoss, Alan P., William M. Irvine, Karen J. Meech, Cristiano B. Cosmovici, Pascale F. Ehrenfreund, David W. Latham, David Morrison et Stephane Udry. « COMMISSION 51 : BIOASTRONOMY ». Proceedings of the International Astronomical Union 4, T27A (décembre 2008) : 179–80. http://dx.doi.org/10.1017/s1743921308025453.
Texte intégralMurad, Ferid. « Discovery of Some of the Biological Effects of Nitric Oxide and its Role in Cell Signaling ». Bioscience Reports 19, no 3 (1 juin 1999) : 133–54. http://dx.doi.org/10.1023/a:1020265417394.
Texte intégralMurad, Ferid. « Discovery of Some of the Biological Effects of Nitric Oxide and its Role in Cell Signaling ». Bioscience Reports 24, no 4-5 (10 août 2004) : 452–74. http://dx.doi.org/10.1007/s10540-005-2741-8.
Texte intégralWang, Yu-Huan, Qian-Fan Yang, Xiao Lin, Die Chen, Zhi-Yin Wang, Bin Chen, Hua-Yi Han et al. « G4LDB 2.2 : a database for discovering and studying G-quadruplex and i-Motif ligands ». Nucleic Acids Research 50, no D1 (29 octobre 2021) : D150—D160. http://dx.doi.org/10.1093/nar/gkab952.
Texte intégralDi Costanzo, Luigi, et Barbara Panunzi. « Visual pH Sensors : From a Chemical Perspective to New Bioengineered Materials ». Molecules 26, no 10 (16 mai 2021) : 2952. http://dx.doi.org/10.3390/molecules26102952.
Texte intégralSheth, Tejas, C. S. Pitchumoni et Kiron M. Das. « Management of Musculoskeletal Manifestations in Inflammatory Bowel Disease ». Gastroenterology Research and Practice 2015 (2015) : 1–11. http://dx.doi.org/10.1155/2015/387891.
Texte intégralTarley, Cesar. « Chemical Imprinting Technology Applied to Analytical Chemistry : Current Status and Future Outlook in Brazil ». Brazilian Journal of Analytical Chemistry 9, no 35 (11 avril 2022) : 7–11. http://dx.doi.org/10.30744/brjac.2179-3425.letter.crtarley.n35.
Texte intégralThèses sur le sujet "Molecules - Biological Interests"
Strawbridge, Sharon Mary. « Redox-active sensors for molecules of biological interest ». Thesis, University of Exeter, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.414263.
Texte intégralBarbany, Puig Montserrat. « Three Dimensional Simulitary of Molecules with biological interest on the basis of molecular interaction potentials ». Doctoral thesis, Universitat Pompeu Fabra, 2006. http://hdl.handle.net/10803/7146.
Texte intégralL'èxit d'aquestes tècniques depen críticament de la qualitat de la descripció molecular. En aquest sentit, metodologies basades en potencials d'interacció molecular (MIP) són eines útils per la comparació de compostos que presenten comportaments biològics semblants.
Aquest projecte desenvolupa eines per comparar molècules basades en la caracterització de llurs MIPs. El programa de similaritat molecular MIPsim ha estat desenvolupat i aplicat a diferents problemes biològics.
Aquesta tesi consisteix en quatre estudis científics que mostren l'ús del MIPSim en aliniament molecular, catalisi enzimàtica, en acoratge de molècules dins el lligand i en estudis 3D-QSAR.
One of the most promising areas in biomedical and pharmaceutical research is computer assisted molecular design, which tries to stablish relationships between physicochemical properties and biological activity.
The success of these techniques depends critically on the quality of the molecular description. In this sense, methodologies based on molecular interaction potentials (MIP) are useful tools for the comparison of compounds displaying related biological behaviours.
This project aims to develop tools to compare 'molecules based on the characterization 'of their MIPs. To this end, the molecular similarity program MIPSim has been further developed and applied to different biological problems.
This thesis consists on four scientific studies showing the use of MIPSim for molecular alignment, enzymatic catalysis, ligand-protein docking and 3D-QSAR analyses.
Wood, Stephen Derek. « Crystallographic studies of molecules of biological and chemical interest ». Thesis, Liverpool John Moores University, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.337886.
Texte intégralPinto, Rui Montenegro Val-do-Rio. « Photoelectron spectroscopy of nitrogen containing molecules of biological and industrial interest ». Doctoral thesis, Faculdade de Ciências e Tecnologia, 2011. http://hdl.handle.net/10362/7077.
Texte intégralCastrovilli, Mattea Carmen <1985>. « Elemetary processes of radiation damage in organic molecules of biological interest ». Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2014. http://amsdottorato.unibo.it/6386/1/Castrovilli_MatteaCarmen_tesi.pdf.
Texte intégralCastrovilli, Mattea Carmen <1985>. « Elemetary processes of radiation damage in organic molecules of biological interest ». Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2014. http://amsdottorato.unibo.it/6386/.
Texte intégralRIVA, BENEDETTA. « investigating the functionalization of colloidal nanoparticles with small molecules of biological interest ». Doctoral thesis, Università degli Studi di Milano-Bicocca, 2017. http://hdl.handle.net/10281/153282.
Texte intégral1) Developement of radio-labelled SNPs for the targeted detection and treatment of Her2-positive breast cancer.Aim of this work was to develop a SNP-based system loaded with radioactive/fluorescent probes and functionalized with the half-chain of a monoclonal antibody, Trastuzumab, which specifically recognizes the human epidermal growth factor receptor 2 (Her2), overexpressed in 25-30% of human breast tumours. The silica core was covalently functionalized with FITC, further protected by a 10 nm silica shell and stabilized in saline buffer by means of differently terminated PEGs (SNP). Such nanoparticles were then conjugated with Trastuzumab half-chain (SNP-TZ). Finally, both SNP and SNP-TZ were derivatized with nitrilo-triacetic acid and labelled with 99mTc-Tricarbonyl complex, giving rise to SNP-NTA and SNP-NTA-TZ NPs. The functionalization steps were monitored both by size and z-potential measurements and the impact of each chemical moietiy on the NP behaviour in cells was assessed in prelabeling in vitro experiments comparing SNP, SNP-NTA, SNP-TZ and SNP-NTA-TZ. Targeting specificity of TZ-functionalized or TZ-free SNPs was studied in in vitro, in vivo and ex vivo experiments, both employing fluorescence and radionuclide techniques. Our results suggested that active targeting provided higher efficiency and selectivity in tumor detection compared to passive diffusion, confirming that our synthetic strategy provided stable nanoconjugates and did not affect their binding efficiency to HER2 expressing cells.2) Development of doxorubicin-loaded nonporous SNPs. Nonporous SNPs were chosen as the starting point to produce different drug carriers, bearing the well-known anticancer drug doxorubicin. Different silica nanoformulations containing the well-known anticancer drug doxorubicin were compared: OuterDox NPs, in which doxorubicin was covalently linked on the silica surface, InnerDox NPs, in which the chemotherapeutic was covalently immobilized in the core of the same particles and DoubleDox NPs, containing the drug both externally and internally.The nanoformulations were studied in terms of carrier degradation and payload release in physiological conditions.The in vitro efficiency was also investigated.3)Development of glutathione-sensitive apoferritin NPs for the controlled delivery of luciferin.Although bioluminescence imaging has been successfully used in a variety of applications to obtain information regarding biological processes in vivo, the detection of photon emission is limited by the short half-life of luciferin (less than 30 minutes), its modest cell penetration and inhomogeneous diffusion into different tissues. In this context, we developed a glutathione-sensitive NP for stimuli-responsive release of luciferin within cancer cells. The nanoconjugate bears luciferin by means of a disulfide containing linker (Luc-linker), which, in the presence of a reducing agent, undergoes an intramolecular cyclization reaction that results in the release of free luciferin. The correct luciferin release mechanism was checked in cell-free in vitro bioluminescence tests: an abundant photon production was detected when Luc-linker was preincubated with DTT and then reacted with luciferase, while no light emission was seen without DTT pretreatment. Luc-linker was then attached to apoferritin (HFn) NP surface, exploiting the free thiol groups of cysteine residues, leading to Luc-linker@HFn NPs.After the conjugation, an HPLC method was developed for the quantification of conjugation efficiency and drug loading, requiring a preliminary separation of the linker from the hosting HFn NPs. The Luc-linker@HFn was then tested in vitro to initially elucidate the bioluminescent kinetics and compare the luminous signal to the one of nanoparticle-free luciferin.
Alexopoulos, Eftichia. « Crystallographic and modeling studies of intermolecular interactions of biological interest ». Doctoral thesis, [S.l.] : [s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=972659137.
Texte intégralSoussi, Jordane. « Contribution to the study of heat relaxation in nanostructures of biological interest ». Thesis, Université Paris-Saclay (ComUE), 2015. http://www.theses.fr/2015SACLC013/document.
Texte intégralIn medicine, nanotechnologies give the opportunity to create new care practices such as local hyperthermia and targeted drug delivery. These applications imply new scientific challenges concerning the design of nanodevices and the properties of their biological environment. In this thesis, we have analysed several aspects of heat relaxation of such systems. We have used both Molecular Dynamics numerical simulations and Fluorescence-lifetime imaging microscopy experiments. We present a study of heat transfer from a solvated nanoparticle and show that attaching a polymer on its surface reduces the thermal resistance between the particle and its aqueous environment. We have modelled lipid bilayers to compute their dielectric properties and their viscosity have been investigated by fluorescence imaging. The experiments conducted on both suspended lipid membrane and giant unilamellar vesicles show that the viscosity decreases when the temperature increases and when a transmembrane voltage is applied to inducing a structural change
Sousa, Thiago Machado Mello de. « Produção de proteínas de interesse terapêutico em células de mamíferos em cultura ». reponame:Repositório Institucional da UnB, 2006. http://repositorio.unb.br/handle/10482/3228.
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As proteínas recombinantes de interesse terapêutico vêm ganhando cada vez mais espaço na indústria farmacêutica e atualmente já movimentam um mercado anual de cerca de 50 a 60 bilhões de dólares em todo o mundo. As células de mamíferos são as hospedeiras de expressão preferencialmente escolhidas no caso de proteínas que requerem um grau sofisticado de processamento pós-traducional, sendo crescente a iniciativa de identificação de novas linhagens de células, especialmente humanas, como sistemas alternativos de expressão às células utilizadas. Nosso grupo de pesquisa tem interesse na produção de antígenos para seleção de anticorpos com potencial neutralizante, especialmente os antígenos de superfície do envelope viral de HIV-1, agente etiológico da pandemia mundial de AIDS, que atualmente apresenta mais de 40 milhões de infectados. O presente trabalho teve por objetivo a avaliação preliminar das células de ducto de glândula submandibular humana (HSG) como sistema de expressão heteróloga alternativo às células de ovário de hamster chinês (CHO-K1). Comparativamente, foi avaliada a eficiência de transfecção, assim como a de expressão transiente do anticorpo quimérico anti-Z-DNA Z22, na forma recombinante de fragmento FvFc pelas duas linhagens celulares. Outro objetivo foi a produção de versões recombinantes das glicoproteínas virais de HIV-1. Os resultados apontaram as células HSG como um bom sistema alternativo para a produção de proteínas heterólogas secretadas, especialmente quando transfectadas por co-precipitação com fosfato de cálcio, sendo ainda necessários alguns ajustes, uma vez que os choques osmóticos com glicerol e DMSO, considerados pontencializadores da transfecção, mostraram-se tóxicos da forma como foram executados. Foram amplificados e clonados em vetor de expressão para células de mamíferos os segmentos gênicos correspondentes a quatro versões recombinantes das glicoproteínas do envelope viral de HIV-1 (gp160, gp140, gp120 e gp41+PS), subtipo C que, de acordo com as nossas análises, utiliza CCR5 como co-receptor. Até o presente momento, não foi possível a detecção das glicoproteínas recombinantes, expressas de forma transiente em células CHO-K1, sendo necessários ajustes, principalmente na etapa de transfecção. _______________________________________________________________________________ ABSTRACT
Recombinant therapeutic proteins have become more and more important in the pharmaceutical industry, and nowadays they are responsible for an injection of about 50 to 60 million dollar a year into the worldwide market. Animal cell cultures are the preferential expression systems for those proteins which require extensive posttranslational modifications. In this view, the identification of alternative expression systems is an issue of increasing concern, specially considering human cell lines. Our research group has been interested in the production of antigens to be used for the selection of neutralizing antibodies, particularly those antigens derived from the envelope surface of HIV-1, the etiologic agent of the pandemic infection of AIDS, which nowadays affects more than 40 million people. This work aimed the preliminary evaluation of the human salivary gland duct cells (HSG) as a heterologous expression system alternative to the Chinese hamster ovary cells (CHO-K1). The transfection efficiency for both cell lines was comparatively evaluated, as well as the transient expression of the anti-Z-DNA Z22 chimeric antibody, as a recombinant FvFc fragment. Another objective was the production of recombinant versions of HIV-1 glycoproteins. Our results pointed out to the HSG cells as a good alternative system for the production of secreted heterologous proteins, specially when transfected by co-precipitation with calcium phosphate. Some adjusts are still needed, considering that the glycerol and DMSO osmotic shocks, generally considered as transfection pontentializers, proved to be toxic in the employed protocol. The genic fragments corresponding to four recombinant versions of the HIV-1 envelope glycoproteins (gp160, gp140 gp120 and gp41+PS), subtype C, were amplified and cloned in a mammal cells expression vector. According to our analysis, this virus subtype uses CCR5 as co-receptor. So far, it was not possible to detect the recombinant glycoproteins expressed in a transient form in the CHO-K1 cells. In order to achieve this objective, some adjustments are still necessary, specially concerning the transfection protocol.
Livres sur le sujet "Molecules - Biological Interests"
Cherdanceva, Tat'yana, Vladimir Klimechev et Igor' Bobrov. Pathological and molecular biological analysis of renal cell carcinoma. Diagnosis and prognosis. ru : INFRA-M Academic Publishing LLC., 2020. http://dx.doi.org/10.12737/1020785.
Texte intégralSawyer, Donald T., et R. J. P. Williams. Oxygen Chemistry. Oxford University Press, 1992. http://dx.doi.org/10.1093/oso/9780195057980.001.0001.
Texte intégralMolecular Diagnostics and Biological Safety 2021. COVID-19 : Epidemiology, Diagnosis and Prophylaxis : Conference Abstracts. Central Research Institute for Epidemiology, 2021. http://dx.doi.org/10.36233/978-5-6045286-2-4.
Texte intégralAmos, Martyn, dir. Cellular Computing. Oxford University Press, 2004. http://dx.doi.org/10.1093/oso/9780195155396.001.0001.
Texte intégralOliveira, Alana Maria Cerqueira de. Interação parasito-hospedeiro 2. Atena Editora, 2022. http://dx.doi.org/10.22533/at.ed.707222601.
Texte intégralColloff, Matthew J. Dust Mites. CSIRO Publishing, 2009. http://dx.doi.org/10.1071/9780643100497.
Texte intégralAllendorf, Fred W., W. Chris Funk, Sally N. Aitken, Margaret Byrne, Gordon Luikart et Agostinho Antunes. Conservation and the Genomics of Populations. 3e éd. Oxford University Press, 2022. http://dx.doi.org/10.1093/oso/9780198856566.001.0001.
Texte intégralChapitres de livres sur le sujet "Molecules - Biological Interests"
Tonel, Mariana Zancan, Vivian Machado de Menezes, Ivana Zanella et Solange Binotto Fagan. « Molecules with Biological Interest Adsorbed on Carbon Nanostructures ». Dans Carbon Nanostructures, 107–22. Cham : Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-18875-1_6.
Texte intégralDurchschlag, Helmut. « Specific Volumes of Biological Macromolecules and Some Other Molecules of Biological Interest ». Dans Thermodynamic Data for Biochemistry and Biotechnology, 45–128. Berlin, Heidelberg : Springer Berlin Heidelberg, 1986. http://dx.doi.org/10.1007/978-3-642-71114-5_3.
Texte intégralBolognesi, P., P. O’Keeffe et L. Avaldi. « Soft X-ray Interaction with Organic Molecules of Biological Interest ». Dans Radiation Damage in Biomolecular Systems, 165–76. Dordrecht : Springer Netherlands, 2011. http://dx.doi.org/10.1007/978-94-007-2564-5_10.
Texte intégralHorovitz, Chaim T. « Interactions of Scandium and Yttrium with Molecules of Biological Interest ». Dans Biochemistry of Scandium and Yttrium, Part 1 : Physical and Chemical Fundamentals, 235–308. Boston, MA : Springer US, 1999. http://dx.doi.org/10.1007/978-1-4615-4313-8_6.
Texte intégralZittle, Charles A. « Reaction of Borate with Substances of Biological Interest ». Dans Advances in Enzymology - and Related Areas of Molecular Biology, 493–527. Hoboken, NJ, USA : John Wiley & Sons, Inc., 2006. http://dx.doi.org/10.1002/9780470122570.ch9.
Texte intégralDryhurst, Glenn. « Electrochemistry of Low Molecular Weight Organic Compounds of Biological Interest ». Dans Comprehensive Treatise of Electrochemistry, 131–88. Boston, MA : Springer US, 1985. http://dx.doi.org/10.1007/978-1-4613-2359-4_2.
Texte intégralBraslavsky, S. E. « Pulsed-Laser Optoacoustic and Thermal-Lensing Studies of Relaxation Processes in Biological Systems and Molecules of Biological Interest ». Dans Photoacoustic and Photothermal Phenomena, 508–13. Berlin, Heidelberg : Springer Berlin Heidelberg, 1988. http://dx.doi.org/10.1007/978-3-540-48181-2_139.
Texte intégralWentrup-Byrne, E., P. M. Fredericks, J. Aubard, J. Pantigny et G. Levi. « Particular Merits of Different Silver Colloids with Various Electrolytes, pH and Excitation Wavelengths for SERS Studies of Molecules of Biological Interest ». Dans Fifth International Conference on the Spectroscopy of Biological Molecules, 259–60. Dordrecht : Springer Netherlands, 1993. http://dx.doi.org/10.1007/978-94-011-1934-4_95.
Texte intégralMeier, Michael, et Megan J. Wilson. « Using RNA-Seq for Transcriptome Profiling of Botrylloides sp. Regeneration ». Dans Methods in Molecular Biology, 599–615. New York, NY : Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-2172-1_32.
Texte intégralSljoka, Adnan. « Structural and Functional Analysis of Proteins Using Rigidity Theory ». Dans Sublinear Computation Paradigm, 337–67. Singapore : Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-16-4095-7_14.
Texte intégralActes de conférences sur le sujet "Molecules - Biological Interests"
Sauer, M., K. H. Drexhage, K. T. Han, S. Nord et C. Zander. « Following the Dynamics of Single Oligonucleotide Molecules in Water ». Dans Laser Applications to Chemical and Environmental Analysis. Washington, D.C. : Optica Publishing Group, 1998. http://dx.doi.org/10.1364/lacea.1998.lmc.14.
Texte intégralLermer, N., M. D. Barnes, C.-Y. Kung, W. B. Whitten et J. M. Ramsey. « High-Speed Single Molecule Detection in Microdroplet Streams ». Dans Laser Applications to Chemical and Environmental Analysis. Washington, D.C. : Optica Publishing Group, 1996. http://dx.doi.org/10.1364/lacea.1996.lwb.7.
Texte intégralWang, Feng, George Maroulis et Theodore E. Simos. « Electron Momentum Spectroscopy and Its Applications to Molecules of Biological Interest ». Dans Computational Methods in Science and Engineering. AIP, 2007. http://dx.doi.org/10.1063/1.2827040.
Texte intégralChin, LiKang, Anthony Calabro et Kathleen A. Derwin. « Development and Characterization of Tyramine Substituted-Hyaluronan (TS-HA) Enriched Fascia for Rotator Cuff Repair ». Dans ASME 2010 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2010. http://dx.doi.org/10.1115/sbc2010-19553.
Texte intégralJohnston, Roger G., Stephen P. Edmondson, Shermila B. Singham et Gary C. Salzman. « Biophysical Applications of the XUV Free Electron Laser ». Dans Free-Electron Laser Applications in the Ultraviolet. Washington, D.C. : Optica Publishing Group, 1988. http://dx.doi.org/10.1364/fel.1988.fa3.
Texte intégralJuhász, Z., J. Y. Chesnel, F. Frémont, A. Hajaji, B. Sulik, Károly Tokési et Béla Sulik. « Coulomb explosion and binary encounter processes in collisions between slow ions and small molecules of biological interest ». Dans RADIATION DAMAGE IN BIOMOLECULAR SYSTEMS : Proceedings of the 5th International Conference (RADAM 2008). AIP, 2008. http://dx.doi.org/10.1063/1.3058970.
Texte intégralYan, Karen Chang, Michael Rossini, Michael Sebok et John Sperduto. « Concentration Characterization of Encapsulated Macromolecules in Electrospun Alginate Fibers Using Image Analysis ». Dans ASME 2015 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2015. http://dx.doi.org/10.1115/imece2015-52585.
Texte intégralRobinet, G., J.-Ph Rameau et J. Devillers. « Molecular mechanical (MM2) and semi empirical (PM3) comparative study of some heterocyclic compounds of biological interest ». Dans The first European conference on computational chemistry (E.C.C.C.1). AIP, 1995. http://dx.doi.org/10.1063/1.47675.
Texte intégralAnderson, Gary L., et Devendra P. Garg. « Damping and Vibration Control via Nanoscale Technologies for Defense Oriented Applications ». Dans ASME 2003 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. ASMEDC, 2003. http://dx.doi.org/10.1115/detc2003/vib-48536.
Texte intégralMills, K. L., Dongeun Huh, Shuichi Takayama et M. D. Thouless. « Adjustable Nanofluidic Channels by Tunnel Cracking of a Constrained Brittle Layer ». Dans ASME 2008 6th International Conference on Nanochannels, Microchannels, and Minichannels. ASMEDC, 2008. http://dx.doi.org/10.1115/icnmm2008-62164.
Texte intégralRapports d'organisations sur le sujet "Molecules - Biological Interests"
López-Valverde, Nansi, Javier Aragoneses, Antonio López-Valverde, Cinthia Rodríguez et Juan Manuel Aragoneses. Role in the osseointegration of titanium dental implants, of bioactive surfaces based on biomolecules : A systematic review and meta-analysis of in vivo studies. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, juin 2022. http://dx.doi.org/10.37766/inplasy2022.6.0076.
Texte intégralGurevitz, Michael, Michael E. Adams et Boaz Shaanan. Structural Elements and Neuropharmacological Features Involved in the Insecticidal Properties of an Alpha Scorpion Neurotoxin : A Multidisciplinary Approach. United States Department of Agriculture, août 1995. http://dx.doi.org/10.32747/1995.7573061.bard.
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