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Littérature scientifique sur le sujet « Molecular recognitions »

Auteur : Grafiati

Publié le 10 mars 2023

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Articles de revues sur le sujet "Molecular recognitions"

Ye, Yunpeng, Sharon Bloch et Samuel Achilefu. « Polyvalent Carbocyanine Molecular Beacons for Molecular Recognitions ». Journal of the American Chemical Society 126, n^o 25 (juin 2004) : 7740–41. http://dx.doi.org/10.1021/ja049441z.

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OKAHATA, YOSHIO. « Molecular Recognitions on a Lipid Membrane ». Sen'i Gakkaishi 46, n^o 2 (1990) : P64—P69. http://dx.doi.org/10.2115/fiber.46.p64.

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Haino, Takeharu. « Designer supramolecular polymers with specific molecular recognitions ». Polymer Journal 51, n^o 3 (21 septembre 2018) : 303–18. http://dx.doi.org/10.1038/s41428-018-0126-7.

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Tanoue, Takuji, et Eisuke Nishida. « Molecular recognitions in the MAP kinase cascades ». Cellular Signalling 15, n^o 5 (mai 2003) : 455–62. http://dx.doi.org/10.1016/s0898-6568(02)00112-2.

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Ogata, Naoya. « Supramolecular membranes for optical resolutions and molecular recognitions ». Macromolecular Symposia 77, n^o 1 (janvier 1994) : 167–75. http://dx.doi.org/10.1002/masy.19940770120.

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Zhang, Mingzhen, Jie Zheng, Ruth Nussinov et Buyong Ma. « Molecular Recognition between Aβ-Specific Single-Domain Antibody and Aβ Misfolded Aggregates ». Antibodies 7, n^o 3 (13 juillet 2018) : 25. http://dx.doi.org/10.3390/antib7030025.

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Aβ is the toxic amyloid polypeptide responsible for Alzheimer’s disease (AD). Prevention and elimination of the Aβ misfolded aggregates are the promising therapeutic strategies for the AD treatments. Gammabody, the Aβ-Specific Single-domain (VH) antibody, recognizes Aβ aggregates with high affinity and specificity and reduces their toxicities. Employing the molecular dynamics simulations, we studied diverse gammabody-Aβ recognition complexes to get insights into their structural and dynamic properties and gammabody-Aβ recognitions. Among many heterogeneous binding modes, we focused on two gammabody-Aβ recognition scenarios: recognition through Aβ β-sheet backbone and on sidechain surface. We found that the gammabody primarily uses the complementarity-determining region 3 (CDR3) loop with the grafted Aβ sequence to interact with the Aβ fibril, while CDR1/CDR2 loops have very little contact. The gammabody-Aβ complexes with backbone binding mode are more stable, explaining the gammabody’s specificity towards the C-terminal Aβ sequence.

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Süleymanoglu, Erhan. « Thermodynamics of molecular recognitions between antineoplastic drug taxol and phosphatidylcholine ». Brazilian Archives of Biology and Technology 53, n^o 6 (décembre 2010) : 1351–58. http://dx.doi.org/10.1590/s1516-89132010000600011.

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Sanjoh, Mai, Daisuke Iizuka, Akira Matsumoto et Yuji Miyahara. « Boronate Based Metal-Free Platform for Diphosphate-Specific Molecular Recognitions ». Organic Letters 17, n^o 3 (16 janvier 2015) : 588–91. http://dx.doi.org/10.1021/ol5036003.

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Mohnani, Stefan, Anna Llanes-Pallas et Davide Bonifazi. « Mastering nanostructured materials through H-bonding recognitions at interfaces ». Pure and Applied Chemistry 82, n^o 4 (20 mars 2010) : 917–29. http://dx.doi.org/10.1351/pac-con-10-01-06.

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The controlled engineering of functional architectures composed of π-systems with unusual opto-electronic properties is currently being investigated intensively from both fundamental research and technological application viewpoints. In particular, the exploitation of the supramolecular approach for the facile construction of multidimensional architectures, featuring cavities capable of hosting functional molecules, could be used in several applications, such as nanomedicine, molecular-based memory storage devices, and sensors. This paper highlights our recent strategies to use hydrogen-bonding interactions to prepare nanostructured functional architectures via the self-assembly of organic molecular modules studied at different interfaces.

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Toda, Fumio. « Crystalline inclusion complexes as media of molecular recognitions and selective reactions ». Pure and Applied Chemistry 73, n^o 7 (1 juillet 2001) : 1137–45. http://dx.doi.org/10.1351/pac200173071137.

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Hexaol host compounds which include guest molecules maximum in 1:6 ratio were prepared. Aromatic hexaol host, hexahydroxytriphenylene, was found to form chiral inclusion crystal by complexation with achiral guest molecules. Some interesting and important optical resolutions of rac-guests by inclusion complexation with a chiral host were described. When chemical reaction and the inclusion complexation procedures in a water suspension medium are combined, new economical and ecological method of the preparation of optically active compound can be established. When photochemical reactions are carried out in an inclusion crystal with a chiral host, enantioselective reactions occur, and optically active product can be obtained. Several successful reactions are described.

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Thèses sur le sujet "Molecular recognitions"

Della, Sala Paolo. « Synthesis and properties of new macrocyclic derivates ». Doctoral thesis, Universita degli studi di Salerno, 2019. http://elea.unisa.it:8080/xmlui/handle/10556/4255.

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2017 - 2018
This PhD thesis is concerned with the design, synthesis and the characterization of new macrocyclic derivatives. Development of new macrocyclic compounds is a particularly interesting because they can involve like building block in Supramolecular chemistry and Nanochemistry. In the first place, I studied the supramolecular properties of different derivatives of the resorcin[6]arenes. Crystal of Resorcin[6]arene was obtained and it reveals that in the solid state the resorcin[6]arene assembles in a twin molecular capsule able to host toluene and ethyl acetate solvent molecules. Subsequently, I have reported the first example of resorcin[6]arene-based cavitand. Sulfate bridges play a double role, both, as structural element for the preorganization of the larger resorcin[6]arene macrocycle and as functional supramolecular interacting groups. Finally, I develop a new multivalent systems resorcin[n]arene based for inhibition of glycosidases and mannosidase that are involved in the malignant transformation of cells. These derivatives were synthetized starting to a pyrrolidine-based iminosugar and resorcinarenes compounds through CuAAS cycloaddition. Biological essays showed that all the resorcinarene derivatives have a good inhibitory activity towards mannosidase enzymes. In second instance, I synthetized new Cycloparaphenylenes (CPP) derivatives to molecular recognition and optoelectronic application. Particularly about molecular recognition field, I reported the synthesis of a [8]CPP derivative incorporating an electron-rich 1,4-dimethoxybenzene ring. This is the first example of substituted CPP derivative reported in literature able to recognize pyridinium guests. Owing to the presence of the 1,4-dimethoxybenzene ring a fine-tuning of the binding abilities toward pyridinium guests was obtained with respect to the native [8]CPP macrocycle. Hybrid Calixarene-CPP derivative that combine the supramolecular features of both the hosts was synthetized and studied in molecular recognition of Na+, Li+ and K+. This derivative shows a noncommon Li+ selectivity due to a more favorable interaction between the cation and the aromatic rings of the CPP bridge. Synthesis of incorporate the 9,10-diphenyl anthracene - [8]CPP derivative was performed and were studied optical and electronical features to obtain the first example of a CPP-based emitter in photon upconversion in the presence of the of octaethylporphyrin Pd(II) complex as a sensitizer, thus widening the application fields of this class of compounds. Finally, [8]CPP and [10]CPP was tested to produce Luminescent Solar Concentrators (LSCs). The high Stokes shift of the CPP macrocycles, enables the preparation of slabs in which a low reabsorption was observed. The results here obtained show clearly the photophysical performances of the CPPbased LSC closely matches with that of the lanthanide chelates based LSC, of interest for applications in colorless LSC. [edited by Author]
XXXI ciclo

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Kirsch, Nicole. « Molecular recognition of poorly functionalised molecules with imprinted polymers ». Thesis, University of Reading, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.325167.

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Eckel, Rainer. « Single molecules and nanocrystals : molecular recognition forces and optomechanical switching ». [S.l.] : [s.n.], 2006. http://deposit.ddb.de/cgi-bin/dokserv?idn=978888227.

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Kurahashi, Takuya. « Molecular Recognition and Regioselective Functionalization of Carbohydrates by Synthetic Host Molecules ». Kyoto University, 2000. http://hdl.handle.net/2433/157078.

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本文データは平成22年度国立国会図書館の学位論文(博士)のデジタル化実施により作成された画像ファイルを基にpdf変換したものである
Kyoto University (京都大学)
0048
新制・課程博士
博士(工学)
甲第8342号
工博第1907号
新制||工||1168(附属図書館)
UT51-2000-F246
京都大学大学院工学研究科合成・生物化学専攻
(主査)教授吉田潤一, 教授北川進, 教授森島績
学位規則第4条第1項該当

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Ourri, Benjamin. « Complex molecular architectures for the recognition of therapeutic bio(macro)molecules ». Thesis, Lyon, 2020. http://www.theses.fr/2020LYSE1001/document.

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La reconnaissance de biomolécules dans des milieux biologiques complexes est un réel défi pour les chimistes et les biologistes, associé à des enjeux médicaux majeurs. Face à cette problématique, le chimiste peut choisir d’utiliser des molécules désignées par ses soins, ou encore de sélectionner et d’utiliser directement des structures commerciales ou naturelles. Suivant cette dernière approche, les dendrigrafts de lysines (DGL) ont montré une neutralisation des héparines de différentes tailles supérieures à l’action de la protamine, le seul médicament autorisé en cas de surdosage de l’anticoagulant. Une étude par dynamique moléculaire a permis de mettre en avant le mécanisme d’interaction entre les héparines d’une part, et les DGLs et la protamine d’autre part. Par ailleurs, suivant la première approche de design et synthèse, nous avons utilisé la chimie combinatoire dynamique pour obtenir des nouveaux récepteurs synthétiques à partir de brique moléculaires diverses de type 1,4-dithiphénols. Des études à la fois théorique, en DFT et dynamique moléculaire, et expérimentale, ont été menés pour comprendre les phénomènes régissant l’auto-assemblage de ces briques en oligomères cycliques et la complexation de ces cavitands avec des biomolécules d’intérêt
The recognition of biomolecules in complex biological media is a challenge associated with various therapeutic applications. The chemist can address this issue following two approaches: either he designs him-self and synthesises its molecules or he selects a commercially available or natural molecule and directly uses it for its properties. Following the last strategy, dendrigraft of lysine (DGL) efficiently neutralised all classes of the anticoagulant heparin, with a superior effect compared to protamine, the only FDA-approved drug in case of heparin overdosage. A study by molecular dynamic revealed the mechanism of binding between heparins and DGL and protamine respectively. At the opposite of this approach, we used dynamic combinatorial chemistry in order to obtain disulfide bridged cyclophanes from the self-assembly of various 1,4-bisthiophenols by oxidation of thiols into disulfide bonds. By a combination of theoretical (DFT and molecular dynamic) and experimental studies, we investigated the driving forces and the influences of fundamental concepts such as solvation and steric effects for the self-assembly of these polythiols and the binding of the corresponding cavitands with therapeutic biomolecules

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Orro, Graña Adolfo. « Examination of the role of binding site water molecules in molecular recognition ». Thesis, SciLifeLab Stockholm, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-200164.

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A set of algorithms were designed, implemented and evaluated in order to, first, identifyclusters of conserved waters in binding pockets, i.e. hydration sites. Then, their contributionto the free energy of binding in a ligand-protein association was quantified by calculatingtheir enthalpy and entropy. The information obtained by using these algorithms couldcontribute to the development of new drugs by generating new ligands that target specifichigh-energy, unfavorable waters. Evaluation tests show that our algorithms can indeedprovide relevant data about how hydration sites influence ligand-protein binding.

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Dourado, Eduardo Manuel de Azevedo. « Computer simulations of adsorption and molecular recognition phenomena in molecularly imprinted polymers ». Thesis, University of Edinburgh, 2011. http://hdl.handle.net/1842/5680.

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Molecularly imprinted polymers (MIPs) are a novel, promising family of porous materials with potential applications ranging from separations, chemical sensing and catalysis to drug delivery and artificial immunoassays. The unique feature of these materials is their biomimetic molecular recognition functionality. Molecular recognition is the biological phenomenon of specific, selective and strong association between a substrate and a ligand. In man made MIPs this functionality is implemented via templated synthesis protocol. MIPs are synthesized in the presence of additional template molecules which form complexes with functional monomers in the pre‐polymerization mixture. After polymerization, the template is removed, leaving cavities in the structure which are complementary in shape and interaction patterns to the template molecules. These cavities act as mimics of biological receptors and are able to recognize and rebind template molecules. Although the imprinting concept is simple in principle, synthesis of MIPs with precisely controlled characteristics and performance remains a challenging task. Composition, polymerization conditions, template removal process and application conditions all affect the properties of MIPs. The material is affected at different scales, but crucially at the microscopic level, the number, fidelity and accessibility of binding sites are dependent on all the factors mentioned. The full potential of these materials can only be achieved if researchers can control and optimize the properties of MIPs through detailed understanding of adsorption and molecular recognition processes in these materials. The objective of this work is to, using computer simulations and statistical mechanics; develop a fundamental description of MIP formation and function, and to link morphological features of the model materials to their molecular recognition capabilities. In general, molecular simulations employed in this study should allow easier and more efficient exploration of a vast number of factors influencing the behaviour of MIPs. At the heart of the approach developed in this thesis is a computational strategy that imitates all the stages of MIP formation and function. First, the model simulates the pre‐polymerization mixture, allowing the formation of template‐functional monomer complexes. (This stage is implemented via canonical Monte Carlo simulation). Complexes can have different structures, depending on the chemical nature of template and functional monomer; therefore complexes can have a range of association constants. The distribution of template‐functional monomer complexes also translates into a distribution of binding sites of different specificity after template removal. In the second stage of the process, adsorption simulations (grand canonical Monte Carlo) are performed for a variety of model MIPs prepared to assess the role of various processing conditions such as composition, density and binding sites degeneration. This strategy was first applied to a simplified description of MIP species in order to identify the minimal model capable of molecular recognition and thus shed the light on the very nature of this phenomenon. In the developed model, the molecular species are constructed from hard spheres, featuring small interaction sites on their surfaces. The bond between two interaction sites has the strength and topological features of a typical hydrogen bond. The model exhibits molecular recognition, being able to preferentially adsorb template molecules. The associations between template and functional monomers were analyzed and classified to describe the distribution of binding sites and their heterogeneity. Using this model, several experimental trends typically observed in MIP studies could be explained, such as maximum in the selectivity as a function of monomer concentration. Using this model, we were also able to explore hypothetical, alternative protocols for MIP synthesis in order to improve their performance. These include the use of alternative templates and the post‐synthetic surface modifications of MIPs. The general strategy to modelling MIP, employed in this thesis, was then applied to a more detailed description of MIPs with realistic force field potentials for all the species involved. This more elaborate model is simulated with a combination of molecular dynamics (MD) and Monte Carlo techniques. This detailed model provided a wealth of information on various types of complexes observed in the pre‐polymerization mixture. Specifically, it revealed the relative weight of different interactions in the complex and their role in the binding energy of adsorbates. These simulations also provided the comparison of the relative contribution of different types of interactions (van der Waals, Coulombic) involved in a molecular recognition process. We believe the insights gained in this work will contribute to the development of rational MIP design strategies. In the discussion of the results of the thesis we speculate on how these models can be further developed in order to generate quantitative predictions and what type of systems it would be interesting and important to investigate in the future.

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Rajbanshi, Arbin. « Supramolecular interactions from small-molecule selectivity to molecular capsules ». Diss., Manhattan, Kan. : Kansas State University, 2010. http://hdl.handle.net/2097/3879.

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Brown, Susan Elizabeth. « Molecular recognition by cyclodextrins / ». Title page, contents and abstract only, 1994. http://web4.library.adelaide.edu.au/theses/09PH/09phb8798.pdf.

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Westwell, Martin Stuart. « Cooperativity in molecular recognition ». Thesis, University of Cambridge, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.388343.

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Livres sur le sujet "Molecular recognitions"

Jean-Paul, Behr, dir. The lock-and-key principle : The state of the art--100 years on. Chichester [England] : Wiley, 1994.

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M, Roberts Stanley, et Royal Society of Chemistry (Great Britain). Fine Chemicals and Medicinals Group., dir. Molecular recognition, chemical and biochemical problems II. Cambridge : Royal Society of Chemistry, 1992.

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Van Binst, Georges, dir. Design and Synthesis of Organic Molecules Based on Molecular Recognition. Berlin, Heidelberg : Springer Berlin Heidelberg, 1986. http://dx.doi.org/10.1007/978-3-642-70926-5.

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1934-, Binst Georges van, dir. Design and synthesis of organic molecules based on molecular recognition. Berlin : Springer-Verlag, 1986.

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Buckingham, A. D., A. C. Legon et S. M. Roberts, dir. Principles of Molecular Recognition. Dordrecht : Springer Netherlands, 1993. http://dx.doi.org/10.1007/978-94-011-2168-2.

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Coleman, A. W., dir. Molecular Recognition and Inclusion. Dordrecht : Springer Netherlands, 1998. http://dx.doi.org/10.1007/978-94-011-5288-4.

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Rotello, Vincent M., et S. Thayumanavan, dir. Molecular Recognition and Polymers. Hoboken, NJ, USA : John Wiley & Sons, Inc., 2008. http://dx.doi.org/10.1002/9780470384053.

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D, Buckingham A., Legon A. C et Roberts Stanley M, dir. Principles of molecular recognition. London : Blackie Academic & Professional, 1993.

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Weber, E., dir. Molecular Inclusion and Molecular Recognition — Clathrates II. Berlin, Heidelberg : Springer Berlin Heidelberg, 1988. http://dx.doi.org/10.1007/3-540-19338-3.

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Weber, E., dir. Molecular Inclusion and Molecular Recognition — Clathrates I. Berlin/Heidelberg : Springer-Verlag, 1987. http://dx.doi.org/10.1007/bfb0003833.

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Chapitres de livres sur le sujet "Molecular recognitions"

Legon, A. C., et D. J. Millen. « Molecular recognition involving small gas-phase molecules ». Dans Principles of Molecular Recognition, 17–42. Dordrecht : Springer Netherlands, 1993. http://dx.doi.org/10.1007/978-94-011-2168-2_2.

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Shinkai, Seiji. « Molecular Design of Calixarene-Based Host Molecules ». Dans Inclusion Phenomena and Molecular Recognition, 125–33. Boston, MA : Springer US, 1990. http://dx.doi.org/10.1007/978-1-4613-0603-0_13.

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Cleaves, Henderson James. « Molecular Recognition ». Dans Encyclopedia of Astrobiology, 1079–80. Berlin, Heidelberg : Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-11274-4_1019.

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Cleaves, Henderson James. « Molecular Recognition ». Dans Encyclopedia of Astrobiology, 1613. Berlin, Heidelberg : Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-662-44185-5_1019.

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Donato, Laura. « Molecular Recognition ». Dans Encyclopedia of Membranes, 1–2. Berlin, Heidelberg : Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-642-40872-4_1613-1.

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Cleaves, Henderson James. « Molecular Recognition ». Dans Encyclopedia of Astrobiology, 1. Berlin, Heidelberg : Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-642-27833-4_1019-3.

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Cleaves, Henderson James. « Molecular Recognition ». Dans Encyclopedia of Astrobiology, 1. Berlin, Heidelberg : Springer Berlin Heidelberg, 2022. http://dx.doi.org/10.1007/978-3-642-27833-4_1019-4.

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Lehn, J. M. « Molecular Recognition : Design of Abiotic Receptor Molecules ». Dans Design and Synthesis of Organic Molecules Based on Molecular Recognition, 173–84. Berlin, Heidelberg : Springer Berlin Heidelberg, 1986. http://dx.doi.org/10.1007/978-3-642-70926-5_14.

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Shinkai, Seiji. « Molecular Recognition of Calixarene-Based Host Molecules ». Dans United States-Japan Seminar on Host-Guest Chemistry, 193–201. Dordrecht : Springer Netherlands, 1989. http://dx.doi.org/10.1007/978-94-009-0969-4_22.

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Kitaura, Kazuo. « Molecular Recognition and Self-Regulation ». Dans From Molecules to Molecular Systems, 95–109. Tokyo : Springer Japan, 1998. http://dx.doi.org/10.1007/978-4-431-66868-8_6.

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Actes de conférences sur le sujet "Molecular recognitions"

Higgins, M. J., M. Polcik, T. Fukuma, J. E. Sader et S. P. Jarvis. « Direct Mechanical Measurement of Organised Water and the Influence of Adjacent Surface Chemistry Using Atomic Force Microscopy (Keynote) ». Dans World Tribology Congress III. ASMEDC, 2005. http://dx.doi.org/10.1115/wtc2005-64383.

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Directly measuring structural changes in water with a mechanical probe of lateral dimensions comparable to that of a single molecule provides an invaluable insight into how and why bio-molecules behave with high selectivity or why certain surfaces promote or inhibit bio-molecular adhesion. In the immediate vicinity of the molecule, continuum models break down and the aqueous environment will often form a discrete layered structure depending on the nature of the molecule. The absence or presence of such structure may be fundamental in influencing the promotion or inhibition of protein adsorption, biological function and membrane recognition.

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Vitale, U., A. Rechichi, M. D’Alonzo, C. Cristallini, N. Barbani, G. Ciardelli et P. Giusti. « Selective Peptide Recognition With Molecularly Imprinted Polymers in Designing New Biomedical Devices ». Dans ASME 8th Biennial Conference on Engineering Systems Design and Analysis. ASMEDC, 2006. http://dx.doi.org/10.1115/esda2006-95587.

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Molecular imprinting is a technique for the synthesis of polymers capable to bind selectively specific molecules. The imprinting of large proteins, like cell adhesion proteins or cell receptors, can lead to important and innovative biomedical applications. However such molecules show such important conformational changes in the polymerisation environment that the recognition sites are poorly specific. The “epitope approach” can overcome this limit by adopting, as template, a stable short peptide sequence representative of an accessible fragment of a larger protein. The resulting imprinted polymer can recognize both the template and the whole molecule thanks to the specific cavities for the epitope. In this work two molecularly imprinted polymer formulations (macroporous monolith and nanospheres) were obtained with the protected peptides Z-Thr-Ala-Ala-OMe, as template, and Z-Thr-Ile-Leu-OMe, as analogue for the selectivity evaluation, the methacrylic acid, as functional monomer, the trimethylolpropane trimethacrylate and pentaerythritol triacrylate, as cross-linkers. Polymers were synthesized by precipitation polymerisation in acetonitrile at 60 °C, thermally initiated with azobisisobutyronitrile. All polymers were characterized by the standard techniques SEM, FT-IR, and TGA. The supernatants from the polymerisation and the rebinding solutions were analysed by HPLC. The higher cross-linked polymers retained about the 70% of the template, against about the 20% for the lower ones. The extracted template amount and the rebinding capacity decreased with the cross-linking degree, while the selectivity showed the opposite behaviour. The pentaerythritol triacrylate cross-linked polymers showed the best recognition (MIP 2−, α = 1.71) and selectivity (MIP 2+, α′ = 5.58) capabilities.

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Chen, Zhen-He, Ai-Qin Luo et Li-Quan Sun. « Studies on molecular recognition of thymidines with molecularly imprinted polymers ». Dans Second International Conference on Smart Materials and Nanotechnology in Engineering, sous la direction de Jinsong Leng, Anand K. Asundi et Wolfgang Ecke. SPIE, 2009. http://dx.doi.org/10.1117/12.847732.

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Ciardelli, G., F. M. Montevecchi, P. Giusti, D. Silvestri, I. Morelli, C. Cristallini et G. Vozzi. « Molecular Imprinted Nanostructures in Biomedical Applications ». Dans ASME 8th Biennial Conference on Engineering Systems Design and Analysis. ASMEDC, 2006. http://dx.doi.org/10.1115/esda2006-95669.

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Molecular imprinting is an emerging technology that allows to introduce nanostructured cavities into a polymer. In preparing molecular imprinted polymers (MIPs), the functional monomer(s) is first prearranged around the template molecule by specific interactions; the polymerisation is then carried out with a high percentage of cross-linking agent (which “freezes” the macromolecular network). Molecular mechanics and dynamics can be used to gain indications on the best monomers to be used in order to maximize interactions with the template. Once the polymerization reaction has been completed, the template is removed from the rigid three-dimensional network, leaving free recognition cavities available for the successive selective rebinding of the template itself. Precipitation polymerisation in dilute solutions involves the spontaneous formation of submicron scale polymer particles, which result suitable for recognition-rebinding application. Therapeutic applications: The recognition mechanism by MIPs relies mainly on the establishment of reversible hydrogen bonding interactions. It is clear that the efficiency of this mechanism is endangered in aqueous environments. MIPs working in water solutions are clearly of great interest in the medical and food industry and in sensor applications. We recently overcame these difficulties by the realisation of a system where cross-linked MI methylmethacrylate-methacrylic acid nanospheres where loaded on the surface or inside the matrix of porous membranes created by phase inversion. E.g. membranes were modified by adding cholesterol imprinted nanoparticles. Rebinding performances of nanoparticles modified membranes in buffer solution were tested showing a specific recognition of 14.09 mg of cholesterol/g of system (membrane and nanoparticles), indicating maintained binding capacity of supported particles as well. Tissue engineering: The engineering of functionalised polymeric structures for the study of cell activity is essential to the development of biological substitutes containing vital cells capable of regenerating or enhancing tissue function. Cells are organised within a complex matrix consisting of high molecular weight protein and polysaccharides known as the Extracellular Matrix (ECM). Two approaches are described to explore the possibility to provide scaffolds with specific and selective recognition of peptide sequences or proteins involved in cell adhesion mechanisms: one approach consists in the modification of porous structures with nanoparticles imprinted with aminoacid sequences (epitopes) of ECM proteins or transmembrane integrins, while the other consists in the combination of Soft Litography and Molecular Imprinting technologies (SOFT-MI). This technology allows to create imprinting nanocavities selective towards ECM proteins in microfabricated scaffolds, and in particular it permits to realise patterns with a well defined microscale geometry in polymethylmethacrylate (PMMA) scaffolds providing them with cell adhesion properties that were missing in the non-imprinted scaffold.

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Kiesser, Birgit, Dirk Nopper, Martin Herold, Guenter Gauglitz, Martin Elbs, Stefan Groeschel, Roland Brock et Guenter Jung. « Cyclopeptide derivatives for molecular recognition ». Dans Environmental and Industrial Sensing, sous la direction de Tuan Vo-Dinh et Stephanus Buettgenbach. SPIE, 2001. http://dx.doi.org/10.1117/12.417434.

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Yu, Shuang, David A. Puleo et Ai-qin Luo. « Preliminary Study on Repeatability of Molecular Recognition Capability of a Silica-Based Molecularly Imprinted Polymer ». Dans 2010 4th International Conference on Bioinformatics and Biomedical Engineering (iCBBE). IEEE, 2010. http://dx.doi.org/10.1109/icbbe.2010.5516486.

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Neumann, Oara, Ryan Huschka, Aoune Barhoumi, Carly S. Levin, Janardan Kundu et N. J. Halas. « Nanoscale plasmonics for molecular recognition and light-triggered molecular release ». Dans 11th European Quantum Electronics Conference (CLEO/EQEC). IEEE, 2009. http://dx.doi.org/10.1109/cleoe-eqec.2009.5191712.

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Long, Timothy E., Casey L. Elkins, Lars Kilian, Taigyoo Park, Scott R. Trenor, Koji Yamauchi, Ralph H. Colby, Donald J. Leo et Brian J. Love. « “Reversible Macromolecules” as Scaffolds for Adaptive Structures ». Dans ASME 2003 International Mechanical Engineering Congress and Exposition. ASMEDC, 2003. http://dx.doi.org/10.1115/imece2003-43010.

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Self-healing macromolecular structures, submicron capsules and fibers with molecular recognition, stimuliresponsive molecules, solvent-free rheological reversibility, multivalency in rational drug design, and the emergence of new fields of adaptive and evolutive chemistry will require a predictive synergy of tailored non-covalent and covalent bonding in molecular design. Supramolecular chemistry has emerged as a stimulating focal point that will enable these scientific and technological discoveries, and biorecognition and biomolecular organization often serve as the inspiration for the future design of supramolecular assemblies. Linear and branched macromolecules are conventionally prepared using unique combinations of step-growth and chain polymerization strategies wherein the repeating units are irreversibly connected using stable covalent bonds. Moreover, optimum physical properties and commercial success of macromolecules are derived from our ability to prepare exceptionally high molecular weights in a controlled fashion. Although high molecular weight linear macromolecules are desirable for the optimization of physical performance and commercial impact, high molecular weights often compromise future solvent-free manufacturing, melt processability, thermal stability, and recyclability of the final products. Our recent efforts have demonstrated the utility of living anionic polymerization techniques to place functionality at desired positions on the polymer backbone. This control allowed investigation of the relationship between topology and tailored functionality, a fundamental investigation that may lead to interesting adaptive and smart applications. Specifically, the synthesis of polyisoprene homopolymers in a variety of topologies was performed, as well as the introduction of complementary hydrogen bonding to diverse families of hydroxyl containing polymeric and monomeric precursors.

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D'Silva, Claudius. « Molecular recognition : A route to the self-assembly of molecular circuitry ». Dans 1992 14th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE, 1992. http://dx.doi.org/10.1109/iembs.1992.5760921.

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D'Silva. « Molecular Recognition : A Route To The self-assembly of molecular Circuitry ». Dans Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE, 1992. http://dx.doi.org/10.1109/iembs.1992.589618.

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Rapports d'organisations sur le sujet "Molecular recognitions"

Atassi, Zouhair M. Molecular Recognition of Alpha-Neurotoxins. Fort Belvoir, VA : Defense Technical Information Center, novembre 1990. http://dx.doi.org/10.21236/ada230342.

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Wasielewski, M. R., K. Raymond et D. E. Walt. Ion and molecule sensors using molecular recognition in luminescent, conductive polymers. 1998 annual progress report. Office of Scientific and Technical Information (OSTI), juin 1998. http://dx.doi.org/10.2172/13447.

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Tiede, D. M., A. C. Vashista et M. R. Gunner. Electrostatic basis for molecular recognition in photosynthesis. Office of Scientific and Technical Information (OSTI), novembre 1994. http://dx.doi.org/10.2172/10194615.

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Tan, Weihong. Ultrasensitive Biosensors for Molecular Recognition and Manipulation. Fort Belvoir, VA : Defense Technical Information Center, février 2003. http://dx.doi.org/10.21236/ada410625.

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Wasielewski, Michael R. SENSORS USING MOLECULAR RECOGNITION IN LUMINESCENT, CONDUCTIVE POLYMERS. Office of Scientific and Technical Information (OSTI), septembre 1999. http://dx.doi.org/10.2172/828084.

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Wasielewski, M. R. Ion and molecule sensors using molecular recognition in luminescent, conductive polymers. FY 1997 year-end progress report. Office of Scientific and Technical Information (OSTI), janvier 1997. http://dx.doi.org/10.2172/13446.

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Edwards, David. Molecular Recognition of Endocytic Codes in Receptor Tyrosine Kinases. Fort Belvoir, VA : Defense Technical Information Center, juin 1999. http://dx.doi.org/10.21236/ada375148.

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Braun, W. A. Molecular Recognition of DNA Damage Sites by Apurinic/Apyrimidinic Endonucleases. Office of Scientific and Technical Information (OSTI), juillet 2005. http://dx.doi.org/10.2172/877152.

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Allara, David L. Characterization of the Molecular Basis of Cell Recognition at Surfaces. Fort Belvoir, VA : Defense Technical Information Center, décembre 1998. http://dx.doi.org/10.21236/ada384249.

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Jia, S., T. M. Nenoff, P. Provencio, Y. Qiu, J. A. Shelnutt, S. G. Thoma et J. Zhang. Design Molecular Recognition Materials for Chiral Sensors, Separtations and Catalytic Materials. Office of Scientific and Technical Information (OSTI), novembre 1998. http://dx.doi.org/10.2172/2055.

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