Littérature scientifique sur le sujet « Mitochondrial targeting sequence »
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Articles de revues sur le sujet "Mitochondrial targeting sequence"
LEISSRING, Malcolm A., Wesley FARRIS, Xining WU, Danos C. CHRISTODOULOU, Marcia C. HAIGIS, Leonard GUARENTE et Dennis J. SELKOE. « Alternative translation initiation generates a novel isoform of insulin-degrading enzyme targeted to mitochondria ». Biochemical Journal 383, no 3 (26 octobre 2004) : 439–46. http://dx.doi.org/10.1042/bj20041081.
Texte intégralFaria, Rúben, Eric Vivés, Prisca Boisguerin, Angela Sousa et Diana Costa. « Development of Peptide-Based Nanoparticles for Mitochondrial Plasmid DNA Delivery ». Polymers 13, no 11 (1 juin 2021) : 1836. http://dx.doi.org/10.3390/polym13111836.
Texte intégralBaysal, Can, Ana Pérez-González, Álvaro Eseverri, Xi Jiang, Vicente Medina, Elena Caro, Luis Rubio, Paul Christou et Changfu Zhu. « Recognition motifs rather than phylogenetic origin influence the ability of targeting peptides to import nuclear-encoded recombinant proteins into rice mitochondria ». Transgenic Research 29, no 1 (10 octobre 2019) : 37–52. http://dx.doi.org/10.1007/s11248-019-00176-9.
Texte intégralKaufmann, Thomas, Sarah Schlipf, Javier Sanz, Karin Neubert, Reuven Stein et Christoph Borner. « Characterization of the signal that directs Bcl-xL, but not Bcl-2, to the mitochondrial outer membrane ». Journal of Cell Biology 160, no 1 (6 janvier 2003) : 53–64. http://dx.doi.org/10.1083/jcb.200210084.
Texte intégralTakada, Y., N. Kaneko, H. Esumi, P. E. Purdue et C. J. Danpure. « Human peroxisomal l-alanine : glyoxylate aminotransferase. Evolutionary loss of a mitochondrial targeting signal by point mutation of the initiation codon ». Biochemical Journal 268, no 2 (1 juin 1990) : 517–20. http://dx.doi.org/10.1042/bj2680517.
Texte intégralMajumdar, Ramanath, et William A. Bridger. « Mitochondrial translocation and processing of the precursor to the α-subunit of rat liver succinyl-CoA synthetase ». Biochemistry and Cell Biology 68, no 1 (1 janvier 1990) : 292–99. http://dx.doi.org/10.1139/o90-040.
Texte intégralMiyazaki, Emi, Yuichiro Kida, Katsuyoshi Mihara et Masao Sakaguchi. « Switching the Sorting Mode of Membrane Proteins from Cotranslational Endoplasmic Reticulum Targeting to Posttranslational Mitochondrial Import ». Molecular Biology of the Cell 16, no 4 (avril 2005) : 1788–99. http://dx.doi.org/10.1091/mbc.e04-08-0707.
Texte intégralRomesberg, Amy, et Bennett Van Houten. « Targeting Mitochondrial Function with Chemoptogenetics ». Biomedicines 10, no 10 (1 octobre 2022) : 2459. http://dx.doi.org/10.3390/biomedicines10102459.
Texte intégralChang, Yu-Jung, Kuan-Wei Chen et Linyi Chen. « Mitochondrial ROS1 Increases Mitochondrial Fission and Respiration in Oral Squamous Cancer Carcinoma ». Cancers 12, no 10 (1 octobre 2020) : 2845. http://dx.doi.org/10.3390/cancers12102845.
Texte intégralSantos, Herbert J., Yoko Chiba, Takashi Makiuchi, Saki Arakawa, Yoshitaka Murakami, Kentaro Tomii, Kenichiro Imai et Tomoyoshi Nozaki. « Import of Entamoeba histolytica Mitosomal ATP Sulfurylase Relies on Internal Targeting Sequences ». Microorganisms 8, no 8 (12 août 2020) : 1229. http://dx.doi.org/10.3390/microorganisms8081229.
Texte intégralThèses sur le sujet "Mitochondrial targeting sequence"
Nashed, Salomé. « Étude fonctionnelle et évolutive du résidu situé en position 2 des protéines ». Electronic Thesis or Diss., Sorbonne université, 2023. http://www.theses.fr/2023SORUS219.
Texte intégralThe residue located at position 2 of proteins, following their initiator methionine, is a key signal for the co-translational recruitment of various modification enzymes that early impact their cellular fate (addressing, folding, half-life). Although the importance of this residue is established for a few proteins, its role at the global scale of the proteome and the nature of the selective pressures it may be subject to remain unexplored to this day. During my thesis, I used for the first time global analysis methodologies to conduct a functional and evolutionary study of the residue located at position 2 of proteins. I used two complementary in silico approaches developed in the model yeast Saccharomyces cerevisiae. The first approach I used is the study of modification enzymes whose recruitment depends on the residue at position 2 of their targets. I focused in particular on N-acetyltransferases. These enzymes have the same enzymatic activity of N-acetylation but target distinct subsets of proteins, and their deletions are associated with different phenotypes, raising the question of the specific role of each enzyme in cellular physiology. Through the analysis of experimental data related to these enzymes, I characterized their global selectivity in vivo and formally demonstrated that they indeed have differential physiological roles. The second approach I used is the study of the distribution of amino acids at position 2 in the proteome and in functional groups of proteins defined by the Gene Ontology. While current tools used to perform Gene Ontology analyses do not take into account the hierarchical structure of this resource, I developed an algorithm to synthesize and visualize the results obtained by such analyses to facilitate their interpretation. This approach allowed the identification of groups of proteins that present a distinct amino acid usage at position 2 compared to that observed in the proteome at this position. These two global analysis methods converged toward the same result, namely that mitochondrial precursors possessing an N-terminal addressing sequence (MTS for mitochondrial targeting sequence) exhibit at position 2 an overrepresentation of large hydrophobic residues, critical for their import into mitochondria and enabling their recognition by the NatC acetyltransferase. The amino acid bias at position 2 of MTS is highly conserved in the Saccharomycotina lineage and has partially evolved in humans and the plant Arabidopsis thaliana. I also highlighted the existence of several categories of MTS depending on the nature of the residue they carry at position 2, which may indicate co-evolution of position 2 of MTS and their overall composition and raises the question of optimal properties of these sequences. Finally, I showed that yeast signal peptides and the chloroplast N-terminal addressing sequence in Arabidopsis thaliana also exhibit amino acid biases at position 2, suggesting that the residue at this position could play a key role in the recognition of these sequences by associated addressing and import systems
El, Barbry Houssam. « Découverte du rôle crucial du résidu en position 2 des séquences MTS d’adressage mitochondrial ». Electronic Thesis or Diss., Sorbonne université, 2023. http://www.theses.fr/2023SORUS035.
Texte intégralMitochondria are complex organelles involving a thousand proteins, most of which are encoded in the nuclear genome. Their biogenesis has required the evolutionary development of efficient protein addressing and import systems, and failures of these systems are associated with serious pathologies, neuropathies, cardiovascular disorders, myopathies, neurodegenerative diseases and cancers.Many mitochondrial proteins have an N-terminal addressing sequence called MTS (Mitochondrial Targeting Sequence) which forms an amphiphilic alpha helix essential for their mitochondrial import. However, the sequence of the various MTSs is highly variable and their critical characteristics are not yet well understood. The starting point of my thesis was the discovery in yeast of an overrepresentation of 4 hydrophobic amino acids (F, L, I, W) at position 2 of the MTSs sequences. During my thesis, I was able to confirm the critical role of the nature of the residue in position 2 of the MTSs through directed mutagenesis experiments. Indeed, thanks to the development of an innovative system for screening import defects based on the functional rescue of the toxicity of a mitochondrial protein, I was able to observe that only residues overrepresented at position 2 of mitochondrial proteins allowed efficient import. My work has thus demonstrated the existence of strong evolutionary constraints at position 2 of MTSs, the understanding of which could ultimately be useful for optimising the mitochondrial addressing of therapeutic proteins in patients suffering from mitochondrial diseases
Chang, Juan-Yu, et 張絹鈺. « The functional study of mitochondrial NADH dehydrogenase (ubiquinone) Fe-S protein 8 and characterization of its mitochondrial targeting sequence ». Thesis, 2010. http://ndltd.ncl.edu.tw/handle/65826221666303294182.
Texte intégral國立清華大學
分子醫學研究所
98
Oxidative phosphorylation system in mammalian cells contains five enzyme complexes. Among them, mitochondrial complex I is the biggest and the most complicated, with many undefined subunits and has no resolved complete structure. Mammalian mitochondrial complex I comprises of forty-five subunits, and seven of them are encoded by the mitochondrial genome. The remaining subunits are encoded by the nuclear genome and imported into mitochondria to perform their functions. NADH dehydrogenase (ubiquinone) Fe-S protein 8 (NDUFS8) is one of the nuclear-encoded mitochondrial core proteins of complex I. It contains two tetranuclear iron-sulfur clusters and plays an important role in electron transport. Mutations on NDUFS8 have been found to cause Leigh syndrome with mitochondrial complex I deficiency. In this study, RNA interference technique was used to knock down the NDUFS8 expression in T-REx293 cells to investigate the function of NDUFS8. Experimental results demonstrated that reducing expression of NDUFS8 would retard the cellular growth rate, slow down the oxygen consumption efficiency and increase the production of reactive oxygen species (ROS). Using high resolution clear native gel electrophoresis (HrCNE) for investigating the integrity of mitochondrial complex I revealed that knockdown of NDUFS8 would not affect the assembly of mitochondrial complex I but reduce its NADH oxidation activities. Restoration of NDUFS8 in a suppressed cell line improved the ability of oxygen consumption and NADH oxidation of complex I. In addition, various deletion and fusion constructs of NDUFS8 were generated to characterize the mitochondrial targeting sequence of this protein. The results revealed that the N-terminal fragment of 18 residues possessed the ability to import EGFP into mitochondria, which is shorter than the prediction of 34 amino acid residues proposed by MitoprotII program. Interestingly, there was also an unexpected result that all of the N-terminal deletion constructs of NDUFS8 protein were located in a specific region of nuclei. It was speculated that there is a nuclear localization signal hiding in NDUFS8 sequence. This study demonstrated that NDUFS8 play an essential role in complex I activity, and the mitochondrial targeting sequence of NDUFS8 existing or not will determine the subcellular localization in mitochondria or in nuclei.
Chapitres de livres sur le sujet "Mitochondrial targeting sequence"
Naylor, D. J., N. J. Hoogenraad et P. B. Hoj. « Mammalian mitochondrial GrpE ». Dans Guidebook to Molecular Chaperones and Protein-Folding Catalysts, 142–44. Oxford University PressOxford, 1997. http://dx.doi.org/10.1093/oso/9780198599494.003.0056.
Texte intégralBlecher, O., et A. Breiman. « Plant FKBP73 ». Dans Guidebook to Molecular Chaperones and Protein-Folding Catalysts, 417–18. Oxford University PressOxford, 1997. http://dx.doi.org/10.1093/oso/9780198599494.003.00163.
Texte intégralWienhues, Ulla, Hans Koll, Karin Becker, Bernard Guiard et Franz-Ulrich Hartl. « Protein targeting to mitochondria ». Dans Protein Targeting, 135–59. Oxford University PressOxford, 1992. http://dx.doi.org/10.1093/oso/9780199632060.003.0006.
Texte intégralMcColl, D., et F. U. Hartl. « Ribosome-associated chaperones and protein synthesis : molecular machines catalysing protein targeting, folding and assembly ». Dans Guidebook to Molecular Chaperones and Protein-Folding Catalysts, 489–98. Oxford University PressOxford, 1997. http://dx.doi.org/10.1093/oso/9780198599494.003.00189.
Texte intégralHoj, P. B., N. J. Hoogenraad et D. Hartman. « Mammalian Cpn60 ». Dans Guidebook to Molecular Chaperones and Protein-Folding Catalysts, 197–98. Oxford University PressOxford, 1997. http://dx.doi.org/10.1093/oso/9780198599494.003.0074.
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