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1
Preisser, Richard Herman III. « Food Safe Alternatives to Methyl Bromide in Country Ham Production ». Thesis, Virginia Tech, 2016. http://hdl.handle.net/10919/73654.
Texte intégralRésumé :
Dry cured meat production is a costly and long term investment for producers. Ham mites (Tyrophagus putrescentiae) are a common pest of dry cured products and cause devastating effects, potentially nullifying producers' investments due to loss of salable product, as well as regulatory concerns. Methyl bromide, a chemical fumigant used to control mite populations, is damaging to stratospheric ozone and will no longer be available. Presently, no alternative control measure has been approved to combat the ham mite; therefore, it is essential to identify potential alternatives. Interest in safe alternatives to control arthropod pest populations is gaining momentum, and garlic (Allium sativum) has been used to control other arthropod species including the northern fowl mite, mosquitos, and aphids. We chose to explore the efficacy of garlic juice in controlling T. putrescentiae. Using a choice test design, approximately 65% of the inoculated mites colonized on the control ham cubes, while no mites remained on garlic juice-dipped cubes. Garlic was ineffective when examined for volatile efficacy, but was effective in direct contact assays. However, as garlic juice was aged and diluted, efficacy was reduced even after treatments with antioxidants, metal chelators, and pH neutralization. In total, garlic juice acted as a short term repellent and showed efficacy in contact models, but application is time sensitive due to variable enzymatic degradation.Master of Science
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Barbosa, Marina Ferraz de Camargo. « Free living astigmatid mites (Astigmatina) : new taxa, rearing and use for mesostigmatid (Mesostigmata) predatory mite production ». Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/11/11146/tde-05072016-110109/.
Texte intégralRésumé :
The cohort Astigmatina is divided in two major groups: Psoroptidia, composed mainly by feather and fur mites, and Non-psoroptidia, a dominant component of the acarofauna in ephemeral habitats. In these environments Astigmatina usually are saprophages or feed on fungi or bacteria. Astigmatina protonymphs undergo a complete reorganization of the body structure leading to the production of heteromorphic deutonymphs, generally specialized for dispersion through phoresy using arthropods and vertebrates as phoronts. Although most Astigmatina occur in natural environments, some species live in anthropic environments, such as food deposits, where some of them became pests; some Astigmatina infest subterraneous plant organs. Despite their economic and ecological importance, studies on the diversity and taxonomy of Astigmatina in Brazil have been rare over the last decades. The general objective of this thesis was to collaborate to the knowledge of the diversity and to evaluate the potential practical uses of these mites in Brazil. For this, new genera and species were described, method for rearing dust mites was studied and the efficiency of Astigmatina as prey for edaphic predators was evaluated. A new species of Thyreophagus (Astigmatina: Acaridae) was described based on specimens collected in Brazil, the association of three other species of this genus with stored food was reviewed and a key to all species of this genus was prepared. The genus Neotropacarus (Astigmatina: Acaridae), commonly found on plant leaves, was reviewed with the redescription of two species and description of new species collected in Brazil and from the Philippines. Two new genera and seven new species of Acaridae associated with the bee family Apidae was described and a key to Acaridae genera in subfamily Horstiinae was prepared. Several species of Astigmatina were evaluated as prey for predatory mites Stratiolaelaps scimitus (Womersley) (Mesostigmata: Laelapidae) and Protogamasellopsis zaheri Abo-Shnaf, Castilho and Moraes (Mesostigmata: Rhodacaridae), which oviposited on all evaluated astigmatids, with Tyrophagus putrescentiae (Schrank) and Aleuroglyphus ovatus (Tropeau) (Acaridae) being the most suitable prey. Seven foods and two development period, 30 and 60 days, after the introduction of 400 females of two important dust mite species, Blomia tropicalis van Bronswijk, de Cock e Oshima and Dermatophagoides pteronyssinus (Trouessart) were evaluate. With the most suitable foods, the population growth were higher than 20.2 and 15.3 for B. tropicalis and D. pteronyssinus, respectively.A coorte Astigmatina é dividida em dois grandes grupos: Psoroptidia, composto majoritariamente por ácaros de pena e pelos, e Não-Psoroptidia, componente dominante da acarofauna de habitats efêmeros. Nestes ambientes, os Astigmatina geralmente são saprófagos ou se alimentam de fungos e bactérias. Protoninfas de Astigmatina passam por uma completa reorganização da estrutura corporal levando à produção de deutoninfas heteromórficas geralmente especializadas para dispersão por forese utilizando artrópodes e vertebrados como forontes. Apesar de a maioria dos Astigmatina ocorrer em ambientes naturais, algumas espécies passaram a ocupar ambientes antrópicos, como depósitos de alimentos, onde algumas se tornaram pragas; alguns Astigmatina infestam órgãos subterrâneos de plantas. A despeito de sua importância econômica e ecológica, estudos sobre a diversidade e taxonomia dos Astigmatina no Brasil têm sido raros nas últimas décadas. O objetivo geral desta tese foi colaborar para o conhecimento da diversidade e avaliar o potencial de uso prático de espécies Astigmatina no Brasil. Para isso, novos gêneros e espécies foram descritos, métodos para criação de ácaros de poeira foram estudados e a eficiência de Astigmatina como presas para ácaros predadores edáficos foi avaliada. Uma nova espécie de Thyreophagus (Astigmatina: Acaridae) foi descrita com base em espécimes coletados no Brasil, uma revisão sobre três outras espécies deste gênero associadas com alimentos armazenados foi realizada e uma chave para todas as espécies deste gênero foi elaborada. O gênero Neotropacarus (Astigmatina: Acaridae), comumente associado a folhas de plantas, foi revisado, com redescrição de duas espécies e descrição de novas espécies coletadas no Brasil e nas Filipinas. Dois novos gêneros e sete novas espécies de Acaridae associados à família de abelha Apidae foram descritos e uma chave para os gêneros da subfamília Horstiinae foi elaborada. Diversas espécies de Astigmatina foram avaliadas como presas para os ácaros predadores Stratiolaelaps scimitus (Womersley) (Mesostigmata: Laelapidae) e Protogamasellopsis zaheri Abo-Shnaf, Castilho e Moraes (Mesostigmata: Rhodacaridae), que ovipositaram em todas os Astigmatina avaliados, sendo Tyrophagus putrescentiae (Schrank) e Aleuroglyphus ovatus (Tropeau) (Acaridae) as presas mais promissoras. Sete alimentos e dois períodos de desenvolvimento, 30 e 60 dias, após inoculação de 400 fêmeas de duas espécies importantes na poeira residencial, Blomia tropicalis van Bronswijk, de Cock e Oshima e Dermatophagoides pteronyssinus (Trouessart) foram avaliados. Com os alimentos mais adequados, o crescimento populacional nas colônias foram maiores que 20.2 e 15.3 para B. tropicalis e D. pteronyssinus, respectivamente.
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CARUSO, MATTEO FRANCESCO. « Ottimizzazione del processo produttivo degli acari della specie Dermatophagoides e dei loro allergeni ». Doctoral thesis, Università Cattolica del Sacro Cuore, 2020. http://hdl.handle.net/10280/72219.
Texte intégralRésumé :
Questa tesi è frutto della collaborazione tra l'Università e Lofarma S.p.A., un’azienda farmaceutica italiana leader nel settore che produce preparati per pazienti allergici come kit diagnostici e immunoterapie. A tale scopo nel reparto di Acarologia ogni anno vengono allevati e raccolti decine di chilogrammi di acari adulti e, dopo alcune manipolazioni, utilizzati nel reparto produttivo come materia prima per la maggior parte delle formulazioni. Lo scopo di questo progetto è analizzare l'attuale metodo di produzione e studiare se alcuni passaggi potrebbero essere ottimizzati per migliorare la resa, il tasso di produzione e la qualità della materia prima, cercando nel contempo di ridurre costi e tempi di lavorazione.
La ricerca è stata suddivisa in 2 aree principali: 1) Procedure di Allevamento (valutazione della qualità della dieta e del ceppo allevato) e 2) Manipolazioni della Materia Prima (ottimizzazione del processo di pulizia e valorizzazione della materia prima). Tra questi, i risultati più significativi sono stati raggiunti nella sezione Manipolazione delle Materie Prime, dove viene descritto un nuovo processo di rifinitura in grado di ottenere rese finali più elevate in tempistiche più brevi.
Dopo aver analizzato l'intero ciclo produttivo, è possibile concludere che, nel contesto del Reparto di Acarologia, è più conveniente procedere con una migliore manipolazione della materia prima piuttosto che modificare le attuali metodiche di allevamento, che sembrano già adatte per le esigenze di Lofarma.This thesis is based on collaboration between University and Lofarma S.p.A., a leading Italian pharmaceutical company which produce preparation for allergic patients like diagnostic kits and immunotherapies. To this purpose every year dozens of kilograms of adult mites are reared and collected in the Acarology department and, after manipulations, used in the Production Department as raw material for most of the preparation. The aim of this project is to analyze the current production methodology of Acarology department and investigate if some steps could be optimized to improve the yield, the production rate and the quality of the raw material while trying to reduce costs and processing times. The research has been divided in 2 main areas: 1) Rearing Procedures (quality assessment about the diet and the strain enacted) and 2) Raw Material Manipulations (optimization of the refining process and valorization of the Raw Material). Between those, most significant results have been achieved in the Raw Material Manipulation section, where is described a novel refining process capable of obtaining higher final yields in a shorter working time. After analyzing the whole manufacturing cycle, is possible to conclude that, within the context of the Acarology Department, is more convenient to proceed with a better manipulation of the raw material in the refining process rather than modifying the actual rearing procedure, which is already suitable for Lofarma needs.
4
XAVIER, Maria Virgínia Alves. « Avaliação do potencial de extratos de plantas da caatinga no controle do ácaro-vermelho do pinhão manso ». Universidade Federal Rural de Pernambuco, 2014. http://www.tede2.ufrpe.br:8080/tede2/handle/tede2/6163.
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Maria Virginia Alves Xavier.pdf: 938724 bytes, checksum: 3969de87ac989fbf6102e3ade913c13d (MD5)Made available in DSpace on 2016-12-19T15:11:21Z (GMT). No. of bitstreams: 1 Maria Virginia Alves Xavier.pdf: 938724 bytes, checksum: 3969de87ac989fbf6102e3ade913c13d (MD5) Previous issue date: 2014-02-24
Biodiesel production has received enough encouragement and among the crops with potential applicability to this highlights the physic nut (Jatropha curcas L. ) , which has been identified as one of the most promising crops for biodiesel and inclusion in family production chain , which has opened up broad prospects for growth in the areas of planting this crop in semi-arid northeast . Several factors limit the productivity of Jatropha, with emphasis on the attack by pests such as spider mite Tetranychus bastosi Tuttle , Baker & Sales (Acari : Tetranychidae) . Among the methods currently used for alternative pest control is gaining prominence employment of plant extracts due to the presence of secondary metabolites present in some plants and their low toxicity to the environment and to humans . In the present work we evaluated the potential of plant extracts Myracrodruon urundeuva All Br ( Anacardiaceae ) , Croton blanchetianus Baill (Euphorbiaceae) and Ziziphus joazeiro Mart . (Rhamnaceae ) on the mite T. bastosi associated with the culture of Jatropha. We evaluated the effect of the extract of M. urundeuva at different doses (0 , 5 % , 10 % , 15 % , 20 % and 25 % ) on the biology and fertility life table T. bastosi . It was observed that the extract of M. urundeuva prolonged cycle of development of the mite and with increasing dosages, prolonged the longevity of T. bastosi . With respect to the life and fertility table, it was found that there was no effect of the extract for the parameters, except for the survival and viability of eggs, where there was a lower progeny survival at a dose of 10% and a lower egg viability in strengths of 15 % and 20 %. Toxicity and repellency of the extracts of M. urundeuva , C. blanchetianus and Z. joazeiro was also evaluated . Generally extracts showed toxic effect on adults of T. bastosi the concentrations tested. The extract of Z. joazeiro showed the highest mortality rates (90 %) mean mortality of individuals. With regard to the repellency of these extracts, all treatments were shown repellents for females of Tetranychus bastosi classified as repellent treatment, except for the 5% dose of extract of M. unrundeuva .
A produção de biodiesel vem recebendo bastante incentivo e dentre as culturas agrícolas com potencial para esta aplicabilidade destaca-se o pinhão-manso (Jatropha curcas L.), que vem sendo apontada como uma das mais promissoras para o biodiesel e inserção na cadeia produtiva familiar. Isso tem aberto amplas perspectivas para o crescimento das áreas de plantio desta cultura no semiárido nordestino. Diversos fatores limitam a produtividade do pinhão-manso, havendo destaque para o ataque por pragas, como o ácaro Tetranychus bastosi Tuttle, Baker & Sales (Acari: Tetranychidae), o qual foi registrado recentemente em Pernambuco. Dentre os métodos utilizados atualmente para o controle alternativo de pragas vem ganhando destaque o emprego de extratos vegetais, devido à presença metábólitos secundários presentes em algumas plantas e à sua baixa toxicidade para o meio ambiente e para o homem. No presente trabalho avaliou-se o potencial de extratos vegetais de Myracrodruon urundeuva Fr. All (Anacardiaceae), Croton blanchetianus Baill (Euphorbiaceae) e Ziziphus joazeiro Mart. (Rhamnaceae,) sobre o ácaro T. bastosi associado à cultura do pinhão- manso. Avaliou-se o efeito do extrato de M. urundeuva, em diferentes dosagens (0, 5%, 10%, 15%, 20% e 25%) sobre a biologia e a tabela de vida de fertilidade de T. bastosi. Observou-se que o extrato de M. urundeuva prolongou o ciclo de desenvolvimento deste ácaro e com o aumento das dosagens, houve um prolongamento da longevidade de T. bastosi. No que se refere à tabela de vida e fertilidade, verificou-se que não houve efeito do extrato para os parâmetros analisados, exceto para a sobrevivência e viabilidade de ovos, onde observou-se uma menor sobrevivência da progênie na dose de 10% e uma menor viabilidade de ovos nas dosagens de 15% e 20%. Também foi avaliada a toxicidade e repelência dos extratos de M. urundeuva, C. blanchetianus e Z. joazeiro sobre T. bastosi. De uma forma geral os extratos demonstraram efeito tóxico para adultos de T. bastosi nas concentrações testadas. O extrato de Z. joazeiro apresentou as maiores taxas de mortalidade (90% de mortalidade média dos indivíduos). No que se refere à repelência destes extratos, todos os tratamentos se mostraram repelentes para fêmeas de Tetranychus bastosi, classificados como tratamentos repelentes, exceto para a dosagem de 5% do extrato de M. unrundeuva.
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Macht, Lisa. « Human autoantibody production in SCID mice ». Thesis, University of Bristol, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.335368.
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Giraud-Héraud, Yannick. « Mise en évidence de la production ». Grenoble 2 : ANRT, 1988. http://catalogue.bnf.fr/ark:/12148/cb376139343.
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Lanke, Amol. « Mine Production Assurance Program- Development and Application ». Doctoral thesis, Luleå tekniska universitet, Drift, underhåll och akustik, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:ltu:diva-61123.
Texte intégralRésumé :
ssuring production forms a crucial part of mining business profitability. Factors related to various mine operations, activities and business processes can threaten required/planned mine production. To address problems and ensure production level in mining, it is necessary to implement a mine production assurance program (MPA). In order to propose a guideline and its component, this study started by reviewing four such techniques used in process industries. Comparing the tools, techniques and focus with mining productivity and production factors, it was observed that applicability of these methods for mining is limited due to lack of focus on equipment focus, cost focus and other parameters. Similarity of objectives and requirements of equipment focus lead to conclusion that PAP from oil and gas industry seems to be method which can guide MPA.\parAs a basis of MPA, an index is required to create a clear relationship between different situations which can occur in mining operation and production loss. A literature review on mining productivity improvement methods shows availability, utilisation and production performance of equipment are the key factors in determining overall production. A single index applicable for chain operation in mining is needed. A Mine Production index (MPi) is thus proposed. This index involves all three parameters for equipment productivity mentioned above. Weights associated with MPi calculation for bottleneck equipment can point out critical factors in equipment operation. Once bottleneck equipment and relevant critical factors are known, further analysis can be carried out to determine the possible causes of production loss. By using MPi for machine operations, it is possible to rank machines in terms of production effectiveness. When the study applied MPi to chain operations in a mining case study, a crusher was determined as bottleneck equipment.\parMining operation is heavily influenced by internal and external uncertainties. Operational uncertainties related to equipment includes its key factors leading to production i.e. availability, utilisation and performance. These factors are in turn dependent upon downtime, idle time, rated capacities. External parameters related to weather are based upon location of mining operation. Influence of these factors on production volume, could be used for better decision making during mining operations optimization. To effectively propose a method for correlating internal and external parameters with production volume, case studies in an open pit mine were conducted. During these case studies a multi-regression modelling methodology is used. It was found that at system level availability is important criteria for increasing production. At level of shovel and truck fleet, availability and utilisation are most important characteristics to be focused for reduction in production uncertainty. Environmental factors are although correlate to less variation in production volume compared to operational factors. Amongst considered environmental factors snowfall is highly influencing followed by rainfall. At system level use of maximum capacities of equipment and availability are key point for increasing production. Based on analysis of internal operational factors, it was concluded that capacity of shovel and trucks is underutilised. For shovels availability and idle time are influential factors. For trucks utilisation is highly correlated to production volume generated. Analysis of environmental factors concluded that, period of zero snowfall and rainfall are perfect condition for equipment production increase. Period when either snowfall or rainfall stabilisation are also equivalent to achieve higher production. Although these production levels are significantly less than period without snow and rain
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Page, Raymond Lynn. « Evaluation of techniques for the production of transgenic animals ». Diss., Virginia Tech, 1993. http://hdl.handle.net/10919/40112.
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Page, Raymond L. « Evaluation of techniques for the production of transgenic animals ». Diss., Virginia Tech, 1993. http://hdl.handle.net/10919/40112.
Texte intégralRésumé :
A polymerase chain reaction (PCR) technique was used to detect transgene presence after pronuclear microinjection of mouse zygotes cultured to various stages of development. The transgene was detected in 88% of 1-cell, 88% of 2-cell, 44% of 4-cell, 40% of morula, and 29% of blastocysts. By comparison, the integration frequency for transgenic mice made using the same DNA construct was 22%. After 5
days of in vitro culture, the injected construct was detected in 83% of arrested 1-cell, 85% of arrested 2-cell, and 85% of fragmented embryos. Only 28% of zygotes cultured after microinjection of DNA developed to the blastocyst stage compared to 74% of noninjected zygotes. When DNA buffer alone was injected, 63% of zygotes developed to the blastocyst stage. These data suggest that pronuclear microinjection of DNA is highly detrimental to subsequent embryonic development. Also, most injected DNA that is either unintegrated or that will not be integrated into the genome has been degraded by the blastocyst stage such that it can no longer be detected by PCR.
The production of transgenic mice by cytoplasmic injection of DNA mixed with poly-L-lysine is also described. The effects of DNA concentration and stoichiometric ratio of positive charges provided by the polycation to negative charges provided by DNA on transgenic frequency and embryonic viability were studied. The highest transgenic frequency (13% of pups born were transgenic) was obtained when a polylysine/DNA complex having a stoichiometric charge ratio of one to one (equal positive charges as negative charges) at a DNA concentration of 50 ug/ml was used. The transgenic frequency by pronuclear injection of the same DNA construct was 22%. The percentage of zygotes, cultured in vitro, reaching the blastocyst stage which were injected cytoplasmicly was not different (p>0.05) than that of control zygotes that were not microinjected (65% versus 74%, respectively). The percentage of zygotes reaching the blastocyst stage after pronuclear microinjection with DNA at a concentration of 1.5 ug/ml was significantly lower (p<0.05) than control embryos (28% versus 74%, respectively). The overall transgenic pup production efficiency (percent of transgenic pups per embryos transferred) by cytoplasmic injection was 2.4% compared to 3.5% by pronuclear microinjection.Ph. D.
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McCament, Benny K. « Hydrologic controls on acidity and metals production in an abandoned underground mine complex in southeast Ohio, Perry county ». Ohio University / OhioLINK, 2004. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1088185432.
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Marinho, de Almeida Alexandre. « Surface constrained stochastic life-of-mine production scheduling ». Thesis, McGill University, 2013. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=117214.
Texte intégralRésumé :
The maximization of mining project discounted cash flows by defining the best sequence of extraction of underground materials requires understanding the availability of uncertain metal quantities throughout the deposit. This thesis proposes two versions of a stochastic integer programming formulation based on surfaces to address the optimization of life-of-mine production scheduling, whereby the supply of metal is uncertain and described by a set of equally probable simulated orebody models. The first version of the proposed formulation maximizes discounted cash flows, controls risk of deviating from production targets and is implemented sequentially, facilitating production scheduling for relatively large mineral deposits. Applications show practical intricacies and computational efficiency. The second variant extends the first to a two-stage stochastic integer programming formulation that manages the risk of deviating from production targets. The sequential implementation is considered first for pit space discretization and it is followed by the life-of-mine production scheduling at a relatively large gold deposit. The case studies show the computational efficiency and suitability of the method for realistic size mineral deposits, with production targets controlled, risk postponed to later stages of production and improvements in expected NPV, when compared to deterministic industry practices.La maximisation du flux de trésorerie actualisé des projets miniers fait en définissant la meilleure séquence d'extraction de matériaux souterrains exige une bonne compréhension de l'incertitude sur la disponibilité de la quantité de métal provenant du gisement souterrain. Ce mémoire propose deux formulations basées sur des surfaces afin d'optimiser la séquence d'extraction tout au long du projet où la quantité de métal est incertaine et décrite par un ensemble de simulations équiprobables. La première simulation maximise le flux de trésorerie actualisé, contrôle le risque d'écart par rapport aux objectifs de production et est implémentée de façon séquentielle, ce qui facilite la planification pour des gisements relativement grands. L'application de cette formulation sur des problèmes montre une complexité pratique et une efficacité computationnelle. La seconde formulation étend la première en une formulation stochastique en nombres entiers à deux étapes qui permet de gérer le risque d'écart par rapport aux objectifs de production. L'implémentation séquentielle considère d'abord une discrétisation du gisement puis génère une séquence d'extraction annuelle et est appliquée sur un dépôt d'or de grande taille. Les études de cas montrent l'efficacité computationnelle et une adaptation adéquate pour des problèmes de taille réelle avec des objectifs de production contrôlés, un risque reporté à des étapes ultérieures du développement et une amélioration dans la valeur nette actualisée comparée aux meilleures pratiques déterministes de l'industrie.
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Vermeulen, Adriaan. « Methods to optimise underground mine production / Adriaan Vermeulen ». Thesis, Potchefstroom University for Christian Higher Education, 2002. http://hdl.handle.net/10394/9717.
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The focus of this study was to investigate the current underground conventional
mining systems used in the platinum mining industry and to design a mine
production planning system to optimise the conventional operations - Anglo
Platinum specific. The maximum steady state micro output levels of underground
mines were determined from a mining and engineering perspective and the GAP,
or output potential compared to the current output levels, was established. All
the production facility's requirements with regard to services, equipment and
infrastructure to achieve optimum production levels were calculated from first
principles and a modelling tool for technical and mining optimisation evaluations
was designed for use by the operations. Furthermore, an analysis of the main
infrastructure or so-called "ongoing capital development" was done as a means
to determine the maximum sustainable shaft capacities.
With the main objective being to determine the existing production GAP and
thus the requirements to fill this GAP, a picture of the current conditions,
equipment capacities and output levels were determined. For this purpose,
specific checklists were designed to capture all the relevant information. It was
sub-divided in such a way that inputs could be made in a logical sequence to
prevent backtracking exercises. The existing infrastructure and equipment were
rated on a scale ranging from zero to ten with zero meaning non-existent and
ten being brand new. The involvement of the site personnel throughout the
entire process is a crucial part of the exercise as buy-in and ownership are
probably the most important aspects of any implementation process. This buy-in
was achieved through planning workshops and presentations where real
examples from the audience where modelled. Members were allowed to change
parameters and outcomes were debated. The systematic logical approach and
the suite of practical outputs sold the system during every session held. Support
came from all functions including mine design specialists and ore resource
managers using different systems.
The mining industry is the largest source of foreign income for South Africa and
it is also the main source of employment with Anglo Platinum employing in the
region of forty thousand employees1 and contractors. Reef deposits are not
replaceable and it is in the interest of all stakeholders to extract every unit in the
most efficient manner. Mines require vast amounts of capital and with risks like
fluctuating metal prices, exchange rates, rising costs, labour unrest and
geological uncertainties, it is important to have optimum planning and
management systems in place. This project focused on how to optimise the
output levels of current operations thus minimizing all of the mining-related risks
in a direct or indirect manner. It is a simple means to leap closer to mining
professionalism in first-world countries.
The GAP varied between the different operations and ranged between overproduction
and 60% below the optimum potential. On average it was 50% below
optimum performance levels2. It has to be noted that these observations are
based on half levels outputs and not on shaft capacities. In other words, where
shafts are operating at design capacities, the same production can be obtained
by manning half the amount of levels implicating cost savings instead of
increased production. The current planning practices are thus not adequate to
truly optimise the operations.MIng (Mechanical Engineering), Potchefstroom University for Christian Higher Education, 2003
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Fujiwara, Hideya. « Curcumin inhibits glucose production in isolated mice hepatocytes ». Kyoto University, 2008. http://hdl.handle.net/2433/124224.
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Gauthier, Christophe. « La mise en scène cinématographique dans le webfilm de fiction ». Aix-Marseille 1, 2008. http://www.theses.fr/2008AIX10035.
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La présente étude porte sur la notion de mise en scène cinématographique confrontée au webfilm de fiction en prise de vues réelles. Dans un premier temps, nous avons cherché à comprendre et à définir la notion de mise en scène utilisée à l'endroit du cinéma, mais pourtant peu étudiée en théorie du cinéma. Pour combler ce vide théorique, nous avons décortiqué cette notion pour la construire en un outil capable d'analyser le webfilm de fiction en prise de vues réelles, proche et en même temps différent du film de cinéma. Dans un second temps, nous avons voulu savoir si la "mise en scène " dite cinématographique ainsi constituée, considérant autant l'entité créatrice que l'entité réceptrice, restait une notion opérationnelle pour l'analyse de ces nouveaux objets-films que nous trouvons sur le Web, qu'ils soient interactifs ou linéaires. Une étude qui nous amène de la scénographie vitruvienne au coeur des nouveaux médias.
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Boudou-Maule, Liliane. « La gestion de production dans les entreprise : organisation, conditions de mise en oeuvre ». Toulouse 1, 1991. http://www.theses.fr/1991TOU10030.
Texte intégralRésumé :
L'informatique s'impose de plus en plus dans les entreprises et de nos jours, on assiste à un élargissement des fonctions automatisées, c'est ainsi qu'après les services administratifs, ce sont ceux de la production qui le sont. L'objectif de ce travail est de faire le point sur la gestion de production et son informatisation. Il nous a paru important de connaitre ce qui se pratique, c'est-à-dire l'existence de méthodes actuellement usitées, les apports réels de l'informatique, les étapes de la mise en œuvre de celle-ci, ainsi que la place de la formation. Il nous a semblé intéressant de faire une "photographie" puis une analyse de la gestion de production assistée ou non par ordinateur dans notre région, et de proposer une méthodologie de mise en œuvre d'une gp ou gpao. Pour cela, il était indispensable de retracer l'historique de l'organisation de la production et d'étudier les différentes méthodes existantes pour gérer la productionComputer science is being used more in industry. After the automation of the administrative and commercial sectors. It is production which is being computerides. The object of our work is to take stock of present position of production control and its automation. It is important for us to know what has already been done, what methods are used (if methods exist), the advantages of computing, the steps taken to set up computerised systems and what is the place for training. It seemed worthwhile to take a "photo" of the present situation, to analyse whether or not the production control process was automated in our region, and to propose a methodology of setting up computerised production. We were thus obliged to carry out a historic study of the organisation of production and to look at the different methods of managing production
16
Moruppa, Saidu M. « Genetic studies of food intake and energy metabolism in mice ». Thesis, University of Edinburgh, 1989. http://hdl.handle.net/1842/15440.
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Reid, Gregory Kenneth. « Bone marrow B lymphocyte production in immunologically defective mice ». Thesis, McGill University, 1987. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=63822.
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Allison, Jacqueline. « A computer-based mine development and production management game ». Thesis, McGill University, 1994. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=28658.
Texte intégralRésumé :
A model of the sequence of decisions required for mine development and production has been formulated and is operated as a computer-based game. The Mine Manager is an operations research game in which the user assumes the role of mine management in the exploitation of a mineral deposit. Potential applications of the game lie in experimentation, policy formulation and education in mine economics. The Mine Manager is described using the terminology of games.The selection of parameters and of the level of detail in the model reflects a compromise between realism and simplicity. At the development stage, the selection of project specifications concerns the mining method and capacity installation. Decisions on cut-off grade and/or cut-off value, capacity utilization, the sequence of mining, stockpiling and expansion are made during the mine life. Decision making takes place within a framework provided by an abstraction of the operating environment of a mine, and must comply with a set of rules. These rules ensure that only feasible decisions are made. Within this constraint, the model offers a high degree of flexibility in setting the values of the decision variables.
The Mine Manager combines elements of geology, mining, management and gaming. Conditional simulation is used to generate grades of copper, zinc and gold in a massive sulphide deposit. Mining operations in both underground and open-pit mines are modelled, and hypothetical capital and operating cost functions are developed for the mine and mill. A pricing model generates new price series for each run of the game.
The Mine Manager is operated interactively on a microcomputer through the use of modular software. The user interface and a sample run of the game are described, and the information displays created by the game are presented.
19
Kasmi, Fouziya. « La production mixte des locuteurs bilingues français-arabe algérien ». Paris 8, 2012. http://www.theses.fr/2012PA083971.
Texte intégralRésumé :
Le phénomène du code switching caractéristique du parler bilingue, où les locuteurs sont susceptibles d'utiliser les ressources linguistiques de plusieurs systèmes et d'alterner entre l'un et l'autre au cours d'une même conversation pose la question fondamentale en linguistique sur l'articulation entre forme et fonction. Afin d’étudier et de décrire ce phénomène, il est nécessaire de traiter deux questions au préalable : la première concerne la classification des autres manifestations de contact des langues; la seconde relève de la confrontation entre les prédictions faites dans les différentes théories existantes et les données relatives au comportement langagier des bilingues recueillies. La typologie de Muysken (2000) semble la plus pertinente et la plus adéquate car elle reprend les principaux travaux sur le sujet (comme le MLF de Myers Scotton 1993, et les contraintes de Poplack 1981) et définit trois processus réutilisés dans ce travail : 1) l’insertion d’éléments d’une langue dans la structure d’une autre 2) l’alternance entre les structures des deux langues 3) la congruent lexicalization d’éléments des deux lexiques dans une structure grammaticale partagée. Cette étude met l’accent sur un objectif principal qui est de décrire le(s) type(s) de processus de CS que les locuteurs utilisent selon leur profil sociolinguistique. En d’autres termes, est-ce que les différents facteurs sociobiographiques et situationnels peuvent influencer l’utilisation du code switching dans ses différents processus? La compétence linguistique exerce-t-elle une influence notable dans cette utilisation? Et quelle est la part des facteurs sociolinguistiques et celle des facteurs linguistiques?The code switching phenomena, where the speakers may use the linguistic resources of several systems and alternate between both during the same conversation, asks the fundamental question in linguistics on the articulation between form and function. To study and describe this phenomena, it is necessary to consider two questions beforehand: the first deals with the classification of the other demonstrations of contact of languages; the second covers the confrontation between predictions made in the various existing theories and datas. The typology of Muysken (2000) seems the most relevant and the most adequate because it summarizes the main researches on the subject (in particular the MLF of Myers Scotton 1993, and the constraints of Poplack 1981) and defines three processes that we used in this work: 1) The insertion of elements of a language in the structure of the other one ; 2) The alternation between the structures of both languages; 3) The congruent lexicalization of elements of both lexicons in a shared grammatical structure. This study emphasizes a main objective which is to describe the type(s) of process of CS in the typology of Muysken which the speakers use according to their sociolinguistic profile. In other words, can the various sociobiographic and contextual factors influence the use of the CS in its various processes? Does the language skill influence significantly this use? And what is the part of the sociolinguistic factors and that of the linguistic factors?
20
Mayeku, Jukie K. « The Effects of Aldehydehydrogenase1A1 on Immunoglobulin Production in Mice ». The Ohio State University, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=osu1281035253.
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Cai, Wenlong. « ZERO-ONE PROGRAMMING ANALYSIS OF MINE PRODUCTION SCHEDULING PROBLEMS ». Thesis, The University of Arizona, 1985. http://hdl.handle.net/10150/275401.
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Herjanto, Eddy. « Multi stage approach to mine scheduling ». Ohio : Ohio University, 1991. http://www.ohiolink.edu/etd/view.cgi?ohiou1183729474.
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23
Asante, Emmanuel A. « Biochemical genetics of lipid metabolism in chickens and mice ». Thesis, University of Edinburgh, 1988. http://hdl.handle.net/1842/11520.
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Jouve, Romain. « Mise au point de synthèses de stéroïdes : perspectives d'applications industrielles ». Thesis, Université Clermont Auvergne (2017-2020), 2017. http://www.theses.fr/2017CLFAC016.
Texte intégralRésumé :
L’objectif des travaux de thèse est l’amélioration du coût de revient industriel du décortidiène, intermédiaire clé dans la préparation de plusieurs principes actifs produits au sein de l’usine de production de SANOFI Vertolaye. Après une revue de l’état de l’art sur la synthèse du décortidiène et en fonction du cahier des charges défini, deux voies ont été explorées. La première voie de synthèse étudiée a permis de préparer le décortidiène en deux étapes, alors que la synthèse industrielle est effectuée en quatre étapes. Cependant, le rendement encourageant obtenu est inférieur à l’objectif fixé. Une étude de modélisation moléculaire a permis de proposer un mécanisme réactionnel concernant cette voie. Nous avons pu mettre en évidence lors de cette synthèse la formation d’un nouveau coricostéroïde, présentant une activité anti inflammatoire comparable à celle de la prénidsolone. La deuxième voie de synthèse permet de réduire le nombre d’étapes de la synthèse du décortidiène de 25% et conduit à un rendement acceptable par rapport à celui défini dans le cahier des charges. Le procédé a fait l’objet de plusieurs séries par une approche « plan d’expériences » pour atteindre les objectifsThe aim of this doctoral works is the reduction of the production costs of decortidiene made by SANOFI Vertolaye. Decortidiene is a key intermediate for the synthesis of several active principles. After checking the iterature, two ways were explored. The first one reduces by half the synthetic steps buthe yield is lower than the target. A molecular modeling allowed us to propose a reaction mechanism. Several optimizations and experimental design of experiments enabled the second studied pathway to reduce by 25% the industrial process and to reach the targeted yield
25
Beaufort, Philippe. « Le projet de l'action créatrice ». Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/nq25380.pdf.
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Ross, Wanda. « The Westray Mine explosion : The production of a public inquiry ». Thesis, University of Ottawa (Canada), 2001. http://hdl.handle.net/10393/9299.
Texte intégralRésumé :
The Westray Mine disaster, that occurred on May 9, 1992 in Pictou County, Nova Scotia led to the death of twenty-six miners and has been linked to gross corporate violations. A public inquiry into the Westray Mine explosion was called on May 15, 1992 by Nova Scotia premier Donald Cameron. In this thesis a qualitative discourse analysis is applied to the examination of the Westray Mine Inquiry Report, the seventy-four recommendations from the Inquiry and a sample of the Inquiry transcripts. This research includes the exploration of the key players, problematizations which emerged in the discourse, the formal and informal rules and the relationships of truth and power. There is also an analysis of several key themes, including: the nature of the Inquiry discourse, the Inquiry's conceptualization of risk and its construction of the distinction between the private and public sectors. The theoretical framework for this thesis was provided by literature on governmentality which I found particularly pertinent to the analysis of public inquiries. In this thesis, the governmentality framework was helpful in formulating research questions and an analytics of government approach provided useful research guidelines for my study. Public inquiries are also analyzed as an example of reflexive government since they react to governability problems by including the public and developing recommendations for changes in the governing style. The aim of this thesis is to examine how the Westray Mine Inquiry evolved as a form of governing. This is accomplished through an exploration of mechanisms, practices and discourses related to the production of the Inquiry. The thesis traces its frame of reference, formal and informal rules, power relations, hierarchies of knowledge, tactics, rules of inclusion and exclusion as well as the relationship between the Inquiry discourse and the final set of recommendations.
27
Mabed, Malha. « Evaluation et mise en oeuvre des systèmes de production cyclique ». Phd thesis, Ecole Nationale Supérieure des Mines de Saint-Etienne, 2005. http://tel.archives-ouvertes.fr/tel-00850443.
Texte intégralRésumé :
L'évolution de l'environnement des entreprises a transformé la nature des relations entre elles, qui de simple relations d'achat entre clients et fournisseurs se sont transformées en des rapports plus contractualisés et plus durables. Ces derniers imposent à ces entreprises de revoir leurs méthodes de gestion et de production pour une meilleure synchronisation de leurs flux. Nous nous intéressons dans ce mémoire à une relation particulière entre clients et fournisseurs, celle fondée sur le principe de livraisons cycliques, selon lequel le fournisseur s 'engage à livrer des quantités de produits à des intervalles de temps fixes et de façon répétitive. L'intérêt de ce mode de livraison et qu'il permet, aux donneurs d'ordres, une gestion extrêmement simple des approvisionnements et facilite l'organisation des activités. Comme réponse à ce type de livraisons et afin de synchroniser leurs flux de production à ceux de livraisons, les entreprises adoptent la production cyclique. L'avantage de cette dernière est qu ;elle permet entre autres de réduire les coûts engendrés par la fabrication, et de simplifier l'organisation du travail. Notre travail consiste alors en l'évaluation et la mise en oeuvre d'un plan de production cyclique, pour un atelier de type Flow Shop pur fabricant plusieurs produits, lorsque les appels de livraisons sont cycliques. Nous proposons une nouvelle méthode déterminant un plan de production cyclique minimisant des coûts de lancements, coûts de stockage et des coûts de fabrication. Nous introduisons dans un premier temps le contexte -de notre travail en précisant les différentes hypothèses que 1 'on pose. Nous proposons par la suite une revue de la littérature sur les différents travaux réalisés, et proposons une classification des problèmes traitant de la production cyclique étudiés par la communauté scientifique. Nous exposons également la méthode que l'on propose pour la détermination d'un plan de production cyclique minimisant les différents coûts que l'on considère. Nous présentons une analyse des résultats issus de l'application de notre approche ainsi que ses variantes sur un ensemble de benchmarks générés aléatoirement et respectant les traits caractéristiques des problèmes réels. Nous réalisons une étude comparative d?s approches que l'on propose à 1 'une de celles proposées dans la littérature. Nous terminons ce mémoire par une conclusion et un ensemble de voies de recherches futures.
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Fathollahzadeh, Karo. « Long-term Open-pit Mine Production Scheduling with Grade Engineering ». Thesis, Curtin University, 2022. http://hdl.handle.net/20.500.11937/89233.
Texte intégralRésumé :
Open pit mine production scheduling is a strategic decision-making problem that plays an important role in surface mining, as the economic viability of a mining project is highly dependent on careful long-term planning. An open pit mine production schedule seeks to determine the optimal sequence for a mineral deposit and the flow of materials within a mineral value chain (i.e., stockpiles, waste dumps and processing streams). This thesis investigates open pit mine production scheduling with the incorporation of Grade Engineering. The Grade Engineering concept was introduced by the Cooperative Research Centre for Optimising Resource Extraction. This thesis then, for the first time in the literature, develops and implements a new mixed-integer programming formulation for open pit mine production scheduling that considers Grade Engineering preconcentration techniques.
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Frisk, Julia, et Linnéa Johansson. « Mitt jobb är mitt jobb och mitt liv är mitt liv : En kvalitativ studie om kvinnliga enhetschefers psykosociala arbetsmiljö inom den kommunala äldreomsorgen ». Thesis, Högskolan i Borås, Akademin för vård, arbetsliv och välfärd, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:hb:diva-23710.
Texte intégralRésumé :
Allt högre krav ställs på såväl samhälle, organisation som individ. Dagens organisationer präglas av ett högt arbetstempo som innefattar höga krav. Det leder till en ansträngd arbetsmiljö, vilket i sin tur kan vara en bidragande faktor till den psykiska ohälsa som breder ut sig i samhället. Kvinnodominerade branscher innehar en hög grad av psykosocial arbetsbelastning vilket avspeglas i sjukfrånvarostatistiken. Denna studie syftar till att skapa en djupare förståelse om kvinnliga enhetschefers psykosociala arbetsmiljö. Resultaten tolkas med hjälp av teorier tillämpbara på arbetsmiljöområdet. En kvalitativ metod har tillämpats genom sex stycken semistrukturerade intervjuer som genomförts med enhetschefer verksamma inom vård- och omsorgssektorn. Resultaten visar att enhetscheferna har ett stort arbetsengagemang, en hög arbetsbelastning, ett till viss del begränsat handlingsutrymme, en känsla av otillräcklighet men ett starkt socialt stöd från närmaste chef och chefskollegor. Förutsättningar som understödjer en hälsorelaterad hållbarhet hos kvinnliga enhetschefer inbegriper bland annat tydligare gränsdragningar och arbetsbeskrivningar, en kartläggning av kompetens, minskade personalgrupper och utrymme för dialog.Increasing demands are placed on society, organizations and the individual. Today's organizations are characterized by a high pace of work that includes high demands. This leads to a strained working environment, which in turn can be a contributing factor to the mental illness that is spreading in society. Female-dominated industries have a high degree of psychosocial workload, which is reflected in sick leave statistics. This study aims to create a deeper understanding of the psychosocial work environment of female unit managers. The results are interpreted using theories applicable in the field of occupational safety and health. A qualitative method has been applied through six semi-structured interviews conducted with unit managers active in the health care sector. The results show that unit managers have a high level of work involvement, a high workload, to some extent limited latitude, a sense of inadequacy, but a strong social support from the immediate manager and senior colleagues. Conditions supporting the health-related sustainability of female unit managers include clearer boundaries and job descriptions, skills mapping, reduced staff groups and room for dialogue.
30
Welman, Shaun. « Seasonal changes in the heat production of an African small mammal, Rhabdomys pumilio ». Thesis, Nelson Mandela Metropolitan University, 2012. http://hdl.handle.net/10948/21417.
Texte intégralRésumé :
Endothermy refers to the ability of an individual to produce heat from internal sources, and allows animals to maintain a body temperature that is higher than their external environment. Although much is known about the benefits of endothermy, its origin is highly debated. Nonetheless, due to environmental variation, endotherms have to regulate their heat production (thermogenesis) in order to remain normothermic. An endotherms regulatory response seems to be body size dependent. Keeping warm during cold periods is energetically expensive, and for small mammals this is exacerbated by their high rate of heat loss due to high surface area to volume ratios. To compensate for the heat lost, small non-hibernating mammals must increase their level of thermogenesis. Much of our current understanding of thermogenic responses of small mammals is derived from laboratory acclimated animals, and studies on naturally acclimatized animals are uncommon. In addition, most studies on thermogenesis tend to focus on one level of animal organisation, such as subcellular, tissue or in-vivo, but seldom integrate these data. The aim of this study was to measure year-round variation in thermogenesis across all levels of organisation, using naturally acclimatized Rhabdomys pumilio individuals from the Nelson Mandela Metropolitan University, Port Elizabeth. It was predicted that the level of thermogenesis would be significantly higher during winter relative to other seasons in order to cope with the low ambient temperatures (Tas) experienced during this season. Open flow respirometry was used to measure the animal's oxygen consumption, as a proxy for metabolism; the by product of which is heat production. The animal's basal metabolic rate (BMR), nonshivering thermogenesis (NST) capacity and summit metabolic rate (MSUM) were measured. A Western blot analysis was used to determine the expression of uncoupling protein 1 (UCP 1) in the animals' brown adipose tissue (BAT), as well as determine its relative concentration. The cytochrome c oxidase (COX) activity of the animals' visceral organs and BAT was measured, as an indicator of the tissues' metabolic activity. COX activity was determined as the difference in the tissues' oxygen consumption before and after the addition of horse cytochrome c.
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ROUCOU, PHILIPPE. « Definition et mise en oeuvre d'un plan directeur de production : de fallacieuses simplicites ». Paris, ENMP, 1989. http://www.theses.fr/1989ENMP0146.
Texte intégralRésumé :
Les difficultes posees par la mise en oeuvre d'un plan directeur de production sont analysees: problemes generaux, grands types de programmations, reseaux de distribution et contexte multi-usines. On met ensuite en evidence, le lien entre la fonction logistique et le plan directeur. On presente un cas concret
32
Leblanc, Pierrick. « Sélection et mise en oeuvre "optimale" de souches microbiennes en bioréacteur, pour la production d'acide hyaluronique ». Thesis, Université de Lorraine, 2014. http://www.theses.fr/2014LORR0228/document.
Texte intégralRésumé :
Ce travail se proposait de développer, à l’échelle du laboratoire, un procédé de production microbienne d’acide hyaluronique (AH), biopolymère d’intérêt pour la cosmétique et la santé, chez une bactérie lactique naturellement productrice, Streptococcus zooepidemicus. Une étude bibliographique a permis d’identifier les points potentiellement critiques pour ce travail qui sont la composition du milieu de culture (identification de nutriments essentiels à la synthèse d’acide hyaluronique), les conditions opératoires et plus particulièrement d’oxygénation (transfert d’oxygène mais aussi maintien du potentiel d’oxydo-réduction), en relation avec les performances de production et le métabolisme des souches considérées. Une étape préliminaire a consisté en un développement et une amélioration de techniques analytiques pour disposer d’outils pertinents de suivi du métabolisme de Streptococcus zooepidemicus. La quantification de la biomasse hors acide hyaluronique ainsi que la détection de l’activité hyaluronidasique ont ainsi été développées tandis que d’autres méthodes chromatographiques et enzymatiques ont été simplement appliquées et validées aux substrats et métabolites considérés. La mise en œuvre de souches « environnementales » prélevées sur des sites infectieux chez le cheval, ainsi que de souches de collection, a permis dans un premier temps de formuler un milieu de culture et de définir des conditions de mise en œuvre exploitables à plus grande échelle pour la production d’AH. Des résultats très encourageants ont pu être obtenus avec des productions d’AH supérieures aux essais de la littérature, tout en mettant en avant des facteurs influents cruciaux tels que la concentration initiale en glucose ou encore l’oxygénation des cultures. L’influence de ces facteurs a été étudiée par la suite par le biais de cultures en bioréacteur de laboratoire en modes discontinu et discontinu-alimenté avec pour résultat l’obtention d’un mode de mise en œuvre et de conditions physico-chimiques de production améliorées. En parallèle, une étape importante de ce travail a consisté en une approche d’amélioration de souches « environnementales » par mutagénèse aléatoire, les performances de ces souches s’avérant initialement décevantes. Des mutants surproducteurs ont ainsi été générés, caractérisés au niveau de leurs performances métaboliques et conservés. En dernier lieu, un des mutants les plus performant a été mis en œuvre dans les conditions et le mode de culture sélectionnés précédemment. Tant le niveau de production d’AH, la productivité associée, que les tailles obtenues ont permis de valider ce travail de développement d’un procédé microbien de production d’AH, tout en identifiant de nouvelles voies d’améliorationThis work intended to develop a laboratory scaleproduction process ofhyaluronic acid (HA), a biopolymer of health and cosmetic interest, using a naturally AH producing lactic acid bacterium, Streptococcus zooepidemicus. A literature review allowed to identify the following critical points: firstly, the composition of the culture medium (identification of essential nutrients for microbial growth and synthesis of HA), secondly, the oxygenation level (oxygen transfer and associated redox modifications), and finally, in relation with, the production and metabolism abilities of the considered strains. A preliminary step was dedicated to the developmentorthe improvementof analytical techniques in order todispose of appropriate tools for the monitoring of Streptococcus zooepidemicus metabolism. The quantification of the biomass without considering capsular HA fraction as well as detection of hyaluronidase activity have been developed while other chromatographic and enzymatic methods have been more basically applied to and validated with the substrates and metabolites considered. The laboratory scale cultures of collection (ATCC) as well as “environmental” strains were initially used to formulate a workable cultivation broth and to define suitable culture conditionsfor a use at a larger scale to produce HA. Very positive results were obtained with higher production of HA in comparison with literature assays, while critical influencing factors such as the initial glucose concentration or the oxygenation levelin cultures were highlighted. The influence of these factors was thoroughly studied with bioreactor cultures in both batch and fed-batch modes leading to improved cultivation conditions and culture mode. In parallel, another important step consisted in the highly performance improvement of initially low HA producing "environmental" strains via random mutagenesis. Very promising overproducing mutants have therefore been generated, characterized in their kinetic and metabolic capabilities and long-term stored. At last, one of the best and most reliable mutant has been cultivated with the best previously selected medium composition and operating conditions. Both the HA production level, productivity and size observed validated the findings of this process development work, while helping to identify new improvement domains and strategies
33
Janse, Van Rensburg Marjorie. « Nutritive value of tall fescue (Festuca arundinacea) established on rehabilitated mineland for grazing cattle ». Diss., University of Pretoria, 2013. http://hdl.handle.net/2263/40338.
Texte intégralRésumé :
Sustainable animal production on pasture planted on rehabilitated mine land will only be possible if
the optimal stocking rate for animal and pasture production is determined. A grazing trial was
conducted on tall fescue, established on rehabilitated mine land and irrigated with mine waste
water. The aims of this study were to quantify: a) animal performance and nutritive value at
different levels of nitrogen (N) fertilization during pasture establishment, and b) intake, animal
performance (defined as average daily gain; ADG) and nutritive value when different stocking rates
were applied. This study was done during two seasons: season one in winter (6 June -16 July
2008) and season two in spring (28 Aug – 6 Nov 2008). In terms of post mining land use this study
supplied valuable information on potential livestock production.
The higher level of N fertilization applied during the winter of 2007 at pasture establishment
resulted in a significantly (P < 0.05) higher crude protein (CP) concentration a year later compared
to the lower levels of N fertilization. During the winter grazing season the pasture contained an
average of 83.4 g CP kg-1 dry matter (DM), 601.9 g NDF kg-1 DM, 6.2 g Ca kg-1 DM and 1.7 g P kg-1
DM, the average in vitro organic matter digestibility (IVOMD) was 642.2 g kg-1 OM and the average
leaf: stem ratio was 88:12. The ADG of crossbred weaner calves grazing the low N fertilization
(LN), low stocking rate (LS) paddock (229.1 g day-1) was significantly (P < 0.05) lower than the
ADG of weaner calves grazing the LN, high stocking rate (HS) and the high N (HN), LS
respectively. The ADG of the animals in the HN, LS paddock was 482.7 g day-1 and in the LN, HS
paddock was 310.6 g day-1. The low ADG for the LS treatment was due to the low CP
concentration of this paddock, with values as low as 55.1 g CP kg-1 DM recorded during the winter
grazing period. Low pasture nutritive value during winter can potentially limit animal production.spring grazing season the pasture contained an average of 101.0 g CP kg-1 DM, 639.1
g NDF kg-1 DM, 8.9 g Ca kg-1 DM and 2.1 g P kg-1 DM. The average leaf: stem ratio was 85:15,
IVOMD was 717.5 g kg-1 OM and effective DM degradability (in situ) was 56.1 %. The average OM
digestibility estimated with the alkane method varied between 720.8 to 768.3 g kg-1 depending on
the alkane used and weather a correction was made for the faecal recovery of the alkane used. On
average the forage available in the paddock with the LS had a significantly (P < 0.05) higher CP
concentration, leaf: stem ratio and IVOMD, with a significantly (P < 0.05) lower NDF concentration
than the HS paddock. This is probably due to the fact that in the HS paddock forage with a high
nutritive value was removed at a higher rate. Irrespective of the calculation used, digestibility
calculated by the alkane method did not differ significantly (P > 0.05) between paddocks at any
time period. The average intake in the paddock with medium grazing stocking rate (MS) was
significantly (P < 0.05) higher than the average for the other paddocks. The paddock with the MS was managed to supply a pasture DM allowance of 2.5 % body weight (BW). The DM intake over
the spring season was 2.2 % BW. The MS treatment supplied sufficient plant material without
resulting in large accumulation of plant material. The ADG for the spring season was 110.5 g day-1
and averages for each paddock did not differ significantly (P > 0.05) from each other.
During theDissertation (MSc Agric)--University of Pretoria, 2013.
gm2014
Animal and Wildlife Sciences
unrestricted
34
Slifka, Janet Louise Khoenle 1964. « Respiratory constraints on speech production at prosodic boundaries ». Thesis, Massachusetts Institute of Technology, 2000. http://hdl.handle.net/1721.1/9027.
Texte intégralRésumé :
Thesis (Ph.D.)--Harvard--Massachusetts Institute of Technology Division of Health Sciences and Technology, 2000.Includes bibliographical references (p. 133-137).
This research characterizes the respiratory system dynamics at the initiation and termination of utterances and determines correlations of physiological measures with acoustic cues for these prosodic boundaries. The analysis includes boundaries within a breath as well as boundaries that are aligned with the initiation and termination of exhalation. Simultaneous recordings of the acoustic signal, airflow, esophageal pressure and lung volume were collected during read isolated utterances and short paragraphs. These measures were used to derive estimates of recoil forces of the chest wall, net muscular forces, and the area of the airway constriction. Data are presented from four subjects (two men, two women), all native speakers of American English. Perceptual ratings for initial and final prominent syllables and the locations of pauses within the utterance were also collected. For speech boundaries th.i.t are aligned with breath boundaries, utterance initiation occurs during a rapid transition in muscular effort. Sound begins as soon as conditions permit and these conditions consistently occur during net inspiratory muscular force. Alveolar pressure reaches an initial peak (PpI) that is, in most cases, correlated to the relaxation characteristic of the chest wall. The timing of Pp1 generally coincides with a prominent syllable if that syllable is the first or second syllable in the utterance and precedes later prominences. Pressure at phonation onset is, on average, near 0.3PpI for utterances initiated with a voiced sonorant and is near 0. 8Pp1 for utterances initiated with a voiceless fricative. Phonation termination results from an approximately 3-fold increase in glottal area and a J-3 cm H20 fall in pressure. Irregular fundamental frequency (FO) at the end of voicing, in many cases, does not fit the classical definition of glottalization. Instead, voicing terminates with increasing glottal area, and FO becomes irregular during the increase. In some cases, regular FO resumes as glottal area continues to increase. Distinct respiratory gestures are made at pauses within a breath. The pressure is reduced by 2-3 cm H20, on average, during a period of relatively little volume change. The findings in this research show that the role of the respiratory system in speech production goes beyond a more traditional view of this role as one of simply providing a relatively constant driving pressure during speech.
by Janet Slifka.
Ph.D.
35
Hernúñez, Pollux. « La mise en scène dans la Rome antique ». Paris 4, 1987. http://www.theses.fr/1987PA040038.
Texte intégralRésumé :
Pendant huit siècles le théâtre romain a évolué dans toutes ses formes: la farce, la comédie, la tragédie, le mime, la pantomime. Les pièces conservées (Plaute, Terence, Sénèque) et les témoignages indirects, écrits ou figurés, permettent de reconstruire la nature particulière des éléments constitutifs de ce théâtre en tant que spectacle: la scène, les décors, les machines, les masques, les costumes, l'accessoire, le jeu de l'acteur, la déclamation, le chant, la musique. Le théâtre actuel ne pourra que bénéficier de la recréation archéologique des spectacles romainsFor eight centuries roman drama has evolved in all its forms: farce, comedy, tragedy, mime, pantomime. The plays that have come down to us (Plautus, Terence, Seneca) and other evidence, either written or archeological, allow us to recreate the particular nature of the different elements of production: the stage, the sets, the machines, masks, costumes, props, acting, speech, song, music. Modern drama can only profit from the archeological re-production of roman plays
36
Andersen, Mats Grønning. « Reservoir Production Optimization Using Genetic Algorithms and Artificial Neural Networks ». Thesis, Norwegian University of Science and Technology, Department of Computer and Information Science, 2009. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-9985.
Texte intégralRésumé :
This master's thesis has investigated how methods from artificial intelligence (AI) can be used to perform and augment production optimization of sub-sea oil reservoirs. The methods involved in this work are genetic algorithms (GAs) and artificial neural networks (ANNs). Different optimization schemes were developed by the author to perform production optimization on oil reservoir simulator models. The optimization involves finding good input parameter values for certain properties of the model, relating to how the wells in the oil reservoir operate. The research involves straightforward optimization using GAs, model approximations using ANNs, and also more advanced schemes using these methods together with other available technology to perform and augment reservoir optimization. With this work, the author has attempted to make a genuine contribution to all the research areas this master's thesis has touched upon, ranging from computer science and AI to process and petroleum engineering. The methods and approaches developed through this research were compared to the performance of each other and also to other approaches and methods used on the same challenges. The comparison found some of the developed optimization schemes to be very successful, while others were found to be less appropriate for solving the problem at hand. Some of the less successful approaches still showed considerable promise for simpler problems, leading the author to conclude that the developed schemes are suited for solving optimization problems in the petroleum industry.
37
Dhillon, Dildeep Singh. « Sulfide and alkalinity production from activated sludge to treat acid mine drainage ». Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape17/PQDD_0004/MQ34116.pdf.
Texte intégral
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Haddad, Evette. « B cells as regulators of natural killer IFN-gamma production in mice ». Thesis, University of British Columbia, 2010. http://hdl.handle.net/2429/30413.
Texte intégralRésumé :
Natural killer (NK) cells are a potent source of interferon (IFN)-gamma which is required for the protection and clearance of microbial pathogens and tumours. Interleukin (IL)-12 is a cytokine released by dendritic cells (DC), macrophages (M-Phi), and B cells during early pathogenic infection in response to TLR signalling. It is a key inducer of IFN-gamma production and is thought to execute this primarily via the stimulation of NK cells. The focus of this thesis was to elucidate the cells involved in regulating mouse NK cell IFN-gamma release using stimulation with exogenous or endogenously produced IL-12. Our results show that IL-12 is able to stimulate IFN-gamma elaboration primarily from NK cells in cultures of unfractionated splenocytes, yet it is unable to stimulate highly purified NK cells unless exogenous IL-18 is also added. Macrophages, dendritic cells, or NKT cells do not act as partners to co-stimulate NK cell IFN-gamma production. Rather, our work uncovers a necessary and sufficient role for B cells in providing stimulatory help for NK cell IFN-gamma release during IL-12 stimulation. We show that B cells provide secreted IL-18 and contact dependent factors which remain undetermined. We next used the TLR9 ligand CpG-ODN (unmethylated cytokine-guanine dinucleotides) in order to test the ability of B cells to stimulate NK cell IFN-gamma production in the presence of endogenously produced IL-12. While NK cells were again the primary source of IFN-gamma in unfractionated splenocyte cultures, their activation was suppressed rather than enhanced by B cells. This suppressive activity was attributed to a small subset of splenic B cells that express CD5 and secrete IL-10 when directly activated with CpG. IL-10 suppressed the production of IFN-gamma from NK cells by reducing the levels of IL-12 available for NK cell stimulation, and by also acting on the NK cells directly and blunting their release of IFN-gamma. Overall, the research presented herein elucidates a novel role for B cells as both positive and negative regulators of resting NK cell IFN-gamma production in mice.
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Lohore, Serikpa Georges. « Tourisme et santé, mise en production des territoires par le tourisme médical ». Thesis, Perpignan, 2018. http://www.theses.fr/2018PERP0013/document.
Texte intégralRésumé :
L’association des concepts de tourisme et de santé, est marquée par une opposition qui découle de la nature des deux concepts. Le lien entre ces deux domaines de la vie des sociétés est protéiforme, et s’inscrit dans l’histoire, les pratiques sociales et l’actualité. Cette relation se décline sous la forme du thermalisme de l’Antiquité, à la création des premiers hôpitaux pour héberger les pèlerins du Moyen Âge, et l’organisation du premier voyage à forfait par Thomas Cook en 1841, dans une campagne contre l’alcool en Angleterre. Aujourd’hui la médecine du voyage et ses recommandations pour les séjours dans les pays tropicaux, de même que les récentes épidémies de portée mondiale, et leurs incidences sur l’économie touristique, ajoutent de nouveaux démembrements à la relation entre la santé et le voyage. Mais c’est par le biais du tourisme médical que cette étude tente d’approfondir le rapport entre les deux concepts. Forme de migration moderne, on découvre un secteur économique rapportant en 2013, près de 60 milliards de dollars, et un modèle économique que tentent de dupliquer de nombreuses destinations. Dans les préalables de ce phénomène, il y a pour ces destinations, une économie touristique efficace, et un secteur de la santé irrigué par un système d’assurance santé, sous son trait universel. Enfin le tourisme médical, dévoile sa face controversée, celle de l’Ethique re-questionnée dans la PMA, ou pour les suites médicales de la pratique, avec les problèmes post-opératoires. Mais c’est surtout sous la forme d’une nouvelle mise en valeur des territoires urbains, que pèse désormais le tourisme médical, en France et ailleurs aussiTourism and health are two concepts, at first sight in opposition. If tourism "is not based on any necessity," health, "engages the lives of individuals and societies." By scrutinizing the two concepts, it emerges a protean relationship that fits into history, social practices and current events. Despite the progress made in medicine, some tourist destinations, for specific epidemiological reasons are still destinations at risk. The current context of globalization, has influences in the field of health. The recent epidemics, H1N1 flu, Coronavirus etc., are today a threat to the planet. These experiences have shown the subjection of the tourism sector to the epidemiological state of the world. At this first connection between health and tourism, there is the one that makes health a consumer good, a design on which medical tourism is based. Medical tourism is a phenomenon brought to life by the media. The ambiguity of the term leads us to confess at the epistemological level of an inappropriate formula. However, it refers to a phenomenon that brings in nearly $ 60 billion in global revenue a year.These economic spinoffs support the expansion of the practice: Asia, Eastern Europe, North Africa, Latin America, and North America. The cost of care on these destinations, mostly emerging countries, Are much lower than in the countries of origin of patients. Legislation on certain medical acts is also important in medico-tourist motivations. PMA, transplants, abortion, participate motivations of medical tourism. However, the observations show a correlation between the emergence of this economic model, and the existence on the one hand, on the one hand, of a rich tourist activity, and on the other,of health insurance mechanism, covering the majority Population. In France we find the conditions for the development of a medical-tourist activity. However, the contribution of the Hexagon to this segment of the world economy is below its capacity, although it must be admitted that some cities are famous for hosting foreign patients. In city marketing, hospital facilities also define the importance of agglomerations. On this fact the cities of Paris, Marseille and Lyon, each has a medical-tourist activity. This study analyzes this segment in each of these cities, with their tourist and sanitary features.Thus, medical tourism is emerging as a new form of development of the territory, in France and elsewhere as well
40
Kahraman, Muhammet Mustafa. « Holistic Mine Management By Identification Of Real-Time And Historical Production Bottlenecks ». Diss., The University of Arizona, 2015. http://hdl.handle.net/10150/566211.
Texte intégralRésumé :
Mining has a long history of production and operation management. Economies of scales have changed drastically and technology has transformed the mining industry significantly. One of the most important technological improvements is increased equipment, human, and plant tracking capabilities. This provided a continuous data stream to the decision makers, considering dynamic operational conditions. However, managerial approaches did not change in parallel. Even though many process improvement tools using equipment/human/plant tracking capabilities were developed (Fleet Management Systems, Plant Monitoring Systems, Workforce Management Systems etc.), to date there is no holistic approach or system to manage the entire value chain in mining. Mining operations are designed and managed around the already known system designated bottlenecks. However, contrary to common belief in mining, bottlenecks are not static. They can shift from one process or location to another. It is important for management to be aware of the new bottlenecks, since their decisions will be effected. Therefore, identification of true bottlenecks in real-time will help tactical level decisions (use of buffers, resource transfer), and identification of historical bottlenecks will help strategic-level decisions (investments, increasing capacity etc.). This thesis aims to address the managerial focus on the true bottlenecks. This is done by first identifying and ranking true bottlenecks in the system. The study proposes a methodology for creating Bottleneck Identification Model (BIM) that can identify true bottlenecks in a value chain in real-time or historically, depending on the available data. This approach consists of three phases to detect and rank the bottlenecks. In the first phase, the system is defined and variables are identified. In the second phase, the capacity, rates, and buffers are computed. In the third phase, considering particularities of the mine exceptions are added by taking mine characteristics into account, and bottlenecks are identified and ranked.
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Farmer, Brandon. « Effects of Microgravity on Mucin Production in the Urinary Bladder in Mice ». Digital Commons @ East Tennessee State University, 2012. https://dc.etsu.edu/honors/137.
Texte intégralRésumé :
The effects of the microgravity of spaceflight are largely unexplored with regard to biological tissues. One particular area of interest is the possible effects microgravity could have on the production of mucins. To determine the possible effects of microgravity on mucin production in the urinary bladder, we examined the transitional epithelium of the urinary bladder from female mice that were flown on the space shuttle Endeavour for 12 days in August, 2007. The flight tissue was compared to tissues from two control groups of animals, ground control and baseline. This study utilized three sets of female mice, with each set consisting of 12 animals. The three sets were designated as Flight, Ground Control, and Baseline. The flight animals were flown in the Commercial Biomedical Testing Module-2 (CBMT-2) which was housed in the shuttle’s mid-deck locker area. Ground control animals were also housed in CBTM-2 units which were kept in environmentally controlled rooms at the Space Life Sciences Lab at Kennedy Space Center. Baseline animals were also housed at the Space Life Sciences Lab but were housed in standard rodent cages with ambient temperature and humidity, with a 12/12 light dark cycle. Bladder tissue was paraffin embedded, sectioned, mounted, and histologically stained using an Alcian Blue Periodic Acid Schiff staining procedure. The bladder tissue from the three treatment groups is being qualitatively analyzed for mucin thickness and types of mucins produced. To date the study indicates that the mucin layer of the Flight tissue is thinner than that of the Baseline or Ground Control tissue, but only significantly thinner than the Baseline tissue.
42
Ng, Shuk-ming Sandy. « A study on the production of transgenic mice by pronuclear microinjection and by sperm incorporation of immunoglobulin genes / ». [Hong Kong : University of Hong Kong], 1992. http://sunzi.lib.hku.hk/hkuto/record.jsp?B13215905.
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Leveroos, Maura K. « Economic Viability of Woody Bioenergy Cropping for Surface Mine Reclamation ». Thesis, Virginia Tech, 2013. http://hdl.handle.net/10919/50950.
Texte intégralRésumé :
Planting woody biomass for energy production can be used as a mine reclamation procedure to satisfy the Surface Mining Control and Reclamation Act of 1977 (SMCRA) and provide renewable energy for the United States. This study examines the economic viability of bioenergy production on previously mined lands using multiple hardwood species and treatments. Five species were planted at two densities; one-half of the trees were fertilized in year two. Height and diameter of the trees were measured annually for five years; the first three years by cooperating researchers at Virginia Tech, the last two years specifically for this report. Current and predicted mass of the species, effects of planting density and fertilizer application, and the land expectation value (LEV) of each treatment were summarized. A sensitivity analysis was conducted to determine how changes in production costs, stumpage price, rotation length, and interest rate affect the economic feasibility of bioenergy production. Renewable energy and mine reclamation policies were investigated and it was determined that woody bioenergy can be planted as a mine reclamation procedure and may receive financial incentives. Production cost appears to have the largest impact on LEV and is often the difference between positive and negative returns for the landowner. The extra cost of fertilization and high density planting do not increase LEV; the unfertilized, low density treatments have the best LEV in all examined scenarios. In general, bioenergy was found to be economically viable as a mine reclamation procedure only in limited circumstances. In low cost, high price scenarios, bioenergy crops could have the potential to reforest both active and abandoned mine lands throughout southern Appalachia.Master of Science
44
Sanchez, Ghislaine. « Cacher dans le champ, cacher hors-champ : deux escamotages de la mise en scène filmique ». Paris 10, 1985. http://www.theses.fr/1985PA100200.
Texte intégral
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Ginsburger, Emmanuel. « Définition et mise au point d'une méthodologie pour l'extrapolation de procédés de copolymérisation en émulsion ». Vandoeuvre-les-Nancy, INPL, 2001. http://www.theses.fr/2001INPL045N.
Texte intégralRésumé :
Cette thèse a pour objet la définition et la mise au point d'une méthodologie pour l'extrapolation industrielle de la synthèse de polymères en émulsion. Ces matériaux sont synthétisés selon un procédé semi-continu, en deux étapes d'addition séparées par un temps de cuisson intermédiaire dans le but d'obtenir des particules ayant une structure coeur-écorce. Selon les voies et les conditions de synthèse envisagées, les produits obtenus peuvent présenter des propriétés différentes. Après une approche bibliographique nécessaire à la compréhension des phénomènes physicochimiques mis en jeu lors d'une polymérisation en émulsion et à l'utilisation de ces produits dans la formulation de peintures, la première partie de ce manuscrit est consacrée à l'étude cinétique de deux formulations industrielles et à l'analyse de l'influence de la modification de paramètres procédé sur leurs propriétés applicatives. Les paramètres procédés testés sont principalement : la température réactionnelle et le temps d'ajout. La seconde partie est consacrée au développement d'une nouvelle recette industrielle. Dans un premier temps, une formulation chimique et un type de procédé adapté ont été choisis. Ensuite, le procédé concerné a été modélisé. La modélisation réalisée concerne la prédiction des conversions, des masses molaires moyennes, des tailles et des concentrations des particules en fonction des conditions opératoires (concentration en émulsifiant, en amorceur, en monomères, température de réaction et débits d'alimentation). L'identification des paramètres du modèle est alors effectuée par rapport à des mesures expérimentales réalisées en réacteur discontinu pour décrire parfaitement le schéma complet d'une polymérisation en émulsion. Le modèle ainsi défini est alors utilisé, dans un premier temps comme simulateur puis est ensuite intégré dans une procédure d'optimisation multicritère afin de pouvoir maîtriser finement les propriétés applicatives du latex. N s' agit d'obtenir le meilleur compromis possible parmi l'ensemble des objectifs que l'on peut se fixer en termes de productivité et de propriétés du polymère. Enfin, les trajectoires optimales, définies ultérieurement, seront utilisées lors de la commande prédictive des procédés concernés pour assurer une reproductibilité et une sécurité maximales pendant leur mise en oeuvreThe aim of this work is the definition and the improvement of a method for the industrial scale up of emulsion polymerization. These materials are prepared by a semi-batch process in different stages in order to obtain a Core/Shell morphology. According to the process parameters used, the obtained products can reach different end-use properties. After a detailed review of the literature available on emulsion polymerization mechanisms and polymer behavior in paint formulation, the first part of the work deals with the kinetic study of two semi-batch industrial polymerizations and the analysis of the influence of the main process key parameters (reaction temperature and feedings rate) on the end use properties of the latex. The second part is dedicated to the development of an industrial recipe. First, a chemical formulation and a type of process are chosen. Then, the concemed process is modeled. The model predicts satisfactorily conversion, average molecular weights, particles sizes and concentrations as a function of operating conditions (emulsifier, initiator and monomer concentrations). Key parameters of the model are identified on the basis of batch experimental data in order to describe the overall kinetic sketch of emulsion polymerization. The model is then used as a simulator and is integrated in a multicriteria optimization procedure in order to master the quality of the product. The decision aid problem consists in obtaining the best tradeoff as possible from ali fixed objectives. The multicriteria optimization technique is elaborated from a haploid genetic algorithm. In fact, the final results will be a multivariable trajectory, optimized in a multicriteria sense, which will be later used for the predictive control of the process
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Vasilakou, Antonia. « Le mime tragique dans les mises en scène de Jean-Louis Barrault : quatre exemples : la Faim, Antoine et Cléopâtre, Baptiste et Les Suites d’une course ». Thesis, Paris 10, 2014. http://www.theses.fr/2014PA100119.
Texte intégralRésumé :
Le sujet traite de la notion du mime tragique de J.-L. Barrault dans quatre de ses mises en scènes relatives à l'art du geste et du mime.La première partie de la thèse trace les influences qui ont forgées artistiquement Barrault, dont J. Copeau, le Cartel et plus particulièrement Ch. Dullin. Une grande partie est consacrée à Étienne Decroux sur les niveaux théorique et pratique du mime corporel de Barrault. Barrault fut aussi sous le charme « magnétique » d'A. Artaud ce qui sera également évoqué à divers moments dans cette recherche. La partie est complétée par une section dédiée à l’empreinte que Barrault, par son enseignement et son travail, a laissée sur les mimes connus tels M. Marceau et J. Lecoq. La deuxième partie, définira la notion du mime tragique. Dans l’article « Le mime tragique », Barrault étend la notion du mime à l’action dramatique tout en la liant aux pouvoirs du corps humain, afin qu’elle devienne à la fois, la médiatrice entre la vie intérieure et la vie extérieure et leur expression sur scène. Le mime tragique parle d’un théâtre en interaction avec ses ressources corporelles. Il laisse entrevoir un point de vue du mime élargi, car Barrault s’éloigne de l’aspect “purement mime” pour l’étendre à un langage corporel plus vaste, composé de la technique du mime corporel Decroux, de la pensée d’Artaud, de Dullin, de Craig et même de Stanislavski. Dans la troisième et dernière partie, grâce au matériel du Fonds Renaud-Barrault, les mises en scène de Jean-Louis Barrault sont examinées du point de vue de la présence en elles du corps et du mime Il s’agit d’un chapitre qui analyse les composants du mime tragique (tels que l'action objective, l'action subjective, vie intérieure, le Double et autres) dans les pièces La Faim, Antoine et Cléopâtre, Baptiste, Les Suites d’une courseThe subject deals with the concept of the tragic mime Jean-Louis Barrault in four of his theatrical performances related to the art of gesture and mime. The first part of the thesis traces the influences that have forged artistically Barrault, including J. Copeau, the Cartel and especially Ch. Dullin. A large part is devoted to Etienne Decroux’s influence on a theoretical and practical level. Barrault was also under the "magnetic" charm of A. Artaud which will also be discussed various times in this research. The section is completed by the description of Barrault’s teaching and work and its influence to well-known mimes, such as M. Marceau and J. Lecoq. The second part defines the notion of the tragic mime. In to the article “Le mime tragique” Barrault extends the notion of mime as a dramatic action. Mime becomes the mediator between the inner life, the outer life and their expression on stage. The tragic mime talks about a theater in an interaction with the actors corporeal resources. It suggests a broader perspective of mime, since Barrault deviates from the "pure mime" so as to extend it to a wider body language, consisted of Decroux’s mime technique and Artaud’s, Dullin’s, Craig’s and even Stanislavski’s theories and practices.In the third and last part, thanks to the material of the Fonds Renaud-Barrault, the directing of Jean-Louis Barrault is analyzed from the view of the corporeal presence and mime elements into his theatrical performances. Tragic mime components (such as objective action, subjective action, inner life, dublicity, etc) in the staging, will be analyzed extensively
47
Cakmak, Baris Bezmi. « Investigation Of Ground Vibrations Induced By Production Blasting At Usak Kisladag Gold Mine ». Master's thesis, METU, 2007. http://etd.lib.metu.edu.tr/upload/3/12608744/index.pdf.
Texte intégralRésumé :
Ground vibrations from blasting are acoustic waves that propagate through the earth. They are also termed seismic waves because their propagation characteristics are similar to the ground motions produced by earthquakes. Amplitude of ground vibration induced by blasting may vary significantly at or around an open pit mine depending on parameters such as the maximum amount of explosive detonating at a time interval and the physical distance between the shot and the location of concern, whereas the frequency of vibration mainly vary depending on the geology and blast delay intervals. Therefore evaluation and assessment of ground vibration condition at or around an open pit mine is necessary.
The objective of the proposed research study is to monitor and record the ground vibration and to investigate and assess the vibration conditions at neighbouring districts that are induced by production blasting operations at Usak KiSladag Gold Mine. In this research study, several parameters such as the ground vibration velocity, the amount of charge per delay, the physical distance to the location of monitoring device or residential structures are recorded, analyzed and evaluated together with the frequencies of the seismic waves. The determined ground vibration velocities are compared with the allowable limits given in Turkish Regulation and US Federal Regulation. Thus, the compliance of the ground vibrations with the above mentioned regulations are discussed and assessed. Furthermore, the parameters which affect the ground vibration are discussed and determined.
In this study, the monitored and the recorded ground vibrations are evaluated from structural damage potential and human disturbance points of views. It is determined that the ground vibration levels recorded during this study and analyzed from the past records comply with Turkish and US Federal regulations. It is concluded that no damage has been occurred in structures at surrounding settlements and the occupants were not disturbed by the direct effect of vibrations in the past and at present. The analysis proved that the blasting operations to be conducted in the future will not create any damage and disturbance provided that the charge detonated per delay is kept less than 155 kg’
s.
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Rankin, Joanna Marie. « Cloning and characterisation of the gene controlling GP70 autoantigen production in BXSB mice ». Thesis, Imperial College London, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.429882.
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Poirion, Pierre-Louis. « Programmation linéaire mixte robuste ; Application au dimensionnement d'un système hybride de production d'électricité ». Thesis, Paris, CNAM, 2013. http://www.theses.fr/2015CNAM0948/document.
Texte intégralRésumé :
Dans cette thèse, nous nous intéressons à l’optimisation robuste. Plus précisément,nous nous intéresserons aux problèmes linéaires mixtes bi-niveaux, c’est à dire aux problèmes dans lesquels le processus de décision est divisé en deux parties : dans un premier temps, les valeurs optimales des variables dites "de décisions" seront calculées ; puis, une fois que l’incertitude sur les données est levée, nous calculerons les valeurs des variables dites "de recours". Dans cette thèse, nousnous limiterons au cas où les variables de deuxième étape, dites "de recours", sontcontinues.Dans la première partie de cette thèse, nous nous concentrerons sur l’étudethéorique de tels problèmes. Nous commencerons par résoudre un problème linéairesimplifié dans lequel l’incertitude porte seulement sur le membre droit descontraintes, et est modélisée par un polytope bien particulier. Nous supposerons enoutre que le problème vérifie une propriété dite "de recours complet", qui assureque, quelles que soient les valeurs prises par les variables de dcisions, si ces dernières sont admissibles, alors le problème admet toujours une solution réalisable, et ce, quelles que soient les valeurs prises par les paramètres incertains. Nous verrons alors une méthode permettant, à partir d’un programme robuste quelconque, de se ramener à un programme robuste équivalent dont le problème déterministe associévérifie la propriété de recours complet. Avant de traiter le cas général, nous nouslimiterons d’abord au cas o les variables de décisions sont entières. Nous testeronsalors notre approche sur un problème de production. Ensuite, après avoir remarquéque l’approche développée dans les chapitres précédents ne se généralisait pasnaturellement aux polytopes qui n’ont pas des points extrmes 0-1, nous montreronscomment, en utilisant des propriétés de convexité du problème, résoudre le problème robuste dans le cas général. Nous en déduirons alors des résultats de complexité sur le problème de deuxième étape, et sur le problème robuste. Dans la suite de cette partie nous tenterons d’utiliser au mieux les informations probabilistes que l’on a sur les données aléatoires pour estimer la pertinence de notre ensemble d’incertitude.Dans la deuxième partie de cette thèse, nous étudierons un problème de conceptionde parc hybride de production d’électricité. Plus précisément, nous chercheronsà optimiser un parc de production électrique constitué d’éoliennes, de panneauxsolaires, de batteries et d’un générateur à diesel, destiné à répondre à unedemande locale d’énergie électrique. Il s’agit de déterminer le nombre d’éoliennes,de panneaux solaires et de batteries à installer afin de répondre à la demande pourun cot minimum. Cependant, les données du problème sont très aléatoires. En effet,l’énergie produite par une éolienne dépend de la force et de la direction du vent ; celle produite par un panneau solaire, de l’ensoleillement et la demande en électricité peut tre liée à la température ou à d’autres paramètres extérieurs. Pour résoudre ce problème, nous commencerons par modéliser le problème déterministeen un programme linéaire mixte. Puis nous appliquerons directement l’approche de la première partie pour résoudre le problème robuste associé. Nous montrerons ensuite que le problème de deuxième étape associé, peut se résoudre en temps polynomial en utilisant un algorithme de programmation dynamique. Enfin, nous donnerons quelques généralisations et améliorations pour notre problèmeRobust optimization is a recent approach to study problems with uncertain datathat does not rely on a prerequisite precise probability model but on mild assumptionson the uncertainties involved in the problem.We studied a linear two-stage robustproblem with mixed-integer first-stage variables and continuous second stagevariables. We considered column wise uncertainty and focused on the case whenthe problem doesn’t satisfy a "full recourse property" which cannot be always satisfied for real problems. We also studied the complexity of the robust problemwhich is NP-hard and proved that it is actually polynomial solvable when a parameterof the problem is fixed.We then applied this approach to study a stand-alonehybrid system composed of wind turbines, solar photovoltaic panels and batteries.The aim was to determine the optimal number of photovoltaic panels, wind turbinesand batteries in order to serve a given demand while minimizing the total cost of investment and use. We also studied some properties of the second stage problem, in particular that the second stage problem can be solvable in polynomial time using dynamic programming
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Etchegoyen, Grégory. « Développement d'une membrane céramique conductrice mixte pour la production de gaz de synthèse ». Limoges, 2005. http://aurore.unilim.fr/theses/nxfile/default/d4efe5f3-0cbb-4d2b-a68b-376d3b959e27/blobholder:0/2005LIMO0026.pdf.
Texte intégralRésumé :
La conversion du gaz naturel en gaz de synthèse (H2+CO) constitue un enjeu majeur pour la production d'hydrogène ou de carburants propres par GTL, fournissant ainsi une alternative aux produits pétroliers et réduisant l'émission de gaz à effet de serre. La production de ce gaz à l'aide d'une membrane céramique conductrice mixte (ionique et électronique) semble particulièrement prometteuse. Cette thèse a consisté à développer ce type de membrane. L'oxyde conducteur mixte a été synthétisé, caractérisé puis mis en forme par coulage en bande et co-frittage pour aboutir à des membranes multicouches d'architecture et microstructure contrôlées. Les performances des membranes ont été estimées en mesurant les flux de perméation de l'oxygène à l'aide d'un montage spécifique. L'optimisation de l'architecture/microstructure de la membrane a permis d'augmenter le flux d'un facteur 30. Enfin, la formulation du conducteur mixte a fait l'objet d'une étude particulière, dans l'objectif d'améliorer la stabilité dimensionnelle de la membrane. Natural gas conversion into syngas (H2+CO) is very attractive for hydrogen and clean fuel production via GTL technology by providing an alternative to oil products and reducing greenhouse gas emission. Syngas production, using a mixed ionic-electronic conducting ceramic membrane, is thought to be particularly promising. The purpose of this PhD thesis was to develop this type of membrane. Mixed-conducting oxide was synthesized, characterized and then, shaped via tape casting and co-sintered in order to obtain multilayer membranes with controlled architectures and microstructures. Oxygen permeation fluxes were measured with a specific device to evaluate membrane performances. As a result, the optimisation of architecture and microstructure made it possible to increase oxygen permeation flux by a factor 30. Additional researches were focused on the oxide composition in order to achieve higher dimensional stability